[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"labor-induced\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:labor-induced":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,48,76,97,128,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100561521","membrane-stripping-for-cervical-ripening-100561521",false,"NCT06591247","Membrane Stripping for Cervical Ripening","Evaluation of Stripping for Cervical Ripening - A Randomized Controlled Study","Stripping","Inclusion Criteria:\n\n* Patients aged 18 and above\n* Patients with a cervical dilation of at least 1 cm\n* Full-term pregnancy\n* Cephalic presentation\n* No contraindication to vaginal delivery\n\nExclusion Criteria:\n\n* Patients with rupture of membranes\n* Patients who do not require cervical ripening and proceed directly to the delivery room for induction with oxytocin\n* Patients for whom the use of a double-balloon catheter\u002FPGE2 is contraindicated\n* Twin pregnancies\n* Pregnancies with macrosomic fetuses where vaginal delivery is contraindicated\n* Patients with maternal or fetal pathologies that do not allow for vaginal delivery due to concerns about fetal or maternal distress",true,"FEMALE","18 Years","50 Years",{"count":22,"type":23},400,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this interventional study is to evaluate the effectiveness of membrane stripping in cervical ripening compared to double balloon catheter induction.\n\nThe study population consists of women undergoing labor induction.\n\nThe main questions it aims to answer are:\n\n1. Is membrane stripping as effective as double balloon catheter induction in cervical ripening?\n2. What is the influence of membrane stripping on the time required for cervical ripening, delivery duration, and maternal and fetal outcomes compared to balloon induction.",[29,30,31,32,33,34],"Labor, Induced","Cervical Ripening","Balloon Induction","Membrane Stripping","Pregnancy Related","Induction of Birth","RECRUITING","2026-04-10",{"date":38,"type":39},"2026-04-15","ACTUAL",{"date":41,"type":39},"2024-08-07",{"date":43,"type":23},"2027-12-31",{"name":45,"class":46},"Meir Medical Center","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":47},"100621110","pge2-followed-by-oxytocin-vs-oxytocin-in-term-prom-poxy-prom-100621110","NCT07366359","PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM)","Comparison of the Effectiveness of Labor Induction Using Dinoprostone Followed by Oxytocin Versus Oxytocin Alone in Term Pregnancies With Premature Rupture of Membranes and an Unfavorable Cervix - A Randomized Clinical Trial","POXY-PROM","Inclusion Criteria\n\n* Maternal age ≥ 18 years\n* Gestational age from 37 to 42 weeks, determined by last menstrual period or by a first- or second-trimester ultrasound\n* Live singleton fetus\n* Prelabor rupture of membranes (PROM) confirmed by at least one of the following:\n\n  * Amniotic fluid visibly draining from the cervical os during sterile speculum examination\n  * Pool of fluid in the posterior fornix\n* Cephalic presentation\n* Bishop score ≤ 6\n* No spontaneous uterine contractions\n* No contraindications for vaginal delivery\n\nExclusion Criteria:\n\n* Active labor\n* Previous uterine surgery (e.g., cesarean section)\n* Chorioamnionitis or non-reassuring fetal status\n* Major fetal anomalies\n* Contraindications to prostaglandin or vaginal delivery\n* Refusal to participate",{"count":57,"type":23},450,[26],"This study is being done to learn more about the best way to start labor for pregnant women whose water breaks at term before labor begins, a condition called term prelabor rupture of membranes (term PROM). When this happens and the cervix is not ready for labor, it is unclear which induction method works best and is safest for mother and baby.\n\nThe purpose of this study is to compare two common ways to induce labor in women with term PROM and an unfavorable cervix (Bishop score ≤ 6). One group will receive a vaginal dinoprostone insert (Propess) for 6 hours to soften the cervix, followed by oxytocin if labor does not start. The other group will receive immediate oxytocin through a vein.\n\nPregnant women aged 18 years or older with a single baby in head-down position at 37-42 weeks, whose water has broken and whose cervix is not yet favorable, may be able to join this study. All care will be provided at the National Hospital of Obstetrics and Gynecology in Hanoi, Vietnam, where both medicines are already used in routine practice.