[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"labor-analgesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:labor-analgesia":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,44,73,110,133,159,181,208],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100615441","maternal-expectations-on-labor-analgesia-and-risk-of-postpartum-depression-an-observational-study-100615441",false,"NCT07292649","Maternal Expectations on Labor Analgesia and Risk of Postpartum Depression: An Observational Study","Inclusion Criteria:\n\n* Signed informed consent\n* Planned vaginal delivery (spontaneous or induced)\n* Pregnancy\n* Age \\> 18 years\n\nExclusion Criteria:\n\n* Allergy to local anesthetics\n* Language barrier\n* Contraindications to labor analgesia\n* Delivery by Cesarean section\n* Known history of psychiatric disorders (including major depression)","FEMALE","18 Years",{"count":18,"type":19},3640,"ESTIMATED","OBSERVATIONAL","Postpartum Depression (PPD) is defined as the development of depression at any time during the first year after childbirth¹. Its prevalence ranges from 15% to 20%. It can manifest with symptoms such as depressed mood, loss of interest and energy, insomnia, anxiety, and may even lead to suicidal ideation. The consequences are numerous, both physical and psychological, with long-term repercussions on the mother-infant bond, family dysfunction, and the development of emotional and cognitive disorders in children. The etiology of PPD is multifactorial, but numerous recent studies have focused on the role of labor pain and its management with labor analgesia techniques. The aim of the present study is therefore to assess whether there is a difference in the incidence of PPD between parturients whose expectations regarding labor analgesia were met ('expectations met' group) versus those whose expectations were unmet.",[23,24,25],"Postpartum Depression (PPD)","Labor Analgesia","Expectations",[27,28,29,30],"postpartum depression","labor analgesia","epidural","expectations","RECRUITING","2026-04-28",{"date":34,"type":35},"2026-04-29","ACTUAL",{"date":37,"type":35},"2026-01-08",{"date":39,"type":19},"2029-06",{"name":41,"class":42},"University of Padova","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":43},"100598813","phase-3-ropivacaine-and-fentanyl-for-labor-epidural-initiation-100598813","NCT07076368","Ropivacaine and Fentanyl for Labor Epidural Initiation","Determination of the 90% Effective Volume (ED90) of Epidural 0.1% Ropivacaine and Fentanyl for Labor Analgesia Initiation in Patients Receiving a Dural-Puncture Epidural Technique","EV90_DPE","Inclusion Criteria:\n\n* Patients with singleton vertex pregnancies in active labor (latent or spontaneous labor or after induction of labor)\n* Cervical dilatation between 2 and 7 cm\n* Requesting neuraxial labor analgesia\n* Age 18 or older\n\nExclusion Criteria:\n\n* Significant obstetric disease (e.g., pre-eclampsia, major cardiac disease)\n* Chronic pain or chronic opioid use\n* BMI ≥ 50\n* Multiple gestations\n* Allergy or anaphylaxis to local anesthetic\n* Fetal compromise or non-reassuring fetal trace\n* Age under 18\n* Inability to speak and understand English or Spanish",{"count":53,"type":19},50,"INTERVENTIONAL",[56],"PHASE3","This study is being done to determine the most effective dose of medicine to use to initially provide effective pain relief within the first 30 minutes of receiving an epidural for pain labor during labor. The study team will also study any side effects related to the epidural medication and patients' satisfaction with the quality of pain relief after receiving the epidural.",[59,60,24],"Pregnancy","Labor and Delivery",[29,28,62,63],"pregnancy","obstetric anesthesia","2026-01-23",{"date":66,"type":35},"2026-01-27",{"date":68,"type":35},"2025-10-24",{"date":70,"type":19},"2026-07-31",{"name":72,"class":42},"University of California, San Francisco",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":54,"phases":82,"briefSummary":84,"conditions":85,"keywords":97,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":43},"100607351","incidence-of-pruritus-using-intrathecal-fentanyl-versus-epidural-fentanyl-to-initiate-labour-analgesia-100607351","NCT07187427","Incidence