[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"knee-injury-simulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:knee-injury-simulation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100592870","early-phase-1-quadriceps-motor-unit-adaptation-to-simulated-knee-injury-100592870",false,"NCT06999057","Quadriceps Motor Unit Adaptation to Simulated Knee Injury","Inclusion Criteria:\n\n1. Age 18-30 years\n2. Physically active (Tegner ≥ 5)\n3. No prior lower-limb surgery or major injury\n\nExclusion Criteria:\n\n1. Lower limb surgery or significant injury in past 2 years\n2. Cardiopulmonary, neurological, or psychiatric disorders\n3. Needle\u002Felectrical stimulation anxiety\n4. Medications affecting neuromuscular or psychological function\n5. Pregnancy\n6. Allergic to lidocaine\n7. Inability to elicit Hoffmann reflex",true,"ALL","18 Years","30 Years",{"count":20,"type":21},45,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscular testing during a single 2-hour lab session. This research seeks to improve understanding of muscle inhibition and inform interventions after real-world knee trauma.",[27,28],"Muscle Inhibition","Knee Injury Simulation",[30,31,32,33,34,35,36,37],"Quadriceps","Electromyography","Motor Unit","Knee Effusion","Lidocaine","Deafferentation","Neuromuscular Adaptation","Muscle Strength","RECRUITING","2026-04-27",{"date":41,"type":42},"2026-05-01","ACTUAL",{"date":44,"type":21},"2026-08-01",{"date":46,"type":21},"2027-08-01",{"name":48,"class":49},"University of Central Florida","OTHER"]