[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"knee-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:knee-injuries":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,23,0,[8,49,75,112,139,157,183,207,234,257,279,316,340,362,392,416,443,466,491,508,531,564,586],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100504462","gait-rehabilitation-to-treat-fastoa-100504462",false,"NCT05848622","Gait Rehabilitation to Treat FastOA","Inclusion Criteria:\n\n* Have completed all other formal physical therapy\n* Are between the ages of 16 and 35\n* Underwent an anterior cruciate ligament reconstruction (ACLR) between 6 and 60 months prior to enrollment\n* Demonstrate underloading during gait (vGRF- impact peak \\\u003C1.12 x BW)\n\nExclusion Criteria:\n\n* A multiple ligament surgery (i.e., PCL)\n* A lower extremity fracture (i.e., displaced tibial plateau fracture)\n* Knee osteoarthritis","ALL","16 Years","35 Years",{"count":19,"type":20},70,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to determine the effects of real-time gait biofeedback delivered over a 6-week period on early markers of FastOA and conduct 6-week and 6-month follow-up assessments in anterior cruciate ligament reconstructed patients.",[26,27,28,29,30,31,32],"Anterior Cruciate Ligament Injuries","Post-traumatic Osteoarthritis","Knee Osteoarthritis","Osteo Arthritis Knee","Knee Injuries","Cartilage, Articular","Gait",[34,35],"Biofeedback","FastOA","RECRUITING","2026-06-24",{"date":39,"type":40},"2026-06-25","ACTUAL",{"date":42,"type":40},"2023-06-13",{"date":44,"type":20},"2027-06",{"name":46,"class":47},"University of North Carolina, Chapel Hill","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":48},"100351621","phase-4-opioids-versus-non-opioids-postoperative-after-knee-arthroscopic-surgery-100351621","NCT03858231","Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery","The Effects of Combination Therapy of Opioids Versus Non-Opioids on Postoperative Pain Management After Knee Arthroscopic Surgery: A Prospective Randomized Controlled Study","Inclusion Criteria:\n\n1. Subjects ≥ 18 years of age through ≤ 80 years of age\n2. Subjects undergoing elective arthroscopic knee surgery, to include partial meniscectomy, chondroplasty, or loose body removal.\n\nExclusion Criteria:\n\n1. Previously enrolled in this study (enrolled for contralateral knee in this study)\n2. Knee arthroscopy patients scheduled for knee ligament reconstructions\n3. Bilateral knee arthroscopy\n4. History of chronic opioid use or long-term analgesic therapy\n5. Documented or suspected substance abuse\n6. Documented or suspected chronic pain syndrome\n7. Any known allergy or adverse reaction or contraindication to the components of hydrocodone, acetaminophen, or ibuprofen\n8. History or symptoms of any significant medical problem in the last year (i.e., arrhythmia, impaired cardiovascular function, gastrointestinal bleeding, liver disease, renal disease)\n9. With active peptic ulcer disease (history of severe heartburn)\n10. Symptoms of infection with initial enrollment\n11. Pregnant or nursing\n12. Diagnosis of cognitive impairment\n13. Unable or unwilling to provide informed consent for surgery or enrollment in this clinical study\n14. Inability to understand the requirements of the study or be unwilling to provide written informed consent (as evidenced by signature on an informed consent document approved by Institutional Review Board) and agree to abide by the study restrictions.\n15. Patient refusal\n16. Currently taking Coumadin, Plavix, anticoagulation medications, or medications that increase bleeding, with the exception of ASA 81mg.\n17. Patients with other medical or psychological health conditions that preclude them from either receiving the intervention or returning for follow-up visits.\n18. Alcoholism","18 Years","80 Years",{"count":59,"type":20},148,[61],"PHASE4","The purpose of this study is to look at pain management with opioids versus non-opioids after knee arthroscopy. This study will determine 1) whether the most commonly used non-narcotic medications provide pain relief comparable with the most commonly prescribed narcotic medications in patients undergoing arthroscopic knee surgery, and 2) whether patients' characteristics (gender, pre-operative knee symptoms, workers compensation status and employment status) affect pain level following surgery or medication usage.",[30,64,65],"Pain, Postoperative","Opioid Use","2026-02-07",{"date":68,"type":40},"2026-02-10",{"date":70,"type":40},"2018-10-29",{"date":72,"type":20},"2028-01",{"name":74,"class":47},"Sanford Health",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":56,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":48},"100624198","identification-of-kinematic-variables-specific-of-patellar-tendinopathy-in-athletes-at-risk-100624198","NCT07406516","Identification of Kinematic Variables Specific of Patellar Tendinopathy in Athletes at Risk","TENVOL","* Subject aged between 18 and 45 years\n* Male subject\n* Regularly participating in physical activity involving jumping (a predisposing factor for patellar tendinopathy) twice a week for at least one year.\n* Participants affiliated with or covered by a social security scheme\n\nSPECIFIC INCLUSION CRITERIA FOR THE PATELLAR TENDINOPATHY GROUP\n\nPatients with at least 2 of the following 3 criteria:\n\n* Modified Öhberg score ≥2 according to L Öhberg, H Alfredson (2002)\n* VISA-PF \\\u003C 80\u002F100 according to Kaux et al. (2016) and\u002For OSTRC P ≥ 6\u002F100 according to Owoeye et al. (2018)\n* Single Leg Decline Squat (SLDS): VAS ≥ 1\u002F10 with pain mapping at the patellar tendon; according to Coombes et al. (2020)\n\nSPECIFIC INCLUSION CRITERIA FOR THE HEALTHY GROUP\n\nPatients with 0 or 1 of the following 3 criteria:\n\n* Modified Öhberg score ≥2 according to L Öhberg, H Alfredson (2002)\n* VISA-PF \\\u003C 80\u002F100 according to Kaux et al. (2016) and\u002For OSTRC P ≥ 6\u002F100 according to Owoeye et al. (2018)\n* Single Leg Decline Squat (SLDS): VAS ≥ 1\u002F10 with pain mapping at the patellar tendon; according to Coombes et al. (2020)\n\nNon inclusion Criteria:\n\n* Significant medical and surgical history involving the lower limbs (e.g., ACL ligament reconstruction, meniscectomy, etc.)\n* Contraindications to participating in sports activities\n* Other pathologies involving the lower limbs (\\\u003C 6 months), e.g., torn knee ligaments, ankle sprain, knee sprain, etc.\n* Participants who have not given their informed consent\n* Participants subject to legal protection measures (legal guardianship, conservatorship, curatorship)\n* Participants deprived of their liberty by judicial or administrative decision",true,"MALE","45 Years",{"count":86,"type":20},60,[23],"This research aims to identify and monitor specific kinematic markers associated with patellar tendinopathy in athletes at risk. Using a markerless motion capture system, vertical jump tests will be analyzed to detect early biomechanical changes in the knees, hips, trunk, and ankles. By comparing injured participants, the study seeks to improve early diagnosis and personalized prevention strategies for patellar tendinopathy.",[90,91,92,30],"Patellar Tendinitis","Jumper's Knee","Musculoskeletal Injuries",[94,95,96,97,98,99,100,101],"patellar tendinopathy","injury","Jumper's knee","Biomechanical variables","Biomechanical modeling","Measurement in an ecological environment","Profiling","Markerless technology","NOT_YET_RECRUITING","2026-02-05",{"date":105,"type":40},"2026-02-12",{"date":107,"type":20},"2026-05-01",{"date":109,"type":20},"2029-05-01",{"name":111,"class":47},"University Hospital, Montpellier",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":122,"conditions":123,"keywords":124,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":48},"100559984","validity-and-reliability-of-the-turkish-version-of-the-tegner-activity-score-100559984","NCT06571240","Validity and Reliability of the Turkish Version of the Tegner Activity Score","The Turkish Version of the Tegner Activity Score: Cultural Adaptation, Validity, and Reliability","Inclusion Criteria:\n\n* to be over 18 years old\n* to undergo surgery for a ruptured anterior cruciate ligament\n\nExclusion Criteria:\n\n* to have metabolic or autoimmune diseases\n* to undergo revision anterior cruciate ligament surgery or anterior cruciate ligament repair\n* to have cognitive issues that will hinder the completion of the study forms\n* to lack sufficient proficiency in Turkish",{"count":120,"type":20},69,"OBSERVATIONAL","The goal of this observational study is to learn about patients who will undergo anterior cruciate ligament reconstruction. The main questions it aims to answer are:\n\n* Is the Turkish version of the Tegner Activity Score a valid scale?