[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lack-of-keratinized-gingiva\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lack-of-keratinized-gingiva":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100626797","star-matrix-vs-autogenous-graft-for-gingival-augmentation-split-mouth-rct-100626797",false,"NCT07440303","Star Matrix vs Autogenous Graft for Gingival Augmentation: Split-Mouth RCT","The Clinical Efficacy of Star Matrix Versus Autogenous Gingival Graft in Augmenting Keratinized Tissue Around Teeth- A Split-mouth Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Adults 20 - 80 years old who need gingival augmentation on both sides of the lower jaw.\n* Able and willing to sign the consent form, follow study instructions and return for all visits\n* Generally healthy (no significant illnesses or medicines that could interfere with healing).\n* Demonstrates good daily oral hygiene (low plaque levels at baseline).\n\nExclusion Criteria:\n\n* Does not meet any of the inclusion points or is unlikely to follow the schedule\n* Previous gingival graft at the study site that failed\n* Needs a root-coverage (recession-repair) procedure instead of simple width augmentation\n* Active, untreated gum disease, cavities, infection, or chronic inflammation near the study teeth\n* Used cigarettes, e-cigarettes, or other nicotine products within 3 weeks\n* Insulin-dependent diabetes or hemoglobin A1c \\> 6.5 %\n* Cancer (other than minor skin cancers or in-situ cervical cancer) within the past 5 years\n* Currently pregnant or breastfeeding\n* Taking (or soon to begin) drugs that change bone turnover (e.g., bisphosphonates, steroids)\n* Diseases that disturb bone metabolism (except common osteoporosis)\n* Auto-immune disease or known allergy to porcine collagen or study materials\n* Active infection at the planned graft site\n* Current use of systemic blood thinners (anticoagulants or antiplatelet agents; e.g., warfarin, heparin\u002FLMWH, DOACs such as apixaban\u002Frivaroxaban\u002Fdabigatran\u002Fedoxaban, or P2Y12 inhibitors such as clopidogrel\u002Fprasugrel\u002Fticagrelor)",true,"ALL","20 Years","80 Years",{"count":21,"type":22},12,"ESTIMATED","INTERVENTIONAL",[25],"NA","This split-mouth randomized controlled clinical trial will test whether a ready-to-use collagen membrane (Star Matrix) can widen the protective band of gum tissue (keratinized gingiva) as effectively as the standard free gingival graft harvested from the palate.\n\nCentral question Can Star Matrix provide the same or better gain in keratinized tissue width-with less patient discomfort and chair-time-than an autogenous graft?\n\nPrimary objectives\n\nCompare the 6-month increase in keratinized tissue width between Star Matrix and autogenous graft sites.\n\nAssess patient-reported pain and morbidity associated with each treatment.\n\nSecondary objectives\n\nMeasure operative time, early healing scores, esthetic outcomes, and (optional) histologic quality of the regenerated tissue.\n\nMethods Twelve adults with ≤ 2 mm keratinized tissue on contralateral lower-jaw teeth will be enrolled. Each participant receives Star Matrix on one side and a conventional free gingival graft on the other. Follow-up visits at 2, 4, 8, 12 and 24 weeks include clinical measurements, standardized photographs, and a 7-day postoperative pain diary. An optional 2 mm punch biopsy at 6 months is analyzed microscopically.",[28,29],"Lack of Keratinized Gingiva","Mucogingival Deformity - Insufficient Keratinized Tissue",[31],"mucogingival deformity","RECRUITING","2026-02-23",{"date":35,"type":36},"2026-02-27","ACTUAL",{"date":38,"type":36},"2025-11-06",{"date":40,"type":22},"2026-10-01",{"name":42,"class":43},"Harvard Medical School (HMS and HSDM)","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":16,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":44},"100485693","the-effect-of-free-gingival-graft-on-root-closure-100485693","NCT05604391","The Effect of Free Gingival Graft on Root Closure","The Effect of Two Different Graft Positioning Techniques on Creeping Attachment in Free Gingival Graft Operations","Inclusion Criteria:\n\n1. 18-99 years old\n2. The patient does not have any systemic disease\n3. Presence of at least one tooth with gingival recession in the mandibular anterior region\n4. Excessive dentin sensitivity and impaired esthetics associated with recession\n5. Identification of the enamel-cementum boundary in the shrinkage region\n6. The tooth is alive and there are no irregularities, grooves, caries and restorations in the area to be treated.\n7. No periodontal surgical treatment in the relevant areas in the last 24 months\n8. Presence of adequate keratinized and attached gingiva in the donor area\n\nExclusion Criteria:\n\n1. Being outside the specified age range\n2. Any contraindication for systematic periodontal surgery\n3. Failure to define the enamel-cementum boundary in the withdrawal region\n4. Presence of caries, restoration, root concavity in the area to be treated\n5. Patients who smoke more than 10 cigarettes per day\n6. Patients who use drugs that suppress the immune system or impair recovery\n7. Patients using drugs that impair bleeding\n8. Insufficient keratinized and attached gingiva in the donor area","18 Years","99 Years",{"count":55,"type":22},40,[25],"Free gingival graft is a mucogingival surgical technique applied to increase keratinized gingival width and reduce gingival recession. Free gingival graft is one of the most widely used approaches in root closure treatments and in increasing the height of the keratinized gingiva. Evaluation of the effect of the amount of creeping attachment on the root surface caused by the free gingival grafts placed coronally and apical to the mucogingival line on the gingival recession in the mandibular anterior region with keratinized gingival deficiency with gingival recession. Forty patients with gingival recession and insufficient keratinized gingival height will be randomly divided into 2 main groups as free gingival grafts to be placed coronal and apical to the gingival recession.",[59,28],"Gingival Recession",[61,62,63,64],"free gingival grafts","creeping attachment","root closure","gingival recession","2025-03-06",{"date":67,"type":36},"2025-03-10",{"date":69,"type":36},"2022-06-01",{"date":71,"type":22},"2026-03-15",{"name":73,"class":43},"Berceste Guler"]