[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"knee-discomfort\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:knee-discomfort":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,79,106,128],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100420286","compliance-with-proms-detection-through-digital-support-and-correlation-compared-standard-to-outpatient-detection-in-knee-prosthetics-100420286",false,"NCT04752761","Compliance With PROMs Detection Through Digital Support and Correlation Compared Standard to Outpatient Detection in Knee Prosthetics","Compliance al Rilevamento PROMs Mediante Supporto Digitale e Correlazione Rispetto Alla Rilevazione Ambulatoriale Nella Protesica di Ginocchio","DIG-PROMs-k","Inclusion Criteria:\n\n* patients with gonarthrosis with indication of hip arthroplasty\n* males and females aged 18-78 and with a Barthel scale score ≥ 91\n* patients in possession of private digital electronic support (smartphone, tablet or PC)\n\nExclusion criteria:\n\n* patients with a Barthel scale score ≤ 90\n* patients with psychiatric pathologies, a history of drug and alcohol abuse\n* patients not in possession of private digital electronic support","ALL","18 Years","78 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","Two methods for detecting outcomes after knee prosthetic surgery are compared: the traditional one using paper questionnaires administered in the outpatient setting (Oxford Knee Score) VS detection using digital questionnaires created on Google Forms and sent to the patient's smartphone on which the compilation takes place in the extra area outpatient.",[28,29],"Approach-Approach Conflict","Knee Discomfort",[31,32,33,34],"PROMs","Digital","Knee prosthesis","Oxford knee score","RECRUITING","2026-05-21",{"date":38,"type":39},"2026-05-26","ACTUAL",{"date":41,"type":39},"2020-11-30",{"date":43,"type":22},"2027-12-31",{"name":45,"class":46},"Istituto Ortopedico Rizzoli","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100537405","exercise-in-patients-with-hypermobile-joints-and-knee-pain-100537405","NCT06277401","Exercise in Patients With Hypermobile Joints and Knee Pain","High-load Resistance Training Compared With Usual Care for Treatment of Painful Knee Joint Hypermobility in Young Adults: A Randomised Controlled Trial (the HIPEr-Knee Study)","HIPEr-Knee","Inclusion criteria\n\n* Persistent knee pain for ≥ 3 months (self-reported)\n* Knee pain ≥ 30mm during the last week using a 0-100 mm visual analogue scale (VAS; 0=no pain and 100=worst imaginable pain) (self-reported)\n* Generalised joint hypermobility assessed with the Five-Part Hypermobility Questionnaire (positive ≥ 2\u002F5) (self-reported)\n* Local knee joint hypermobility using the passive hyperextension of the knee in standing (positive \\> 10 degrees of hyperextension) and confirmed in supine lying (heel resting on 20 cm high block on the bench surface), with passive knee hyperextension (positive \\> 10 degrees) (objectively measured)\n\nExclusion criteria\n\n* Diagnosed with patellar tendinopathy\n* Pregnancy or childbirth within the past year (due to increased levels of relaxin that could affect joint stability)\n* Knee surgery within the past year\n* Participation in regular structured resistance training within the past six months\n* Inability to speak and understand Danish.\n* All types of Ehlers-Danlos syndrome\n* Other heritable connective tissue disorders such as Marfan syndrome, osteogenesis imperfecta, Loeys-Dietz syndrome, Stickler syndrome, skeletal dysplasias\n* Autoimmune rheumatic connective tissue disorders such as lupus, rheumatoid arthritis; Chromosomal conditions such as Fragile X syndrome, Kabuki syndrome, Down syndrome\n* Neuromuscular disorders that can cause joints to become unstable, such as multiple sclerosis","45 Years",{"count":58,"type":22},90,[25],"Pain associated with knee joint hypermobility is common in the adult population, but evidence on treatment is sparse. This study investigates if high-load resistance training is superior to usual care in improving activity-related pain in young patients (18-45 years) with hypermobile joints and knee pain.",[62,63,29],"Hypermobility, Joint","Hypermobility Syndrome",[65,66,67,68],"Hypermobility","Knee pain","Treatment","Randomised controlled trial","2026-04-28",{"date":71,"type":39},"2026-04-29",{"date":73,"type":39},"2024-02-21",{"date":75,"type":22},"2027-12",{"name":77,"class":46},"University of Southern Denmark",2,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":85,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":94,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":47},"100630989","images-identifying-metabolic-imaging-association-with-genicular-artery-embolization-success-100630989","NCT07494838","IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success","Inclusion