[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"knee-osteoarthristis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:knee-osteoarthristis":25},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,38,0,25,[9,45,75,101,127,162,192,220,244,266,292,313,337,367,390,415,444,467,496,522,547,573,597,617,639],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100564324","prospective-in-vivo-post-market-safety-and-efficacy-surveillance-registry-of-the-maxx-orthopedics-freedom-total-knee-system-100564324",false,"NCT06627699","Prospective, In-Vivo, Post-Market Safety and Efficacy Surveillance Registry of the MAXX Orthopedics, Freedom Total Knee® System","INCLUSION CRITERIA:\n\nCandidates for this registry must meet ALL of the following criteria:\n\n* Patient is \\> 18 years of age\n* Patient has failed attempts at non-operative conservative therapy\n* Patient has participated in the informed consent process and signed an IRB approved informed consent\n* Patient is scheduled to undergo unilateral or bilateral primary TKA of the knee\n\nEXCLUSION CRITERIA:\n\nCandidates will be excluded from the evaluation if ANY of the following apply:\n\n* Patients with previous TKA, UKA, HTO or knee fusion of the indicated knee\n* Patients that have undergone previous surgery of indicated knee for tumor, trauma or fracture\n* Evidence of active or suspected (systemic or local) infection at time of surgery\n* Other significant disabling problems from the musculoskeletal system than in the knee (i.e.: muscular dystrophy, polio, neuropathic joints)\n* Patients with or having; malignancy - active malignancy, Paget's disease, renal osteodystrophy, immunologically suppressed, sickle cell anemia and systemic lupus erythematosus\n* Patients with neuromuscular or neurosensory deficit\n* Women who are pregnant\n* Prisoner or transient\n* Recent history of known narcotic abuse\n* Any significant psychological disturbance past or present, that could impair the consent process or ability to complete subject self-report questionnaires","ALL","18 Years",{"count":19,"type":20},300,"ESTIMATED","2 Years","OBSERVATIONAL","In an effort to satisfy regulatory requirements for post-market surveillance of product safety and efficacy, a representative sample of patients will be recruited for prospective monitoring.",[25,26],"Knee Osteoarthristis","Total Knee Anthroplasty",[28,29,30,31],"Registry","Primary TKA","Total Knee Arthroplasty","Total Knee Replacement","RECRUITING","2026-06-23",{"date":35,"type":36},"2026-06-26","ACTUAL",{"date":38,"type":36},"2025-11-01",{"date":40,"type":20},"2029-03-01",{"name":42,"class":43},"Maxx Orthopedics Inc","INDUSTRY",2,{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":74},"100641192","study-of-wearable-interventions-for-improving-mobility-of-individuals-with-knee-osteoarthritis-100641192","NCT07652437","Study of Wearable Interventions for Improving Mobility of Individuals With Knee Osteoarthritis","Inclusion Criteria:\n\n* Any gender\n* 21+ years of age\n* Doctor-diagnosed tibiofemoral knee osteoarthritis\n* Self-report knee pain or stiffness on most days of the past month\n* Self-report of difficulty walking due to at least one knee\n* Self-report of restricted walking behavior (not engaging in 150 minutes of moderate walking a week) due to at least in part one knee\n* Able to walk one block without the use of an assistive device (e.g. a cane or walker)\n* Able to engage in a walking activity program with the wearable intervention for approximately 30 minutes using standing or sitting rests as needed\n\nExclusion Criteria:\n\n* Unable to walk at least 10 minutes in the community due to an existing cardiovascular, cardiopulmonary, musculoskeletal, or neurological condition\n* Planning knee, hip, ankle or back surgery within the next 6-months\n* Ankle or hip osteoarthritis\n* Inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis, scleroderma, Lymes Disease, Lupus)\n* Bilateral total knee replacements\n* Use of an assistive device (e.g., walker or cane) in home or in the community\n* Self-reported fall within the past 6-months that resulted in limitations in daily activities\n* Lower extremity\u002Ffoot peripheral neuropathy or other sensory disorders\n* Diagnosed with vestibular or other balance disorder that impact walking\n* Open wounds or active skin irritation on the leg shank\n* Open wounds or active ulcers of either feet\n* Unstable cardiovascular disease\n* Unstable respiratory disease\n* History of past or current deep vein thrombosis\n* Active back pain that limits walking\n* Use of supplemental oxygen to walk",true,"21 Years","100 Years",{"count":55,"type":20},9,"INTERVENTIONAL",[58],"NA","Knee osteoarthritis (OA) affects an estimated 654 million people over age 40 world-wide. In the United States, approximately 16% of adults over the age of 40 have knee OA. Pain, activity limitations and disability are common symptoms. Exercise is widely recommended as a non-invasive, first line strategy for people with knee OA. Yet, less than 1\u002F3 of adults with knee OA meet recommended levels of physical activity, and rates are even lower among people who are overweight. Furthermore, adherence to evidence-based structured programs is poor once the therapeutic support is removed. End stage disease is treated by total joint replacement. Under-active people with knee OA would benefit from general walking activity, even if joint replacement surgery is expected; however, walking is difficult and motivation is low. Thus, people with knee OA encounter a difficult paradox: exercise could help decrease pain and improve function but doing so can be difficult and may not always be possible. There is a tremendous need to address this situation. This is a small device-feasibility study evaluating the Dephy ExoBoot, a wearable powered exoskeleton, in individuals with knee OA. The study assesses whether the device can reliably deliver positive assistance during walking and is tolerated across walking tasks. Additional measures, including changes in knee loading and walking speed with versus without the device, are also collected.",[25],[62,63],"knee osteoarthritis","exoskeleton","2026-06-11",{"date":66,"type":36},"2026-06-17",{"date":68,"type":36},"2025-12-15",{"date":70,"type":20},"2029-07-01",{"name":72,"class":73},"Massachusetts Institute of Technology","OTHER",1,{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":85,"studyType":22,"phases":4,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":74},"100622229","genicular-artery-embolization-for-knee-osteoarthritis-rambo-registry-100622229","NCT07380906","geniculaR Artery eMBolization for Knee Osteoarthritis (RAMBO) Registry","Creation Of a Prospective Registry For Genicular Artery Embolization At The Joint & Vascular Institute","RAMBO","Inclusion Criteria:\n\n* Adults (≥18 years) with symptomatic KOA refractory to medical therapy, referred for GAE.\n\nExclusion Criteria:\n\n* Pregnancy, coagulopathy, severe comorbidities, or inability to consent.",{"count":84,"type":20},1200,"5 Years","The goal of this observational study (prospective registry) is to collect long-term real-world data on the effectiveness and safety of genicular artery embolization (GAE) for knee osteoarthritis in adults aged 18 years or older with symptomatic KOA that has not responded to medical therapy.\n\nThe main questions it aims to answer are:\n\n1. Does GAE lead to sustained improvement in pain (WOMAC, VAS) and quality-of-life scores over 12-36 months?\n2. What patient or procedural factors are associated with better outcomes after GAE?\n\nParticipants will:\n\n* Undergo GAE as part of their routine clinical care.\n* Complete clinical follow-up assessments at 1, 3, 6, 12, 18, 24, and 36 months after treatment, including symptom and quality-of-life questionnaires.\n* Have safety outcomes tracked according to Society of Interventional Radiology guidelines.\n\nThere is no comparison group; results will be analyzed to identify predictors of success and inform best practices for patient selection and treatment.",[25],[62,89,90,91],"embolization","GAE","Genicular Artery Embolization","2026-06-10",{"date":94,"type":36},"2026-06-12",{"date":96,"type":36},"2025-07-16",{"date":98,"type":20},"2030-07",{"name":100,"class":43},"Joint & Vascular Institute",{"id":102,"slug":103,"hasResults":12,"nctId":104,"briefTitle":105,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":56,"phases":110,"briefSummary":112,"conditions":113,"keywords":4,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":74},"100630722","phase-4-pilot-exploration-of-platelet-characterization-of-platelet-rich-plasma-created-by-two-different-systems-100630722","NCT07491367","Pilot Exploration of Platelet Characterization of Platelet Rich Plasma Created by Two Different Systems","PRP-PEPC","Inclusion Criteria:\n\n* Kellgren-Lawrence (KL) Grade 1-3 knee osteoarthritis\n* Symptoms of knee osteoarthritis for at least 3 months before presentation in one knee\n* Will be able to attend and perform physical therapy\n\nExclusion Criteria:\n\n* Received injection therapy for knee osteoarthritis in the past 6 months\n* Have severe arthritis diagnosed in ≥1 major joint by radiology criteria\n* History of septic arthritis\n* Underwent knee surgery for osteoarthritis or osteochondral defects within 1 year before randomization (e.g., autograft or allograft surgery)\n* Have had high tibial osteotomy, partial knee replacement, patellar resurfacing, total knee replacement, or have existing surgical hardware in the knee\n* Received a platelet-rich plasma injection elsewhere in the body within the past 3 months\n* Have a platelet disorder or bleeding disorder\n* Have a rheumatologic disease, autoimmune disorder, immunocompromised status, or active history of cancer\n* Are taking chemotherapy, require regular prednisone, or require regular anti-inflammatory use\n* Are pregnant, breastfeeding, or unwilling to practice birth control during the study\n* If both knees have osteoarthritis and the other knee has KL score equal to or greater than 2.