[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"kidney-stones-urolithiasis-hypocitraturia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:kidney-stones-urolithiasis-hypocitraturia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100634200","relief-efficacy-of-lidocaine-versus-morphine-for-acute-renal-colic-in-the-emergency-department-100634200",false,"NCT07536594","Relief Efficacy of Lidocaine Versus Morphine for Acute Renal Colic in the Emergency Department","RELIEF-RC: Relief Efficacy of LIdocaine Versus morphinE For Acute Renal Colic in the Emergency Department","RELIEF-RC","Inclusion Criteria:\n\nIn order to be eligible for inclusion in the study, an individual must meet all of the following criteria:\n\n* Age ≥ 18 years at time of visit\n* Able and willing to consent for participation in study\n* Documentation of suspected renal colic as primary complaint as evidenced by reported flank pain, back pain, abdominal pain, or groin pain, or as determined by the treating clinician\n* Requires additional treatment due to inadequate analgesia or clinical suspicion of unsafe discharge secondary to pain after initial treatment with parenteral ketorolac\n\nExclusion Criteria:\n\nAny individual who meets any of the following criteria will be excluded from participation in this study:\n\n* Age \\\u003C 18 years\n* Use of analgesia for renal colic within 6 hours prior to clinician evaluation\n* Inability or unwillingness to consent for participation in study\n* Experienced a severe adverse event that required clinician intervention after initial treatment with parenteral ketorolac\n* Documented history of allergic or anaphylactic reaction to NSAIDs, lidocaine, or morphine\n* Documented history of cardiac arrhythmias\n* Documented history of chronic use of opioid medications for unrelated diagnoses\n* Currently pregnant\n* Documented history of end-stage renal or hepatic dysfunction\n* Clinical contraindications to NSAIDs, lidocaine, or morphine per clinician discretion","ALL","18 Years",{"count":20,"type":21},250,"ESTIMATED","INTERVENTIONAL",[24],"NA","The opioid epidemic continues to be a major public health crisis in the United States. According to the Center for Disease Control, approximately 8 million Americans reported misusing prescription opioids in 2023, with over 5 million Americans reporting that they suffer from opioid use disorder. The United States government estimates that 105,000 people died from drug overdose in 2023, and approximately 80,000 of those deaths can be attributed to opioids (\\~76%). In acknowledgement of the opioid crisis, we wish to contribute to ongoing efforts to reduce unnecessary and excessive opioid prescription.\n\nIn 2012, researchers in Iran published a randomized controlled trial comparing intravenous (IV) lidocaine to IV morphine for acute renal colic, reporting that 90% patients responded \"successfully\" in the lidocaine group versus 70% in the morphine group. They also concluded that there was a statistically significant difference between pain scores between the two groups at all time points, favoring the lidocaine group. However, the study was conducted at a single emergency department in Tabriz, Iran, with a relatively homogenous patient population, and the researchers did not explicitly define their primary outcome variable for what constituted a \"successful\" response in the treatment groups. The investigators of this study aim to build upon this preliminary evidence by recruiting a more diverse population to improve generalizability and by predefining pain-reduction thresholds to allow for more meaningful comparison between the interventions.",[27,28,29],"Renal Colic","Kidney Stones, Urolithiasis, Hypocitraturia","Opioid Use During Medical Care",[31,32,33,34],"renal colic","kidney stones","lidocaine","opioid use","NOT_YET_RECRUITING","2026-04-15",{"date":38,"type":39},"2026-04-17","ACTUAL",{"date":41,"type":21},"2026-06",{"date":43,"type":21},"2028-06",{"name":45,"class":46},"Loma Linda University","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100624318","phase-1-sodium-bicarbonate-as-an-alternative-to-potassium-citrate-for-kidney-stones-100624318","NCT07408076","Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones","Inclusion Criteria:\n\n* Adult \\>18 years of age\n* History of nephrolithiasis\n* One 24h urine collections within one year of enrollment with hypocitraturia.