[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"language-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:language-disorders":36},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,75,100,130,156,181],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":41,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":74},"100496255","cognitive-reserve-and-response-to-speech-language-intervention-in-bilingual-speakers-with-primary-progressive-aphasia-100496255",false,"NCT05741853","Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia","Cognitive Reserve and Linguistic Resilience in Bilingual Hispanics With Primary Progressive Aphasia","Inclusion Criteria:\n\n* Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)\n* Bilingual in Spanish and Catalan or bilingual in Spanish and English\n* Different proficiency levels across languages are expected, any prior experience in both languages is acceptable\n* Intervention study: Score of 15 or higher on the Mini-Mental State Examination\n* Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of 10 or higher on the Mini-Mental State Examination\n\nExclusion Criteria:\n\n* Other central nervous system or medical diagnosis that can cause symptoms\n* Other psychiatric diagnosis that can cause symptoms\n* Significant, uncorrected visual or hearing impairment that would interfere with participation\n* Prominent initial non-speech-language impairments (cognitive, behavioral, motoric)\n* Intervention Study: Score of less than 15 on the Mini-Mental State Examination\n* Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of less than 10 on the Mini-Mental State Examination",true,"ALL","40 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language (monolinguals), there is a significant need for investigating the effects of treatment that is optimized for bilingual speakers with PPA. This stage 2 efficacy clinical trial seeks to establish the effects of culturally and linguistically tailored speech-language interventions administered to bilingual individuals with PPA.\n\nThe overall aim of the intervention component of this study is to establish the relationships between the bilingual experience (e.g., how often each language is used, how \"strong\" each language is) and treatment response of bilinguals with PPA. Specifically, the investigators will evaluate the benefits of tailored speech-language intervention administered in both languages to bilingual individuals with PPA (60 individuals will be recruited). The investigators will conduct an assessment before treatment, after treatment and at two follow-ups (6 and 12-months post-treatment) in both languages. When possible, a structural scan of the brain (magnetic resonance image) will be collected before treatment in order to identify if brain regions implicated in bilingualism are associated with response to treatment. In addition to the intervention described herein, 30 bilingual individuals with PPA will be recruited to complete behavioral cognitive-linguistic testing and will not receive intervention. Results will provide important knowledge about the neural mechanisms of language re-learning and will address how specific characteristics of bilingualism influence cognitive reserve and linguistic resilience in PPA.",[27,28,29,30,31,32,33,34,35,36,37,38,39,40],"Primary Progressive Aphasia","Dementia","Dementia, Frontotemporal","Alzheimer Disease","Neurodegenerative Diseases","Frontotemporal Lobar Degeneration","Apraxia, Motor","Dysarthria","Communication Disorders","Language Disorders","Speech Disorders","Neurocognitive Disorders","Aphasia","Bilingual Aphasia",[42,43,44,27,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61],"Dementia, ADRD","Bilingualism","Multilingualism","Bilingual Primary Progressive Aphasia","Cognitive Reserve","Language Decline","Bilingual Language Decline","Speech-Language Therapy","Bilingual Speech-Language Therapy","Spanish speakers","Spanish-Catalan Bilinguals","Spanish-English Bilinguals","Hispanic","Catalán","Catalan","Spanish","Castellano","Speech Therapy","Latino","Cognition","RECRUITING","2026-06-08",{"date":65,"type":66},"2026-06-10","ACTUAL",{"date":68,"type":66},"2023-05-01",{"date":70,"type":21},"2027-11-30",{"name":72,"class":73},"Stephanie Grasso","OTHER",3,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":99},"100367112","phase-2-treatment-of-social-and-language-deficits-with-leucovorin-for-young-children-with-autism-100367112","NCT04060030","Treatment of Social and Language Deficits With Leucovorin for Young Children With Autism","Inclusion Criteria:\n\n1. 1\\. Autism Spectrum Disorder (diagnosed as Autistic Disorder on the ADOS-2 or the ADI-R).\n2. Between 2 years 6 months and 5 years 2 months of age at baseline\n3. Folate Receptor Alpha Autoantibody Positive status\n4. Language impairment (Ages and Stage Questionnaire between -1 and -3 SD for Language)\n5. English included in the languages in which the child is being raised\n6. Autism severity of moderate or higher (≥4) under the 7-item clinical global impression-severity scale. Moderate level of autism severity (4) is defined by the diagnosis of ASD with language impairment, so fulfilling #1 and #4 fulfills this requirement.