\n* Have uncontrolled illness, physical disability, or other contraindication to aerobic exercise training",{"count":109,"type":20},20,[111],"PHASE4","The investigators would like to study the differences in the quality of Platelet Rich Plasma (PRP) between two different machines in those with knee osteoarthritis. Knee osteoarthritis means your cartilage has been worn down, and it affects your knee joint. Both machines, the APEX Biologix XCELL PRP System and the Emcyte PurePRP Supraphysiologic Concentrating System, are FDA approved, commercially available, and makes PRP. The investigators will check if the platelets in the PRP have different amounts or work differently. The investigators will also assess participants symptoms after the injection and compare the two different preparation systems.",[25,114,115,116],"Cartilage Damage","Platelet Rich Plasma","Platelet Rich Plasma Injection","NOT_YET_RECRUITING","2026-06-08",{"date":120,"type":36},"2026-06-09",{"date":122,"type":20},"2026-07-01",{"date":124,"type":20},"2028-09",{"name":126,"class":73},"University of California, San Francisco",{"id":128,"slug":129,"hasResults":12,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":51,"sex":16,"minAge":135,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":56,"phases":139,"briefSummary":140,"conditions":141,"keywords":149,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":74},"100643382","the-act-on-a-geriatric-5-ms-guided-physical-therapy-intervention-for-knee-osteo-arthritis-in-older-adults-100643382","NCT07640529","The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults.","The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults: A Randomised Control Trial","5Ms\u002FPT\u002FKOA\u002FOA","Inclusion Criteria:\n\n* Prospective participants will be Saudi Nationals\n* aged 60 years or older\n* with a clinical diagnosis of knee osteoarthritis.\n* individuals must be capable of walking 10 meters independently or with an assistive device\n* self-report the ability to tolerate a one-hour assessment session.\n\nExclusion Criteria:\n\n* severe cognitive impairment\n* knee surgery within the past 6 months.\n* diagnosis of rheumatoid arthritis\n* the presence of unstable comorbidities (e.g., uncontrolled hypertension, heart failure, arrhythmia, severe pulmonary disease requiring oxygen, or a cardiac event in the past 6 months).\n* severe joint instability or deformity.\n* unmanaged severe osteoporosis.\n* a recent intra-articular corticosteroid injection (\\\u003C3 months).\n* active cancer treatment within the past 6 months.\n* non-elective hospitalization for a major illness.\n* surgery within the past 6 months.","55 Years","90 Years",{"count":138,"type":20},40,[58],"The study is a Random control trail study conducted at King Khalid University Hospital in Riyadh, Saudi Arabia, focusing on Application of 5 framework in rehabilitation program of knee arthritis. The study will involve a in each group sample of 20 KOA patients, with a 12-month duration. The sample size was estimated using G\\*Power 3.1 software, and the initial power analysis indicated that 40 participants would be required to achieve 80.0% statistical power. The study's participants will be aged between 55 and 80 years, diagnosed with Knee osteoarthritis, without cognitive impairment, knee surgery in the past 6 months, or unstable comorbidities. The study will involve in-person 16 sessions, with the first two lasting approximately one hour and the remaining session 30-45 minutes. The main outcome measures that will be used in this study are Stay Independent Brochure, Iconographical Falls Efficacy Scale (icon-FES), Timed Up and Go, 2-Minute Walk Test, 5 Time Set to Stand Test AND Arthritis Self-Efficacy Scale 8 Item (ASES-8), Patient-Specific Functional Scale (PSFS), and Patient satisfaction level with Physical Therapy service MedRisk. Data will be taken from direct questions to patients, by filling out the questionnaire via Google Form, and through some tests and SPSS will be used for data analysis, with ANOVA Test intervention scores of the outcome measures.",[142,143,144,145,146,147,25,148],"Rehabilitation","Excercise","Geriatric","Physical Therapy","Rehabilitation Exercise","Rehabilitation Outcome","Knee Osteoarthritis",[150,151,152,153],"5Ms","PT","KOA","OA","2026-06-06",{"date":92,"type":36},{"date":157,"type":20},"2026-05-15",{"date":159,"type":20},"2026-10-15",{"name":161,"class":73},"King Saud University",{"id":163,"slug":164,"hasResults":12,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":168,"eligibilityCriteria":169,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":56,"phases":172,"briefSummary":173,"conditions":174,"keywords":175,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":74},"100639644","digitally-supported-short-term-prehabilitation-before-total-knee-replacement-100639644","NCT07621666","Digitally Supported Short-Term Prehabilitation Before Total Knee Replacement","Prehab2Rehab: Digitally Supported Short-Term Prehabilitation Before Total Knee Replacement - A Randomized Controlled Feasibility Trial","P2R-KneeTEP","Inclusion Criteria:\n\nEligibility will be determined during the outpatient consultations at the Medical\n\nCenter in Bad Vigaun. Patients will be screened against the following criteria:\n\n* Age ≥18 years at the time of enrolment.\n* Clinically diagnosed with advanced osteoarthritis and with a medical indication for elective TKR.\n* Either a scheduled surgery or a documented intention to undergo TKR within the recruitment period.\n* Elective surgery is scheduled for at least 14 days after enrolment to allow completion of the 10 to 14-day prehabilitation intervention.\n* Physical ability to safely perform the prescribed exercise program, as confirmed by the treating physician.\n* Willingness to participate in a digitally supported training intervention at either the center or home-based.\n* Sufficient digital literacy and access to internet-enabled devices (smartphone, tablet, or computer).\n* Adequate German language proficiency to follow exercise instructions and study procedures.\n\nExclusion Criteria:\n\nPatients will be excluded if any of the following apply:\n\n* Pregnancy at the time of enrolment.\n* Emergency, revisional, or non-elective surgery.\n* Surgery scheduled less than 14 days after enrolment.\n* Severe physical impairment or medical contraindication to exercise training (e.g., unstable cardiovascular disease, uncontrolled hypertension, acute musculoskeletal injury).\n* Patients with contraindications outlined in the Medizinisches Leistungsprofil (MLP) 2.0 that preclude rehabilitation and\u002For surgery.\n* Participation in another clinical study that could interfere with the intervention or study outcomes.",{"count":171,"type":20},60,[58],"This study evaluates the feasibility of a short-term, digitally supported prehabilitation program for patients scheduled for elective total knee replacement (TKR). Osteoarthritis is a leading cause of disability, and recovery following TKR remains heterogeneous, with a substantial proportion of patients experiencing delayed functional recovery. Prehabilitation may improve perioperative outcomes, but its implementation is often limited by short preoperative time windows.\n\nThe Prehab2Rehab-KneeTEP trial is a single-center, two-arm, randomized controlled feasibility study conducted in Austria. Patients will be randomized (1:1) to either a multimodal video-supported prehabilitation program or usual care. The intervention consists of a 10 to 14-day preoperative exercise program including strength, endurance, coordination, and gait training, supported by a digital application, and is complemented by a digitally supported transition phase after hospital discharge until the start of inpatient rehabilitation.\n\nThe primary objective is to assess feasibility in terms of recruitment, retention, adherence, fidelity, acceptability, and safety. Secondary exploratory outcomes include clinical recovery indicators, functional performance, and patient-reported outcomes assessed across the perioperative pathway.",[25,31],[176,177,178,179,180,181,182],"Prehabilitation","Digital Health","Exercise Therapy","Perioperative Care","Rehabilitation Pathway","Randomised Controlled Trial","Tele-rehabilitation","2026-06-02",{"date":185,"type":36},"2026-06-04",{"date":187,"type":20},"2026-05-20",{"date":189,"type":20},"2027-05-01",{"name":191,"class":73},"Ludwig Boltzmann Institute for Digital Health and Prevention",{"id":193,"slug":194,"hasResults":12,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":12,"sex":16,"minAge":199,"maxAge":200,"enrollmentInfo":201,"targetDuration":4,"studyType":56,"phases":202,"briefSummary":203,"conditions":204,"keywords":205,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":4},"100636207","effect-of-knee-and-heel-off-loader-brace-with-non-weight-bearing-strength-in-knee-osteoarthritis-100636207","NCT07562685","Effect of Knee and Heel Off-Loader Brace With Non Weight Bearing Strength in Knee Osteoarthritis","Effect of Knee and Heel Off-Loader Brace With Non Weight Bearing Strength Training on Pain, Gait Variability, and Functional Outcome in Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Clinically diagnosed KOA with radiographic Kellgren and Lawrence grade II-III, confirmed within the previous six months\n* History of knee pain for at least three months, consistent with chronic KOA\n* Ability to ambulate independently, with or without assistive devices\n* No change in pharmacological management for KOA during the previous three months\n* Ability to understand instructions and complete self reported outcome measures\n* Willingness to participate and provision of written informed consent\n\nExclusion Criteria:\n\n* Severe venous insufficiency or history of deep vein thrombosis\n* Acute inflammatory knee conditions (e.g., septic arthritis, acute synovitis)\n* Rheumatic or systemic inflammatory joint diseases (e.g., rheumatoid arthritis)\n* Traumatic onset of knee pain within the previous six months\n* History of major lower limb injury or surgery requiring rehabilitation within the past year\n* Neurological or neurodegenerative disorders affecting gait or balance, including Parkinson's disease","35 Years","50 Years",{"count":109,"type":20},[58],"The current study is a single-blinded, parallel-group pilot randomized controlled trial involving 20 participants diagnosed with knee osteoarthritis (KOA). The trial will compare the effects of a knee and heel off-loader brace combined with non-weight bearing (NWB) strength training versus a conventional knee off-loader brace combined with NWB strength training. Interventions will be delivered three times per week for four weeks.\n\nThe primary outcome of the study is pain intensity, while secondary outcomes include gait variability and functional outcome. Assessments will be conducted at baseline and after completion of the intervention period. The study will be carried out at the outpatient physiotherapy departments of Kaazi Hospital and Ghurki Trust Hospital, Lahore.