[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"knee-arthritis-osteoarthritis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:knee-arthritis-osteoarthritis":61},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,47,71,94,116,150,178,207,232,259,290,309,332],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100644881","daily-knee-sleeve-use-versus-no-use-in-older-adults-with-chronic-knee-pain-100644881",false,"NCT07674901","Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain","A Superiority Randomized Controlled Trial of Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain","Inclusion Criteria:\n\n1. Aged 50-64 years at the time of his\u002Fher baseline eligibility screening\n2. Unilateral or bilateral chronic (≥ 3 months) knee pain\n3. Knee circumference between 12\" (30 cm) and 22\" (56 cm) measured over center of kneecap; or if a larger size is needed, thigh circumference up to 28\" (71 cm) measured at 4\" ABOVE center of knee cap per manufacturers' size specifications for the knee sleeves used in the intervention\n4. English-speaking and able to provide informed consent for study participation\n\nExclusion Criteria:\n\n1. History of knee replacement surgery in the painful\u002Faffected knee(s)\n2. Knee replacement surgery or arthroscopic procedure scheduled or anticipated in the affected knee(s) within 1 year after study eligibility screening\n3. Self-reported history or medical documentation of rheumatoid arthritis, psoriatic arthritis or other inflammatory arthritis in any joint; peripheral arterial disease or other vascular or circulatory disorder; blood clotting disorder; bleeding disorder or self-reported easy bruising; current treatment with an anticoagulant or antiplatelet agent; immobility; nonambulatory status; knee ligament tear or rupture; or lower extremity fracture requiring internal or external fixation within 1 year before study eligibility screening\n4. History of unprovoked falls\n5. Current use of a rigid or hinged knee brace made of metal, plastic or fiberglass, or prescription for a knee brace for the affected knee(s)\n6. Previous use of a knee sleeve\u002Ffabric knee support on the affected knee(s) for over 6 months cumulative time\n7. Inability to pull on or remove elasticized knee sleeve from affected knee(s)\n8. Kellgren-Lawrence (KL) grade 4 on a baseline standing\u002Fweightbearing A\u002FP knee radiograph of the affected knee(s) is excluded because it is the highest KL grade, so a primary outcome event (transition to a higher grade) is impossible.\n9. Moderate to severe knee effusion on baseline radiographs of the painful knee(s) is excluded due to the potential risk of harm and discomfort from the compressive effect of a knee sleeve. Individuals with moderate to severe knee effusion during the first screening assessment who are otherwise eligible will be invited to have a repeat A\u002FP knee x-ray 2 months later to reassess radiological eligibility. If the effusion is mild or has resolved by that time, the individual will be invited to enroll in the study.\n10. Pregnancy (because of x-ray exposure)\n11. Cannot attend a 5-year study assessment for follow-up knee radiographs\n12. Investigator discretion","ALL","50 Years","64 Years",{"count":20,"type":21},235,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this superiority randomized controlled trial is to evaluate the effect of daily knee sleeve use on 5-year radiographic knee osteoarthritis progression and knee-related symptoms in older adults with chronic knee pain. The investigators will recruit 235 individuals aged 50-64 years at baseline with chronic (≥ 3 months) knee pain, randomized to daily use of an elasticized fabric knee sleeve versus no knee sleeve use. Participants will have knee radiographs at baseline and year 5 and will complete a survey including Knee injury and Osteoarthritis Outcome Score (KOOS) subscales for pain, knee function and quality of life at 3 months and annually. A prespecified interim analysis of the 1-year KOOS subscore data will be performed.",[27],"Knee Arthritis, Osteoarthritis",[29,30,31,32,33],"Osteoarthritis","Arthritis","Joint, Knee","Osteoarthritis, Knee","Pain, Musculoskeletal","NOT_YET_RECRUITING","2026-06-30",{"date":37,"type":38},"2026-07-01","ACTUAL",{"date":40,"type":21},"2026-09",{"date":42,"type":21},"2032-09",{"name":44,"class":45},"Margaret L Gourlay, MD, MPH","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100644287","laser-vs-lontophoresis-in-koa-100644287","NCT07666061","Laser vs Lontophoresis in KOA","Effectiveness of Laser Therapy Versus Lontophoresis in the Management of Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* \\* Age 45-65 years.