[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"knee-osteoarthritis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:knee-osteoarthritis":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,243,0,25,[9,45,73,95,118,142,171,190,214,240,273,297,320,339,356,381,409,429,449,469,491,511,531,564,591],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100054131","effect-of-inspiratory-muscle-training-on-knee-osteoarthritis-pain-100054131",false,"NCT07698418","Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain","Effect of Inspiratory Muscle Training on Pain in Patients With Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 55 years or older.\n* Knee osteoarthritis (Kellgren-Lawrence grade ≥ 2).\n* Knee pain (Visual Analogue Scale, VAS ≥ 3) on the most days in the past month.\n* Able to walk independently without assitive devices.\n\nExclusion Criteria:\n\n* History of knee replacement surgery, meniscus surgery, or ligament surgery.\n* Received corticosteroid injection within the previous three weeks.\n* Diagnosed with rheumatoid arthritis.\n* Unstable angina, recent myocardial infarction, uncontrolled cardiac arrhythmia, or severe heart failure.\n* History of stroke.\n* Currently receiving steroid therapy, hormonal therapy, or cancer chemotherapy.\n* Pneumothorax, pulmonary bullae, lung surgery within the past 12 months, unstable asthma, or severe dyspnea at rest.\n* Unable to understand the study procedures and potential risks.","ALL","55 Years","80 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","Knee osteoarthritis (KOA) is a common joint disease that causes chronic pain and limits daily activities. Current treatments, such as painkillers or surgery, have limitations like side effects or high costs. This study will test whether a safe, non-drug intervention-inspiratory muscle training (breathing exercises against resistance)-can reduce knee pain in people with KOA. The training may work by lowering inflammation and improving the body's nervous system control of pain.\n\nWe plan to enroll 80 patients aged ≥55 years with confirmed KOA and frequent knee pain. Participants will be randomly assigned to either an 8-week inspiratory muscle training program (5 sessions per week, with gradually increasing resistance) or a sham (very low resistance) training program. Neither the patients nor the researchers assessing the outcomes will know who is in which group.\n\nThe main outcome is change in knee pain measured by a visual analog scale (VAS). Secondary outcomes include blood markers of inflammation (TNF-α, IL-6, IL1β), physical function, WOMAC score (a KOA-specific questionnaire), activity level, sleep quality, and quality of life. To explore underlying mechanisms, we will also measure heart rate variability (HRV) as an indicator of autonomic nervous system function, and brain functional connectivity in the prefrontal cortex using functional near-infrared spectroscopy (fNIRS). These mechanistic assessments will be performed at baseline and at the end of 8-week intervention. Additional follow-up assessments for clinical outcomes will be done at 3 and 6 months after the training ends. We will also record any side effects or adverse events.\n\nThis study will provide high-quality evidence on whether inspiratory muscle training is an effective and safe complementary treatment for knee pain in people with knee OA, and will offer new insights into the mechanisms underlying its analgesic effects.",[28,29],"Knee Osteoarthritis","Knee Osteoarthritis (Knee OA)",[28,31,32],"Inspiratory Muscle Training","Chronic Pain","NOT_YET_RECRUITING","2026-07-07",{"date":36,"type":37},"2026-07-13","ACTUAL",{"date":39,"type":22},"2026-07-01",{"date":41,"type":22},"2030-07-01",{"name":43,"class":44},"The Hong Kong Polytechnic University","OTHER",{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":72},"100645047","dose-response-effect-of-intra-articular-ozone-in-knee-osteoarthritis-100645047","NCT07678996","Dose-Response Effect of Intra-Articular Ozone in Knee Osteoarthritis","Dose-Response Effect of Intra-Articular Ozone in Knee Osteoarthritis: A Randomized Controlled Single-Blind Clinical Study","Inclusion Criteria:\n\n* Patients aged 40-75 years diagnosed with knee osteoarthritis according to the American College of Rheumatology 2019 criteria\n* Grade 2 or 3 knee osteoarthritis based on the Kellgren-Lawrence radiological classification system.\n* Presence of chronic knee pain lasting for more than 6 months.\n* Numerical Rating Scale score of 3 or higher during knee-loading activities\n\nExclusion Criteria:\n\n* Presence or history of acute knee infection, major knee trauma, or inflammatory arthritis\n* History of knee fracture or surgical intervention involving the affected knee joint within the last 6 months.\n* History of intra-articular injections (e.g., corticosteroids, hyaluronic acid, PRP) into the affected knee joint within the last 6 months.\n* History of physical therapy or rehabilitation in the knee region within the last 6 months\n* Presence of osteomyelitis adjacent to the knee joint, bacteremia, or hemarthrosis.\n* History of malignancy involving the lower extremity.\n* Known hypersensitivity or allergy to medical ozone.\n* Severe anemia, thrombocytopenia, active bleeding disorders, or ongoing anticoagulant therapy.\n* Pregnancy or lactation\n* Active infection\n* Severe systemic diseases (e.g., advanced cardiopulmonary disease, uncontrolled diabetes mellitus).\n* Hyperthyroidism or progressive neuromuscular disorders.\n* Cognitive impairment or inability to cooperate with the assessment tools and study protocol.","40 Years","75 Years",{"count":21,"type":22},[25],"The goal of this clinical trial is to evaluate the clinical efficacy of different doses of intra-articular ozone injections combined with exercise in patients aged 40-75 diagnosed with Grade 2-3 knee osteoarthritis.\n\nThe main questions it aims to answer are:\n\n* Which intra-articular ozone doses (10 µg\u002FmL, 15 µg\u002FmL, or 20 µg\u002FmL) is most effective in improving pain and physical function in knee osteoarthritis?\n* Do combined ozone and exercise therapies provide superior clinical outcomes compared to exercise therapy alone? Researchers will compare four groups (Ozone 10 µg\u002FmL + Exercise, Ozone 15 µg\u002FmL + Exercise, Ozone 20 µg\u002FmL + Exercise and Exercise Alone) to see the dose-dependent effects of ozone therapy.\n\nParticipants will:\n\n* Complete a structured home exercise program for the duration of the study.\n* Receive 3 sessions of intra-articular ozone injections (for patients allocated to the ozone groups).\n* Participate follow-up visits for clinical and functional assessments at baseline (before the procedure), immediately after the 3rd injection session, at 1 month after the last ozone injection, and at 3 months after the last ozone injection.",[28],[59,60,61],"osteoarthritis","ozone","knee","RECRUITING","2026-06-30",{"date":39,"type":37},{"date":66,"type":37},"2025-11-19",{"date":68,"type":22},"2026-11-30",{"name":70,"class":71},"Kayseri City Hospital","OTHER_GOV",1,{"id":74,"slug":75,"hasResults":12,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":12,"sex":17,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":89,"completionDateStruct":90,"leadSponsor":92,"locationsCount":94},"100644943","acb-and-ipack-blocks-with-intravenous-dexamethasone-and-perineural-dexmedetomidine-in-total-knee-arthroplasty-100644943","NCT07677215","ACB and iPACK Blocks With Intravenous Dexamethasone and Perineural Dexmedetomidine in Total Knee Arthroplasty","Comparison of the Efficacy and Safety of Three Adjuvant Strategies for ACB and iPACK Blocks in Patients Undergoing Elective Total Knee Arthroplasty: A Prospective, Randomized Clinical Trial","Inclusion Criteria:\n\n* Age between 60 and 100 years\n* Scheduled for elective primary unilateral total knee arthroplasty\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Ability to understand study procedures and provide written informed consent\n* Eligibility for spinal anesthesia and ultrasound-guided regional anesthesia according to institutional standards\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to ropivacaine, dexamethasone, dexmedetomidine, or any study-related medication\n* Contraindications to spinal anesthesia or peripheral nerve blocks\n* Coagulation disorders or anticoagulant therapy preventing safe regional anesthesia\n* Infection at the planned puncture site or systemic infection\n* Severe neurological disorders affecting lower limb sensory or motor function\n* Severe hepatic, renal, or uncontrolled cardiovascular disease\n* Clinically significant bradycardia or advanced atrioventricular conduction abnormalities\n* Chronic opioid use for more than 3 months before surgery\n* Uncontrolled diabetes mellitus or contraindications to dexamethasone administration\n* Inability or refusal to provide written informed consent","60 Years","100 Years",{"count":83,"type":22},120,[25],"This prospective randomized controlled trial aims to compare the analgesic efficacy and safety of three adjuvant strategies for ultrasound-guided Adductor Canal Block (ACB) and iPACK block in patients undergoing elective total knee arthroplasty under spinal anesthesia. All participants will receive standardized spinal anesthesia with 0.5% ropivacaine combined with ACB and iPACK blocks using 0.2% ropivacaine. Patients will be randomized into one of three groups: standard ACB + iPACK without adjuvants, ACB + iPACK with intravenous dexamethasone 8 mg, or ACB + iPACK with intravenous dexamethasone 8 mg combined with perineural dexmedetomidine added to both regional blocks.