[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"knee-pain-chronic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:knee-pain-chronic":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,43,77,105,131,157,190,221,244,269,295,326,347,376,400,421,449,469],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100525590","phase-2-perioperative-vitamin-c-to-reduce-persistent-pain-after-total-knee-arthroplasty-100525590",false,"NCT06123715","Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty","PeRiOperative VItamin C to Reduce perSistent paIn After tOtal kNee Arthroplasty (PROVISION): a Pilot Multicentre Randomized Controlled Trial","PROVISION","Inclusion Criteria:\n\n* Patients \\>18 years old\n* Undergoing a unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee\n\nExclusion Criteria:\n\n* TKA for infection (septic joint), fracture, ankylosing spondylitis, lupus, or psoriatic arthritis\n* History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency\n* Unlikely to comply with follow-up (e.g., no fixed address, plans to move out of town)\n* Language difficulties that would impede valid completion of questionnaires\n* Planned staged bilateral TKA\n* Treating surgeon deems patient inappropriate for inclusion in trial\n* Any allergy or sensitivity to milk\n* Pregnant or planning to become pregnant during the study","ALL","18 Years",{"count":20,"type":21},400,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.",[27,28,29],"Chronic Pain","Knee Pain Chronic","Post Operative Pain","RECRUITING","2026-06-19",{"date":33,"type":34},"2026-06-23","ACTUAL",{"date":36,"type":34},"2024-04-16",{"date":38,"type":21},"2027-12-31",{"name":40,"class":41},"University Health Network, Toronto","OTHER",3,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100577585","phase-2-pain-reprocessing-therapy-in-post-operative-knee-pain-100577585","NCT06800209","Pain Reprocessing Therapy in Post-Operative Knee Pain","Efficacy and Mechanisms of Pain Reprocessing Therapy in Chronic Post-Operative Knee Pain","REJOICE","Inclusion Criteria:\n\n* Patients are deemed eligible at 3 months post-operatively if: The patient completed a primary knee replacement \\[surgery completed without complication and patient exhibits full mechanical joint function, as determined by the treating physician (good range of motion, stability, and wound healing; absence of swelling)\\] and patient reports last week average knee pain ≥ 4 of 20 and at least two questions rated 'moderate' on A 12-item shortened version (ShortMAC) of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).\n* Reported pre-operative chronic knee pain of at least 6 months duration prior to surgery\n* The procedure was a primary (not a revision) knee replacement\n* Proficient in English\n\nExclusion Criteria:\n\n* Patients who are not willing to participate in a telehealth visit.\n* Patients with pre-op chronic pain but who do not have post-operative pain after the three month time period.\n* Active suicidal ideation with intent, recent history of suicide attempt, or self-harm behaviors within the past 5 years (including non-suicidal self-harm).\n* Recent history of inpatient psychiatric hospitalization within the past 5 years.\n* Active, current psychosis or mania.\n* Active, current substance abuse, or problems with substance abuse within the past 2 years.\n* Instability in living conditions or major interfering life events:\n\n  * Major surgery or other major medical event planned in coming 6 months.\n  * Uncertain whether they will have suitable conditions for telehealth appointments over the next 2 months, including access to a computer or tablet, reliable high-speed internet, and a quiet, comfortable room that is consistently available.\n  * Major, interfering changes in employment or housing anticipated over the next 6 months.\n* Neurological conditions (e.g., Alzheimer's, dementia, mild cognitive impairment, Huntington's disease, multiple sclerosis, cerebral palsy). This will be case-by-case decision made by PI to determine if the condition may interfere with treatment and warrant exclusion.\n* Self-reported diagnosis of an autoimmune disease (e.g., rheumatoid arthritis, polymyalgia rheumatica, scleroderma, lupus, polymyositis, or another autoimmune disorder).\n* Currently or plan to be involved in lawsuits related to pain in next 6 months, currently or plan to apply for any disability payments related to the pain in next 6 months, or received legal settlement or other disability payments related to the pain over past 2 years.\n\nEEG Exclusion Criteria (patients can still be enrolled as long as they meet all other eligibility criteria; however, they will not undergo EEG testing):\n\n* Are unable or uncomfortable with completing a dry cap EEG.\n* Has had a history of abnormal EEGs.\n* Had bilateral TKA",{"count":52,"type":21},110,[24],"The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery. The study is comparing PRT to usual care (the regular treatment people get after surgery) to see which works better for relieving pain.\n\nThe main questions the study aims to answer are:\n\n1. Does PRT help lower pain in people who have chronic knee pain after knee surgery?\n2. How do the effects of PRT compare with usual care in terms of pain relief and other factors such as anxiety, depression, and sleep?\n3. How does PRT impact the brain?\n\nParticipants will:\n\n1. Be randomly assigned to receive either PRT or usual care.\n2. Complete questionnaires about their pain and health.\n3. If in the PRT group, have eight weekly therapy sessions over video calls with a therapist.\n4. If interested, may also take part in an optional EEG test to measure brain activity related to pain.",[56,28],"Pain, Chronic",[58,59,60,61,62,63,64,65,66],"chronic pain","Pain Reprocessing Therapy","knee pain","total knee replacement","Total Knee Arthroplasty","mind-body","mindfulness","TKA","PRT","2026-03-30",{"date":69,"type":34},"2026-03-31",{"date":71,"type":34},"2025-08-13",{"date":73,"type":21},"2028-09-29",{"name":75,"class":41},"University of Colorado, Denver",2,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":76},"100485094","focused-extracorporeal-shockwave-therapy-for-knee-arthritis-100485094","NCT05596591","Focused Extracorporeal Shockwave Therapy for Knee Arthritis","Focused Extracorporeal Shockwave Therapy for Subchondral Bone Marrow Lesions in People With Knee Osteoarthritis: A Pilot Study","Inclusion Criteria:\n\n1. Males and females 30-80 years old, inclusive.\n2. Kellgren-Lawrence (KL) score grade 2-4 as diagnosed on X-Ray.\n3. Presence of BML(s) on MRI in a weight-bearing region of the knee (medial\u002Flateral femoral condyle or tibial plateau).\n4. Knee pain for more than 2 months.\n5. Knee pain intensity during the week leading up to the screening visit is at least 4 out of 10 on an 11-point numerical rating scale (NRS; 0, no pain; 10, maximum pain imaginable).\n6. Patient pain confined to the same compartment as the BML(s).\n7. Subjects would have failed a minimum of 4 weeks of conservative treatment including rest, analgesics, limited weight-bearing with or without an assistive device.\n\nExclusion Criteria:\n\n1. Traumatic BMLs.\n2. Primary cause of patient pain and loss of function is due to pathology other than BML(s), according to patient history and clinical evaluation.\n3. Presence of bilateral BML(s).\n4. Systemic autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis.\n5. Participants receiving glucocorticoids due to any other underlying disease.\n6. Prior treatment for BMLs including:\n\n   1. Subchondroplasty in the involved knee.\n   2. Intraosseous and\u002For intra-articular injection of orthobiologics in the past 6 months, such as platelet rich plasma (PRP), bone marrow aspirate concentrates, micro-fragmented adipose tissue (MFAT) or stromal vascular fraction.