\n7. Ability to maintain all ongoing complementary, dietary, traditional, and behavioral treatments constant for the study period\n8. Unchanged complementary, dietary, traditional, and behavioral treatments for two months prior to study entry\n9. Has at least 4 month old expressive language ability as assessed by the MSEL Expressive Language Scale (i.e., Parent answers \"yes\" to \" Voluntary babbling (such as 'bu, bu, bu\")\" Question #7 on the MSEL Expressive Language Scale.\n10. Ability to attend to social stimulus and tolerate imaging procedures, as determined at the discretion of the investigator\n\nExclusion Criteria:\n\n1. Known FRAA status by clinically validated test performed outside of research studies.\n2. Mineral or vitamin supplementation that exceeds the Tolerable Upper Daily Intake Levels set by the Institute of Medicine (See Table 6 below)\n3. Significant self-abusive or violent behavior or evidence of suicidal ideation, plan or behavior\n4. Severely affected children as defined by CGI-Severity Standard Score = 7 (Extremely Ill)\n5. Severe prematurity (\\\u003C34 weeks gestation) as determined by medical history\n6. Current uncontrolled gastroesophageal reflux\n7. Current or history of liver or kidney disease as determined by medical history and safety labs\n8. Genetic syndromes\n9. Congenital brain malformations\n10. Epilepsy\n11. Any medical condition that the PI determines could jeopardize the safety of the study subject or compromise the integrity of the data\n12. Significant negative reaction (i.e. fainting, vomiting, etc.) as a result of a previous blood draw.\n13. Failure to thrive or Body Mass Index \\\u003C 5%ile or \\\u003C5%ile for weight (male \\\u003C11.2kg; female \\\u003C10.8kg by CDC 2000 growth charts) at the time of the study.\n14. Concurrent treatment with drug that would significantly interact with l-leucovorin such as specific chemotherapy agents, antimalarial and immune suppressive agents and select antibiotics (See Table 7 below).\n15. Allergy or Sensitivity to ingredients in the investigational product or placebo\n16. Evaluation with the MSEL or BOSCC within 3 months of entering the study\n17. Planned evaluation with the MSEL or BOSCC during the study\n18. Exclusion Criteria for the MEG recording include:\n\n    1. Ferromagnetic implants, artificial joints, fixation hardware, dental work or shrapnel (additional screening will be completed to determine MRI eligibility)\n    2. Ferromagnetic products attached to the body (including hair extensions)\n    3. Head circumference greater than 60 cm\n    4. A weight greater than 407 lbs. (185 kg)","30 Months","60 Months",{"count":84,"type":21},80,[86],"PHASE2","The primary objective of this study is to evaluate the cognitive and behavioral effects of liquid leucovorin calcium on young children with autism spectrum disorder (ASD) and determine whether it improves social communication as well as the core and associated symptoms of ASD. The investigators will enroll 80 children across two sites, between the ages of 2.5 and 5 years, with confirmed ASD and known social and communication delays. Participation will last approximately 26 weeks, from screening visit to end of treatment.",[89,36],"Autism Spectrum Disorder","2026-04-22",{"date":92,"type":66},"2026-04-27",{"date":94,"type":66},"2020-10-08",{"date":96,"type":21},"2026-07-31",{"name":98,"class":73},"Southwest Autism Research & Resource Center",2,{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":17,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":111,"phases":4,"briefSummary":112,"conditions":113,"keywords":114,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":129},"100632814","development-and-validation-of-language-and-communication-assessment-scales-100632814","NCT07518576","Development and Validation of Language and Communication Assessment Scales","SCALE_COM","Inclusion Criteria:\n\nPatient admitted to the hospital for an intensive neurorehabilitation cycle or attending as an outpatient Diagnosis of language and communication disorders following a stroke in the right or left hemisphere Age \\> 18 years Ability to provide informed consent Native speaker of Italian (L1 Italian)\n\nExclusion Criteria:\n\n* Unstable clinical conditions that may interfere with participation in the study (e.g., active symptomatic infections, stupor, need for oxygen therapy)","18 Years","90 Years",{"count":110,"type":21},50,"OBSERVATIONAL","The aim of speech therapy for people with aphasia is to improve their ability to communicate in daily life. Traditional evaluations focus on linguistic tasks, but they do not fully address everyday communication skills, which are crucial for creating personalized treatment goals. The study suggests a multimodal approach to language assessment, stressing the importance of gestures in communication. It calls for the development of tools that evaluate communication in a wider context, including factors like motivation, attention, awareness, and alternative communication strategies. Additionally, there is a need for tools specifically designed to assess communicative gestures.",[36,39],[115,116,117,118,119],"language disorders","aphasia","conversation","gestures","assessment","2026-04-02",{"date":122,"type":66},"2026-04-08",{"date":124,"type":66},"2022-05-09",{"date":126,"type":21},"2026-12-31",{"name":128,"class":73},"IRCCS