Criteria:\n\n* Provided informed consent\n* Age ≥ 40 years\n* Ineligibility for or refusal of surgical management\n* Moderate-severe knee pain as determined by visual analog scale \\> 5 out of 10\n* Osteoarthritis based on X-ray. Kellgren-Lawrence score \\> 2 based on radiograph completed within 3 months of procedure date\n* Resistant\u002Ffailed some form of conservative treatment (e.g. NSAIDS\u002Fphysical therapy\u002Fsteroid joint injection\u002Fhyaluronic acid joint injection) for at least 3 months\n* Able to comply with all treatments and protocol follow-up visits\n\nExclusion Criteria:\n\n* Mild knee pain as determined by visual analog scale \\\u003C 5 out of 10\n* OA on knee radiograph resulting in greater than 20 degree varus or valgus angulation\n* Moderate loss of kidney function, define as estimated glomerular filtration rate of less than 45 mL\u002Fmin.\n* Significant arterial atherosclerosis that would limit selective angiography\n* History of fibromyalgia, autoimmune, or inflammatory disorder\n* History of any lumbar spine surgery, spine injections, or radicular pain in the extremity believed to originate from the spine\n* Allergy to iodinated contrast agents\n* Active infection or malignancy\n* Recent (within 12 months) or active cigarette use\n* Prior total or partial knee replacement in the subject knee\n* Active pregnancy\n* Uncorrectable bleeding diathesis\n* Presence of pacemakers, aneurysm clips, neurostimulators, or any other metal implant not compatible with PET\u002FMRI","40 Years",{"count":87,"type":22},25,[25],"Several clinical trials on genicular artery embolization (GAE) show significant clinical benefit for the majority of patients. However, a proportion of patients do not benefit from GAE, and responses vary across individual patients. Changes in metabolic activity on non-invasive imaging may correlate with improvement in symptoms of knee osteoarthritis. This study will assess changes in metabolic uptake on a hybrid positron emission tomography\u002Fmagnetic resonance imaging (PET\u002FMRI) system in subjects undergoing GAE.",[91,29,92,93],"Knee Osteoarthritis","Knee Pain Chronic","Knee Swelling Pain",[95],"GAE","NOT_YET_RECRUITING","2026-03-21",{"date":99,"type":39},"2026-03-27",{"date":101,"type":22},"2026-06-30",{"date":103,"type":22},"2027-06-30",{"name":105,"class":46},"Lucas R. Cusumano, MD",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":112,"sex":17,"minAge":113,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":47},"100559876","evaluation-study-for-the-jockey-club-e-generation-impact-extension-project-for-chronic-knee-pain-management-100559876","NCT06569836","Evaluation Study for the \"Jockey Club E-Generation: Impact Extension Project for Chronic Knee Pain Management\"","Inclusion Criteria:\n\ni. Aged ≥55 years;\n\nii. Community-dwelling;\n\niii. With self-reported knee pain problem currently or in the past 12 months;\n\niv. Cognitively sound (screened by the Clock Drawing Test (CDT) ≤ 4 (Agrell \\& Dehlin, 1998));\n\nv. Able to understand and communicate in Cantonese or Mandarin.\n\nExclusion Criteria:\n\ni. Diagnosed with stroke, myocardial infarction, injury or inflammation of the knee, autoimmune disease, unable to walk in the past three months;\n\nii. Users\u002F of Hospital Authority medical consultation or physiotherapy or occupational therapy services related to osteoarthritis knee;\n\niii. Screened to have three or above conditions including significant knee symptom score 5 or above, WOMAC Score ≥48, 5 times Sit to Stand test \\>16.7 seconds, Time Up and Go Test \\>14 seconds, Age \\>80 and BMI \\>25.",true,"55 Years",{"count":115,"type":22},858,[25],"Objectives:\n\nThis study aims to evaluate the effectiveness of the \"Jockey Club E-Generation: Impact Extension Project for Chronic Knee Pain Management\", with a view to developing sustainable strategies of self-management on chronic conditions integrating with tele-rehabilitation technology.\n\nStudy design and participants:\n\nAn evaluation study adopting a randomized controlled trial design, with waitlist attention control will be conducted in Elderly community centres of Hong Kong Sheng Kung Hui Welfare Council and Christian Family Service Centre (CFSC) in Hong Kong. The proposed sample size is 858 participants, which is a convenience sample from the service user of the \"Jockey Club E-Generation: Impact Extension Project for Chronic Knee Pain Management\". At least 15 participants will be invited for qualitative interview.