[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"knee-arthroplasty-total\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:knee-arthroplasty-total":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,28,0,25,[9,46,73,98,123,150,179,203,231,261,283,313,340,370,393,419,442,470,491,513,541,572,593,621,641],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100593245","remote-monitoring-after-knee-replacement-surgery-100593245",false,"NCT07003932","Remote Monitoring After Knee Replacement Surgery","OA-AID TKR","Inclusion Criteria:\n\n* Men and women, 50 years of age or older\n* Referred to total or unicondylar knee replacement surgery due to knee osteoarthritis\n\nExclusion Criteria:\n\n* Revision of previous knee replacement surgery\n* Serious comorbidities (such as severe malignancies, severe diabetes mellitus, severe infections, uncontrollable hypertension, severe cardiovascular disease, severe respiratory disease)\n* Congitive dysfunction\n* Knee replacement surgery due to trauma or inflammatory joint disease (such as psoriatic arthritis or rheumatoid arthritis)\n* Unable to understand Norwegian\n* Low digital competency\u002F cannot answer questionnaires digitally (lack BankID, do not possess a smartphone)\n* Deemed inappropriate for remote monitoring by orthopedic surgeon","ALL","50 Years",{"count":20,"type":21},140,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate the effect, cost-effectiveness, safety and satisfaction with replacing standardized, pre-scheduled face-to-face visits with remote monitoring and video consultations or face-to-face consultations only when needed after knee replacement surgery due to knee osteoarthritis.\n\nThe primary outcome is the probability of being a OMERACT-OARSI responder at 6 months post-surgery. This is a composite index where participants are classified as a responder or non-responder based on improvement in pain, function and\u002For disease activity. Health-related quality of life and healthcare costs will be used to determine cost-effectiveness. Patient-reported adverse events and statisfaction will be used to determine safety and satisfaction.\n\nPatients will be recruited from Diakonhjemmet Hospital. Patients undergoing knee replacement surgery will be randomly allocated to a control group who are summoned for a face-to-face consultation at Diakonhjemmet Hospital at 2 and 12 months, or a remote monitoring group who will not be scheduled for hospital visits but will answer patient-reported outcomes throught a web-application at 1, 2, 3, 6 and 12 months post-surgery and only be scheduled for hospital visits when needed.\n\nAn additional study with follow-up after 5 and 10 years will be conducted.",[27,28],"Knee Arthroplasty, Total","Knee Replacement Arthroplasty",[30,31,32],"knee arthroplasty","remote follow-up","non-inferiority","RECRUITING","2026-05-17",{"date":36,"type":37},"2026-05-19","ACTUAL",{"date":39,"type":37},"2025-06-04",{"date":41,"type":21},"2035-12-31",{"name":43,"class":44},"Diakonhjemmet Hospital","OTHER",1,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100633449","comparison-of-the-analgesic-efficacy-of-adductor-canal-block-and-combined-adductor-canal-block-plus-ipack-block-in-knee-surgery-100633449","NCT07526831","Comparison of the Analgesic Efficacy of Adductor Canal Block and Combined Adductor Canal Block Plus IPACK Block in Knee Surgery","Comparison of the Analgesic Efficacy of Adductor Canal Block Versus Adductor Canal Block Combined With Local Anesthetic Infiltration Between the Popliteal Artery and the Capsule of the Knee (IPACK) in Patients Undergoing Knee Surgery","Inclusion Criteria:\n\n* ASA (American Society of Anesthesiologists) I- ASA II-ASA III Patients\n\nExclusion Criteria:\n\n* history of allergy to the study medication\n* refusal to participate","18 Years",{"count":55,"type":21},60,"OBSERVATIONAL","To evaluate the effectiveness of Adductor Canal Block and combined Adductor Canal plus IPACK block in reducing postoperative pain and analgesic requirements in patients undergoing knee surgery.",[27],[60,61,62],"ultrasound","IPACK block","Adductor Canal Block","2026-05-13",{"date":65,"type":37},"2026-05-14",{"date":67,"type":21},"2026-04-15",{"date":69,"type":21},"2028-05-01",{"name":71,"class":44},"TC Erciyes University",2,{"id":74,"slug":75,"hasResults":12,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100636946","proof-of-concept-for-simulating-static-weight-bearing-exercises-in-the-supine-position-100636946","NCT07572292","Proof of Concept for Simulating Static Weight-bearing Exercises in the Supine Position","Validation and Evaluation of a Static Supine Weight-Bearing Computed Tomography Method to Enable Detection of Implant Migration After Knee Arthroplasty","SWB_PoC","Inclusion Criteria:\n\n* Healthy participants\n* Patients with TKA\n\nExclusion Criteria:\n\n* neurological conditions\n* acute trauma",true,{"count":83,"type":21},15,[24],"This project evaluates a new weight-bearing CT method to later improve early detection of implant migration after knee arthroplasty.\n\nThis method aims to allow patients to apply a controlled load during CT scanning, simulating standing conditions with real-time feedback.\n\nThe study has two phases. First, in healthy volunteers, biomechanical loading during prone simulated weight-bearing will be compared with a standard standing squat to validate the method. Second, in arthroplasty patients, standard radiographs will be compared with loaded and unloaded WBCT scans.\n\nPatients will not deviate from the standard plan of care. The CT images are additions to the standard RX images and are not intended for diagnostic purposes to the patient.\n\nThe aim is to determine whether this method opens the door for more accurate and earlier detection of implant migration than current clinical imaging in the future, potentially improving long-term outcomes after knee arthroplasty.",[27,87],"Healthy Participants","NOT_YET_RECRUITING","2026-05-04",{"date":91,"type":37},"2026-05-07",{"date":93,"type":21},"2026-05-01",{"date":95,"type":21},"2026-12-31",{"name":97,"class":44},"Vrije Universiteit Brussel",{"id":99,"slug":100,"hasResults":12,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":109,"conditions":110,"keywords":111,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":121,"locationsCount":45},"100600438","phase-4-liposomal-bupivacaine-vs-perineural-adjuvants-in-adductor-canalf-and-ipack-blocks-in-total-knee-arthroplasty-100600438","NCT07097493","Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty","Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canal and iPACK Blocks in Patients Undergoing Primary Total Knee Arthroplasty","Inclusion Criteria:\n\n* 18-80 years of age\n* Receiving primary total knee arthroplasty\n* Patients receiving a spinal anesthetic with ropivacaine and fentanyl\n* American Society of Anesthesiology (ASA) category 1 to 3\n\nExclusion Criteria:\n\n* Revision of Total Knee Arthroplasty\n* Opioid use in the prior 6 months \\> 40 mg oxycodone equivalents per day or long-acting opioids as determined by the Prescription Drug Monitoring Program (PDMP)\n* Patients planned to receive general anesthesia\n* Patients planned to receive a spinal other than ropivacaine\n* History of peripheral neuropathy\n* Poorly controlled diabetes (Hgb A1C \\>8)\n* Allergies or contraindications to study medications: acetaminophen, celecoxib (including sulfa), methocarbamol, midazolam, fentanyl, bupivacaine, dexamethasone, acetaminophen, buprenorphine, NSAIDs, clonidine, epinephrine, and liposomal bupivacaine.\n* Unable to provide informed consent",{"count":106,"type":21},90,[108],"PHASE4","The purpose of this research study is to compare two different combinations of anesthetic medications to see which works the best in providing the longest lasting pain relief for total knee arthroplasty surgery. The drugs being used are liposomal bupivacaine compared to a combination of bupivacaine, clonidine, epinephrine, buprenorphine, and dexamethasone. Pain scores will be collected at different intervals during study participation.",[27],[112,113,114],"pain","knee surgery","pain management","2026-04-22",{"date":117,"type":37},"2026-04-23",{"date":119,"type":21},"2026-08",{"date":95,"type":21},{"name":122,"class":44},"Wake Forest University Health Sciences",{"id":124,"slug":125,"hasResults":12,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":130,"targetDuration":132,"studyType":56,"phases":4,"briefSummary":133,"conditions":134,"keywords":138,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":45},"100601425","characteristics-of-persistent-pain-composition-following-total-hip-or-knee-arthroplasty-a-descriptive-study-100601425","NCT07110324","Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study","PAIN-COMPO","Inclusion Criteria:\n\n* All patients with persistent moderate-severe pain (NRS\\>3) after THA, TKA and UKA\n* Acceptance to be contacted.