\n* Is the Turkish version of the Tegner Activity Score a reliable scale?\n* What is the minimal clinically important difference value of the Turkish version of the Tegner Activity Score?\n* What is the substantial clinical benefit value of the Turkish version of the Tegner Activity Score?",[30],[125,126,127,128,129],"Tegner activity score","Anterior cruciate ligament injury","Validity","Reliability","Patient reported outcome","2026-01-28",{"date":132,"type":40},"2026-01-30",{"date":134,"type":40},"2025-01-06",{"date":136,"type":20},"2027-04",{"name":138,"class":47},"Kırklareli University",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":146,"conditions":147,"keywords":148,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":153,"startDateStruct":154,"completionDateStruct":155,"leadSponsor":156,"locationsCount":48},"100559983","establishing-the-clinical-significance-values-of-the-lysholm-knee-score-100559983","NCT06571227","Establishing the Clinical Significance Values of the Lysholm Knee Score","Establishing the Clinical Significance Values of the Lysholm Knee Score in Patients Undergoing Anterior Cruciate Ligament Reconstruction",{"count":120,"type":20},"The goal of this observational study is to learn about patients who will undergo anterior cruciate ligament reconstruction. The main questions it aims to answer are:\n\n* What is the minimal clinically important difference value of the Lysholm Knee Score?\n* What is the substantial clinical benefit value of the Lysholm Knee Score?\n* What are the risk factors that prevent patients who have undergone anterior cruciate ligament reconstruction from reaching the minimal clinically important difference value?\n* What are the risk factors that prevent patients who have undergone anterior cruciate ligament reconstruction from reaching the substantial clinical benefit value?",[30],[149,126,150,151,152,129],"Lsholm knee score","Minimal important change","Substantial clinical benefit","Clinical significance",{"date":132,"type":40},{"date":134,"type":40},{"date":136,"type":20},{"name":138,"class":47},{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":15,"minAge":163,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":21,"phases":167,"briefSummary":168,"conditions":169,"keywords":170,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":48},"100575274","comparison-between-the-use-of-the-tensioner-and-standard-surgical-technique-for-ligament-balancing-of-total-knee-prostheses-100575274","NCT06770153","Comparison Between the Use of the Tensioner and Standard Surgical Technique for Ligament Balancing of Total Knee Prostheses","Inclusion Criteria:\n\n* Male and female subjects candidates for primary cemented total knee prosthesis model Attune PS mobile plate DePuy.\n* Patients who possess all the psychophysical capabilities to be able to undergo the operation and all the check-ups with radiological tests included (e.g. all patients who are not willing to go to the institute for all the scheduled follow-up visits will be excluded) .\n* Patients who have signed the \"informed consent\" approved by the Ethics Committee.\n* Patients who are aged between 50-85.\n\nExclusion Criteria:\n\n* Social conditions that prevent participation in the study in all its phases (homeless patients, with restrictions on personal freedom, etc.)\n* Patients suffering from deep venous insufficiency of the lower extremities or with a personal or family history of deep venous thrombosis or pulmonary embolism\n* Patients with a history of erysipelas in the lower extremities\n* Patients suffering from neurological or psycho-cognitive disorders\n* Patients suffering from post-traumatic arthrosis\n* Patients who have already undergone prosthetic surgery and\u002For arthrodesis at the level of a lower limb joint\n* Patients with axial knee deformities \\>15°\n* Pregnant female patients\n* Patients with rheumatic diseases","50 Years","85 Years",{"count":166,"type":20},200,[23],"the objective of the present study is to compare the post-operative laxity using stress radiographs and clinical scores in two groups of patients undergoing primary PS TKA with identical prosthetic model performed in two specialized centers, of which one group implanted with standard technique and one group through the intraoperative use of the tensioner",[30],[171,172,173],"Knee prosthesis","prosthesis","knee","2026-01-22",{"date":176,"type":40},"2026-01-26",{"date":178,"type":40},"2024-10-11",{"date":180,"type":20},"2026-10",{"name":182,"class":47},"Istituto Ortopedico Rizzoli",{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":4,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":4,"enrollmentInfo":190,"targetDuration":4,"studyType":21,"phases":192,"briefSummary":193,"conditions":194,"keywords":196,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":48},"100370921","pulsed-electromagnetic-field-pemf-therapy-for-post-operative-pain-following-orthopedic-surgery-100370921","NCT04109638","Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery","A Pilot Prospective, Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Pulsed Electromagnetic Field (PEMF) Therapy in Decreasing Post-Operative Pain Following Orthopedic Surgery","Inclusion Criteria:\n\n1. Subjects may be male or female greater or equal to 18 years of age (≥ 18) at the time of consent.\n2. Subjects who will be having shoulder or knee surgery are permitted.\n3. Subject must not have used NSAIDs for one (1) week prior to surgery.\n\n   a. a. Low-dose aspirin (81 mg) is permitted.\n4. Subject must be willing and able to participate in post-operative physical therapy exercises.\n5. Subject must understand and be willing to sign the IRB-approved Informed Consent Document.\n\nExclusion Criteria:\n\n1. Subject has a known collagen disorder such as, but not limited to, osteogenesis imperfecta (OI) or Ehlers-Danlos syndrome (EDS).\n2. Subject has a known inflammatory or autoimmune connective tissue disease such as, but not limited to, gout affecting the shoulder, scleroderma, SLE, rheumatoid disease, or calcific tendonitis of the shoulder.\n3. Subject has a metabolic bone disease such as Paget's disease or osteomalacia as documented in the medical record.\n4. Subject has a deltoid defect, deltoid palsy or any other pseudoparalysis.\n5. Subject is diabetic.\n6. Subject has HIV or hepatitis.\n7. Subject has a diagnosis of fibromyalgia or other chronic pain syndrome.\n8. Subject has shoulder or knee pain of unknown etiology.\n9. Subject has had an active malignancy in the past 5 years OR has an active or on-going neoplastic disease, except for benign skin cancer(s).\n10. Subject has undergone administration, within 30 days prior to surgery, of any type of corticosteroid (with the exception of asthma medications and ophthalmic medications), antineoplastic, immunostimulation or immunosuppressive agent.\n11. Subject is septic, or has a local or systemic infection.\n12. Subject has an admitted active substance abuse problem which includes recreational drugs and\u002For narcotics or a history of substance abuse where history is defined as \"not under the care of a physician\" for more than 5 years.\n\n    a. Prescriptive medical marijuana is not permitted, including CBD oils.\n13. Subject consumes more than 14 (men) or 7 (women) standard drinks (alcoholic units) per week where a drink equals a 12 oz. beer, or a 5 oz. glass of wine, or a 1.5 oz. shot of liquor.\n14. Subject is currently seeking or receiving worker's compensation for this injury or for an injury that has occurred more than 12 months prior to enrollment in this study or subjects who are currently in litigation or who have a history of litigation related to musculoskeletal diagnoses.\n15. Subject has major mental illnesses including major depression, bipolar disorder, schizophrenia or dementia that would prevent them from following the protocol and\u002For independently completing the patient reported outcomes measures.