[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"kidney-stones\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:kidney-stones":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,27,0,25,[9,52,79,105,138,161,190,212,233,258,286,309,329,356,383,404,426,448,475,500,523,549,568,592,619],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100053219","modified-mini-pcnl-versus-standard-pcnl-for-complex-kidney-stones-100053219",false,"NCT07697677","Modified Mini-PCNL Versus Standard PCNL for Complex Kidney Stones","Modified Mini Percutaneous Nephrolithotomy Versus Standard Percutaneous Nephrolithotomy for the Treatment of Complex Renal Calculi: A Multicenter Randomized Controlled Trial","MIMIC-PCNL","Inclusion Criteria:\n\n1. Adults aged ≥18 years.\n2. Serum creatinine ≤133 μmol\u002FL.\n3. American Society of Anesthesiologists (ASA) physical status classification I-III.\n4. S.T.O.N.E. score ≥8.\n5. Complex renal stones confirmed by noncontrast computed tomography, including stone surface area \\>1500 mm², multiple calyceal stones, partial or complete staghorn calculi, or complex anatomical conditions.\n6. Patients who provide written informed consent and agree to undergo either modified mini-percutaneous nephrolithotomy or standard percutaneous nephrolithotomy.\n\nExclusion Criteria:\n\n1. Solitary kidney.\n2. Morbid obesity (body mass index ≥35 kg\u002Fm²).\n3. Previous renal transplantation or urinary diversion.\n4. Congenital abnormalities of the urinary tract.\n5. Pregnancy.\n6. Uncorrected coagulopathy.\n7. Active urinary tract infection.","ALL","18 Years","70 Years",{"count":22,"type":23},1380,"ESTIMATED","INTERVENTIONAL",[26],"NA","Kidney stones that are large or complex are often treated with percutaneous nephrolithotomy, also called PCNL. Standard PCNL uses a larger access tract and is effective for removing complex kidney stones, but it may be associated with more bleeding, pain, and recovery burden. Modified mini-PCNL uses a smaller access tract and may reduce surgical trauma while maintaining a similar stone clearance rate.\n\nThis multicenter randomized trial will compare modified mini-PCNL using a 20 Fr access sheath with standard PCNL using a 24 Fr access sheath in adults with complex renal stones. About 1,380 participants from 8 urology centers will be randomly assigned to receive one of the two procedures. The main purpose of the study is to determine whether modified mini-PCNL is not worse than standard PCNL in achieving stone-free status shortly after surgery. Stone-free status will be assessed by low-dose noncontrast CT within 72 hours after surgery. The study will also compare stone-free status at 3 months, complications, operation time, length of hospital stay, need for additional procedures, and quality of life.",[29,30],"Kidney Stones","Complex Renal Calculi",[32,33,34,35,36,37,38],"Percutaneous Nephrolithotomy","Mini-PCNL","Standard PCNL","Modified Mini-PCNL","Complex Renal Stones","Stone-Free Rate","Randomized Controlled Trial","RECRUITING","2026-07-07",{"date":42,"type":43},"2026-07-13","ACTUAL",{"date":45,"type":23},"2026-07-15",{"date":47,"type":23},"2027-09-14",{"name":49,"class":50},"The First Affiliated Hospital of Guangzhou Medical University","OTHER",1,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":24,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":51},"100613909","pmcf-investigation-of-modulith-slx-f2-with-storm-track-in-patients-with-kidney-stones-100613909","NCT07272720","PMCF Investigation of MODULITH® SLX-F2 With StorM-Track in Patients With Kidney Stones","Post-Market Clinical Follow-Up Investigation of MODULITH® SLX-F2 With StorM-Track in Patients With Kidney Stones - A Confirmatory Parallel-Group, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Single kidney stone (6 - 15 mm) in the target kidney\n3. Stone density assessed by Hounsfield unit value (HU) ≤ 1,200 HU\n\nExclusion Criteria:\n\n1. BMI \\> 34.9\n2. Target stone that cannot be localised\n3. Presence of one or more additional stones \\> 4 mm in the target kidney\n4. Presence of one or more additional stones ≤ 4 mm located in the same calyx (upper, mid, or lower pole) or in the renal pelvis as the target stone\n5. Stones with a density value of \\> 1,200 HU\n6. Skin to stone distance (SSD) \\> 160 mm\n7. The presence of obstructions, malformations or other factors preventing targeting or passing of the stone, including but not limited to the following:\n\n   1. Skeletal malformations and obesity, preventing targeting of the stone\n   2. Malignant tumour in the shockwave path\n   3. Arterial aneurysm or calcium deposits, or thrombosis in shockwave path\n   4. Brain, spinal column or air-filled tissue, especially the lungs, in the shockwave path\n   5. Obstruction distal to the stone (as this would hinder the passage of fragments through collecting system or ureter)\n8. Any disease\u002Fmedical condition, prior or concomitant medication\u002Ftreatment\u002Fintervention, or implant that may affect this clinical investigation, and\u002For is contraindicated for the IMD, including but not limited to the following:\n\n   1. Severe nephrocalcinosis\n   2. Uncontrolled urinary tract infection\n   3. Coagulation disorders and bleeding diathesis, not compensated according to urological and hemostaseological guidelines\n   4. Anticoagulation or platelet inhibition therapy, not bridged according to urological and hemostaseological guidelines\n   5. Uncontrolled hypertension\n   6. Blood pressure \\> 180\u002F100\n   7. Active cardiac implants that are not authorized for use with ESWL\n   8. Pancreatitis\n   9. Ehlers-Danlos syndrome\n   10. Administration of contrast agents containing gases for ultrasound diagnostics less than 24 hours before treatment.\n9. Pregnancy",{"count":60,"type":23},126,[26],"Extracorporeal shockwave lithotripsy (ESWL) is a non-invasive standard treatment for kidney stones.\n\nThis study will be conducted to evaluate the effectiveness of ESWL using MODULITH® SLX-F2 with stone tracking, compared to MODULITH® SLX-F2 without stone tracking, in adult patients with kidney stones, as measured by stone-free status.",[29,64],"Urolithiasis",[66,64,67,68],"Kidney stones","Extracorporeal shockwave lithotripsy","ESWL","2026-06-24",{"date":71,"type":43},"2026-06-29",{"date":73,"type":43},"2025-12-11",{"date":75,"type":23},"2028-10",{"name":77,"class":78},"Storz Medical AG","INDUSTRY",{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":24,"phases":89,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":51},"100636692","ureteral-access-sheaths-in-endoscopic-kidney-stone-surgery-100636692","NCT07568990","Ureteral Access Sheaths in Endoscopic Kidney Stone Surgery","The Impact of Two Different Ureteral Access Sheaths on Success and Complications in Endoscopic Kidney Stone Surgery","Inclusion Criteria:\n\n* Patients aged between 18 and 75 years\n* Patients diagnosed with kidney stones smaller than 2 cm\n* Patients scheduled for retrograde intrarenal surgery (RIRS)\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Patients with active urinary tract infection\n* Patients with coagulopathy\n* Pregnant patients\n* Patients unable to tolerate the lithotomy position\n* Patients with incomplete clinical or laboratory data","75 Years",{"count":88,"type":23},70,[26],"This prospective, randomized, comparative study aims to evaluate the impact of aspirating and non-aspirating ureteral access sheaths on success rates and complications in patients undergoing retrograde intrarenal surgery (RIRS) for kidney stones. A total of 70 patients with renal stones smaller than 2 cm will be enrolled and randomly assigned to two groups. One group will undergo RIRS using a non-aspirating ureteral access sheath, while the other group will be treated using an aspirating ureteral access sheath.\n\nThe primary outcome of the study is the stone-free rate, which will be assessed at postoperative follow-up. Secondary outcomes include operative time, fluoroscopy time, length of hospital stay, postoperative complications according to the Clavien-Dindo classification, infection-related parameters, and the need for ureteral stenting.