\n\nExclusion Criteria:\n\n* Re-operation\n* Luxation\n* Do not want to be contacted\n* Post-operative complications such as prosthesis infection, thromboembolism or fracture of the prosthesis.",{"count":131,"type":21},100,"1 Year","Despite high success rates of hip and knee arthroplasty, up to 20% of patients report moderate-to-severe pain (NRS \\> 3) persisting beyond the expected healing period. This investigator-initiated, descriptive cohort study will re-invite approximately 100 consenting patients with persistent postoperative pain-identified from a pool of \\~7 000 respondents-to complete standardized assessments of neuropathic (DN4), nociplastic (IASP criteria + Fibromyalgia Survey Questionnaire) and nociceptive (KOOS\u002FHOOS pain domains) pain. Primary outcomes are the prevalence of potential nociplastic pain and the proportion experiencing significant pain in two or more mechanistic categories. Secondary analyses will compare baseline vs. re-evaluated DN4 scores, FSQ and KOOS\u002FHOOS distributions, and examine differences between patients with and without possible neuropathic pain. Findings will inform targeted pre- and postoperative pain management strategies.",[135,136,27,137],"Pain (Visceral, Somatic, or Neuropathic)","Hip Arthroplasty Replacement","Survey and Questionnaire",[139,140,30],"Pain","hip arthroplasty","2026-03-31",{"date":143,"type":37},"2026-04-01",{"date":145,"type":37},"2025-06-26",{"date":147,"type":21},"2026-12-01",{"name":149,"class":44},"Rigshospitalet, Denmark",{"id":151,"slug":152,"hasResults":12,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":161,"conditions":162,"keywords":163,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":174,"leadSponsor":176,"locationsCount":4},"100631542","impact-of-exercise-access-on-physio-outcomes-post-knee-replacement-100631542","NCT07502040","Impact of Exercise Access on Physio Outcomes Post Knee Replacement","A Feasibility Study To Determine The Effect Of An Artificial Intelligence (AI) Based Motion Tracking Exercise Programme (Kemtai) On Amount Of Physiotherapy Contact And Length Of Hospital Stay After Knee Arthroplasty Compared With Exercise As Usual .","KEMTAI","Inclusion Criteria:\n\n1. Adults aged ≥18 years.\n2. Referred to Hull University Teaching Hospitals NHS Trust t for Knee Arthroplasty at either Castle Hill Hospital or Goole District Hospital and has access to pre operative resources offered by the joint school physiotherapists.\n3. Has access to a device which is compatible with the operational requirements of the Kemtai programme.\n4. Able to give informed consent.\n\nExclusion Criteria:\n\n• Significant comorbid physical or mental illness considered by the investigator to either: prevent engagement in modified exercise; impair the participants ability to follow instructions place the participant at undue risk during exercise training adversely affect the recovery or rehabilitation trajectory\n\n* Patients already involved in an exercise or rehabilitation study will be excluded from this study.\n* Unwilling or unable to consent or complete study measures.\n* Has insufficient understanding of English or the languages that are supported by the Kemtai programme and does not have someone who can translate.\n* Is a prisoner\n* Has had a total hip replacement within the previous 6 months.\n* Is attending for revision of a previous knee replacement\n* Is having a knee replacement due to a tumour\n* Lacks visual acuity sufficient to follow stimuli on monitor or has someone who can give necessary verbal prompts\n* Severe genu varum or genu valgum deformity which precludes the ability to exercise using the Kemtai programme.",{"count":159,"type":21},40,[24],"To stay strong, patients should do some strength training at least twice a week. However arthritic pain can limit walking and activity. The wait for knee surgery can be long, which can lead to loss of muscle strength. Patients who need a new knee joint tend to be older. If older people do not exercise and become weak, they tire easily, and may take longer to recover after surgery. Patients recover faster after having a new knee joint if their leg muscles are strong. This is why exercise before surgery can help people to make the most of their new joint. Patients come to a joint school where the investigators show them exercises and advise how to get ready for surgery. Patients are given a sheet of pictures and prompts for each exercise but the investigators know that some people don't do the exercises that they are given. Exercises are more likely to be done if they are fun, if people can see they make a difference, if they know what to do, and if their physiotherapist can check what they are doing.",[27],[164,165,166,167,168,169],"Arthroplasty","Exercise","Prehabilitation","Motion-tracking","Digital App","Artificial intelligence","2026-03-24",{"date":172,"type":37},"2026-03-30",{"date":141,"type":21},{"date":175,"type":21},"2026-11-28",{"name":177,"class":178},"Hull University Teaching Hospitals NHS Trust","OTHER_GOV",{"id":180,"slug":181,"hasResults":12,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":185,"eligibilityCriteria":186,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":187,"targetDuration":4,"studyType":22,"phases":189,"briefSummary":190,"conditions":191,"keywords":192,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":202},"100630614","functional-impact-at-12-months-post-op-of-posterior-cruciate-ligament-conservation-during-robotic-assisted-surgery-mako-for-total-knee-replacement-100630614","NCT07489963","Functional Impact at 12 Months Post-op of Posterior Cruciate Ligament Conservation During Robotic-assisted Surgery (MAKO) for Total Knee Replacement.","Evaluation of the Functional Impact at 12 Months Post-op of Posterior Cruciate Ligament Conservation During Robotic-assisted Surgery (MAKO) for Total Knee Replacement. A Randomized, Single-blind, Multicenter, Controlled Superiority Study.","LCPTG","Inclusion Criteria:\n\n* Patient scheduled for first-intention robotic-assisted total knee replacement (MAKO).\n* Unilateral replacement, regardless of laterality.\n* Patient able to answer questionnaires.\n* Patient willing to undergo usual 12-month follow-up.\n* Patient has given free and informed consent and has signed the consent form.\n* Patient affiliated with or benefiting from a health insurance scheme.\n\nExclusion Criteria:\n\n* Patient with intraoperative technical impossibility of retaining PCL (flessum \\> 20°, flexion stiffening \\\u003C 100°).\n* Previous posterior cruciate ligament surgery.\n* Post-traumatic gonarthrosis.\n* Valgus \\> 185°.\n* Patient with septic complication.\n* Patient participating in another interventional trial.\n* Patient in an exclusion period determined by another study.\n* Patient under court protection, guardianship or curatorship.\n* Patient unable to give consent.\n* Patients for whom it is impossible to provide informed information.