\n\nThe hypothesis is that the combination of knee and heel off-loader brace with NWB strength training will result in greater reductions in pain, improved gait variability, and enhanced functional outcomes compared to the conventional knee off-loader brace with NWB strength training.",[25],[206,207,208,209,210],"knee Osteoarthirits","Knee Brace","Offloader Brace","Functional Outcome","Gait Variability","2026-05-24",{"date":213,"type":36},"2026-05-28",{"date":215,"type":20},"2026-05",{"date":217,"type":20},"2026-09",{"name":219,"class":73},"Lahore University of Biological and Applied Sciences",{"id":221,"slug":222,"hasResults":12,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":12,"sex":16,"minAge":227,"maxAge":228,"enrollmentInfo":229,"targetDuration":4,"studyType":56,"phases":231,"briefSummary":232,"conditions":233,"keywords":234,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":74},"100638012","bfr-training-and-knee-osteoarthritis-100638012","NCT07590323","BFR Training and Knee Osteoarthritis","The Impact of Blood-flow-restricted Exercise Training and Pain Education on Pain, Function, Muscle Thickness, and Self-satisfaction in Patients With Knee Osteoarthritis.","Inclusion Criteria:\n\n* Male and female Age ≥ 40years.\n* Clinical and radiographic diagnosis of unilateral knee osteoarthritis KOA (Kellgren-Lawrence grade 2, or 3).\n* Willing to attend 3 supervised sessions\u002Fweek for 8 weeks.\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Peripheral vascular disease, active cancer, lower limb infection, open wound\n* history of intra-articular injections within the last 3 months\n* medical condition that may affect their ability to perform exercise (uncontrolled cardiovascular, or neurological disorders)\n* cognitive and psychiatric disorders","40 Years","70 Years",{"count":230,"type":20},90,[58],"Knee osteoarthritis (KOA) is a chronic, progressive degenerative joint disease characterized by cartilage and bone degeneration, synovial inflammation, and structural changes. Clinically, it presents with pain, morning stiffness, swelling, crepitus, and limited range of motion, leading to functional impairment, gait abnormalities, and reduced quality of life. Globally, KOA affects \\~302 million people. In Saudi Arabia, prevalence rises from 30.8% (ages 46-55) to \\>60% (ages 66-75), with higher rates in older, female, and obese individuals. Key risk factors include aging, female sex, obesity, prior knee injury, and genetics. The condition imposes significant health burdens and socioeconomic costs.\n\nThe International Classification of Functioning, Disability, and Health (ICF) identifies KOA as a major cause of physical disability. Pain, restricted motion, and muscle weakness drive quality-of-life decline. While pharmacological treatments exist, physical therapy interventions (education, exercise, weight loss) are crucial, though their success depends on patient behavioral change.\n\nTraditional biomedical education inadequately addresses chronic pain. Pain neuroscience education (PNE) teaches the biology and physiology of pain, supported by a biopsychosocial assessment. PNE is increasingly used by physiotherapists for chronic pain management.\n\nQuadriceps weakness contributes to functional decline in KOA. Conventional high-load resistance training may exacerbate joint pain; thus, low- to moderate-intensity training is recommended. Blood flow restriction training (BFRT) partially restricts arterial inflow and occludes venous outflow during low-load exercise, originally developed as \"kaatsu training\" in Japan. BFRT is used in rehabilitation and performance training across healthy individuals, athletes, older adults, and hypertensive patients. Factors affecting adaptations include occlusion pressure, type (continuous\u002Fintermittent), exercise intensity, and volume. Low-load resistance with BFRT reduces joint pain and increases muscle strength and mass in older adults, including those with KOA risk factors.\n\nA systematic review of six RCTs on BFRT in KOA patients showed significant pain improvement in four studies, but meta-analysis did not confirm a significant difference. Combining exercise therapy and education is recommended for musculoskeletal pain reduction; pain education alone reduced healthcare spending by 45% over three years. However, physical therapists underutilize pain management approaches, and knowledge gaps remain barriers.\n\nControlled clinical studies on BFRT in KOA are lacking. This randomized trial aims to evaluate whether BFRT, PNE, and standard treatment improve pain, function, muscle thickness, and patient satisfaction in KOA patients.",[25],[235],"osteoarthritis; blood flow restrriction; muscles; pain; function","2026-05-17",{"date":187,"type":36},{"date":239,"type":20},"2026-06-15",{"date":241,"type":20},"2026-12-30",{"name":243,"class":73},"University of Hail",{"id":245,"slug":246,"hasResults":12,"nctId":247,"briefTitle":248,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":12,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":56,"phases":251,"briefSummary":252,"conditions":253,"keywords":254,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":74},"100636567","clinical-outcomes-of-focused-shockwave-therapy-without-adjunct-rehabilitation-compared-to-standard-physical-rehabilitation-in-patients-with-grade-i-iii-knee-osteoarthritis-a-single-blind-randomized-study-100636567","NCT07567365","Clinical Outcomes of Focused Shockwave Therapy Without Adjunct Rehabilitation Compared to Standard Physical Rehabilitation in Patients With Grade I-III Knee Osteoarthritis: A Single-Blind Randomized Study","Inclusion Criteria:\n\n* Patient must have diagnosed OA of the unilateral or bilateral knee(s) sufficient to qualify as grade I, II, or III O.A.\n\nExclusion Criteria:\n\n* Patients without diagnosable or gradable O.A. of the knee or knees.",{"count":171,"type":20},[58],"Clinical Outcomes of Focused Shockwave Therapy Without Adjunct Rehabilitation Compared to Standard Physical Rehabilitation in Patients with Grade I-III Knee Osteoarthritis: A Single-Blind Randomized Study",[25],[148,255,256],"Focused Shockwave","Pulse Wave","2026-04-28",{"date":259,"type":36},"2026-05-05",{"date":261,"type":20},"2027-09-25",{"date":263,"type":20},"2028-09-25",{"name":265,"class":43},"Pulse Wave USA",{"id":267,"slug":268,"hasResults":12,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":4,"eligibilityCriteria":272,"healthyVolunteers":12,"sex":16,"minAge":199,"maxAge":273,"enrollmentInfo":274,"targetDuration":4,"studyType":56,"phases":275,"briefSummary":276,"conditions":277,"keywords":279,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":74},"100620365","hemi-tibial-plateau-osteotomy-combined-with-arthroscopic-repair-for-medial-meniscus-posterior-root-tears-in-varus-knees-100620365","NCT07356674","Hemi-tibial Plateau Osteotomy Combined With Arthroscopic Repair for Medial Meniscus Posterior Root Tears in Varus Knees","Hemi-tibial Plateau Osteotomy Combined With Arthroscopic Repair for Medial Meniscus Posterior Root Tears in Varus Knees: A Single-center, Randomized, Controlled, Open-label, Non-inferiority Study","Inclusion Criteria:\n\n* Age 35 to 75 years, with no restriction on sex.\n* Clinical features suggestive of a medial meniscus posterior root tear, including at least one of the following symptoms: knee locking, clicking, or medial knee pain; and at least one of the following signs: medial joint line tenderness or a positive McMurray test.\n* Varus knee deformity with a varus angle of less than 10 degrees, with the deformity predominantly originating from the tibia (i.e., medial proximal tibial angle less than 87 degrees).\n* Knee MRI demonstrates a medial meniscus posterior root tear.\n* Knee radiographs show narrowing of the medial joint space, and Kellgren-Lawrence grade less than IV.\n* Failure of conservative treatment (e.g., rest, medication, or physical therapy) for more than 1 month.\n* Willing to accept randomization and able to understand and sign the informed consent form.\n* For participants with bilateral deformity, the more severely deformed side will be selected as the operative (study) side.\n\nExclusion Criteria:\n\n* Chronic knee locking (e.g., the participant cannot bend or fully straighten the knee).\n* Kellgren-Lawrence grade IV knee osteoarthritis.\n* Osteoarthritis or other conditions in other joints (e.g., hip or ankle) that may affect assessment of knee function.\n* Known inflammatory diseases or other conditions that may affect knee function, including but not limited to: autoimmune diseases (e.g., rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, systemic lupus erythematosus); crystal-induced arthritis (gout, pseudogout); secondary knee osteoarthritis due to trauma or other diseases; active knee joint infection or a history of knee joint infection; reactive arthritis; systemic cartilage disorders; systemic connective tissue diseases; metabolic bone disease; fracture (acute or subacute fracture within 6 months prior to the screening visit); osteonecrosis; or abnormal inflammatory markers (C-reactive protein or high-sensitivity C-reactive protein at least 2 times the upper limit of normal, or erythrocyte sedimentation rate at least 3 times the upper limit of normal), if judged by the investigator to be unsuitable for participation.\n* Target-knee instability (including but not limited to post-traumatic or congenital laxity) or inadequate ligament reconstruction, as judged by the investigator.\n* Any prior surgery on the target knee or on other joints of the ipsilateral lower limb.\n* Serious cardiac disease; hepatic impairment (aspartate aminotransferase or alanine aminotransferase at least 3 times the upper limit of normal, or total serum bilirubin at least 1.5 times the upper limit of normal); renal impairment (serum creatinine at least 1.5 times the upper limit of normal); other musculoskeletal disorders; malignancy; coagulation disorders; immunodeficiency; or psychiatric disorders, if judged by the investigator to be unsuitable for participation.\n* Body mass index at least 30 kg\u002Fm².\n* Pregnant or breastfeeding women, or participants (including men and women) unwilling to use contraception during the study period.\n* Participation in another clinical study within 3 months prior to enrollment (excluding registry studies).