\n\n  * Diagnosed primary knee osteoarthritis (Grade I-II).\n  * Both genders.\n  * Ability to follow treatment protocol.\n\nExclusion Criteria:\n\n* \\* Previous knee surgery.\n\n  * Intra-articular injections within last 6 months.\n  * Pacemaker.\n  * Skin lesions at treatment area.\n  * Severe neurological or cardiovascular disorders.","45 Years","65 Years",{"count":57,"type":21},66,[24],"This randomized controlled trial aims to compare the effectiveness of laser therapy and iontophoresis in patients with knee osteoarthritis. The study will evaluate pain reduction, functional improvement, and knee joint mobility following",[61],"Knee Arthritis Osteoarthritis","2026-06-18",{"date":64,"type":38},"2026-06-24",{"date":66,"type":21},"2026-08-01",{"date":68,"type":21},"2027-04-01",{"name":70,"class":45},"Kafrelsheikh University",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":46},"100641918","perturbation-based-balance-training-versus-progressive-neuromuscular-training-as-an-adjunct-to-conventional-physiotherapy-for-pain-reduction-and-functional-improvement-in-knee-osteoarthritis-100641918","NCT07653841","Perturbation Based Balance Training Versus Progressive Neuromuscular Training as an Adjunct to Conventional Physiotherapy for Pain Reduction and Functional Improvement in Knee Osteoarthritis","Inclusion Criteria:\n\nMale and female, aged between 40-70 years Diagnosed with knee osteoarthritis Grades I-III based on the Kellgren-Lawrence classification Chronic knee pain for ≥3 months Ability to walk independently\n\nExclusion Criteria:\n\nGrade IV osteoarthritis Previous knee surgery or joint replacement Rheumatoid arthritis or inflammatory joint disease Recent intra-articular injection (\\\u003C6 months) Severe systemic illness, Neurological disorders and Vestibular disorders","40 Years","70 Years",{"count":80,"type":21},60,[24],"This is an RCT aims to explore Perturbation-Based Balance Training versus Progressive Neuromuscular Training as an Adjunct to Conventional Physiotherapy for Pain Reduction and Functional Improvement in Knee Osteoarthritis.",[61,27],"RECRUITING","2026-06-16",{"date":87,"type":38},"2026-06-17",{"date":89,"type":21},"2026-05-18",{"date":91,"type":21},"2026-09-20",{"name":93,"class":45},"Ibadat International University, Islamabad",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":101,"targetDuration":4,"studyType":22,"phases":103,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":46},"100638081","effects-of-mobilized-balance-platform-exercises-on-balance-parameters-in-patients-with-knee-osteoarthritis-100638081","NCT07575425","Effects of Mobilized Balance Platform Exercises on Balance Parameters in Patients With Knee Osteoarthritis","Effects of Mobilized Balance Platform Exercises on Balance Parameters, Functional Status, and Pain in Patients With Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged between 45 and 65 years\n* Diagnosis of knee osteoarthritis classified as Kellgren-Lawrence grade 2 or 3\n* Willingness to participate voluntarily in the study\n\nExclusion Criteria:\n\n* Presence of orthopedic knee implants\n* Kellgren-Lawrence grade 1 or grade 4 knee osteoarthritis\n* Sensory impairment\n* Diagnosis of malignancy\n* Unhealed fractures\n* Circulatory disorders\n* Infection around the knee joint\n* Severe hearing loss or visual impairment\n* Cognitive impairment\n* Uncontrolled hypertension or diabetes mellitus\n* Vestibular disorders causing balance problems, such as vertigo\n* Use of walking assistive devices such as canes or walkers",{"count":102,"type":21},36,[24],"This prospective single-blind randomized controlled study aims to investigate the effects of mobilized balance platform exercises on balance parameters, pain, functional status, fear of falling, and kinesiophobia in patients with knee osteoarthritis. A total of 36 patients diagnosed with knee osteoarthritis will be recruited from the outpatient clinic of Gaziler Physical Medicine and Rehabilitation Training and Research Hospital.