\n* Pregnant women",{"count":188,"type":21},300,[24],"Studies have been made on the best way to do knee surgery and whether to conserve the posterior cruciate ligament or not during total knee prosthesis insertion is still under debate. However, most of these studies were made before the introduction of robotic knee surgery. It seems timely to do a study comparing these two surgical techniques: preservation versus removal of the posterior cruciate ligament in knee arthroplasty",[27],[193,27],"Robot-Assisted Surgery",{"date":195,"type":37},"2026-03-27",{"date":197,"type":37},"2025-10-10",{"date":199,"type":21},"2028-09-01",{"name":201,"class":44},"Centre Hospitalier Universitaire de Nīmes",3,{"id":204,"slug":205,"hasResults":12,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":4,"eligibilityCriteria":209,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":210,"enrollmentInfo":211,"targetDuration":4,"studyType":22,"phases":213,"briefSummary":214,"conditions":215,"keywords":220,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":4},"100626011","phase-4-post-operative-pain-relief-zynrelef-or-periarticular-injections-in-ratka-100626011","NCT07430085","Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA","Postoperative Pain Outcomes After Use of Bupivacaine-Meloxicam Extended-Release Solution in Robot Assisted Total Knee Arthroplasty: A Prospective Study","Inclusion Criteria:\n\nMales or females aged 18-89 years\n\nDiagnosed with knee osteoarthritis requiring surgical intervention\n\nIndicated for unilateral RATKA\n\nExclusion Criteria:\n\nPediatric, pregnant, or incarcerated patients\n\nBMI of more than 45 kg\u002Fm2\n\nProlonged opioid use history of \\>5 mg\u002Fday for \\>1 month\n\nHistory of contralateral TKA \\\u003C2 years prior to the index TKA\n\nType 1 Hypersensitivity to NSAIDs or local anesthetics\n\nDiagnosis of severe renal disease","89 Years",{"count":212,"type":21},150,[108],"Prospective Cohort of patients who are scheduled for a Robot Assisted Total Knee Arthroplasty (RATKA). A prospective survey of patient reported outcome measures (Numeric Rating Scale) will be obtained postoperatively of 72 hours, as well as at the postoperative opioid consumption after 72 hours.",[216,217,218,219,27],"Periarticular Block","Osteoarthritis (OA)","Osteoarthritis (OA) of the Knee","Pain After Surgery",[221],"Zynrelef","2026-02-24",{"date":224,"type":37},"2026-02-27",{"date":226,"type":21},"2026-01-31",{"date":228,"type":21},"2028-02-28",{"name":230,"class":44},"Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)",{"id":232,"slug":233,"hasResults":12,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":237,"eligibilityCriteria":238,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":239,"targetDuration":4,"studyType":22,"phases":240,"briefSummary":241,"conditions":242,"keywords":247,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":45},"100625655","cryoneurolysis-prior-to-total-knee-arthroplasty-cryo-tka-trial-100625655","NCT07425457","Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)","Association of Pre-operative Genicular Nerves Cryoneurolysis With Improved Pain and Function in Patients Undergoing Total Knee Arthroplasty","CRYO-TKA","Inclusion Criteria:\n\n* Adults ≥18 years undergoing primary TKA for osteoarthritis.\n* Cognitively normal and able to self-assess pain and function.\n* Provide written informed consent.\n\nExclusion Criteria:\n\n* Cancer-related knee pain.\n* Neurological, psychiatric, or medical conditions interfering with assessment.\n* Chronic opioid users.",{"count":131,"type":21},[24],"Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.",[164,243,244,27,245,246],"Replacement Material","Knee Arthritis Osteoarthritis","Genicular Nerves","Chronic Pain",[248,249,250,251],"Cryoneurolysis","Interventional Radiology","Pain Management","Post-operative recovery","2026-02-19",{"date":254,"type":37},"2026-02-20",{"date":256,"type":37},"2026-01-02",{"date":258,"type":21},"2028-03-31",{"name":260,"class":44},"Attikon Hospital",{"id":262,"slug":263,"hasResults":12,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":4,"eligibilityCriteria":267,"healthyVolunteers":12,"sex":17,"minAge":268,"maxAge":4,"enrollmentInfo":269,"targetDuration":4,"studyType":22,"phases":271,"briefSummary":272,"conditions":273,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":45},"100625105","comparison-between-combined-biceps-femoris-short-head-block-and-adductor-canal-block-versus-genicular-nerve-block-100625105","NCT07418307","Comparison Between Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Block","Enhanced Analgesia in Elderly After Total Knee Arthroplasty Using Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Block","Inclusion Criteria:\n\n* patient acceptance\n* Physical status: ASA I, II and Ⅲ.\n* Body mass index (BMI): 18.5 - 35 kg\u002Fm2.\n* Type of operations: total knee arthroplasty.\n\nExclusion Criteria:\n\n* Known hypersensitivity to dexamethasone or bupivacaine.\n* Coagulation disorders or taking drugs affect surgical hemostasis.\n* Patients with pre-existing neurological deficits.\n* Uncooperative patient or with altered mental status.\n* Patient with advanced cardiovascular or respiratory diseases or uncontrolled diabetes","65 Years",{"count":270,"type":21},50,[24],"The purpose of this study is to compare the analgesic outcomes (time to first analgesic request, total amount of analgesic consumption, and pain scores) following total knee arthroplasty by either combined biceps femoris short head block and adductor canal block or genicular nerve block in elderly patients.",[27],"2026-02-11",{"date":276,"type":37},"2026-02-18",{"date":278,"type":21},"2026-02-15",{"date":280,"type":21},"2026-11-15",{"name":282,"class":178},"Zagazig University",{"id":284,"slug":285,"hasResults":12,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":290,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":291,"conditions":292,"keywords":298,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":304,"lastUpdatePostDateStruct":305,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":45},"100612666","machine-learning-for-predicting-spinal-anesthesia-duration-100612666","NCT07256548","Machine Learning for Predicting Spinal Anesthesia Duration","Comparative Evaluation of Machine Learning Algorithms for Predicting Spinal Anesthesia Termination Time","Inclusion Criteria:\n\n1. Patients scheduled to undergo total knee arthroplasty between November 2025 and March 2026 at the Kocaeli City Hospital Operating Theaters.\n2. Patients who have provided written informed consent to participate in the study.\n3. Patients whose surgery is planned under spinal anesthesia.\n4. Patients for whom complete clinical data can be obtained during the study period.\n5. Adults aged 18 years or older, classified as American Society of Anesthesiologist's (ASA) Physical Status I or II.\n\nExclusion Criteria:\n\n1. Patients who were converted to general anesthesia during surgery or initially operated under general anesthesia.\n2. Patients who required postoperative intensive care unit (ICU) admission following anesthesia.\n3. Patients who developed surgical complications and for whom postoperative mobilization could not be planned.\n4. Patients with cognitive impairment preventing them from completing pain assessment scales in the postoperative period.\n5. Patients with neuropathic pain, multiple sclerosis, or other neuromotor disorders will be excluded from the study.",{"count":20,"type":21},"Spinal anesthesia provides significant advantages over general anesthesia in knee arthroplasty, including reduced blood loss, faster recovery, and fewer complications. However, predicting its duration is critical for patient safety and effective postoperative management. This study evaluates the usability of machine learning (ML) algorithms to predict the termination time of spinal anesthesia and the patient's readiness for mobilization. Using demographic, surgical, and anesthetic variables, ML models were trained to estimate anesthesia duration. Accurate predictions may improve intraoperative planning, optimize postoperative care, and enhance patient outcomes. Integrating ML-based predictive systems into anesthesia practice can contribute to safer, more efficient, and personalized perioperative management.",[293,294,27,295,296,297],"Spinal Anesthesia","Machine Learning","Spinal Anesthesia Duration","Postoperative Care","Postoperative Acute Pain",[299,300,301,302,303],"spinal anesthesia","machine learning","Knee arthroplasty","spinal anesthesia duration","Acute postoperative pain","2025-12-01",{"date":306,"type":37},"2025-12-08",{"date":308,"type":37},"2025-10-31",{"date":310,"type":21},"2026-03-01",{"name":312,"class":178},"Kocaeli City Hospital",{"id":314,"slug":315,"hasResults":12,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":4,"eligibilityCriteria":319,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":320,"targetDuration":4,"studyType":22,"phases":321,"briefSummary":322,"conditions":323,"keywords":326,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":336,"leadSponsor":338,"locationsCount":45},"100610915","comparison-of-acb-with-acb-and-bifes-combination-in-knee-arthroplasty-surgeries-100610915","NCT07233785","Comparison of ACB With ACB and BiFeS Combination in Knee Arthroplasty Surgeries","Comparison of the Postoperative Analgesic Efficacy of the Combination of Adductor Canal Block and Biceps Femoris Short Head Block Versus Adductor Canal Block Alone in Patients Undergoing Total Knee Arthroplasty","Inclusion Criteria:\n\n* Adult patients over 18 years of age who underwent percutaneous nephrolithotomy under general anesthesia and were I-II-III according to the American Society of Anesthesiologists (ASA) risk classification were included in the study.