\n* Any other condition that, in the investigator's judgment, makes the participant unsuitable for participation.","75 Years",{"count":109,"type":20},[58],"This is a single-center clinical trial started by the study team. The goal is to compare two surgeries for people who have a varus knee alignment and a tear at the back attachment of the medial meniscus. Researchers want to learn how the newer bone-cut procedure with arthroscopic meniscus repair compares to the standard bone-cut procedure with arthroscopic meniscus repair. Researchers will also track safety and hospital-related costs.\n\nMain questions the study aims to answer:\n\n* At 12 months after surgery, how does the improvement in knee function compare between the newer-surgery group and the standard-surgery group? The study will evaluate preliminary trends in clinical efficacy using the Lysholm knee function score.\n* Do the two groups differ in pain relief, imaging findings, meniscus healing, complications, and hospital stay and preliminary cost-effectiveness? The study plans to enroll about 20 participants at Sun Yat-sen University Eighth Affiliated Hospital (Shenzhen Futian). Participants will be assigned by chance, like drawing lots, in a one-to-one ratio. This is an pilot study with a PROBE (Prospective Randomized Open-label Blinded-Endpoint) design. While participants and surgeons will know which surgery is performed, the research assistant responsible for collecting patient-reported outcomes will be blinded to group allocation to minimize observer bias.\n\nStudy groups:\n\n* Experimental group: hemi-tibial plateau osteotomy plus arthroscopic meniscus repair.\n* Control group: high tibial osteotomy plus arthroscopic meniscus repair.\n\nWho may join:\n\n* Age 35 to 65 years, with no restriction on sex;\n* Diagnosed with a medial meniscus posterior root tear;\n* Presence of varus knee deformity;\n* Imaging findings support the diagnosis (e.g., knee MRI);\n* Failure of conservative treatment: no meaningful improvement after more than 1 month of non-surgical management (e.g., rest, medication, or physical therapy);\n* Varus alignment angle less than 10 degrees;\n* The deformity is predominantly tibial in origin;\n* Knee radiographs do not show the most severe osteoarthritis (Kellgren-Lawrence grade other than IV).\n\nWho cannot join:\n\n* A knee that is chronically \"locked,\" meaning it cannot bend or straighten normally.\n* The most severe level of knee arthritis on knee X-ray.\n* Severe arthritis in the hip or ankle that could affect knee function testing.\n* Inflammatory or infectious conditions that can affect the knee, or abnormal inflammation blood tests that make participation unsafe.\n* Knee instability or poorly functioning prior ligament reconstruction, based on the study doctor's judgment.\n* Any prior surgery on the target knee, or on other joints of the same-side lower limb.\n* Serious heart, liver, or kidney disease, cancer, bleeding disorders, immune deficiency, or severe mental health conditions that make participation unsafe.\n* Body mass index of 30 or higher.\n* Pregnancy or breastfeeding, or not willing to use birth control during the study.\n* Participation in another clinical study within the past 3 months (except registry studies).\n* Any other reason the study doctor believes makes participation unsafe or not appropriate.\n\nWhat participants will do:\n\n* Complete screening and baseline assessments within about 30 days before surgery and sign informed consent.\n* Receive the assigned surgery during the hospital stay.\n* Return for follow-up visits at 3 months, 6 months, and 12 months after surgery.\n* Complete knee function and symptom questionnaires and rate pain at each follow-up visit.\n* Have standing knee X-rays and full-length leg X-rays at 3, 6, and 12 months.\n* Have an MRI of the operated knee at 3, 6, and 12 months to assess meniscus healing and meniscus extrusion.\n\nOutcomes:\n\n* Primary outcome: change from baseline to 12 months in the Lysholm knee function score.\n* Secondary outcomes: changes in the Lysholm score at 3 and 6 months; changes in the WOMAC knee arthritis symptom score at 3, 6, and 12 months; changes in pain rating on a standard pain scale at 3, 6, and 12 months; imaging measures and bone healing on X-rays; meniscus healing and extrusion on MRI; surgery time and blood loss; complications during and after surgery; length of hospital stay and hospital costs; and quality of life utility value from a standard health questionnaire.",[25,278],"Meniscus Injury",[280,281,282,283],"Hemi-tibial plateau osteotomy","High tibial osteotomy","Medial meniscus posterior root tears","Varus knees",{"date":285,"type":36},"2026-05-04",{"date":287,"type":36},"2026-03-01",{"date":289,"type":20},"2028-12-31",{"name":291,"class":73},"Eighth Affiliated Hospital, Sun Yat-sen University",{"id":293,"slug":294,"hasResults":12,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":298,"eligibilityCriteria":299,"healthyVolunteers":12,"sex":16,"minAge":227,"maxAge":228,"enrollmentInfo":300,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":302,"conditions":303,"keywords":4,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":311,"locationsCount":74},"100630389","the-efficacy-and-safety-of-a-single-dose-hyaluronic-acid-injection-in-the-treatment-of-knee-osteoarthritis-100630389","NCT07487038","The Efficacy and Safety of a Single-Dose Hyaluronic Acid Injection in the Treatment of Knee Osteoarthritis","Efficacy and Safety of a Single-Dose Hyaluronic Acid Injection in Adults With Symptomatic Knee Osteoarthritis: A Retrospective Study","ESSDHAITKO","Inclusion Criteria:\n\n* Participants who have provided written informed consent.\n* Male and female participants aged 40 to 70.\n* Bilateral or unilateral, painful, primary knee osteoarthritis.\n* Knee pain lasting at least 4 weeks while standing, walking, and\u002For moving, and the presence of at least one of the following features on an X-ray taken within the last 3 months: tibiofemoral osteophytes, femoral or tibial endplate osteosclerosis, or narrowing of the joint space (Kellgren-Lawrence grade 2-3).\n* Baseline Western Ontario and McMaster Universities Arthritis Index (WOMAC) Pain Score (sum of five 100-mm components) between 200 and 400 mm.\n* Individuals deemed by the investigator to be able to adhere to the visit schedule.\n* Discontinuation of all NSAIDs, corticosteroids, and other pain relievers, including over-the-counter medications, herbal treatments, or chondroprotective agents prior to injection, and no use of these during the study follow-up period (except for acetaminophen).\n* Patients who have not received another intra-articular injection in the knee or participated in a physical therapy program during the follow-up period.\n\nExclusion Criteria:\n\n* Participants hospitalized in the hospital.\n* Participants with inflammatory knee conditions other than OA (e.g., rheumatoid arthritis, chronic hemochromatosis, sickle cell anemia, and\u002For chondrocalcinosis, as well as arthropathies associated with systemic diseases such as gout and hemophilia, and infectious joint disease).\n\nThe presence of significant joint effusion identified by the investigator during a clinical examination and confirmed by an ultrasound examination performed on each patient to determine the presence of effusion\n\n* Body mass index (BMI) \\>35 kg\u002Fm²\n* Severe misalignment of the knee axis (i.e., \\>12° severe varus or valgus deformity and\u002For clinically significant moderate to severe instability).\n* Clinical findings of hip osteoarthritis (OA) and\u002For hip joint replacement on the same side as the affected knee. Hip joint replacement on the opposite side of the affected knee is not exclusionary, provided the patient does not have symptomatic hip OA.\n* Surgical intervention on the symptomatic knee within the previous 12 months (including joint replacement) or arthroscopy of the symptomatic knee within the past 3 months (note: joint replacement of the contralateral knee is permitted if performed more than 12 months prior and the participant does not report pain of ≥ 20 mm on the WOMAC pain subscale).\n* Intra-articular (IA) injections in both knees within the past 4 weeks (e.g., corticosteroids, chondroprotective agents).\n* Changes to current medications or the addition of new medications to treat knee OA within the past 4 weeks (i.e., a change in dose or regimen lasting at least 4 weeks).\n* Regular use of opioid pain relievers for pain management. Use of long-acting pain relievers such as analgesic patches, methadone, and levorphanol at any time",{"count":301,"type":20},133,"HA therapy typically consists of several intra-articular injections administered at weekly intervals. A single-dose IA-HA treatment offers patients and physicians a treatment option that involves both lower costs and fewer clinic visits. Furthermore, considering the administration procedure, we believe that single-dose therapy helps reduce the risk of potential side effects.\n\nIn light of this information, our study aims to retrospectively evaluate the efficacy and safety of HA in patients with symptomatic knee OA who have received a single-dose intra-articular HA injection.",[25,304],"Hyaluronic Acid","2026-04-24",{"date":307,"type":36},"2026-04-29",{"date":309,"type":20},"2026-05-01",{"date":157,"type":20},{"name":312,"class":73},"Fatih Sultan Mehmet Training and Research Hospital",{"id":314,"slug":315,"hasResults":12,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":319,"eligibilityCriteria":320,"healthyVolunteers":12,"sex":16,"minAge":321,"maxAge":322,"enrollmentInfo":323,"targetDuration":4,"studyType":56,"phases":325,"briefSummary":326,"conditions":327,"keywords":4,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":334,"leadSponsor":335,"locationsCount":4},"100634257","knee-osteoartritis-genicular-nerve-rf-ablation-vs-alcohol-neurolysis-100634257","NCT07537335","Knee Osteoartritis Genicular Nerve RF Ablation vs Alcohol Neurolysis","Comparison of Genicular Nerve Radiofrequency Ablation and Neurolytic Alcohol Injection for Chronic Knee Osteoarthritis Pain: A Randomized Controlled Trial","GEN-AL-RF","Inclusion Criteria:\n\n* Age: Patients aged 45 to 85 years.\n* Diagnosis: Chronic knee pain for at least 6 months diagnosed with knee osteoarthritis according to American College of Rheumatology (ACR) criteria.\n* Radiological Grade: Grade 3 or 4 according to the Kellgren-Lawrence (K-L) classification.