[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"knee-arthropathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:knee-arthropathy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,20,0,[8,43,80,102,125,146,171,196,219,243,264,286,312,341,374,400,426,448,472,498],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100539044","improving-total-knee-arthroplasty-dissatisfaction-through-a-personalized-approach-focusing-on-proms-phenotypes-100539044",false,"NCT06298721","Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes","Improving Total Knee Arthroplasty Dissatisfaction at 1-year Through a Personalized Approach Focusing on PROMs Phenotypes: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Adult subject (Age \\>18 and \\\u003C 80 years of age)\n2. The subject is proficient in the English language\n3. The patient is voluntarily prepared to sign the 'Informed Consent Form'\n4. The patient is scheduled for a unilateral primary TKA\n5. TKA PROMs Phenotypes with higher risk of dissatisfaction\n6. Patient is willing and able to complete the protocol required follow-up\n\nExclusion Criteria:\n\n1. Patient requires simultaneous or staged bilateral knee replacements, staged \\\u003C90 days apart\n2. Patients undergoing revision TKA\n3. Inflammatory arthritis\n4. History of infection in the joint undergoing TKA\n5. Patient is considered a member of a protected population (e.g., prisoner, mentally incompetent, etc.)","ALL","18 Years","80 Years",{"count":20,"type":21},300,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is a randomized controlled trial to assess whether the implementation of a TKA Personalized Outcome Prediction Tool to set expectation, in addition to targeted interventions to address patients with poor baseline mental health and poor physical function, improves satisfaction at 1-year (when compared to standard of care).",[27,28,29],"Knee Osteoarthritis","Knee Arthropathy","Surgery","RECRUITING","2026-06-09",{"date":33,"type":34},"2026-06-11","ACTUAL",{"date":36,"type":34},"2024-03-12",{"date":38,"type":21},"2027-03-01",{"name":40,"class":41},"The Cleveland Clinic","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":55,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":42},"100639251","the-effect-of-lipedema-on-knee-osteoarthritis-100639251","NCT07575555","The Effect of Lipedema on Knee Osteoarthritis","The Effect of Lipedema on Knee Osteoarthritis: A Cross-Sectional Analysis of Clinical Symptoms and Ultrasonographic Findings","Inclusion Criteria:\n\nAll participants (Group 1 + Group 2)\n\n* Women aged 30-65\n* With a clinical and radiological diagnosis of knee osteoarthritis\n* Who agreed to participate in the study\n\nGroup 1 (knee osteoarthritis with lipedema):\n\n* Patients who meet the Wold criteria for a clinical diagnosis of lipedema\n* An increase in subcutaneous fat thickness confirmed by ultrasound\n\nGroup 2 (knee osteoarthritis without lipedema):\n\n* No diagnosis of lipedema\n* Exclusion of lymphedema and venous diseases\n\nExclusion Criteria:\n\n* Inflammatory arthritis\n* History of knee surgery\n* Intra-articular injection within the past 6 months\n* Acute trauma\n* Systemic connective tissue disease\n* Severe venous insufficiency or lymphedema\n* History of malignancy\n* Use of gabapentinoids\u002FSNRIs\u002FSSRIs due to fibromyalgia or psychiatric illness\n* Severe cognitive impairment or communication problems that would prevent participation in the study\n* Pregnancy\n* Participants who were informed about the study and refused to participate","FEMALE","30 Years","65 Years",{"count":54,"type":21},76,"1 Day","OBSERVATIONAL","This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context. Although the relationship between obesity and osteoarthritis has been extensively studied in the literature, the effect of specific adipose tissue pathologies, such as lipedema, on osteoarthritis has not been sufficiently investigated. This study aims to demonstrate the independent effect of lipedema on osteoarthritis, evaluate clinical and ultrasonographic parameters together, and contribute to early diagnosis and targeted rehabilitation strategies.",[59,27,60,61,62,28,63,64],"Lipedema","Knee Acute and Chronic Pain","Knee","Knee Arthritis Osteoarthritis","Knee Cartilage Defects","Knee Cartilage Lesions",[66,67,68,69],"lipedema","knee osteoarthritis","knee joint","knee","NOT_YET_RECRUITING","2026-05-03",{"date":73,"type":34},"2026-05-08",{"date":75,"type":21},"2026-07-15",{"date":77,"type":21},"2027-08-15",{"name":79,"class":41},"Izmir Democracy University",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100588490","cryoneurolysis-in-patients-awaiting-total-hip-and-knee-arthroplasty-100588490","NCT06942078","Cryoneurolysis in Patients Awaiting Total Hip and Knee Arthroplasty","Cryoneurolysis as an Interim Pain Control Strategy in Patients Awaiting Total Hip and Knee Arthroplasty: a Prospective Observational Study","Inclusion Criteria:\n\n* Currently awaiting THA or TKA (have signed consent for surgery)\n* Osteoarthritis as a primary diagnosis for THA or TKA\n* Currently taking regular daily opioids for at least one month\n* No allergies to local aesthetics\n* Speaks and understands English\n* Over 18 years old\n* Lives within a 1-hour distance of the hospital where the study is taking place or willing to travel to the hospital for the interventions and follow up.\n\nExclusion Criteria:\n\n* If surgery is expected to be completed within 1 month of the intervention as this would limit our ability to evaluate the effectiveness of the cryoneurolysis procedure\n* Allergies to local anesthetics\n* Inability to communicate with investigators\n* Opioid use disorder\n* History of severe psychiatric or medical conditions which hinder effective communication\n* Living more than 1 hour away from the hospital where the study is taking place or unable to travel to the hospital for the interventions and follow up\n* Body mass Index (BMI) ≥40\n* Any contraindications specific to percutaneous cryoneurolysis such as history of bleeding diathesis, any active infections at the procedural site, cold urticaria, cryofibrinogenemia, cryoglobulinemia, paroxysmal cold hemoglobinuria, or Raynaud's disease (see Ilfeld \\& Finneran, 2020)\n* Use of therapeutic anticoagulation\n* Diagnosis of Non-Osteoarthritis as the cause for THA or TKA\n* Other chronic pain condition which patients may be taking opioids to control the pain (e.g. Fibromyalgia or Complex Regional Pain Syndrome)\n* Less than 50% reduction in pain with diagnostic blocks using 0.5% bupivacaine",{"count":88,"type":21},30,[24],"During the COVID-19 pandemic, there was a drastic increase in surgical wait times across Canada, notably for patients awaiting total knee and hip arthroplasty. Currently the average wait time for total hip arthroplasty (THA) in Alberta is 16 weeks with the 90th percentile of wait times being 47 weeks. The average wait for total knee arthroplasty (TKA) in Alberta is 20 weeks with the 90th percentile of wait times being 60 weeks. As the waitlist for these surgeries grows and with limited resources to increase the number of surgeries being performed, there is a critical need for strategies to manage the pain experienced by patients during these long waiting periods.