\n\nParticipants will be randomly assigned to one of two groups. The control group will receive conventional physical therapy including transcutaneous electrical nerve stimulation (TENS) and a home exercise program consisting of knee strengthening, balance, range of motion, proprioceptive, and stretching exercises. The intervention group will receive the same conventional treatment in addition to mobilized balance platform exercises using the Huber 360 system.\n\nPain severity, functional status, balance parameters, fear of falling, and kinesiophobia will be evaluated before and after treatment by an assessor blinded to treatment allocation.",[106,27],"Osteearthritis","2026-05-03",{"date":109,"type":38},"2026-05-08",{"date":111,"type":38},"2026-05-04",{"date":113,"type":21},"2026-10-30",{"name":115,"class":45},"Gaziler Physical Medicine and Rehabilitation Education and Research Hospital",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":123,"minAge":124,"maxAge":55,"enrollmentInfo":125,"targetDuration":127,"studyType":128,"phases":4,"briefSummary":129,"conditions":130,"keywords":138,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":143,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":46},"100639251","the-effect-of-lipedema-on-knee-osteoarthritis-100639251","NCT07575555","The Effect of Lipedema on Knee Osteoarthritis","The Effect of Lipedema on Knee Osteoarthritis: A Cross-Sectional Analysis of Clinical Symptoms and Ultrasonographic Findings","Inclusion Criteria:\n\nAll participants (Group 1 + Group 2)\n\n* Women aged 30-65\n* With a clinical and radiological diagnosis of knee osteoarthritis\n* Who agreed to participate in the study\n\nGroup 1 (knee osteoarthritis with lipedema):\n\n* Patients who meet the Wold criteria for a clinical diagnosis of lipedema\n* An increase in subcutaneous fat thickness confirmed by ultrasound\n\nGroup 2 (knee osteoarthritis without lipedema):\n\n* No diagnosis of lipedema\n* Exclusion of lymphedema and venous diseases\n\nExclusion Criteria:\n\n* Inflammatory arthritis\n* History of knee surgery\n* Intra-articular injection within the past 6 months\n* Acute trauma\n* Systemic connective tissue disease\n* Severe venous insufficiency or lymphedema\n* History of malignancy\n* Use of gabapentinoids\u002FSNRIs\u002FSSRIs due to fibromyalgia or psychiatric illness\n* Severe cognitive impairment or communication problems that would prevent participation in the study\n* Pregnancy\n* Participants who were informed about the study and refused to participate","FEMALE","30 Years",{"count":126,"type":21},76,"1 Day","OBSERVATIONAL","This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context. Although the relationship between obesity and osteoarthritis has been extensively studied in the literature, the effect of specific adipose tissue pathologies, such as lipedema, on osteoarthritis has not been sufficiently investigated. This study aims to demonstrate the independent effect of lipedema on osteoarthritis, evaluate clinical and ultrasonographic parameters together, and contribute to early diagnosis and targeted rehabilitation strategies.",[131,132,133,134,61,135,136,137],"Lipedema","Knee Osteoarthritis","Knee Acute and Chronic Pain","Knee","Knee Arthropathy","Knee Cartilage Defects","Knee Cartilage Lesions",[139,140,141,142],"lipedema","knee osteoarthritis","knee joint","knee",{"date":109,"type":38},{"date":145,"type":21},"2026-07-15",{"date":147,"type":21},"2027-08-15",{"name":149,"class":45},"Izmir Democracy