\n16. Subjects who have coexistent cervical spinal pathologies such as radiculopathies or myelopathies.\n17. Subject has a mental or physical condition that would prevent them from complying with the study protocol.",{"count":191,"type":20},76,[23],"The primary objective of this study is to prospectively determine, at 10 days after orthopedic shoulder or knee surgery, if pulsed electromagnetic field (PEMF) therapy is beneficial in reducing patient-reported post-operative pain, as measured by visual analog scale (VAS). The amount of pain medication taken daily and the physical function outcome scores after surgery and PEMF treatment will also be measured.",[30,195,64],"Shoulder Injuries",[197],"PEMF","2026-01-20",{"date":200,"type":40},"2026-01-21",{"date":202,"type":40},"2021-02-01",{"date":204,"type":20},"2027-02",{"name":206,"class":47},"Stanford University",{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":83,"minAge":56,"maxAge":213,"enrollmentInfo":214,"targetDuration":4,"studyType":21,"phases":216,"briefSummary":217,"conditions":218,"keywords":4,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":48},"100617154","the-effects-of-neuromuscular-training-on-knee-biomechanics-during-jump-landing-among-college-basketball-players-post-acl-reconstruction-and-rehabilitation-100617154","NCT07314931","The Effects of Neuromuscular Training on Knee Biomechanics During Jump-Landing Among College Basketball Players Post ACL Reconstruction and Rehabilitation","Inclusion Criteria:Male college basketball players\n\nAge 18-25 years\n\nHistory of anterior cruciate ligament (ACL) reconstruction surgery at least 12 months before enrollment\n\nCleared by physician for sports participation\n\nWilling to provide informed consent and comply with study procedures\n\nExclusion Criteria:Previous ACL injury on the contralateral knee\n\nOther major lower-limb injuries (e.g., meniscus, cartilage, fractures) in the past 12 months\n\nCurrent knee pain, swelling, or instability that prevents safe participation\n\nNeurological, cardiovascular, or systemic conditions that may affect training safety\n\nParticipation in another structured neuromuscular training program within the past 6 months","25 Years",{"count":215,"type":20},30,[23],"Basketball players often injure the anterior cruciate ligament (ACL), a key structure that stabilizes the knee. Even after surgery and standard rehabilitation, many athletes continue to have problems with knee stability, movement control, and performance during jumping and landing. These issues increase the risk of re-injury and can limit their ability to return to competition.\n\nNeuromuscular training (NMT) is a type of exercise program that focuses on improving balance, muscle coordination, and movement patterns. It uses activities such as jump-landing drills, balance tasks, agility exercises, and core training. Previous research shows that NMT can help athletes land more safely, reduce harmful knee movements, and improve sport performance. However, little is known about its long-term benefits in college basketball players who are more than one year post-ACL surgery.\n\nThis study aims to evaluate whether a 12-week NMT program, added to standard basketball training, can improve knee biomechanics, stability, and performance in college basketball players with a history of ACL reconstruction. Thirty participants will be randomly assigned to either an NMT group or a control group. Both groups will complete basketball training, but only the NMT group will receive the additional neuromuscular exercises.\n\nKnee movement will be measured using 3D motion capture and force plates, and performance will be tested through vertical jumps and other sport-specific tasks. The main outcomes will include knee angles during landing, ground reaction forces, dynamic stability, and jump height.\n\nThe expected outcome is that athletes who undergo NMT will demonstrate safer landing strategies, better knee control, and improved performance compared to those who only receive standard basketball training. These findings may help coaches and healthcare providers design safer, more effective rehabilitation programs for athletes after ACL surgery.",[219,30,220,221,222,223,224],"Anterior Cruciate Ligament Reconstruction Rehabilitation","Biomechanical Data","Athletic Performance","Physical Fitness","Neuromuscular Training","Basketball Players","2026-01-06",{"date":227,"type":40},"2026-01-07",{"date":229,"type":20},"2025-12-10",{"date":231,"type":20},"2026-05-15",{"name":233,"class":47},"Universiti Sains Malaysia",{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":15,"minAge":240,"maxAge":56,"enrollmentInfo":241,"targetDuration":4,"studyType":21,"phases":243,"briefSummary":244,"conditions":245,"keywords":247,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":255,"locationsCount":48},"100497237","the-impact-of-blood-flow-restriction-training-in-adolescents-after-acl-reconstruction-a-randomized-controlled-trial-100497237","NCT05754632","The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Prior to surgery participated in \\>50 hours\u002Fyear of level I or II sports as defined by Noyes et al and planned to return to prior level.\n\nLevel I Sports (4-7 days\u002Fweek) Jumping, hard pivoting, cutting (basketball, volleyball,football, soccer, gymnastics, skiing. wrestling)\n\n* Level II sports (1-3 days\u002Fweek) Jumping, hard pivoting, cutting (basketball, volleyball,football, soccer, gymnastics, skiing. wrestling)\n* Completion of postoperative rehabilitation following standard protocols\n* Orthopedic surgical intervention and physical therapy completed at Connecticut Children's.\n\nExclusion Criteria:\n\n* An additional lower extremity injury at time of knee injury or previous surgical intervention on the knee (ipsilateral and contralateral)\n* Multiple ligament ruptures or trauma\n* Weight bearing restrictions for greater than 4 weeks after surgery due to concomitant pathology such as meniscal root\u002Fradial repair, chondral pathology, or multi-ligament pathology\n* Follow-up surgical procedures including, but not limited to, post-operative arthrofibrosis Inability to attend regular physical therapy sessions (≥80% of patient treatment sessions and all assessment visits\n* Contraindications to performing BFRT including known history of central or peripheral neurologic impairments, cardiac or metabolic condition or history of deep vein thrombosis (DVT).","12 Years",{"count":242,"type":20},40,[23],"While there are a number studies that have reported on the use of blood flow restriction training (BFRT) in the adult population, there is limited information about the use of BFRT in the adolescent population. This study aims to evaluate the use of BFRT in conjunction with traditional anterior ligament reconstruction (ACLR) rehabilitation in adolescents.\n\nThe purpose of this study is to compare the addition of a BFRT based exercise protocol to a standard ACL rehabilitation protocol in adolescents. Does the addition of BFRT-based exercise improve strength, hypertrophy, and patient reported outcomes after ACLR in the adolescent population?",[26,30,246],"Quadriceps Muscle Atrophy",[248,249],"physical therapy","rehabilitation","2026-01-05",{"date":227,"type":40},{"date":253,"type":40},"2023-06-08",{"date":109,"type":20},{"name":256,"class":47},"Connecticut Children's Medical Center",{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":261,"acronym":262,"eligibilityCriteria":263,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":163,"enrollmentInfo":264,"targetDuration":266,"studyType":121,"phases":4,"briefSummary":267,"conditions":268,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":48},"100555065","clinical-and-instrumental-assessment-of-meniscal-root-tears-treated-through-suture-to-the-posterior-cruciate-ligament-100555065","NCT06507241","Clinical and Instrumental Assessment of Meniscal ROOT Tears Treated Through Suture to the Posterior Cruciate Ligament","ROOT-PCL","Inclusion Criteria:\n\n1. Age between 18 and 50 years at the time of surgery;\n2. Male and female gender;\n3. Patients undergoing surgical treatment for at least one year for \"ROOT\" type meniscal lesions using arthroscopic suturing to the posterior cruciate ligament;\n4. Pre-operative MRI performed.