\n\nMany patients awaiting surgery are placed onto long-term opioid therapy to manage their pain. There are, however, significant risks associated with the extended use of opioids for pain management, such as addiction, opioid abuse, increased risk of overdose, increased risk of fractures, and increased risk of adverse cardiac events. Recognizing these risks, different strategies need to be employed to attempt to minimize the opioid burden faced by those waiting for surgery. One potential strategy is to utilize regional anesthesia for analgesia rather than relying on opioids. Regional anesthesia with nerve blocks using local anesthetic has been used in the management of preoperative pain for patients awaiting surgery for hip fracture and has been shown to be effective in reducing pain, opioid use, and the risk of serious adverse effects. However, for patients with hip fractures, their surgery usually occurs within 36 hours due to significant risks which occur beyond that timeframe. For patients waiting for THA and TKA, the surgical wait time could be weeks to months. Providing daily nerve blocks or even weekly catheters for an individual waiting up to a year for surgery is not sustainable and carries significant risks with repeated injections. New regional anesthesia techniques lasting a longer period of time are needed.\n\nOne promising intervention is to utilize cryoneurolysis. Cryoneurolysis involves treating targeted nerves using extremely low temperatures. This disrupts nerve conduction and pain impulses. Importantly, connective tissue components of the nerve are left intact allowing for regeneration over time. Because of this, cryoneurolysis is a well-established treatment for chronic and acute pain due to its effectiveness and low risk safety profile. While cryoneurolysis is well-established in its use treating chronic and surgical pain, one limitation is that it is focused primarily on postoperative pain. Our study intends to primarily evaluate the efficacy of cryoneurolysis as a preoperative pain management intervention. Establishing the use of cryoneurolysis for preoperative pain will provide a valuable resource for reducing the pain patients experience while awaiting surgery, leading to decreased opioid use and improved overall well-being. The investigators will be recruiting 30 participants total (15 having TKA and 15 having THA) that will be given cryoneurolysis while waiting for their surgery.",[92,28],"Hip Arthropathy","2026-04-28",{"date":95,"type":34},"2026-05-04",{"date":97,"type":21},"2026-06-01",{"date":99,"type":21},"2028-12-31",{"name":101,"class":41},"University of Calgary",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":111,"conditions":112,"keywords":113,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":42},"100525306","post-market-clinical-follow-up-for-total-knee-arthroplasty-system-madison-100525306","NCT06120023","Post-Market Clinical Follow Up for Total Knee Arthroplasty System Madison","2022-07","Inclusion Criteria:\n\n* Male or female adults (≥ 18 years) covered by French social security system\n* Diagnosed with:\n\n  * Osteoarthritis (primary and secondary),\n  * Revision of a unicompartmental knee prosthesis.\n* Patient requiring a surgery and implantation of a Madison TKA (Total Knee Arthroplasty)\n* Patient physically and mentally able to comply with protocol, meet the follow-up visits as deemed by the investigator and fill in quality of life questionnaire.\n* Patient having signed a written informed consent\n\nExclusion Criteria:\n\n* Progressive, acute or chronic infection, local to the operative site or systemic that may affect the prosthetic joint,\n* Any loss of musculature or serious lesions of muscles, nerves and\u002For blood vessels deficiency, putting the affected limb at risk,\n* Lack of bone substance or inadequate bone quality on femoral or tibial surfaces, as it might compromise the stability of the prosthesis components,\n* Skeletal immaturity,\n* Pathologies that may compromise the functionality of the implant in any way (i.e. osteomyelitis, neuropathic joint),\n* Parameters incompatible with satisfactory long-term results (i.e. age, weight,\n* Neurological condition of the patient incompatible with the post-operative constraints associated with this type of intervention,\n* Known allergy to one of the implant components.\n* Severe obesity with or without comorbidities\n* Pregnant or nursing women,\n* Patients with a contraindication to radiography\n* Patients deprived of their liberty or hospitalised without their consent\n* Patients under legal protection (e.g. guardianship)",{"count":110,"type":21},1000,"MADISON Total Knee Prosthesis is intended to be used for total knee arthroplasty to reduce pain and restore joint mobility of the knee.\n\nClinical data for MADISON Total Knee Prosthesis available are not deemed sufficient to support performance and benefits claimed on the whole lifetime of the product.\n\nThus, in order to maintain compliance with the EU regulation (2017\u002F745) related to medical devices and following ISO 14\u002F155:2020, SERF has set up post-market clinical follow-up study (PMCF) to confirm safety and performance of Total Knee Arthroplasty system MADISON. This study is designed to cover the expected 15-years follow-up, to retrieve data according to implant feature (Posterior Stabilized or Ultra Congruent) or fixation method and to gather data related to the revision of partial knee prosthesis.