[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"knee-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:knee-injury":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100641432","reducing-disparities-in-knee-arthroscopy-for-adolescents-100641432",false,"NCT07580625","Reducing Disparities in Knee Arthroscopy for Adolescents","RED KARD: Reducing Disparities in Knee Arthroscopy for Adolescents","RED KARD","Inclusion Criteria:\n\n* Predominantly Hispanic soccer team\n* Players between 14-18 years of age\n\nExclusion Criteria:\n\n-Players younger than 14 or older than 18 years of age","ALL","14 Years","18 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","Hundreds of thousands of youth athletes require surgery for knee injuries annually. The incidence of operative knee injuries has skyrocketed, but surgery can be delayed due to late recognition and barriers, such as insurance, language, and difficulty navigating the healthcare system. Delays may have lifelong effects, including arthritis, persistent instability, poor patient reported outcomes, and reoperation. There is little patient-centered research on barriers to orthopaedic care, and none on interventions to reduce disparities in pediatric sports medicine. This study will focus on Hispanic children, a growing population nationally and 38% of the Chicago's children, who are at increased risk of delayed knee surgery and its sequelae compared to white, non-Hispanic patients. The overall objectives are to identify barriers to timely knee surgery in Hispanic athletes and develop an intervention to implement evidence on expedient treatment. The aim of this study is to evaluate feasibility, acceptability, and appropriateness of a culturally-tailored intervention in a pilot study of Hispanic youth soccer leagues. The proposed study will drive creation of a future community trial of a culturally-tailored intervention.",[28,29,30,31,32],"Knee Injury","ACL Injury","Meniscus Tear","Hispanic or Latino","Adolescent","NOT_YET_RECRUITING","2026-06-16",{"date":36,"type":37},"2026-06-18","ACTUAL",{"date":39,"type":22},"2027-10-01",{"date":41,"type":22},"2029-07",{"name":43,"class":44},"Ann & Robert H Lurie Children's Hospital of Chicago","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100605082","early-phase-1-investigating-the-safety-and-regenerative-potential-of-msc-derived-secretome-combined-with-prgf-in-knee-osteoarthritis-100605082","NCT07157891","Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee Osteoarthritis","PRGFSECKOA","Inclusion Criteria:\n\n* Following is the inclusion criteria for the enrolment of patients affected with damaged cartilage in this study:\n\n  * Diagnosed with primary OA in one or both knees based on American College of Rheumatology criteria\n  * Grade I and II Arthritis\n  * Joint pain ≥ 20mm measured by visual analogue scale\n  * Age ranges from 30-55 years of age\n  * BMI 27.12 ± 4.38\n  * Patients with no previous surgical interventions to lower limb\n  * Willing to participate in the study\n\nExclusion Criteria:\n\n* • Secondary OA due to trauma, infection, rheumatoid arthritis, congenital disease or other inflammatory disorders of the knee\n\n  * Diagnosed with a systemic autoimmune disorder, immunodeficiency or coagulation disorder\n  * Had history of malignancy\n  * History of allergy or allergic constitution\n  * Pregnant or breastfeeding women.","30 Years","55 Years",{"count":56,"type":22},25,[58],"EARLY_PHASE1","This Phase I\u002FII randomized clinical trial investigates the safety, feasibility, and early regenerative potential of intra-articular administration of mesenchymal stem cell (MSC)-derived secretome combined with Plasma Rich in Growth Factors (PRGF) in patients with knee osteoarthritis (KOA). The study aims to assess whether this cell-free, biologically enriched therapeutic combination can reduce pain, improve joint function, and promote cartilage repair.",[61,28,62],"Osteoarthritis (OA)","Cartilage Degeneration",[64,65,66,67,68,69,70],"Mesenchymal Stem Cell Secretome","Plasma Rich in Growth Factors (PRGF)","Platelet-Rich Plasma (PRP)","Knee Osteoarthritis","Intra-articular Injection","Cell-free Therapy","Regenerative Medicine","2025-08-28",{"date":73,"type":37},"2025-09-05",{"date":75,"type":22},"2025-12-10",{"date":77,"type":22},"2028-12-11",{"name":79,"class":44},"University of the Punjab",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":45},"100591427","comparison-of-quadriceps-and-semitendinosus-grafts-in-acl-reconstruction-using-data-from-the-danish-knee-ligament-reconstruction-registry-dkrr-100591427","NCT06980285","Comparison of Quadriceps and Semitendinosus Grafts in ACL Reconstruction Using Data From the Danish Knee Ligament Reconstruction Registry (DKRR)","ACL Reconstruction With Quadriceps Tendon Graft vs. Quadrupled Semitendinosus Graft: A Comparison of Patients From the Danish National ACL Reconstruction Database","Inclusion Criteria:\n\n* Primary ACL reconstruction registered in the Danish Knee Ligament Reconstruction Registry (DKRR)\n* Known graft type: quadriceps tendon or semitendinosus tendon Minimum 1-year follow-up with completed patient-reported outcome measures (KOOS and\u002For Tegner score)\n* Age between 15 and 50 years at the time of surgery (optional subgroup analysis)\n\nExclusion Criteria:\n\n* Revision ACL reconstruction\n* Multiligament knee reconstruction\n* Missing or incomplete PROMs or key clinical data","15 Years","50 Years",{"count":90,"type":22},2500,"OBSERVATIONAL","This study looks at two different types of tendon (tissue) used in knee surgery to repair a torn anterior cruciate ligament (ACL), which is a common injury in active people. The two types are taken from different muscles in the thigh: one from the front (quadriceps) and one from the back (semitendinosus). We will use information already collected in a national health registry to see how patients recover after surgery. The study will compare knee function, activity level, and how often patients need another operation.",[94,28,95,96],"Anterior Cruciate Ligament Injury","Ligament Reconstruction","Sports Injuries",[98,99,100,101,102,103,104],"ACL reconstruction","Quadriceps tendon graft","Semitendinosus graft","DKRR","Knee ligament injury","Orthopaedic surgery","Registry study","2025-05-12",{"date":107,"type":37},"2025-05-20",{"date":109,"type":22},"2025-06-01",{"date":111,"type":22},"2025-11-30",{"name":113,"class":44},"Abdirahman Hassan Omar"]