\n\nExclusion Criteria:\n\n1. Patients no longer reachable;\n2. Patients who refuse consent to the study;\n3. Previous meniscectomy before surgery;\n4. Previous ligament injuries before surgery;\n5. New traumatic injuries after surgery;\n6. Advanced knee osteoarthritis (Outerbridge grade III-IV) at the time of surgery;\n7. Severe knee malalignment (\\> 5°) at the time of surgery;\n8. Severe obesity (BMI \\> 35);\n9. Lower limb conditions preventing full weight-bearing during evaluation;\n10. Infection or hematological\u002Frheumatic conditions at the time of evaluation.",{"count":265,"type":20},59,"2 Years","The menisci are crucial for knee stability and functionality. Composed of fibrocartilaginous structure, they have an anatomical and biomechanical arrangement that makes them essential for load transmission and the prevention of osteoarthritis. Meniscal root lesions, known as \"ROOT tears,\" compromise their protective function on the cartilage, leading to increased contact pressures between the tibia and femur and, over time, the development of osteoarthritis. Early diagnosis of these lesions is difficult and often the first detection is incidental. The subsequent challenges are significant due to a lack of pre-operative planning. A possible solution is a surgical technique involving arthroscopic suture of the posterior meniscal root along with the posterior cruciate ligament. This procedure does not require pre-operative planning and is applicable even in cases of incidental diagnosis.",[269,270,30],"Meniscus Tear","Meniscus Lesion","2025-11-18",{"date":273,"type":40},"2025-11-19",{"date":275,"type":40},"2024-10-18",{"date":277,"type":20},"2027-12",{"name":182,"class":47},{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":285,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":83,"minAge":56,"maxAge":17,"enrollmentInfo":287,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":289,"conditions":290,"keywords":293,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":48},"100608441","correlation-between-psychological-readiness-knee-function-and-isokinetic-performance-after-anterior-cruciate-ligament-reconstruction-aclr-using-peroneus-longus-tendon-graft-pl-acl-2025-100608441","NCT07201597","Correlation Between Psychological Readiness, Knee Function, and Isokinetic Performance After Anterior Cruciate Ligament Reconstruction (ACLR) Using Peroneus Longus Tendon Graft (PL-ACL-2025)","Correlation Between Psychological Readiness, Knee Function and Isokinetic Performance After Anterior Cruciate Ligament Reconstruction","PL-ACLR","Inclusion Criteria:\n\n* Male recreational athletes aged 18-35 years.\n* Participation in sports that involve deceleration, jumping, cutting, or turning (e.g., basketball, soccer, volleyball).\n* Primary unilateral ACL injury treated with ACL reconstruction using a Peroneus Longus autograft.\n* Single evaluation 6-12 months after ACL reconstruction.\n* Completed a standardized postoperative rehabilitation program for ≥6 months, with near-complete rehabilitation and some level of sport participation.\n* Sufficient knee confidence, no effusion\u002Fedema, full knee range of motion, and able to perform all functional tests safely.\n* Able to provide written informed consent.\n\nExclusion Criteria:\n\n* Revision ACL reconstruction.\n* Prior ACL reconstruction on the ipsilateral or contralateral knee.\n* Multi-ligament knee injury.\n* Concomitant meniscal repair or bilateral ACL reconstruction.\n* Knee pain \\> 3\u002F10 at evaluation that prevents or impairs testing.\n* Incomplete knee extension or knee flexion \\\u003C 110°.\n* Lower-limb fracture or surgery within the past 6 months.",{"count":288,"type":20},52,"This clinical trial aims to investigate the correlation between psychological readiness, knee function, and isokinetic performance after anterior cruciate ligament reconstruction (ACLR) using the Peroneus Longus tendon graft (PLT). ACL injuries are common among athletes, and the standard treatment is ACL reconstruction surgery (ACLR). However, the success of the surgery does not solely depend on physical recovery but also on the psychological readiness of athletes to return to their sport.\n\nThis study focuses on athletes who have undergone ACLR using the Peroneus Longus tendon (PLT). The primary objective is to compare psychological readiness, self-reported knee function (IKDC score), isokinetic performance (quadriceps and hamstring strength), and muscle strength ratios between athletes who meet return-to-sport (RTS) criteria and those who do not.\n\nPsychological readiness will be assessed using the ACL-Return to Sport after Injury (ACL-RSI) scale, while knee function will be evaluated using the IKDC subjective score. Isokinetic testing will assess quadriceps and hamstring strength at various angular velocities. This study aims to provide a more comprehensive understanding of the factors influencing an athlete's ability to return to sport after ACLR, combining both physical and psychological aspects.\n\nThe results will help optimize rehabilitation strategies by offering a multidimensional approach, considering both physical and psychological factors, to improve recovery protocols for ACL-injured athletes.",[291,292,30],"Anterior Cruciate Ligament (ACL) Injury","Athletic Injuries",[294,295,296,297,298,299,300,301,302,303,304,305,306],"ACL Injury","ACL Reconstruction","Peroneus Longus Tendon","Return to Sport","Psychological Readiness","Knee Function","Isokinetic Strength Testing","Hamstring-to-Quadriceps Ratio","Post-Surgery Rehabilitation","Sports Medicine","Physical Therapy Rehabilitation","Knee Stability","peroneus longus graft","2025-09-30",{"date":309,"type":40},"2025-10-01",{"date":311,"type":20},"2025-10-08",{"date":313,"type":20},"2025-11-01",{"name":315,"class":47},"Cairo University",{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":322,"eligibilityCriteria":323,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":163,"enrollmentInfo":324,"targetDuration":4,"studyType":21,"phases":326,"briefSummary":327,"conditions":328,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":339},"100557718","fibrine-clot-augmented-repair-of-longitudinal-meniscus-tears-100557718","NCT06541756","Fibrine Clot-augmented Repair of Longitudinal Meniscus Tears","Fibrine Clot-augmented Repair of Longitudinal Meniscus Tears - A Prospectively Randomized Controlled Trial","FCAR","Inclusion Criteria:\n\n* Presenting with a painful meniscus (lateral or medial) longitudinal tear\n* Being between the ages of 18 and 50\n* Not having undergone surgery on the same knee before\n* Having an MRI taken at the end of the 1st year post-surgery\n\nExclusion Criteria:\n\n* Having additional collateral ligamentous damage along with the meniscus tear (such as MCL or LCL)\n* Incomplete clinical scores at the end of the study\n* A history of previous surgery on the same knee\n* Having an active infection\n* Not having a control MRI at the end of the 1st year",{"count":325,"type":20},120,[23],"Longitudinal meniscal tears are a type of meniscal injury characterized by a displaced fragment of the meniscus that flips over into the joint, often resembling a buckle or handle. These tears typically occur in the medial meniscus and are often associated with traumatic knee injuries, particularly in athletes.\n\nThe displaced meniscal fragment can cause mechanical symptoms such as locking, clicking, or catching of the knee, as well as pain and swelling. If not properly treated, buckle-handle meniscal tears can lead to further complications, including chronic knee instability, increased risk of osteoarthritis, and persistent joint pain.Repairing a longitudinal meniscal tear offers several advantages over partial meniscectomy, particularly in preserving knee function and preventing long-term complications.\n\nMeniscal repair aims to restore the integrity of the meniscus, which plays a crucial role in load distribution, shock absorption, and joint stability.\n\nUtilizing a fibrin clot during the repair of a buckle-handle meniscal tear can enhance the healing process and improve surgical outcomes. Fibrin clots act as a biological scaffold, promoting tissue regeneration by providing a matrix that facilitates cellular migration and proliferation.