[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"kidney-rejection-transplant\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:kidney-rejection-transplant":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100599955","molecular-transcriptomics-in-diagnosing-pediatric-kidney-transplant-rejection-the-panda-kids-atlas-study-100599955",false,"NCT07091214","Molecular Transcriptomics in Diagnosing Pediatric Kidney Transplant Rejection: the PANDA-Kids-ATLAS Study","Precision Allograft Rejection Using Novel Diagnostic Approaches in Kidney Transplantation - Allograft Transcriptomics Landscape Analysis Using Sequencing (the PANDA-Kids-ATLAS Study)","Inclusion Criteria:\n\n* Age ≤ 21 years\n* Single kidney transplant recipients (deceased or living donor)\n* Written informed consent from patients\u002Fguardians\n\nExclusion Criteria:\n\n* Multi-organ transplantation history\n* Biopsies with insufficient tissue",true,"ALL","0 Years","21 Years",{"count":21,"type":22},600,"ESTIMATED","OBSERVATIONAL","Children with kidney failure have markedly increased mortality and face repeated transplantation over their lifetime due to limited allograft half-life (12-15 years). Current biopsy-based diagnoses of rejection (using Banff 2022 criteria) suffer from variability and limited sensitivity. PANDA-Kids-ATLAS will analyze up to 600 pediatric FFPE kidney biopsies across multiple centres using the Banff Human Organ Transplant (B-HOT) NanoString panel to develop and validate molecular classifiers of AMR, TCMR and related phenotypes. A secure REDCap database will integrate molecular, pathological and clinical data, aiming to improve early detection, personalize therapy, and enhance long-term graft survival and patient quality of life.",[26],"Kidney Rejection Transplant",[28,29,30,31,32],"transcriptomics","pediatric kidney transplantation","allograft rejection","precision diagnosis","molecular classifiers","NOT_YET_RECRUITING","2025-07-28",{"date":36,"type":37},"2025-07-29","ACTUAL",{"date":39,"type":22},"2025-09-01",{"date":41,"type":22},"2028-12-31",{"name":43,"class":44},"Paris Translational Research Center for Organ Transplantation","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},"100542381","molecular-landscape-of-microvascular-inflammation-in-kidney-allografts-100542381","NCT06342128","Molecular Landscape of Microvascular Inflammation in Kidney Allografts","Comprehensive Multiscale Characterization of the Molecular Landscape of Microvascular Inflammation in Kidney Allografts","Inclusion Criteria:\n\n\\- Adult kidney transplant recipients, with at least one kidney transplant biopsy performed and assessed according to the international Banff 2022 classification, with or without lesions of microvascular inflammation\n\nExclusion Criteria:\n\n* Inadequate biopsy according to the Banff classification\n* Missing data for Banff lesion scores, donor-specific antibody status, C4d staining\n* Biopsies showing histological signs of ischemia-reperfusion\n* Combined transplantation and kidney transplantation after a non-kidney solid organ transplantation","18 Years","100 Years",{"count":21,"type":22},"Microvascular inflammation in kidney allografts has been widely reappraised in the recent update of Banff classification. There is a critical need to better understand the pathophysiological mechanisms associated with the various phenotypes of microvascular inflammation that are observed in kidney transplants, particularly in order to develop targeted therapeutic approaches.",[26],"RECRUITING","2025-05-27",{"date":61,"type":37},"2025-05-31",{"date":63,"type":37},"2022-01-01",{"date":65,"type":22},"2025-12",{"name":43,"class":44},3]