\n\nThe primary objective of this study is to assess the clinical safety of MADISON total knee prostheses. The secondary objective is to evaluate the survival rates, the clinical performances and clinical benefits of MADISON total knee prosthesis.",[28],[114],"total knee prosthesis","2026-04-21",{"date":117,"type":34},"2026-04-22",{"date":119,"type":34},"2023-10-17",{"date":121,"type":21},"2040-12-31",{"name":123,"class":124},"Societe dEtude, de Recherche et de Fabrication","INDUSTRY",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":22,"phases":134,"briefSummary":135,"conditions":136,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":42},"100630927","extended-oral-tranexamic-acid-after-primary-total-knee-arthroplasty-100630927","NCT07494032","Extended Oral Tranexamic Acid After Primary Total Knee Arthroplasty","Extended Oral Tranexamic Acid After Primary Total Knee Arthroplasty: A Double-Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients are candidates for elective primary total knee arthroplasty.\n* Patients ≥18 years of age\n* Patients have been medically evaluated and scheduled for primary total knee arthroplasty.\n* Patients undergo primary total knee arthroplasty with spinal anesthesia\n* Patients receive 1g IV TXA prior to incision and 1g IV TXA at closure\n* Patients are prescribed aspirin 81mg twice a day for postoperative VTE prophylaxis\n\nExclusion Criteria:\n\n* Patients with an allergy to TXA\n* Patients taking a preoperative anticoagulant other than aspirin\n* Patients with a history of VTE\n* Patients with chronic kidney disease\n* Patients with active malignancy\n* Current use of combined hormonal contraception (pill, patch, or ring)\n* eGFR \\\u003C60 mL\u002Fmin\u002F1.73 m² or other clinically significant renal impairment\n* Use of Factor IX complex concentrates, anti-inhibitor coagulant concentrates, or all-trans retinoic acid (tretinoin)\n* Anticipated need for tissue plasminogen activator (tPA) during the 7-day dosing period\n* Individuals who are pregnant or breastfeeding, have a positive pre operative pregnancy test, or plan pregnancy during the 7 day dosing window. Women of childbearing potential must have a negative pre operative pregnancy test and use effective contraception through postoperative day . Individuals who are on hormonal contraceptives or hormone replacement therapies, with the exception of Progestin, are to be excluded.",{"count":133,"type":21},350,[24],"This study is a prospective double-blind randomized controlled trial to evaluate the effect of extended oral TXA after primary total TKA on short-term and mid-term postoperative outcomes, including function, pain, and postoperative complications over a 24-month period, with evaluations at 6 weeks, 3 months, 12 months, and 24 months. Each group of 175 patients will receive either extended oral TXA 1.95g daily or placebo for 7 days postoperatively. Function will be assessed by Knee Injury and Osteoarthritis Outcome Score, Joint Replacement (KOOS, JR) scores measured at all post operative time points as well as range of motion (ROM) (measured at all visits).",[28],"2026-03-20",{"date":139,"type":34},"2026-03-27",{"date":141,"type":21},"2026-05-01",{"date":143,"type":21},"2029-05-01",{"name":145,"class":41},"NYU Langone Health",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":16,"minAge":153,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":157,"briefSummary":158,"conditions":159,"keywords":160,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":42},"100563569","mechanical-alignment-vs-kalipered-kinematic-alignment-total-knee-arthroplasty-100563569","NCT06617871","Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty","A Prospective, Randomized, Single-blinded Clinical Trial Comparing Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty Using Medacta Spherika","Inclusion Criteria:\n\n* Patient undergoing primary TKA with a medially-stabilized SpheriKA knee system\n* Able to read and understand consent form and PRO instruments and willing to return for follow up visits\n\nExclusion Criteria:\n\n* Varus or Valgus malalignment \\>15 degrees to mechanical axis\n* Flexion contracture \\>15 degrees or flexion \\\u003C90 degrees\n* BMI \\>40\n* Revision TKA or other prior knee surgery other than arthroscopy or arthroscopic-assisted ligament reconstruction\n* Diagnosis or history of any of the following\n\n  * inflammatory arthritis\n  * infection in study knee\n  * chronic pain\n  * chronic opioid use\n  * metabolic musculoskeletal disorder other than osteopenia\u002Fosteoporosis\n* Patients receiving workers' compensation for study condition\n* Patients who cannot complete questionnaires in English\n* Patients with comorbidities preventing surgery\n* Patients who are not able to provide informed consent","21 Years","79 Years",{"count":156,"type":21},95,[24],"Knee replacement surgery can be performed in one of two ways. Traditionally the goal was for the new joint to be in a neutral position with respect to the femur (thigh bone). This is called Mechanical Alignment (MA). The neutral position is different than the human knee's natural position, so MA often requires the surgeon to make additional cuts to the ligaments and other soft tissue around the knee. More recently surgeons have started to place the new joint in a position that more closely replicates the natural alignment of the human knee. This is called Kinemetic Alignment (KA). KA can be done without additional soft tissue dissection but the procedure requires a higher level of precision that can be difficult to achieve in every case.\n\nSome studies have found no difference in outcomes between MA and KA, whereas others have found KA to be superior. But these were small studies or studies that did not consider patient-rated outcomes.",[27,28],[161,162],"randomized trial","knee arthroplasty",{"date":164,"type":34},"2026-03-24",{"date":166,"type":34},"2024-08-01",{"date":168,"type":21},"2028-12",{"name":170,"class":41},"Northwestern University",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":180,"briefSummary":181,"conditions":182,"keywords":183,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":4},"100560321","knee-hip-surgery-wait-list-support-program-100560321","NCT06575621","Knee-hip Surgery Wait-list Support Program","Re-imagining Hip and Knee Arthroplasty Wait-list in Nova Scotia: Pre-surgery Support Program","Inclusion Criteria:\n\n* On surgery wait list for total hip or knee arthroplasty at Valley Regional Hospital\n* 18+ and able to provide informed consent\n* Anticipated surgery time 8-16 weeks after the study start date\n\nExclusion Criteria:\n\n* Any contraindications or exclusions identified through the assessment process that are outside thresholds for acceptable surgery risk",{"count":179,"type":21},50,[24],"This project will outline a pre-surgery support program that identifies risk factors related to poor surgical outcomes and recommends actions to improve these before surgery.