\n\nThe primary outcome will be total postoperative opioid consumption during the first 48 hours after surgery expressed as intravenous morphine equivalents. Secondary outcomes will include pain intensity at rest and during movement, duration of analgesia, time to first rescue analgesia, quadriceps muscle strength, early mobilization, adverse events, inflammatory markers, and length of hospital stay.",[28],"2026-06-29",{"date":63,"type":37},{"date":39,"type":22},{"date":91,"type":22},"2027-10-01",{"name":93,"class":44},"Poznan University of Medical Sciences",2,{"id":96,"slug":97,"hasResults":12,"nctId":98,"briefTitle":99,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":12,"sex":17,"minAge":101,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":23,"phases":104,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":114,"leadSponsor":116,"locationsCount":72},"100643880","intraarticular-injection-of-botox-and-hyaluronic-acid-in-knee-osteoarthritis-100643880","NCT07666347","Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis","Inclusion Criteria:\n\n* Age ≥ 50 years.\n* Both genders.\n* Chronic knee osteoarthritis (KOA) according to American College of Rheumatology criteria for the diagnosis of knee osteoarthritis.\n* Third or fourth grade Kellgren and Lawrence system for classification of osteoarthritis based on radiological data, it is a common method of classifying the severity of osteoarthritis (OA) using five grades according to the following sites and projections.\n\nExclusion Criteria:\n\n* History of intra-articular injection within the last 6 months,\n* History of surgery on the knee joint or major trauma to the lower limb causing fracture.\n* Body mass index (BMI) more than 40 kg\u002Fm2.\n* Medical conditions affecting the joint or lower extremity function such as severe osteoporosis, rheumatoid arthritis, collagen vascular diseases, and gout.\n* Diabetic patient.\n* Any contraindication to intra-articular injections for instance immunodeficiency, coagulation defect or anticoagulation therapy taking or skin infection at the site of injection.\n* Hypersensitivity to Botulinum toxin or hyaluronic acid.","50 Years",{"count":103,"type":22},50,[25],"This study aims to compare the efficacy of intra-articular injection of Botulinum toxin and hyaluronic acid on pain in knee osteoarthritis.",[107,108,109,28],"Intraarticular Injection","Botox","Hyaluronic Acid","2026-06-24",{"date":112,"type":37},"2026-06-25",{"date":110,"type":37},{"date":115,"type":22},"2026-12-01",{"name":117,"class":44},"Tanta University",{"id":119,"slug":120,"hasResults":12,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":12,"sex":17,"minAge":126,"maxAge":4,"enrollmentInfo":127,"targetDuration":4,"studyType":23,"phases":129,"briefSummary":130,"conditions":131,"keywords":132,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":94},"100602585","shock-wave-treatment-in-patients-with-knee-osteoarthritis-100602585","NCT07125430","Shock Wave Treatment in Patients With Knee Osteoarthritis","Efficacy of Shock Wave Treatment to Reduce Pain and Improve Functionality in Patients With Knee Osteoarthritis: Randomized Clinical Trial.","SWKO","Inclusion Criteria:\n\n* Knee pain assessed according to the VAS scale, with a score equal to or greater than 4 in the last 3 months.\n* Osteoarthritis grade 2 or 3 in the Kellgren-Lawrence classification.\n* Informed consent signature\n\nExclusion Criteria:\n\n* Stroke in the last 3 months, knee surgery in the last 3 months, intra-articular infiltration in the last 3 months, secondary knee osteoarthritis, chronic inflammatory disease","18 Years",{"count":128,"type":22},40,[25],"Introduction: Knee osteoarthritis represents a significant health problem due to its impact on the functionality and quality of life of patients. Its treatment can be pharmacological, non-pharmacological, or surgical. Recently, the chondroprotective potential of shockwave therapy has been evidenced.\n\nObjective: To determine whether shockwave treatment combined with knee strengthening exercises is superior to knee strengthening exercises alone in reducing pain and improving function in patients with knee osteoarthritis.\n\nMethod: A randomized controlled trial with allocation concealment is proposed. Patients with knee pain secondary to knee osteoarthritis will participate during their hospital admission. Two groups will be formed: both will follow an exercise program for three weeks, and the intervention group will add a weekly shockwave session during that same period.\n\nThe main variable will be pain intensity; other variables include stiffness, functional capacity, degree of satisfaction, and data related to the application of therapy (frequency, intensity, number of pulses, side effects). Clinical data will also be collected such as reason for admission, age, sex, comorbidities, degree of dependency, walking ability, analgesia, use of assistive devices, and progress during treatment.\n\nApplicability: The results could lead to a change in clinical practice, serving as a basis for modifying treatment protocols for knee osteoarthritis in medium-stay hospitals. Furthermore, they would provide additional scientific evidence on the efficacy of shock wave therapy for this condition.",[28],[133],"shock waves, knee osteoarthritis, rehabilitation",{"date":135,"type":37},"2026-06-26",{"date":137,"type":22},"2026-07-30",{"date":139,"type":22},"2027-12-30",{"name":141,"class":44},"Guadarrama Hospital",{"id":143,"slug":144,"hasResults":12,"nctId":145,"briefTitle":146,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":12,"sex":17,"minAge":148,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":23,"phases":152,"briefSummary":153,"conditions":154,"keywords":161,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":164,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":72},"100504462","gait-rehabilitation-to-treat-fastoa-100504462","NCT05848622","Gait Rehabilitation to Treat FastOA","Inclusion Criteria:\n\n* Have completed all other formal physical therapy\n* Are between the ages of 16 and 35\n* Underwent an anterior cruciate ligament reconstruction (ACLR) between 6 and 60 months prior to enrollment\n* Demonstrate underloading during gait (vGRF- impact peak \\\u003C1.12 x BW)\n\nExclusion Criteria:\n\n* A multiple ligament surgery (i.e., PCL)\n* A lower extremity fracture (i.e., displaced tibial plateau fracture)\n* Knee osteoarthritis","16 Years","35 Years",{"count":151,"type":22},70,[25],"The purpose of this study is to determine the effects of real-time gait biofeedback delivered over a 6-week period on early markers of FastOA and conduct 6-week and 6-month follow-up assessments in anterior cruciate ligament reconstructed patients.",[155,156,28,157,158,159,160],"Anterior Cruciate Ligament Injuries","Post-traumatic Osteoarthritis","Osteo Arthritis Knee","Knee Injuries","Cartilage, Articular","Gait",[162,163],"Biofeedback","FastOA",{"date":112,"type":37},{"date":166,"type":37},"2023-06-13",{"date":168,"type":22},"2027-06",{"name":170,"class":44},"University of North Carolina, Chapel Hill",{"id":172,"slug":173,"hasResults":12,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":12,"sex":17,"minAge":126,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":23,"phases":180,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":72},"100644127","cryoneurolysis-versus-radiofrequency-in-knee-osteoarthritis-100644127","NCT07664371","Cryoneurolysis Versus Radiofrequency in Knee Osteoarthritis","Cryoneurolysis Versus Radiofrequency in Knee Osteoarthritis: A Randomised Controlled Trial","Inclusion Criteria:\n\n1. adults between the ages of 30 and 70 years with a clinical diagnosis of refractory knee OA who suffered from knee pain.