\n* Pain Severity: Baseline Numerical Rating Scale (NRS) score of 5 or higher.\n* Failure of Conservative Treatment: Inadequate response to conservative treatments (e.g., physical therapy, NSAIDs, or intra-articular injections) for at least 3 months.\n* Positive Diagnostic Block: At least 50% reduction in pain for minimum 24 hours following a prognostic genicular nerve block with local anesthetic.\n\nExclusion Criteria:\n\n* Previous Surgery: History of knee arthroplasty or major knee surgery on the affected side.\n* Specific Conditions: Presence of inflammatory arthritis (e.g., rheumatoid arthritis), gouty arthritis, or active infection at the injection site.\n* Neurological Deficit: Severe neurological or psychiatric disorders that may interfere with pain assessment.\n* Coagulopathy: Uncontrolled bleeding disorders or use of anticoagulant therapy that cannot be temporarily discontinued.\n* Recent Injections: Intra-articular steroid or hyaluronic acid injection within the last 3 months.\n* Allergy: Known allergy to local anesthetics, contrast agents, or ethyl alcohol.\n* Pacemaker: Presence of a cardiac pacemaker or implanted electronic device (specifically for the RFA group).","45 Years","80 Years",{"count":324,"type":20},50,[58],"The GEN-AL-RF study is a randomized controlled trial designed to compare the clinical efficacy of two interventional techniques for managing chronic knee pain due to osteoarthritis. The study focuses on genicular nerve radiofrequency (RF) ablation versus neurolytic alcohol injection for pain blockade.\n\nPatients diagnosed with knee osteoarthritis are randomly assigned to either the RF ablation group or the neurolytic alcohol group. The primary objective is to evaluate the superiority and duration of analgesic effects between these two methods. Clinical outcomes are assessed at baseline and at 1, 3, and 6 months post-procedure using the Numeric Rating Scale (NRS) for pain intensity, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for physical function, and the Short Form-12 (SF-12) for health-related quality of life.\n\nThe results of this study aim to provide high-quality evidence regarding the comparative effectiveness and long-term outcomes of genicular nerve RF and alcohol neurolysis in the clinical management of chronic knee osteoarthritis pain.",[25,328,329],"Radiofrequency Ablation","NEUROLYSIS","2026-04-10",{"date":332,"type":36},"2026-04-17",{"date":309,"type":20},{"date":241,"type":20},{"name":336,"class":73},"Sakarya University",{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":343,"eligibilityCriteria":344,"healthyVolunteers":12,"sex":16,"minAge":227,"maxAge":4,"enrollmentInfo":345,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":347,"conditions":348,"keywords":350,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":74},"100603734","transarterial-microembolization-tame-in-inflammatory-knee-pathology-100603734","NCT07140367","\"Transarterial Microembolization (TAME) in Inflammatory Knee Pathology\"","\"Transarterial Microembolization (TAME) in Inflammatory Knee Pathology: Prospective Observational Study.\"","TAME-OA","Inclusion Criteria:\n\n\\- Patients with degenerative knee disease:\n\n1. Age over 40 years;\n2. Moderate knee OA (grade 2-3 according to the Kellgren-Lawrence score) for which an indication for total knee arthroplasty surgery has already been given;\n3. Knee OA with an inflammatory component (night pain, pain at rest, recurrent episodes of effusion, swelling and\u002For redness);\n4. Persistent and moderate or severe knee pain (VAS score \\> 4);\n5. Failure after at least 3 months of conservative therapies (e.g., physical therapy, drug therapy with NSAIDs and pain relievers, hyaluronic acid infiltration, corticosteroids, or orthobiologics).\n6. Signature of informed consent\n7. Case declared eligible for treatment following discussion at internal multidisciplinary meeting on degenerative-inflammatory disease\n\nExclusion Criteria:\n\n1. Mentally incompetent patients;\n2. Patients with trauma in the 6 months prior to treatment;\n3. Patients with malignant neoplasms;\n4. Patients with rheumatic diseases;\n5. Patients on anticoagulant-antiaggregant therapy (including if therapy can be discontinued 5 days earlier);\n6. Patients abusing alcoholic beverages, drugs, or medications;\n7. Patients undergoing surgery of the affected knee in the previous 12 months;\n8. INR \\\u003C2;\n9. Platelet count \\\u003C30,000;\n10. Renal function: GFR\\\u003C30ml\u002Fmin;\n11. Pregnancy;\n12. Allergy to iodinated contrast.\n13. Ineligibility to perform MRI examination.",{"count":346,"type":20},43,"Patients with knee OA and chronic pain refractory to at least 3 months of conventional conservative therapy will be included in the study, which will evaluate the clinical results obtained after treatment with selective arterial embolization (selection and enrollment, treatment with selective arterial embolization, follow-up checks). Forty-three patients will be included in the study and will undergo the transarterial microembolization procedure after signing the informed consent form for participation in the study and the collection of anamnestic data. Subsequently, patients will be followed up with clinical evaluation at 1, 3, 6, 12, and 24 months of follow-up or until possible dropout for other treatment.",[349,25],"Inflammatory Articular Diseases",[89,351,352,353,354,355,356,357],"transarterial microembolization","TAME","arthritis","inflammatory articular disease","arthropathy","knee","osteoarthritis","2026-04-01",{"date":360,"type":36},"2026-04-07",{"date":362,"type":36},"2025-09-01",{"date":364,"type":20},"2031-09-01",{"name":366,"class":73},"Istituto Ortopedico Rizzoli",{"id":368,"slug":369,"hasResults":12,"nctId":370,"briefTitle":371,"officialTitle":372,"acronym":4,"eligibilityCriteria":373,"healthyVolunteers":12,"sex":16,"minAge":321,"maxAge":4,"enrollmentInfo":374,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":376,"conditions":377,"keywords":378,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":388,"locationsCount":74},"100624955","the-validity-and-reliability-of-the-omeract-in-the-turkish-population-100624955","NCT07416357","The Validity and Reliability of the OMERACT in the Turkish Population","The Validity, Reliability, and Clinical Correlation Study of the OMERACT Knee Osteoarthritis Ultrasound Scoring System in the Turkish Population","Inclusion Criteria:\n\n* Adults aged 45 years and older\n* Patients diagnosed with knee osteoarthritis clinically or radiographically\n* Being in a clinical condition that allows tolerance of ultrasound evaluation of both knees\n* Being able to provide written informed consent for participation in the study\n* Having sufficient cognitive ability to understand Turkish forms and scales\n\nExclusion Criteria:\n\n* Diagnosis of inflammatory arthritis (rheumatoid arthritis, psoriatic arthritis, gout, CPPD, etc.)\n* Intra-articular injection into the knee joint within the last 6 months (corticosteroid, hyaluronic acid, PRP, etc.)\n* Previous major knee surgery (total knee replacement, major ligament reconstruction, etc.)\n* Acute pathology that has developed within the last 6 weeks, such as acute trauma\u002Ffracture\u002Fligament injury\n* Severe deformity or severe movement restriction that technically prevents ultrasound examination\n* Active infection\u002Fsystemic febrile condition\n* Neurological disease causing motor or sensory deficit in the lower extremities\n* Use of Gabapentinoid\u002FSNRI\u002FSSRI due to fibromyalgia or psychiatric illness\n* Severe cognitive impairment or communication problems that would prevent participation in the study\n* Pregnancy\n* Subjects who have been informed about the study and refuse to participate",{"count":375,"type":20},100,"Knee osteoarthritis is a chronic disease common in middle-aged and older adults, characterized by functional impairment and reduced quality of life due to pain. While physical examination and radiographic Kellgren-Lawrence grading are frequently used in clinical evaluation, the severity of pain does not always correlate with the degree of structural degeneration. Ultrasonography is gaining prominence in osteoarthritis research due to its advantage of simultaneously evaluating both inflammatory and structural components, such as synovial hypertrophy, effusion, power Doppler signal, and osteophytes. The Outcome Measures in Rheumatology (OMERACT) working group has developed a standardized, multidimensional ultrasound scoring system for knee osteoarthritis, and this method is frequently used in the literature. This method consists of a diagnostic ultrasound examination lasting approximately 8-10 minutes. The examination evaluates the anatomical structures of the knee and also includes soft tissue examinations such as synovial hypertrophy. With this method, a diagnostic ultrasound examination lasting approximately 8-10 minutes is performed. The examination evaluates the anatomical structures of the knee and also includes soft tissue examinations such as synovial hypertrophy. Considering the differences between societies in cultural, genetic, biomechanical, body mass index distribution, and healthcare system practices, direct validity, clinical interpretability, and inter-study comparability are of significant importance. The validity, reliability, and applicability of the OMERACT osteoarthritis ultrasound scoring system have been reported in a study conducted on the Egyptian population. However, there is no data on the validity and reliability of OMERACT ultrasound scoring in the Turkish population. This study is the first prospective validation study aimed at establishing standardization for use in clinical practice in Turkey.",[25],[379,380,356],"ostheoarthritis","ultrasonography","2026-03-23",{"date":383,"type":36},"2026-03-27",{"date":385,"type":36},"2026-02-01",{"date":387,"type":20},"2027-09-01",{"name":389,"class":73},"Izmir Democracy University",{"id":391,"slug":392,"hasResults":12,"nctId":393,"briefTitle":394,"officialTitle":395,"acronym":4,"eligibilityCriteria":396,"healthyVolunteers":12,"sex":16,"minAge":227,"maxAge":397,"enrollmentInfo":398,"targetDuration":4,"studyType":56,"phases":400,"briefSummary":401,"conditions":402,"keywords":403,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":74},"100623882","blood-flow-restriction-training-in-knee-osteoarthritic-patients-100623882","NCT07402408","Blood Flow Restriction Training in Knee Osteoarthritic Patients","Comparison of Band Tissue Flossing Method and Traditional Cuff Method for Blood Flow Restriction Training in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Age 40-60 years\n* Pain more than or equal to 3 on NPRS\n* Range of motion ≤ 100-degree flexion and ≤ 0-degree extension\n* Those who have knee osteoarthritis, according to KL (Grade 1 and 2)\n* Genders: Male and Female\n\nExclusion Criteria:\n\n* Cardiovascular condition e.g., hypertension, thromboembolism, lymphatic diseases etc.