\n\nExclusion Criteria:\n\n* patients who did not give consent,\n* patients with coagulopathy,\n* patients with signs of infection at the block application site,\n* patients using anticoagulants,\n* patients with known allergies to any of the study drugs,\n* patients with unstable hemodynamics,\n* patients who could not cooperate during postoperative pain assessment\n* patients who wanted to withdraw from the study,\n* patients with alcohol and drug addiction,\n* patients with musculoskeletal abnormalitie",{"count":55,"type":21},[24],"The aim is to compare the postoperative analgesic effects of Adductor Canal and Biceps Femoris Short Head Blocks with Adductor Canal Block in patients undergoing Knee Arthroplasty surgery",[324,325,27],"Postoperative Pain Management","Knee Surgery",[327,30,328,329,330,331],"postoperative pain","biceps femoris short head","bifes","adductor canal blok","regional anesthesia","2025-11-20",{"date":334,"type":37},"2025-11-25",{"date":332,"type":21},{"date":337,"type":21},"2026-11-25",{"name":339,"class":44},"Cumhuriyet University",{"id":341,"slug":342,"hasResults":12,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":346,"eligibilityCriteria":347,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":348,"targetDuration":4,"studyType":22,"phases":350,"briefSummary":351,"conditions":352,"keywords":354,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":369},"100590771","haka-routine-follow-up-at-1-year-after-hip--or-knee-arthroplasty-wasting-resources-or-appropriate-healthcare-100590771","NCT06971757","HAKA: Routine Follow-Up at 1 Year After Hip- or Knee Arthroplasty: Wasting Resources or Appropriate Healthcare?","Cost-effectiveness of Routine Follow-up at One Year After Total Hip and Knee Arthroplasty Compared to Check-up on Demand: a Multicenter Hybrid Stepped-wedge Cluster De-implementation Study","HAKA 1year FU","Inclusion Criteria:\n\n* Painful and disabled hip or knee joint resulting from osteoarthritis\n* Scheduled for primary THA or TKA surgery\n* Age 50 years or older at the time of THA or TKA\n* Capable and willing to complete questionnaires\n* Proficient in Dutch or English\n* Willing to provide informed consent\n\nExclusion Criteria:\n\n* Other indication for surgery than osteoarthritis\n* Scheduled for hip or knee revision arthroplasty, except a conversion from unicompartmental knee arthroplasty to TKA or from hip hemiarthroplasty\u002Fresurfacing to THA\n* Already participating in this study due to a previous hip or knee surgery",{"count":349,"type":21},1000,[24],"After undergoing total hip or total knee arthroplasty, current guidelines recommend routine follow-up with an X-ray within 3 months and again at 1 year. Follow-up at 5 years (for hip arthroplasties) or every 5 years (for knee arthroplasties) is also considered worthwhile according to the guideline. However, these follow-up appointments require considerable time from patients, caregivers, and healthcare professionals, and it is unclear whether they are truly beneficial. It is possible that a single follow-up within 3 months is sufficient. This could potentially prevent over 100,000 unnecessary hospital visits per year, resulting in significant cost savings. If patients or healthcare providers have concerns, they can always request an additional follow-up.\n\nThe HAKA trial consists of three different work packages (WPs). This trial (WP1) investigates the 1-year follow-up, WP2 examines the 10-year follow-up, and WP3 is a qualitative study exploring the experiences and perceptions of patients and healthcare professionals. The aim of the HAKA trial is to safely reduce routine follow-up appointments after total hip or knee arthroplasty and to revise current clinical guidelines accordingly.",[353,27],"Hip Arthroplasty, Total",[355,356,357,358,359],"total hip arthroplasty","total knee arthroplasty","follow-up","PROMIS physical function","healthcare consumption","2025-11-14",{"date":362,"type":37},"2025-11-18",{"date":364,"type":37},"2025-07-01",{"date":366,"type":21},"2029-12-31",{"name":368,"class":44},"JointResearch",9,{"id":371,"slug":372,"hasResults":12,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":376,"eligibilityCriteria":377,"healthyVolunteers":12,"sex":17,"minAge":378,"maxAge":4,"enrollmentInfo":379,"targetDuration":4,"studyType":22,"phases":381,"briefSummary":382,"conditions":383,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":391,"locationsCount":45},"100562867","cas-vs-standard-technique-in-tka-comparison-of-clinical-and-functional-results-100562867","NCT06608745","CAS vs Standard Technique in TKA: Comparison of Clinical and Functional Results","CAS vs Tecnica Chirurgica Standard Nella Protesi Totale di Ginocchio: Confronto Dei Risultati Clinico-funzionali","CAS-K","Inclusion Criteria:\n\n* Patients with primary or secondary gonarthrosis with indication for knee arthroplasty with primary implant\n* Males and females aged ≥ 45\n* Willingness to participate in the study\n* Acquisition of informed consent to participate\n\nExclusion Criteria:\n\n* Patients who are not capable of understanding and willing, and therefore unable to express consent to participation in the study\n* Patient refusal to participate in the study and to sign the informed consent\n* Nickel allergy (suspected or diagnosed)\n* Pregnant women or women of childbearing age who cannot exclude pregnancy","45 Years",{"count":380,"type":21},160,[24],"The study involves the enrollment of a sample of patients with indication for total knee replacement surgery in order to compare the conventional surgical technique currently used in the reference departments with the surgical technique with the aid of computer-assisted navigation.\n\nThe comparison between the two techniques will be performed in terms of clinical-functional results, perioperative bleeding and healthcare costs (surgical time, hospital stay).\n\nThe research protocol involves the participation of 160 total patients divided into two groups, of 80 patients each, by type of surgical technique.",[27],"2025-09-19",{"date":386,"type":37},"2025-09-22",{"date":388,"type":37},"2024-02-12",{"date":390,"type":21},"2026-08-12",{"name":392,"class":44},"Istituto Ortopedico Rizzoli",{"id":394,"slug":395,"hasResults":12,"nctId":396,"briefTitle":397,"officialTitle":397,"acronym":4,"eligibilityCriteria":398,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":399,"enrollmentInfo":400,"targetDuration":4,"studyType":22,"phases":402,"briefSummary":403,"conditions":404,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":410,"lastUpdatePostDateStruct":411,"startDateStruct":413,"completionDateStruct":415,"leadSponsor":417,"locationsCount":45},"100599804","phase-4-the-perioperative-outcome-of-epinephrine-infusion-and-tranexamic-acid-in-knee-arthroplasty-surgery-100599804","NCT07089251","The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery","Inclusion Criteria:\n\n* Patients undergoing knee joint arthroplasty.\n* Saudi and Non-Saudi Patient.\n* Patients who have Complete medical record.\n\nExclusion Criteria:\n\n* End stage renal disease\n* Liver cirrhosis\n* Coagulopathy\n* Pre-operative Hgb \\\u003C10 5.\n* History of cerebrovascular accident or myocardial infarction in past 12 months.\n* History of Heart failure.\n* History of arrhythmia.\n* History of pheochromocytoma, thyrotoxicosis and glaucoma.\n* Pregnancy or breast feeding\n* History of Deep venous thrombosis or pulmonary embolism\n* Allergy to epinephrine or tranexamic acid","70 Years",{"count":401,"type":21},80,[108],"The aim of this clinical trial is to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative blood loss, thromboembolic complications, and hospitalization duration in patients undergoing knee joint arthroplasty.