\n\nThe study aims to determine whether the use of an aspirating access sheath improves surgical outcomes by reducing intrarenal pressure, enhancing visualization, and decreasing complication rates. The findings are expected to contribute to optimizing device selection and improving clinical outcomes in endoscopic kidney stone surgery.",[29],[93,94,95],"retrograd intrarenal surgery","kidney stone","kidney","2026-06-07",{"date":98,"type":43},"2026-06-10",{"date":100,"type":43},"2026-04-20",{"date":102,"type":23},"2027-05-11",{"name":104,"class":50},"Hitit University",{"id":106,"slug":107,"hasResults":12,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":112,"sex":18,"minAge":19,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":24,"phases":116,"briefSummary":117,"conditions":118,"keywords":126,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":137},"100592122","endogenous-oxalate-synthesis-in-idiopathic-calcium-oxalate-kidney-stone-disease-100592122","NCT06989320","Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease","Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Formers","Inclusion Criteria:\n\n* age 18-80 yrs\n* Body Mass Index \\> 18.5 kg\u002Fm2\n* Normal fasting serum electrolytes on comprehensive metabolic profile\n* Willing to ingest fixed diets\n* Willing to stop supplements (vitamins including vitamin C, calcium (citrate or carbonate) and other minerals, herbal supplements, nutritional aids, probiotics) for 2 weeks before start and during study.\n* For stone formers: first time or recurrent Calcium Oxalate stone former. Composition of most recent stone ≥ 50% calcium oxalate if available, uric acid component \\\u003C20%\n\nExclusion Criteria:\n\n* Chronic Kidney Disease stage 4-5\n* Primary hyperoxaluria, Enteric (secondary) hyperoxaluria\n* Liver, bowel, endocrine or renal diseases (other than idiopathic Calcium Oxalate kidney stones) or any other condition that may influence the absorption, transport or urinary excretion of ions, which will compromise the interpretation of results, including: Cystic fibrosis, Celiac disease, Cystinuria, Uric acid stone former, Nephrotic syndrome, Sarcoidosis, Renal tubular acidosis, Primary hyperparathyroidism, Neurogenic bladder, Urinary diversion, Chronic diarrhea, Bariatric surgery, Inflammatory bowel disease\n* Pregnancy or breast-feeding\n* Incompatible dietary requirements with the study, food allergies or intolerance to any of the foods in study menus\n* Active malignancy or treatment for malignancy within 12 months prior to screening\n* Utilization of immunosuppressive medication\n* Uncontrolled hypertension or diabetes\n* Diabetes type 1",true,"80 Years",{"count":115,"type":23},80,[26],"The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased production of oxalate by the body, which would lead to increased urinary excretion of oxalate.\n\nThe study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones.\n\nParticipants will\n\ningest fixed diets containing low amounts of oxalate for 5 days ingest a soluble form of glycolate and vitamin C collect urine, blood, stool during the dietary and oral dosing portions of the study and also collect breath sample during the oral glycolate test",[29,119,64,120,121,122,123,124,125],"Kidney Calculi","Urolithiasis, Calcium Oxalate","Nephrolithiasis","Nephrolithiasis, Calcium Oxalate","Oxalate Urolithiasis","Healthy","Healthy Volunteer",[127],"oxalate synthesis","2026-05-27",{"date":130,"type":43},"2026-05-29",{"date":132,"type":43},"2025-05-27",{"date":134,"type":23},"2031-12-31",{"name":136,"class":50},"University of Alabama at Birmingham",2,{"id":139,"slug":140,"hasResults":12,"nctId":141,"briefTitle":142,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":112,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":24,"phases":146,"briefSummary":147,"conditions":148,"keywords":149,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":51},"100606265","evaluation-of-eye-gaze-sharing-in-the-operating-room-100606265","NCT07173309","Evaluation of Eye Gaze Sharing in the Operating Room","Inclusion Criteria:\n\n* Surgeons who are \"adult\" residents and attending urologists at Vanderbilt University Medical Center in the age range 18 to 65\n* Patients who are adults with kidney stones scheduled for endoscopic surgery as clinically indicated.\n\nExclusion Criteria:\n\n* Vulnerable populations, including incarceration status, pregnancy, inability to give informed consent, and serious illness likely to cause death within 5 years",{"count":145,"type":23},110,[26],"This project aims to develop an augmented reality (AR) tool to enhance skill acquisition for endoscopic kidney stone surgery. Of the 100,000 patients who undergo an endoscopic kidney stone treatment annually in the United States, 25% will require a repeat stone surgery within 20 months of their index surgery. The repeat stone surgery rate is almost completely driven by postoperative residual stone fragments, which lead to ureteral obstruction, causing pain, urinary tract infection, and kidney injury. One significant factor that contributes to residual stone fragments is limited visualization of the entire collecting system - a skill directly associated with surgeon experience. This leads to novice surgeons having a much higher recurrence rate than experienced ones. As the incidence of kidney stone disease continues to increase (prevalence of 10%, incidence of 1116 per 100,000), improved endoscopic surgical training is required to improve outcomes of stone surgeries and minimize complications by improving stone-free rate.\n\nCurrently, skill assessment during endoscopic stone surgery is limited. There are no objective metrics for endoscopic surgery to assess skill. The only feedback trainees get is in the form of verbal communication from expert surgeons, usually after the conclusion of surgery. Thus, most feedback is synoptic and limited in facilitating skill acquisition. Operative time and patient safety concerns restrict the amount of active, real-time feedback given during a case for skill acquisition. Endoscopic kidney stone surgery is uniquely challenging given the small depth and field of view of current endoscopes, which complicate the complete visualization of the entire collecting system.\n\nNavigation of the collecting system relies on mentally mapping preoperative imaging to the endoscopic surgical field. Success in mapping relies on hand-eye coordination, memory, and spatial reasoning, which are gained through practice. Thus, there is a need for tools that facilitate endoscopic surgical skill acquisition.\n\nThe overarching hypothesis for this research is that surgical skill acquisition and outcomes for endoscopic kidney stone surgery can be improved by analyzing eye gaze data and using expert gaze to guide surgical trainees intraoperatively. Eye gaze guidance has been shown to lead to better skill acquisition in virtual reality surgical tasks compared with motion guidance alone. The proposed system would provide real-time education for trainees during endoscopic stone surgery, such as through head-mounted displays (i.e., the Microsoft HoloLens 2). The investigators have previously demonstrated eye gaze sharing in phantoms. By implementing this system in the operating room (OR), the investigators would be able to instill durable skill acquisition in trainees. The investigators will also implement the NASA-task load index for the trainees to gauge the usability of the system.",[29],[29,150,151],"Augmented Reality","Gaze Guidance","2026-05-19",{"date":154,"type":43},"2026-05-22",{"date":156,"type":43},"2025-01-31",{"date":158,"type":23},"2026-08-31",{"name":160,"class":50},"Vanderbilt University Medical Center",{"id":162,"slug":163,"hasResults":12,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":169,"targetDuration":4,"studyType":24,"phases":171,"briefSummary":172,"conditions":173,"keywords":176,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":189},"100600770","trial-of-ureteroscopy-vs-steerable-continuous-flow-aspiration-technology-100600770","NCT07101809","Trial of Ureteroscopy vs Steerable Continuous Flow Aspiration Technology","Evaluating the Safety and Effectiveness of Steerable Ureteroscopic Renal Evacuation (SURE) With the CVAC® System Compared to Standard Ureteroscopy With no Suction for the Treatment of Renal Stones: a Prospective, Randomized Trial","TRUST","Inclusion Criteria:\n\n* Candidate for ureteroscopy with laser lithotripsy\n* Be willing and able to return for and respond to all study-related follow up procedures\n* Have been informed of the nature of the study and has provided informed consent using the IRB approved informed consent (ICF)\n\nExclusion Criteria:\n\n* Untreated urinary tract infection at the time of the index procedure\n* Significant comorbidities\n* Bladder, ureteral or kidney abnormalities\n* Pregnant individuals\n* Unable to meet the treatment and follow up protocol requirements",{"count":170,"type":23},150,[26],"The goal of this clinical trial is to compare Steerable Ureteroscopic Renal Evacuation (SURE) using the CVAC System and standard ureteroscopy (URS) with laser lithotripsy for the treatment of urolithiasis. This is a prospective, randomized (1:1), multi-center study.",[64,174,175,29],"Stones, Kidney","Renal Stones",[177,178,179],"ureteroscopy","CVAC","SURE","2026-05-18",{"date":182,"type":43},"2026-05-20",{"date":184,"type":23},"2026-05",{"date":186,"type":23},"2029-07",{"name":188,"class":78},"Calyxo, Inc.",3,{"id":191,"slug":192,"hasResults":12,"nctId":193,"briefTitle":194,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":112,"sex":18,"minAge":19,"maxAge":196,"enrollmentInfo":197,"targetDuration":4,"studyType":24,"phases":199,"briefSummary":200,"conditions":201,"keywords":202,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":51},"100471337","oxalate-driven-host-responses-in-kidney-stone-disease-100471337","NCT05417568","Oxalate-Driven Host Responses in Kidney Stone Disease","Inclusion Criteria:\n\n* Men and women between the ages of 18 and 60 years old.