\n\nThe main questions this study attempts to answer are:\n\n1. Is a formalized knee-hip pre-surgery support program feasible, measured by recruitment rate, adherence, and completion rate?\n2. Does the support program improve surgical risk factors including hemoglobin A1c (HB A1C), blood pressure, hemoglobin, estimated glomerular filtration rate (eGFR), frailty score, and physical fitness and function (measured with the 2-minute step test and 30s second sit to stand test)?\n\nParticipants will participate in education, medical navigation, and exercise.",[28,92],[184,69,185,186,187],"surgery","hip","exercise","risk factors","2026-03-19",{"date":137,"type":34},{"date":191,"type":21},"2026-06-15",{"date":193,"type":21},"2027-08-30",{"name":195,"class":41},"Nova Scotia Health Authority",{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":202,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":206,"conditions":207,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":218},"100545240","evaluation-of-outcomes-of-the-triathlon-hinge-knee-thk-system-100545240","NCT06379321","Evaluation of Outcomes of the Triathlon Hinge Knee (THK) System","A Retrospective\u002FProspective, Post-market, Multi-center Evaluation of the Clinical Outcomes of the Triathlon Hinge Knee (THK) System","Hinge","Inclusion Criteria:\n\n* The subject undergoes a primary or revision procedure implanting at least the Revision Baseplate portion of the Triathlon Hinge Knee System in accordance with the Indications for Use.\n* The subject has signed an Institutional Review Board (IRB)\u002FEthical Committee (EC)-approved, study-specific Informed Consent Form (ICF).\n* The subject is a male or non-pregnant female at the time of enrollment.\n* The subject agrees to comply with the protocol-mandated clinical evaluations.\n\nExclusion Criteria:\n\n* Any active or suspected latent infection in or about the knee joint; overt infection;\n* Distant foci of infection which may cause hematogenous spread to the implant site; rapid disease progression as manifested by joint destruction or bone resorption apparent on roentgenogram;\n* skeletally immature patients;\n* Severe instability of the knee joint secondary to the absence of collateral ligament integrity and function.\n* Bone stock compromised by disease, infection or prior implantation which cannot provide adequate support and\u002For fixation to the prosthesis.\n* Known or suspected sensitivity and\u002For allergy to any material in the device.\n* Conditions presenting an increased risk of failure include:\n* uncooperative patient or patient with neurologic disorder, incapable of following instructions;\n* osteoporosis;\n* metabolic disorders which may impair bone formation or cause bone loss;\n* osteomalacia; and,\n* previous arthrodesis.\n* A higher incidence of implant failure has also occurred in paraplegics, cerebral palsy and patients with Parkinson's disease.\n* Any mental or neuromuscular disorder which would create an unacceptable risk of prosthesis instability, prosthesis fixation failure, or complications in postoperative care.\n* The subject is a prisoner",{"count":205,"type":21},200,"This study is a prospectively and retrospectively enrolled, post-market, open-label, non-randomized, single institution evaluation of clinical outcomes of primary or revision knee surgery patients who meet the eligibility criteria and received devices from the Triathlon Hinge Knee System according to its indications for use (IFU).\n\nClinical evaluation for all cases will include data collection of patient demographics, surgical details, early postoperative status, functional and clinical outcomes, and survivorship at 1, 2, 6, and 10-years.",[28,208,209],"Recurrence","Knee Infection","2026-02-27",{"date":212,"type":34},"2026-03-02",{"date":214,"type":34},"2024-05-10",{"date":216,"type":21},"2034-05-10",{"name":40,"class":41},2,{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":11,"sex":16,"minAge":226,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":22,"phases":229,"briefSummary":230,"conditions":231,"keywords":232,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":42},"100572463","femoral-bmd-change-following-cemented-or-cementless-total-knee-arthroplasty-100572463","NCT06733597","Femoral BMD Change Following Cemented or Cementless Total Knee Arthroplasty","Femoral Bone Mineral Density (BMD) Change Following Cemented or Cementless Total Knee Arthroplasty","Inclusion Criteria:\n\n* Patients age greater than or equal to 55 years undergoing TKA with no prior total joint arthroplasty on the surgical side\n* Normal BMD or osteopenia with Fracture Risk Assessment Tool (FRAX) not meeting Bone Health and Osteoporosis Foundation (BHOF) treatment recommendations, i.e., 10-year major osteoporotic fracture risk greater then or equal to 20 percent or hip fracture risk greater than or equal to 3 percent.\n\nExclusion Criteria:\n\n* Known clinical osteoporosis defined as any one of the following:\n\n  * Hip or spine T-score less than or equal to -2.5\n  * History of low trauma fracture after age 50\n  * FRAX fracture risk calculation greater than or equal to 20 percent for major osteoporotic fracture or greater than or equal to 3 percent for hip fracture\n* Prior or current use of osteoporosis medications\n* Current use of systemic glucocorticoids or bone-active medications\n* Rheumatoid arthritis\n* Laboratory abnormalities that in the opinion of study investigators may impact bone mineral density; including calcium, creatinine, albumin and parathyroid hormone (PTH)\n* 25(OH)D less than 20 ng\u002FmL\n* Not suitable for study participation due to other reasons at the investigator's discretion","55 Years",{"count":228,"type":21},100,[24],"The purpose of this study is to examine femur bone mineral density (BMD) change before and after surgery in patients receiving cemented or cementless total knee arthroplasty (TKA). performed with manual or robotic methods. 