University",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":158,"sex":16,"minAge":124,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":22,"phases":162,"briefSummary":163,"conditions":164,"keywords":165,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":46},"100635327","knee-osteoarthritis-rehab-high-intensity-laser-vs-classical-modalities-100635327","NCT07551245","Knee Osteoarthritis Rehab: High-Intensity Laser vs Classical Modalities","Rehabilitation of Knee Osteoarthritis by High Intensity Laser Therapy vs Classical Modalities","HILT-CM (KOA)","Inclusion Criteria:\n\n* Diagnosis of Knee Osteoarthritis: Patients must have a clinical and radiographic diagnosis of knee OA according to the American College of Rheumatology (ACR) criteria, including evidence of joint space narrowing, osteophyte formation, and other degenerative changes observed on X-rays or MRI.\n\nAge: Adults aged between 40 and 75 years. Willingness to Participate: Participants must provide informed consent and be willing to adhere to the study protocol, including attending all treatment sessions and follow-up assessments.\n\nKellgren-Lawrence Grade: Patients with knee OA grades 1-3 (mild to moderate OA).\n\nExclusion Criteria:\n\n* Contraindications to Laser Therapy:\n\nActive malignancy History of epilepsy Photosensitivity disorders Active infection in the treatment area\n\nSurgical History:\n\nPatients who have undergone knee surgery within the past 6 months Scheduled surgery during the study period\n\nAdvanced Disease:\n\nKellgren-Lawrence Grade 4 (severe OA) where surgical intervention is indicated\n\nPregnancy or Lactation:\n\nPregnant or lactating women\n\nSevere Comorbidities:\n\nUncontrolled diabetes Severe cardiovascular disease Neurological disorders that might interfere with participation or affect treatment outcomes",true,"60 Years",{"count":161,"type":21},100,[24],"This study aims to compare the effectiveness and safety of High-Intensity Laser Therapy (HILT) with conventional physical therapy treatments in patients with knee osteoarthritis. Knee osteoarthritis is a common condition, especially in older adults, causing pain, stiffness, reduced movement, and difficulty performing daily activities. Current treatments focus on reducing pain and improving joint function.\n\nIn this study, 100 patients with knee osteoarthritis will be divided into two groups. One group will receive HILT combined with therapeutic exercises, while the other group will receive conventional physical therapy modalities along with the same exercises. The treatment outcomes will be evaluated over time.\n\nThe main outcomes include pain reduction (measured by pain scales such as WOMAC and VAS), improvement in joint function, and structural changes in the knee assessed by MRI. In addition, laboratory tests will be used to measure inflammation, cartilage health markers, and oxidative stress before and after treatment.\n\nThe goal is to determine whether HILT provides better pain relief, improves joint function, and is safe compared to standard therapy. The results may help improve rehabilitation strategies for patients with knee osteoarthritis.",[61],[166,167,168],"LASER","knee OA","classical modalities","2026-04-19",{"date":171,"type":38},"2026-04-24",{"date":173,"type":38},"2026-04-20",{"date":175,"type":21},"2027-01-20",{"name":177,"class":45},"Erbil Polytechnic University",{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":16,"minAge":184,"maxAge":4,"enrollmentInfo":185,"targetDuration":4,"studyType":22,"phases":187,"briefSummary":190,"conditions":191,"keywords":192,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":46},"100634678","phase-2-an-open-label-double-treatment-group-study-to-evaluate-the-efficacy-and-safety-of-human-allogeneic-bone-marrow--derived-mesenchymal-stromal-cell-product-stromaforte-compared-with-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis-100634678","NCT07542808","An Open-Label, Double-Treatment Group Study to Evaluate the Efficacy and Safety of Human Allogeneic Bone-Marrow- Derived Mesenchymal Stromal Cell Product StromaForte Compared With Hyaluronic Acid for the Treatment of Knee Osteoarthritis","Inclusion Criteria:\n\n* Willing and able to provide written informed consent and comply with all procedures required by the protocol.