\n7. Prior use of bisphosphonates, except according to the washout schedule:\n\n   1. 2 years (if use \\> 48 weeks).\n   2. 1 year (if used \\> 8 weeks but \\\u003C 48 weeks)\n   3. 6 months (if used \\> 2 weeks but \\\u003C 8 weeks)\n   4. 2 months (if used \\\u003C 2 weeks)\n   5. Any intravenous bisphosphonate within the prior 2 years.\n8. Intra-articular steroid injection in the prior 3 months.\n9. Previous knee surgery in the past 6 months.\n10. Tumors\n11. Infection or fracture on ipsilateral lower limb.\n12. Pregnancy.\n13. Contraindications to f-ESWT, such as severe coagulopathy, malignant tumor in the treatment area.\n14. Contraindications to MRI scanning including:\n\n    * Presence of metal implants such as implanted pacemaker, metal sutures, metallic protheses (including metal pins and rods, heart valves), presence of shrapnel or iron filings in the eye, magnetic dental implants, cochlear implants, cerebral aneurysm clip, and deep brain stimulator.\n    * Claustrophobia.\n    * The patient has been informed by his\u002Fher doctor that it is medically unsafe to receive regular MRI as part of his\u002Fher medical care.","30 Years","80 Years",{"count":87,"type":21},15,[89],"NA","Subchondral bone marrow lesions (BMLs) in knee osteoarthritis (OA) are strongly associated with presence and severity of knee pain, structural deterioration, disease progression with an increased risk of total knee arthroplasty. OA-related BMLs may regress or resolve within 30 months which could be associated with long lasting disability. It has been reported that BMLs persist in the majority of knee OA patients. Different treatment strategies have been proposed including rest and protected weight-bearing, bisphosphonates, subchondroplasty and intraosseous orthobiologic injection. However, conservative treatment response takes a long time and other interventions may be considered invasive procedures that show varying results with several side effects. Focused extracorporeal shockwave therapy (f-ESWT) has been established as a safe non-invasive treatment with positive results in different bone disorders that share the same pathological features of BMLs. This is an exploratory, randomized-controlled, pilot study to determine the efficacy and safety of f-ESWT compared to the standard-of-care (analgesics and protected weight bearing) for the treatment of BMLs in patients with knee OA. Thirty subjects with knee OA who have history of knee pain at rest and during walking with the confirmed diagnosis of subchondral BML(s) on magnetic resonance imaging (MRI) despite at least 4 weeks of conservative treatment will be enrolled into this study. Subjects will receive a total of 4 sessions (at high energy level) over 4 consecutive weeks. Participants will be evaluated for adverse events and changes in pain intensity and knee function, using an 11-point numerical rating scale (NRS; 0-10, with anchors \"no pain\" and \"pain as bad as you can imagine\") and; the Knee injury and Osteoarthritis Outcome Score, respectively. Subjects will be assessed with these outcome measures at baseline, 1 month, 2 months, 3 months, and 6 months after the treatment. MRI of the involved knee will be performed prior to treatment (baseline) and 3 months and 6 months after treatment.",[92,93,28],"Bone Marrow Edema","Knee Osteoarthritis",[95],"Shockwave Therapy","2026-03-23",{"date":98,"type":34},"2026-03-27",{"date":100,"type":34},"2022-10-13",{"date":102,"type":21},"2027-12",{"name":104,"class":41},"Kessler Foundation",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":130},"100630989","images-identifying-metabolic-imaging-association-with-genicular-artery-embolization-success-100630989","NCT07494838","IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success","Inclusion Criteria:\n\n* Provided informed consent\n* Age ≥ 40 years\n* Ineligibility for or refusal of surgical management\n* Moderate-severe knee pain as determined by visual analog scale \\> 5 out of 10\n* Osteoarthritis based on X-ray. Kellgren-Lawrence score \\> 2 based on radiograph completed within 3 months of procedure date\n* Resistant\u002Ffailed some form of conservative treatment (e.g. NSAIDS\u002Fphysical therapy\u002Fsteroid joint injection\u002Fhyaluronic acid joint injection) for at least 3 months\n* Able to comply with all treatments and protocol follow-up visits\n\nExclusion Criteria:\n\n* Mild knee pain as determined by visual analog scale \\\u003C 5 out of 10\n* OA on knee radiograph resulting in greater than 20 degree varus or valgus angulation\n* Moderate loss of kidney function, define as estimated glomerular filtration rate of less than 45 mL\u002Fmin.\n* Significant arterial atherosclerosis that would limit selective angiography\n* History of fibromyalgia, autoimmune, or inflammatory disorder\n* History of any lumbar spine surgery, spine injections, or radicular pain in the extremity believed to originate from the spine\n* Allergy to iodinated contrast agents\n* Active infection or malignancy\n* Recent (within 12 months) or active cigarette use\n* Prior total or partial knee replacement in the subject knee\n* Active pregnancy\n* Uncorrectable bleeding diathesis\n* Presence of pacemakers, aneurysm clips, neurostimulators, or any other metal implant not compatible with PET\u002FMRI","40 Years",{"count":113,"type":21},25,[89],"Several clinical trials on genicular artery embolization (GAE) show significant clinical benefit for the majority of patients. However, a proportion of patients do not benefit from GAE, and responses vary across individual patients. Changes in metabolic activity on non-invasive imaging may correlate with improvement in symptoms of knee osteoarthritis. This study will assess changes in metabolic uptake on a hybrid positron emission tomography\u002Fmagnetic resonance imaging (PET\u002FMRI) system in subjects undergoing GAE.",[93,117,28,118],"Knee Discomfort","Knee Swelling Pain",[120],"GAE","NOT_YET_RECRUITING","2026-03-21",{"date":98,"type":34},{"date":125,"type":21},"2026-06-30",{"date":127,"type":21},"2027-06-30",{"name":129,"class":41},"Lucas R. Cusumano, MD",1,{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":130},"100628625","advanced-brain-imaging-tka-fmri-tka-100628625","NCT07464080","Advanced Brain Imaging-TKA (fMRI-TKA)","Brain Network-based Precision Medicine to Predict Dissatisfaction Following Total Knee Arthroplasty","fMRI-TKA","Inclusion Criteria:\n\n1. Male and female patients aged 18 years or older\n2. Primary TKA\n3. Diagnosis of osteoarthritis, inflammatory arthritis, or osteonecrosis\n\nExclusion Criteria:\n\n1. Inability or refusal to sign informed consent form\n2. Non-English or French speaking, and no licensed translator, family member or substitute decision maker available\n3. History of major neurological disorders (e.g traumatic brain injury, epilepsy, multiple sclerosis\n4. Cognitive impairment or dementia\n5. Revision and\u002For Bilateral TKA\n6. Chronic Opioid use",{"count":140,"type":21},50,[89],"Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges.\n\nThis study uses MRI scan of the brain to investigate whether specific patterns of brain activity can predict patient satisfaction after total knee arthroplasty (TKA). By comparing brain networks before surgery and afterward, and linking these changes to patient-reported pain and function, we aim to identify brain-based markers that can help predict outcomes, to improve satisfaction after knee replacement surgery.",[144,28,145,146,147],"Knee Osteoarthritis (Knee OA)","Brain Network Connectivity","Patient Satisfaction","Brain MRI","2026-03-09",{"date":150,"type":34},"2026-03-11",{"date":152,"type":21},"2026-04-01",{"date":154,"type":21},"2028-12-31",{"name":156,"class":41},"Ottawa Hospital Research Institute",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":164,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":167,"conditions":168,"keywords":177,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":189},"100499789","persona-osseoti-keel-compatibility-study-total-knee-arthroplasty-100499789","NCT05787821","Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)","Persona® OsseoTi® Keel Compatibility Study-A Multicenter Cohort Study A Prospective, Post-market Clinical Follow-up Study to Demonstrate Safety, Performance and Clinical Benefits of the Persona Knee System Portfolio and Its Instrumentation","Inclusion Criteria:\n\n1. Patient is of legal age and skeletally mature\n2. Patient is willing and able to provide written Informed Consent by signing and dating the Institutional Review Board (IRB) \u002F Ethics Committee (EC) approved Informed Consent document\n3. Patient is willing and able to complete scheduled follow-up evaluations as defined in the study protocol\n4. Independent of study participation, patient qualifies for either cemented or cementless primary or revision total knee arthroplasty (including salvage of previously failed surgical attempts) based upon physical exam and medical history, and meets the approved indications for use of the commercially available Persona Knee System with appropriately matched Zimmer Biomet components implanted in accordance with product labeling\n\nExclusion Criteria:\n\n1. Patient is currently participating in any other surgical intervention or pain management study\n2. Patient is pregnant or considered a member of a protected (vulnerable) population whose inclusion in the study is inappropriate (e.g. prisoner, mentally incompetent)\n3. Patient has a mental or neurological condition who is unwilling or incapable of following postoperative care instructions\n4. Patient has a condition which would, in the judgment of the investigator, place the patient at undue risk or interfere with the conduct of the study\n5. Patient is institutionalized or is a known drug abuser, a known alcoholic or cannot understand the requirements of study participation\n6. Patient is scheduled to undergo simultaneous bilateral total knee arthroplasty\n7. Previous history of infection in the affected joint and\u002For other local\u002Fsystemic infection that may affect the prosthetic joint\n8. Insufficient bone stock on femoral or tibial surfaces\n9. Neuropathic arthropathy\n10. Osteoporosis or any loss of musculature or neuromuscular disease that compromises the affected limb\n11. A stable, painless arthrodesis in a satisfactory functional position\n12. Severe instability secondary to the absence of collateral ligament integrity\n13. Rheumatoid Arthritis (RA) accompanied by an ulcer of the skin or a history of recurrent breakdown of the skin\n14. Patient has a \\> 5˚ valgus deformity with a medial collateral ligament (MCL) insufficiency, and the surgeon intends to use the personalized alignment surgical technique",{"count":165,"type":21},760,"OBSERVATIONAL","The main objective of the study is to evaluate the safety, performance and clinical benefits of the Persona implant and its instrumentation in primary total knee arthroplasty",[28,169,170,171,172,173,174,175,176],"Osteoarthritis, Knee","Rheumatoid Arthritis","Traumatic Arthritis","Polyarthritis","Varus Deformity","Valgus Deformity","Flexion Deformity of Knee","Avascular Necrosis",[178,62],"Osteoarthritis","2026-01-15",{"date":181,"type":34},"2026-01-20",{"date":183,"type":34},"2023-06-28",{"date":185,"type":21},"2035-06",{"name":187,"class":188},"Zimmer Biomet","INDUSTRY",16,{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":85,"enrollmentInfo":197,"targetDuration":4,"studyType":22,"phases":199,"briefSummary":200,"conditions":201,"keywords":204,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":76},"100597328","light-therapy-on-pain-and-synovitis-100597328","NCT07057063","Light Therapy on Pain and Synovitis","Effect of Light Therapy on Pain and Synovitis in Patients With Knee Synovitis: Study Protocol for a Randomized Controlled Trial","Inclusion Criteria:\n\n* Participants aged between 40 and 80 years\n* Able to provide written informed consent\n* Have experienced knee pain that persists or recurs for more than 3 months\n* A knee pain score of at least 30 mm on the 100-mm Visual Analogue Scale (VAS) during the past week\n* Ultrasound-measured knee synovitis ≥1\n* Presence of knee OA according to criteria established by the American College of Rheumatology\n\nExclusion Criteria:\n\n* Anticipated need for knee surgery within the next one year\n* Previous or planned knee replacement within the next one year\n* Knee surgery or other physical therapy in the previous 3 months\n* Use of intra-articular, intra-muscular, or oral corticosteroids in previous 4 weeks\n* Malignant tumors or other life-threatening diseases\n* Severe mental disorders, including but not limited to schizophrenia, bipolar disorder, or major depressive disorder, that may interfere with the participant's ability to comply with the study protocol or provide informed consent",{"count":198,"type":21},80,[89],"Background: Knee pain is a common complaint among middle-aged and older adults, often leading to reduced mobility and diminished quality of life. Synovitis is a major underlying cause, present in up to 80% of individuals with moderate knee pain. While light therapy has shown anti-inflammatory and analgesic effects in preclinical studies, our prior animal experiments revealed that light therapy at 810 nm significantly alleviated inflammation and pain-like behaviors. These findings suggest a potential wavelength-specific therapeutic effects. However, it remains unclear whether such effects can be replicated in humans. This study aims to evaluate the efficacy of 810 nm light therapy, compared to sham treatment, in reducing knee pain and synovitis in patients with chronic knee pain and knee synovitis.\n\nMethods\u002Fdesign:\n\nThis is a randomized, placebo-controlled clinical trial involving 90 participants with chronic knee pain and ultrasound-detected synovitis. Participants will be randomized into two groups to receive 810 nm light therapy, or sham therapy, delivered twice weekly over five weeks. Primary outcomes include knee pain assessed by the Visual Analogue Scale (VAS) and synovitis assessed by ultrasound. Secondary outcomes include the Knee injury and Osteoarthritis Outcome Score (KOOS), the 30-second chair stand test, and the 40-meter fast-paced walk test. Outcome assessments will be performed at baseline, post-intervention (week 5), and at 1 month and 6 months after treatment completion. Linear mixed-effects models will be used to compare outcome changes between groups.\n\nDiscussion:\n\nThis trial will assess whether 810 nm light therapy provides clinically meaningful benefits for reducing knee pain and synovitis in humans, building on promising preclinical findings. Results from this study may support the use of near-infrared light as a safe, non-invasive, and effective intervention for synovitis-related knee pain.",[28,202,203],"Synovitis of Knee","Light Therapy",[205,206,207,208,209,210,211],"Light therapy","Photobiomodulation","Chronic knee pain","Synovitis","Randomized controlled trial","Non-pharmacological intervention","physical therapy","2025-11-19",{"date":214,"type":34},"2025-11-26",{"date":216,"type":34},"2025-07-13",{"date":218,"type":21},"2026-05-28",{"name":220,"class":41},"The Hong Kong Polytechnic University",{"id":222,"slug":223,"hasResults":11,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":227,"eligibilityCriteria":228,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":85,"enrollmentInfo":229,"targetDuration":230,"studyType":166,"phases":4,"briefSummary":231,"conditions":232,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":4},"100605499","knee-pain-relief-after-endovenous-treatment-for-lower-limb-varicose-veins-a-prospective-observational-study-100605499","NCT07163312","Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study","Prospective Observational Cohort Study of Knee Pain and Function After Endovenous Treatment for Lower Limb Varicose Veins","VV-KNEE","Inclusion Criteria:\n\nAdults aged ≥18 years. Clinical diagnosis of lower limb varicose veins with documented venous reflux on duplex ultrasound (CEAP C2-C4).