\n* Able to provide informed consent.\n* BMI between 20-30 kg\u002Fm2.\n* Non-tobacco users or not pregnant\u002Fbreastfeeding\u002Fnursing.\n* Normal fasting blood comprehensive metabolic panel, complete blood count, C-reactive protein, and urinalysis. Must accurately collect two 24-hour urine collections within 20% of the appropriate ratio of creatinine (mg)\u002Fbody weight (kg) for respective gender.\n* Healthy subjects: No history of CaOx KS or other medical conditions.\n* Patients with CaOx KS: Recent stone composition \\> 50% CaOx; no uric acid, struvite, or carbonate apatite stone content. Must be first-time or recurrent CaOx stone former (last stone event ≤ 3 years).\n* Willing to not consume supplements (i.e. vitamins, Ca (citrate or carbonate) and other minerals, herbal supplements, nutritional aids, and probiotics) for 2 weeks before the study and during the study.\n* Willing to abstain from vigorous exercise during the study as this may compromise immune function.\n* Willing to consume diets provided only by the UAB CCTS Bionutrition Core. No food allergies or intolerance to any of the foods on the study menus.\n* Willing to accurately collect 24-hour urine samples, and to have blood drawn throughout the study.\n* If on medications for KS prevention (e.g. thiazides, citrate supplementation excluding calcium citrate), patients must be on a stable dose regimen for at least 8 weeks prior to and during screening, with no changes in dosing anticipated during the study. Patients should not take allopurinol for 2 weeks prior to screening since allopurinol has antioxidant properties.\n\nExclusion Criteria:\n\n* Failure to meet the inclusion criteria or physician refusal.\n* Inability to sign and read the informed consent.\n* Any medical, psychiatric, or social conditions that would prohibit participants from abiding by the study requirements.\n* BMI ˃30 kg\u002Fm2 and \\\u003C20 kg\u002Fm2\n* Tobacco users or pregnant or breastfeeding\u002Fnursing women.\n* Abnormal fasting blood comprehensive metabolic panel, complete blood count, C-reactive protein, and urinalysis. Inaccurate 24-hour urine collections.\n* Healthy subjects: Currently taking or have recently taken medications within the last 3 months (i.e. antibiotics) or dietary supplements. History of KS or any medical condition that could influence absorption or excretion of oxalate.\n* Active illness including COVID-19, flu, common cold, fever, diarrhea, urinary tract infections, or other infections 14 days before the study and throughout the study.","60 Years",{"count":198,"type":23},88,[26],"This study is looking to understand the role of oxalate on kidney stone development and immunity. This study will enroll healthy participants and participants with calcium oxalate kidney stones (CaOx KS). Participants will be in this study for about 3 weeks, consume controlled diets, and provide blood and urine specimens.",[29],[66,203],"Dietary oxalate","2026-05-12",{"date":206,"type":43},"2026-05-15",{"date":208,"type":43},"2023-05-19",{"date":210,"type":23},"2027-05-30",{"name":136,"class":50},{"id":213,"slug":214,"hasResults":12,"nctId":215,"briefTitle":216,"officialTitle":216,"acronym":4,"eligibilityCriteria":217,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":218,"targetDuration":4,"studyType":24,"phases":220,"briefSummary":221,"conditions":222,"keywords":223,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":229,"leadSponsor":231,"locationsCount":51},"100615763","surgical-outcomes-and-costs-in-using-the-shenzhen-hugemed-63-french-flexible-ureteroscope-100615763","NCT07296835","Surgical Outcomes and Costs in Using the Shenzhen HugeMed 6.3 French Flexible Ureteroscope","Inclusion Criteria:\n\n* Males or females ≥ 18 years of age\n* Patients with ureteral or kidney stones undergoing primary flexible ureteroscopy for retrograde intrarenal surgery\n* Total stone burden ≤ 2.5 cm\n\nExclusion Criteria:\n\n* Undergoing bilateral stone treatment during the same procedure\n* Patients with known genitourinary anatomical abnormalities that would complicate the procedure as determined by the treating investigator\n* Uncorrected coagulopathy\n* Patients with urinary diversions\n* Chronic external urinary catheters\n* Women who are pregnant\n* Immunosuppressed patients\n* Non-elective procedures\n* Participants must not be involved in any other clinical research studies during the duration of this trial. Exceptions may be made if the investigator determines, on a case-by-case basis, that participation in another study will not adversely affect the outcomes or integrity of this trial",{"count":219,"type":23},75,[26],"Comprehensive comparative investigations between HugeMed HU30M 6.3 Fr f-URS and traditional approach f-URS devices in RIRS are lacking in an American population. The investigators aim to compare the outcomes of using the 6.3 Fr f-URS versus traditional approach (other f-URS present in our institution) to treat patients with stone burden ≤ 2.5 cm. The findings of this study will expand on the potential advantages and drawbacks of HU30M in enhancing surgical outcomes and patient safety in RIRS procedures. We hypothesize that the use of the HU30M will result in increased cost savings while providing similar stone free rates when compared to traditionally used f-URS devices.",[29],[224],"hugemed, coast saving, ureteroscopy","2026-05-01",{"date":227,"type":43},"2026-05-06",{"date":225,"type":23},{"date":230,"type":23},"2028-11",{"name":232,"class":50},"University of Kansas Medical Center",{"id":234,"slug":235,"hasResults":12,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":240,"targetDuration":4,"studyType":24,"phases":241,"briefSummary":242,"conditions":243,"keywords":244,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":51},"100598523","comparing-efficiency-and-stone-free-rates-mini-pcnl-vs-flex-urs-100598523","NCT07072598","Comparing Efficiency and Stone-Free Rates Mini PCNL vs Flex URS","Comparing Efficiency and Stone-Free Rates After Mini-Percutaneous Nephrolithotomy and Flexible Ureteroscopy With Suction Access Sheaths","Inclusion Criteria:\n\n* Patients 18 years or older\n* Have a CT scan showing renal stones 1-3cm in length\n* Patients who will be able to read, understand, and complete patient questionnaires\n\nExclusion Criteria:\n\n* Pregnant individuals\n* Those with anomalous renal anatomy\n* Patients with a urinary diversion (ex: Ileal conduit, reservoir, bladder substitute, etc.)\n* Any condition rendering patient medically unfit to undergo either procedure (Bleeding diasthesis)\n* Patients who lack decisional capacity\n* Patients who are non-english speakers\\*\n\n  * Non-recruitment of non-english speakers is due to the study being a small pilot study that is used to assess the stone free rate for patients treated with a ureteroscopy or mini-PCNL using ClearPETRA suction access sheaths in a small portion of our patient population seeking treatment for stones. The team also does not possess the bandwidth or personnel to consent patients who are non-English speaking.",{"count":115,"type":23},[26],"The objective of the study is to compare the stone free rates with ureteroscopy utilizing the ClearPETRA suction ureteral access sheath, and mini-PCNL; both procedures and ClearPETRA sheaths are standard of care and are used regularly for stone treatment. Our primary objective is to assess the complete stone free rate with both procedures.",[29,121,64],[94,245,33,246,247,248],"Ureteroscopy","ClearPETRA","kidney stone interventional treatment","kidney stone 1cm-3cm","2026-04-26",{"date":251,"type":43},"2026-04-30",{"date":253,"type":23},"2026-04-25",{"date":255,"type":23},"2027-12",{"name":257,"class":50},"Northwestern University",{"id":259,"slug":260,"hasResults":12,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":4,"eligibilityCriteria":264,"healthyVolunteers":12,"sex":18,"minAge":265,"maxAge":113,"enrollmentInfo":266,"targetDuration":4,"studyType":24,"phases":268,"briefSummary":269,"conditions":270,"keywords":272,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":282,"leadSponsor":284,"locationsCount":51},"100634099","effect-of-complete-suction-induced-collapse-of-the-renal-collecting-system-at-the-end-of-rirs-on-early-postoperative-outcomes-100634099","NCT07535281","Effect of Complete Suction-Induced Collapse of the Renal Collecting System at the End of RIRS on Early Postoperative Outcomes","Effect of Complete Suction-Induced Collapse of the Renal Collecting System at the End of Retrograde Intrarenal Surgery on Early Postoperative Outcomes: A Prospective Randomized Study","Inclusion Criteria:\n\n* Patients aged 20 to 80 years.