[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"labor-dystocia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:labor-dystocia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,80,109,135,164],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100570086","phase-2-anticholinergics-for-cervical-edema-in-labor-100570086",false,"NCT06702670","Anticholinergics for Cervical Edema in Labor","Anticholinergics for Cervical Edema in Labor (ACCEL)","ACCEL","Inclusion Criteria:\n\n* Primiparous\n* Viable single intrauterine pregnancy\n\n  -≥ 34 weeks of gestation\n* Ruptured membranes\n* Category I tracing at time of inclusion\n* Active phase of labor (\\>=6 cm of cervix dilation)\n\nExclusion Criteria:\n\n* Category II or III tracing\n* Allergy to the study medication (IV Diphenhydramine)","FEMALE","18 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE2","PHASE3","The purpose of this study is to is to determine the clinical effectiveness of a single dose of intravenous (IV) medication for the prevention of labor arrest and cesarean delivery in primiparous women undergoing trial of labor.",[28],"Labor Dystocia",[30,31],"dilation","labor","RECRUITING","2026-05-04",{"date":35,"type":36},"2026-05-06","ACTUAL",{"date":38,"type":36},"2025-03-25",{"date":40,"type":21},"2027-04-09",{"name":42,"class":43},"The University of Texas Health Science Center, Houston","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100617650","efficacy-of-bicarbonate-on-the-risk-of-assisted-delivery-in-nulliparous-women-with-prolonged-labour-100617650","NCT07321379","Efficacy of Bicarbonate on the Risk of Assisted Delivery in Nulliparous Women With Prolonged Labour","Efficacy of Bicarbonate on the Risk of Assisted Delivery in Danish Nulliparous Women With Prolonged Labour: a Double-blinded Parallel Randomized Controlled Trial (The ProLabour Trial)","ProLabour","Inclusion Criteria:\n\n* Age ≥18 years.\n* Danish or English speaking.\n* Cephalic presentation.\n* Gestational age ≥34+0 - \\\u003C42+0 (days +weeks) at onset of labour.\n* Normal foetal heart rate pattern in the 20 minutes prior to inclusion.\n* Spontaneous onset of labour or non-medical induced labour (balloon catheter and\u002For artificial rupture of membranes).\n* Active first stage of labour confirmed, according to Danish national guidelines: Cervical dilatation at ≥4 - \\\u003C10 cm with regular painful contractions.\n* Prolonged labour diagnosed, according to Danish national guidelines: Cervical dilatation progresses at less than 2 cm over a 4-hour period.\n\nExclusion Criteria:\n\n* Clinical suspicion of infection (2 confirmed temperatures ≥38.5°C with epidural, ≥38 °C without epidural, or broad-spectrum antibiotics initiated)\n* Significant medical comorbidity in the form of renal or heart condition, assessed case-by-case basis.\n* Serious obstetric complication\n* Known allergy or intolerance to sodium bicarbonate.\n* Ingestion of sodium bicarbonate in active labour prior to inclusion.\n* Current treatment with following medicines: Gabpabpentin, Tetracycline, Ketoconazole (NB! These medications are already generally advised contradicted against induring pregnancy)","50 Years",{"count":55,"type":21},1520,[57],"NA","The goal of this clinical trial is to learn if oral bicarbonate can treat prolonged labour in nulliparous women with prolonged labour.\n\nThe main question it aims to answer is: Do oral bicarbonate and restrictive oxytocin use reduce assisted delivery rate (emergency cesarean and vacuum\u002Fforceps delivery) in nulliparous women with prolonged labour.\n\nResearchers will compare bicarbonate and placebo (a look-alike substance that contains no drug) to see if bicarbonate works to treat prolonged labour.\n\nParticipants will:\n\n* drink bicarbonate or placebo\n* have cervical dilatation reassessed after 2 hours. If still slow progression, they will follow standard protocol for oxytocin augmentation\n* will receive a questionnaire 1 month post partum to assess birth experience\n\n1\u002F3 of participants will have amniotic fluid lactate measured at inclusion and after 2 hours",[60,28],"Prolonged Labor",[62,63,64,65,66,67,68],"Labor","Bicarbonate","Caesarean section","Assisted birth","Oxytocin","Labor augmentation","Intrapartum","NOT_YET_RECRUITING","2026-01-08",{"date":72,"type":36},"2026-01-12",{"date":74,"type":21},"2026-02-01",{"date":76,"type":21},"2028-01-31",{"name":78,"class":43},"Copenhagen University Hospital, Hvidovre",3,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":44},"100560717","phase-4-calcium-carbonate-to-augment-labor-contractions-100560717","NCT06580782","Calcium Carbonate to Augment Labor Contractions","CALC","Inclusion Criteria:\n\n* 18 years or older\n* Nulliparas (no prior pregnancy lasting 20 weeks or greater of gestation)\n* Gestational age above 36 weeks, at enrollment\n* Present for induction or augmentation of labor