of Pruritus Using Intrathecal Fentanyl Versus Epidural Fentanyl to Initiate Labour Analgesia.","Randomized Trial Comparing the Injection of Intrathecal Fentanyl Versus Epidural Fentanyl for the Initiation of Labour Analgesia on the Incidence of Pruritis.","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Vaginal delivery\n* Gestational age ≥ 37 weeks\n* Requesting neuraxial analgesia\n* French or English language\n\nExclusion Criteria:\n\n* ASA score \\> 3\n* Allergy or contraindication to receiving opioids\u002Flocal anesthesia (morphine or fentanyl)\n* BMI \\> 40 kg\u002Fm²\n* Hepatic or renal failure,\n* Severe preeclampsia and signs of severity according to the criteria of the American College of Obstetricians and Gynecologists\n* Maternal hemorrhage (placental abruption, hepatic subcapsular hematoma,...)\n* Severe scoliosis\n* Biliary cholestasis or polymorphic eruption of pregnancy\n* Inability to provide informed consent, either secondary to mental or physical disability or a significant language barrier (inability to understand English or French)\n* Prior administration of an opioid or opioid misuse",{"count":81,"type":19},80,[83],"NA","The purpose of this study is to investigate the effect of neuraxial analgesia initiation on the incidence of pruritus in laboring women. Specifically, this study aim to compare intrathecal fentanyl with epidural fentanyl in order to determine whether the epidural route is associated with a lower occurrence and severity of pruritus. By clarifying these differences, the research seek to optimize analgesic strategies during labor while minimizing opioid-related side effects",[86,87,88,89,90,91,24,92,93,94,95,96],"Pruritis","Hypotension Drug-Induced","Urinary Retention","Fetal Bradycardia During Labor","Nausea and Vomitting","Satisfaction, Patient","Neuraxial Opioid","Opioid Analgesic Adverse Reaction","Term Labour","Fentanyl Analgesia","Fentanyl Adverse Reaction",[98,99],"neuraxial opioid induced pruritus during labor","Intrathecal fentanyl versus Epidural fentanyl","NOT_YET_RECRUITING","2025-11-20",{"date":103,"type":35},"2025-11-26",{"date":105,"type":19},"2026-01",{"date":107,"type":19},"2027-05",{"name":109,"class":42},"St. Justine's Hospital",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":117,"sex":15,"minAge":16,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":54,"phases":121,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":43},"100509104","the-impact-of-needle-manipulation-and-accuracy-between-hand-held-automatic-and-traditional-ultrasound-device-100509104","NCT05909085","The Impact of Needle Manipulation and Accuracy Between Hand Held Automatic and Traditional Ultrasound Device","A Randomized Double Blinded Controlled Trial to Investigate the Impact of Needle Manipulation and Accuracy of Between Two Commercially Available Ultrasound Devices","Inclusion Criteria:\n\n* ASA-1, ASA-2, and ASA-3\n* Patients with no known back deformities\n* Ability to sit upright for epidural placement\n* No prior lumbar surgery\n* No allergies to ultrasound gel\n\nExclusion Criteria:\n\n* Coagulopathy\n* Low platelet count\n* Allergies to local anesthetics",true,"45 Years",{"count":120,"type":19},200,[83],"In this double blinded randomized controlled trial, the investigators would like to compare the effects on needle manipulation when relatively inexperienced sonographist (\\\u003C 1 year of ultrasound experience) perform ultrasound guided labor epidurals utilizing a traditional handheld ultrasound versus a handheld device that was engineered to provide automated guidance. The primary outcome of this study would be number of needle passes.",[24],"2025-09-10",{"date":126,"type":35},"2025-09-15",{"date":128,"type":19},"2026-07-01",{"date":130,"type":19},"2026-12",{"name":132,"class":42},"Yale University",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":15,"minAge":139,"maxAge":118,"enrollmentInfo":140,"targetDuration":4,"studyType":54,"phases":141,"briefSummary":142,"conditions":143,"keywords":144,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":43},"100539154","the-effect-of-ultrasound-real-time-guidance-technique-on-the-effectiveness-and-safety-of-labor-analgesia-100539154","NCT06300151","The Effect of Ultrasound Real-time Guidance Technique on the Effectiveness and Safety of Labor Analgesia","Inclusion Criteria:\n\n1. American Society of Anesthesiologists (ASA) Class I or II;\n2. Single healthy pregnancy;\n3. Head showing first;\n4. 