[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"language-delay\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:language-delay":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,51,82,114,147,184],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100528138","using-neuroimaging-and-behavioral-assessments-to-understand-late-talking-100528138",false,"NCT06156865","Using Neuroimaging and Behavioral Assessments to Understand Late Talking","Neuroimaging Reveals Treatment-related Changes in DLD: A Randomized Controlled Trial (Supplement)","Inclusion Criteria:\n\n* child and parent are monolingual\u002Fnative (primarily) English speakers\n* child is enrolled at one of the participating facilities\n* child is recruited via word of mouth, including social media\n* child is between 18 and 30 months of age\n* child does not have any contraindications to magnetic resonance imaging (i.e., intracranial metal implants, claustrophobia)\n* child does not have any uncorrected vision challenges\n\nExclusion Criteria:\n\n* Child does not meet criteria for LT or typical development\n* Standard magnetic resonance imaging exclusion criteria\n* Gestational age less than 37 weeks or greater than 42 weeks\n* Special education placement of child based on ability or behavior",true,"ALL","18 Months","30 Months",{"count":21,"type":22},45,"ESTIMATED","INTERVENTIONAL",[25],"NA","Late talkers (LT), representing 10-20% of children under 3, demonstrate hallmark syntax and vocabulary deficits similar to preschoolers with developmental language disorder. While effective and early interventions can mitigate the impact of late talking, not enough is known about its neural basis, yet is needed to inform the design of more individualized interventions. This proposed effort uses neuroimaging, along with behavioral methods, with the goal of better understanding the memory-language mechanisms that underlie learning and late talking, while also considering their association to treatment-related changes in LT.",[28,29,30],"Developmental Language Disorder","Language Delay","Language Development",[32,33,34,35,36,37],"children","late talking","typical development","assessment","intervention","neuroimaging","RECRUITING","2026-05-29",{"date":41,"type":42},"2026-06-02","ACTUAL",{"date":44,"type":42},"2024-01-19",{"date":46,"type":22},"2027-06-30",{"name":48,"class":49},"University of Toronto","OTHER",2,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100633641","prevent-language-delays-and-disorders-among-children-of-caregivers-with-substance-use-disorders-with-community-groups-and-individualized-services-100633641","NCT07529327","Prevent Language Delays and Disorders Among Children of Caregivers With Substance Use Disorders With Community Groups and Individualized Services","Evidence-based Intervention Enhancements to Reduce Language Delays and Disorders Among Children of Parents With Substance Use Disorders","Inclusion Criteria:\n\n1. Have a:\n\n   1. Self-reported lifetime history of substance use disorder treatment and\u002For\n   2. active substance use in the past year\n2. Be providing care for\u002Fparenting a child at least 10% of the time who is:\n\n   1. between the ages of 12-42 months\n   2. English\u002FSpanish bilingual or monolingual in English or Spanish\n   3. exposed to a third language once a week or less\n   4. not yet combining three or more words regularly\n   5. has less than 150 words in their expressive vocabulary\n3. Be able to provide consent for their target child to participate, or have a legal guardian provide consent for the child to participate\n4. Be able to speak and understand English and\u002For Spanish\n5. Be willing to attend groups once a week for six weeks at a participating site\u002Fgroup time\n6. If assigned additional services, willing to attend Zoom meetings\n7. Be 18 years of age or older\n\nExclusion Criteria:\n\n-Only one caregiver per focal child can participate in the research study. Caregivers whose participating child already has another caregiver enrolled in the research study will not be eligible to participate.","18 Years",{"count":60,"type":22},244,[25],"The goal of this clinical trial is to test ways to improve early language development among young children of parents with substance use disorder (SUD). Children of parents with SUD are at increased risk for language delays, and early supports may help prevent long-term learning challenges. This study will examine whether adding additional supports to group-based parenting intervention improves child language outcomes compared to the group intervention alone.",[29,64,65,30,66],"Substance Use Disorders","Language Disorders in Children","Prevention Intervention",[68,69,70,71],"Naturalistic communication intervention","Parenting","Group based intervention","Vocabulary Acquisition","2026-04-14",{"date":74,"type":42},"2026-04-20",{"date":76,"type":42},"2026-03-10",{"date":78,"type":22},"2029-11-30",{"name":80,"class":49},"University of Oregon",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":50},"100603122","talk-with-me-baby-leveraging-well-child-care-to-enhance-the-early-home-language-environment-100603122","NCT07132411","Talk