\n\nAlso aim to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative thromboembolic complications, and hospitalization duration",[27,405,406,407,408,409],"Knee Arthritis, Osteoarthritis","Total Knee Anthroplasty","Blood Loss","Tranexamic Acid Use","Epinephrine","2025-07-21",{"date":412,"type":37},"2025-07-28",{"date":414,"type":37},"2025-07-15",{"date":416,"type":21},"2027-06-24",{"name":418,"class":44},"King Abdullah International Medical Research Center",{"id":420,"slug":421,"hasResults":12,"nctId":422,"briefTitle":423,"officialTitle":423,"acronym":424,"eligibilityCriteria":425,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":426,"targetDuration":4,"studyType":22,"phases":428,"briefSummary":429,"conditions":430,"keywords":431,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":440,"locationsCount":45},"100598367","haka-routine-follow-up-at-10-years-after-hip--or-knee-arthroplasty-wasting-resources-or-appropriate-healthcare-100598367","NCT07070570","HAKA: Routine Follow-up at 10 Years After Hip- or Knee Arthroplasty: Wasting Resources or Appropriate Healthcare?","HAKA 10 years","Inclusion Criteria:\n\n* Underwent primary THA or TKA approximately 10 years ago\n* Age 50 years or older at time of THA or TKA\n* Capable and willing to complete questionnaires (when applicable)\n* Understanding Dutch or English\n* Willing to provide written informed consent in case the patient will complete questionnaires\n\nExclusion Criteria:\n\n* Other indication for surgery than osteoarthritis\n* Deceased\n* Revision arthroplasty of hip or knee, except a conversion from unicompartmental knee arthroplasty to TKA or from hip hemiarthroplasty\u002Fresurfacing to THA\n* Already participating in this study due to another hip or knee surgery",{"count":427,"type":21},1500,[24],"After undergoing total hip or total knee arthroplasty, current guidelines recommend routine follow-up with an X-ray within 3 months and again at 1 year. Follow-up at 5 years (for hip arthroplasties) or every 5 years (for knee arthroplasties) is also considered worthwhile according to the guideline. However, these follow-up appointments require considerable time from patients, caregivers, and healthcare professionals, and it is unclear whether they are truly beneficial. It is possible that a single follow-up within 3 months is sufficient. This could potentially prevent over 100,000 unnecessary hospital visits per year, resulting in significant cost savings. If patients or healthcare providers have concerns, they can always request an additional follow-up.\n\nThe HAKA trial consists of three different work packages (WPs). This trial (WP2) investigates the 10-year follow-up, WP1 examines the 1-year follow-up, and WP3 is a qualitative study exploring the experiences and perceptions of patients and healthcare professionals. The aim of the HAKA trial is to safely reduce routine follow-up appointments after total hip or knee arthroplasty and to revise current clinical guidelines accordingly.",[353,27],[432,433],"Routine follow-up","Check-up on demand","2025-07-14",{"date":436,"type":37},"2025-07-17",{"date":438,"type":21},"2025-09-01",{"date":366,"type":21},{"name":441,"class":44},"Reinier Haga Orthopedisch Centrum",{"id":443,"slug":444,"hasResults":12,"nctId":445,"briefTitle":446,"officialTitle":447,"acronym":448,"eligibilityCriteria":449,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":450,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":451,"conditions":452,"keywords":453,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":45},"100596136","perceptions-of-de-implementing-routine-follow-ups-after-hip-and-knee-arthroplasty-100596136","NCT07041528","Perceptions of De-implementing Routine Follow-ups After Hip and Knee Arthroplasty","How Do Patients and Health Care Professionals Perceive De-implementation of Routine Follow-ups After Total Hip and Knee Arthroplasty? Protocol for a Nested Qualitative Study Within a Hybrid De-implementation Trial","HAKA-QUALI","Inclusion Criteria:\n\n• A good command of the Dutch language\n\nExclusion Criteria:\n\n* N\u002FA",{"count":106,"type":21},"After undergoing total hip or total knee arthroplasty, current guidelines recommend routine follow-up with an X-ray within 3 months and again at 1 year. Follow-up at 5 years (for hip arthroplasties) or every 5 years (for knee arthroplasties) is also considered worthwhile according to the guidelines. However, these follow-up appointments require considerable time from patients, caregivers, and healthcare professionals, and it is unclear whether they are truly beneficial. It is possible that a single follow-up within 3 months is sufficient. This could potentially prevent over 100,000 unnecessary hospital visits per year, resulting in significant cost savings. If patients or healthcare providers have concerns, they can always request an additional follow-up.\n\nThe HAKA trial consists of three different work packages (WPs).The quantitative work packages 1 (WP1) and 2 (WP2) will investigate the 1-year and 10-year follow-up. The qualitative third work package (WP3) will explore and compare the patients' and health care professionals' (HCPs) experiences with, and perceptions about, RFU and COD after total hip and knee arthroplasty. The aim of the overarching HAKA-trial is to safely reduce routine follow-up appointments after total hip or knee arthroplasty and to revise current clinical guidelines accordingly.",[353,27],[454,164,455,456,457,458,459,460,461],"Aftercare","Focus Groups","Hip","Interview [Publication Type]","Knee","Osteoarthritis","Patient Acceptance of Health Care","Qualitative Research",{"date":463,"type":37},"2025-06-27",{"date":465,"type":21},"2026-09-01",{"date":467,"type":21},"2028-06-01",{"name":469,"class":44},"Tergooi Medical Center",{"id":471,"slug":472,"hasResults":12,"nctId":473,"briefTitle":474,"officialTitle":475,"acronym":4,"eligibilityCriteria":476,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":477,"targetDuration":4,"studyType":22,"phases":479,"briefSummary":480,"conditions":481,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":482,"lastUpdatePostDateStruct":483,"startDateStruct":485,"completionDateStruct":487,"leadSponsor":489,"locationsCount":45},"100574362","effect-of-artificial-intelligence-assisted-motivational-talk-on-patients-fear-of-movement-and-mobility-level-after-knee-replacement-100574362","NCT06758297","Effect of Artificial Intelligence-Assisted Motivational Talk on Patients' Fear of Movement and Mobility Level After Knee Replacement","Effect of Artificial Intelligence-Assisted Motivational Talk on Patients' Fear of Movement and Mobility Level After Knee Replacement: a Randomized Controlled Trial","Inclusion Criteria:\n\n* The patient must have had knee replacement surgery,\n* Be over 18 years of age,\n* Agree to participate in the study,\n* Be able to understand and speak Turkish,\n* Be able to read and write\n\nExclusion Criteria:\n\n* Cancellation or postponement of patient's surgery\n* Patients in pain,\n* Those whose walking is not recommended by the physician,\n* Those with mental disabilities or psychological disorders,\n* Patients who are alcohol or drug addicts,\n* Those with hearing or visual impairments,\n* Patients who do not want to use the headphones that will be used in the study.",{"count":478,"type":21},76,[24],"Patients may have fears about moving after TKA surgery. This fear has been described in the literature. Fear of re-injury has also been called kinesiophobia, which is the primary psychosocial structure in the fear-avoidance model. Injury or surgery can create feelings of uncertainty and fear of how much the injury will affect future function. This situation causes the individual to have negative attitudes towards activity. For this reason, kinesiophobia is a psychological element that can affect patient outcomes and recovery after knee trauma or knee surgery. Kinesiophobia is considered a normal reaction in the early postoperative period. However, it can affect patients' early mobility after TKA. It is important to improve functional outcomes in the early period, especially in knee surgeries. Patients may delay mobilization because they feel a fear of falling after surgery, and as this delay increases, their mobility is affected worse. The only solution to this situation, which can enter a vicious circle, is to determine patients' fear of falling and apply interventions accordingly. There are studies in the literature evaluating the fear of movement after total knee arthroplasty and its effect on patients' mobility levels. However, no study has been found investigating the effect of a motivational speech prepared with the help of artificial intelligence on patients. The World Health Organization (WHO) has published a four-year global strategy report on digital health within the scope of the vision of health everywhere and for everyone. According to this report, digital health is defined as \"the adoption of digital technologies to improve and develop health\". The use of artificial intelligence technology is increasing day by day in the changing and developing world. It is known that nurses constitute 45% of all health professionals in the field of health and that insufficient