inclusive of medical indication, elective induction at greater than 39 weeks' gestation, trial of labor after cesarean\n* Singleton gestation (a multiple gestation reduced to a singleton, either spontaneously or therapeutically, before 14 0\u002F7 weeks of gestation is acceptable)\n* Ability to give informed consent\n* Planned to undergo initiation of oxytocin infusion by their maternity care provider\n\nExclusion Criteria:\n\n* Unable to understand or read English\n* Presence of tachysystole (defined as more than 5 contractions in 10 minutes averaged over 30 minutes), recurrent variable or late fetal decelerations, and bradycardia in the prior 30 minutes before enrollment\n* Non-vertex presenting fetus at enrollment\n* Planned for cesarean delivery or contraindication to labor by institutional policy (e.g., placenta previa, vasa previa, active genital herpes infection, previous transmural myomectomy)\n* Multi-fetal gestation (twins, triplets, and higher order multiples)\n* Known contraindication to taking calcium carbonate including renal calculus, high urine calcium levels, elevated serum calcium, low serum phosphate, achlorhydria, or suspected digoxin toxicity.\n* Deliveries with fetal chronic and\u002For pregnancy-related conditions, IUFD (Intra Uterine Fetal Death) or premature \\< 36 weeks of gestation.\n* Major fetal anomaly suspected prenatally (defined as a fetal anomaly with anticipated neonatal intensive care unit admission)\n* Suspected alloimmunization (given the increased likelihood for anticipated neonatal intensive care unit admission)\n* Known severe fetal growth restriction (estimated fetal weight \\<3rd percentile) or abnormal umbilical artery Doppler studies (given the increased likelihood for anticipated neonatal intensive care unit admission)\n* Participation in another interventional study that influences management of labor and delivery or perinatal morbidity or mortality\n* Known allergic reactions to synthetic oxytocin intravenous solution or to Calcium Carbonate\n* Significantly impaired consciousness or executive function (e.g., intubated or sedated)\n* Patients treated with calcium channel blockers such as nifedipine or magnesium.\n* Chronic renal failure and hyperphosphatemia.\n* Inability to tolerate oral intake (i.e., nausea\u002Fvomiting)",true,{"count":89,"type":21},60,[91],"PHASE4","The investigators think that calcium carbonate can act as an assistive medication to improve contractions during labor.",[28,94,95],"Labor Induction","Labor Augmentation",[62,97,95,98,99],"Pregnancy","Calcium Carbonate","labor induction","2025-10-21",{"date":102,"type":36},"2025-10-23",{"date":104,"type":36},"2024-11-18",{"date":106,"type":21},"2025-12",{"name":108,"class":43},"Weill Medical College of Cornell University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":87,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":118,"conditions":119,"keywords":122,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":44},"100506995","early-diagnosis-and-intervention-for-fetal-malposition-in-active-labor-and-its-impact-on-mode-of-delivery-100506995","NCT05881629","Early Diagnosis and Intervention for Fetal Malposition in Active Labor and Its Impact on Mode of Delivery","Early Diagnosis and Intervention for Fetal Malposition in Active Labor and Its Impact on Mode of Delivery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Maternal age \\>18\n* Term gestation (\\>37 weeks)\n* Singleton pregnancy\n* Spontaneous or induced active labor (cervical dilation 6-9cm)\n* Epidural anesthesia\n* Cephalic fetal presentation, OP\u002FOT position diagnosed by bedside ultrasound\n* Continuous external fetal monitoring\n* Ability to consent\n\nExclusion Criteria:\n\n* Multiple gestations\n* Unanesthetized labor\n* Known fetal anomalies\n* Known intrauterine fetal demise\n* Inability to consent",{"count":20,"type":21},[57],"The goal of this randomized trial is to test if changing a person's position in labor can increase the chances of delivering their baby vaginally.\n\nSpecifically, it aims to answer the questions:\n\n* In fetuses who are facing upwards (occiput posterior, OP) or sideways (occiput transverse, OT) during labor, does changing the patient's position during active labor to a side-lying posture with a peanut ball increase the chances of them having a successful, spontaneous vaginal delivery?\n* Does changing the patient's position in active labor affect the position of the baby at the time of delivery?\n* Do intentional position changes in labor impact patient-perceived autonomy during their labor and delivery experience?