\n* Aged ≥ 18 years at the time of signing the informed consent form.\n* Diagnosed with knee osteoarthritis (OA) based on the criteria established by the American College of Rheumatology, confirmed through radiological images no older than three months.\n* Grade I to IV osteoarthritis on the Kellgren-Lawrence radiological classification scale.\n* Joint pain during activity as assessed by the Visual Analogue Scale (VAS) of ≥ 40 at the time of screening\n* Body Mass Index (BMI) between ≥ 18.5 to ≤ 35.0 kg\u002Fm2\n\nExclusion Criteria:\n\n* Unwilling or unable to perform any of the assessments required by the protocol.\n* Mechanically unstable knee due to the presence of a complete anterior cruciate ligament, posterior cruciate ligament, medial collateral ligament and\u002For posterolateral corner tear.\n* Varus or valgus malalignment \\>5 degrees as measured by 4-foot standing antero-posterior radiographs.\n* History of subtotal medial or lateral meniscectomy performed less than 9 months ago.\n* History of septic arthritis in the targeted knee.\n* History of infectious or inflammatory joint disorders or suspected infective or inflammatory joint disease.\n* Systemic or intra-articular injection of corticosteroids in any joint within 3 months before screening.\n* Immunosuppression due to illness or medication including but not limited to high dose corticosteroids, calcineurin inhibitors, anti-TNF, anti-IL-6, anti-p40, biologics and prednisone and\u002For equivalent over 5 mg\u002Fday.\n* Planned orthopaedic surgery on lower limbs within the next 12 months\n* Active or suspected infection.\n* History of malignancy in the past 2.5 years, except in-situ cancers treated by local excision with curative intent.\n* Severe bleeding diathesis.\n* Participation in another clinical trial including treatment with a different investigational product within 30 days prior to inclusion in this study.\n* Pregnancy or breastfeeding.\n* Unwilling or for medical reason not recommended to pause anticoagulant medications prior to procedure, as judged by prescribing doctor.\n* Known diagnosis of HIV-1, HIV-2, Hepatitis A, Hepatitis B, Hepatitis C, HTLV-I\u002FII, or Syphilis, or other acute or chronic infectious disease.\n* Pulmonary embolism, deep vein thrombosis or other serious embolic disease within the past 4 months.\n* Known allergies or hypersensitivity to DMSO, human serum albumin, heparin or PlasmaLyte.\n* History or current evidence of any condition, therapy, laboratory abn ormality, or other circumstance that might confound the results of the study or interfere with the study participant's participation for the full duration of the study.\n* Cognitive or language barriers that prohibit obtaining informed consent, questionnaires or any study elements.\n* Recipient of any stem cell therapy within the previous 12 months","18 Years",{"count":186,"type":21},140,[188,189],"PHASE2","PHASE3","StromaForte injection for knee OA",[61],[193,194,195,196],"Cellcolabs","Knee OA","Mesenchymal stem cells","Cell therapy","2026-04-15",{"date":199,"type":38},"2026-04-21",{"date":201,"type":21},"2026-04-27",{"date":203,"type":21},"2027-09-27",{"name":205,"class":206},"Cellcolabs Clinical SPV Limited","INDUSTRY",{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":215,"enrollmentInfo":216,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":217,"conditions":218,"keywords":219,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":4},"100632740","condylar-offset-and-outcomes-in-primary-total-knee-arthroplasty-100632740","NCT07517614","Condylar Offset and Outcomes in Primary Total Knee Arthroplasty","Prospective Evaluation of Posterior and Anterior Condylar Offset and Their Impact on Functional Outcomes in Primary Total Knee Arthroplasty","OFFSET-TKA","Inclusion Criteria:\n\n* diagnosis of primary knee osteoarthiritis\n* indication of knee arthroplasty\n* 