\n\nThe purpose of this study was to compare longitudinal meniscal tear repair reinforced with fibrin clot with routine end-to-end repair in a prospective randomized controlled trial.",[269,270,329,30],"Fibrin Blood Clot","2025-09-29",{"date":332,"type":40},"2025-10-02",{"date":334,"type":40},"2024-07-25",{"date":336,"type":20},"2029-07-31",{"name":338,"class":47},"Ankara City Hospital Bilkent",2,{"id":341,"slug":342,"hasResults":11,"nctId":343,"briefTitle":344,"officialTitle":344,"acronym":345,"eligibilityCriteria":346,"healthyVolunteers":11,"sex":15,"minAge":240,"maxAge":347,"enrollmentInfo":348,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":350,"conditions":351,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":48},"100606335","clinical-instrumental-evaluation-and-assessment-of-return-to-sports-activity-in-patients-surgically-treated-for-isolated-stener-like-lesions-of-the-medial-collateral-ligament-mcl-or-in-the-context-of-multiligament-injuries-and-articular-fractures-100606335","NCT07174219","Clinical-instrumental Evaluation and Assessment of Return to Sports Activity in Patients Surgically Treated for Isolated \"Stener-like\" Lesions of the Medial Collateral Ligament (MCL) or in the Context of Multiligament Injuries and Articular Fractures","STENER_MCL","Inclusion Criteria:\n\n* Patients of both male and female sex.\n* Patients who underwent surgical re-insertion of the distal insertion of the medial collateral ligament starting from 01\u002F01\u002F2020 and all patients scheduled for this type of surgical intervention until 12\u002F31\u002F2027;\n* Patients aged between 12 and 65 years at the time of surgery;\n* Patients who underwent isolated distal medial collateral ligament re-insertion surgery, as well as those who underwent the same procedure combined with other interventions on the same knee (e.g., multiligament injuries, reduction and osteosynthesis of bone fractures);\n* Patients who have given consent to participate in the study;\n* Patients who have undergone preoperative radiological investigations of the affected knee confirming the diagnosis of distal medial collateral ligament injury (MRI in the case of ligament injuries; X-ray and\u002For CT scan in the case of articular fractures).\n\nExclusion Criteria:\n\n* Previous fractures of the same limb treated surgically.\n* Patient age under 12 years at the time of surgery or patients over 65 years of age.\n* Patients who have not provided informed consent.\n* Patients who are no longer contactable.\n* Patients who have not engaged in sports activity in the 2 years prior to the surgical intervention.","65 Years",{"count":349,"type":20},43,"The knee is a complex joint stabilized by four main ligaments: the anterior and posterior cruciate ligaments and the medial and lateral collateral ligaments. Multiligamentous knee injuries involve at least two ligaments and usually result from high-energy trauma, causing significant functional limitations.\n\nOne specific injury is the \"Stener-like\" lesion of the medial collateral ligament (MCL), characterized by an avulsion at its distal tibial insertion with interposition of tendons from the pes anserinus, which prevents natural healing. This lesion often occurs with other ligament or bone injuries and requires surgical treatment.\n\nDiagnosis is clinical, supported by MRI to confirm the distal lesion and tendon interposition. Despite its importance, literature on this injury is scarce, with only a few studies and case reports, often limited by small sample sizes and lack of standardized follow-up assessments.\n\nDue to the rarity and complexity of these injuries, there is a need for a comprehensive clinical study with standardized evaluations to improve understanding and develop standardized surgical treatments for isolated and associated Stener-like MCL lesions.",[352,30],"Ligament Injury","2025-09-15",{"date":355,"type":40},"2025-09-16",{"date":357,"type":40},"2025-09-10",{"date":359,"type":20},"2030-08",{"name":361,"class":47},"Stefano Zaffagnini",{"id":363,"slug":364,"hasResults":11,"nctId":365,"briefTitle":366,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":17,"enrollmentInfo":368,"targetDuration":4,"studyType":21,"phases":369,"briefSummary":370,"conditions":371,"keywords":373,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":391},"100604137","effects-of-early-rehabilitation-using-blood-flow-restriction-andor-surface-electromyography-biofeedback-on-quadriceps-activation-and-strength-after-anterior-cruciate-ligament-reconstruction-a-multicenter-randomized-controlled-trial-100604137","NCT07145606","Effects of Early Rehabilitation Using Blood Flow Restriction and\u002For Surface Electromyography Biofeedback on Quadriceps Activation and Strength After Anterior Cruciate Ligament Reconstruction: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18-35 years.\n\nFirst-time anterior cruciate ligament (ACL) reconstruction.\n\nPre-injury activity level Tegner ≥ 6.\n\nMarx activity scale ≥ 12.\n\nBody mass index \\\u003C 35.\n\nWith or without associated meniscal injury.\n\nExclusion Criteria:\n\n* Revision ACL surgery.\n\nConcurrent repair of other knee ligaments.\n\nNeurological or systemic musculoskeletal disorders.\n\nContraindications to blood flow restriction (BFR) or surface EMG monitoring\u002Fbiofeedback.\n\nPregnancy or lactation.\n\nLanguage barrier or cognitive impairment preventing valid informed consent; vulnerable populations not enrolled.",{"count":166,"type":20},[23],"Many patients experience quadriceps inhibition after anterior cruciate ligament (ACL) reconstruction, delaying strength recovery, hindering return to sport, and potentially increasing the risk of re-injury. Two rehabilitation strategies-low-load blood flow restriction (BFR) training and surface electromyography (sEMG) biofeedback-aim to enhance neuromuscular activation and strength while limiting joint load. However, comparative and combined evidence in pragmatic, multicenter settings remains limited.\n\nAMIRACL is a multicenter, prospective, randomized, controlled, parallel-group trial with four arms enrolling 200 adults (18-35 years) undergoing a first-time ACL reconstruction. Participants are randomized with center stratification; outcome assessors are blinded to allocation. The four groups are: (1) standard rehabilitation; (2) standard + early BFR; (3) standard + early sEMG biofeedback; and (4) standard + combined BFR and sEMG biofeedback. Interventions begin about 2 weeks postoperatively, are delivered over 6 weeks at three supervised sessions per week, and are integrated into contemporary ACL rehabilitation. BFR uses individualized, auto-regulated cuff pressure during low-load isometric and then dynamic exercises. sEMG biofeedback provides real-time visual and\u002For auditory feedback to optimize quadriceps recruitment during targeted tasks. The combined arm receives both modalities concurrently.\n\nThe primary objective is to compare quadriceps activation (sEMG) and maximal isometric knee extensor strength between groups at 3 and 6 months. Secondary objectives include return-to-sport readiness and patient-reported function (e.g., ACL-RSI, IKDC), broader knee outcomes (e.g., KOOS, Lysholm), adherence and adverse events across arms, and ACL re-injury (ipsilateral graft rupture or contralateral ACL injury) within 2 years. Longer-term patient-reported quality of life is explored up to 5 years.