\n* Patients diagnosed with kidney stones and scheduled for retrograde intrarenal surgery (RIRS).\n* Patients who have voluntarily signed the written informed consent form\n\nExclusion Criteria:\n\n* Participation in another clinical trial (drug or device) within 1 month prior to enrollment.\n* Congenital abnormalities of the urinary or reproductive system.\n* Presence of a pre-placed ureteral stent (pre-stenting) at the time of surgery.\n* Solitary kidney.\n* Uncontrolled urinary tract infection.\n* History of ureteral reconstruction on the affected side.\n* Pregnancy.\n* Uncorrectable bleeding diathesis or ongoing therapeutic anticoagulation therapy.\n* Contraindications to general anesthesia.\n* Other conditions that the investigator deems inappropriate for participation in the study.","20 Years",{"count":267,"type":23},90,[26],"The purpose of this study is to evaluate whether actively suctioning the renal collecting system to induce a \"collapse\" state at the end of retrograde intrarenal surgery (RIRS) can reduce postoperative pain and infection in patients with kidney stones. Participants will be randomly assigned to either the experimental group (suction-induced collapse) or the control group (standard drainage). The study aims to determine if this simple surgical modification can improve early recovery outcomes and patient satisfaction.",[29,121,271],"Renal Calculi",[273,274,275,276,277,278],"retrograde intrarenal surgery","ureteral access sheath","suction","postoperative pain","infectious complications","renal collecting system",{"date":280,"type":43},"2026-04-23",{"date":100,"type":43},{"date":283,"type":23},"2027-09",{"name":285,"class":50},"Kangdong Sacred Heart Hospital",{"id":287,"slug":288,"hasResults":12,"nctId":289,"briefTitle":290,"officialTitle":290,"acronym":4,"eligibilityCriteria":291,"healthyVolunteers":112,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":292,"targetDuration":4,"studyType":24,"phases":294,"briefSummary":295,"conditions":296,"keywords":298,"overallStatus":301,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":304,"completionDateStruct":305,"leadSponsor":307,"locationsCount":51},"100622869","the-effect-of-apple-cider-vinegar-supplementation-on-24-hour-urine-chemistry-in-adults-100622869","NCT07389226","The Effect of Apple Cider Vinegar Supplementation on 24-hour Urine Chemistry in Adults","Inclusion Criteria:\n\n* Controls: Adults above the age of 18.\n* Kidney stone patients: Adults above the age of 18.\n* History of majority (\\>50%) calcium oxalate kidney stones\n\nExclusion Criteria:\n\n* Anyone with a history of calcium phosphate stones (\\>50% calcium phosphate), uric acid stones, struvite stones, recent urinary tract instrumentation (\\\u003C30 days), or recurrent urinary tract infections.\n* Any individual who has had ACV outside of normal consumption in the prior month will be excluded.\n* Any individual who has a history of a negative reaction (increased acid reflux, allergy) to ACV will also be excluded.\n* Any individual with chronic kidney disease, underlying acid base disorder will also be excluded.",{"count":293,"type":23},30,[26],"This is a single-center prospective cohort study to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.",[29,297],"Urine Specimen Collection",[299,300],"urine specimen collection","kidney stones","NOT_YET_RECRUITING","2026-04-17",{"date":100,"type":43},{"date":184,"type":23},{"date":306,"type":23},"2028-02",{"name":308,"class":50},"University of Chicago",{"id":310,"slug":311,"hasResults":12,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":4,"eligibilityCriteria":315,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":316,"targetDuration":4,"studyType":24,"phases":318,"briefSummary":319,"conditions":320,"keywords":4,"overallStatus":301,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":327,"locationsCount":51},"100617711","pilot-study-of-patient-navigation-for-kidney-stone-patients-after-ed-visits-100617711","NCT07322172","Pilot Study of Patient Navigation for Kidney Stone Patients After ED Visits","Pilot Study of Patient Navigation Intervention to Improve Follow-up Care for Patients With Urinary Stone Disease","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Presentation to the Emergency Department with urinary stone disease\n* Placement of an outpatient urology referral from the Emergency Department\n* Identified as high risk for loss to follow-up based on the study's screening process\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Unable to provide informed consent\n* Non-English-speaking\n* No outpatient urology referral placed from the Emergency Department",{"count":317,"type":23},31,[26],"Patients who visit the emergency department for kidney stones are sometimes referred to urology for follow-up care but never complete that visit. Missing follow-up appointments can lead to worse outcomes, including recurrent pain, infection, or surgery. Research shows that patients who are socially or economically at risk (such as those with public insurance, lower income, or limited English proficiency) are more likely to experience these care gaps.\n\nThis study will pilot a patient navigation program designed to help patients with urinary stone disease (USD) attend their scheduled urology appointments after being seen in the Emergency Department. Using an electronic health record (EHR) based prediction model developed in earlier research, patients at higher risk for being lost to follow-up will be identified and invited to participate. Each participant will be paired with a trained patient navigator who will assess barriers to care, provide support, and maintain contact for about 12 weeks.\n\nThe goal of this study is to evaluate the outcomes and feasibility of this navigation intervention. Findings will help determine whether a larger study should test if this approach improves access to care and health outcomes for patients with kidney stones.",[29],"2026-04-06",{"date":323,"type":43},"2026-04-08",{"date":325,"type":23},"2026-07",{"date":325,"type":23},{"name":328,"class":50},"University of California, San Francisco",{"id":330,"slug":331,"hasResults":12,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":335,"eligibilityCriteria":336,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":86,"enrollmentInfo":337,"targetDuration":4,"studyType":24,"phases":339,"briefSummary":341,"conditions":342,"keywords":344,"overallStatus":301,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":350,"completionDateStruct":352,"leadSponsor":354,"locationsCount":51},"100632331","phase-4-pain-control-during-eswl-using-non-opioid-analgesics-100632331","NCT07512297","Pain Control During ESWL Using Non-Opioid Analgesics","Comparative Evaluation of Non-Opioid Analgesics for Pain Control During Extracorporeal Shock Wave Lithotripsy: A Prospective Randomized Controlled Trial","ESWL-PAIN","Inclusion Criteria:\n\n* Adult patients (≥18 years) undergoing ESWL for urinary stone disease\n* Patients with kidney or ureteral stones indicated for ESWL\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Known hypersensitivity or contraindication to ibuprofen, paracetamol, or tenoxicam\n\n  * Chronic pain conditions or regular use of analgesics\n  * Pregnancy or breastfeeding\n  * Severe renal or hepatic impairment\n  * Patients unable to complete pain assessment using VAS",{"count":338,"type":23},160,[340],"PHASE4","This prospective randomized controlled trial aims to compare the analgesic efficacy of three non-opioid analgesics (ibuprofen, paracetamol, and tenoxicam) during extracorporeal shock wave lithotripsy (ESWL). All patients undergoing ESWL will be randomly assigned into four groups including a placebo group.