staff number continues to be a priority problem. It is expected that insufficient staff will be supported and efficiency will increase with the contribution of artificial intelligence, which is the copy of human intelligence with advanced technology. With this research, we aim to both support staff and improve patient outcomes by using artificial intelligence technologies. The aim of this study is to evaluate the effect of an artificial intelligence-supported motivational speech on patients' fear of movement and mobility level after knee replacement.",[27],"2025-03-24",{"date":484,"type":37},"2025-03-25",{"date":486,"type":37},"2024-12-30",{"date":488,"type":21},"2025-06-30",{"name":490,"class":44},"Kocaeli University",{"id":492,"slug":493,"hasResults":12,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":497,"eligibilityCriteria":498,"healthyVolunteers":12,"sex":17,"minAge":499,"maxAge":4,"enrollmentInfo":500,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":502,"conditions":503,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":504,"lastUpdatePostDateStruct":505,"startDateStruct":507,"completionDateStruct":509,"leadSponsor":511,"locationsCount":45},"100581192","maximal-and-self-selected-walkingspeed-after-knee-arthroplasty---a-prospective-cohort-study-100581192","NCT06847113","Maximal and Self-selected Walkingspeed After Knee Arthroplasty - a Prospective Cohort Study","MAXIMAL and SELF-SELECTED WALKING SPEED AFTER KNEE ARTHROPLASTY","LOVKNEE","Inclusion Criteria: age 55 +, living in or near the city of Oslo (up to appox 2 hours commute), sceduled for primary knee arthroplasty, able to walk independently with or without walking aids, understand and speak Norwegian sufficently to take instructions and respond to questionnaires\n\nExclusion Criteria:\n\nOther reasons than osteoarthritis for knee arthroplasty, revision due to infection or failure, arthroplasty in the same or other limb during the 12 months time period, severe neurological or ohter types of disease that affects walking (e.g MS; parkinsonism, hemiplegiea)","55 Years",{"count":501,"type":21},130,"The purpose of this prospective study is to explore whether maximal and self-selected walking speed in individuals with knee arthroplasty is a useful and applicable clinical measure that can provide new insights into physical function after prosthetic surgery. We will examine the progression of walking speed and other measures of physical function, and investigate if walking speed can predict postoperative function. Individuals over 55 years, scheduled for knee arthroplasty will be invited to participate. Standardized functional tests such as walking speed, sit to stand and one legged stance along with patient reported outcomes will be assessed preoperatively, three months and 12 months after surgery. The study may provide useful knowledge that can be aplied clinically in the assessment and follow-up of this patient group.",[27],"2025-02-21",{"date":506,"type":37},"2025-02-26",{"date":508,"type":37},"2024-11-20",{"date":510,"type":21},"2026-04",{"name":512,"class":44},"Lovisenberg Diakonale Hospital",{"id":514,"slug":515,"hasResults":12,"nctId":516,"briefTitle":517,"officialTitle":518,"acronym":519,"eligibilityCriteria":520,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":521,"enrollmentInfo":522,"targetDuration":4,"studyType":22,"phases":524,"briefSummary":525,"conditions":526,"keywords":527,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":533,"startDateStruct":535,"completionDateStruct":537,"leadSponsor":539,"locationsCount":45},"100573429","block-study-better-local-orthopedic-pain-control-after-knee-arthroplasty-100573429","NCT06746168","BLOCK-study: Better Local Orthopedic Pain Control After Knee Arthroplasty","Infiltration of Local Anesthetics Between the Popliteal Artery and Capsule of the Knee (iPACK) With Femoral Triangle Block (TFB) Versus Surgical Local Infiltration Analgesia (LIA) in Unilateral Total Knee Arthroplasty (TKA): A Multicenter Double-blind, Prospective Randomized Controlled Study.","BLOCK","Inclusion Criteria:\n\n* ASA I-III\n* BMI 17-35 kg\u002Fm2\n* Patient is able to give informed consent\n* Patient is scheduled for TKA\n\nExclusion Criteria:\n\n* Refusal of patient\n* Inability to communicate due to language or neurologic barriers\n* Bilateral TKA or unilateral knee arthroplasty\n* Chronic opioid use (including partial opioid agonists) + chronic pain patients:\n* Use of atypical analgesics (gabapentin, pregabalin, …)\n* History of Sudeck atrophy\n* History of \\>3 chronic pain consultations\n* Contraindications for spinal anesthesia\n* Patient refusal\n* Local infection\n* Aberrant coagulation (according to the latest ESRA guidelines)\n* Severe spinal canal stenosis\n* Intracranial hypertension\n* History of neurological injury in the affected limb\n* Contraindications for local anesthetics\n* Allergy for local anesthetics\n* Absolute contraindications for NSAIDs or paracetamol\n* Proven allergy for NSAID's (including ASA syndrome) or paracetamol\n* Severe renal function impairment (eGFR \\\u003C30 ml\u002Fmin\u002F1.73 m2)\n* Active or recent (\\\u003C6 months) history of gastric ulcera\u002Fperforations\u002Fbleeding\n* Crohn disease or colitis ulcerosa\n* Liver function impairment or severe renal function impairment (eGFR \\\u003C30 ml\u002Fmin\u002F1.73 m2)\n* Pregnancy or breast-feeding","85 Years",{"count":523,"type":21},210,[24],"The goal of this study is to compare the anesthetic combination iPACK with femoral triangle block versus surgical LIA for unilateral TKA. We hypothesize that an iPACK block with femoral triangle block is non-inferior to surgical LIA. Furthermore, due to visualization of the relevant neural and vascular structures, the risk of accidental popliteal block, nerve damage or LAST with (a blindly performed) LIA could theoretically be reduced.",[27],[528,529,530,531],"iPACK","Femoral Triangle Block","Local infiltration analgesia","knee arthoplasty","2025-02-18",{"date":534,"type":37},"2025-02-20",{"date":536,"type":37},"2025-01-09",{"date":538,"type":21},"2027-11-30",{"name":540,"class":44},"Jessa Hospital",{"id":542,"slug":543,"hasResults":12,"nctId":544,"briefTitle":545,"officialTitle":546,"acronym":547,"eligibilityCriteria":548,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":549,"targetDuration":4,"studyType":22,"phases":551,"briefSummary":552,"conditions":553,"keywords":558,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":563,"lastUpdatePostDateStruct":564,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":569,"locationsCount":571},"100580631","digital-knee-study-adequately-diagnosing-total-knee-arthroplasty-loosening-by-evaluating-the-atmoves-knee-system-in-a-routine-clinical-setting-100580631","NCT06839807","DIGITAL-KNEE Study: Adequately Diagnosing Total Knee Arthroplasty Loosening by Evaluating the AtMoves Knee System in a Routine Clinical Setting","Adequately Diagnosing Total Knee Arthroplasty Loosening: A Randomized Controlled Trial Evaluating the AtMoves Knee System in a Routine Clinical Setting","DigitalKnee","Inclusion Criteria:\n\n* Age 18 years or older.\n* Subjects must have underwent either unilateral or bilateral TKA surgery.\n* Aseptic loosening is one of the differential diagnoses of the treating orthopaedic surgeon\n* The treating Orthopaedic Surgeon is uncertain of the diagnosis after anamnesis, physical examination and conventional x-ray.\n* The surgeon wants additional examinations or additional imaging to arrive at the diagnosis and proposal for treatment.\n* Subjects must be capable of giving informed consent and must be willing to undergo examination with the AtMoves Knee System.\n\nExclusion Criteria:\n\n* A clear other cause for complaints other than aseptic loosening (e.g. septic loosening, neuropathic pain, non-consolidated peri-prosthetic fracture of the bone around the TKA)\n* Surgical interventions of the index knee in the year prior to the start of the complaints associated with TKA loosening.\n* Posttraumatic or congenital deformation of the leg for which the loading device does not fit.\n* Pregnancy or suspected pregnancy.\n* Unable or unwilling to understand or sign the informed consent for this study and to undergo examination with the AtMoves Knee System.",{"count":550,"type":21},124,[24],"The goal of the clinical trial is to evaluate the efficacy of the AtMoves Knee System in the clinical diagnostic process of aseptic loosening in patients with a knee prosthesis. The main question it aims to answer is:\n\nDoes the use of the AtMoves Knee System reduce the percentage of failed outcomes? A \"failed outcome\" is defined as a change in the patient-reported Knee injury and Osteoarthritis Outcome Score (KOOS-PS) that is lower than the minimal clinically important difference at 12 months.