[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lactate-blood-increase\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lactate-blood-increase":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,91],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100643185","electric-cardiometry-guided-standard-versus-restricted-fluid-therapy-in-robotic-prostaectomy-100643185",false,"NCT07626151","Electric Cardiometry-Guided Standard Versus Restricted Fluid Therapy In Robotic Prostaectomy","Effect Of Standard Versus Restricted Fluid Therapy Guided By Electric Cardiometry On Tissue Perfuison In Robotic Prostaectomy: A Randomized Controlled Study","Inclusion Criteria:\n\n* Male patient undergoing robotic assisted prostatectomy\n* ASA I-III\n\nExclusion Criteria:\n\n* ASA score more than III\n* BMI more than 40\n* Severe renal disease (GFR between 15 and 29)\n* Previous renal surgery.\n* Decompensated cardiac disease (NYHA class 3 or 4)","MALE","40 Years","80 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","Fluid therapy during surgery is an important factor that is related to long term mortality and morbidity and it's directly related to tissue perfusion as well. The main target in any surgery is what is the optimum fluid therapy to maintain the tissue perfusion and the precise balance between hazardous effects of hypervolemia that may cause delayed wound healing due to surgical anastomosis disruption or being hypovolemic that may cause tissue ischemia as acute kidney injury.\n\nFluid management guidance changed from static methods like central venous pressure into dynamic methods like pulse pressure variation (PPV) and stroke volume variation (SVV), which are now the most famous dynamic measures.\n\nElectrical cardiometry is a non-invasive cardiac output monitor which uses electrical cardiometry, now a commonly used device, to measure SVV which can be used to guide fluid therapy during surgeries.\n\nNow robotic assisted surgery is a common method in preforming many surgeries especially urological, since it's associated with numerous desirable outcomes including shorter post-operative stay and faster return to preoperative function.\n\nWith considerations related to severe Trendelenburg position and increased intra-abdominal pressure due to pneumo-peritoneum, robotic assisted surgeries are associated with many challenges in anesthesia especially the fluid therapy.\n\nFluid therapy in robotic surgeries is an area with growing research focus that need further exploration while there are established guidelines for fluid management in traditional surgeries, the optimal protocols for robotic surgeries are less well defined, needing more research.\n\nWe aim at this study to investigate the impact of liberal versus restricted fluid intake on the tissue perfusion reflected by serum lactate \\& creatinine clearance, while guiding therapy through electrical cardiometry, to reach optimum fluid protocol in prostatic robotic surgeries.",[27,28,29,30],"Prostate Cancer","Surgery","Fluid Overload","Lactate Blood Increase",[32,33,34,35,36,37,38],"Robotic","Prostatectomy","Sugery","Anesthesia","Fluid","Electric Cardiometry","Tissue Perfusion","RECRUITING","2026-06-05",{"date":42,"type":43},"2026-06-08","ACTUAL",{"date":40,"type":43},{"date":46,"type":21},"2026-12",{"name":48,"class":49},"Nazmy Edward Seif","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":73,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":50},"100623641","submental-tissue-oxygenation-and-arterial-lactate-in-major-surgery-100623641","NCT07399275","Submental Tissue Oxygenation and Arterial Lactate in Major Surgery","Relationship Between Submental Tissue Oxygenation, Microvascular Reactivity, and Arterial Lactate During Major Surgical Procedures","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Scheduled for major surgical procedures under general anesthesia\n* Major surgery defined as procedures associated with a risk of significant blood loss and\u002For impaired tissue perfusion, requiring invasive arterial blood pressure monitoring and hourly arterial blood gas analysis\n* Planned intraoperative arterial catheter placement as part of routine clinical care\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Refusal or inability to provide informed consent\n* Absence of invasive arterial blood pressure monitoring\n* Known pregnancy\n* Severe