\n\nPain intensity will be assessed using the Visual Analog Scale (VAS) at the 5th, 10th, 15th, and 20th minutes during the procedure. In addition to comparing analgesic efficacy, the study will evaluate patient-related and stone-related factors affecting pain perception, including body mass index, subcutaneous fat thickness, and stone density measured by Hounsfield Units.\n\nThe study also aims to assess the relationship between analgesic efficacy, energy levels applied during ESWL, and treatment outcomes such as stone-free rates. The findings may contribute to optimizing individualized pain management strategies and improving treatment efficiency in ESWL procedures.",[64,29,343],"Ureteral Stones",[68,345,346],"pain","Analgesia","2026-04-05",{"date":349,"type":43},"2026-04-09",{"date":351,"type":23},"2026-04-01",{"date":353,"type":23},"2027-03-01",{"name":355,"class":50},"University of Gaziantep",{"id":357,"slug":358,"hasResults":12,"nctId":359,"briefTitle":360,"officialTitle":361,"acronym":4,"eligibilityCriteria":362,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":196,"enrollmentInfo":363,"targetDuration":4,"studyType":24,"phases":364,"briefSummary":365,"conditions":366,"keywords":367,"overallStatus":301,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":377,"startDateStruct":378,"completionDateStruct":379,"leadSponsor":381,"locationsCount":51},"100632657","diss-vs-fans-in-suction-assisted-rirs-for-medium-sized-renal-stones-100632657","NCT07516535","DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones","The Impact of Suction-Assisted RIRS (DISS Versus FANS) on Postoperative Infection Rate and Stone-Free Rate After Treatment of Medium Sized Renal Stones","Inclusion Criteria:\n\n* Adults aged 18 to 60 years\n* Radiologically confirmed renal stones measuring 2 to 3 centimeters\n* Eligible for retrograde intrarenal surgery\n* Normal renal function as evidenced by normal serum creatinine\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Active urinary tract infection at the time of enrollment\n* Bleeding disorders or coagulopathies that contraindicate surgical intervention\n* Anatomical malformations affecting the urinary tract\n* Solitary kidney\n* Inability or unwillingness to provide informed consent",{"count":60,"type":23},[26],"Kidney stones are a common health problem and may recur frequently, which can affect quality of life and kidney function. Retrograde intrarenal surgery (RIRS) is a minimally invasive treatment used for renal stones, but treatment of medium-sized stones may be associated with longer operative time, impaired visibility during surgery, residual stone fragments, and postoperative infectious complications caused by increased intrarenal pressure.\n\nSuction-assisted retrograde intrarenal surgery (RIRS) techniques have been developed to improve surgical efficiency and safety by facilitating continuous removal of stone fragments and helping control intrarenal pressure. Two commonly used suction-assisted approaches are direct in-scope suction (DISS) and flexible and navigable suction ureteric access sheath (FANS). However, there is limited prospective randomized evidence directly comparing these two techniques.\n\nThis randomized prospective clinical study aims to compare direct in-scope suction (DISS) versus flexible and navigable suction ureteric access sheath (FANS) in adult patients with medium-sized renal stones measuring 2 to 3 cm who are undergoing retrograde intrarenal surgery (RIRS). Participants will be randomly assigned to one of the two suction-assisted techniques. The study will evaluate whether flexible and navigable suction ureteric access sheath (FANS) provides better outcomes than direct in-scope suction (DISS) in terms of stone-free rate and postoperative infection rate.\n\nThe primary outcome is stone-free status assessed by postoperative imaging. Secondary outcomes include operative time, intraoperative visibility, and postoperative complications, particularly infection and urosepsis. The study hypothesis is that suction-assisted retrograde intrarenal surgery (RIRS) using the flexible and navigable suction ureteric access sheath (FANS) technique will result in a higher stone-free rate and a lower postoperative infection rate compared with direct in-scope suction (DISS) in the management of medium-sized renal stones.",[29,121,271],[368,369,370,37,371,372,373,374,375,376],"Retrograde Intrarenal Surgery","Suction-Assisted Retrograde Intrarenal Surgery","Medium-Sized Renal Stones","Postoperative Infection","Urosepsis","Flexible Ureteroscopy","Holmium Laser Lithotripsy","Ureteric Access Sheath","Intrarenal Pressure",{"date":323,"type":43},{"date":251,"type":23},{"date":380,"type":23},"2027-04-30",{"name":382,"class":50},"Ain Shams University",{"id":384,"slug":385,"hasResults":12,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":4,"eligibilityCriteria":389,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":390,"targetDuration":4,"studyType":24,"phases":392,"briefSummary":393,"conditions":394,"keywords":4,"overallStatus":301,"whyStopped":4,"lastUpdateSubmitDate":395,"lastUpdatePostDateStruct":396,"startDateStruct":398,"completionDateStruct":400,"leadSponsor":402,"locationsCount":51},"100632489","fans-vs-cvac-for-medium-to-large-stones-100632489","NCT07514351","FANS vs CVAC for Medium to Large Stones","Randomized Controlled Trial of Flexible and Navigable Suction (FANS) vs. CVAC Suction Ureteroscope for Medium to Large Stones","Inclusion Criteria:\n\n* Clinical diagnosis of Nephrolithiasis\n* Total linear stone diameter 8-20 mm in size\n\nExclusion Criteria:\n\n* Severe medical comorbidities causing inability to undergo general anesthesia",{"count":391,"type":23},159,[26],"Improvements in ureteroscopes have led to improved stone free rates. Two new devices (FANS - Flexible and Navigable Suction) and the CVAC ureteroscope have never been compared head to head. This trial will compare these two new suction ureteroscope technologies against each other",[29,121],"2026-03-31",{"date":397,"type":43},"2026-04-07",{"date":399,"type":23},"2026-06",{"date":401,"type":23},"2028-12",{"name":403,"class":50},"Ohio State University",{"id":405,"slug":406,"hasResults":12,"nctId":407,"briefTitle":408,"officialTitle":409,"acronym":4,"eligibilityCriteria":410,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":411,"targetDuration":413,"studyType":414,"phases":4,"briefSummary":415,"conditions":416,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":420,"completionDateStruct":422,"leadSponsor":424,"locationsCount":51},"100630782","effect-of-negative-pressure-suction-on-fluid-absorption-and-infection-in-flexible-ureteroscopy-100630782","NCT07492147","Effect of Negative Pressure Suction on Fluid Absorption and Infection in Flexible Ureteroscopy","Impact of Negative Pressure Suction on Irrigation Fluid Absorption and Postoperative Infection Risk During Flexible Ureteroscopic Lithotripsy: A Prospective Cohort Study","Inclusion Criteria:\n\n* Patients aged 18 years and older with kidney stones who meet the surgical indications for RIRS;\n* Patients who have provided informed consent.\n\nExclusion Criteria:\n\n* Concurrent combination with other surgical procedures, such as percutaneous nephrolithotomy (PCNL);\n* Patients with malignancies, urinary tuberculosis, immune system diseases, or hyperthyroidism;\n* Congenital renal anomalies, such as polycystic kidney disease or horseshoe kidney;\n* Presence of untreated urinary tract infections;\n* Inability to tolerate surgery due to severe cardiopulmonary dysfunction, hepatic or renal insufficiency, or coagulation abnormalities.",{"count":412,"type":23},400,"7 Days","OBSERVATIONAL","The goal of this observational study is to learn about the effects of using negative pressure suction during retrograde intrarenal surgery (RIRS) in patients aged 18 and older with kidney stones. The main questions it aims to answer are:\n\n1. Does using negative pressure suction during surgery affect the amount of irrigation fluid absorbed by the patient's body?\n2. Does using negative pressure suction reduce the risk of postoperative infections, such as fever, systemic inflammatory response syndrome (SIRS), and urosepsis? Researchers will compare patients who undergo surgery with a negative pressure suction sheath to patients who undergo surgery with a standard sheath (without suction) to see if the suction technology reduces fluid absorption and lowers the risk of postoperative complications.