\n* Patients currently utilizing or considering use of Kcit for stone prevention\n\nExclusion Criteria:\n\n* Individuals with known metabolic disorders\n* Individuals with other known causes of nephrolithiasis\n* Anyone who, in the opinion of the PI, is unfit or unsuitable to participate in the study",{"count":54,"type":21},30,[56,57],"PHASE1","PHASE2","Kidney stones affect 1 in every 11 people in the US each year. In patients with kidney stones who are prescribed medications for stone management, only 30.2% are adherent to a medication regime and even fewer, only 13.4 % are adherent with citrate medications.\n\nPrescription potassium citrate can be expensive for many patients, leading to non-compliance. Sodium bicarbonate is a potential medication alternative that is cheaper and can potentially alkalinize the urine and\u002For decrease the risk of future kidney stones. However, efficacy of alternatives to potassium potassium citrate are not well studied.\n\nThis study seeks to evaluate sodium bicarbonate and assess its ability to alkalinize urine in a cohort of patients with kidney stones and compare this to prescription potassium citrate.",[28,60],"Nephrolithiasis",[62,63,64,65,66,67,68],"kidney stone","stone","calcium oxalate","calcium phosphate","potassium citrate","sodium bicarbonate","nephrolithiasis","2026-02-05",{"date":71,"type":39},"2026-02-12",{"date":73,"type":21},"2026-02-01",{"date":75,"type":21},"2028-02-01",{"name":77,"class":46},"University of California, Los Angeles",6,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100598354","the-use-of-ar--vr-in-patients-presenting-to-the-ed-with-renal-colic-100598354","NCT07070401","The Use of AR \u002F VR in Patients Presenting to the ED With Renal Colic","Inclusion Criteria:\n\n* Patient self-reported history of nephrolithiasis\n* Subjective history suggesting that current presentation is similar to past presentations of nephrolithiasis (character, quality, location, intensity of pain; previous surgical intervention or lithotripsy)\n* Patients with self-reported moderate to severe pain on the visual pain scale determined as greater than 5\u002F10\n* Normal vital signs (afebrile)\n* Agreeable to informed consent as dictated by IRB and local practice\n* No contraindications to standard therapy (ie fluids, NSAIDs, opioids, etc.)\n* Compliance with the virtual reality treatment\n* Keeps the headset on for the duration of the experience\n* Understands the instructions\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Pregnant\n* Individuals with chronic pain conditions such as fibromyalgia (chronic pain may confound results, as patients may have higher than baseline pain levels affecting their response to medications)\n* Individuals with severe anxiety or claustrophobia\n* Individuals with severe motion sickness or previous episodes of motion sickness due to VR (those who may not react well to the VR experience)\n* Individuals with GFR\\\u003C60 or previous documented diagnosis of CKD as they may not be suitable candidate for traditional analgesia\n* Individuals with previous opioid dependence\n* Requirement of immediate surgery (obstructing calculi with concomitant urinary tract infection)\n* Patients with diagnoses meeting admission criteria (sepsis, MI)\n* Audio\u002Fvisual impairment (unable to appreciate stimuli provided by the headset)\n* Patients administered opiates as the first line pain control medication will not be included in final data collection, as opioid administration may result in difficulty consenting and understanding the study protocol \u002F design",{"count":86,"type":21},92,[24],"Utilization of VR \u002F AR Calming as an adjunct to pharmacologic pain management for Renal Colic in Emergency Department Patients",[27,28],[27,60,91,92,93,94,95,96,97],"Urolithiasis","Emergency Department","Pain Management","Virtual Reality","Augmented Reality","Audiovisual Stimulation","Patient Anxiety","RECRUITING","2025-07-08",{"date":101,"type":39},"2025-07-17",{"date":103,"type":39},"2025-04-01",{"date":105,"type":21},"2026-03-31",{"name":107,"class":46},"Community Medical Center, Toms River, NJ",1]