\n* Muscle\u002Ftendon\u002F ligament injuries\n* Any surgery, skin infection, trauma, pregnancy, fracture and fall\n* Patient with intra articular steroidal therapy with in last 6 months\n* Patient unwilling to participate and comply with the study session","60 Years",{"count":399,"type":20},46,[58],"The aim of this study was to compare the effect of band tissue flossing method and traditional cuff method for blood flow restriction training on pain, range of motion, muscle strength and functional status in patients with knee osteoarthritis. Symptoms of this condition limit patient's ability to perform high load strengthening. Blood flow restraining training allows strengthening with lower loads. 46 subjects will be divided in two groups, 23 subjects in each group. knee extension and knee press exercises will be performed. In group A floss band was tied on thigh and in group B pneumatic cuff was applied on thigh. 40-60 years individual with knee osteoarthritis will be included. outcome measures will be assessed at baseline, after 1st session, after 2nd week and after 4th week.",[25],[404,148,405],"Blood flow restriction therapy","Range of Motion","2026-03-16",{"date":408,"type":36},"2026-03-17",{"date":410,"type":20},"2026-03",{"date":412,"type":20},"2026-06-25",{"name":414,"class":73},"Riphah International University",{"id":416,"slug":417,"hasResults":12,"nctId":418,"briefTitle":419,"officialTitle":420,"acronym":421,"eligibilityCriteria":422,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":423,"targetDuration":4,"studyType":56,"phases":425,"briefSummary":426,"conditions":427,"keywords":430,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":440,"leadSponsor":442,"locationsCount":74},"100583759","comparing-articular-noise-and-its-perception-between-two-different-types-of-total-knee-arthroplasty-100583759","NCT06880497","Comparing Articular Noise and Its Perception Between Two Different Types of Total Knee Arthroplasty","Monocentric, Randomized Study, Comparing Articular Noise and Its Perception Between Two Different Types of Total Knee Arthroplasty","NATKA","Inclusion Criteria:\n\n* Adult patients receiving a primary TKA\n* Signed informed consent\n* Patients affiliated to a social security scheme\n* Patients willing and able to comply with study protocol requirements based on the investigator's judgment.\n\nExclusion Criteria:\n\n* History of knee surgery on the concerned\u002Fstudied knee (except arthroscopic surgery)\n* Patients presenting coronal deformities \\> 20°, varus laxity \\> 10° and\u002For valgus laxity \\> 15°\n* Patients receiving revision TKA\n* Pregnancy or breast-feeding\n* Patients with protected status under articles L1121-6, LL121-8 and L1122-2 of the French Public Health Code\n* Unable to comply with study procedures, based on the investigator's judgment.",{"count":424,"type":20},170,[58],"Some patients complain of articular noise (such as clicking, snapping, cracking or popping) after a total knee replacement. Controversy remains about whether there is a correlation between articular noise and worse outcomes following a knee replacement. A study by Nam et al. on 1540 patients revealed an association between noise and residual symptoms 30 days after they received a total knee replacement. Conversely, a study by Kuriyama et al. on 60 patients revealed no correlation between noise and patient satisfaction after 1 year of receiving a total knee replacement. The incidence of noise following a knee replacement has rarely been studied as a primary outcome. Like pain, it could be considered an important patient-reported outcome to assess patient satisfaction. The study aims to compare the prevalence of patient-perceived noise of an ultra-congruent total knee prosthesis (Score 2, Amplitude) versus a posterior-stabilized total knee prosthesis (Anatomic, Amplitude).",[25,428,429],"Knee Replacement Arthroplasty","Knee Replacement, Total",[431,432,30,433,31,434],"Noise","Articular noise","TKA","TKR","2026-03-02",{"date":437,"type":36},"2026-03-04",{"date":439,"type":36},"2025-12-24",{"date":441,"type":20},"2028-12",{"name":443,"class":73},"Elsan",{"id":445,"slug":446,"hasResults":12,"nctId":447,"briefTitle":448,"officialTitle":449,"acronym":4,"eligibilityCriteria":450,"healthyVolunteers":12,"sex":16,"minAge":321,"maxAge":273,"enrollmentInfo":451,"targetDuration":4,"studyType":56,"phases":452,"briefSummary":453,"conditions":454,"keywords":455,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":44},"100625739","close-chain-and-open-chain-exercises-with-blood-flow-restriction-in-knee-osteoarthritis-100625739","NCT07426549","Close Chain and Open Chain Exercises With Blood Flow Restriction in Knee Osteoarthritis","Comparison of Close Chain and Open Chain Exercises With Blood Flow Restriction in Knee Osteoarthritis","Inclusion Criteria:\n\n* Radiologic confirmation of KOA demonstrating Kellgren-Lawrence grade 1 or 2.\n* Exhibited symptoms of unilateral KOA.\n* Not taking any medications for KOA or receiving other treatments (including physiotherapy).\n* Willing to participate without any neurological symptoms were the main objects of study.\n\nExclusion Criteria:\n\n* A history of knee surgery or scheduled surgery.\n* Kellgren-Lawrence grade 3 or 4.\n* Systolic blood pressure over 160 mm Hg or under 100 mm Hg.\n* Use of nonsteroidal anti-inflammatory drugs in the past 3 months.\n* Any known vascular disease or any diagnosed blood pathology.\n* Concomitant symptomatic hip or ankle pathology that could influence knee pain or function.",{"count":138,"type":20},[58],"The aim of this research is to find and compare the effect of close chain and open chain exercises with blood flow restriction in knee osteoarthritis on pain, range of motion, strength and functional performance in patients with knee osteoarthritis. Randomized controlled trials done at Railway General Hospital and Medistic Medical and Dental Center, Rawalpindi. The sample size was 40. The subjects were divided in two groups, 20 subjects in close chain exercises with blood flow restriction group and 20 in open chain exercises with blood flow restriction group. Study duration was of 4 weeks. Sampling technique applied was purposive non probability sampling technique. Only 45-75 years individual with grade 1 or 2 knee osteoarthritis were included. Tools used in the study are Numeric pain rating scale (NPRS), Western Ontario and McMaster Universities Arthritis Index (WOMAC), goniometer, crane scale (dynamometer), 30 s chair stand test. Data was analyzed through SPSS 21.",[25],[148,456,457,458],"Blood Flow Restriction","Blood Flow Resriction Therapy","Knee Joint","2026-02-17",{"date":461,"type":36},"2026-02-23",{"date":463,"type":20},"2026-02-28",{"date":465,"type":20},"2026-06-30",{"name":414,"class":73},{"id":468,"slug":469,"hasResults":12,"nctId":470,"briefTitle":471,"officialTitle":471,"acronym":4,"eligibilityCriteria":472,"healthyVolunteers":12,"sex":16,"minAge":227,"maxAge":397,"enrollmentInfo":473,"targetDuration":4,"studyType":56,"phases":475,"briefSummary":476,"conditions":477,"keywords":480,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":492,"leadSponsor":494,"locationsCount":44},"100623407","effects-of-diagonal-proprioceptive-neuromuscular-facilitation-patterns-on-pain-and-functional-outcomes-in-patients-with-knee-osteoarthritis-100623407","NCT07396233","Effects of Diagonal Proprioceptive Neuromuscular Facilitation Patterns on Pain and Functional Outcomes in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Both male and females with an age range between 40-60 years.\n* Patients diagnosed with unilateral or bilateral Knee OA.\n* Grade-II or grade-III on kellgren and Lawrence classification.\n* Patients having pain intensity more than 3.4 cm on VAS as minimum cut off value.\n* Duration of knee OA more than 3 months (chronic).\n\nExclusion Criteria:\n\n* Patients with any neurological disorder.\n* History of lower limb arthroplasty or any other knee surgery.\n* Septic knee arthritis.\n* Inflammatory rheumatic disease such as rheumatoid arthritis and gout.\n* Cancer or any other malignancy such as bone tumor.\n* Knee deformities such as contracture, genu valgum and genu varum.\n* History of ligamentous injury and meniscal tear.",{"count":474,"type":20},150,[58],"A randomized controlled trial will be conducted at the Department of Physiotherapy, Dr. Ziauddin Hospital and Al-Rayaz Hospital, Karachi, Pakistan. A total of 150 patients diagnosed with knee osteoarthritis, aged between 40-60 years, will be recruited through a non-probability purposive sampling technique. Written informed consent will be obtained from all eligible participants prior to enrollment. The participants will be randomly allocated by the help of computer generated randomization sheet, into two groups i.e. experimental and the control group, with 75 participants in each group. Group A (experimental group) will receive diagonal proprioceptive neuromuscular facilitation (PNF) pattern exercises, while Group B (control group) will receive conventional strength training exercises. Heat therapy will be administered to both groups. All participants will be assessed using a standardized assessment form. Outcome measures will include pain intensity, knee range of motion, functional disability, hamstring flexibility, dynamic balance, and fatigue level. A single blinded assessor will assess all participants at baseline and at post intervention. Treatment sessions will be given thrice a week on alternate days for 6 weeks.",[25,478,479],"Osteearthritis","Knee Pain Arthritis",[148,481,482,483,484,485,486,487],"Functional Disability","Knee Pain","Conventional Training","Osteoarthritis","Arthritis","Musculoskeletal Disease","Joint Disease","2026-02-07",{"date":490,"type":36},"2026-02-11",{"date":488,"type":36},{"date":493,"type":20},"2027-02-22",{"name":495,"class":73},"University of Karachi",{"id":497,"slug":498,"hasResults":12,"nctId":499,"briefTitle":500,"officialTitle":501,"acronym":502,"eligibilityCriteria":503,"healthyVolunteers":12,"sex":16,"minAge":321,"maxAge":504,"enrollmentInfo":505,"targetDuration":4,"studyType":56,"phases":506,"briefSummary":507,"conditions":508,"keywords":509,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":513,"lastUpdatePostDateStruct":514,"startDateStruct":516,"completionDateStruct":518,"leadSponsor":520,"locationsCount":74},"100581962","feasibility-of-resting-intervals-during-exercise-programs-for-individuals-with-knee-osteoarthritis-100581962","NCT06857123","Feasibility of Resting Intervals During Exercise Programs for Individuals With Knee Osteoarthritis","Mechanical and Molecular Determinants of Cartilage Response to Exercise","CaRE","Inclusion Criteria:\n\n* Age between 45 and 79 yo.