San Camillo, Venezia, Italy",1,{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":16,"sex":17,"minAge":137,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":129},"100518882","study-of-language-disorders-and-interactions-between-mnesic-capabilities-and-semantic-competencies-in-patients-with-psychosis-100518882","NCT06036316","Study of Language Disorders and Interactions Between Mnesic Capabilities and Semantic Competencies in Patients With Psychosis","TDLRipsy","Inclusion Criteria:\n\n* All Groups:\n\n  * Patient affiliated or entitled to a social security scheme\n  * Patient having received informed information on the study and having co-signed, with the investigator, a consent to participate in the study\n  * For minor participants, at least one of the parents or holders of parental authority having been informed of the study, having received the information note relating to it and not having objected to the participation of his or her child\n  * Native language: French\n* ARMS and FEP Patient Group:\n\n  * Age between 16 and 35 years old\n  * Present the criteria for EMRP or FEP as defined by the Comprehensive Assessment of At Risk Mental State (CAARMS) or present the criteria for Disorders of the course of thought to the items of the Schizophrenia Proneness Instrument (SPI-A)\n* Patients with schizophrenia group:\n\n  * Age between 16 and 55 years old\n  * Patient with diagnostic criteria for schizophrenia, as defined by DSM V (American Psychiatric Association, 2015)\n  * Present the criteria for Disorganization of Speech and Formal Thought Disorder as defined by the Thinking, Language and Communication (TLC) Rating Scale.\n* Healthy Volunteers Group:\n\n  * Age between 16 and 55 years old\n  * Parental authorization (of both parents) to participate in the study for minor patients\n\nExclusion Criteria:\n\n* All groups:\n\n  * Pregnant, parturient or nursing mother\n  * Person deprived of liberty by a judicial or administrative decision\n  * Person in a life-threatening emergency\n  * Adult subject to a legal protection measure (guardianship, curatorship, safeguard of justice)\n  * Adult person unable to express their consent and who is not the subject of a legal protection measure\n  * Impairment of the subject making it difficult, if not impossible, for them to participate in the trial or to understand the information given to them\n  * Abuse or dependence of any substance according to DSM V criteria excluding cannabis\n* Healthy Volunteers Group:\n\n  * Evolving psychiatric pathology (axis I of the DSM IV, measured at the MINI) excluding anxiety disorder\n  * Presence of developmental disorder of oral language or written language revealed on clinical examination.","16 Years","55 Years",{"count":140,"type":21},90,[24],"This research concerns the study of language disorders of patients present in the spectrum of psychosis. It is indeed accepted that psychotic disorders are associated with language difficulties, which are only poorly highlighted thanks to reusable tools in clinical practice. These language disorders impact communication, and concern many linguistic domains, thus covering phonology, lexicon, semantics, morphosyntax and pragmatics. It therefore seems relevant to characterize these language disorders and to assess to what extent they interact with the other symptoms of the pathology, in particular the course of the thought disorder and the neuropsychological symptoms. In addition, this study is particularly interested in the interactions between working memory capacities and those related to syntax. It is intended for different patients suffering from psychotic disorders of different intensities, treated in the Psychotherapeutic Center of Nancy. Patients suffering from at-risk mental state (ARMS), first episode of psychosis (FEP) or schizophrenia will benefit from a complete language assessment, evaluating each domain mentioned above, on the expressive and understanding sides. The results of the language assessment will be compared with those of a control group in the same tests. They will also be analyzed with regard to the neuropsychological and psychiatric elements noted in the patient's medical file, in order to highlight possible associations between language skills, neuropsychological and psychiatric symptoms in this patient population.",[144,145,146,36],"Psychosis","Schizophrenia","At-risk Mental State","2026-03-24",{"date":149,"type":66},"2026-03-27",{"date":151,"type":66},"2024-01-23",{"date":153,"type":21},"2026-06-01",{"name":155,"class":73},"Centre Psychothérapique de Nancy",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":17,"minAge":107,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":22,"phases":164,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":129},"100461025","neurophysiological-mechanisms-of-language-comprehension-100461025","NCT05283265","Neurophysiological Mechanisms of Language Comprehension","Inclusion Criteria:\n\n* Age 18 and older\n* Undergoing standard of care stereo Electro Encephalogram (sEEG) or Electro-Corticogram (ECoG) monitoring\n* Able to competently perform control trials of the task\n\nExclusion Criteria:\n\n* Age less than 18 years\n* Unable to competently perform control trials of the task",{"count":163,"type":21},153,[24],"First, in