100 participants will be enrolled and can expect to be on study for up to 26 months.",[28],[233],"bone mineral density","2026-02-17",{"date":236,"type":34},"2026-02-19",{"date":238,"type":34},"2025-03-06",{"date":240,"type":21},"2028-06",{"name":242,"class":41},"University of Wisconsin, Madison",{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":252,"conditions":253,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":263},"100541996","physica-tt-tibial-plate-follow-up-study-100541996","NCT06337123","Physica TT Tibial Plate Follow up Study","A Post Market Clinical Study Evaluating Clinical and Radiographic Outcomes of Total Knee Arthroplasty With Physica Porous KR or Physica Porous PS in Combination With Physica TT Tibial Plate in Cementless Configuration.","Inclusion Criteria:\n\n1. Male or female of any race requiring a total knee replacement (TKR) and suitable for receiving Physica Porous KR or Physica Porous PS femoral component in combination with Physica TT Tibial Plate.\n2. Age ≥ 18 years old.\n3. Candidate for primary total knee replacement when clinical indications based on physical examination and medical history include one or more of the following conditions:\n\n   1. Non-inflammatory degenerative joint disease like knee osteoarthritis, post traumatic knee arthritis\n   2. Inflammatory degenerative joint disease like rheumatoid arthritis\n   3. Any other medical reason for which the investigator deems the subject as a possible candidate for total knee replacement.\n4. Patient has well-preserved and well-functioning collateral ligaments and one of the following conditions:\n\n   1. Absent or not-functioning posterior cruciate ligament and severe antero-posterior instability of the knee joint (for Physica Porous PS)\n   2. Undamaged and functional posterior cruciate ligament (for Physica Porous KR)\n5. Patient is able to understand the conditions of the study, to comply with the prescribed rehabilitation as well as willing to perform all scheduled follow-up visits.\n6. Patient signed the study-specific informed consent form approved by the ethics committee before study activities\n\nExclusion Criteria:\n\n1. Severe instability of the knee joint secondary to the absence of collateral ligament integrity and\u002For function. Only for Physica Porous KR: important joint instability and deficiency of posterior cruciate ligament.\n2. Any active or suspected infection (local or systemic) or previous history of infection that may affect the prosthetic joint.\n3. Previous partial knee replacement (unicompartmental, bicompartmental or patellofemoral joint replacement), patellectomy, high tibial osteotomy.\n4. Significant bone loss on femoral or tibial joint side.\n5. Affected by malignant cancer with life expectancy less than 2 years or where cancer treatment might affect the normal postoperative course.\n6. Known incompatibility or allergy to the product materials, and\u002For metal hypersensitivity to implant materials.\n7. Septicaemia.\n8. Persistent acute or chronic osteomyelitis.\n9. Open epiphyses (immature patient with active bone growth).\n10. Necrotic bone\n11. Arterial vascular insufficiency or nerve diseases of the lower limbs severe enough to interfere with the study evaluation.\n12. Compromised bone stock due to disease, infection or prior implantation that cannot provide adequate support and\u002For fixation to the prosthesis.\n13. Systemic or metabolic disorders leading to progressive bone deterioration, which may impair fixation and stability of the implant.\n14. Any concomitant disease and dependency that might affect the performance of the implanted prosthesis.\n15. Any clinically major pathology based on clinical medical history or any medical intervention or reason that the Investigator feels may affect the study evaluation.\n16. Neurological or musculoskeletal disorder or disease that may adversely affect gait, functional recovery and evaluation.\n17. Neuromuscular or neurosensory deficit that would hamper the performance assessment of the device.\n18. Any psychiatric illness that would prevent comprehension of the details and nature of the study.\n19. Simultaneously taking part in another surgical intervention study or pain management study that may affect with clinical study outcomes.\n20. Female patient who is pregnant, nursing, or planning a pregnancy.\n21. Important osteoporosis, haemophilic disease.\n22. Internistic problems with high risk for surgery.",{"count":251,"type":21},130,"This clinical study aims at evaluating clinical, radiographic, patient-reported outcomes of total knee arthroplasty with Physica TT Tibial Plate in combination with Physica Porous KR or Physica Porous PS up to 2 years after surgery, in order to assess the performance of the devices. Furthermore, ithe objective is to collect short-term survivorship of the implant and the incidence of early complications.",[28],"2026-01-20",{"date":256,"type":34},"2026-01-22",{"date":258,"type":34},"2025-04-15",{"date":260,"type":21},"2029-04",{"name":262,"class":124},"Limacorporate S.p.a",3,{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":270,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":272,"enrollmentInfo":273,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":218},"100510589","rate-of-return-to-sport-after-total-knee-prosthesis-comparison-of-three-types-of-prostheses-100510589","NCT05928403","Rate of Return to Sport After Total Knee Prosthesis: Comparison of Three Types of Prostheses","Rate of Return to Sport After Total Knee Prosthesis: Comparison of Three Different Types of Prostheses (Medial Pivot, Medial Bearing and Cruciate Retaining)","TKA&RTS","Inclusion Criteria:\n\n* First total knee prosthesis between 2018 and 2020;\n* Conventional alignment technique using the same surgical technique for total knee prosthesis;\n* Placement of a medial pivot prosthesis (Evolution®), mobile bearing (SCORE® Amplitude) or traditional cruciate retaining prosthesis (Stryker® Triathlon);\n* Affiliation to a social security scheme;\n* Patient having been informed and having given his oral non-objection\n\nExclusion Criteria:\n\n* Bilateral total knee prosthesis;\n* Medical history of revision of Total Knee Prosthesis;\n* Articulation malformation of the lower limbs;\n* Having undergone revision