\n\nKey eligibility criteria include age 18-35 years, first ACL reconstruction, and preinjury sport participation; major exclusions include revision ACL surgery, concomitant multi-ligament repair, neuromuscular disorders, and contraindications to BFR or sEMG. The planned sample size is 200 (50 per arm), powered to detect a clinically meaningful between-group difference in quadriceps activation. Analyses will follow the intention-to-treat principle using mixed-effects models for repeated measures. The study is conducted under Good Clinical Practice and applicable Swiss regulations; all participants provide written informed consent. Overall, AMIRACL will determine whether early BFR, sEMG biofeedback, or their combination meaningfully improves quadriceps activation, strength, and clinical recovery after ACL reconstruction compared with standard rehabilitation alone.",[26,30,372],"Muscle Weakness",[374,295,30,375,376,377,378,379,380,381,34,297],"Anterior Cruciate Ligament","Rehabilitation","Quadriceps Muscle","Quadriceps Activation","Muscle Strength","Arthrogenic Muscle Inhibition","Blood Flow Restriction Training","Surface Electromyography","2025-08-21",{"date":384,"type":40},"2025-08-28",{"date":386,"type":20},"2026-01-02",{"date":388,"type":20},"2031-01-02",{"name":390,"class":47},"Haute Ecole ARC Sante",4,{"id":393,"slug":394,"hasResults":11,"nctId":395,"briefTitle":396,"officialTitle":397,"acronym":4,"eligibilityCriteria":398,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":399,"enrollmentInfo":400,"targetDuration":4,"studyType":21,"phases":402,"briefSummary":403,"conditions":404,"keywords":405,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":410,"completionDateStruct":412,"leadSponsor":414,"locationsCount":339},"100279542","fixation-of-patellar-tendon-grafts-in-anterior-cruciate-ligament-reconstruction-endobutton-vs-metal-interference-screws-100279542","NCT02918734","Fixation of Patellar Tendon Grafts in Anterior Cruciate Ligament Reconstruction. Endobutton vs Metal Interference Screws","A Prospective Randomized Controlled Trial Comparing the Endobutton CL BTB Fixation System With Metal Interference Screws in the Femoral Fixation of Patellar Tendon Grafts in Anterior Cruciate Ligament Reconstruction.","Inclusion Criteria:\n\n* Primary reconstruction of ACL ruptures\n* Surgery at least 6 weeks after injury\n* The patient must accept and sign the informed consent form before surgery\n\nExclusion Criteria:\n\n* Medical indication for using another graft than BPTB autograft (such as history of anterior knee pain or occupations etc. requiring frequent kneeling)\n* Previous major surgical procedures in the same knee\n* Major additional injuries in the knee (posterior cruciate ligament, lateral collateral ligament, medial collateral ligament, sutured meniscus lesions and major cartilage lesions undergoing cartilage repair)\n* Contralateral ACL injury (treated or untreated)\n* Present or former serious illness that makes follow-up or rehabilitation difficult (e.g. alcohol or drug abuse, psychiatric disease)","55 Years",{"count":401,"type":20},220,[23],"In this randomized controlled trial the investigators will compare the results after primary anterior cruciate ligament (ACL) reconstruction using two different methods for femoral fixation of a bone-patellar tendon-bone (BPTB) autograft. Interference screws have been the standard method for fixing the femoral side of BPTB grafts; however, several pitfalls have been reported. Cortical fixation with the Endobutton CL BTB Fixation System has become available and the clinical results have been described as promising; however, no randomized controlled trials comparing these two femoral fixation methods have been conducted, and there is no published data that confirms that the bone block heals in the tunnel with the newer method.\n\nThe aim of our study is to compare the outcome after primary ACL reconstruction with BPTB autografts using the Endobutton CL BTB or metal interference screw for femoral fixation.",[30],[374,406],"Bone-Patellar Tendon-Bone Grafting","2025-07-09",{"date":409,"type":40},"2025-07-10",{"date":411,"type":40},"2016-10",{"date":413,"type":20},"2033-03",{"name":415,"class":47},"St. Olavs Hospital",{"id":417,"slug":418,"hasResults":11,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":422,"eligibilityCriteria":423,"healthyVolunteers":11,"sex":15,"minAge":424,"maxAge":425,"enrollmentInfo":426,"targetDuration":4,"studyType":21,"phases":428,"briefSummary":429,"conditions":430,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":391},"100405041","blood-flow-restriction-training-after-patellar-instability-100405041","NCT04554212","Blood Flow Restriction Training After Patellar INStability","Blood Flow Restriction Training After Patellar INStability (BRAINS Trial)","BRAINS","Inclusion Criteria:\n\n* Diagnosis of traumatic patellar instability (either primary or recurrent) determined by an American Board of Family Medicine certified physician with a Certificate of Added Qualifications in Sports Medicine or licensed Physical Therapist utilizing clinical examination, radiographic imaging, and patients' reports of instability\n* Age 14 to 40 years\n* Skeletally mature with closed growth plates visualized by radiograph\n* A score of 80 or more on the Sports Activity Scale, which corresponds to participating in \"running, twisting, turning (tennis, racquetball, handball, ice hockey, field hockey, skiing, wrestling)\" at least 1-3 times per week\n* Desire to resume pre-injury activity level\n\nExclusion Criteria:\n\n* Concomitant osteochondral lesion requiring surgical fixation\n* Radiographic evidence of osteoarthritis (\\\u003C Kellgren-Lawrence Grade 2)\n* Previous ipsilateral or contralateral knee surgery\n* Most recent instability event more than 3 months before enrollment\n* History of any inflammatory disorder\n* BMI \\> 35 kg\u002Fm2\n* Diabetes or uncontrolled hypertension\n* Varicose veins or a history of personal or immediate family history (parental or sibling) of deep vein thrombosis\n* Pre-existing conditions or previous surgeries that effect the ability to walk\n* Planned trips or vacations that will result in the inability to attend 4 consecutive physical therapy sessions","14 Years","40 Years",{"count":427,"type":20},78,[23],"This research study is designed to allow health care professionals and researchers to answer many questions about whether a new type of physical therapy called blood flow restriction training (called BFRT) will improve recovery for those with patellar instability.",[431,30,432,433],"Patellar Dislocation","Leg Injury","Wounds and Injuries","2025-07-02",{"date":436,"type":40},"2025-07-03",{"date":438,"type":40},"2020-09-09",{"date":440,"type":20},"2026-06-30",{"name":442,"class":47},"Caitlin Conley",{"id":444,"slug":445,"hasResults":11,"nctId":446,"briefTitle":447,"officialTitle":448,"acronym":4,"eligibilityCriteria":449,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":4,"enrollmentInfo":450,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":452,"conditions":453,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":455,"lastUpdatePostDateStruct":456,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":462,"locationsCount":465},"100540752","sportspro-post-market-clinical-follow-up-study-100540752","NCT06320925","SportsPro: Post-Market Clinical Follow Up Study","A Retrospective, Multi-Center, Post-Market Clinical Follow-Up Study of Stryker Class IIb Implants","Inclusion Criteria:\n\n1. Subject was ≥ 18 years of age at the time of the surgery\n2. Subject has undergone joint space repair using one of the study devices\n\nExclusion Criteria:\n\n1. Subjects who are less than 6 months post-intervention\n2. Concurrent participation in an investigational clinical study during the study period",{"count":451,"type":20},1500,"Retrospective, multi-center, chart review (only to include data that is part of the surgeons' standard practice)",[195,30,454],"Hip Injuries","2025-05-22",{"date":457,"type":40},"2025-05-29",{"date":459,"type":40},"2023-12-05",{"date":461,"type":20},"2026-12-01",{"name":463,"class":464},"Stryker Endoscopy","INDUSTRY",3,{"id":467,"slug":468,"hasResults":11,"nctId":469,"briefTitle":470,"officialTitle":471,"acronym":4,"eligibilityCriteria":472,"healthyVolunteers":82,"sex":15,"minAge":424,"maxAge":473,"enrollmentInfo":474,"targetDuration":4,"studyType":21,"phases":476,"briefSummary":477,"conditions":478,"keywords":479,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":482,"lastUpdatePostDateStruct":483,"startDateStruct":485,"completionDateStruct":487,"leadSponsor":489,"locationsCount":48},"100444887","non--vs-partial-controlled-weightbearing-after-multiple-knee-ligament-reconstruction-100444887","NCT05073276","Non- Vs Partial Controlled Weightbearing After Multiple Knee Ligament Reconstruction","Non-Weight Bearing Versus Partial Controlled Weightbearing During the First Six Weeks of Rehabilitation After Multiple Knee Ligament Reconstruction: a Randomized Controlled Trial","Inclusion Criteria:\n\n* ≥ 14 years old, \\\u003C60\n* Reconstruction of PCL alone\n* Reconstruction of MCL alone\n* Reconstruction of combined multiligament injuries (PCL+ (FCL, PLC, ACL, MCL))\n* Reconstruction of multiligament injuries (ACL+MCL)\n* Males or females\n* Is willing and able to comply with the clinical trial plan and able to understand and sign the Patient Informed Consent Form.