\n2. Patients who cannot afford intra-articular injections.\n3. patients who had failed 2 different oral pain medications, and 6 weeks of physical therapy.\n\nExclusion Criteria:\n\n1. Patients with OA show improvement in pain after physiotherapy.\n2. patients evaluated by an orthopedic surgeon and deemed to be surgical candidates due to knee pathologies other than OA.\n3. pregnant patients.\n4. patients on anticoagulation therapy, who were not permitted to stop anticoagulation.\n5. patients with previous trauma, neurological or endocrine diseases like diabetes mellitus, and knee tumors; and patients with inflammatory arthritis.\n6. people who had received an intra-articular knee injection within the last 6 months.\n7. Patients with tendon tears, bursitis, or calcified tendonitis as proven by imaging.",{"count":179,"type":22},60,[25],"The project will evaluate the effectiveness of Cryoneurolysis versus radiofrequency procedures in adult patients who are resistant to traditional treatment for knee pain. They are a drug-free pain management procedure.",[28],"2026-06-23",{"date":135,"type":37},{"date":186,"type":37},"2026-06-10",{"date":188,"type":22},"2026-11",{"name":117,"class":44},{"id":191,"slug":192,"hasResults":12,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":12,"sex":17,"minAge":126,"maxAge":4,"enrollmentInfo":197,"targetDuration":4,"studyType":23,"phases":199,"briefSummary":200,"conditions":201,"keywords":202,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":206,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":94},"100564322","multicenter-ide-study-of-the-peek-optima-femoral-component-vs-a-cocr-alloy-tka-femoral-component-of-similar-design-100564322","NCT06627673","MultiCenter IDE Study of the PEEK-OPTIMA™ Femoral Component vs a CoCr Alloy TKA Femoral Component of Similar Design","MultiCenter Prospective Parallel Registry Controlled Investigational Device Exemption Clinical Study to Determine Non-Inferiority of the PEEK-OPTIMA™ Femoral Component Versus a CoCr Alloy Femoral Component of Similar Design for TKA","Inclusion Criteria:\n\n* Male and female subjects 18 years of age or older.\n* Subjects with a primary diagnosis of end-stage symptomatic unilateral primary knee osteoarthritis.\n* Subjects with a pre-operative Knee Society Score (KSS) Knee score of \\>25 and \\\u003C75.\n* Subjects who, in the opinion of the Investigator, can understand this clinical investigation, co-operate with the investigational procedures and are willing to return to the hospital for all the required post-operative follow-ups.\n* Subjects who can give voluntary, written informed consent to participate in this clinical investigation and from whom consent has been obtained.\n\nExclusion Criteria:\n\n* Subjects who, in the opinion of the Investigator, have an existing condition that would compromise their participation and follow-up in this clinical investigation.\n* Subjects who are known drug or alcohol abusers or with psychological disorders that could affect follow-up care or treatment outcomes.\n* Subjects who have participated in a clinical study with an investigational product in the last 6 months.\n* Subjects with other significant disabling problems from the muscular-skeletal system other than in the knees (i.e.: muscular dystrophy, polio, neuropathic joints).\n* Subjects with known osteoporosis and\u002For previous history of fracture related to osteoporosis.\n* Subjects with a current or active history of malignancy, active or suspected infection, Paget's disease, renal osteodystrophy, immunologically suppressed, rheumatoid arthritis, sickle cell anemia, and systemic lupus erythematosus.\n* Subjects defined by the Investigator as American Society of Anesthesiologists (ASA) Grade III or IV.\n* Subjects who have a neuromuscular or neurosensory deficit.\n* Female subjects who are pregnant or lactating.\n* Subjects with an anatomical limb alignment of above 20 degrees varus or valgus.\n* Subjects with primary or secondary diagnosis of inflammatory or traumatic arthritis.\n* Subjects with a fixed flexion deformity of over 20 degrees.\n* Subjects with recurvatum (definition: hyperextension ≥ 5 degrees).\n* Subjects who have previously undergone surgery on the indicated knee including total knee arthroplasty, patellofemoral arthroplasty, or unicondylar knee arthroplasty, high tibial osteotomy, ligament reconstruction, fusion, open reduction and internal fixation.\n* Subjects that have undergone, or scheduled to undergo, contralateral total knee arthroplasty or unicondylar knee arthroplasty within ±1 year from the study surgical procedure.\n* Evidence of active or suspected (systemic or local) infection at time of surgery.",{"count":198,"type":22},200,[25],"The purpose of this investigational device exemption (IDE) study is to monitor the performance (safety and efficacy) of the Maxx Orthopedics, Freedom Total Knee® System, with a femoral component of similar design, manufactured from polyether-ether-ketone (PEEK).",[28],[203,204,205],"Total Knee Replacement","Total Knee Arthroplasty","Polyether-ether-ketone",{"date":135,"type":37},{"date":208,"type":37},"2026-01-01",{"date":210,"type":22},"2029-03-01",{"name":212,"class":213},"Maxx Orthopedics Inc","INDUSTRY",{"id":215,"slug":216,"hasResults":12,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":12,"sex":17,"minAge":126,"maxAge":222,"enrollmentInfo":223,"targetDuration":4,"studyType":23,"phases":225,"briefSummary":226,"conditions":227,"keywords":228,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":235,"completionDateStruct":236,"leadSponsor":238,"locationsCount":72},"100644003","health-aid-for-knee-osteoarthritis-100644003","NCT07669532","Health Aid for Knee Osteoarthritis","A Randomized Controlled Trial of a Health Aids for Knee Osteoarthritis","KOA-HAID","Inclusion Criteria:\n\n* New patient seeking musculoskeletal specialty care\n* English literacy\n* Aged 18-89 years\n* Diagnosed with knee osteoarthritis\n\nExclusion Criteria:\n\n* Cognitive or physical impairment precluding tablet use","89 Years",{"count":224,"type":22},159,[25],"Knee osteoarthritis is a common condition that can cause pain, stiffness, and difficulty with daily activities. Many patients interpret these symptoms as signs of ongoing joint damage, which can influence their expectations and decisions about treatment.\n\nThis randomized controlled trial compares three approaches used during a routine orthopedic visit: a health aid, a decision aid, and usual care. The health aid is designed to improve patients' understanding of knee osteoarthritis by addressing common misconceptions and helping patients develop a more accurate and less distressing understanding of their condition. The decision aid provides structured information about treatment options. In the usual care group, patients receive standard clinical consultation without additional educational materials.\n\nThe main goal of the study is to evaluate differences in patients' understanding of knee osteoarthritis immediately after the clinic visit. Secondary outcomes include patients' interest in additional care options such as imaging, physical therapy, injections, and surgery, as well as measures of trust in the clinician and care experience.