\n\nParticipants will undergo their scheduled kidney stone surgery as part of their regular medical care. Researchers will collect their routine clinical data from the hospital system, including:\n\n1. Preoperative test results (such as CT scans, ultrasounds, and urine tests).\n2. Intraoperative data (such as surgery duration and the exact amount of fluid absorbed, measured by a monitoring device).\n3. Postoperative recovery data (such as body temperature, pain levels, hospital stay length, and any signs of infection).",[29],"2026-03-19",{"date":419,"type":43},"2026-03-25",{"date":421,"type":43},"2026-03-09",{"date":423,"type":23},"2027-07-07",{"name":425,"class":50},"Lanzhou University Second Hospital",{"id":427,"slug":428,"hasResults":12,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":432,"eligibilityCriteria":433,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":434,"targetDuration":4,"studyType":414,"phases":4,"briefSummary":436,"conditions":437,"keywords":438,"overallStatus":301,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":447,"locationsCount":4},"100604860","stone-clearance-with-aspiration-vs-other-technologies-a-real-world-evidence-study-100604860","NCT07155005","Stone Clearance With Aspiration vs Other Technologies: a Real-world Evidence Study","Evaluating the Safety and Effectiveness of Steerable Ureteroscopic Renal Evacuation (SURE) With the CVAC® System Compared to Other Therapeutic Interventions for the Treatment of Renal Stones: a Prospective, Observational Trial","SCORE","Inclusion Criteria:\n\n* Candidate for ureteroscopy with laser lithotripsy or PCNL for the treatment of renal stones\n* Be willing and able to return for and respond to all study-related follow up procedures\n* Have been informed of the nature of the study and has provided informed consent using the IRB approved informed consent (ICF)\n\nExclusion Criteria:\n\n* Untreated urinary tract infection at the time of the index procedure\n* Visual evidence of infection at the time of the index procedure\n* History of sepsis\n* Significant comorbidities\n* Bladder, ureteral or kidney abnormalities\n* Pregnant individuals\n* Unable to meet the treatment and follow up protocol requirements",{"count":435,"type":23},1000,"The goal of this clinical trial is to evaluate the effectiveness and safety of Steerable Ureteroscopic Renal Evacuation (SURE) with the CVAC System versus other commonly used renal-stone interventions.",[64,174,175,29],[177,178,179,439],"URS","2026-03-11",{"date":442,"type":43},"2026-03-12",{"date":444,"type":23},"2026-03-16",{"date":446,"type":23},"2029-04",{"name":188,"class":78},{"id":449,"slug":450,"hasResults":12,"nctId":451,"briefTitle":452,"officialTitle":452,"acronym":453,"eligibilityCriteria":454,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":455,"enrollmentInfo":456,"targetDuration":4,"studyType":24,"phases":457,"briefSummary":458,"conditions":459,"keywords":460,"overallStatus":301,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":466,"startDateStruct":468,"completionDateStruct":470,"leadSponsor":472,"locationsCount":4},"100620574","dual-approach-external-oblique-fascial-plane-block-versus-erector-spinae-plane-block-for-post-operative-analgesia-in-percutaneous-nephrolithotomy-100620574","NCT07359391","Dual Approach External Oblique Fascial Plane Block Versus Erector Spinae Plane Block for Post Operative Analgesia in Percutaneous Nephrolithotomy","BLOCK-PCNL","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I or II\n\nBody mass index (BMI) between 18 and 35 kg\u002Fm²\n\nScheduled for unilateral percutaneous nephrolithotomy (PCNL)\n\nAbility to understand the study protocol and provide written informed conse\n\nExclusion Criteria:Refusal to participate\n\nKnown allergy or hypersensitivity to local anesthetics\n\nInfection at the site of block injection\n\nCoagulopathy or bleeding disorders\n\nChronic pain syndrome or long-term opioid use\n\nSevere hepatic, renal, or cardiac disease\n\n\\-","65 Years",{"count":267,"type":23},[26],"Here is a \\*\\*patient-friendly, ClinicalTrials.gov-compliant Brief Summary\\*\\* written in \\*\\*plain language\\*\\*, avoiding technical jargon as much as possible while remaining accurate.\n\nYou can \\*\\*copy-paste this directly\\*\\* into the \\*\\*Brief Summary\\*\\* field.\n\n* \\*\\*Brief Summary\\*\\*\n\nPercutaneous nephrolithotomy (PCNL) is a common surgical procedure used to remove large kidney stones. Patients often experience moderate to severe pain after this surgery due to the surgical incision and irritation of the kidney and surrounding tissues. Effective pain control after PCNL is important to improve patient comfort, reduce the need for opioid medications, and enhance recovery.\n\nSeveral regional anesthesia techniques have been developed to reduce postoperative pain. Two of these techniques are the dual-approach external oblique fascial plane block and the erector spinae plane block. Both techniques involve injecting a local anesthetic near specific muscle planes using ultrasound guidance to reduce pain signals from the surgical area. However, it is not yet clear which of these two techniques provides better pain relief after PCNL.\n\nThis study aims to compare the effectiveness of the dual-approach external oblique fascial plane block and the erector spinae plane block in controlling pain after PCNL surgery. Adult patients scheduled for PCNL will be randomly assigned to receive one of the two nerve block techniques or standard general anesthesia alone. Pain levels, additional pain medication requirements, patient satisfaction, and any block-related complications will be assessed during the first 24 hours after surgery.\n\nThe results of this study may help determine the most effective regional anesthesia technique for improving postoperative pain management in patients undergoing PCNL.",[29],[32,461,462,463,464],"Postoperative Analgesia","Dual Approach External Oblique Fascial Plane Block","Erector Spinae Plane Block","Pain Management","2026-01-14",{"date":467,"type":43},"2026-01-22",{"date":469,"type":23},"2026-01-12",{"date":471,"type":23},"2026-08",{"name":473,"class":474},"Zagazig University","OTHER_GOV",{"id":476,"slug":477,"hasResults":12,"nctId":478,"briefTitle":479,"officialTitle":480,"acronym":4,"eligibilityCriteria":481,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":482,"targetDuration":4,"studyType":24,"phases":484,"briefSummary":486,"conditions":487,"keywords":488,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":493,"lastUpdatePostDateStruct":494,"startDateStruct":495,"completionDateStruct":497,"leadSponsor":499,"locationsCount":51},"100597191","early-phase-1-sglt2i-in-kidney-stones-100597191","NCT07055282","SGLT2i in Kidney Stones","SGLT2i in Calcium Kidney Stones","Inclusion Criteria:\n\nCalcium phosphate (CaP) stone participants:\n\n* Age 18-70\n* History of at least one calcium phosphate (hydroxyapatite) stone\n\n  * Defined as at least 50% of stone material on most recent stone analysis\n\nCalcium oxalate (CaOx) stone participants:\n\n* Age 18-70\n* History of at least one calcium oxalate stone\n\n  * Defined as at least 50% of stone material on most recent stone analysis.\n\nOther inclusion criteria considerations: The investigators will study balanced numbers of male and females. Prior studies did not have balanced representation of male and female sexes. In prior studies, less than 40% were female, or sex data is not presented. Study of both male and female sex is crucial with kidney stones and therapies that affect citrate and pH because there are well established epidemiologic differences in stone type and physiologic differences in acid-base handling by sex. Epidemiologically, younger women are more likely to have CaP stones, and this is likely because they have higher urine pH.\n\nExclusion Criteria:\n\n* History of primarily brushite, uric acid, cysteine, or struvite stones\n* History of severe acid-base abnormality, very low (less than 100mg\u002Fday) or very high (greater than 1500mg\u002Fday) urine citrate\n* Participants who cannot stop diuretic medication or alkali supplementation for the course of the study period\n* Use of drugs that can directly affect proximal tubule function (e.g., topiramate)\n* Diagnosis of complete distal renal tubular acidosis\n* Diagnosis of chronic kidney disease (eGFR \\\u003C60 mL\u002Fmin\u002F1.73m²)",{"count":483,"type":23},32,[485],"EARLY_PHASE1","This study is looking at whether empagliflozin, a medication typically used for diabetes and heart conditions, may affect factors that contribute to kidney stone formation. The research focuses on people who have had calcium-based kidney stones, i.e. calcium oxalate or calcium phosphate stones.