37 to 41 weeks;\n5. The labor process is active, and the cervix dilates\\\u003C5cm;\n6. Require epidural labor analgesia;\n7. Volunteer to participate in this study and sign an informed consent form.\n\nExclusion Criteria:\n\n1. Presence of pregnancy diseases, such as pregnancy hypertension, pre eclampsia, pregnancy diabetes;\n2. Contraindications to intraspinal analgesia: 1) Central nervous system diseases. 2) Infection or septicemia at the puncture site. 3) Coagulation dysfunction;\n3. Known cases of fetal malformation or increased risk of cesarean section, such as a history of uterine rupture;\n4. Persons with a history of mental illness, hysteria, epilepsy, etc. who cannot cooperate.\n5. Patients with long-term use of opioids, steroids, and chronic pain.","20 Years",{"count":81,"type":19},[83],"Ultrasound real-time guidance technology has great advantages over traditional blind exploration technology in terms of accuracy, success rate, and reduction of puncture damage in intervertebral space positioning through operational visualization, greatly improving the effectiveness and safety of spinal block. At present, Doppler ultrasound is rarely used for spinal block, especially for real-time ultrasound guidance technology, which has not been widely applied in clinical practice due to its high equipment requirements, lack of mature puncture plans, complex operation, and high learning curve. If a comprehensive diagnosis and treatment plan can be developed, it will greatly improve the delivery experience of mothers.",[24],[145,28,146,147,148,149],"Ultrasound Real-time Guidance","delivery woman","neonate","Effectiveness","Safety","2025-08-18",{"date":152,"type":35},"2025-08-22",{"date":154,"type":35},"2024-04-01",{"date":156,"type":19},"2025-12-31",{"name":158,"class":42},"Zongxun Lin",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":117,"sex":167,"minAge":4,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":170,"conditions":171,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":43},"100599336","anesthesia-clinical-practice-during-labour-neuraxial-analgesia-100599336","NCT07083167","Anesthesia Clinical Practice During Labour Neuraxial Analgesia","Anesthesia Clinical Practice During Labour Neuraxial Analgesia: A Prospective Observational Study","ACP-LNA","Inclusion Criteria:\n\n* all obstetric anesthesiologists working in maternity unit\n\nExclusion Criteria:\n\n* any comorbidity of the patient that would necessitate deviation from a routine practice for the initiation of labor neuraxial analgesia","ALL",{"count":169,"type":19},19,"The goal of this observational study is to evaluate the communication between the anesthesiologist and the patient prior the initiation and during the administration of the labor neuraxial analgesia.\n\nThe investigators hypothesize that there will be differences among anesthesiologists during the informed consent process and communication during the procedure, specifically, how the anesthesiologists describe the technical aspects of the procedure, alternatives, risks, complications, and expected effects of labour neuraxial analgesia.\n\nThe anesthesiologists will be observed during a routine labor neuraxial analgesia procedure for healthy uncomplicated patients.",[24],"2025-07-15",{"date":174,"type":35},"2025-07-24",{"date":176,"type":35},"2025-04-02",{"date":178,"type":19},"2025-12-30",{"name":180,"class":42},"University of British Columbia",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":188,"targetDuration":4,"studyType":54,"phases":190,"briefSummary":191,"conditions":192,"keywords":196,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":206,"locationsCount":43},"100593531","effects-of-ropivacaine-concentrations-on-prolonged-labor-analgesia-100593531","NCT07007650","Effects