\n\nThe results of this study may help improve how information is communicated to patients with knee osteoarthritis and guide future approaches to patient education and shared decision-making.",[28],[229,230,231,232],"Knee osteoarthritis","Health aid","Patient education","Decision aid","2026-06-21",{"date":112,"type":37},{"date":39,"type":22},{"date":237,"type":22},"2026-12-31",{"name":239,"class":44},"David Ring",{"id":241,"slug":242,"hasResults":12,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":246,"eligibilityCriteria":247,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":80,"enrollmentInfo":248,"targetDuration":4,"studyType":249,"phases":4,"briefSummary":250,"conditions":251,"keywords":253,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":72},"100638384","blood-cell-ratios-as-predictors-of-response-to-platelet-rich-plasma-in-knee-osteoarthritis-100638384","NCT07617233","Blood Cell Ratios as Predictors of Response to Platelet-Rich Plasma in Knee Osteoarthritis","Baseline Neutrophil-to-Lymphocyte Ratio and Related Complete Blood Count-Derived Inflammatory Indices as Predictors of Clinical Response to Intra-Articular Platelet-Rich Plasma in Knee Osteoarthritis: A Prospective Single-Arm Cohort Study","PRP-NLR","Inclusion Criteria:\n\n* Age 40 to 60 years\n* Symptomatic primary knee osteoarthritis, Kellgren-Lawrence grade 2 or 3 on weight-bearing radiographs\n* Body mass index below 40\n* Candidate for and scheduled to receive a course of intra-articular platelet-rich plasma for the index knee\n* Able and willing to provide written informed consent and to attend the 6-month follow-up schedule\n\nExclusion Criteria:\n\n* Systemic inflammatory or autoimmune disease\n* Active acute infection at the time of enrollment\n* Current anticoagulant or antiplatelet therapy, or current or recent chemotherapy\n* Any contraindication to platelet-rich plasma per the 2025 GRIIP recommendations\n* Intra-articular injection of the index knee within the previous 6 months\n* Inability to comply with the planned follow-up schedule",{"count":83,"type":22},"OBSERVATIONAL","Intra-articular platelet-rich plasma (PRP) injection is a widely used treatment for knee osteoarthritis, but patients respond to it very differently and there is currently no simple, inexpensive way to predict who will benefit. The neutrophil-to-lymphocyte ratio (NLR) and related indices derived from a routine complete blood count reflect a person's baseline inflammatory state. This prospective single-arm observational cohort study investigates whether the baseline NLR, together with the platelet-to-lymphocyte ratio (PLR), the systemic immune-inflammation index (SII), and the monocyte-to-lymphocyte ratio (MLR), predicts the clinical response to intra-articular PRP in patients with Kellgren-Lawrence grade 2 to 3 knee osteoarthritis. The investigators will enroll 120 patients aged 40 to 60 years, each of whom receives a standardized course of three leukocyte-poor PRP injections one week apart. Patients are followed for 6 months, and the primary clinical outcome is the change in the WOMAC osteoarthritis index at 6 months. Outcome assessors are blinded to patients' blood-count values. If a baseline blood ratio predicts response, it could become a low-cost tool to guide patient selection for PRP.",[28,252],"Osteoarthritis",[254,255,256,257,258,259,260,261,262,263,264],"platelet-rich plasma","PRP","knee osteoarthritis","neutrophil-to-lymphocyte ratio","NLR","systemic immune-inflammation index","biomarker","predictor","intra-articular injection","WOMAC","inflammatory index","2026-06-18",{"date":183,"type":37},{"date":268,"type":22},"2026-09",{"date":270,"type":22},"2027-07",{"name":272,"class":44},"Utku Gürhan",{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":279,"eligibilityCriteria":280,"healthyVolunteers":12,"sex":17,"minAge":281,"maxAge":4,"enrollmentInfo":282,"targetDuration":4,"studyType":23,"phases":284,"briefSummary":285,"conditions":286,"keywords":287,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":293,"leadSponsor":295,"locationsCount":4},"100609159","self-managed-vs-supervised-exercise-for-knee-oa-100609159","NCT07210931","Self-managed vs Supervised Exercise for Knee OA","A Cluster Randomized Trial in Patients With Knee Osteoarthritis Comparing Self-Managed Exercise in Fitness Centers With Physiotherapist-Supervised Exercise in Primary Care","SELFIT","Inclusion criteria\n\n• Diagnosis of knee OA according to the NICE criteria: Adults aged 45 or over with activity-related joint pain and either no morning joint-related stiffness or morning stiffness that lasts no longer than 30 minutes.\n\nExclusion criteria\n\n* Completion of a supervised therapeutic exercise program for knee OA within 3 months\n* Contraindication to exercise (e.g., resting systolic blood pressure \\> 200 or diastolic blood pressure \\>110 mmHg, acute or reoccurring chest pain, unstable angina. uncontrolled cardiac arrhythmias, decompensated heart failure. suspected or known dissecting aortic aneurysm)\n* Lack of independent mobility that requires aid for transportation to\u002Ffrom exercise facilities.\n* Any condition or impairment that, in the opinion of the recruiting GP, makes a potential participant unsuitable for participation or which may obstruct participation (e.g. psychiatric or cognitive disorders, language barriers, or opiate dependency).","45 Years",{"count":283,"type":22},300,[25],"Knee osteoarthritis (OA) is a common painful condition associated with pain and disability. OA healthcare costs the Danish society 4.6 billion DKK more per year than the non-OA population and we lack evidence on how best to organize and deliver care to reduce costs. Recommended first line treatment for knee OA is exercise with proven effects on symptoms. The current paradigm assumes that exercise needs to be delivered and supervised by a physiotherapist which require patients to attend a clinic at specific times and geographical locations. This is an expensive model of care and creates barriers for people that are active on the labor market or lives in remote areas with long distances to the nearest clinic. In fact, the productivity loss in Denmark associated with OA is estimated to be 12.4 billion DKK per year.\n\nWhile effective on symptoms, the current model with supervised physiotherapy associates with significant shortcomings, and barriers related to patient heterogeneity, costs, accessibility, and work absenteeism.\n\nAs an alternative, a local fitness center is far more accessible as these are widely dispersed across the country, are accessible daily (including weekends) at all hours, is cheap and offers a wide variety of exercise types, classes, and equipment to accommodate individual preferences. The cost of a fitness center membership is approximately 300 DKK per month and includes exercise ad libitum. In contrast, a typical physiotherapist-supervised exercise program costs 3-4,000 DKK for a 2-month treatment with 2 weekly sessions.\n\nConsequently, there is a need to investigate if self-managed exercise in a fitness center is cost-effective as first-line management of knee OA. To answer this question, the present trial aims to compare self-managed exercise in a fitness center to the current standard - supervised exercise. This has the potential to improve quality of care for people with knee OA by adding a cost-effective option for first line management of people with knee OA.",[28],[288],"Exercise","2026-06-15",{"date":291,"type":37},"2026-06-16",{"date":39,"type":22},{"date":294,"type":22},"2027-12-31",{"name":296,"class":44},"Marius Henriksen",{"id":298,"slug":299,"hasResults":12,"nctId":300,"briefTitle":301,"officialTitle":301,"acronym":302,"eligibilityCriteria":303,"healthyVolunteers":12,"sex":17,"minAge":126,"maxAge":4,"enrollmentInfo":304,"targetDuration":4,"studyType":249,"phases":4,"briefSummary":306,"conditions":307,"keywords":309,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":72},"100442290","efficacy-at-one-year-of-combined-injections-of-plasma-rich-in-platelets-and-hyaluronic-acid-in-knee-osteoarthritis-100442290","NCT05039463","Efficacy at One Year of Combined Injections of Plasma Rich in Platelets and Hyaluronic Acid in Knee Osteoarthritis","ISPAG","Inclusion Criteria:\n\n* age : \\> 18 years old\n* Patients benefiting, in the context of knee osteoarthritis, from viscosupplementation alone or from two injections of PRP, in combination with HA, at the Amiens University Hospital.\n\nExclusion Criteria:\n\n* Patient refusal to use the data\n* Language barrier\n* Age less than 18 years old.",{"count":305,"type":22},100,"The French Society of Rheumatology cannot rule on the value of intra-articular injections of PRP due to the lack of hindsight and insufficient data. In fact, the injection protocols are very heterogeneous in terms of preparation method, the presence or not of leukocytes, the number of centrifugations, the volume injected, the ultrasound guidance, which makes it difficult to analyze the literature. The investigator objective is therefore to evaluate the effectiveness of combined injections of PRP and hyaluronic acid.",[28,109,308],"Platelet Rich Plasma",[310,311,28],"platelet rich plasma","hyaluronic acid","2026-06-12",{"date":289,"type":37},{"date":315,"type":37},"2021-08-16",{"date":317,"type":22},"2026-06",{"name":319,"class":44},"Centre Hospitalier Universitaire, Amiens",{"id":321,"slug":322,"hasResults":12,"nctId":323,"briefTitle":324,"officialTitle":324,"acronym":4,"eligibilityCriteria":325,"healthyVolunteers":12,"sex":17,"minAge":149,"maxAge":326,"enrollmentInfo":327,"targetDuration":4,"studyType":23,"phases":329,"briefSummary":330,"conditions":331,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":332,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":94},"100398788","fluoroscopic-versus-ultrasound-guidance-for-cooled-radiofrequency-ablation-of-geniculate-nerves-in-knee-osteoarthritis-a-randomized-control-trial-100398788","NCT04472702","Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial","Inclusion Criteria:\n\n* 1\\) patients of either gender with primary knee OA of one or both knees fulfilling the diagnostic criteria for knee OA by the American College of Rheumatology,\n* 2\\) Kellgren-Lawrence score of two to four,\n* 3\\) reported NPRS pain intensity of at least four on most or all days of the past week\n* 4\\) pain resistant to conventional treatments which may include but is not limited to medications (e.g. acetaminophen, oral or topical non-steroidal anti-inflammatory drugs, opioids), physical therapy, and intra-articular injections (e.g. corticosteroids, hyaluronic acid, platelet-rich-plasma) for at least 3 months. In the case of bilateral knee OA, the most symptomatic knee will be treated and studied.