50-85 years\n* ability t oprovide informed consent and comply with follow up\n\nExclusion Criteria:\n\n* revision knee arthroplasty\n* inflammatory arthritis\n* severe corona deformity (\\>20 varus\u002Fvalgus)\n* previous knee surgery or fracture","85 Years",{"count":161,"type":21},"This prospective cohort study aims to evaluate the effect of posterior condylar offset (PCO) and anterior condylar offset (ACO) changes on functional outcomes after primary total knee arthroplasty (TKA). Standardized imaging and clinical assessment protocols will be used to determine optimal PCO and ACO ranges associated with improved postoperative range of motion, patient-reported outcomes, and reduced anterior knee symptoms.",[61],[220,221,222],"knee osteoarthiritis","anterior condylar offset","posterior condylar offset","2026-04-03",{"date":225,"type":38},"2026-04-08",{"date":227,"type":21},"2026-05",{"date":229,"type":21},"2027-07",{"name":231,"class":45},"SB Istanbul Education and Research Hospital",{"id":233,"slug":234,"hasResults":11,"nctId":235,"briefTitle":236,"officialTitle":236,"acronym":237,"eligibilityCriteria":238,"healthyVolunteers":11,"sex":16,"minAge":77,"maxAge":239,"enrollmentInfo":240,"targetDuration":4,"studyType":22,"phases":241,"briefSummary":242,"conditions":243,"keywords":246,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":257,"locationsCount":4},"100629327","comparison-of-platelet-rich-plasma-and-activated-cytokine-rich-serum-injection-treatments-in-patients-with-knee-osteoarthritis-koa-prp-acs-100629327","NCT07473232","Comparison of Platelet-rich Plasma and Activated Cytokine-rich Serum Injection Treatments in Patients With Knee Osteoarthritis. (KOA PRP ACS)","KOA PRP ACS","Inclusion Criteria:\n\n1. Diagnosis of knee osteoarthritis according to ACR criteria at least 6 months ago.\n2. Being between grade 1-2 according to the Kellgren-Lawrence radiological classification.\n3. Not having had PRP injection in the last year.\n4. Knee pain ≥ 5 according to the visual pain scale.\n\nExclusion Criteria:\n\n1. Those with significant neurological or cardiovascular disorders.\n2. Those with active thrombovascular disease.\n3. Those with joint or skin infections.\n4. Those who have recently had an infectious disease.\n5. Those infected with Hepatitis B, C, and HIV.\n6. Those who have received intra-articular knee injections (hyaluronic acid, PRP, corticosteroids, and others) within the last year.\n7. Those who use oral corticosteroids.\n8. Those who have used NSAIDs within the last week.\n9. Those who have used anti-platelet or anti-aggregant drugs within the last week.\n10. Those with coagulation disorders.\n11. Those with hemoglobin \\\u003C10 g\u002Fdl and platelet count \\\u003C100,000\n12. Those with cancer.\n13. Pregnant or breastfeeding women, drug addicts.\n14. Those scheduled for knee surgery or arthroscopy, or those who have undergone knee surgery or arthroscopy.\n15. Those with diseases causing secondary osteoarthritis:\n\n    1. post-traumatic,\n    2. congenital or developmental diseases\n\n       1. Local diseases (leg length discrepancy, varus, valgus deformities, hypermobility syndromes, scoliosis)\n       2. Generalized diseases (Bone dysplasias, Metabolic disorders (hemochromatosis, ochronosis, Gaucher disease, hemoglobinopathy, Ehlers-Danlos disease))\n    3. Calcium storage diseases (calcium pyrophosphate storage disease, etc.)\n    4. Other bone and joint diseases (avascular necrosis, rheumatoid arthritis, gouty arthritis, septic arthritis, Paget's disease, osteoporosis, osteochondritis)\n    5. Other diseases\n\n       1. Endocrine diseases (Diabetes mellitus, acromegaly, hypothyroidism, hyperthyroidism)\n       2. Neuropathic arthropathy (Charcot joint)\n       3. Other (Frost, Kashin-Beck disease, Caisson disease) -","80 Years",{"count":80,"type":21},[24],"The effects of single dose injection of platelet rich plasma or conditioned serum in the knee joint in patients with knee osteoarthritis will be compared",[61,244,245],"Platelet Rich Plasma Injection","Conditioned Serum",[140,247,248,249,250],"platelet