\n\nParticipants will:\n\n* Receive an ultrasound during labor to determine the position of their baby\n* Be asked to adopt a specific position in labor (side-lying with peanut ball) if they are randomized to the study group\n* Receive additional ultrasounds during labor to assess their baby's position\n* Fill out a questionnaire about their labor experience following the delivery of their baby",[120,28,121],"Cesarean Delivery Affecting Fetus","Labor Complication",[123,124,125],"fetal malposition","occiput posterior","occiput transverse","2025-09-03",{"date":128,"type":36},"2025-09-11",{"date":130,"type":36},"2024-05-01",{"date":132,"type":21},"2026-09-01",{"name":134,"class":43},"Women and Infants Hospital of Rhode Island",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":87,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":22,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":163},"100500082","the-norwegian-world-health-organisation-labour-care-guide-trial-norwel-100500082","NCT05791630","The Norwegian World Health Organisation Labour Care Guide Trial (NORWEL)","The Norwegian World Health Organisation Labour Care Guide Trial","NORWEL","Inclusion Criteria:\n\n* Women in active labour\n* Labour and delivery at study sites\n\nExclusion Criteria:\n\n* None",{"count":144,"type":21},23650,[57],"Appropriate and timely care during birth is critical to the survival and health of women and their babies. In 2020, the World Health Organization (WHO) presented the Labour Care Guide (LCG) as the new recommended tool for monitoring birth and assessing progression, replacing the WHO partograph. This evidence-based guide was designed to ensure improved quality and safety of care, and to avoid unnecessary interventions during birth. The LCG was developed to be used in all settings globally, but it has only been tested in health facilities in South America, Asia and Africa, while it has not been tested in high-income settings. Implementing a new guideline for monitoring birth is a comprehensive operation that will affect both the national economy, health systems, and individual patients; therefore, further research on the possible advantages is needed before national enrolment. Hence, the trial proposed in this application is crucial to form the required foundation of knowledge. The trial will be conducted in labour wards at ten hospitals, covering all health regions in Norway, and the established Norwegian Research Network for Clinical Studies in Obstetrics (NORBIRTH), with dedicated local principal investigators, will provide a robust research environment. This trial will test the effect of the LCG. Results from this trial will provide knowledge needed to determine a future implementation of the LCG in Norway.",[28,121,148,149,150,151,152,153],"Labor Onset and Length Abnormalities","Labor (Obstetrics)--Complications","Experience, Life","Progression","Cesarean Section Complications","Apgar; 4-7 at 1 Minute","2025-04-02",{"date":156,"type":36},"2025-04-04",{"date":158,"type":36},"2025-04-01",{"date":160,"type":21},"2030-12-31",{"name":162,"class":43},"Ostfold Hospital Trust",10,{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":22,"phases":175,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":44},"100536715","oxytocin-rest-to-reduce-cesarean-delivery-100536715","NCT06268431","Oxytocin Rest to Reduce Cesarean Delivery","Oxytocin Rest to Reduce Cesarean Delivery in Prolonged Labor: An Open-Label, Randomized Controlled Trial","ORCA","Inclusion Criteria:\n\n* ≥18 years of age\n* Singleton gestation in vertex presentation\n* ≥36 weeks gestation\n* Prolonged latent labor, defined as cervical dilation \\\u003C6cm after ≥8 hours since rupture of membranes and on continuous oxytocin\n\nExclusion Criteria:\n\n* Not meeting the above criteria\n* Any contraindication to continuous oxytocin at time of randomization\n* Cesarean section anticipated by the clinical team at time of randomization (for any reason excepting labor dystocia)\n* \\>18 hours between rupture of membranes and randomization\n* Known intraamniotic infection at randomization\n* Fetal demise\n* Any contraindication to vaginal delivery\n* Maternal eclampsia","55 Years",{"count":174,"type":21},350,[57],"Prolonged labor is usually managed with continuous oxytocin infusion. \"Oxytocin rest\" has been proposed as a strategy to resolve protracted labor in patients who have received continuous oxytocin without progress. This strategy involves discontinuing oxytocin then restarting infusion after a period of time, under the theory that washout of the oxytocin receptor will strengthen uterine contractions to improve labor progress. \"Oxytocin rest\" is performed on labor and delivery units across the United States. Yet, there is no randomized or prospective data to support the practice.\n\nThe purpose of this study is to assess whether oxytocin rest of 60 minutes in patients with prolonged labor reduces risk for cesarean delivery.",[60,178,28],"Failed Induction","2024-10-15",{"date":181,"type":36},"2024-10-17",{"date":183,"type":36},"2024-03-19",{"date":185,"type":21},"2026-03-15",{"name":187,"class":43},"Christiana Care Health Services"]