\n\nExclusion Criteria:\n\n* 1\\) age \\\u003C35 years,\n* 2\\) non-English speaking patients,\n* 3\\) body mass index greater than 40,\n* 4\\) previous radiofrequency ablation procedure for the knee,\n* 5\\) active systemic or local infections at the site of needle\u002FcRFA probe placement,\n* 6\\) previous knee joint replacement surgery,\n* 7\\) autoimmune or inflammatory cause of knee arthritis such as rheumatoid or psoriatic arthritis,\n* 8\\) non-ambulatory patients,\n* 9\\) patients who are unable to provide their own consent (e.g. dementia),\n* 10\\) unstable medical or psychiatric illness,\n* 11\\) patients with pacemakers, spinal cord stimulators, deep brain stimulators, or similar devices,\n* 12\\) patients seeking care as a part of workman's compensation or have litigation pending\n* 13\\) a negative response to diagnostic geniculate nerve lidocaine injections.","99 Years",{"count":328,"type":22},90,[25],"Cooled radiofrequency ablation (cRFA) of the knee geniculate nerves is a promising treatment option for knee osteoarthritis, but has variable efficacy. Fluoroscopy is the typical guidance of choice, but uses bony landmarks to target these nerves which have variable positions around the knee. Alternatively, ultrasound allows for targeting based on visualization of bony landmarks, the nerves, and their accompanying vascular structures, and thus may offer greater accuracy. However, there are few studies which directly compare the clinical efficacy of these two guidance options. This study will compare these two options.",[28],{"date":291,"type":37},{"date":334,"type":37},"2022-02-02",{"date":336,"type":22},"2027-05-01",{"name":338,"class":44},"University of California, Davis",{"id":340,"slug":341,"hasResults":12,"nctId":342,"briefTitle":343,"officialTitle":343,"acronym":344,"eligibilityCriteria":345,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":346,"targetDuration":4,"studyType":249,"phases":4,"briefSummary":347,"conditions":348,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":351,"completionDateStruct":352,"leadSponsor":354,"locationsCount":4},"100642756","effect-of-alexithymia-on-response-to-physical-therapy-in-patients-with-knee-osteoarthritis-100642756","NCT07651410","Effect of Alexithymia on Response to Physical Therapy in Patients With Knee Osteoarthritis","ALEX-KOA","Inclusion Criteria:\n\nAge between 40 and 75 years. Diagnosis of knee osteoarthritis according to the American College of Rheumatology (ACR) criteria.\n\nKellgren-Lawrence grade II or III on radiographic evaluation. Presence of symptomatic knee pain requiring physical therapy. Willingness and ability to participate in the standardized physical therapy program.\n\nAbility to complete study questionnaires and clinical assessments. Provision of written informed consent prior to participation.\n\nExclusion Criteria:\n\nAge younger than 40 years or older than 75 years. Kellgren-Lawrence grade I or grade IV knee osteoarthritis. Previous knee arthroplasty or major knee surgery on the affected side. Lower extremity surgery within the previous 6 months. Intra-articular corticosteroid, hyaluronic acid, platelet-rich plasma, prolotherapy, or stem cell injection into the knee within the previous 3 months.\n\nPhysical therapy for knee osteoarthritis within the previous 3 months. Acute knee trauma or fracture. Inflammatory rheumatic diseases (e.g., rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis).\n\nFibromyalgia or chronic widespread pain syndrome. Active infection or malignancy. Neurological disorders significantly affecting lower extremity function or balance (e.g., stroke, Parkinson's disease, multiple sclerosis).\n\nSevere cognitive impairment or major psychiatric illness that may interfere with study participation or questionnaire completion.\n\nContraindications to physical therapy modalities (TENS, therapeutic ultrasound, or superficial heat therapy).\n\nRegular opioid analgesic use or other medications that may substantially influence pain perception.\n\nPregnancy or breastfeeding. Inability to comply with the treatment protocol or follow-up assessments. Participation in another interventional clinical study during the study period. Refusal or inability to provide written informed consent.\n\n\\-",{"count":179,"type":22},"Knee osteoarthritis is one of the most common degenerative joint diseases and is associated with chronic pain, functional impairment, and reduced quality of life. Psychological factors may influence both symptom severity and response to treatment. Alexithymia, characterized by difficulty in identifying and expressing emotions, has been associated with poorer outcomes in chronic pain conditions.\n\nThe aim of this prospective observational study is to investigate whether the presence of alexithymia affects the clinical response to a standardized physical therapy program in patients with knee osteoarthritis. Participants will undergo a standard physical therapy regimen and will be evaluated before treatment, immediately after treatment, and 6 weeks after treatment completion. Pain, functional status, alexithymia, anxiety, and depression will be assessed using validated clinical scales. The study seeks to determine whether alexithymia is an independent predictor of treatment response in patients with knee osteoarthritis.",[28],"2026-06-11",{"date":291,"type":37},{"date":112,"type":22},{"date":353,"type":22},"2026-11-01",{"name":355,"class":44},"Kanuni Sultan Suleyman Training and Research Hospital",{"id":357,"slug":358,"hasResults":12,"nctId":359,"briefTitle":360,"officialTitle":361,"acronym":362,"eligibilityCriteria":363,"healthyVolunteers":12,"sex":17,"minAge":126,"maxAge":4,"enrollmentInfo":364,"targetDuration":4,"studyType":23,"phases":366,"briefSummary":367,"conditions":368,"keywords":369,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":374,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":72},"100594225","efficacy-of-therapy-with-prp-injections-versus-ha-in-patients-with-advanced-grade-of-gonarthrosis-100594225","NCT07016672","Efficacy of Therapy With PRP Injections Versus HA in Patients With Advanced Grade of GONArthrosis","Efficacy of Therapy With Intra-articular Injections of PRP Compared With Therapy With Intra-articular Injections of HA, in Patients With Grade III or IV GONArthrosis: a Prospective Randomized Open-label Study","PAGONA","Inclusion Criteria:\n\n1. Age ≥ 18 years ;\n2. MRI confirmed grade III or IV unilateral gonarthrosis ;\n3. Pain ≥ 3\u002F10 on the visual analogue scale (VAS);\n4. Patient with a BMI \\\u003C 35\n5. Patient capable of giving consent prior to participation in the study;\n6. Affiliated or entitled under a social security scheme.\n\nExclusion Criteria:\n\n1. Non-steroidal anti-inflammatory drugs\\* or corticosteroids\\*\\* taken in the 7 days prior to inclusion;\n2. Local injection of hyaluronic acid in the 2 months prior to inclusion;\n3. Local injection of PRP within 1 year prior to inclusion;\n4. Local injection of corticosteroids within 5 months prior to inclusion;\n5. Current anticoagulant treatment that cannot be stopped during the hyaluronic acid or PRP injection protocol period;\n6. Patient diagnosed with any type of cancer in the last 3 years;\n7. Pregnant women, women in labour or breast-feeding women;\n8. Patients under judicial protection (guardianship, curatorship, etc.) or safeguard of justice;\n9. Any other reason which, in the opinion of the investigator, could interfere with the evaluation of the study objectives.\n\n   * Acetylsalicylic acid is allowed when it is prescribed as an antiplatelet agent at doses lower than or equal to 160 mg per day. It has, indeed, no anti-inflammatory effect at these doses.