\n\nExclusion Criteria:\n\n* \\\u003C 14 years old\n* \\>60 years old\n* Pregnant\n* Revision PCL reconstructions\n* Previous or concurrent vascular injury (vascular bypass procedure)\n* Associated fractures requiring concurrent surgery\n* Concurrent meniscal root or radial repair surgery","59 Years",{"count":475,"type":20},50,[23],"This is a prospective randomized controlled trial with the purpose to determine if patients undergoing isolated posterior cruciate ligament (PCL) reconstruction, or isolated medial collateral ligament (MCL) reconstruction, or combined PCL, anterior cruciate ligament (ACL), fibular collateral ligament (FCL), posterolateral corner (PLC), and MCL reconstructions (or any combination of multiple ligaments) can safely begin partial controlled weightbearing for the first six weeks after surgery.",[30],[480,481],"anterior cruciate ligament (ACL)","Multiple Knee Ligament Reconstruction","2024-11-20",{"date":484,"type":40},"2024-11-22",{"date":486,"type":40},"2020-01-01",{"date":488,"type":20},"2026-01",{"name":490,"class":47},"Twin Cities Orthopedics",{"id":492,"slug":493,"hasResults":11,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":4,"eligibilityCriteria":497,"healthyVolunteers":82,"sex":15,"minAge":424,"maxAge":473,"enrollmentInfo":498,"targetDuration":4,"studyType":21,"phases":499,"briefSummary":500,"conditions":501,"keywords":502,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":482,"lastUpdatePostDateStruct":504,"startDateStruct":505,"completionDateStruct":506,"leadSponsor":507,"locationsCount":48},"100444886","full-vs-partial-weightbearing-during-the-first-six-weeks-of-rehab-after-fibular-collateral-ligament-reconstruction-100444886","NCT05073263","Full Vs Partial Weightbearing During the First Six Weeks of Rehab. After Fibular Collateral Ligament Reconstruction","Full Weightbearing Versus Partial Controlled Weightbearing During the First Six Weeks of Rehabilitation After Reconstruction of the Fibular Collateral Ligament: a Randomized Controlled Trial","Inclusion Criteria:\n\n* ≥ 14 years old, \\\u003C60\n* Reconstruction of FCL alone\n* Combined FCL + ACL reconstructions\n* Males or females\n* Is willing and able to comply with the clinical trial plan and able to understand and sign the Patient Informed Consent Form.\n\nExclusion Criteria:\n\n* \\\u003C 14 years old, \\> 60\n* Pregnant\n* Revision FCL reconstructions\n* Concurrent biceps femoris or lateral capsular repairs\n* Concurrent PCL or MCL reconstructions\n* Concomitant meniscus root or radial repair surgery with transtibial technique",{"count":475,"type":20},[23],"This is a prospective randomized controlled trial with the purpose to determine if patients undergoing fibular collateral ligament (FCL) reconstruction alone or combined FCL and anterior cruciate ligament (ACL) reconstructions can safely begin full controlled weightbearing for the first six weeks after surgery.",[30],[503,480],"fibular collateral ligament (FCL)",{"date":484,"type":40},{"date":486,"type":40},{"date":488,"type":20},{"name":490,"class":47},{"id":509,"slug":510,"hasResults":11,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":4,"eligibilityCriteria":514,"healthyVolunteers":82,"sex":15,"minAge":56,"maxAge":84,"enrollmentInfo":515,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":517,"conditions":518,"keywords":519,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":523,"startDateStruct":525,"completionDateStruct":527,"leadSponsor":529,"locationsCount":4},"100562130","evaluation-of-vastus-medialis-muscle-inhibition-in-indoor-soccer-players-with-and-without-acl-injury-100562130","NCT06599164","Evaluation of Vastus Medialis Muscle Inhibition in Indoor Soccer Players With and Without ACL Injury","Evaluation of Muscular Anthrogenic Inhibition of the Vasto Medialis in Indoor Soccer Players With Anterior Cruciate Ligament (ACL) Injury in Comparison With Non-Injured Players: Observational Cohort Study","Inclusion Criteria:\n\n* Age between 18 and 45 years old\n* Playing in the Spanish National League (first or second category) or in the Madrid Futsal Federation in PRIMERA RFFM and PREFERENTE.\n* Both sexes\n* Have been playing futsal for at least 2 years\n* Enrolled in the Madrid Health System\n* Any language\n\nExclusion Criteria:\n\n* Operations other than an Anterior Cruciate Ligament injury (Cartilage, Meniscus, Ligaments).\n* Injuries to the knee of the contralateral lower limb. (sprains, fracture)\n* Muscle injuries or conditions in the affected or contralateral limb for less than 2 months (sprains, tibial periostitis, tendinopathies, tears).\n* Any infection must be reported after the intervention and will be excluded from the study.\n* Players will not be allowed to play any kind of team sport other than Futsal in an official way during this season.\n* Players may not have any cardiovascular or respiratory pathology that would affect the study.\n* Players who have already undergone an Anterior Cruciate Ligament rupture in previous years will not be considered.",{"count":516,"type":20},64,"The Anterior Cruciate Ligament (ACL) is vital for knee stability, and ACL injuries in futsal can lead to long-term issues. Reconstruction surgery may be affected by Anthrogenic Muscle Inhibition (AMI), especially in the vastus medialis muscle. This study aims to compare AMI in futsal players with ACL injuries to those without injuries, focusing on measurement techniques, sports performance, muscle strength, and recovery time. The research involves evaluating 54 players (27 injured and 27 non-injured) at various stages of the season using strength tests and imaging.",[26,30],[520,521,374,375],"Anthrogenic Muscle Inhibition","Soccer","2024-09-12",{"date":524,"type":40},"2024-09-19",{"date":526,"type":20},"2025-09-01",{"date":528,"type":20},"2026-08-31",{"name":530,"class":47},"University of Alcala",{"id":532,"slug":533,"hasResults":11,"nctId":534,"briefTitle":535,"officialTitle":536,"acronym":537,"eligibilityCriteria":538,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":4,"enrollmentInfo":539,"targetDuration":541,"studyType":121,"phases":4,"briefSummary":542,"conditions":543,"keywords":550,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":555,"lastUpdatePostDateStruct":556,"startDateStruct":558,"completionDateStruct":560,"leadSponsor":562,"locationsCount":48},"100550779","knee-osteoarthritis-in-the-region-of-norrbotten-100550779","NCT06451510","Knee Osteoarthritis in the Region of Norrbotten","Knee Osteoarthritis in the Region of Norrbotten (KORN)","KORN","Inclusion Criteria:\n\n* Patients from the region of Norrbotten (northern part of Sweden) who underwent tibial plateau fracture between the years of 2001 and 2015\n\nExclusion Criteria:\n\n* Death without bilateral weighted X-ray minimum 5 years post injury\n* Open growth plate in distal femur and\u002For proximal tibia\n* Extraarticular or isolated eminentia fracture\n* OA prior to injury\n* Having a rheumatic disorder involving joints\n* Earlier and\u002For later severe injury to the index knee\n* Having cognitive disorders disqualifying from the study",{"count":540,"type":20},500,"10 Years","The goal of this observational study is to assess the prevalence of radiographic knee osteoarthritis and to report medium and long term functional outcomes secondary to tibia plateau fractures. The second aim was to investigate whether there were any risk factors associated with these outcomes.",[544,30,28,545,546,547,548,549],"Osteoarthritis","Tibial Plateau Fractures","Tibial Fractures","Patient Satisfaction","Quality of Life","Complication of Treatment",[544,551,552,553,554],"Knee","Tibial plateau fracture","Outcome","Arthroplasty","2024-06-17",{"date":557,"type":40},"2024-06-18",{"date":559,"type":40},"2020-09-01",{"date":561,"type":20},"2027-12-31",{"name":563,"class":47},"Umeå University",{"id":565,"slug":566,"hasResults":11,"nctId":567,"briefTitle":568,"officialTitle":569,"acronym":4,"eligibilityCriteria":570,"healthyVolunteers":11,"sex":15,"minAge":56,"maxAge":84,"enrollmentInfo":571,"targetDuration":4,"studyType":21,"phases":572,"briefSummary":573,"conditions":574,"keywords":575,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":577,"lastUpdatePostDateStruct":578,"startDateStruct":580,"completionDateStruct":582,"leadSponsor":584,"locationsCount":48},"100550073","the-efficiency-and-safety-of-prp-treatment-after-anterior-cruciate-ligament-reconstruction-100550073","NCT06442319","The Efficiency and Safety of PRP Treatment After Anterior Cruciate Ligament Reconstruction.","The Efficiency and Safety of Platelet-rich Plasma Intra-articular Injections After Anterior Cruciate Ligament Reconstruction: MRI and Clinical Outcome Analysis.","Inclusion Criteria:\n\n* subject is 18-45 years old\n* subject has BMI \\\u003C 40 kg\u002Fm2\n* subject had ACL reconstrution\n* small asymptomatic meniscal lesions that won't require repair\n* subject must be willing to abstain from other intra-articular treatments of the knee for the duration of the study.