peripheral vascular disease affecting upper extremities\n* Anatomical abnormalities or skin conditions preventing placement of NIRS sensors on the submental or thenar regions\n* Emergency surgery requiring immediate intervention\n* Preoperative severe metabolic acidosis (arterial pH \\\u003C 7.20)",true,"ALL","18 Years",{"count":62,"type":21},150,"OBSERVATIONAL","During major surgical procedures performed under general anesthesia, changes in blood flow and oxygen delivery to tissues may occur due to blood loss, hemodynamic fluctuations, and anesthesia-related physiological effects. These changes can lead to impaired tissue perfusion, which is commonly reflected by increased arterial lactate levels. However, lactate measurements are intermittent and may not detect early perfusion abnormalities.\n\nThis prospective observational study aims to investigate the relationship between submental tissue oxygenation measured by near-infrared spectroscopy (NIRS), microvascular reactivity assessed by the vascular occlusion test, and arterial lactate levels during major surgery. Adult patients undergoing major abdominal, neurosurgical, or orthopedic procedures will be monitored intraoperatively using non-invasive NIRS techniques, while arterial blood gas analyses will be performed as part of routine clinical care.\n\nThe study does not involve any changes to standard anesthesia or surgical management. All treatments and clinical decisions will be made by the responsible care team according to routine practice. By evaluating non-invasive indicators of tissue oxygenation and microvascular function, this study aims to improve the understanding of early intraoperative tissue perfusion changes and their association with metabolic markers.",[66,67,68,69,70,71,30,72],"Microcirculatory Dysfunction","Tissue Hypoperfusion","Microcirculatory Status","Microvascular Circulation","Near Infrared Spectroscopy","Vascular Occlusion Test","Major Surgery",[74,75,76,77,78,79],"tissue hypoperfusion","microvascular circulation","Near infrared spectroscopy","vascular occlusion","lactate blood increase","Major surgery","NOT_YET_RECRUITING","2026-02-03",{"date":83,"type":43},"2026-02-10",{"date":85,"type":21},"2026-02-15",{"date":87,"type":21},"2027-02-15",{"name":89,"class":90},"Bursa Sevket Yilmaz Training and Research Hospital","OTHER_GOV",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":58,"sex":59,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":101,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":124},"100567251","the-lactate-project-investigating-the-impact-of-lactate-to-preserve-vital-organ-blood-supply-and-function-in-heart-and-brain-100567251","NCT06665763","The Lactate Project: Investigating the Impact of Lactate to Preserve Vital Organ Blood Supply and Function in Heart and Brain","Inclusion Criteria:\n\n1. Age 55-75 years\n2. Male or postmenopausal female\n3. BMI 20-35 kg\u002Fm2\n4. Signed informed consent form\n\nExclusion Criteria:\n\n1. Clinically significant heart, lung, kidney, kidney, liver, endocrine or malignant disease basedon information obtained during an initial screening visit as well as blood samples and an ECG.\n2. Blood donation within the last 3 months\n3. Smoking\n4. Alcohol- or substance abuse\n5. Participation in other clinical trials involving ionized radiation within the last 6 months\n6. Claustrophobia","55 Years","75 Years",{"count":100,"type":21},8,[24],"The aim of the proposed study is to investigate the effect of increased plasma lactate concentrations on the heart and brain's metabolism of other energy sources, primarily glucose in the brain and glucose and FFA in the heart.\n\nThe investigator hypothesize that:\n\n* An acute increase in lactate plasma concentration will decrease cerebral glucose uptake and increase cerebral blood flow\n* An acute increase in lactate plasma concentration will decrease palmitate and glucose uptake in the myocardium, and increase myocardial perfusion",[104,30],"Healthy",[106,107,108,109,110,111,112,113,114],"Human metabolism","Substrate utilization","Cerebral blod flow","Cardiac metabolism","Cerebral metabolism","Cardiac perfusion","Glucose metabolism","Lipid metabolism","Lactate utilization","2024-10-30",{"date":117,"type":43},"2024-11-01",{"date":119,"type":21},"2025-02-01",{"date":121,"type":21},"2026-06-01",{"name":123,"class":49},"University of Aarhus",2]