\n\nResearchers will compare two groups: The first group will undergo an additional CT scan using the AtMoves Knee System. The second group will not undergo these scans. Both groups are allowed to undergo additional diagnostic measures. Researchers will compare the percentage of \"failed outcomes\" between these groups.\n\nDuring the one-year follow-up, participants in both groups will be asked to fill out questionnaires.",[554,555,556,27,557],"Aseptic Loosening","Aseptic Loosening of Prosthetic Joint","Aseptic Loosening of Orthopaedic Hardware","Total Knee Arthroplasty (Replacement)",[559,560,561,562,301],"Aseptic loosening of total knee prosthesis","Aseptic loosening","Total knee arthroplasty","Aseptic loosening of prosthetic joint","2025-02-17",{"date":504,"type":37},{"date":566,"type":21},"2025-02",{"date":568,"type":21},"2026-06",{"name":570,"class":44},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",7,{"id":573,"slug":574,"hasResults":12,"nctId":575,"briefTitle":576,"officialTitle":577,"acronym":4,"eligibilityCriteria":578,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":579,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":581,"conditions":582,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":585,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":590,"locationsCount":4},"100579923","physica-tt-tibial-plate-prospective-study-100579923","NCT06830603","Physica TT Tibial Plate Prospective Study","A Post Market, Prospective Clinical Study Evaluating Clinical and Radiographic Outcomes of Patients Undergoing Total Knee Arthroplasty with Physica TT Tibial Plate","Inclusion Criteria:\n\n1. Patient requiring a total knee arthroplasty (TKA) and suitable for receiving Physica TT Tibial Plate;\n2. Age ≥ 18 years old;\n3. Candidate for primary total knee replacement when clinical indications based on physical examination and medical history include one or more of the following conditions:\n\n   1. Non-inflammatory degenerative joint disease such as knee osteoarthritis, post traumatic knee arthritis;\n   2. Inflammatory degenerative joint disease such as rheumatoid arthritis;\n4. Patient has well-preserved and well-functioning collateral ligaments\n5. Patient is able to understand the conditions of the study, is willing and able to follow all prescribed rehabilitation as well as willing to perform all scheduled follow-up visits;\n6. Patient has signed the study-specific Informed Consent Form prior to study activities\n\nExclusion Criteria:\n\n1. Patient is affected by one or more of the conditions that are stated as Physica contraindications for use, which are:\n\n   * Severe instability of the knee joint secondary to the absence of collateral ligament integrity and\u002For function.\n   * Any active or suspected infection (local or systemic) or previous history of infection that may affect the prosthetic joint.\n   * Significant bone loss on femoral or tibial joint side.\n   * Known incompatibility or allergy to the product materials, and\u002For metal hypersensitivity to implant materials.\n   * Septicaemia.\n   * Persistent acute or chronic osteomyelitis.\n   * Open epiphyses (immature patient with active bone growth).\n   * Necrotic bone\n   * Arterial vascular insufficiency or nerve diseases of the lower limbs severe enough to interfere with the study evaluation.\n   * Compromised bone stock due to disease, infection or prior implantation that cannot provide adequate support and\u002For fixation to the prosthesis.\n   * Systemic or metabolic disorders leading to progressive bone deterioration, which may impair fixation and stability of the implant.\n   * Any concomitant disease and dependency that might affect the performance of the implanted prosthesis.\n   * Important osteoporosis, haemophilic disease.\n   * Internistic problems with high risk for surgery.\n2. Previous partial knee replacement (unicompartmental, bicompartmental or patellofemoral joint replacement), patellectomy, high tibial osteotomy.\n3. Affected by malignant cancer with life expectancy less than 2 years or where cancer treatment might affect the normal postoperative course.\n4. Any clinically major pathology based on clinical medical history or any medical intervention or reason that the Investigator feels may affect the study evaluation.\n5. Neurological or musculoskeletal disorder or disease that may adversely affect gait, functional recovery and evaluation.\n6. Neuromuscular or neurosensory deficit that would hamper the performance assessment of the device.\n7. Any psychiatric illness that would prevent comprehension of the details and nature of the study.\n8. Simultaneously taking part in another surgical intervention study or pain management study that may affect with clinical study outcomes.\n9. Female patient who is pregnant, nursing, or planning a pregnancy.",{"count":580,"type":21},142,"This prospective clinical study aims at evaluating clinical, radiographic, patient-reported outcomes of total knee arthroplasty with Physica TT Tibial Plate over 2 years after surgery, in order to assess the performance and safety of the devices. Short-term survivorship of the implant and the incidence of early complications are evaluated.",[27,583],"Knee Osteoarthritis","2025-02-11",{"date":563,"type":37},{"date":587,"type":21},"2025-05",{"date":589,"type":21},"2028-12",{"name":591,"class":592},"Limacorporate S.p.a","INDUSTRY",{"id":594,"slug":595,"hasResults":12,"nctId":596,"briefTitle":597,"officialTitle":598,"acronym":4,"eligibilityCriteria":599,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":600,"targetDuration":4,"studyType":22,"phases":602,"briefSummary":603,"conditions":604,"keywords":605,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":612,"lastUpdatePostDateStruct":613,"startDateStruct":615,"completionDateStruct":617,"leadSponsor":619,"locationsCount":45},"100576384","the-effect-of-tele-consultation-supported-education-after-total-knee-arthroplasty-surgery-100576384","NCT06784596","The Effect of Tele-Consultation Supported Education After Total Knee Arthroplasty Surgery","The Effect of Tele-Consultation Supported Education Based on Watson's Theory of Human Caring on Daily Living Activities, Quality of Life, and Self-Care Ability in Patients Undergoing Total Knee Arthroplasty","Inclusion Criteria:\n\n* Individuals who voluntarily consent to participate,\n* Aged 18 years or older,\n* Those scheduled for their first Total Knee Arthroplasty (TKA),\n* Patients undergoing unilateral knee prosthesis surgery,\n* Patients without verbal communication barriers for face-to-face and telephone interactions,\n* Patients who own a smartphone and have the WhatsApp application installed.\n\nExclusion Criteria:\n\n* Patients undergoing Total Knee Arthroplasty (TKA) as an emergency surgical intervention,\n* Patients diagnosed with any psychiatric disorder,\n* Patients who wish to withdraw from the study voluntarily,\n* Patients whose communication is interrupted before the completion of the data collection phase.",{"count":601,"type":21},122,[24],"Following total knee arthroplasty, patients may encounter numerous problems that can hinder the performance of daily living activities, negatively impact quality of life, and increase morbidity and mortality rates. In this context, this study was designed to evaluate the effect of nursing education and tele-consultation, based on Watson's Theory of Human Caring, on daily living activities, self-care agency, and quality of life in patients undergoing total knee arthroplasty.",[27],[606,607,608,609,610,611],"total knee replacement","education","teleconsulting","activities of daily living","self-care ability","quality of life","2025-01-17",{"date":614,"type":37},"2025-01-20",{"date":616,"type":21},"2025-03-01",{"date":618,"type":21},"2026-01-01",{"name":620,"class":44},"Turgut Sohret",{"id":622,"slug":623,"hasResults":12,"nctId":624,"briefTitle":625,"officialTitle":626,"acronym":4,"eligibilityCriteria":627,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":628,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":629,"conditions":630,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":631,"lastUpdatePostDateStruct":632,"startDateStruct":634,"completionDateStruct":636,"leadSponsor":638,"locationsCount":640},"100489437","a-post-market-domestic-us-and-international-data-collection-to-assess-the-truliant-knee-system-100489437","NCT05653102","A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System","CR17-003 Truliant Knee PMCF: A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System","Inclusion Criteria:\n\nCohort 1. Prospective \u002F Subjects- Enrolled in the study pre-surgery\n\n1. Subjects who agree to participate in the study that have not had surgery prior to being enrolled in the study.