\n\nPrevious studies in those without kidney stones found that empagliflozin increased urinary citrate levels without raising urine pH. The investigators are testing whether similar effects occur in people with a history of kidney stones.\n\nParticipants will take empagliflozin daily for 4 weeks. The investigators will collect 24-hour urine samples before and after treatment to measure various factors that influence stone formation, including citrate levels, pH, and calculated stone formation risk. The investigators will enroll 32 participants: 16 with a history of calcium oxalate stones and 16 with calcium phosphate stones.\n\nResults from this study may inform future larger clinical trials investigating empagliflozin as a kidney stone prevention strategy.",[29],[300,489,490,491,94,492],"SGLT2i","empagliflozin","calcium kidney stones","calcium kidney stone","2026-01-08",{"date":469,"type":43},{"date":496,"type":43},"2025-11-20",{"date":498,"type":23},"2027-12-31",{"name":308,"class":50},{"id":501,"slug":502,"hasResults":12,"nctId":503,"briefTitle":504,"officialTitle":505,"acronym":4,"eligibilityCriteria":506,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":507,"targetDuration":4,"studyType":24,"phases":508,"briefSummary":509,"conditions":510,"keywords":511,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":514,"lastUpdatePostDateStruct":515,"startDateStruct":517,"completionDateStruct":519,"leadSponsor":521,"locationsCount":51},"100610298","phase-4-caox-stone-prevention-100610298","NCT07225764","CaOx Stone Prevention","Empiric vs Selective Medical Therapy for Calcium Oxalate Stone Prevention: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult age of 18 years\n* Diagnosed with kidney stones and scheduled for PCNL.\n* Calcium Oxalate Stone Former\n* Pre-operative CT-scan within 90 days of surgery and stone density with \\> 1000 Hounsfield units\n* Non-pregnant or breastfeeding\n* Able and willing to provide informed consent.\n* Pre-operative eGFR greater than 70 mL\u002Fmin\u002F1.73 m² -Negative pre-operative urine culture\n\nExclusion Criteria:\n\n* Documented history of gastric or intestinal bypass, liver disease, history of gastrointestinal malabsorptive disease (Crohn's disease, ulcerative colitis, and short-gut syndrome)\n* Hyperparathyroidism -Renal tubular acidosis\n* Active kidney stone prevention treatment (use of thiazides, alkaline therapy, or low oxalate diet) at the time of surgery\n* History of hypokalemia or baseline hypotension\n* Allergy to medications used in trial or sulfa-containing medications\n* Patient prescribed thiazide, loop diuretics, carbonic anhydrase inhibitors, xanthine oxidase inhibitors, active Vitamin D, bisphosphonates, denosumab, glucocorticoids, or potassium supplementation",{"count":115,"type":23},[340],"This single-center randomized controlled trial at Mount Sinai West will enroll 80 patients undergoing percutaneous nephrolithotomy for calcium oxalate stones. Participants will be randomized to receive either empiric therapy or selective therapy guided by 24-hour urine evaluation. The primary outcome is change in calcium oxalate supersaturation at 4 weeks, aiming to determine whether empiric therapy can provide outcomes comparable to selective therapy while simplifying access to prevention.",[29],[300,512,513],"calcium oxalate","nephrolithiasis","2025-11-05",{"date":516,"type":43},"2025-11-10",{"date":518,"type":43},"2025-10-23",{"date":520,"type":23},"2027-06-30",{"name":522,"class":50},"Icahn School of Medicine at Mount Sinai",{"id":524,"slug":525,"hasResults":12,"nctId":526,"briefTitle":527,"officialTitle":528,"acronym":4,"eligibilityCriteria":529,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":530,"targetDuration":4,"studyType":24,"phases":532,"briefSummary":533,"conditions":534,"keywords":537,"overallStatus":301,"whyStopped":4,"lastUpdateSubmitDate":540,"lastUpdatePostDateStruct":541,"startDateStruct":543,"completionDateStruct":545,"leadSponsor":547,"locationsCount":51},"100609207","the-larc-robot-simplifies-renal-access-in-percutaneous-nephrolithotomy-100609207","NCT07211555","The LARC Robot Simplifies Renal Access In Percutaneous Nephrolithotomy","The LARC Robot Simplifies Renal Access In Percutaneous Nephrolithotomy (PCNL)","Inclusion Criteria:\n\n* Kidney stones larger than 2 cm\n* Staghorn renal calculi\n* Lower pole stones less than 2 cm\n* Anatomical abnormalities that reduce the likelihood of spontaneous stone fragment passage, such as:\n* Horseshoe kidney\n* Calyceal diverticulum\n* Ectopic or dystopic kidney\n* Stones that are refractory to prior treatment (e.g., ESWL or ureteroscopy)\n* Suspected malignant tumors or masses located in the planned renal access tract\n\nExclusion Criteria:\n\n* Pregnancy\n* Active urinary tract infection (UTI) or untreated sepsis\n* Known bleeding disorders or uncorrectable coagulopathy despite medical management\n* Use of anticoagulant medications (e.g., warfarin, heparin, or DOACs) that cannot be safely discontinued\n* Allergy to contrast media that cannot be pre-medicated or managed\n* Severe cardiopulmonary comorbidities that contraindicate anesthesia or PCNL\n* Inability to provide informed consent\n* Participation in another investigational study that may interfere with study outcomes",{"count":531,"type":23},45,[26],"This study is being done to evaluate a new robotic system that helps urologists more precisely reach the kidney during surgery to remove large kidney stones. The procedure, called percutaneous nephrolithotomy (PCNL), is typically used for people who have large or difficult-to-remove kidney stones.\n\nTraditionally, many urologists rely on radiologists to place a tube into the kidney before surgery. This can cause delays, require multiple procedures, and increase costs. The robotic system being studied - called LARC - is designed to help the urologist safely and accurately guide a needle directly into the kidney during the surgery, without needing a separate procedure beforehand.\n\nThe robot uses live X-ray images to help align the instruments. Although parts of the robot have been approved by the U.S. FDA, the version used in this study is still investigational and not yet approved for this specific purpose.\n\nThe study will take place at AdventHealth Celebration and include up to 45 adult patients who are scheduled for PCNL surgery. Participants will be followed for up to 1 month after surgery, and doctors will look at outcomes such as the success of the procedure, the number of kidney stones removed, complications, time in surgery, and radiation exposure.\n\nThis research may help make kidney stone surgery safer, faster, and more effective in the future.",[535,119,536,29],"Renal Stone Disease","Refractory Kidney Stones",[538,539],"Robotic Surgery","Minimally Invasive Surgery","2025-09-30",{"date":542,"type":43},"2025-10-08",{"date":544,"type":23},"2025-11-01",{"date":546,"type":23},"2026-01-01",{"name":548,"class":50},"AdventHealth",{"id":550,"slug":551,"hasResults":12,"nctId":552,"briefTitle":553,"officialTitle":554,"acronym":4,"eligibilityCriteria":555,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":556,"targetDuration":4,"studyType":24,"phases":557,"briefSummary":558,"conditions":559,"keywords":4,"overallStatus":301,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":563,"completionDateStruct":565,"leadSponsor":566,"locationsCount":51},"100607852","flexible-ureteroscopy-versus-extracorporeal-shock-wave-lithotripsy-100607852","NCT07193940","Flexible Ureteroscopy Versus Extracorporeal Shock Wave Lithotripsy","Flexible Ureteroscopy Versus Extracorporeal Shock Wave Lithotripsy for Treatment of Lower Calyceal Renal Stones Less Than 15 mm: A Prospective Randomized Comparative Study","Inclusion Criteria:\n\n* Adults (≥18 y)\n* Lower-calyx stone\n* Less than or equal15 mm\n* Mean Hounsfield (HU) \\\u003C1000\n\nExclusion Criteria:\n\n* Pregnancy\n* Uncorrected coagulopathy\n* Active UTI\u002Fobstruction\n* Anatomical barriers to Flexible Ureteroscopy or extracorporeal shock wave lithotripsy coupling (e.g., prohibitive SSD\u002FBMI).