of Ropivacaine Concentrations on Prolonged Labor Analgesia","Effects of Different Concentrations of Ropivacaine on Prolonged Labor Analgesia","Inclusion Criteria:\n\n1. ASA II\n2. Age ≥ 18 years\n3. Singleton pregnancy\n4. No contraindications for epidural puncture and voluntarily accepting labor analgesia\n5. Maternal participants changing the first pump fluid\n\nExclusion Criteria:\n\n1. Contraindications for epidural labor analgesia\n2. Serious heart, brain, liver, or kidney diseases\n3. Mental abnormalities\n4. Neurological diseases\n5. Maternal request for management of breakthrough pain before changing the pump fluid",{"count":189,"type":19},100,[83],"With the changes in medical models and improvements in people's quality of life, parturients have higher demands for childbirth, making the alleviation and elimination of labor pain an important aspect of modern obstetrics. Intrathecal labor analgesia has been widely adopted in clinical practice to relieve pain. However, current studies mainly focus on parturients who are just beginning to receive labor analgesia, while for those experiencing prolonged analgesia, medical institutions still use traditional formulations, lacking relevant guidelines or expert consensus. In such cases, prolonged waiting and anxiety may lower the pain tolerance of parturients, leading to an increased need for higher concentrations of local anesthetics. To address this clinical gap, this study aims to explore the effects of different concentrations of ropivacaine in prolonged labor analgesia and has designed a prospective randomized controlled trial (RCT) to provide evidence for improving the analgesic regimen for this group of parturients.",[24,193,194,195],"Prolonged","Ropivacaine","Concentration",[24,197,198,199],"Ropivacaine Concentration","Prolonged Pain","Maternal-Neonatal Safety","2025-06-05",{"date":202,"type":35},"2025-06-06",{"date":204,"type":19},"2025-06-14",{"date":124,"type":19},{"name":207,"class":42},"Chengdu Jinjiang Maternity and Child Health Hospital",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":117,"sex":15,"minAge":16,"maxAge":118,"enrollmentInfo":215,"targetDuration":4,"studyType":54,"phases":217,"briefSummary":218,"conditions":219,"keywords":220,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":43},"100562382","effect-of-epidural-catheter-retention-depth-on-labor-analgesia-performed-in-dpe-combined-with-pieb-model-100562382","NCT06602440","Effect of Epidural Catheter Retention Depth on Labor Analgesia Performed in DPE Combined With PIEB Model","Observations on the Effect of Different Depths of Epidural Catheter Retention on the DPE Technique Combined With the PIEB Mode of Labor Analgesia：a Single-center, Prospective, Randomized Controlled Study","Inclusion Criteria:\n\n1. Those aged 18 to 45 years old;\n2. Pregnancy lasts for 37 to 42 weeks;\n3. Single healthy pregnant women with cervical dilation \\\u003C 3.0 cm who wish to use epidural labor analgesia;\n4. The NRS score of uterine contraction pain is \\> 3;\n5. ASA grade I-II;\n6. BMI ≤ 40 kg\u002Fm².\n\nExclusion Criteria:\n\n1. Those with contraindications to intraspinal anesthesia;\n2. Those with a history of allergy to local anesthetics and opioids;\n3. Pregnancy diseases (such as pregnancy-induced hypertension, preeclampsia or gestational diabetes, etc.);\n4. Known fetal abnormalities or situations associated with an increased risk of cesarean section;\n5. Patients who have taken opioids or sedatives within 4 hours before epidural analgesia.",{"count":216,"type":19},102,[83],"The purpose of this study is to observe the appropriate indwelling depth of epidural catheter when labor analgesia is performed in the mode of DPE combined with PIEB, and then shorten the onset time of labor analgesia and reduce the occurrence of catheter-related adverse outcomes.",[24],[221,222,223],"Uterine contraction pain","Dural puncture epidural technique（DPE）","Programmed intermittent epidural bolus（PIEB）","2024-09-17",{"date":226,"type":35},"2024-09-19",{"date":228,"type":35},"2024-07-01",{"date":230,"type":19},"2024-10-01",{"name":232,"class":42},"General Hospital of Ningxia Medical University"]