\n* Clinical diagnosis of primary, early to moderate stage knee osteoarthritis.\n* BMI range \\\u003C 35 kg\u002Fm2.\n* Sedentary lifestyle\n* Knee joint is the most painful joint in the body.\n* Ability to speak and understand English.\n* Willingness to comply with all study procedures and be available for the duration of the study.\n\nExclusion Criteria:\n\n* Non-OA disease of the knee.\n* Advanced knee osteoarthritis\n* Knee injection in the past 3 months.\n* Major knee trauma\u002Fsurgery in the past 5 years or previous knee surgery with hardware limiting cartilage assessment..\n* Participate in regular exercise or physical activity .\n* Participation in an intervention study for knee OA.\n* Currently using a cane, walker or crutches to walk.\n* History of cardiovascular disease or hypertension not controlled by medication.\n* Two or more unexplained falls in the past year.\n* Inflammatory, autoimmune disorders, neurological, systemic, muscular, or connective tissue conditions that affect walking or ability to exercise.\n* Contraindication to MRI.\n* Medical condition or characteristic of the participant that could place the individual at increased risk or preclude s\u002Fhe from complying with study procedures.\n* Pregnant female.\n* Acute or terminal illness.","79 Years",{"count":109,"type":20},[58],"This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis. One group receives the exercise program administered as usual, and the other group received the exercise program with resting intervals.",[25],[510,484,511,512],"Knee","exercise","feasibility","2026-02-04",{"date":515,"type":36},"2026-02-09",{"date":517,"type":36},"2024-12-04",{"date":519,"type":20},"2026-12-31",{"name":521,"class":73},"University of Pittsburgh",{"id":523,"slug":524,"hasResults":12,"nctId":525,"briefTitle":526,"officialTitle":527,"acronym":4,"eligibilityCriteria":528,"healthyVolunteers":12,"sex":16,"minAge":227,"maxAge":228,"enrollmentInfo":529,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":531,"conditions":532,"keywords":533,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":537,"lastUpdatePostDateStruct":538,"startDateStruct":540,"completionDateStruct":542,"leadSponsor":544,"locationsCount":74},"100621169","neuropathic-pain-in-knee-osteoarthritis-pain-severity-and-functional-status-100621169","NCT07367126","Neuropathic Pain in Knee Osteoarthritis: Pain Severity and Functional Status","Presence of Neuropathic Pain in Knee Osteoarthritis: Relationship Between Pain Severity and Functional Status","Inclusion Criteria:\n\n* Diagnosed with Knee OA according to ACR criteria.\n* Knee pain for more than 3 months.\n* Voluntary participation.\n\nExclusion Criteria:\n\n* History of surgical intervention in the affected knee.\n* History of trauma to the affected knee within the last 6 months.\n* History of intra-articular injections (e.g., corticosteroids, hyaluronic acid, PRP) or physical therapy involving the affected knee within the last 6 months.\n* Presence of severe psychiatric disorders such as severe depression, anxiety disorder, or psychosis.\n* Diagnosis of central nervous system diseases, including Parkinson's disease or multiple sclerosis.\n* Diagnosis of inflammatory arthritis, such as Rheumatoid Arthritis or Ankylosing Spondylitis.\n* Severe cognitive impairment.\n* Chronic decompensated cardiac, renal, or hepatic failure.\n* Severe psychiatric, neurological, or kognitive disorders.\n\nDecompensated cardiac, renal, or hepatic failure.",{"count":530,"type":20},102,"Osteoarthritis (OA) is a degenerative joint disease characterized by structural changes such as cartilage loss and osteophyte formation, leading to functional limitations and disability. Pain in knee OA involves a complex pathophysiological structure including both nociceptive and neuropathic mechanisms. Identifying the neuropathic pain component is clinically significant for improving quality of life and functional recovery. This cross-sectional controlled clinical study aims to determine the prevalence of neuropathic pain in patients with knee OA and evaluate its impact on pain severity and functional status. Patients will be categorized based on the Douleur Neuropathique 4 (DN4) questionnaire and assessed using various pain and functional scales.",[25],[534,535,536,148],"Pain Intensity","Functional Status","Neuropathic Pain","2026-01-17",{"date":539,"type":36},"2026-01-26",{"date":541,"type":36},"2025-12-20",{"date":543,"type":20},"2026-04-30",{"name":545,"class":546},"Istanbul Physical Medicine Rehabilitation Training and Research Hospital","OTHER_GOV",{"id":548,"slug":549,"hasResults":12,"nctId":550,"briefTitle":551,"officialTitle":551,"acronym":4,"eligibilityCriteria":552,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":553,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":555,"conditions":556,"keywords":560,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":565,"lastUpdatePostDateStruct":566,"startDateStruct":568,"completionDateStruct":570,"leadSponsor":571,"locationsCount":74},"100619684","molecular-mechanisms-underlying-hip-and-knee-osteoarthritis-in-patients-undergoing-primary-elective-arthroplasty-100619684","NCT07347821","Molecular Mechanisms Underlying Hip and Knee Osteoarthritis in Patients Undergoing Primary Elective Arthroplasty","Inclusion Criteria:\n\n* 18 years old and more\n* patient qualified for primary TKA or primary THA\n* patient diagnosed with hip or knee osteoarthritis\n* a complete set of tissues of good quality and volume is available\n* does not meet the exclusion criteria.\n\nExclusion Criteria:\n\n* lack of written consent to participate in the study or surgery\n* any private or professional relationship with the Investigators\n* genetic connective tissue diseases (e.g., Ehlers-Danlos syndrome and others)\n* genetic metabolic diseases (e.g., gout and others)\n* genetic diseases affecting the anatomy of the operated joint (e.g., dysplasia and others)\n* previous surgeries altering the anatomy of the examined joint (e.g., periacetabular osteotomy, unicompartmental endoprosthesis, and others)\n* patients undergoing revision after THA\u002FTKA\n* autoimmune diseases in the patient's medical history\n* traumatic injury to the hip or knee joint\n* previous participation in the study.",{"count":554,"type":20},1000,"The aim of this observational study is to determine content of rare metals and other elements, along with the levels of selected immunological parameters, in the tissue of the hip or knee joint in the course of degenerative diseases. Determining potential disturbances in the levels or functions of these parameters may in the future contribute to improving treatment - for example, through supplementation of deficient metals or modulation at the immunological level. The main question it aims to answer is:\n\nAre selected rare metals, trace elements and other selected immunological parameters lowered in the tissue of the hip or knee joint as well as in serum in the course of osteoarthritis?",[557,558,559,25],"Total Hip Arthroplasty (THA)","Total Knee Arthroplasty (TKA)","Hip Osteoarthritis",[31,561,562,484,563,564],"Total Hip Replacement","Trace Elements","Cytokines","Oxidative Stress","2026-01-08",{"date":567,"type":36},"2026-01-16",{"date":569,"type":36},"2025-11-22",{"date":441,"type":20},{"name":572,"class":73},"Medical University of Warsaw",{"id":574,"slug":575,"hasResults":12,"nctId":576,"briefTitle":577,"officialTitle":578,"acronym":579,"eligibilityCriteria":580,"healthyVolunteers":12,"sex":16,"minAge":200,"maxAge":4,"enrollmentInfo":581,"targetDuration":4,"studyType":56,"phases":582,"briefSummary":583,"conditions":584,"keywords":585,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":589,"lastUpdatePostDateStruct":590,"startDateStruct":592,"completionDateStruct":593,"leadSponsor":595,"locationsCount":74},"100618252","femoral-nerve-mobilization-for-patients-with-knee-osteoarthritis-100618252","NCT07329205","Femoral Nerve Mobilization for Patients With Knee Osteoarthritis","Effects of Femoral Nerve Mobilization on Pain Intensity, Function, Quality of Life and Central Sensitization in Patients With Knee Osteoarthritis","RCT","Inclusion Criteria:\n\n* patients aged 50 years or older, diagnosed with KO according to theAmerican College of Rheumatology's criteria with knee pain, and grade I or II on the Kellgren-Lawrence radiographic scale\n\nExclusion Criteria:\n\n* individuals suffering from chronic conditions considered to be perpetuating factors (e.g., fibromyalgia)\n* those with conditions causing lower extremity pain\n* individuals who had taken analgesics within 24 h before evaluations\n* those who had undergone corticosteroid or local anesthetic infiltration in the year prior to the study or during the follow-up period\n* those using substances that could interfere with treatment\n* those with a previous diagnosis of neuropathy (lumbosacral plexus) or myopathy\n* those with contraindications to mobilization or exercise, and those with cognitive deficits (dementia, Alzheimer's).",{"count":324,"type":20},[58],"Background: Knee osteoarthritis (KO) is considered as a cause of disability among the elderly, causing pain, reduced quality of life, and decreased functionality. There is a limited knowledge about using femoral nerve mobilization in treating patients with arthritic changes.