\n\nParticipants will be randomized to the intervention group or the waitlist attention control group in 1:1 ratio using block randomization with random block size of 4, 6 and 8, stratified by each centre and severity of condition. A researcher independent to the project will generate the randomization sequence by computer and keep the list. Participants in the intervention group (known as Group A to the participants) will start the 12-week intervention immediately, whereas the waitlist attention control (know as Group B to the participants) will start the intervention after 12 weeks. During the waiting period, waitlist control receives attention control.\n\nMeasurements:\n\nThe primary outcome of this study is quality of life. It will be measured by the Hong Kong Chinese version of World Health Organization Quality-of-Life Scale (WHOQOL-BREF).\n\nThe secondary outcomes are pain, physical functioning, emotional functioning, adherence rate, satisfaction score, rate of adverse events in relation to the intervention, and cost-effectiveness of the intervention.\n\nExpected results:\n\nThe improvement in health-related quality of life of older adults is larger in the intervention group as compared to the control group; The relief in knee pain of older adults is larger in the intervention group as compared to the control group; The improvement in physical functioning of older adults is larger in the intervention group as compared to the control group; The improvement in emotional functioning of older adults is larger in the intervention group as compared to the control group.",[29,92],"2024-12-03",{"date":121,"type":39},"2024-12-05",{"date":123,"type":39},"2024-08-19",{"date":125,"type":22},"2026-09-30",{"name":127,"class":46},"The University of Hong Kong",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":135,"enrollmentInfo":136,"targetDuration":4,"studyType":23,"phases":138,"briefSummary":139,"conditions":140,"keywords":146,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":163,"locationsCount":47},"100502624","depuy-synthes-variable-angle-lcp-patella-plating-system-study-100502624","NCT05824676","DePuy Synthes Variable Angle LCP Patella Plating System Study","Utility of the Variable Angle LCP Patella Plating System for Traumatic Patellar Fractures: A Randomized Control Trial","Inclusion Criteria:\n\n* Males and females\n* Age between 18 and 74 years old (inclusive)\n* Patellar fracture\n* Treated at Hartford HealthCare The Bone and Joint Institute or Hartford Hospital\n\nExclusion Criteria:\n\n* Age greater than or equal to 75 or less than 18\n* Patients that are non-ambulatory\u002Flimited ambulation prior to their injury\n* Previous patellar fracture\n* Pre-existing osteoarthritis of the knee\n* Ipsilateral femoral or tibia fractures","74 Years",{"count":137,"type":22},36,[25],"The Depuy Synthes Locking Compression Plate (LCP) Variable Angle Patella Plating System is an FDA approved device. The purpose of this study is to see how well the Depuy Synthes LCP Variable Plating System work in fixing a broken kneecap (patella). Depuy says that the device will improve healing when compared to traditional ways of repairing a broken patella.\n\nThe goal of this randomized control trial is to learn how well the LCP Variable Plating System works to fix a broken patella (kneecap) compared to traditional fixation methods, in male and females, age 18 to 74, with a patellar fracture, and being treated at Hartford HealthCare The Bone and Joint Institute or Hartford Hospital. The main question it aims to answer are:\n\n* To understand if the Depuy Synthes LCP Variable Angle Plating System will provide a better way to help patients recover from a broken patella.\n\nParticipants will evaluated at specific time points: post-op day 1, 6 weeks, 3 months, 6 months, and 12 month post-surgery. Participants will be asked to:\n\n* Complete surveys at all evaluation timepoints.\n* Have x-rays(radiographs) taken at the 6 week, 3 month, 6 month, 9 month, and 1 year timepoints.\n* Participants will have a passive range of motion tests done at 6 week, 3 month, 6 month, 9 month, and 1 year timepoints.\n* Participants would have strength and balance tests done at the 3 month, 6 month, 9 month, and 1 year timepoints.",[141,142,143,144,29,145],"Trauma","Patella Fracture","Knee Cap","Knee Cap Injury","Knee Deformity",[147,148,149,150,151,152,153,154,155,156],"Patella","Plating","trauma","kneecap","injury","knee injuries","knee injury","fracture","break","randomized","2023-04-10",{"date":159,"type":39},"2023-04-21",{"date":161,"type":22},"2023-05",{"date":75,"type":22},{"name":164,"class":46},"Hartford Hospital"]