surgery;\n* Inability to understand information related to the study for linguistic, psychological, cognitive reasons;\n* Patient under legal protection, or deprived of liberty by judicial or administrative decision.","70 Years",{"count":274,"type":21},660,"The purpose of the study is the rate of return to sport (regardless of the sport envisaged) after a minimum of 3 years after total knee prosthesis.",[28],"2026-01-13",{"date":279,"type":34},"2026-01-15",{"date":281,"type":34},"2024-06-11",{"date":283,"type":21},"2026-12",{"name":285,"class":41},"GCS Ramsay Santé pour l'Enseignement et la Recherche",{"id":287,"slug":288,"hasResults":11,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":4,"eligibilityCriteria":292,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":293,"enrollmentInfo":294,"targetDuration":4,"studyType":22,"phases":296,"briefSummary":297,"conditions":298,"keywords":299,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":42},"100530075","persistent-post-surgical-pain-after-total-knee-arthroplasty-100530075","NCT06182059","Persistent Post Surgical Pain After Total Knee Arthroplasty","Enhanced Recovery After Surgery and Total Knee Replacement: A Prospective, Randomized Study on the Rule of Peripheral Nerve Blocks on Persistent Postoperative Pain Six Months After Surgery","Inclusion Criteria:\n\n* primary total knee replacement with a written informed consent\n\nExclusion Criteria:\n\n* Allergy to local anesthetics or any drugs involve in the study\n* Controindication to regional anesthesia\n* chronic use of opioids\n* BMI \\> 35 kg m2","85 Years",{"count":295,"type":21},436,[24],"Patients undergone total knee replacement are randomized to receive a \"fast track\" regional anesthesia protocol or a \"traditional\" regional anesthesia continuous infusion by both a femoral and sciatic catheter to assess if this latter technique may reduce persistent postoperative pain six months after surgery",[28],[162,300,301,302],"acute postoperative pain","persistent post surgical pain","regional anesthesia","2025-05-28",{"date":305,"type":34},"2025-06-03",{"date":307,"type":34},"2024-01-12",{"date":309,"type":21},"2027-07-31",{"name":311,"class":41},"Policlinico di Monza SpA",{"id":313,"slug":314,"hasResults":11,"nctId":315,"briefTitle":316,"officialTitle":317,"acronym":4,"eligibilityCriteria":318,"healthyVolunteers":319,"sex":16,"minAge":17,"maxAge":320,"enrollmentInfo":321,"targetDuration":4,"studyType":22,"phases":323,"briefSummary":324,"conditions":325,"keywords":329,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":42},"100590577","l-investigation-of-robotic-assisted-tka-ra-tka-with-skywalker-and-evolution-medial-pivot-knee-emp-knee-100590577","NCT06969222","l Investigation of Robotic-assisted TKA (RA-TKA) With Skywalker and Evolution Medial Pivot Knee (eMP Knee)","A Prospective Clinical Investigation of Robotic-assisted TKA (RA-TKA) With Skywalker and Evolution Medial Pivot Knee (eMP Knee)","Inclusion Criteria:\n\n1. \\>= 18 Years Male or Female\n2. With noninflammatory degenerative joint disease, inflammatory joint disease, functional deformity\n3. The subject has signed the Ethical Board approved Informed Consent Form specific to this study prior to enrollment\n4. Must be independent, ambulatory, and can comply with all post-operative evaluations and visits.\n\nExclusion Criteria:\n\n1. Subjects with poor compliance, unable to complete the trial according to the requirements or for other reasons or considered not to be suitable for inclusion by investigators.\n2. Concurrent participation in any other total hip or knee replacement studies.",true,"95 Years",{"count":322,"type":21},122,[24],"This is a prospective trial that attempts to develop evidence on the safety and performance of RA-TKA (Robotic-assisted total knee arthroplasty) with Skywalker and eMP (Evolution Medial Pivot) knee. Moreover to evaluate performance of eMP patients with Skywalker (in comparison to eMP with conventional instrumentations and non-MP TKAs)",[28,326,327,328],"Arthroplasty Complications","Robotic Assisted Arthroplasty","TKA Outcomes",[162,330,331],"Skywalker robotic System","evolution medial pivot implant","2025-05-08",{"date":334,"type":34},"2025-05-13",{"date":336,"type":34},"2023-09-05",{"date":338,"type":21},"2026-12-31",{"name":340,"class":41},"Orthopaedic Department of General University Hospital of Laria",{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":347,"eligibilityCriteria":348,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":349,"targetDuration":4,"studyType":22,"phases":351,"briefSummary":353,"conditions":354,"keywords":356,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":364,"lastUpdatePostDateStruct":365,"startDateStruct":367,"completionDateStruct":369,"leadSponsor":371,"locationsCount":42},"100541751","phase-4-veterans-enhanced-recovery-using-integrative-treatments-around-surgery-100541751","NCT06333938","Veterans Enhanced Recovery Using Integrative Treatments Around Surgery","An Effectiveness-Implementation Hybrid Study on the Use of Integrative Treatments for Perioperative Symptom Management.","VERITAS","Inclusion Criteria:\n\n* Veterans Scheduled to undergo procedures at the Durham VA\n\nExclusion Criteria:\n\n* Hearing Loss\n* Procedures on the Ear\n* Risk of Bleeding\n* Anosmia",{"count":350,"type":21},400,[352],"PHASE4","The study aims to assess the implementation and effectiveness of Integrative Treatments - Music Medicine, Aromatherapy, and Battlefield Acupuncture - in the management of perioperative pain and anxiety, and in the reduction of related pharmacologic treatments.",[355,29,28],"Anesthesia",[357,358,359,360,361,362,363],"Perioperative Care","Complementary Integrative Health (CIH)","Battlefield Acupuncture (BFA)","Music Medicine","Aromatherapy","Veterans","Integrative Treatments","2025-04-28",{"date":366,"type":34},"2025-05-01",{"date":368,"type":21},"2025-09",{"date":370,"type":21},"2027-06",{"name":372,"class":373},"Durham VA Medical Center","FED",{"id":375,"slug":376,"hasResults":11,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":293,"enrollmentInfo":381,"targetDuration":4,"studyType":22,"phases":382,"briefSummary":383,"conditions":384,"keywords":385,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":391,"lastUpdatePostDateStruct":392,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":42},"100571478","virtual-rehabilitation-platform-for-patients-with-knee-prothesis-100571478","NCT06720779","Virtual Rehabilitation Platform for Patients With Knee Prothesis","A Randomized Clinical Trial to Evaluate the Effectiveness of Telerehabilitation With Trak in Combination With the Traditional Treatment in Patients Who Have Undergone Knee Prothesis Surgery","Inclusion Criteria:\n\n* Patients aged \\>18 and ≤85 years.