[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"knee-arthroscopy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:knee-arthroscopy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644703","phase-3-efficacy-of-intravenous-dexamethasone-in-prolonging-the-duration-of-spinal-anesthesia-with-chloroprocaine-in-knee-arthroscopy-100644703",false,"NCT07674576","Efficacy of Intravenous Dexamethasone in Prolonging the Duration of Spinal Anesthesia With Chloroprocaine in Knee Arthroscopy","Efficacy of Intravenous Dexamethasone in Prolonging the Duration of Spinal Anesthesia With Chloroprocaine in Knee Arthroscopy: a Double-blind, Randomized, Controlled Trial","CHLORODEX","Inclusion Criteria:\n\n* Undergoing knee arthroscopy lasting ≤ 40 minutes requiring spinal anesthesia (diagnostic arthroscopy or meniscal surgery),\n* Signed written informed consent form,\n* Affiliation to a social security system,\n* Negative pregnancy test on the day of procedure for non-menopausal patients.\n\nExclusion Criteria:\n\n* Contraindications to spinal anesthesia with intrathecal chloroprocaine\n* History of diabetes,\n* Pre-existing peripheral neuropathy,\n* American Society of Anesthesiologists (ASA) physical status IV,\n* Contraindication to dexamethasone,\n* Hypersensitivity of any drug used in this study,\n* Long-term oral corticosteroid therapy,\n* Chronic opioid use,\n* Chronic pain syndromes,\n* Contraindications to Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) (Ketoprofen, Celecoxib)\n* Need for a peripheral nerve block in addition to spinal anesthesia (e.g. knee ligamentoplasty),\n* Mental or linguistic inability to understand the study,\n* Patients under legal protection (guardianship, curatorship or safeguard of justice),\n* Patients currently included or planning to be included in another interventional study,\n* Pregnant or breastfeeding women,\n* Women of childbearing potential not using effective contraception.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","Chloroprocaine is a short-acting local anesthetic that allows rapid recovery and early ambulation but is currently recommended for procedures lasting 40 minutes or less.\n\nDexamethasone is commonly used during anesthesia for the prevention of postoperative nausea and vomiting and has also been shown to prolong the duration of analgesia and sensory block after regional anesthesia.\n\nDexamethasone may therefore extend the duration of chloroprocaine spinal anesthesia, potentially allowing its use for longer surgical procedures while maintaining the benefits of rapid postoperative recovery.\n\nThis study aims to evaluate whether intravenous dexamethasone can prolong the effects of spinal anesthesia performed with chloroprocaine in adults undergoing knee arthroscopy.",[27],"Knee Arthroscopy",[29,30,31,32,33,34],"Knee arthroscopy","dexamethasone","chloroprocaine","spinal anesthesia","sensory block","motor block","NOT_YET_RECRUITING","2026-06-25",{"date":38,"type":39},"2026-06-29","ACTUAL",{"date":41,"type":21},"2026-09-01",{"date":43,"type":21},"2028-09-01",{"name":45,"class":46},"CMC Ambroise Paré","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":47},"100597938","phase-4-effects-of-intraarticular-tramadol-and-tramadol-dexamethasone-on-postoperative-pain-after-knee-arthroscopy-100597938","NCT07064993","Effects of Intraarticular Tramadol and Tramadol-Dexamethasone on Postoperative Pain After Knee Arthroscopy","A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Evaluating the Effects of Intraarticular Tramadol and Tramadol Plus Dexamethasone on Postoperative Pain After Knee Arthroscopy","KATD-PAIN","Inclusion Criteria:\n\nPatients aged 18-65 years ASA physical status I-II Scheduled for elective knee arthroscopy under general anesthesia Only minor arthroscopic procedures such as partial meniscectomy will be included Ability to provide informed consent\n\nExclusion Criteria:\n\nAllergy or contraindication to tramadol or dexamethasone Chronic opioid use or chronic pain conditions History of psychiatric or neurological disorders that may affect pain perception Severe hepatic or renal impairment Pregnancy or breastfeeding Infection at the injection site Bleeding diathesis Refusal to participate Major reconstructive knee surgeries (e.g., anterior cruciate ligament reconstruction)","65 Years",{"count":58,"type":21},135,[60],"PHASE4","Patients scheduled for elective knee arthroscopy under general anesthesia will be randomly assigned into three groups in a 1:1:1 ratio: placebo (saline), tramadol, and tramadol plus dexamethasone. At the end of surgery, after aspiration of the irrigation fluid, the study solution will be administered intraarticularly in a standardized volume.\n\nThe primary outcome is the area under the curve (AUC) of VAS scores measured at 0, 2, 6, 12, and 24 hours postoperatively (VAS AUC 0-24h). Secondary outcomes include time to first analgesic requirement, total analgesic consumption within 24 hours, and the incidence of adverse effects such as nausea, vomiting, itching, and shivering.\n\nThis study aims to determine whether intraarticular tramadol provides effective postoperative analgesia and whether the addition of dexamethasone enhances this analgesic effect.",[27,63],"Postoperative Pain",[27,63,65,66,67,68,69],"Intraarticular Injection","Tramadol","Dexamethasone","Analgesia","Randomized Controlled Trial","2026-05-11",{"date":72,"type":39},"2026-05-14",{"date":74,"type":21},"2026-07-15",{"date":76,"type":21},"2027-04-30",{"name":78,"class":46},"Arzu Esen Tekeli",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":47},"100614166","outpatient-total-knee-arthroscopy-tka-comparison-of-postoperative-recovery-versus-a-conventional-hospitalization-100614166","NCT07276061","Outpatient Total Knee Arthroscopy (TKA): Comparison of Postoperative Recovery Versus a Conventional Hospitalization","Outpatient Total Knee Prosthesis, Comparison of Postoperative Recovery Versus Conventional Hospitalization: a Retrospective, Single-center, Observational, Comparative Study of Superiority","PTG","Inclusion Criteria:\n\n* Male or female, 18 years of age or older (no upper age limit)\n* Undergoing scheduled unilateral total knee replacement surgery between January 1, 2020 and June 30, 2023 at the Strasbourg University Hospitals\n* Assessed using the QoR-15F score\n\nExclusion Criteria:\n\n* Subject who has expressed opposition to the reuse of their data for scientific research purposes.\n* Revision, emergency, oncological, bilateral, or septic surgery.",{"count":88,"type":21},440,"OBSERVATIONAL","Outpatient TKA is a controversial topic due to concerns about its safety as an outpatient procedure, and remains a marginal procedure. Advances in enhanced postoperative rehabilitation protocols, coupled with advances in minimally invasive surgery, have made it possible to operate on an increasing number of patients on an outpatient basis. However, there are no studies in the literature analyzing functional recovery after outpatient TKA in France. The objective of this study was to compare postoperative recovery, assessed by the QoR-15F score, in patients undergoing outpatient TKA compared to those undergoing a conventional hospitalization.",[27],[93],"knee arthroscopy","RECRUITING","2025-12-08",{"date":97,"type":39},"2025-12-10",{"date":99,"type":39},"2024-03-11",{"date":101,"type":21},"2025-12-31",{"name":103,"class":46},"University Hospital, Strasbourg, France"]