\n\nPresence of knee pain lasting ≥4 weeks prior to enrollment, confirmed by patient-reported VAS\u002FNRS ≥3 at baseline.\n\nPlanned to undergo standard endovenous treatment (radiofrequency ablation, endovenous laser ablation, or equivalent).\n\nAbility to provide informed consent and complete study questionnaires.\n\nExclusion Criteria:\n\nPrior surgery or endovenous ablation for varicose veins in the same limb. History of inflammatory arthritis (e.g., rheumatoid arthritis, gout) or other systemic rheumatologic disease.\n\nRecent acute knee injury (ligament, meniscus, fracture) within 6 months. Prior knee replacement or major knee surgery. Recent intra-articular injection or arthroscopy (\\\u003C3 months). Known deep vein thrombosis or history of pulmonary embolism within the past 6 months.\n\nSevere peripheral arterial disease (ABI \\\u003C0.8). Pregnancy or breastfeeding. Inability to comply with follow-up schedule or complete questionnaires.",{"count":140,"type":21},"6 Months","This study will observe patients with lower limb varicose veins who also have knee pain. Many patients with varicose veins experience swelling, heaviness, or aching in the legs, and some also report pain in or around the knee. Previous studies suggest that venous reflux and poor circulation may increase discomfort in the knee, especially when knee osteoarthritis is present.\n\nThe purpose of this study is to evaluate whether treatment of varicose veins with standard endovenous procedures can improve knee pain and function. Participants will undergo standard vein treatment as part of their clinical care. We will follow them for changes in knee pain, quality of life, and leg symptoms over time.\n\nThis study does not assign patients to experimental interventions. Instead, it collects information before and after treatment to better understand the relationship between varicose veins and knee pain relief. Findings from this study may help doctors identify which patients are most likely to benefit from venous treatment in terms of both leg and knee symptoms.",[233,234,28,93],"Varicose Veins of Lower Limb","Chronic Venous Insufficiency, CVI","2025-09-01",{"date":237,"type":34},"2025-09-09",{"date":239,"type":21},"2025-10-01",{"date":241,"type":21},"2026-11-01",{"name":243,"class":41},"Chengdu University of Traditional Chinese Medicine",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":250,"enrollmentInfo":251,"targetDuration":253,"studyType":166,"phases":4,"briefSummary":254,"conditions":255,"keywords":256,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":130},"100534501","the-effect-of-rf-genicular-nerve-block-applied-in-the-preoperative-period-on-fast-track-total-knee-arthroplasty-100534501","NCT06239649","The Effect of RF Genicular Nerve Block Applied in the Preoperative Period on Fast-track Total Knee Arthroplasty","Inclusion Criteria:\n\n* Being between the ages of 40 and 85,\n* Being able to understand verbal and written information given in Turkish,\n* Being able to speak and understand Turkish,\n* Being subjected to unilateral TKA surgery due to the diagnosis of Primary Knee osteoarthritis\n\nExclusion Criteria:\n\n* Patients planned for revision knee prosthesis surgery,\n* Patients previously diagnosed with psychiatric disorders,\n* Patients who have undergone major surgery on the extremity where TKA will be applied,\n* Patients with comorbid diseases such as rheumatoid arthritis or cancer,\n* Patients with a score above 3 according to the American Society of Anesthesiologists (ASA) scoring,\n* Patients with neurological diseases that cause functional disability,\n* Patients with flexion limitation of more than 45 degrees and extension limitation of more than 20 degrees,\n* Patients who have to use hypnotic or anxiolytic drugs regularly,\n* Patients with alcohol or drug addiction,\n* Patients with bleeding disorders\n* Patients with uncontrolled diabetes","85 Years",{"count":252,"type":21},60,"3 Months","In our study, investigators plan to compare the preoperative RF and genicular nerve ablation approach in patients who underwent TKA(Total Knee Arthroplasty) using the Fast-Track protocol in terms of meeting postoperative pain, function and early discharge criteria.",[93,28],[257,258,259],"Fast-Track Total Knee Arthroplasty","Genicular Nerve Block","Radiofrequency Ablation","2025-06-02",{"date":262,"type":34},"2025-06-04",{"date":264,"type":34},"2023-10-19",{"date":266,"type":21},"2025-06-01",{"name":268,"class":41},"Pamukkale University",{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":273,"acronym":274,"eligibilityCriteria":275,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":85,"enrollmentInfo":276,"targetDuration":4,"studyType":22,"phases":278,"briefSummary":279,"conditions":280,"keywords":282,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":294},"100551918","efficacy-of-microparticle-geniculate-artery-embolization-in-total-knee-prosthesis-patients-with-pain-resistant-to-medical-treatment-a-prospective-randomized-controlled-trial-100551918","NCT06466330","Efficacy of Microparticle Geniculate Artery Embolization in Total Knee Prosthesis Patients With Pain Resistant to Medical Treatment. A Prospective Randomized Controlled Trial","EPROGE","Inclusion Criteria:\n\n* Man or woman aged between 40 and 80 years with a TKR for more than one year.\n* TKR pain with a VAS ≥ 40 mm having progressed for at least 3 months despite the initiation of a well-conducted medical treatment including stage I and II analgesics and NSAIDs in the absence of contraindication.\n* Investigations within 6 months to rule out malposition, loosening and sepsis (conventional X-rays, bone scan, knee CT scan and biological work-up for inflammatory syndrome).\n* No revision surgery envisaged.\n* Echodoppler hyperemia over the painful area of the knee.\n* Subjects affiliated to social security.\n* Signed consent to the study.\n\nExclusion Criteria:\n\n* Local infection of the TKR or systemic infection.\n* Algoneurodystrophy.\n* Prosthesis loosening.\n* Neuropathic pain.\n* Allergy to contrast media.\n* Fibromyalgia.\n* Chronic or acute renal failure (clearance \\\u003C 30 ml\u002Fmn).\n* Hemostasis disorders (platelet count \\\u003C 50,000\u002Fmm3 or patient activated partial thromboplastin time (aPTT)\u002Fcontrol aPTT\\>1.2 or prothrombin ratio \\\u003C 50%).\n* Operative indication for removal of the prosthesis retained\n* Patient with severe obliterative arteriopathy of the lower limbs (Leriche et Fontaine stage 3).\n* Lidocaine contraindication: known hypersensitivity to lidocaine hydrochloride, amide-bonded local anesthetics or any of the excipients; patients with recurrent porphyria.\n* Vulnerable persons (minors, patients under guardianship or curatorship, deprived of liberty, under court protection, etc.).\n* Pregnant patients: for patients of childbearing age, a pregnancy test will be performed during the screening visit.",{"count":277,"type":21},112,[89],"The goal of this clinical investigation is to evaluate the effectiveness on pain of arterial occlusion (embolization) of neovessels by microparticle in a double-blind sham controlled randomised trial in patients with persistent pain on a total knee prosthesis (TKP), inserted for gonarthrosis, despite well-conducted medical treatment. The study patient population will consist of up to 112 subjects with knee pain for at least 3 months that is resistant to conservative treatment measures. Subjects will be treated with knee embolisation or saline in the sham arm. The efficacy of embolization will be judged on the basis of the following criteria: improvement in pain, mobility, use of pain medication, adverse effects of embolization and duration of improvement.