\n2. Skeletally mature (18 years of age or older).\n3. Subject is willing and able to provide written informed consent for participation in the study.\n4. Subject is to receive a Truliant® total knee replacement for Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Post-Traumatic Arthritis, Polyarthritis, Primary Implantation Failure, or as a Conversion of Uni-Compartmental Knee.\n5. The knee replacement will be performed by the investigator or a surgeon sub-investigator.\n6. The devices will be used according to the approved indications.\n\nCohort 2. Retrospective to Prospective \u002F Subjects enrolled in the study post- surgery then continue to participate in the study prospectively.\n\n1. Subjects who agree to participate in the study that have undergone surgery prior to enrollment in the study. Data for these subjects will collected from the subject's medical record for the time period prior to enrollment in the study containing data pertaining to the index surgery (retrospective data) and from the patient after they are enrolled in the study during the post-operative time period (prospectively).\n2. Skeletally mature (18 years of age or older).\n3. Subject is willing and able to provide written informed consent for participation in the study.\n4. Subject received a Truliant® total knee replacement for Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Post-Traumatic Arthritis, Polyarthritis, Primary Implantation Failure, or as a Conversion of Uni-Compartmental Knee.\n5. The knee replacement was performed by the investigator or a surgeon sub-investigator.\n6. The devices are\u002Fwere used according to the approved indications.\n\n   * Special consideration should be taken to ensure that these subjects meet all inclusion criteria, none of the exclusion criteria, and have a minimum of the following pre-operative, operative, and applicable postoperative data available in the subject's medical records, related to the Truliant® knee prosthesis manufactured or distributed by Exactech Inc (Gainesville, Florida, USA). Prior to inclusion in the study, the following details must be available for data submission: Pre-Operative:\n\n     o Demographic Data\n     1. Gender\n     2. Age at surgery\n     3. Height\u002FWeight\n     4. Indication for surgery\n     5. Prior Injuries\u002FSurgeries on index knee\n     6. Comorbidities\n   * Operative:\n\n     * Date of Surgery\n     * Type of Surgery (Primary \u002F Revision)\n     * All component product information, including catalogue reference numbers\n     * Adverse Event Information, if applicable\n\nCohort 3. Retrospective Only Subjects enrolled in the study post-study surgery with no intent to continue as prospective subjects. Note: No prospective data may be collected from a subject if they are enrolled under this cohort unless the subject is willing and able to provide written informed consent for participation in the study.\n\n1. Skeletally mature at the time of the surgery (18 years of age or older).\n2. The patient's clinical record includes a signed HIPAA waiver allowing for the use of clinical record data for the purpose of clinical research outside of the operating institution.\n3. The patients clinical record includes a documented procedure that includes, or is related to, TKA with a Truliant® Knee system device.\n4. The knee replacement was performed by the investigator or a surgeon sub-investigator.\n5. The devices are\u002Fwere used according to the approved indications.\n6. Special consideration should be taken to ensure that these subjects meet all inclusion criteria, none of the exclusion criteria and have a minimum of the following pre-operative, operative, and applicable postoperative data available in the subject's medical records, related to the Truliant® knee prosthesis manufactured or distributed by Exactech Inc (Gainesville, Florida, USA). Prior to inclusion in the study, the following details must be available for submission:\n\n   * Pre-Operative:\n\n     * Demographic Data\n     * Gender\n     * Age at surgery\n     * Height\u002FWeight\n     * Indication for surgery\n     * Prior Injuries\u002FSurgeries on index knee\n     * Comorbidities\n   * Operative:\n\n     * Date of Surgery\n     * Type of Surgery (Primary \u002F Revision)\n     * All component product information, including catalogue reference numbers Adverse Event Information, if applicable\n\nExclusion Criteria:\n\n* Patient was \\\u003C18 years of age at time of surgery\n* Patient does not meet indicated population for use criteria for this device\n* Patient is pregnant\n* Patient is a prisoner\n* Patient has a physical or mental condition that would invalidate the results\n* Patient is contraindicated for the surgery (e.g., metal allergy)",{"count":349,"type":21},"A Post-Market Domestic (US) and International Data Collection to Assess the Truliant® Knee System",[27],"2024-06-17",{"date":633,"type":37},"2024-06-18",{"date":635,"type":37},"2019-01-23",{"date":637,"type":21},"2035-07-31",{"name":639,"class":592},"Exactech",5,{"id":642,"slug":643,"hasResults":12,"nctId":644,"briefTitle":645,"officialTitle":646,"acronym":4,"eligibilityCriteria":647,"healthyVolunteers":81,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":648,"targetDuration":4,"studyType":22,"phases":650,"briefSummary":651,"conditions":652,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":631,"lastUpdatePostDateStruct":653,"startDateStruct":654,"completionDateStruct":656,"leadSponsor":658,"locationsCount":45},"100478930","evaluation-of-navigation-assisted-tka-using-mechanical-vs-restricted-kinematic-alignment-100478930","NCT05516381","Evaluation of Navigation-Assisted TKA Using Mechanical vs. Restricted Kinematic Alignment","Evaluation of Navigation-Assisted TKA Using Mechanical vs. Restricted Kinematic Alignment on Patient Reported Outcome Measures (PROMs): A Prospective, Randomized Clinical Study","Inclusion Criteria:\n\n* Subjects must meet all of the following inclusion criteria to be included in the study:\n\n  1. Subject must be at least 18 years of age at the time of the surgery (skeletally mature)\n  2. Subject will receive a Optetrak Logic® CR device per the \"Indications for Use\" described above\n  3. Subject must be willing to comply with the pre-operative and post-operative visit requirements\n  4. Subject must be willing and able to provide written informed consent for participation in the study\n\nExclusion Criteria:\n\n* Subjects will be excluded from the study if they meet any of the following exclusion criteria:\n\n  1. Subject with a suspected or confirmed systemic infection and\u002For a secondary remote infection\n  2. Subject without sufficient bone stock to allow appropriate insertion and fixation of the prosthesis\n  3. Subject without sufficient soft tissue integrity to provide adequate stability\n  4. Subject with either mental or neuromuscular disorders that do not allow control of the knee joint\n  5. Subjects whose weight, age, or activity level might cause extreme loads and early failure of the system\n  6. Subject is participating in another drug or device study other than knee replacement within the last three (3) months\n  7. Subject has behavioral and\u002For mental issues that may interfere with their ability to follow post-operative instructions\n  8. Subject is a prisoner\n  9. Subject is pregnant\n  10. Subject is undergoing radiation therapy where the targeted field involves the knee joint\n  11. Subjects with malignancy involving proximal tibia, distal femur, or knee joint\n  12. Subjects undergoing active administration of chemotherapy",{"count":649,"type":21},148,[24],"The purpose of this study is to evaluate both clinical measures and PROMs in patients undergoing total knee arthroplasty (TKA) using restricted inverse kinematic alignment (iKA) compared to mechanical alignment (MA), both using surgical navigation assistance.",[27],{"date":633,"type":37},{"date":655,"type":37},"2023-05-15",{"date":657,"type":21},"2027-06",{"name":639,"class":592}]