With Me Baby: Leveraging Well-Child Care to Enhance the Early Home Language Environment","TWMB","Inclusion Criteria for Participants:\n\n* Child must be enrolled prior to attending their 2-month WCC visit, age 1 month (+\u002F- 30 days)\n* Full term (\\>=37 weeks gestation)\n* Singleton birth\n* Home language of English and\u002For Spanish\n* Child must receive WCC at a participating clinic\n\nExclusion Criteria for Participants:\n\n* Child with a severe congenital disorder that would affect neurodevelopmental outcomes, or hearing impairment that could affect participation\n* Parent does not live with or spend \\>=2 days\u002Fweek with the child\n* Family does not plan to continue services at the clinic\n\nInclusion Criteria for Clinics:\n\n* A primary care practice (family medicine or pediatric model) that delivers WCC for children from 0-36 months old\n* A minimum of 30% Medicaid\u002Funinsured visits\u002Fyear\n* A minimum of 300 unique 0 to 36-month-old patients\u002Fyear","1 Day","2 Years",{"count":92,"type":22},400,[25],"Language-rich interactions with a parent or caregiver can serve as a protective factor for young children, by supporting their language development and other positive long-term outcomes, but existing interventions have not had the necessary reach to families who need this information the most. This study utilizes the primary care setting as a low cost, scalable way to deliver language promotion intervention. Specifically, we will test the effectiveness and explore implementation of language promotion intervention (Talk With Me Baby) that embeds within anticipatory guidance during pediatric well-child care to boost early language development and optimize health, academic, and economic outcomes.",[96,29,97],"Child Language","Developmental Milestones",[99,100,101,102,103,104],"well-child care","primary care practices","home language environment","preventative intervention","language development","language promotion intervention","2026-03-20",{"date":107,"type":42},"2026-03-24",{"date":109,"type":42},"2026-02-05",{"date":111,"type":22},"2029-06",{"name":113,"class":49},"University of Kansas Medical Center",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":16,"sex":17,"minAge":121,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":23,"phases":125,"briefSummary":126,"conditions":127,"keywords":131,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":81},"100505449","combined-oral-motor-stimulation-and-language-on-preterm-infant-feeding-100505449","NCT05861531","Combined Oral Motor Stimulation and Language on Preterm Infant Feeding","The Combined Association of an Oral Motor Stimulation and Language Intervention on Preterm Infant Feeding","Inclusion Criteria:\n\n* 23-30 weeks\n* English and Spanish speaking\n\nExclusion Criteria:\n\n* Major congenital anomalies\n* Surgical necrotizing enterocolitis\n* Non-English and Non-Spanish speaking","23 Weeks","30 Weeks",{"count":124,"type":22},124,[25],"This is a randomized controlled trial to study an oromotor stimulation in combination with a reading curriculum in the NICU among preterm infants using oral muscle exercises, Language Environment Analysis (LENA) recordings, linguistic feedback, and a language curriculum to improve the neonatal inpatient oral feeding and language outcomes for preterm infants.",[29,30,128,129,130],"Feeding; Difficult, Newborn","Mother-Infant Interaction","Maternal Behavior",[132,133,134,135,136,137],"Neonatal feeding","Neonatal language","Oromotor stimulation","Newborn reading","Parent infant interaction","LENA","2025-09-10",{"date":140,"type":42},"2025-09-17",{"date":142,"type":42},"2025-07-01",{"date":144,"type":22},"2030-07-01",{"name":146,"class":49},"Women and Infants Hospital of Rhode Island",{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":17,"minAge":155,"maxAge":156,"enrollmentInfo":157,"targetDuration":156,"studyType":159,"phases":4,"briefSummary":160,"conditions":161,"keywords":167,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":81},"100603447","speech-of-kids-after-neonatal-encephalopathy-100603447","NCT07136636","Speech of Kids After Neonatal Encephalopathy","Investigating the Prognostic Accuracy of Different Biomarkers for Detection of Developmental Language Disorder in Children With Neonatal Encephalopathy","SANE","Children born between 2017 and 2023 with moderate to severe HIE, treated with therapeutic hypothermia at Semmelweis University Children's Hospital.\n\nInclusion criteria\n\n1. Born at ≥ 35th week of gestation\n2. Attended follow-up examinations at two years of age\n3. Has parental informed consent\n\nExclusion criteria\n\n1. Hearing loss\n2. Multilingual language environment\n3. Congenital abnormalities\n4. Metabolic disease\n5. Sudden unexpected postnatal collapse\n6. Brain injury not caused by HIE\n7. Severe motor impairment defined as a score \\\u003C70 on the psychomotor development index (PDI) at 2 years of age","0 Years","7 Years",{"count":158,"type":22},93,"OBSERVATIONAL","The goal of this ambispective cohort study is to reveal the early indicators of delayed language development in children born with hypoxic-ischemic encephalopathy (HIE).