\n\nAfter verification of eligibility criteria, patients with painful total knee prosthesis will be randomized to either the embolization group or the control group. Embolization will be performed using microparticles (Embozene® Microspheres 100 microns from Varian), for the treatment group. For the \"sham \" group, only diagnostic arteriography will be performed without injection of microparticles. Subjects will be followed up at 1, 3, 6 and 12 months.",[28,281],"Knee Pain Swelling",[283,284],"total hip replacement","pain","2025-05-26",{"date":287,"type":34},"2025-05-30",{"date":289,"type":34},"2025-03-10",{"date":291,"type":21},"2027-02-28",{"name":293,"class":41},"Societe Francaise de Rhumatologie",11,{"id":296,"slug":297,"hasResults":11,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":4,"eligibilityCriteria":301,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":302,"enrollmentInfo":303,"targetDuration":4,"studyType":22,"phases":305,"briefSummary":306,"conditions":307,"keywords":312,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":130},"100586437","biopoly-partial-resurfacing-knee-implant-ide-100586437","NCT06915363","BioPoly® Partial Resurfacing Knee Implant IDE","Pivotal, Prospective, Randomized, Controlled, Multicenter Clinical Trial of BioPoly® Partial Resurfacing Knee Implant for Treatment of Focal Cartilage Lesions of the Distal Femur","Inclusion Criteria:\n\n1. Patient is between 30 and 65 years of age25.\n2. KOOS quality of life score ≤ 60.\n3. In the opinion of the Investigator, the patient has the understanding and willingness to comply with all study requirements including the Post-Operative rehabilitation and follow-up protocol.\n4. Patient has cartilage lesion that has failed non-surgical conservative therapy (e,g, anti-inflammatory (NSAID), viscosupplementation, steroid injection, physical therapy, or activity modification) after at least 2 months of beginning the therapy or failed surgical conservative therapy (e.g. debridement\u002Flavage, marrow stimulation, or alignment high tibial osteotomy) that was performed at least 12 months ago in the index knee and is a candidate for surgical intervention.\n5. Patient has cartilage lesion located in the femoral condyle or trochlear facet.\n6. Patient has lesion(s) classified as ICRS grade 2, 3 or 4.\n7. Patient's lesion size may not exceed 3.1 cm2 and must be circumscribed by a 1.5 cm or 2.0 cm diameter circle, or 1.5 cm (M-L) by 2.4 cm (A-P) oval of normal or nearly normal (ICRS grade 0 or 1) cartilage, with an overall depth less than 4mm from the articulating surface.\n8. Patient has subchondral bone quality that is non-osteoporotic and is sufficient to support the implant. The quality of bone will be assessed by the surgeon intraoperatively with a surgical instrument such as an awl.\n\nExclusion Criteria:\n\n1. Patient has body mass index (BMI) ≥ 35.\n2. Patient has autoimmune arthritis, as diagnosed by Investigator.\n3. Patient has advanced degenerative osteoarthritis in index knee (Kellgren-Lawrence Grade 4 and\u002For diagnosed intraoperatively).\n4. Contralateral knee is known to have symptomatic cartilage, meniscal, or ligamentous lesions, generalized osteoarthritis, or requires surgery.\n5. Patient has gout, by Investigator diagnosis or patient-reported history within last 12 months.\n6. Patient has a cartilage lesion that is being treated with a non-surgical conservative therapy (e,g, anti-inflammatory (NSAID), viscosupplementation, steroid injection, physical therapy, or activity modification) and it has been \\\u003C 2 months since beginning treatment or the patient's cartilage lesion has failed surgical therapy (e.g. debridement\u002Flavage, marrow stimulation, alignment (high tibial osteotomy)) in the index knee and it has been \\\u003C 12 months since the surgical treatment.\n7. Patient has a cartilage lesion that is being treated that has failed ACI, OATS or Allograft treatment.\n8. Patient has malalignment of the index knee (\\>5 degrees weight bearing varus or valgus).\n9. Patient has bipolar articular cartilage involvement (or kissing lesions) of the ipsilateral compartment (i.e. greater than ICRS Grade 2 on the opposing articular surface) in the index knee.\n10. Patient has uncorrected ligamentous instability (good joint stability in the index joint with a Grade 1 Lachman or less, no pivot shift for ACL insufficiency and no posterior translation of more than grade 1; no deficits in flexion or extension of \\> 10 degrees compared to contralateral knee) in the index knee.\n11. Patient has undergone a total meniscectomy of index knee.\n12. Patient has undergone patellofemoral arthroplasty of the index knee\n13. Patient currently reports or has a documented history of uncontrolled diabetes.\n14. Patient currently has any condition, therapy, or medication known to impair bone healing.\n15. Patient has had an active systemic infection or joint infection in index knee over the last 12 months.\n16. Patient has an allergy to titanium alloy (Ti-6Al-4V), ultrahigh molecular weight polyethylene (UHMWPE), or hyaluronan\u002F hyaluronic acid (HA).\n17. Patient is pregnant or is planning to become pregnant (for female patients only) at any point during the duration of the study.\n18. Patient has legal involvement or any other issue that would hinder completion of the two-year follow-up period.\n19. Patient is participating in other studies and\u002For receiving any other simultaneous therapy in index knee.\n20. Patient has an uncorrected tear of the meniscus of the index knee. (Partial meniscectomy that retains \\>50% of the meniscus is allowed prior to or concurrently with the cartilage treatment procedure. Meniscus suture repair is allowed prior to or concurrently with the cartilage treatment procedure if \\>50% of the functional meniscus remains.).\n21. Patient has an additional cartilage lesion(s) (ICRS Grade 3 or 4) in the index knee, located on the patella, trochlea, tibia, or non-weight bearing area of index condyle that requires treatment.\n22. More than one implant is required to accommodate defect in the index knee.\n23. Patient has inadequate bone stock (e.g., cysts, osteoporosis) underlying the lesion site as determined intra-operatively by the investigator\n\n    1. As determined by the investigator through use of an awl or a similar instrument to determine if the bone quality is insufficient to support the BioPoly device.\n    2. If the cause of inadequate bone stock is due to cysts or to the boney portion of an osteochondral lesion being excessive, then the investigator may opt to fix the implant with cement rather than exclude the patient for inadequate bone stock.\n24. Patients with osteoporosis, osteopenia, Paget's disease, osteomalacia or any other metabolic bone disease; a. Osteoporosis is defined as Simple Calculated Osteoporosis Risk Estimation (SCORE) above 6 and DXA T-score \\\u003C -2.5 or QCT T-score \\\u003C 80mg\u002Fcubic cm. History of a fragility fracture requires that a DXA scan or QCT scan is completed","65 Years",{"count":304,"type":21},152,[89],"The goal of this randomized controlled clinical trial is to demonstrate the safety and effectiveness of the BioPoly® Partial Resurfacing Knee Implant for the treatment of cartilage defects of the distal femur in adult patients with knee pain and symptoms who are candidates for surgical intervention of the knee compared to outcomes for the control group.