\n\nObjectives: This study will be designed to determine the efficacy of adding of femoral nerve mobilization on pain intensity, function, quality of life and central sensitization in patients with knee osteoarthritis Methods: Thirty patients (aged ≥50 years with KO Kellgren-Lawrence grades I-II) will be included in this study: Patients will randomly be assigned into two groups: group A will receive traditional physical therapy while group B will receive femoral nerve mobilization in addition to traditional physical therapy. Three sessions will be performed for four weeks by 3 session \u002Fweek. Patients will be evaluated for pain intensity using the numerical rating scale (NRS), knee function by WOMAC scale, quality of life by 12-item Short Form Survey questionnaire (SF-12) and central sensitization by the Arabic version of central sensitization inventory (CSI).",[25],[586,587,588],"NEURAL MOBILIZATION","Knee osteoarthritis","conventional physical therapy","2025-12-28",{"date":591,"type":36},"2026-01-09",{"date":541,"type":20},{"date":594,"type":20},"2026-02-25",{"name":596,"class":73},"Prince Sattam Bin Abdulaziz University",{"id":598,"slug":599,"hasResults":12,"nctId":600,"briefTitle":601,"officialTitle":602,"acronym":4,"eligibilityCriteria":603,"healthyVolunteers":12,"sex":16,"minAge":227,"maxAge":604,"enrollmentInfo":605,"targetDuration":4,"studyType":56,"phases":606,"briefSummary":607,"conditions":608,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":610,"startDateStruct":611,"completionDateStruct":613,"leadSponsor":615,"locationsCount":74},"100618264","efficacy-and-safety-of-intra-articular-injections-of-frozen-platelet-rich-plasma-in-patients-with-knee-osteoarthritis-100618264","NCT07329361","Efficacy and Safety of Intra-articular Injections of Frozen Platelet-Rich Plasma in Patients With Knee Osteoarthritis","Efficacy and Safety of Intra-articular Injections of Frozen Platelet-Rich Plasma in Patients With Knee Osteoarthritis: Randomized Control Trial","Inclusion Criteria:\n\n* Patients of both sexes.\n* Aged between 40 and 85 years old.\n* Diagnosed with osteoarthritis through clinical radiological examination.\n* Joint pain equal to or less than 75 points on the KOOS (pain).\n* Radiological severity grades 1, 2, and 3 according to the Ahlbäck scale.\n* Indication for intra-articular PRP infiltration.\n* Body Mass Index values between 20 and 35.\n* Negative serological tests for syphilis, HIV, HBV, and HCV.\n* Possibility of observation during the follow-up period.\n* Signature of informed consent.\n\nExclusion Criteria:\n\n* Body mass index \\>35\n* Diagnosed polyarticular disease.\n* Previous arthroscopy in the last year.\n* Severe mechanical deformity.\n* Intra-articular hyaluronic acid injection in the last 12 months.\n* Intra-articular corticosteroid or PRP injection in the last 6 months.\n* Systemic autoimmune rheumatic disease (connective tissue diseases and systemic necrotizing vasculitis).\n* Anemia or other hematological disorders.\n* Positive serological tests for SYPHILIS, HIV, HBV, and HCV.\n* Undergoing immunosuppressive treatments.\n* Poorly controlled diabetes mellitus.\n* Patients allergic to paracetamol.\n* Pregnancy or breastfeeding.","85 Years",{"count":171,"type":20},[58],"Evaluation of intra-articular injections in knee osteoarthritis using frozen-stored PRP. Compared with intra-articular injections of PRP applied at the time of collection.",[25],"2025-12-26",{"date":591,"type":36},{"date":612,"type":20},"2025-12-16",{"date":614,"type":20},"2027-12-31",{"name":616,"class":73},"MiKS Hospital",{"id":618,"slug":619,"hasResults":12,"nctId":620,"briefTitle":621,"officialTitle":622,"acronym":4,"eligibilityCriteria":623,"healthyVolunteers":12,"sex":16,"minAge":200,"maxAge":322,"enrollmentInfo":624,"targetDuration":4,"studyType":56,"phases":626,"briefSummary":627,"conditions":628,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":630,"lastUpdatePostDateStruct":631,"startDateStruct":633,"completionDateStruct":635,"leadSponsor":637,"locationsCount":74},"100617509","accelerated-rehabilitation-in-individuals-after-total-knee-arthroplasty-100617509","NCT07319546","Accelerated Rehabilitation in Individuals After Total Knee Arthroplasty","Effectiveness of Accelerated Rehabilitation on Knee Joint Function and Quality of Life in Individuals With Total Knee Arthroplasty: A Double Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients diagnosed with end-stage knee OA necessitating primary unilateral TKA.\n\nExclusion Criteria:\n\n* History of joint infections, cancer, or inflammatory arthritis.\n* End-stage OA from rheumatoid or septic arthritis.\n* Individuals with neurological disorders such as Alzheimer's disease, - Parkinson's disease, stroke.\n* Individuals who are unable to follow a structured rehabilitation protocol.\n* Previous history of knee surgeries (other than arthroscopy).\n* Severe comorbidities that would hinder participation (e.g., advanced cardiovascular diseases).\n* Individuals who have severe osteoporosis.",{"count":625,"type":20},32,[58],"The primary aim of this double-blind randomized controlled trial is to evaluate the effectiveness of an accelerated rehabilitation protocol on knee joint function and quality of life in individuals undergoing TKA compared to conventional rehabilitation in Dali, Yunan, China. The study will include patients aged 50-80 years who are scheduled for primary unilateral TKA. Participants will be randomly assigned to either an accelerated rehabilitation group or conventional rehabilitation group. The primary outcomes will include knee joint function, assessed using the KOOS and quality of life measures using the SF-36 surveys. The study will follow participants for 6 months post-surgery to assess longer-term outcomes. This study will not include individuals undergoing revision TKA or those with severe comorbid conditions. The results will provide critical insights into the role of accelerated rehabilitation in improving post-operative recovery, functional outcomes, and overall quality of life for TKA patients.",[25,629],"Arthroplasties, Knee Replacement","2025-12-21",{"date":632,"type":36},"2026-01-06",{"date":634,"type":36},"2025-12-01",{"date":636,"type":20},"2027-06-30",{"name":638,"class":73},"Mahidol University",{"id":640,"slug":641,"hasResults":12,"nctId":642,"briefTitle":643,"officialTitle":644,"acronym":4,"eligibilityCriteria":645,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":273,"enrollmentInfo":646,"targetDuration":4,"studyType":56,"phases":648,"briefSummary":649,"conditions":650,"keywords":654,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":661,"lastUpdatePostDateStruct":662,"startDateStruct":664,"completionDateStruct":666,"leadSponsor":668,"locationsCount":44},"100617337","the-ntu-jo-smart-study-100617337","NCT07317310","The NTU JO-SMART Study","Effects of the NTU-JO Smart Program for People With Knee Osteoarthritis and Obesity: a Multicenter Pragmatic Randomized Controlled Trial","Inclusion Criteria:\n\n* Age: 18 to 75 years.\n* Obesity status: body mass index (BMI) ≥ 27 kg\u002Fm², consistent with the obesity definition defined by the Health Promotion Administration, Ministry of Health and Welfare, Taiwan.\n* Diagnosis of KOA in at least one knee according to the American College of Rheumatology (ACR) criteria, with a Kellgren-Lawrence (KL) grade of 1, 2, or 3.\n* Symptomatic disease: defined as a WOMAC pain subscale score (range 0-20) greater than 4 at screening.\n* Sedentary lifestyle: defined as less than 30 minutes of physical activity per week for the past 6 months.\n* Informed consent: willing and able to provide written informed consent and comply with all longitudinal study procedures.\n* Comorbid status: participants may be included regardless of a baseline diagnosis of T2D or CKD. Stratified randomization and subgroup analyses will be conducted based on these baseline conditions.\n\nExclusion Criteria:\n\n* KL grade 4 KOA in either knee.\n* Diagnosis of inflammatory arthritis, such as rheumatoid arthritis or psoriatic arthritis.\n* Knee arthroscopy within the past 3 months or previous surgical history of TKA.\n* Recent receipt of intra-articular injections (e.g., corticosteroids, hyaluronic acid) within the past 3 months.\n* Documented history of osteoporotic fracture in hospital or cloud-based medical records.\n* Type 1 diabetes.\n* Presence of conditions precluding safe participation in an exercise program, such as unstable cardiovascular disease or severe neurological disorders.\n* Participation in another interventional clinical trial within the past 3 months.\n* Engagement in dietary regimens likely to cause significant weight change (e.g., intermittent fasting, such as the 16:8 time-restricted eating) within 1 month prior to trial initiation.\n* Use of any FDA-approved weight-loss medications (e.g., semaglutide, tirzepatide) within 3 months prior to trial initiation.\n* History of any form of surgical treatment for weight loss.\n* Current use of lithium or antipsychotics at a dose equivalent to olanzapine \\>20 mg\u002Fday.\n* Pregnant or breastfeeding women, or women of childbearing potential without adequate contraception.\n* Current malignancy (within the validity period of a catastrophic illness certificate), or any other clinical condition deemed unsuitable for participation by the investigator (investigator discretion).\n* Inability to use smart devices or telecommunication tools due to severe visual\u002Fhearing impairment or lack of internet access.",{"count":647,"type":20},312,[58],"This study recruits patients with coexisting obesity and knee osteoarthritis (KOA) to implement the NTU-JO Smart Program, an innovative intervention integrating AI-assisted community-based exercise with continuous glucose monitoring (CGM). The primary objective is to investigate whether this intervention can improve glycemic control in this comorbid population. Other outcome measures include the risk of total knee arthroplasty (TKA), body weight changes, pain intensity scores, bone mineral density (BMD), cognitive function, as well as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Patient-Reported Outcomes Measurement Information System (PROMIS) scores, which reflect the patients' overall functional status. The project also sought to explore the long-term association of the NTU-JO Smart Program with the development of type 2 diabetes (T2D) and major renal events, thereby facilitating patient-centered early treatment.",[25,651,652,653],"Diabetes (DM)","Obesity & Overweight","Chronic Kidney Disease",[655,656,657,658,659,660],"Diabetes","Chronic kidney disease","Knee osteoarthristis","obesity","Exercise","continuous glucose monitoring","2025-12-18",{"date":663,"type":36},"2026-01-05",{"date":665,"type":20},"2026-08-01",{"date":667,"type":20},"2035-07-31",{"name":669,"class":73},"National Taiwan University Hospital"]