\n\nThe main outcome is how many women have a vaginal birth. The study will also look at how long it takes from induction to birth, complications for mothers and babies, and women's experiences of labor. The results may help doctors choose the safest and most effective way to induce labor for women with term PROM in the future.",[61,29,30],"Premature Rupture of Fetal Membranes",[61,63,64,65,30,66],"Labor Induction","Dinoprostone","Oxytocin","Vaginal Delivery","2026-02-18",{"date":69,"type":39},"2026-02-20",{"date":71,"type":39},"2026-02-10",{"date":73,"type":23},"2028-01",{"name":75,"class":46},"National Hospital of Obstetrics and Gynecology",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":82,"targetDuration":4,"studyType":24,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":47},"100611230","use-of-papaverine-to-shorten-the-second-stageduration-of-labor-in-pregnant-women-after-cervical-ripening-by-double-balloon-catheter-100611230","NCT07237880","Use of Papaverine to Shorten the Second Stage\u002FDuration of Labor in Pregnant Women After Cervical Ripening by Double-balloon Catheter","Inclusion Criteria:\n\n* Pregnant individuals aged 18-50 years\n* Singleton pregnancy\n* Gestational age 37-42 weeks\n* Admission for induction of labor with a double-balloon catheter\n* Planned vaginal delivery\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Previous cesarean delivery\n* Multiple gestation\n* Contraindication to vaginal delivery\n* Known hypersensitivity to papaverine\n* Known major fetal anomaly\n* Any condition requiring immediate delivery or precluding safe participation (as determined by the treating physician)",{"count":83,"type":23},184,[26],"This prospective, randomized, double-blind controlled trial aims to evaluate whether intravenous papaverine, administered immediately after the removal of a double-balloon catheter used for cervical ripening, can shorten the duration of labor in term pregnant women undergoing induction of labor. Papaverine is an antispasmodic medication that relaxes smooth muscle and is commonly used in obstetrics, although its effect on labor progression following mechanical cervical ripening has not been fully studied.\n\nEligible participants include nulliparous and multiparous women with a singleton pregnancy at 37-42 weeks, admitted for induction of labor with a double-balloon catheter. After catheter removal, participants will be randomized in a 1:1 ratio to receive either 80 mg intravenous papaverine or placebo (normal saline), administered by the midwife who is not involved in clinical decision-making. Clinical staff and participants will remain blinded to group allocation.\n\nThe primary outcomes are the time from drug administration to complete cervical dilation and the duration of the second stage of labor. Secondary outcomes include mode of delivery, maternal complications (such as perineal tears and postpartum hemorrhage), oxytocin augmentation duration and maximum dose, and neonatal outcomes.\n\nThis study seeks to determine whether papaverine can safely and effectively reduce labor duration following mechanical cervical ripening.",[29],"2026-01-04",{"date":89,"type":39},"2026-01-06",{"date":91,"type":39},"2025-04-22",{"date":93,"type":23},"2027-04-22",{"name":95,"class":96},"Hillel Yaffe Medical Center","OTHER_GOV",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":106,"conditions":107,"keywords":114,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":47},"100613914","maternal-informing-on-labor-induction-impact-on-childbirth-experience-100613914","NCT07272785","Maternal Informing on Labor Induction: Impact on Childbirth Experience","Inclusion Criteria:\n\n* Planned induction of labor at the antenatal ward or at the outpatient clinic\n* Adequate language skills (Finnish, Swedish, English)\n\nExclusion Criteria:\n\n* Induction at the delivery ward or at the obstetric emergency care clinic\n* Spontaneous onset of labor or a planned cesarean delivery\n* Age below 18 years at the time of recruitment",{"count":104,"type":23},50,"OBSERVATIONAL","The aim of this study is to explore the information provided to mothers about labor induction and its connection to their childbirth experience. In addition, the study examines how the use of social media may influence the birth experience among patients undergoing labor induction.",[29,108,109,110,111,112,113],"Labor, Obstetric","Pregnancy","Humans","Prospective Study","Prospective Study , Questionaires","Childbirth Experience",[115,116,109,117,118],"Childbirth experience","Induction of labor","Childbirth","Obstetrics","2025-12-16",{"date":121,"type":39},"2025-12-23",{"date":123,"type":39},"2025-12-08",{"date":125,"type":23},"2026-06",{"name":127,"class":96},"Turku University Hospital",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":24,"phases":137,"briefSummary":139,"conditions":140,"keywords":141,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":47},"100615085","phase-4-topical-anesthesia-during-catheter-insertion-for-cervical-ripening-tolerance-100615085","NCT07288021","Topical Anesthesia During Catheter Insertion for Cervical Ripening (TOLERANCE)","TOLERANCE","Inclusion Criteria:\n\n* Women scheduled for labor induction with balloon catheter.