\n\nThe primary effectiveness endpoint is Month 24 composite clinical success (CCS) defined by:\n\n* no secondary surgical intervention (SSI) and\n* an improvement from baseline in the Knee injury and Osteoarthritis Outcome Score (KOOS) total score (scaled 0 to 100) of at least 10 points.\n\nResearchers will compare the CCS for the investigational device group to a control group receiving the standard of care, either microfracture or debridement).\n\nSubjects randomized to the investigational group will receive the BioPoly Knee device and those randomized to the control group will receive the current standard of care, either microfracture or debridement.",[28,93,308,309,310,311],"Cartilage Damage","Cartilage Defects of the Knee","Cartilage or Osteochondral Defects in the Knee","Cartilage Lesion",[313,314,315,316],"articular cartilage","cartilage lesion","focal cartilage defect","cartilage defect","2025-04-15",{"date":319,"type":34},"2025-04-17",{"date":321,"type":34},"2025-03-17",{"date":323,"type":21},"2028-12",{"name":325,"class":188},"BioPoly LLC",{"id":327,"slug":328,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":330,"acronym":331,"eligibilityCriteria":332,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":333,"targetDuration":4,"studyType":22,"phases":335,"briefSummary":336,"conditions":337,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":345,"locationsCount":130},"100443132","smart-embedded-intervention-for-military-postsurgical-engagement-readiness-100443132","NCT05050409","SMART Embedded Intervention for Military Postsurgical Engagement Readiness","SEMPER","Inclusion Criteria:\n\n* Scheduled to undergo unilateral total TKA at one of the study sites\n* TRICARE beneficiary\n* Facility with the English language that is adequate to complete study procedures.\n\nExclusion Criteria:\n\n* Cognitive impairment preventing completion of study procedures,\n* Formal mindfulness training (e.g., MBSR, MBCT)\n* Severe, active suicidality\n* Contralateral TKA in the past 3 months or planned contralateral TKA during the study\n* Current cancer diagnoses.",{"count":334,"type":21},500,[89],"The overarching objective of this proposal is to conduct a multi-site Sequential Multiple Assignment Randomized Trial (SMART) across multiple Military Health System (MHS) sites to optimize the sequencing and integration of two intervention strategies in total knee arthoplasty (TKA) patients: a single-session mindfulness-based intervention (MBI) and an intensive 8-week MBI-Mindfulness-Oriented Recovery Enhancement (MORE) designed to simultaneously reduce prolonged pain and chronic opioid use by enhancing self-regulation. Aim 1: Evaluate the extent to which a brief preoperative MBI improves TKA patients' postoperative musculoskeletal health and reduces chronic opioid use. Aim 2: Evaluate the extent to which an intensive MBI (MORE) improves musculoskeletal health and reduces chronic opioid use among patients non-responsive to preoperative intervention. Aim 3: (A) Determine patient baseline characteristics that moderate MBI treatment responses. (B) Quantify the degree to which the impact of Phase 1 and 2 MBIs on musculoskeletal health and opioid dose are mediated by changes in mechanistic autonomic marker of self-regulation: heart-rate variability (HRV).",[28],"2025-03-26",{"date":340,"type":34},"2025-03-27",{"date":342,"type":34},"2022-05-01",{"date":344,"type":21},"2027-10",{"name":346,"class":41},"University of Utah",{"id":348,"slug":349,"hasResults":11,"nctId":350,"briefTitle":351,"officialTitle":352,"acronym":4,"eligibilityCriteria":353,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":354,"enrollmentInfo":355,"targetDuration":4,"studyType":22,"phases":357,"briefSummary":358,"conditions":359,"keywords":365,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":130},"100424990","prospective-functional-gait-and-outcome-comparison-study-of-medial-pivot-versus-single-radius-design-for-total-knee-arthroplasty-100424990","NCT04814082","Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty","Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot","Inclusion Criteria:\n\n* Subject is male or non-pregnant female aged between 18 and 75 years of age.\n* Subject is willing to provide informed consent to participate in the research study.\n* Subject is indicated for a primary total knee arthroplasty (TKA) based on the approved labeling of knee implant, either a medial pivot or single radius design, specifically: MicroPort Evolution Medial-Pivot Knee System, Cruciate Retaining (CS) or Stryker Triathlon Tritanium (CS)\n* Subject does not have a history of previous prosthetic replacement device on the operative knee.\n* Subject is currently ambulating and does not have a condition on the contralateral limb in the opinion of the investigator that would interfere with the gait laboratory evaluations.\n* Subject is willing and able to comply with the schedule of events for the study and is available to return to the clinic for all required follow-up visits.\n\nExclusion Criteria:\n\n* Subject has a Body Mass Index (BMI) \\>40\n* Subject has a diagnosis of avascular necrosis or inflammatory arthritis.\n* Subject has any mental or neuromuscular disorder that would create an unacceptable risk of prosthesis instability, prosthesis fixation failure, or complications in postoperative care.\n* Subject is a prisoner\n* Subject has any condition, in the opinion of the Investigator that might interfere with the evaluation of the study objectives.","75 Years",{"count":356,"type":21},100,[89],"Patients with degenerative joint disease can effectively be treated with a primary total knee replacement to reduce pain and improve function in their daily lives. Theoretically, achievement of normal knee motion using a medial pivot design in total knee replacements can be recreated in comparison to single radius designs, which could lead to an improvement in post-surgical outcomes and satisfaction with the procedure. The aim of this study is to compare two types of implant designs (medial pivot and single radius) in a total knee replacement using clinical outcomes, patient reported outcomes, and overall function assessed by a specialized gait laboratory.",[169,93,360,361,362,28,363,364],"Osteoarthritis Knees Both","Osteoarthritis Knee Left","Osteoarthritis Knee Right","Knee Disease","Arthropathy of Knee Joint",[62,366],"Total Knee Replacement","2025-01-20",{"date":369,"type":34},"2025-01-22",{"date":371,"type":34},"2021-02-01",{"date":373,"type":21},"2030-07-01",{"name":375,"class":41},"LifeBridge Health",{"id":377,"slug":378,"hasResults":11,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":4,"eligibilityCriteria":382,"healthyVolunteers":383,"sex":17,"minAge":384,"maxAge":385,"enrollmentInfo":386,"targetDuration":4,"studyType":22,"phases":387,"briefSummary":388,"conditions":389,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":391,"lastUpdatePostDateStruct":392,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":130},"100524212","upper-and-lower-extremity-exercise-and-exercise-induced-hypoalgesia-in-knee-osteoarthritis-100524212","NCT06105788","Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis","Comparing Effects of Upper Extremity Versus Lower Extremity Exercise on Exercise-Induced Hypoalgesia in People With Knee Osteoarthritis: A Pilot Cross-over Study","Participants with knee OA (Target n=40)\n\nInclusion Criteria:\n\nWe will recruit participants with knee OA, using the National Institute for Health and Care Excellence's clinical diagnostic criteria, which does not require radiographs. The clinical diagnostic criteria include:\n\n* age ≥45\n* activity-related knee pain\n* either no morning joint-related stiffness or stiffness that lasts ≤ 30 minutes.