\n* Patients who underwent surgery for the implantation of a knee prosthesis at the Knee Unit of the Cruces University Hospital.\n* Patients who require on-site rehabilitation at the Cruces university hospital rehabilitation service.\n* Patients who have signed the Informed Consent.\n\nExclusion Criteria:\n\n* Patients with intellectual disability or cognitive impairment.\n* Patients with a history of knee infection.\n* Patients who cannot make use of mobile applications, cell phones, tablets, laptops or e- mail and who do not have the support of a family member or caregiver to provide support to make use of these technologies.\n* Patients who have not signed the Informed Consent.",{"count":5,"type":21},[24],"This clinical trial aims to evaluate the effectiveness and usability of the Trak Rehabilitation Platform in patients who have undergone knee replacement surgery. Its main questions are whether the Trak platform combined with conventional therapy helps patients achieve optimal functionality with fewer in-person sessions compared to conventional rehabilitation alone and whether the Trak platform improves adherence to treatment, independence in daily activities, and quality of life while reducing resource consumption.\n\nResearchers will compare the use of the Trak platform combined with conventional rehabilitation to standard rehabilitation practices to determine its impact on functional outcomes, patient and provider satisfaction, and resource efficiency.\n\nParticipants will:\n\n* Use the Trak Platform as part of their personalized treatment plan.\n* Attend face-to-face rehabilitation sessions as prescribed.\n* Participate in assessments to measure functionality, adherence, independence, quality of life, and resource utilization.",[28],[386,387,388,389,390],"telerehabilitation","telemedicine","exercise prescription","exercise program","knee replacement","2024-12-02",{"date":393,"type":34},"2024-12-06",{"date":395,"type":34},"2024-06-05",{"date":397,"type":21},"2025-07-05",{"name":399,"class":124},"Trak Health Solutions S.L.",{"id":401,"slug":402,"hasResults":11,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":4,"eligibilityCriteria":406,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":407,"targetDuration":4,"studyType":22,"phases":409,"briefSummary":410,"conditions":411,"keywords":413,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":420,"completionDateStruct":422,"leadSponsor":424,"locationsCount":42},"100566318","phase-4-effect-of-bupivacaine-liposomes-or-bupivacaine-for-femoral-triangle-or-adductor-block-on-analgesia-after-total-knee-replacement-100566318","NCT06653621","Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement","Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement: a Prospective, Single-center, Simple Randomized, Active-controlled, Single-blind, 2x2 Factorial Design Clinical Study","Inclusion Criteria:\n\n1. Patients with ASAI-ⅲ\n2. Receive a unilateral initial TKA\n3. Age 18-80 years old -\n\nExclusion Criteria:\n\n1. Bilateral TKA surgery\n2. TKA revision surgery\n3. Contraindications for nerve block and intraspinal anesthesia\n4. Allergies to local anesthetics\n5. Diabetic neuropathy\n6. Patients who are unable to cooperate with the evaluation\n7. Chronic use of opioid analgesics\n8. BMI≥35kg\u002Fcm2\n9. Cases of lumbar anesthesia failure requiring general anesthesia surgery\n10. Cases of nerve block failure\n\n    \\-",{"count":408,"type":21},144,[352],"The purpose of this study was to investigate the effect of bupivacaine liposomes on postoperative pain in TKA ( total knee replacement ) patients.The main questions answered are:\n\n1. Is bupivacaine liposomes superior to bupivacaine in femoral triangle block or adductor block in terms of 72 hours opioid consumption after knee replacement\n2. Which block method(Femoral triangle block or adductor block) combined with bupivacaine liposome was more effective in alleviating pain score and 72 hours opioid consumption after total knee surgery.\n\ninvestigators will investigate the effect of bupivacaine liposomes combined with bupivacaine and pure bupivacaine on pain after total knee arthroplasty using femoral triangle block or adductor block.\n\nParticipants will:\n\n1. Receive liposomal bupivacaine or bupivacaine as a regional anesthetic for femoral triangle block or adductor block under ultrasound guidance.\n2. Undergo total knee replacement surgery under spinal anesthesia.\n3. Follow-up within 72 hours after surgery , opioid consumption, NRS score, PCA（Patient controlled analgesia，PCA） data, first postoperative remedial analgesia time, quadriceps muscle strength and complications were recorded",[28,412],"Knee Arthritis",[28,414,415,416],"liposome bupivacaine","femoral nerve block","adductor canal block","2024-10-22",{"date":419,"type":34},"2024-10-24",{"date":421,"type":21},"2024-11-05",{"date":423,"type":21},"2025-12-31",{"name":425,"class":41},"Huazhong University of Science and Technology",{"id":427,"slug":428,"hasResults":11,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":4,"eligibilityCriteria":432,"healthyVolunteers":11,"sex":16,"minAge":433,"maxAge":18,"enrollmentInfo":434,"targetDuration":4,"studyType":22,"phases":436,"briefSummary":437,"conditions":438,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":446,"locationsCount":42},"100563565","influence-of-different-prostheses-on-postoperative-clinical-function-in-total-knee-arthroplasty-100563565","NCT06617819","Influence of Different Prostheses on Postoperative Clinical Function in Total Knee Arthroplasty","Influence of Different Prostheses(CR Vs. PS) on Postoperative Clinical Functional Scores in Total Knee Arthroplasty Based on Extramedullary Femoral Osteotomy Techniques and Functionalist Alignment","Inclusion Criteria:\n\n1. Age 45-80 years, any gender, BMI \\\u003C 35 kg\u002Fm2\n2. Initial diagnosis of bilateral knee OA (Kellgren-Lawrence classification grades 3 or 4). Patients who are to undergo simultaneous primary bilateral knee arthroplasty\n3. Inversion deformity ≤ 15°\n4. Posterior cruciate ligament integrity\n\nExclusion Criteria:\n\n1. History of knee surgery (ligament, osteotomy, etc.)