\n\n     * Corticosteroids can be administered when they have a local action different from the one applied to the treated knee (cutaneous, instiled or inhaled routes).",{"count":365,"type":22},150,[25],"Gonarthrosis is a chronic pathology affecting the knee joint and tissues. It is characterized by progressive degeneration of articular cartilage, bone and surrounding structures. Diagnosis is based on clinical, biological and radiological criteria.\n\nWhen knee osteoarthritis becomes symptomatic, it leads to pain associated with stiffness and functional discomfort, impacting on patients' quality of life. Patients become sedentary and isolated, which has cardiovascular and psychological consequences, with a proven excess mortality rate.\n\nTo date, there are no curative treatments for gonarthrosis. Available treatments are generally aimed at relieving pain, improving joint function and slowing disease progression. Therapeutic approaches most often combine non-pharmacological treatments such as dietary measures, regular physical activity and therapeutic education, with pharmacological treatments: paracetamol, non-steroidal anti-inflammatory drugs, opioids, intra-articular injections of corticosteroids, hyaluronic acid (HA), Platelet Rich Plasma (PRP)... If these are ineffective, particularly in advanced stages (grades III-IV), then surgery for prosthesis is necessary. However, surgery is not an option for all patients, particularly those with co-morbidities, the elderly or those who refuse it.\n\nThe osteoarthritis section of the French rheumatology society has drawn up recommendations, with a view to positioning these treatments, standardizing practices and improving the management of gonarthrosis patients in France. These point out that further studies are needed to validate the efficacy of certain treatments, notably intra-articular PRP injections, which are nevertheless widely used in current practice and defended by a consensus of French experts published in 2021. Indeed, the results of several therapeutic trials and meta-analyses already published show that its efficacy is often superior to that of HA, particularly in terms of symptom improvement and over a longer duration. In order to make the case for their use to learned societies, literature data must be enriched, particularly with regard to advanced stages of gonarthrosis, i.e. stages III-IV, which are the most painful. The aim is to propose an effective treatment to relieve the symptoms of patients for whom surgery is not an option.",[28],[370,371,308,311,372,373],"Pain","Functional impact","Intra-articular injection","Advanced grade",{"date":312,"type":37},{"date":376,"type":37},"2025-09-18",{"date":378,"type":22},"2028-10",{"name":380,"class":44},"Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer",{"id":382,"slug":383,"hasResults":12,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":387,"eligibilityCriteria":388,"healthyVolunteers":389,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":390,"targetDuration":4,"studyType":23,"phases":392,"briefSummary":394,"conditions":395,"keywords":397,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":401,"startDateStruct":402,"completionDateStruct":404,"leadSponsor":406,"locationsCount":72},"100642469","phase-2-duloxetine-and-aerobic-exercise-to-improve-function-in-veterans-with-knee-osteoarthritis-drive-100642469","NCT07649291","Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)","Duloxetine Plus Exercise to Improve Physical Function in Veterans With Knee Osteoarthritis, Pain, and Psychological Comorbidity","DRIVE","Inclusion Criteria:\n\n* Veterans aged ≥40 years\n* English-speaking\n* symptomatic KOA based on American College of Rheumatology (ACR) criteria\n* Patient Health Questionnaire-9 (PHQ-9) scores indicating mild to severe depressive symptoms\n* no planned knee surgery within the next 6 months\n* ability to participate in supervised aerobic exercise\n\nExclusion Criteria:\n\n* current use of antidepressants, opioids, benzodiazepines, or antipsychotics\n* engaging in structured aerobic or resistance exercise ≥3 times per week\n* cognitive impairment defined as a Mini-Mental State Examination (MMSE) score \\\u003C20\n* diagnosis of bipolar disorder, psychosis, recent substance use disorder, or suicidal ideation per the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)\n* medical conditions contraindicating exercise (e.g., recent myocardial infarction, unstable angina, peripheral arterial disease with ulcers, -uncontrolled hypertension \\>190\u002F110, or New York Heart Association class ≥3 cardiac or pulmonary disease)\n* pregnant or lactating individuals\n* active cancer that is currently undergoing treatment (receiving chemotherapy and\u002For radiation therapy\n* other conditions deemed by study team to endanger the health of the participant",true,{"count":391,"type":22},102,[393],"PHASE2","Knee osteoarthritis (KOA) is one of the most common causes of chronic pain, mobility problems, and disability among United States Veterans. Many Veterans with KOA also experience depressive symptoms, which can worsen pain, reduce motivation to exercise, and make recovery more difficult. This study will test whether a structured hybrid aerobic exercise program that combines supervised and home-based walking with the medication duloxetine can improve physical function, reduce pain, lessen depressive symptoms, and improve overall health-related outcomes in Veterans with KOA. The goal of this research is to develop a practical and scalable treatment strategy that could improve rehabilitation and quality of life for Veterans with chronic knee pain and depressive symptoms and potentially be adapted for other chronic musculoskeletal conditions treated within the VA healthcare system.",[28,370,396],"Depression",[288,370,398,399,400],"Depressive symptoms","Physical Function","Duloxetine",{"date":291,"type":37},{"date":403,"type":22},"2027-03-01",{"date":405,"type":22},"2032-09-01",{"name":407,"class":408},"VA Office of Research and Development","FED",{"id":410,"slug":411,"hasResults":12,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":4,"eligibilityCriteria":415,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":416,"targetDuration":4,"studyType":23,"phases":418,"briefSummary":419,"conditions":420,"keywords":421,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":423,"startDateStruct":424,"completionDateStruct":425,"leadSponsor":427,"locationsCount":4},"100643032","clinical-trial-to-evaluate-the-efficacy-and-safety-of-conjuran-after-first-and-second-cycle-repeat-administration-in-patients-with-knee-osteoarthritis-100643032","NCT07646483","Clinical Trial to Evaluate the Efficacy and Safety of Conjuran® After First and Second Cycle (Repeat) Administration in Patients With Knee Osteoarthritis","A Multicenter, Randomized, Double-Blind, Active-Controlled, Non-Inferiority Clinical Trial to Evaluate the Efficacy and Safety of Intra-Articular Conjuran® After First and Second Cycle (Repeat) Administration in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Age ≥40 years\n* Knee osteoarthritis diagnosed according to ACR criteria\n* KL grade I-III\n* Weight-bearing pain VAS ≥40 mm\n* Written informed consent\n\nExclusion Criteria:\n\n* Inflammatory or secondary arthritis\n* Recent treatment in the target knee\n* Significant uncontrolled medical conditions\n* Hypersensitivity to study device components\n* Pregnancy or breastfeeding\n* Participation in another clinical trial",{"count":417,"type":22},180,[25],"This clinical trial aims to evaluate and compare the efficacy and safety of Conjuran® and Hyruan in patients with knee osteoarthritis following first and second cycle (repeat) administration.",[28],[422,252],"Polynucleotide sodium",{"date":312,"type":37},{"date":317,"type":22},{"date":426,"type":22},"2028-07",{"name":428,"class":213},"PharmaResearch Co.,Ltd",{"id":430,"slug":431,"hasResults":12,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":4,"eligibilityCriteria":435,"healthyVolunteers":389,"sex":17,"minAge":126,"maxAge":4,"enrollmentInfo":436,"targetDuration":4,"studyType":23,"phases":437,"briefSummary":439,"conditions":440,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":442,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":447,"locationsCount":72},"100609592","phase-4-zynrelef-versus-adductor-canal-block-100609592","NCT07216586","Zynrelef Versus Adductor Canal Block","Comparing Opioid Consumption Following Total Knee Arthroplasty With The Perioperative Administration of Zynrelef Versus Adductor Canal Block","Inclusion Criteria:\n\n* Patients \\> 18 years of age\n* Patients undergoing primary, unilateral total knee arthroplasty\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Individuals