\n* knee pain at least 4 on a 0-10 pain scale\n* knee pain as a chief complaint if having multiple pain\n* understand English\n\nExclusion Criteria:\n\n* peripheral neuropathy or other sensation loss on the body sites for pain measurements (i.e., the wrist, knee, the forearm)\n* use of medical devices electrically active (e.g., pacemaker)\n* chronic use of opioids\n* pregnant women\n* serious and uncontrolled concomitant disease, including cardiovascular, nervous system, pulmonary, renal, hepatic, metabolic, hormonal, endocrine, gastrointestinal or epileptic disease\n* rheumatoid arthritis, ankylosing spondylitis, and any neurological disorders that prevent the study procedure\n* cognitive impairment\n* history of a knee replacement surgery\n* inability to perform exercise due to severe pain or other symptoms\n* any intervention procedures for knee pain in the last 3 months\n\nInclusion and exclusion criteria for pain-free controls (Target n = 20) Pain-free controls are not having a pain-related medical condition. They have to speak and understand English. Pain-free controls are excluded if they had experienced a pain episode, caused by musculoskeletal injury or otherwise in the previous 3 months.",true,"45 Years","90 Years",{"count":252,"type":21},[89],"The objective of the study is to explore the effects of arm exercise (UE, arm ergometer) vs. leg exercise (LE, cycling ergometer) on exercise-induced hypoalgesia (EIH), central pain mechanisms and knee pain in people with knee osteoarthritis (OA). Furthermore, we will explore relations of socioeconomic status, racial discrimination, acculturative stress, and autonomic function to exercise effects on EIH, central pain mechanisms, and knee pain. This will be a pilot randomized cross-over study where all participants undergo Day 1 (baseline assessments), Day 2 (UE or LE), and Day 3 (UE or LE).",[93,28,390],"Central Pain Syndrome","2024-12-10",{"date":393,"type":34},"2024-12-16",{"date":395,"type":34},"2023-11-15",{"date":397,"type":21},"2025-10-16",{"name":399,"class":41},"University of Texas, El Paso",{"id":401,"slug":402,"hasResults":11,"nctId":403,"briefTitle":404,"officialTitle":404,"acronym":4,"eligibilityCriteria":405,"healthyVolunteers":383,"sex":17,"minAge":406,"maxAge":4,"enrollmentInfo":407,"targetDuration":4,"studyType":22,"phases":409,"briefSummary":410,"conditions":411,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":413,"startDateStruct":415,"completionDateStruct":417,"leadSponsor":419,"locationsCount":130},"100559876","evaluation-study-for-the-jockey-club-e-generation-impact-extension-project-for-chronic-knee-pain-management-100559876","NCT06569836","Evaluation Study for the \"Jockey Club E-Generation: Impact Extension Project for Chronic Knee Pain Management\"","Inclusion Criteria:\n\ni. Aged ≥55 years;\n\nii. Community-dwelling;\n\niii. With self-reported knee pain problem currently or in the past 12 months;\n\niv. Cognitively sound (screened by the Clock Drawing Test (CDT) ≤ 4 (Agrell \\& Dehlin, 1998));\n\nv. Able to understand and communicate in Cantonese or Mandarin.\n\nExclusion Criteria:\n\ni. Diagnosed with stroke, myocardial infarction, injury or inflammation of the knee, autoimmune disease, unable to walk in the past three months;\n\nii. Users\u002F of Hospital Authority medical consultation or physiotherapy or occupational therapy services related to osteoarthritis knee;\n\niii. Screened to have three or above conditions including significant knee symptom score 5 or above, WOMAC Score ≥48, 5 times Sit to Stand test \\>16.7 seconds, Time Up and Go Test \\>14 seconds, Age \\>80 and BMI \\>25.","55 Years",{"count":408,"type":21},858,[89],"Objectives:\n\nThis study aims to evaluate the effectiveness of the \"Jockey Club E-Generation: Impact Extension Project for Chronic Knee Pain Management\", with a view to developing sustainable strategies of self-management on chronic conditions integrating with tele-rehabilitation technology.\n\nStudy design and participants:\n\nAn evaluation study adopting a randomized controlled trial design, with waitlist attention control will be conducted in Elderly community centres of Hong Kong Sheng Kung Hui Welfare Council and Christian Family Service Centre (CFSC) in Hong Kong. The proposed sample size is 858 participants, which is a convenience sample from the service user of the \"Jockey Club E-Generation: Impact Extension Project for Chronic Knee Pain Management\". At least 15 participants will be invited for qualitative interview.\n\nParticipants will be randomized to the intervention group or the waitlist attention control group in 1:1 ratio using block randomization with random block size of 4, 6 and 8, stratified by each centre and severity of condition. A researcher independent to the project will generate the randomization sequence by computer and keep the list. Participants in the intervention group (known as Group A to the participants) will start the 12-week intervention immediately, whereas the waitlist attention control (know as Group B to the participants) will start the intervention after 12 weeks. During the waiting period, waitlist control receives attention control.\n\nMeasurements:\n\nThe primary outcome of this study is quality of life. It will be measured by the Hong Kong Chinese version of World Health Organization Quality-of-Life Scale (WHOQOL-BREF).\n\nThe secondary outcomes are pain, physical functioning, emotional functioning, adherence rate, satisfaction score, rate of adverse events in relation to the intervention, and cost-effectiveness of the intervention.\n\nExpected results:\n\nThe improvement in health-related quality of life of older adults is larger in the intervention group as compared to the control group; The relief in knee pain of older adults is larger in the intervention group as compared to the control group; The improvement in physical functioning of older adults is larger in the intervention group as compared to the control group; The improvement in emotional functioning of older adults is larger in the intervention group as compared to the control group.",[117,28],"2024-12-03",{"date":414,"type":34},"2024-12-05",{"date":416,"type":34},"2024-08-19",{"date":418,"type":21},"2026-09-30",{"name":420,"class":41},"The University of Hong Kong",{"id":422,"slug":423,"hasResults":11,"nctId":424,"briefTitle":425,"officialTitle":426,"acronym":427,"eligibilityCriteria":428,"healthyVolunteers":11,"sex":17,"minAge":429,"maxAge":385,"enrollmentInfo":430,"targetDuration":4,"studyType":22,"phases":432,"briefSummary":433,"conditions":434,"keywords":436,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":444,"completionDateStruct":446,"leadSponsor":447,"locationsCount":76},"100523359","rfa-or-chemical-neurolysis-of-the-genicular-nerves-compared-to-conservative-treatment-for-knee-pain-caused-by-oa-100523359","NCT06094660","RFA or Chemical Neurolysis of the Genicular Nerves Compared to Conservative Treatment for Knee Pain Caused by OA","Patients With Knee Pain Caused by Osteoarthritis: Comparison of Conservative Medical Management With RadioFrequency Ablation or Chemical Neurolysis of the Genicular Nerves With Phenol","RADIOPHENOL","Inclusion Criteria:\n\n1. Adult patients of both sexes, \\>35 years who are not a candidate for TKA due to young age, old age, comorbidity or technical reasons.\n2. OKS \\\u003C 30 on a scale from 0 (severe function) to 48 points (satisfactory function).\n3. Continued pain in the target knee that is moderate to severe (defined as NRS ≥ 6 on an 11-point NRS scale) either constantly or with motion despite at least 3 months of conservative treatments. Conservative treatment can include: active physiotherapy, pharmacological treatment of pain (acetaminophen or NSAIDs) and intra-articular corticosteroid infiltration.\n4. Radiologic confirmation of arthritis for the target knee. Defined as the Kellgren Lawrence (KL) score of 2 or more on X-ray or MRI.\n\nExclusion Criteria:\n\n1. Patient with prior ablation of the genicular nerves, prior partial, resurfacing, or TKA of the target knee (residual hardware).