rich plasma injection","conditioned serum injection","inflammation","cartilage","2026-03-16",{"date":253,"type":38},"2026-03-19",{"date":255,"type":21},"2026-04-01",{"date":35,"type":21},{"name":258,"class":45},"Pamukkale University",{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":16,"minAge":184,"maxAge":4,"enrollmentInfo":267,"targetDuration":4,"studyType":22,"phases":268,"briefSummary":269,"conditions":270,"keywords":276,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":46},"100625655","cryoneurolysis-prior-to-total-knee-arthroplasty-cryo-tka-trial-100625655","NCT07425457","Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)","Association of Pre-operative Genicular Nerves Cryoneurolysis With Improved Pain and Function in Patients Undergoing Total Knee Arthroplasty","CRYO-TKA","Inclusion Criteria:\n\n* Adults ≥18 years undergoing primary TKA for osteoarthritis.\n* Cognitively normal and able to self-assess pain and function.\n* Provide written informed consent.\n\nExclusion Criteria:\n\n* Cancer-related knee pain.\n* Neurological, psychiatric, or medical conditions interfering with assessment.\n* Chronic opioid users.",{"count":161,"type":21},[24],"Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.",[271,272,61,273,274,275],"Arthroplasty","Replacement Material","Knee Arthroplasty, Total","Genicular Nerves","Chronic Pain",[277,278,279,280],"Cryoneurolysis","Interventional Radiology","Pain Management","Post-operative recovery","2026-02-19",{"date":283,"type":38},"2026-02-20",{"date":285,"type":38},"2026-01-02",{"date":287,"type":21},"2028-03-31",{"name":289,"class":45},"Attikon Hospital",{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":296,"eligibilityCriteria":297,"healthyVolunteers":158,"sex":16,"minAge":77,"maxAge":78,"enrollmentInfo":298,"targetDuration":4,"studyType":22,"phases":299,"briefSummary":300,"conditions":301,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":302,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":46},"100625570","knee-osteoarthritis-rehabilitation-through-rotational-inertia-100625570","NCT07424352","Knee Osteoarthritis Rehabilitation Through Rotational Inertia","Exploring the Benefits of Eccentric Training for Aging Adults With Knee Osteoarthritis","KORRI","Inclusion Criteria Osteoarthritis (OA) Group:\n\n* Aged 40-70 years\n* Radiographically confirmed knee OA (Kellgren-Lawrence \\[KL\\] Grade 2 or 3)\n* Able to walk independently (assistive devices permitted)\n\nInclusion Criteria Healthy Control Group:\n\n* Aged 40-70 years\n* No radiographic evidence of knee OA (KL Grade 0 or 1)\n* No frequent knee pain\n* No history of:\n* Knee surgery (e.g., ACL reconstruction, meniscectomy, patellar realignment)\n* Significant knee injury (e.g., ligament tears, fractures, dislocations)\n* Diagnosed knee conditions (e.g., patellofemoral pain syndrome, bursitis)\n\nExclusion Criteria:\n\n* Uncontrolled hypertension or other cardiovascular disease\n* A musculoskeletal condition preventing physical testing\n* Neurological muscle weakness (e.g., stroke, spinal cord injury)\n* BMI \\>34.9 kg\u002Fm²\n* Recent hospitalization (past 3 months)",{"count":80,"type":21},[24],"This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength, and coordination more effectively than conventional methods.\n\nThe study's central idea is that better muscle quality and improved coordination will lead to smoother, safer stair movement and reduce the risk of falls. Advanced tools such as ultrasound imaging and motion analysis will be used to measure muscle health and movement patterns in detail.