[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"labour-analgesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:labour-analgesia":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,74,101,124],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100637678","prediction-of-local-anaesthetic-dosing-during-labour-epidural-analgesia-100637678",false,"NCT07614516","Prediction of Local Anaesthetic Dosing During Labour Epidural Analgesia","Prediction of Local Anaesthetic Dosing During Labour Epidural Analgesia: a Machine-learning Approach. The DIANA (Dosing Intrapartum ANAesthetics) Study.","DIANA","Inclusion Criteria:\n\n* Parturients receiving neuraxial analgesia for labour, as clinical practice\n\nExclusion Criteria:\n\n* Planned caesarean delivery","FEMALE","18 Years",{"count":20,"type":21},12500,"ESTIMATED","OBSERVATIONAL","Epidural analgesia is the gold standard for controlling labour pain. However, labour pain happens during neuraxial analgesia, due to anaesthetic, obstetric, maternal factors.\n\nThe investigators hypothesized that relevant variables, able to predict the local anaesthetic (LA) requirement during labour, can be identified at admission and each parturient may therefore be accordingly classified in \"low-requirement\" and \"high-requirement\". In this way, a predictive score may be developed, and the analgesic regimen may be matched to the individual patient, thus ensuring a timely and appropriate treatment of patients likely to require higher doses of LA, while minimizing potentially side effects of excessive treatment in the low-dose group.",[25],"Labour Analgesia",[27,28,29,30],"Machine Learning","Anesthesia, Obstetric","Anesthesia, Epidural","Anesthetics, Local","NOT_YET_RECRUITING","2026-05-22",{"date":34,"type":35},"2026-05-29","ACTUAL",{"date":37,"type":21},"2026-06-13",{"date":39,"type":21},"2026-10-31",{"name":41,"class":42},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":43},"100640737","a-research-comparing-efficacy-of-pieb-plus-pcea-vs-cei-plus-pcea-for-labour-analgesia-100640737","NCT07592364","A Research Comparing Efficacy of PIEB Plus PCEA vs CEI Plus PCEA for Labour Analgesia","A Randomized Controlled Trial Comparing Efficacy of Programmed Intermittent Epidural Bolus (PIEB) Plus Patient-Controlled Epidural Analgesia (PCEA) Versus Continuous Epidural Infusion (CEI) Plus Patient-Controlled Epidural Analgesia (PCEA) for Labour Analgesia","Inclusion Criteria:\n\n* All pregnant female \\> 36 weeks of gestation\n* Age 18 years old and above\n* ASA I and II\n* Consented for study\n\nExclusion Criteria:\n\n* Allergies to LA and opioids\n* Severe systemic and mental disease\n* Contraindication to regional analgesia\n* Hemodynamic instabilities\n* Systemic coagulopathies\n* Treatment with anticoagulants\n* Severe obstetric complications - eg. eclampsia, placenta previae\n* Patient refusal\n* Failed epidural insertion",{"count":52,"type":21},88,"INTERVENTIONAL",[55],"NA","During labour process, one of the most effective ways to manage pain is via epidural analgesia. It is commonly and widely use for all pregnant women underwent labour process. It provides good pain relief during labour process especially for contraction pain and pain during descending of baby during delivery.\n\nDuring epidural insertion, a small catheter (which is flexible and thin) will be inserted via epidural needle at the back. Using this epidural catheter, pain medication will be given to ease and help controlling the pain. This procedure is usually done after you have been admitted to labour room.\n\nIn this research, investigator will compare among two different method of epidural administration which are:\n\n\\- Programmed Intermittent Epidural Bolus with Patient-Controlled Epidural Analgesia (PIEB +\n\nPCEA):\n\n* This method will enable the medication to be served automatically within the set time through the epidural catheter and allows for participants to manage additional boluses of medication according to the participants pain level.\n\n  \\- Continuous Epidural Infusion with Patient-Controlled Epidural Analgesia (CEI + PCEA):\n* This method will deliver continuous infusion of medication and allows for participants to manage additional boluses of medication according to the participants pain level.\n\nInvestigator want to determine the best method between this two in order to have better pain control, less usage of medication and improving the satisfaction of patient. In participating this research, the participants will help us in understanding the best method to be use for the labour process in which eventually help other future patient who is in need.",[58,25],"Pregnant Women",[60,61,62,63,64,25],"Parturient","Pregnant","PIEB","PCEA","CEI","2026-05-13",{"date":67,"type":35},"2026-05-18",{"date":69,"type":21},"2026-07-01",{"date":71,"type":21},"2027-12-31",{"name":73,"class":42},"Aiman Bin Ab Adzim",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":53,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":43},"100632629","a-digital-educational-resource-to-improve-preparedness-for-shared-decision-making-about-labour-analgesia-100632629","NCT07516171","A Digital Educational Resource to Improve Preparedness for Shared Decision Making About Labour Analgesia","A Randomized