\n2. Patient with a history of neurovascular injury or recent trauma of the lower extremities.\n3. Patient with chronic widespread pain.\n4. Polyneuropathy and\u002For radicular pain in the lower extremities.\n5. Patient is currently implanted with a neurostimulator.\n6. Local or systemic infection (bacteraemia).\n7. Uncontrolled immune suppression.\n8. Intra-articular injections (steroids, hyaluronic acid, platelet enriched plasma, stem cell, …) in the target knee within 90 days from randomisation.\n9. Arthroscopic debridement\u002Flavage into the target knee within 180 days from randomisation.\n10. BMI\\\u003C18,5 kg\u002Fm2 and patients with minimal subcutaneous tissue thickness that would not accommodate ablation with phenol or radio frequency (risk of skin burns).\n11. Allergies to products used during the procedure (lidocaine, phenol, contrast dye).\n12. Patients who have a planned TKA in the near future, defined as patients who already have agreed on a date for the TKA procedure.\n13. Patients with psychosocial problems as determined by the investigator.","35 Years",{"count":431,"type":21},192,[89],"A randomised controlled triall (RCT) with three parallel arms comparing the functional outcome of chemical ablation with phenol and radiofrequency ablation (RFA) of the genicular nerves with conservative treatment in patients with chronic knee pain caused by osteoarthritis (OA).",[435,28],"Osteo Arthritis Knee",[437,438,439,440],"Pain","Thermal ablation","Phenol neurolysis","Genicular nerve","2023-12-04",{"date":443,"type":34},"2023-12-05",{"date":445,"type":34},"2023-11-27",{"date":241,"type":21},{"name":448,"class":41},"Dijklander Ziekenhuis",{"id":450,"slug":451,"hasResults":11,"nctId":452,"briefTitle":453,"officialTitle":453,"acronym":4,"eligibilityCriteria":454,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":250,"enrollmentInfo":455,"targetDuration":4,"studyType":22,"phases":457,"briefSummary":458,"conditions":459,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":465,"leadSponsor":467,"locationsCount":130},"100519030","optimizing-pain-self-management-in-total-knee-arthroplasty-100519030","NCT06038240","Optimizing Pain Self-Management in Total Knee Arthroplasty","Inclusion Criteria:\n\n* 18-85 years old.\n* Have a physician-confirmed treatment plan to undergo unilateral TKA along with physician-confirmed knee osteoarthritis diagnosis.\n* Willingness and ability to comply with scheduled sessions and study procedures\n\nExclusion Criteria:\n\n* Member of a vulnerable population including pregnant women, children, prisoners, cognitively impaired, and non-English-speaking subjects.\n* Current unstable, severe medical comorbidity.\n* Current severe psychiatric comorbidity (e.g., schizophrenia, psychosis, or other unstable psychiatric disorder).\n* Current severe alcohol or substance use disorder.\n* Weekly or more frequent use of opioids in the past 30 days (other than tramadol and\u002For codeine) for therapeutic or non-therapeutic purposes.\n* Other surgery of the affected knee in the last 6 months.\n* Previous TKA.",{"count":456,"type":21},150,[89],"The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee arthroplasty (TKA). The scientific premise is that patient use of a positive emotion generative practice - savoring meditation, which has been demonstrated to reduce pain in experimental laboratory settings, enhanced with a pain neuroscience education component about reward system dysfunction as a chronic pain mechanism - is optimally suited to reduce postsurgical pain and augment reward system functioning relative to a Pain Self-Management and Education (PSME) condition. We will randomize 150 patients with KOA undergoing unilateral TKA to a brief, 4-session (20-30 minutes each) course of Savoring Meditation (SM; n = 75) or PSME (n = 75) delivered remotely by trained interventionists in a one-on-one format. We will assess pain and as well as pain-related risk and protective factors both via questionnaire and via weeklong ecological momentary assessment (EMA) data bursts on the following schedule: baseline, post-surgery, and 3-month follow-up. In addition, participants will attend laboratory testing sessions at baseline and 6-weeks post-surgery, during which affective pain modulation and electroencephalographic (EEG) brain biomarkers associated with pain and affect will be recorded. Participants in SM be encouraged to practice their savoring for 5 minutes\u002Fday during the week following surgery, as well as to use it to manage pain flares in a self-directed manner.",[435,28,460],"Surgery","2023-11-29",{"date":463,"type":34},"2023-12-06",{"date":445,"type":34},{"date":466,"type":21},"2027-09",{"name":468,"class":41},"University of Virginia",{"id":470,"slug":471,"hasResults":11,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":4,"eligibilityCriteria":475,"healthyVolunteers":11,"sex":17,"minAge":476,"maxAge":477,"enrollmentInfo":478,"targetDuration":4,"studyType":22,"phases":480,"briefSummary":481,"conditions":482,"keywords":484,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":498,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":4},"100526385","finding-the-optimal-aim-of-correction-in-opening-wedge-high-tibial-osteotomy-100526385","NCT06134050","Finding the Optimal Aim of Correction in Opening Wedge High Tibial Osteotomy","Finding the Optimal Aim of Correction in Opening Wedge High Tibial Osteotomy Using 3D Printed Patient-specific Instrumentation (PSI). An RCT Comparing Correction Aimed at 62% Versus 55%.","Inclusion Criteria:\n\n* Patients having accepted and signed the informed consent form before surgery\n* Patients aged 30-60 years\n* Patients with an indication for primary HTO based on anamnestic, clinical and radiological findings leading to the diagnosis of major medial knee compartment overload symptoms\n* Mechanical varus axis of 3-9 deg. (calculated on full length weightbearing X-ray (FLWB))\n* Correctable angular deformity on the tibia only (medial proximal tibial angle (MPTA) + planned correction \\\u003C 95 deg. Lateral distal femoral angle (LDFA) \\\u003C92 deg.)\n* Maximal calculated gap height 14 mm\n* Only the first knee will be included if later contralateral HTO\n\nExclusion Criteria:\n\n* Inflammatory arthritis (Rheumatoid Arthritis, Bechterew arthritis, Psoriatic Arthritis)\n* Patients using Prednisolone perorally\n* Smokers (need to quit preoperatively)\n* Significant overweight (Body Mass Index \\> 35)\n* Earlier fractures in affected leg with fracture malalignment \\>5 deg.\n* Extension deficit \\>10 deg. in the affected knee\n* Earlier septic arthritis\u002Fosteomyelitis in the affected leg\n* Previous major surgery affecting leg function. Earlier knee arthroscopic procedures like ACL-reconstruction are not excluded\n* Planned combined procedures involving HTO + ACL\u002FPCL-reconstruction, meniscal transplantation or meniscal root fixation is excluded\n* Neurologic disease with symptoms affecting the leg\n* Serious illness or other factors that make communication, follow-up or rehabilitation difficult (e.g. alcohol or drug abuse, psychiatric disease, non-Norwegian speakers).","20 Years","60 Years",{"count":479,"type":21},70,[89],"The purpose of this RCT is to investigate whether high tibial osteotomy using 3D printed patient specific guides aiming at 55% correction is non-inferior to aiming at 62%.",[169,28,483],"Arthralgia",[485,486,487,488,489,490,491,492,493,494,495,496],"osteotomy","knee","osteoarthritis","3D print","PSI","High tibial osteotomy","Knee overload","Inertial measurement units","IMU","wearable sensors","gait analysis","accelerometer","2023-11-10",{"date":499,"type":34},"2023-11-18",{"date":501,"type":21},"2023-11",{"date":503,"type":21},"2028-10",{"name":505,"class":41},"Vestre Viken Hospital Trust"]