\n\nWe will examine the prognostic accuracy of different biomarkers, with a special focus on the ADC values of the corpus callosum.\n\nThe main questions it aims to answer are:\n\n1. To what extent does hypoxic-ischemic encephalopathy (HIE) in infancy affect intellectual development (IQ), receptive and expressive language abilities at different levels of the language system, and memory capacities related to language development?\n2. What is the relationship between early biomarkers of brain injury-such as blood gas levels, lactate, aEEG, and MRI findings (Weeke scoring system, ADC values of the corpus callosum)-and long-term cognitive developmental outcomes?\n3. What is the incidence of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in this high-risk population of infants with HIE?\n4. Is there an association between the Weeke Total Score and long-term language developmental outcomes?\n5. Can restricted diffusion (ADC values) of the splenium of the corpus callosum serve as an early neuroradiological marker of developmental language disorder (DLD)?\n\nOur participants are children born between 2017 and 2023 with moderate to severe HIE, treated with therapeutic hypothermia at Semmelwies University Children's Hospital. During their first days of life, several neonatal measurements were taken (blood gas markers, aEEG etc.), and at day 4-5, they had an MRI scan of their brain. The MRI scans will be reanalyzed, using the Weeke MRI scoring system. These children underwent a neurodevelopmental follow-up at the age of 2 years and currently, they will have another follow-up at the age of 4-7 years.",[162,29,163,164,165,166],"HIE - Hypoxic - Ischemic Encephalopathy","Autism","ADHD - Attention Deficit Disorder With Hyperactivity","Specific Language Impairment","Intellectual Developmental Disorder",[162,168,169,170,171,172,173,174],"delayed language development","neurodevelopment","MRI","biomarker","corpus callosum diffusion restriction","IQ","newborn prediction tool","2025-08-14",{"date":177,"type":42},"2025-08-22",{"date":179,"type":42},"2025-04-01",{"date":181,"type":22},"2026-12",{"name":183,"class":49},"Semmelweis University",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":17,"minAge":191,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":23,"phases":195,"briefSummary":196,"conditions":197,"keywords":199,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":81},"100589132","pbfs-guided-aitbs-over-language-network-for-asd-child-100589132","NCT06950437","pBFS Guided aiTBS Over Language Network for ASD Child","Transcranial Magnetic Stimulation Guided by Personalized Brain Functional Sectors (pBFS) for Language Deficit Comorbid in Autism Spectrum Disorder Child: a Multi-center, Randomized, Sham-controlled Trial","Inclusion Criteria:\n\n1. Professionally diagnosed with ASD per DSM - 5 criteria.\n2. Aged 3 - 6.5 years, either gender.\n3. ADOS-2 results meet ASD standard cut - off.\n4. SCQ score: ≥15 (age ≥ 4 years) or ≥11 (age \\\u003C 4 years).\n5. Co-existing language disorder not explaining ASD symptoms. No organic speech organ lesions. CNBS-R2016 and CLAS-TP language-related equivalent age \\> 18 months; any CLAS-TP dimension score \\\u003C 6.\n6. Mandarin is the daily communication language.\n7. May have intellectual\u002Fglobal developmental delay not explaining ASD symptoms.\n8. Guardians volunteer, can cooperate in treatment and sign informed consent.\n\nExclusion Criteria:\n\n1. Identified genetic pathogenic factors; current\u002Fpast comorbid severe disorders (ADHD, Tourette's, etc.).\n2. Serious self-harm in the past year.\n3. Severe sensory\u002Fmotor disorders precluding cooperation.\n4. History of epileptic seizures.\n5. Serious organic diseases, especially brain related.\n6. Contraindications for MRI\u002FTMS (metal\u002Fimplants).\n7. Respiratory\u002Fcirculatory diseases with sedation risk.\n8. Illiterate guardians unable to handle informed consent\u002Fquestionnaires.\n9. Received neuromodulation in the past 3 months.\n10. Currently in other clinical trials.\n11. Deemed unfit by the researcher.","3 Years","6 Years",{"count":194,"type":22},150,[25],"The aim of this trial is to evaluate the efficacy and safety of precision neuromodulation in improving language ability in children with autism spectrum disorder (ASD) who also have language development delay. The neuromodulation will be delivered using the accelerated intermittent theta burst stimulation (aiTBS) protocol, targeting the language network in the left superior frontal gyrus (SFG), guided by personalized Brain Functional Sector (pBFS) technology.",[198,29],"Autism Spectrum Disorder",[200,201,202,203],"ASD","language delay","aiTBS","precision neuromodulation","2025-05-07",{"date":206,"type":42},"2025-05-11",{"date":208,"type":42},"2025-04-25",{"date":210,"type":22},"2027-06-01",{"name":212,"class":49},"Beijing Changping Tianhe Research Institute of Brain Science"]