\n2. knee flexion\\\u003C90°.\n3. flexion contracture of one knee \\> 10°\n4. Comorbidity with other diseases, such as peripheral neuropathy, malignant tumors, rheumatism, etc.\n5. Posterior cruciate ligament injury\n6. Those assessed to be intolerant of surgery","45 Years",{"count":435,"type":21},40,[24],"Exploring differences in knee function after surgery with different types of prostheses(Cruciate ligament retaining(CR) VS. posterior stabilizing(PS))",[28],"2024-09-25",{"date":441,"type":34},"2024-10-01",{"date":443,"type":21},"2024-09-30",{"date":445,"type":21},"2027-12-31",{"name":447,"class":41},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School",{"id":449,"slug":450,"hasResults":11,"nctId":451,"briefTitle":452,"officialTitle":453,"acronym":4,"eligibilityCriteria":454,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":455,"targetDuration":4,"studyType":22,"phases":457,"briefSummary":458,"conditions":459,"keywords":461,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":463,"lastUpdatePostDateStruct":464,"startDateStruct":466,"completionDateStruct":468,"leadSponsor":470,"locationsCount":42},"100557576","phase-4-modified-tips-block-for-total-knee-arthroplasty-100557576","NCT06539910","Modified TIPS Block for Total Knee Arthroplasty","Modified Triple Injection Peri-Sartorius (TIPS) Block for Postoperative Analgesia After Total Knee Arthroplasty (TKA)","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I-III\n\nExclusion Criteria:\n\n* BMI \\> 35 kg\u002Fm2 Pre-existing neurological deficit Any disability of the non-operated limb preventing fair mobilization Known contraindications to peripheral nerve block (coagulopathy or infection at the site of injection) Chronic opioid users\u002Fabusers",{"count":456,"type":21},90,[352],"The is carried out to compare triple injection peri-sartorial block to a modified block including an extra local anesthetic injection deep to the adductor longs muscle via a medial to lateral approach regarding the peri-operative analgesia following total knee arthroplasty (TKA)",[28,460],"Anesthesia, Local",[462],"Analgesia, arthroplasty, knee replacement, nerve block, peri-sartorial block, triple injection, visual analogue scale","2024-08-02",{"date":465,"type":34},"2024-08-06",{"date":467,"type":21},"2024-08",{"date":469,"type":21},"2025-03",{"name":471,"class":41},"Alexandria University",{"id":473,"slug":474,"hasResults":11,"nctId":475,"briefTitle":476,"officialTitle":477,"acronym":4,"eligibilityCriteria":478,"healthyVolunteers":319,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":479,"targetDuration":4,"studyType":22,"phases":481,"briefSummary":482,"conditions":483,"keywords":484,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":4},"100551340","non-invasive-distractor-during-knee-arthroscopy-100551340","NCT06458816","Non-Invasive Distractor During Knee Arthroscopy","The Utility of a Non-Invasive Distractor During Arthroscopy of the Knee Joint","Inclusion Criteria:\n\n* Adults ≥ 18 years of age who have capacity to provide informed consent. Eligible participants will include existing patients of Dr. DiStefano who are scheduled to undergo knee arthroscopic surgery to address meniscal pathology. Study risks, benefits and description will be provided and informed consent will be obtained.\n\nExclusion Criteria:\n\n* Patients with prior history of neurovascular deficiency or history of prior injury\n* Patients with a prior history of knee surgery\n* Patients with diagnosed knee ligament laxity or knee instability.\n* Patients that are not cleared for knee arthroscopy",{"count":480,"type":21},14,[24],"Patients will be prospectively recruited for knee joint distraction who are undergoing knee arthroscopy. Patient demographics, operative factors, and rates of medical comorbidities will be collected and evaluated. Intraoperative arthroscopic images will be evaluated by the attending Orthopaedic surgeon with standard and testing mechanism and a measuring device will be used to measure the distance between the femur and tibia in the medial and lateral compartments.",[412,28],[485,486,487,488],"arthroscopy","knee joint distraction","non invasive","sports medicine","2024-06-10",{"date":491,"type":34},"2024-06-14",{"date":493,"type":21},"2024-06",{"date":495,"type":21},"2025-01",{"name":497,"class":41},"The Taylor Collaboration",{"id":499,"slug":500,"hasResults":11,"nctId":501,"briefTitle":502,"officialTitle":503,"acronym":4,"eligibilityCriteria":504,"healthyVolunteers":11,"sex":16,"minAge":505,"maxAge":4,"enrollmentInfo":506,"targetDuration":4,"studyType":22,"phases":508,"briefSummary":509,"conditions":510,"keywords":512,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":516,"lastUpdatePostDateStruct":517,"startDateStruct":519,"completionDateStruct":521,"leadSponsor":523,"locationsCount":42},"100530001","routine-use-of-negative-pressure-wound-therapy-thr-tkr-rct-100530001","NCT06181097","Routine Use of Negative Pressure Wound Therapy THR TKR RCT","Routine Use of Negative Pressure Wound Therapy in Primary Hip and Knee Arthroplasties; a Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients undergoing total knee or total hip arthroplasty at Prince of Wales Hospital, Hong Kong.\n\nExclusion Criteria:\n\n* Patients using steroid, or other immune modulators that is known to affect wound healing, prior surgery to the knee or hip, skin condition such as eczema that would result in poor healing or widen scars, patients with a known significant history of hypertrophic scarring or keloid.","50 Years",{"count":507,"type":21},82,[24],"Negative pressure wound therapy (NPWT) for post total joint arthroplasty incisions has demonstrated benefits in reducing wound complications. A prospective randomized trial will be conducted including 40 patients who will undergo total knee and total hip arthroplasty. The number of wound complications within 21 days will be recorded. As well, the aesthetic appearance and quality of scarring of the scar will be assessed.",[28,92,511],"Negative Pressure Wound Therapy",[28,92,513,514,515],"TKR","THR","Wound therapy","2023-12-23",{"date":518,"type":34},"2023-12-29",{"date":520,"type":34},"2023-12-11",{"date":522,"type":21},"2026-12-10",{"name":524,"class":41},"Chinese University of Hong Kong"]