\n* 18 years of age or older.\n* Singleton pregnancy with a cephalic presentation.\n* ≥ 34 completed gestational weeks.\n* Does not participate in any other trial that might affect maternal or fetal\u002Fneonatal outcomes.\n* No contraindication for vaginal delivery\n\nExclusion Criteria:\n\n* Unable or unwilling to provide and sign informed consent forms.\n* Known sensitivity to EMLA or placebo substance.\n* Known vulvodynia or vaginismus - rendering vaginal examination not possible.\n* Any chronic pain syndrome",{"count":136,"type":23},200,[138],"PHASE4","The goal of this RCT is to learn if application of topical anesthetic cream to the perineum and posterior wall of vagina prior to balloon catheter insertion as part of labor induction will reduce pain levels experienced by pregnant individuals.\n\nAll participants are 18 or older, carrying a singleton in vertex position and in need of labor induction, are late-preterm or term (34 weeks gestation and onward) and without contraindication to vaginal delivery.\n\nInvestigators seek to compare pain levels and patient satisfaction between two groups:\n\nNulliparous patients, using EMLA or placebo (randomized, double blinded). Multiparous patients, EMLA or placebo.",[29],[142,143,144,145,146],"induction","balloon catheter","EMLA","Lidocaine\u002Fprilocaine","pain","2025-12-15",{"date":149,"type":39},"2025-12-17",{"date":151,"type":39},"2024-02-05",{"date":153,"type":23},"2026-07-01",{"name":155,"class":96},"Bnai Zion Medical Center",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":24,"phases":164,"briefSummary":166,"conditions":167,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":47},"100452899","phase-2-mifepristone-outpatient-labour-induction-100452899","NCT05177510","Mifepristone Outpatient Labour Induction","MOLI","Inclusion Criteria:\n\n1. Pregnant women between 36+5 and 41+5 weeks of gestation\n2. Singleton pregnancy\n3. Aged 18 years or older\n4. Unfavourable cervix (Bishop Score less than or equal to 6)\n5. The ability to understand and sign a written informed consent form, prior to participation in any screening procedures and must be willing to comply with all study requirements.\n\nExclusion Criteria:\n\n1. Breech presentation\n2. Early labour\n3. Contraindication to vaginal birth (placenta praevia, transverse lie, known or suspected cephalo-pelvic disproportion or other factor contraindicated to vaginal birth in the opinion of the investigator)\n4. Fetal growth restriction with oligohydramnios and\u002For abnormal Dopplers\n5. Presence of reduced fetal movements requiring urgent delivery, abnormal CTG or recent antepartum haemorrhage requiring immediate delivery\n6. Medical conditions:\n\n   i. sexually transmitted infections (active infections only) ii. bleeding disorders, on anticoagulants, steroid or aspirin therapy iii. prior uterine operations (Caesarean Section or myomectomy)\n7. Contra-indications to mifepristone including chronic adrenal, hepatic, renal failure\n8. Hypersensitivity to mifepristone or to any excipients, or malnutrition\n9. Severe asthma uncontrolled by therapy and inherited porphyria\n10. Any investigational drug with an expected interaction with mifepristone which has been administered within 30 days prior to the trial drug administration.",{"count":22,"type":23},[165],"PHASE2","The number of women having an induction of labour is increasing and is currently used in 33% of pregnancies for a range of medical reasons. The majority of women are admitted to hospital to have their labour induced, using methods which are protracted and associated with a poor birth experience, making them both costly and unpopular. Further, current methods of outpatient induction are unsuitable, unsafe and\u002For have a poor acceptability. The COVID-19 pandemic has driven a reduction in the number of face-to-face interactions taking place across all areas of medicine. Proving the efficacy and safety of Mifepristone would significantly reduce pre-labour admission rates and hospital length of stay for pregnant women, who are at particularly higher risk of COVID-19, and reduce delivery costs.",[29],"2025-09-03",{"date":170,"type":39},"2025-09-10",{"date":172,"type":39},"2023-08-25",{"date":174,"type":23},"2026-12-31",{"name":176,"class":46},"Chelsea and Westminster NHS Foundation Trust"]