[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"kidney-neoplasms--surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:kidney-neoplasms--surgery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100590928","the-study-on-the-effectiveness-of-68gaga-hbed-cc-diasp-petct-in-calculating-gfr-and-predicting-residual-renal-function-after-partial-nephrectomy-100590928",false,"NCT06973798","The Study on the Effectiveness of [68Ga]Ga-HBED-CC-DiAsp PET\u002FCT in Calculating GFR and Predicting Residual Renal Function After Partial Nephrectomy","The Study on the Effectiveness of [68Ga]Ga-HBED-CC-DiAsp PET\u002FCT in Calculating Glomerular Filtration Rate and Predicting Residual Renal Function After Partial Nephrectomy","Inclusion Criteria:\n\n* Age \\> 18 years;\n* Written informed consent obtained.\n\nExclusion Criteria:\n\n* Patients with claustrophobia or fear of radiation;\n* Women who are planning to conceive, pregnant, or breastfeeding;\n* Patients unable to lie flat for 30 minutes;\n* Patients or family members who cannot understand the conditions and objectives of the study, or who refuse to participate.",true,"ALL","18 Years","88 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","In subjects with different levels of renal function and no history of renal tumors, GFR is measured using \\[68Ga\\]Ga-HBED-CC-DiAsp PET\u002FCT, the Gates method, and the 99mTc-DTPA dual plasma method. The consistency between the three methods is analyzed using intra-class correlation coefficient (ICC), concordance correlation coefficient (CCC), and Bland-Altman analysis.\n\nIn patients scheduled for partial nephrectomy due to renal tumors, GFR is measured using the three methods within 2 weeks before surgery and 4±1 weeks post-surgery. The percentage of postoperative residual renal function (postoperative GFR\u002Fpreoperative GFR × 100%, hereafter referred to as RRF%) is calculated for each method. By comparing and overlaying preoperative and postoperative PET\u002FCT images, the resected renal area can be delineated on the preoperative PET\u002FCT image. Based on the preoperative PET\u002FCT and the delineated surgical area, a predictive value for postoperative GFR is calculated to obtain the predicted RRF%. A consistency analysis is then performed between the predicted RRF% and the actual RRF% measured by the three methods, using ICC, CCC, and Bland-Altman analysis to evaluate the efficacy of \\[68Ga\\]Ga-HBED-CC-DiAsp PET\u002FCT in predicting residual renal function after partial nephrectomy.",[28,29,30],"Kidney Neoplasms \u002F Surgery","Glomerular Filtration Rate","Positron-Emission Tomography(PET)",[32,33,34,35],"[68Ga]Ga-HBED-CC-DiAsp","PET\u002FCT","glomerular filtration rate","partial nephrectomy","NOT_YET_RECRUITING","2025-05-07",{"date":39,"type":40},"2025-05-15","ACTUAL",{"date":42,"type":22},"2025-07-01",{"date":44,"type":22},"2025-11-10",{"name":46,"class":47},"Luo Yaping","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":48},"100571189","a-study-of-3d-visualization-techniques-to-improve-the-quality-and-safety-of-robot-assisted-nephron-sparing-surgery-for-complex-renal-tumors-100571189","NCT06717009","A Study of 3D Visualization Techniques to Improve the Quality and Safety of Robot-assisted Nephron Sparing Surgery for Complex Renal Tumors.","A Prospective, Multicenter, Randomized Controlled Study of Three-dimensional Visualization Techniques to Improve the Quality and Safety of Robot-assisted Nephron Sparing Surgery for Complex Renal Tumors","Inclusion Criteria:\n\n1. The imaging diagnosis is single renal cell carcinoma, clinical stage is T1N0M0-T2N0M0, and the contralateral kidney function is good.\n2. Physical status and organ function allow robotic-assisted partial nephrectomy.\n3. Be able to adhere to the protocol during the study.\n4. The age ranges from 18 to 75 years, and there is no chronic kidney disease.\n5. KPS \\> 80; ECOG score: 0-1; There are no other serious concomitant diseases and the organ function is good.\n6. There are no medical contraindications seriously affecting anesthesia and surgery.\n7. The patient has no history of other malignant tumors in the past 5 years.\n8. There is no surgical history of epigastrium and the affected kidney.\n9. Estimated survival is more than 6 months, and there are no other severe diseases that reduce survival to less than 5 years.\n\nExclusion Criteria:\n\n1. Women who are pregnant or lactating, or who are of reproductive age and are not using effective contraception.\n2. Comorbid serious medical diseases or conditions, for example, clinically severe or active heart disease, severe uncontrolled medical illnesses and infections, severe uncontrolled digestive disorder, severe electrolyte disturbance, active disseminated intravascular coagulation, major organ failure such as decompensated cardiac, pulmonary, hepatic, or renal failure, symptomatic peripheral neuropathy. Can not tolerate robot-assisted laparoscopic partial nephrectomy\n3. Organ transplant recipients requiring immunosuppressive therapy.\n4. There is history of other malignancies within 5 years of trial initiation, excluding cured basal cell carcinoma of the skin and carcinoma in situ of the cervix.\n5. Patients who have received biological therapy or other anticancer traditional Chinese medicine within 4 weeks.\n6. Patients with multiple or bilateral renal tumors or solitary renal tumors.\n7. Patient without complete clinical information.","75 Years",{"count":58,"type":22},350,[25],"The goal of this clinical trial is to learn the evidence-based medical value of 3D visualization techniques to improve tumor control, preservation of renal function, and perioperative safety in robot-assisted nephron sparing surgery for complex renal tumors. The main question it aims to answer is:\n\nIs 3D visualization techniques more effective in improving robot-assisted nephron sparing surgery for complex renal tumors in terms of tumor control, renal function preservation, and perioperative safety.\n\nThe researchers will randomize participants into a 3D trial group and a conventional group for comparison.\n\nParticipants will:\n\nComplete Blood routine, liver and kidney function tests on the first and third day after operation.\n\nHave Renography at 3 and 12 months after the operation. Cooperate with follow-up visits.",[28,62,63,64],"Robotic Surgical Procedures","Imaging, Three-Dimensional \u002F Methods","Nephrectomy \u002F Methods",[66,67,68,69,70,71],"Three-dimensional visualization technique;","Three-dimensional reconstruction","Robotic surgery","Kidney neoplasms","Laparoscopy","Nephron sparing surgery","2024-11-29",{"date":74,"type":40},"2024-12-04",{"date":76,"type":22},"2025-01",{"date":78,"type":22},"2027-10",{"name":80,"class":47},"Tianjin Medical University Cancer Institute and Hospital"]