under the age of 18\n* Pregnant women\n* Prisoners\n* Adults unable to consent\n* American Society of Anesthesiologists Physical Status score greater than 3\n* Patients taking any of the following medications before surgery:\n* Long-acting opioids within 3 days\n* Any opioids taken within 24 hours\n* Bupivacaine HCL within 5 days\n* Chronic opioid use or patients with known or suspected daily use of opioids for seven or more consecutive days within 6 months before their scheduled surgery\n* Illicit drug use determined by social history\n* Alcohol abuse determined by a CAGE Substance Abuse Screening Tool Score of at least two or greater\n* Patients with a known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to any local anesthetic agent of the amide-type, NSAIDs, or to any of the other components of ZYNRELEF\n* Patients with a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients",{"count":83,"type":22},[438],"PHASE4","To compare postoperative MME consumption 72 hours after TKA in patients receiving intraoperative periarticular HTX-011 (Zynrelef) instillation versus adductor canal block.",[28,441],"Arthritis Knee",{"date":312,"type":37},{"date":444,"type":22},"2027-01",{"date":446,"type":22},"2028-01",{"name":448,"class":44},"University of Miami",{"id":450,"slug":451,"hasResults":12,"nctId":452,"briefTitle":453,"officialTitle":454,"acronym":4,"eligibilityCriteria":455,"healthyVolunteers":12,"sex":17,"minAge":126,"maxAge":19,"enrollmentInfo":456,"targetDuration":4,"studyType":23,"phases":457,"briefSummary":458,"conditions":459,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":462,"lastUpdatePostDateStruct":463,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":467,"locationsCount":72},"100539044","improving-total-knee-arthroplasty-dissatisfaction-through-a-personalized-approach-focusing-on-proms-phenotypes-100539044","NCT06298721","Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes","Improving Total Knee Arthroplasty Dissatisfaction at 1-year Through a Personalized Approach Focusing on PROMs Phenotypes: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Adult subject (Age \\>18 and \\\u003C 80 years of age)\n2. The subject is proficient in the English language\n3. The patient is voluntarily prepared to sign the 'Informed Consent Form'\n4. The patient is scheduled for a unilateral primary TKA\n5. TKA PROMs Phenotypes with higher risk of dissatisfaction\n6. Patient is willing and able to complete the protocol required follow-up\n\nExclusion Criteria:\n\n1. Patient requires simultaneous or staged bilateral knee replacements, staged \\\u003C90 days apart\n2. Patients undergoing revision TKA\n3. Inflammatory arthritis\n4. History of infection in the joint undergoing TKA\n5. Patient is considered a member of a protected population (e.g., prisoner, mentally incompetent, etc.)",{"count":283,"type":22},[25],"This study is a randomized controlled trial to assess whether the implementation of a TKA Personalized Outcome Prediction Tool to set expectation, in addition to targeted interventions to address patients with poor baseline mental health and poor physical function, improves satisfaction at 1-year (when compared to standard of care).",[28,460,461],"Knee Arthropathy","Surgery","2026-06-09",{"date":349,"type":37},{"date":465,"type":37},"2024-03-12",{"date":403,"type":22},{"name":468,"class":44},"The Cleveland Clinic",{"id":470,"slug":471,"hasResults":12,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":4,"eligibilityCriteria":475,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":80,"enrollmentInfo":476,"targetDuration":4,"studyType":23,"phases":477,"briefSummary":478,"conditions":479,"keywords":480,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":485,"startDateStruct":486,"completionDateStruct":487,"leadSponsor":489,"locationsCount":72},"100643601","effects-of-sahrmanns-approach-versus-conventional-treatment-oin-patients-with-knee-osteoarthritis-100643601","NCT07642258","Effects of Sahrmann's Approach Versus Conventional Treatment Oin Patients With Knee Osteoarthritis","Effects of Sahrmann's Approach Versus Conventional Treatment on Pain, Valgus Angle and Functional Disability in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Males and females between 40 to 60 years of age.\n* Diagnosed patients of knee Osteoarthritis with grade 2.\n* Valgus angle of knee \\> 10°.\n\nExclusion Criteria:\n\n* Any other inflammatory conditions.\n* Rheumatoid arthritis, ankylosing spondylitis or any other auto immune disorder",{"count":128,"type":22},[25],"Osteoarthritis (OA) of the knee, also referred to as degenerative joint disease, is normally due to wear and tear and progressive cartilage loss in the articular cartilage. Osteoarthritis is most prevalent condition among older adults. The objective of the study will be to compare the effects of Sahrmann's approach versus conventional treatment on pain, valgus angle and functional disability in patients with knee osteoarthritis.",[28],[481,482,483],"pain","functional disability","VALGUS ANGLE","2026-06-08",{"date":349,"type":37},{"date":39,"type":22},{"date":488,"type":22},"2026-10-01",{"name":490,"class":44},"Riphah International University",{"id":492,"slug":493,"hasResults":12,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":4,"eligibilityCriteria":497,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":80,"enrollmentInfo":498,"targetDuration":4,"studyType":23,"phases":500,"briefSummary":501,"conditions":502,"keywords":503,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":505,"startDateStruct":506,"completionDateStruct":508,"leadSponsor":510,"locationsCount":72},"100643058","effects-of-the-egoscue-exercises-with-and-without-mwm-among-patients-with-knee-osteoarthritis-100643058","NCT07646366","Effects of the Egoscue Exercises With and Without Mwm Among Patients With Knee Osteoarthritis","Effects of the Egoscue Exercises With and Without Mwm on Pain, Range of Motion, Balance, and Quality of Life Among Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* • Patients aged between 40-60 years (15)\n\n  * Both male and female genders\n  * Clinical and radiographic diagnosis of knee OA (Kellgren-Lawrence Grade II osteoarthritis)\n\nExclusion Criteria:\n\n* • Any fracture or other injury (18)\n\n  * Any inflammatory disease (Rheumatoid arthritis, gout) (18)\n  * Any neuropathy or neurological issue (18)\n  * History of knee surgery (18)\n  * Participation in other physical therapy programs within the last 3 months",{"count":499,"type":22},56,[25],"Knee osteoarthritis is a common degenerative joint disorder characterized by joint pain, stiffness, limited mobility, and reduced quality of life. It primarily affects the elderly population and poses a major burden on functional independence and healthcare resources. While various physiotherapy approaches have shown benefits in managing KOA symptoms, Mulligan's Mobilization with Movement is a manual therapy technique that has gained clinical attention for improving pain and joint mechanics. Similarly, Egoscue postural alignment exercises, which focus on restoring musculoskeletal balance through corrective movement patterns, have shown potential in addressing chronic pain and postural dysfunction, though evidence remains limited in knee osteoarthritis populations. This study aims to evaluate the effects of Egoscue exercises with and without MWM on pain, range of motion, balance, and quality of life in patients with knee osteoarthritis",[28],[504],"Osteoarthritis, pain, range of motion",{"date":312,"type":37},{"date":507,"type":22},"2026-05-30",{"date":509,"type":22},"2026-08-30",{"name":490,"class":44},{"id":512,"slug":513,"hasResults":12,"nctId":514,"briefTitle":515,"officialTitle":515,"acronym":516,"eligibilityCriteria":517,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":518,"targetDuration":520,"studyType":249,"phases":4,"briefSummary":521,"conditions":522,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":523,"startDateStruct":524,"completionDateStruct":526,"leadSponsor":528,"locationsCount":530},"100477312","innovations-in-genicular-outcomes-registry-100477312","NCT05495334","Innovations in Genicular Outcomes Registry","iGOR","Inclusion Criteria:\n\n1. Planned to receive treatment for knee OA pain including, but not limited to, knee injections, nerve blocking procedures, or knee arthroplasty within 60 days of screening\n2. Able to understand the informed consent and assessment questionnaires and have the ability to complete them in the opinion of the investigator\n3. Have access to a smartphone or internet access with a computer\u002Ftablet