\n* subject is willing to discontinue all analgesics including nonsteroidal anti-inflammatory drugs (NSAIDs), except tramadol and paracetamol, at least one month before the synovial fluid aspiration and through the completion of the study\n* subject is able to understand and comply with the requirements of the study and voluntarily provides consent\n\nExclusion Criteria:\n\n* subject has a history of metabolic diseases, endocrine disorders, rheumatic and connective tissue diseases, cancer, hormonal contraception, steroid therapy, antibiotic therapy\n* subject had an intraarticular injection into the affected joint\n* subject had previous operations (beside ACL reconstruction) or fractures of the affected limb\n* subject has a history of nicotine, alcohol, or drug addiction\n* subject has a meniscal tear that requires suturing or total meniscectomy seen on MRI\n* subject has multi-ligament knee injuries or multi-organ injury\n* subject has significant varus or valgus deformity greater than 10 degrees in either knee, determined by an X-ray",{"count":86,"type":20},[23],"The anterior cruciate ligament (ACL) is the main stabilizer of the knee joint, as it controls anteroposterior and rotatory knee laxity. The number of ACL injuries has increased in the past three decades because more and more people participate in recreational and competitive sporting activities. Injury to the ACL often leads to functional instability, damage to the meniscus and articular cartilage, and an increased risk for osteoarthritis (OA). Emphasizes the fact that ACL has limited healing potential 'The gold standard' treatment is ACL reconstruction, with over 200,000 reconstruction surgeries performed annually in the United States. However, despite the success of surgery in restoring functional stability, it has been found so far in several studies that the prevalence of moderate to severe arthritis in long-term radiographic follow-up is more than 50% after ACL reconstruction within 5 to 15 years or sooner. ACL-injured knees had at least 3 times higher risk of arthritis than uninjured contralateral knees. Early osteoarthritis was observed on magnetic resonance imaging (MRI) up to 11 years following ACL injury after operative and nonoperative management. Because ACL injuries predominantly occur in individuals between the ages of 15 and 25 years, symptoms of OA most often affect patients during their most productive years. This is worrisome because most patients who sustain ACL tears are free of the risk of other factors for developing OA.Consequently, posttraumatic OA after ACL reconstruction ultimately translates into a large economic effect on the healthcare system owing to the young age of this population. Platelet-rich plasma is an autologous solution of highly concentrated platelets dispersed in a small capacity of plasma. Enthusiasm for the therapeutic potential of platelets is based on its rich omplement of anabolic growth factors and anti-inflammatory cytokines in the platelets, which induce cellular proliferation, migration, differentiation, angiogenesis, and extracellular matrix synthesis. In addition, the functional mechanisms of PRP in OA treatment have been explained by its effect on modulating critical pro-inflammatory mediators and catabolic enzymes, as well as maintaining joint homeostasis. The reasons for this early incidence of post-traumatic OA remain unclear, but the underlying mechanisms have been speculated to involve some combination of cartilage damage at the time of injury, and posttraumatic molecular changes in the joint, including immune reactions or persistent secondary inflammation. We hypothesized that PRP injection after ACL reconstruction could prevent cartilage damage, act anti-inflammatory, and provide better clinical and radiological outcomes seen in MRI.",[294,28,30],[576],"PRP, ACL reconstruction, knee osteoarthritis","2024-05-29",{"date":579,"type":40},"2024-06-04",{"date":581,"type":20},"2024-06-01",{"date":583,"type":20},"2030-04-15",{"name":585,"class":47},"Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz",{"id":587,"slug":588,"hasResults":11,"nctId":589,"briefTitle":590,"officialTitle":591,"acronym":592,"eligibilityCriteria":593,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":594,"targetDuration":4,"studyType":21,"phases":596,"briefSummary":597,"conditions":598,"keywords":601,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":606,"lastUpdatePostDateStruct":607,"startDateStruct":609,"completionDateStruct":611,"leadSponsor":613,"locationsCount":339},"100531102","stopping-osteoarthritis-after-an-acl-tear-100531102","NCT06195423","Stopping OsteoARthritis After an ACL Tear","The Stop Osteoarthritis (SOAR) Hybrid Effectiveness-Implementation Type 1 Randomized Controlled Trial for Young People At-High-Risk of Early Onset Knee Osteoarthritis","SOAR","Inclusion Criteria:\n\n* Currently live in British Columbia, Canada\n* 16-35 years of age (inclusive)\n* 9-36-months past a first-time ACLR performed ≤12-months of first-time ACL tear\n* Currently not receiving knee care from a health or fitness provider and have no scheduled surgical procedures (any part of the body) that would interfere with exercise during the study.\n* Score below a KOOS4 PASS (\\\u003C79 points)\n* Have daily access to an email address and a computer with internet\n* Are willing to wear an activity tracker during the study\n\nExclusion Criteria:\n\n* Inability to communicate in English\n* No medical attention (healthcare provider) time-loss (missed physical activity, sport or work ≥2 occasions) injury to the ACLR knee before the ACL tear\n* Previous physician diagnosis of index knee osteoarthritis\n* Inflammatory arthritis or other systemic condition\n* Lower limb injury, surgery, or intra-articular injection in the past 6-months\n* Current pregnancy\n* MRI contraindications (i.e., Weight over 400 lbs (MRI machine limit); Pacemaker or any other implanted medical device (i.e., wires, defibrillator, artificial heart valve, an electronic device like a drug infusion pump, electrical stimulator for nerves or bones, coil, catheter, or filter in any blood vessel, ear or eye implant, or stainless steel intrauterine device (IUD); Brain or ferromagnetic aneurysm clip; any other metallic prostheses or shrapnel, bullets, or other metal fragments; injury where a piece of metal lodged in the eye or orbit, or; surgery, medical procedure or tattoos (including tattooed eyeliner) in the last 6 weeks).",{"count":595,"type":20},210,[23],"By 2040, 25% of Canadians will have osteoarthritis, a disabling joint condition. Most people think osteoarthritis only affects older adults, but 50% of the 700,000 Canadian youth who hurt their knee playing sports annually will develop osteoarthritis by 40 years of age. These young people with old knees face knee pain and disability for much of their adult lives, interfering with parenting, work, and recreation. Yet, most do not know about osteoarthritis or how to reduce their risk.\n\nIn this clinical trial, people who have torn the Anterior Cruciate ligament in their knee and had reconstruction surgery 9-36 months previously will be randomized to receive either a 6-month virtual education and exercise therapy program called Stop OsteoARthritis (SOAR) or a minimal intervention control program. Researchers will test if those who received the SOAR program have larger gains in knee health, including pain, symptoms, function, and quality of life at 6, 12, and 24 months. Researchers will also use MRIs (baseline and 24 months) to assess how the SOAR program influences knee cartilage degeneration and its cost-effectiveness.",[30,599,600],"Anterior Cruciate Ligament Rupture","Osteoarthritis, Knee",[602,603,551,604,605,375],"Randomized controlled trial","Post-traumatic osteoarthritis","Osteoarthritis prevention","Exercise","2024-05-08",{"date":608,"type":40},"2024-05-10",{"date":610,"type":40},"2024-05-01",{"date":612,"type":20},"2028-12-30",{"name":614,"class":47},"University of British Columbia"]