\n* Cardiac devices contraindicating ESWL",{"count":88,"type":23},[26],"To compare the efficacy and safety of flexible ureterorenoscopy (fURS) versus extracorporeal shock wave lithotripsy (ESWL) in managing lower calyceal renal stones ≤15 mm and \\\u003C1000 HU.",[29],"2025-09-28",{"date":562,"type":43},"2025-10-02",{"date":564,"type":23},"2025-10",{"date":75,"type":23},{"name":567,"class":50},"Assiut University",{"id":569,"slug":570,"hasResults":12,"nctId":571,"briefTitle":572,"officialTitle":573,"acronym":4,"eligibilityCriteria":574,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":575,"targetDuration":4,"studyType":24,"phases":577,"briefSummary":578,"conditions":579,"keywords":580,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":583,"lastUpdatePostDateStruct":584,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":590,"locationsCount":51},"100571570","thulium-fiber-laser-tfl-vs-thulio-pulsed-thuliumyag-p-tmyag-100571570","NCT06721975","Thulium Fiber Laser (TFL) vs Thulio Pulsed Thulium:YAG (p-Tm:YAG)","Prospective Single-center Study Comparing Thulium Fiber Laser to Pulsed Thulium:YAG Laser in the Ureteroscopic Treatment of Nephrolithiasis","Inclusion Criteria:\n\n* Solitary renal stone 7 to 20 mm in size or in the case of multiple stones the conglomerate diameter (additive maximal diameter of all stones on axial imaging of computed tomography) of 7-20 mm is required\n* Must be a suitable operative candidate for flexible ureteroscopy per American Urological Association guidelines\n* Must be able to give consent\n* Bilateral ureteroscopy will be permitted but only the first side (per surgeon discretion) will be included in the study\n* Surgeons participating in the study must be urological attending surgeons or fellows with subspecialty training in Endourology\n\nExclusion Criteria:\n\n* Concomitant stones in the ureter\n* Prior ipsilateral upper urinary tract reconstructive procedures or history of ipsilateral ureteral stricture\n* Prior radiotherapy to the abdomen or pelvis\n* Neurogenic bladder or spinal cord injury\n* Pregnancy\n* Untreated UTI",{"count":576,"type":23},50,[26],"This research study is being conducted to assess the ability and efficiency of two laser systems to break up kidney stones during ureteroscopy with laser lithotripsy for kidney stone treatment.",[29,121],[581,582,513,94],"laser lithotripsy","laser","2025-08-01",{"date":585,"type":43},"2025-08-03",{"date":587,"type":43},"2024-08-01",{"date":589,"type":23},"2026-12-31",{"name":591,"class":50},"University of California, San Diego",{"id":593,"slug":594,"hasResults":12,"nctId":595,"briefTitle":596,"officialTitle":597,"acronym":598,"eligibilityCriteria":599,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":600,"targetDuration":4,"studyType":24,"phases":602,"briefSummary":603,"conditions":604,"keywords":605,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":610,"lastUpdatePostDateStruct":611,"startDateStruct":613,"completionDateStruct":615,"leadSponsor":617,"locationsCount":51},"100592681","ily-robotic-system-vs-manual-flexible-ureteroscopy-for-kidney-stone-treatment-100592681","NCT06996587","ILY Robotic System vs Manual Flexible Ureteroscopy for Kidney Stone Treatment","A Randomized Controlled Trial Comparing Efficacy, Ergonomics, and Safety of ILY Robotic System vs Manual Flexible Ureteroscopy in Patients Undergoing Laser Lithotripsy for Kidney Stones","iFURS","Inclusion Criteria:\n\n* Males or females ≥ 18 years old\n* Patients with a normal pelvicalyceal anatomy\n* Patients with renal stone diagnosis confirmed by noncontrast computed tomography regardless of stone size, location, and multiplicity\n* ASA score I-III\n* Intact mental and cognitive ability to provide informed consent and willingness to participate in the study with 30-day follow-up\n\nExclusion Criteria:\n\n* Children \\\u003C 18 and pregnant women\n* Patients with anatomically anomalous kidneys, known case of stricture or stenosis, or recent 3-month history of ureteroscopy (DJ stent placement only will be accepted) or known history of complicated ureteroscopy\n* Patients in whom stone measurement was not feasible on NCCT or those with concomitant ureteric stones.\n* ASA score IV\n* Mentally incapacitated patients unable to provide informed consent",{"count":601,"type":23},152,[26],"The goal of this clinical trial is to compare the efficacy, ergonomics, and safety of robotic versus manual flexible ureteroscopy (fURS) for kidney stone treatment in adult patients undergoing laser lithotripsy.\n\n* Does robotic-assisted lithotripsy using the ILY® robot have the same efficacy as the manual fURS in treating kidney stones?\n* Is robotic flexible ureteroscopy associated with similar or improved safety outcomes, including perioperative and 30-day postoperative complication rates?\n* Does the robotic system offer improved ergonomics, lower surgeon radiation exposure, and favorable intraoperative metrics compared to manual flexible ureteroscopy? Researchers will compare the ILY robotic system with manual fURS to see if robotic intervention can match or improve clinical and ergonomic outcomes.\n\nParticipants will:\n\n* Be randomly assigned to undergo laser lithotripsy with either the ILY robot or manual flexible ureteroscopy\n* Complete standard pre- and postoperative assessments\n* Undergo evaluation for stone-free status using a non-contrast CT scan at 30 days postoperatively\n* Undergo evaluation for postoperative complications",[29,64],[300,606,607,608,609],"manual flexible ureteroscopy","fURS","ILY robot","robotic","2025-05-21",{"date":612,"type":43},"2025-05-30",{"date":614,"type":43},"2025-05-01",{"date":616,"type":23},"2027-08",{"name":618,"class":50},"Albert El Hajj",{"id":620,"slug":621,"hasResults":12,"nctId":622,"briefTitle":623,"officialTitle":624,"acronym":4,"eligibilityCriteria":625,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":86,"enrollmentInfo":626,"targetDuration":4,"studyType":24,"phases":627,"briefSummary":628,"conditions":629,"keywords":630,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":636,"lastUpdatePostDateStruct":637,"startDateStruct":639,"completionDateStruct":641,"leadSponsor":643,"locationsCount":51},"100585119","steerable-vs-conventional-fans-for-2cm-lower-pole-stone-treatment-sculpt-trial-100585119","NCT06898216","Steerable vs Conventional FANS for \u003C2cm Lower Pole Stone Treatment: SCULPT Trial","Flexible Ureteroscopy With Steerable Versus Conventional Flexible and Navigable Suction Ureteral Access Sheath (FANS) Utility in Less Than 2cm Lower Pole Stones Treatment: a Multicenter, Randomized Superiority Trial (SCULPT Trial)","Inclusion Criteria:\n\n* Adults aged 18-75 years\n* Diagnosed with a single lower pole renal stone ≤2 cm by CT\n* American Society of Anesthesiology (ASA) score of 1-3\n* Ability to provide written informed consent\n* Willingness and ability to comply with trial procedures and follow-up\n\nExclusion Criteria:\n\n* Patients with urinary tract anatomical abnormalities (e.g., horseshoe kidney, ileal conduit)\n* Untreated urinary tract infection\n* Presence of multiple stones or stones located outside the lower pole\n* Absolute contraindications to flexible ureteroscopy\n* Inability to understand or complete trial documentation",{"count":412,"type":23},[26],"This multicenter, randomized, controlled superiority trial (the SCULPT trial) aims to compare the efficacy and safety of a novel steerable flexible and navigable suction ureteral access sheath (FANS) versus the conventional FANS in the treatment of lower pole renal stones ≤2 cm. Lower pole stones are particularly challenging due to the narrow infundibular-pelvic anatomy that limits the maneuverability of standard FANS. The steerable FANS incorporates an active deflection mechanism that allows for independent control, potentially improving the success rate of accessing the lower pole calyx, performing laser lithotripsy, and aspirating stone fragments without additional adjuncts.\n\nA total of 400 patients from 20 high-volume urological centers in China (approximately 20 patients per center) will be randomized in a 1:1 ratio to receive either steerable FANS or conventional FANS during flexible ureteroscopy. Primary outcome measures include the success rate of FANS navigation into the lower pole calyx as evidenced by direct stone visualization, effective laser lithotripsy, and successful stone aspiration. Secondary outcomes will assess immediate and 1-month stone-free rates, operative time, complication rates, instrument durability, and improvements in quality of life. This study is expected to provide critical evidence to guide clinical decision-making and potentially improve treatment efficiency for challenging lower pole renal stones.",[29],[631,632,633,634,635],"flexible ureteroscopy","flexible and navigable suction ureteral access sheath","FANS","lower pole","renal stones","2025-03-20",{"date":638,"type":43},"2025-03-27",{"date":640,"type":43},"2025-03-16",{"date":642,"type":23},"2026-03-01",{"name":49,"class":50}]