to complete the questionnaires using the registry application\n\nExclusion Criteria:\n\n1. Actively enrolled in an investigational trial that would preclude patients from receiving the site's standard of care for knee OA pain or knee arthroplasty recovery protocol\n2. Planning to have a surgery other than on the target knee",{"count":519,"type":22},10000,"18 Months","The registry will capture prospective data on patients receiving pain management for chronic pain due to knee osteoarthritis (OA) or pain optimization for knee arthroplasty due to knee OA. The OA pain therapies may include cryo nerve block, radiofrequency ablation (RFA), intra-articular (IA) corticosteroids, viscosupplementation, opioids, and others (e.g., non-steroidal anti-inflammatory drugs \\[NSAIDs\\]).",[28],{"date":462,"type":37},{"date":525,"type":37},"2021-09-23",{"date":527,"type":22},"2033-12-30",{"name":529,"class":213},"Pacira Pharmaceuticals, Inc",19,{"id":532,"slug":533,"hasResults":12,"nctId":534,"briefTitle":535,"officialTitle":536,"acronym":537,"eligibilityCriteria":538,"healthyVolunteers":389,"sex":17,"minAge":18,"maxAge":539,"enrollmentInfo":540,"targetDuration":4,"studyType":23,"phases":541,"briefSummary":542,"conditions":543,"keywords":551,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":556,"lastUpdatePostDateStruct":557,"startDateStruct":558,"completionDateStruct":560,"leadSponsor":562,"locationsCount":72},"100643382","the-act-on-a-geriatric-5-ms-guided-physical-therapy-intervention-for-knee-osteo-arthritis-in-older-adults-100643382","NCT07640529","The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults.","The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults: A Randomised Control Trial","5Ms\u002FPT\u002FKOA\u002FOA","Inclusion Criteria:\n\n* Prospective participants will be Saudi Nationals\n* aged 60 years or older\n* with a clinical diagnosis of knee osteoarthritis.\n* individuals must be capable of walking 10 meters independently or with an assistive device\n* self-report the ability to tolerate a one-hour assessment session.\n\nExclusion Criteria:\n\n* severe cognitive impairment\n* knee surgery within the past 6 months.\n* diagnosis of rheumatoid arthritis\n* the presence of unstable comorbidities (e.g., uncontrolled hypertension, heart failure, arrhythmia, severe pulmonary disease requiring oxygen, or a cardiac event in the past 6 months).\n* severe joint instability or deformity.\n* unmanaged severe osteoporosis.\n* a recent intra-articular corticosteroid injection (\\\u003C3 months).\n* active cancer treatment within the past 6 months.\n* non-elective hospitalization for a major illness.\n* surgery within the past 6 months.","90 Years",{"count":128,"type":22},[25],"The study is a Random control trail study conducted at King Khalid University Hospital in Riyadh, Saudi Arabia, focusing on Application of 5 framework in rehabilitation program of knee arthritis. The study will involve a in each group sample of 20 KOA patients, with a 12-month duration. The sample size was estimated using G\\*Power 3.1 software, and the initial power analysis indicated that 40 participants would be required to achieve 80.0% statistical power. The study's participants will be aged between 55 and 80 years, diagnosed with Knee osteoarthritis, without cognitive impairment, knee surgery in the past 6 months, or unstable comorbidities. The study will involve in-person 16 sessions, with the first two lasting approximately one hour and the remaining session 30-45 minutes. The main outcome measures that will be used in this study are Stay Independent Brochure, Iconographical Falls Efficacy Scale (icon-FES), Timed Up and Go, 2-Minute Walk Test, 5 Time Set to Stand Test AND Arthritis Self-Efficacy Scale 8 Item (ASES-8), Patient-Specific Functional Scale (PSFS), and Patient satisfaction level with Physical Therapy service MedRisk. Data will be taken from direct questions to patients, by filling out the questionnaire via Google Form, and through some tests and SPSS will be used for data analysis, with ANOVA Test intervention scores of the outcome measures.",[544,545,546,547,548,549,550,28],"Rehabilitation","Excercise","Geriatric","Physical Therapy","Rehabilitation Exercise","Rehabilitation Outcome","Knee Osteoarthristis",[552,553,554,555],"5Ms","PT","KOA","OA","2026-06-06",{"date":186,"type":37},{"date":559,"type":22},"2026-05-15",{"date":561,"type":22},"2026-10-15",{"name":563,"class":44},"King Saud University",{"id":565,"slug":566,"hasResults":12,"nctId":567,"briefTitle":568,"officialTitle":568,"acronym":4,"eligibilityCriteria":569,"healthyVolunteers":12,"sex":17,"minAge":126,"maxAge":4,"enrollmentInfo":570,"targetDuration":4,"studyType":249,"phases":4,"briefSummary":571,"conditions":572,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":586,"startDateStruct":587,"completionDateStruct":588,"leadSponsor":589,"locationsCount":4},"100643683","prospective-case-series-evaluating-6-month-and-12-month-outcomes-after-cryoneurolysis-for-chronic-pain-100643683","NCT07639060","Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain","Inclusion Criteria:\n\n* Diagnosis of chronic pain (generally pain duration of at least 3-6 months) localized to an anatomical region appropriate for cryoneurolysis as determined by the treating physician.\n* Planned cryoneurolysis procedure as part of standard clinical care.\n* Ability to provide written informed consent.\n* Ability and willingness to complete baseline and follow-up questionnaires.\n\nExclusion Criteria:\n\n* Cryoneurolysis performed as part of a separate investigational trial in which data sharing is not permitted.\n* Active infection or other clinical contraindication to the procedure as determined by the treating clinician.\n* Life expectancy of less than 12 months in the judgment of the treating clinician.\n* Any condition that, in the investigator's opinion, would interfere with study participation or completion of follow-up, such as severe psychiatric instability or active substance use that precludes reliable follow-up",{"count":21,"type":22},"To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.",[32,573,574,575,576,28,577,578,579,580,581,582,583,584],"PERIPHERAL NEUROPATHY","Occipital Neuralgia","Chronic Hip Pain","Hip Osteoarthritis","Spasticity","Chronic Low Back Pain","Lumbar Spondylosis","Cervical Spondylosis","Shoulder Arthritis","Causalgia","Chronic Pain Syndrome","Chronic Neck Pain","2026-06-05",{"date":186,"type":37},{"date":317,"type":22},{"date":426,"type":22},{"name":590,"class":44},"Yale University",{"id":592,"slug":593,"hasResults":12,"nctId":594,"briefTitle":595,"officialTitle":596,"acronym":4,"eligibilityCriteria":597,"healthyVolunteers":12,"sex":598,"minAge":599,"maxAge":53,"enrollmentInfo":600,"targetDuration":4,"studyType":23,"phases":601,"briefSummary":602,"conditions":603,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":604,"lastUpdatePostDateStruct":605,"startDateStruct":606,"completionDateStruct":607,"leadSponsor":609,"locationsCount":4},"100643742","effect-of-tecar-therapy-on-pain-balance-and-quality-of-life-in-elderly-men-with-knee-osteoarthritis-100643742","NCT07633795","Effect of TECAR Therapy on Pain, Balance, and Quality of Life in Elderly Men With Knee Osteoarthritis","Effect of TECAR Therapy on Pain, Balance, and Quality of Life in Elderly Men With Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Clinical and radiographic diagnosis of mild and moderate bilateral or unilateral knee osteoarthritis meeting the American College of Rheumatology (ACR) criteria.\n* Presence of chronic knee pain lasting for more than 6 months.\n* Ability to ambulate independently with or without an assistive device.\n\nExclusion Criteria:\n\n* Severe knee osteoarthritis (grade IV) requiring imminent surgical joint replacement.\n* History of previous knee arthroplasty, internal fixation, or significant trauma to the affected lower extremity.\n* Presence of pacemakers, metallic implants in the knee region, or severe. - peripheral vascular disease (absolute contraindications for TECAR therapy).\n* Intra-articular injections (corticosteroids, platelet-rich plasma, or hyaluronic acid) into the knee within the past 3 months.\n* Cognitive impairment or systemic inflammatory conditions (e.g., rheumatoid arthritis).","MALE","65 Years",{"count":21,"type":22},[25],"Evaluate the effect of TECAR therapy combined with traditional physiotherapy on pain, balance, and quality of life in elderly men with knee osteoarthritis .",[28],"2026-06-02",{"date":484,"type":37},{"date":289,"type":22},{"date":608,"type":22},"2026-10-18",{"name":610,"class":44},"Middle East University"]