\n\nThe hypothesis is that individuals with knee osteoarthritis have poorer muscle quality and less coordinated stair-stepping compared to healthy adults, and that performing eccentric overload training will enhance muscle quality, improve movement coordination, and make stair navigation safer and more efficient.",[27],{"date":283,"type":38},{"date":304,"type":38},"2025-08-20",{"date":306,"type":21},"2029-05-31",{"name":308,"class":45},"University of Colorado, Denver",{"id":310,"slug":311,"hasResults":11,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":4,"eligibilityCriteria":315,"healthyVolunteers":11,"sex":16,"minAge":77,"maxAge":159,"enrollmentInfo":316,"targetDuration":4,"studyType":22,"phases":318,"briefSummary":319,"conditions":320,"keywords":321,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":46},"100623962","effects-of-9-points-electrical-dry-needling-in-knee-osteoarthritis-100623962","NCT07403448","Effects of 9 Points Electrical Dry Needling in Knee Osteoarthritis","Effects of 9 Points Electrical Dry Needling on Pain, Range of Motion, Function and Quality of Life in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* participants age group from 40-60 years\n* Both male and female genders\n* Knee osteoarthritis (OA) confirmed by radiographic evidence (Kellgren- Lawrence grade 3).\n* Numerical Pain Rating Scale (NPRS) ≥ 4\u002F10.\n* Able to stand and bear weight on affected knee.\n* WOMAC score \\> 25 moderate level of difficulty performing ADL\n* Participant with restricted range of motion\n* Pain while walking and ascending stairs\n* Patients volunteered to participate in the study and signed informed consent\n\nExclusion Criteria:\n\n* Mild to severe knee osteoarthritis (Kellgren-Lawrence grade 2 or 4).\n* Recent knee surgery or injection (\\\u003C6 months).\n* Knee instability and ligamentous injury.\n* Pregnancy and breastfeeding.\n* Patient with needle phobia and with history of abnormal reaction to needles.\n* Diagnosed psychological disorders\n* Anticoagulant patient, tumors and hematomas.\n* All acute emergencies and acute systematic fevers.\n* Pacemakers and implantable cardioverter defibrillators",{"count":317,"type":21},44,[24],"The study will be conducted to compare effects of 9 points electrical dry needling along with standard physical therapy and standard physical therapy alone in knee osteoarthritis patients.",[61],[322],"Arthritis, knee pain, Electrical dry needling, Grade 3 KOA, Functional limitations","2026-02-04",{"date":325,"type":38},"2026-02-11",{"date":327,"type":21},"2026-01-25",{"date":329,"type":21},"2026-07-25",{"name":331,"class":45},"Riphah International University",{"id":333,"slug":334,"hasResults":11,"nctId":335,"briefTitle":336,"officialTitle":336,"acronym":4,"eligibilityCriteria":337,"healthyVolunteers":11,"sex":16,"minAge":184,"maxAge":78,"enrollmentInfo":338,"targetDuration":4,"studyType":22,"phases":340,"briefSummary":342,"conditions":343,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":349,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":46},"100599804","phase-4-the-perioperative-outcome-of-epinephrine-infusion-and-tranexamic-acid-in-knee-arthroplasty-surgery-100599804","NCT07089251","The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery","Inclusion Criteria:\n\n* Patients undergoing knee joint arthroplasty.\n* Saudi and Non-Saudi Patient.\n* Patients who have Complete medical record.\n\nExclusion Criteria:\n\n* End stage renal disease\n* Liver cirrhosis\n* Coagulopathy\n* Pre-operative Hgb \\\u003C10 5.\n* History of cerebrovascular accident or myocardial infarction in past 12 months.\n* History of Heart failure.\n* History of arrhythmia.\n* History of pheochromocytoma, thyrotoxicosis and glaucoma.\n* Pregnancy or breast feeding\n* History of Deep venous thrombosis or pulmonary embolism\n* Allergy to epinephrine or tranexamic acid",{"count":339,"type":21},80,[341],"PHASE4","The aim of this clinical trial is to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative blood loss, thromboembolic complications, and hospitalization duration in patients undergoing knee joint arthroplasty.\n\nAlso aim to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative thromboembolic complications, and hospitalization duration",[273,27,344,345,346,347],"Total Knee Anthroplasty","Blood Loss","Tranexamic Acid Use","Epinephrine","2025-07-21",{"date":350,"type":38},"2025-07-28",{"date":352,"type":38},"2025-07-15",{"date":354,"type":21},"2027-06-24",{"name":356,"class":45},"King Abdullah International Medical Research Center"]