Controlled Trial of a Digital Educational Resource to Improve Preparedness for Shared Decision Making About Labour Analgesia","PrepDM","Inclusion Criteria:\n\n* Pregnant individuals ≥ 18 years\n* Visiting OB clinic at Mount Sinai hospital during their 3rd trimester of pregnancy (≥ 28 weeks gestation)\n* Singleton gestation\n* Nulliparous\n* Considering labour epidural analgesia for childbirth\n\nExclusion Criteria:\n\n* Sensory, cognitive, or language barriers precluding participation\n* Limited English proficiency",true,"55 Years",{"count":85,"type":21},200,[55],"Labour analgesia decisions are often made under time pressure, while in pain, which may lead patients to feel unprepared or uninformed. Shared decision-making (SDM) enhances patient satisfaction, promotes alignment with personal values, and improves trust in clinical care. Digital tools can support SDM by providing accessible, evidence-based information.\n\nThe Society for Obstetric Anesthesia and Perinatology (SOAP) is an international organization made up of doctors who specialize in managing pain and anesthesia during pregnancy. Their focus is the wellbeing and safety of mothers and their babies from early pregnancy through delivery and recovery. The Painless Push digital resource educates mothers about ways to manage pain during labour.\n\nThis trial aims to evaluate whether directing patients to access to the website https:\u002F\u002Fthepainlesspush.com\u002F improves preparedness for shared decision-making compared to the current care, which is access to the Mount Sinai Obstetric Anesthesia website.",[25],[90,91],"labour pain","education","2026-04-14",{"date":94,"type":35},"2026-04-17",{"date":96,"type":21},"2026-04",{"date":98,"type":21},"2026-12",{"name":100,"class":42},"Samuel Lunenfeld Research Institute, Mount Sinai Hospital",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":53,"phases":111,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":43},"100618477","phase-1-spinal-analgesia-in-labour-pain-100618477","NCT07332130","Spinal Analgesia in Labour Pain","Effect of Adding Dexmedetomidine to Bupivacain _fentanyl Mixture in Spinal Analgesia for Normal Labour","Inclusion Criteria:\n\nAge of patint is between 18 and 40 years. gestational age of fetus is more than 37 weeks. singleton viable fetus and cephalic presentation. spontaneous labor with cervix dilation more than 5cm.\n\nExclusion Criteria:\n\nDrug allergy. Blood Disease. Infection at site of injection. patient takes anticoagulants. patient has pre-eclampsia ,cardiac disease (NYHA III-IV) or diabetes mellitus type I prior to the pregnancy patients refuse","40 Years",{"count":110,"type":21},100,[112],"PHASE1","To evaluate the efficacy and safety of dexmedetomidine as an adjuvant to bupivacain and fentanyl in spinal Analgesia to decreases pain during normal labour",[25],"2025-12-31",{"date":117,"type":35},"2026-01-12",{"date":119,"type":21},"2025-12-24",{"date":121,"type":21},"2026-03-02",{"name":123,"class":42},"Minia University Hospital",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":131,"targetDuration":4,"studyType":53,"phases":133,"briefSummary":135,"conditions":136,"keywords":137,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":43},"100618153","phase-3-effect-of-epidural-needle-injection-on-catheter-placement-success-during-painless-labour-100618153","NCT07327918","Effect of Epidural Needle Injection on Catheter Placement Success During Painless Labour","Effect of Epidural Needle Injection on Catheter Placement Success During Painless Labour: A Prospective Randomized Study","Inclusion Criteria:\n\n* Female patients aged 18-40 years.\n* ASA physical status II or III.\n* Singleton pregnancy.\n* Gestational age ≥37 weeks.\n* Active labour with cervical dilatation ≥3 cm.\n* Cephalic presentation.\n* Requesting epidural analgesia for painless labour.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* • Refusal to participate or to sign informed consent.\n\n  * Age \\\u003C18 or \\>40 years.\n  * ASA status ≥IV.\n  * Allergy to local anesthetics or saline.\n  * Coagulopathy or platelet count \\\u003C100,000\u002Fmm³.\n  * Local infection at the insertion site.\n  * Severe spinal deformity (scoliosis, kyphosis).\n  * Multiple pregnancy.\n  * Non-cephalic presentation (breech, transverse).\n  * Antepartum hemorrhage or placenta previa.\n  * Severe preeclampsia or eclampsia.\n  * Signs of fetal distress.\n  * Previous lumbar spine surgery.\n  * Difficult epidural anatomy (on ultrasound or palpation).\n  * BMI \\>40 kg\u002Fm²",{"count":132,"type":21},216,[134],"PHASE3","Epidural analgesia is the gold standard for painless labour, but successful catheter placement can be technically challenging due to anatomical and physiological changes in pregnancy. Injecting saline or local anesthetic through the epidural needle before catheter insertion has been proposed to facilitate catheter advancement by dilating the epidural space. This study aimed to evaluate the effect of epidural needle injection on the success rate and ease of catheter placement during labour analgesia.",[25],[138],"Epidural Needle","2025-12-26",{"date":141,"type":35},"2026-01-08",{"date":143,"type":21},"2026-06-28",{"date":145,"type":21},"2027-02-15",{"name":147,"class":42},"Al-Azhar University"]