a recording-only self-paced reading experiment, patients with epilepsy undergoing intracranial monitoring for clinical purposes will read or listen to sentences presented to them one word at time while the investigators simultaneously record neural activity through intracranial electrodes that are implanted for clinical purposes (see subject populations). At the end of the sentence, the subjects have to indicate how they comprehended the sentence by selecting which of several pictures matches the sentence they just read. Behavioral measures that the investigators record and analyze are their response times to advance to each next word in the sentence, and which picture they chose for each sentence. These behavioral measures are compared against the neural activity simultaneously recorded as they are made.\n\nThen, in a later session, the same participants will participate in a task-related stimulation experiment. This follows the exact same design as the recording-only reading experiment, the only difference is that on some trials, at controlled moments during the sentence presentation intracranial electrical stimulation is delivered through adjacent intracranial electrode contacts. The investigators will examine the effect of this stimulation on the subjects comprehension of the sentences measured by their behavior, and on the simultaneously recorded neural activity.",[36],[168,169,170,171],"Neurophysiological","Language Comprehension","Direct brain stimulation","Self-paced reading","2026-03-09",{"date":174,"type":66},"2026-03-11",{"date":176,"type":66},"2022-04-08",{"date":178,"type":21},"2026-10-08",{"name":180,"class":73},"University of Alabama at Birmingham",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":16,"sex":17,"minAge":188,"maxAge":189,"enrollmentInfo":190,"targetDuration":4,"studyType":22,"phases":192,"briefSummary":193,"conditions":194,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":129},"100473341","enhancing-language-function-in-aphasia-100473341","NCT05443633","Enhancing Language Function in Aphasia","Enhancing Language Function in Aphasia Using Behavioral Language Intervention","Inclusion Criteria:\n\n1. Present with speech-language impairment (aphasia) caused by stroke or dementia\n2. A medical diagnosis of primary progressive aphasia (PPA) by a neurologist or physician\n3. Are native speakers of English\n4. Present with no contraindications for MRI\n5. Have adequate (normal or corrected to normal) vision and hearing\n\nExclusion Criteria:\n\n1. Individuals diagnosed with mood, anxiety, psychotic or substance abuse disorders.\n2. Individuals with highly magnetizable metallic implants, including certain dental work, may be excluded due to image quality in MRI.\n3. Individuals with other neurological disorders besides the ones of interest for the study (e.g., epilepsy, Multiple Sclerosis, Parkinson's Disease)\n4. Individuals with contraindications for MRI. This includes but is not limited to pacemakers, metallic cardiac pumps, valves, magnetic materials such as surgical clips, implanted electronic perfusion pumps, or any other condition that would preclude proximity to a strong magnetic field.\n5. Individuals suffering from clinically significant claustrophobia\n6. Severe systemic disease (e.g., renal failure)\n7. Poor overall health\n8. Individuals who are pregnant\n9. Individuals with a history of epileptic activity in the past 12 months\n10. Individuals with a personal or family history of epilepsy or other seizure disorders will not be included in the study.\n11. Individuals who have had a brain surgery in the past\n12. Individuals with implanted metallic skull plates or intracranial implants\n13. Individuals with skin lesions or skull damage\n14. Individuals who have a history of excessive use of alcohol or drugs\n15. Individuals with premorbid psychiatric disease affecting communication\n16. Individuals with severe non-linguistic cognitive disturbances impeding language therapy","21 Years","80 Years",{"count":191,"type":21},30,[24],"Aphasia is an acquired impairment of language, that commonly results from damage to language areas in the brain (typically the left side of the brain). This impairment is seen in many aspects of language, including understanding, speaking, reading and writing. It is estimated that about 2 million individuals are currently living with aphasia in the United States. Further, about 200,000 Americans acquire aphasia every year (National Aphasia Association, 2020). Aphasia poses significant impact on the affected individuals and their families. Behavioral treatments that target language deficits have been shown to enhance overall communication skills and life satisfaction among individuals with aphasia. Although there is evidence that suggests that treatment is efficacious for individuals with aphasia, the extent of improvement long-term coupled with the neural patterns among those individuals are largely unknown. The current study aims to investigate the efficacy of language-based treatment and its corresponding neural patterns.",[195,36,27,196],"Aphasia, Acquired","Stroke, Cerebrovascular","2024-12-04",{"date":199,"type":66},"2024-12-09",{"date":201,"type":66},"2022-10-30",{"date":203,"type":21},"2028-12-15",{"name":205,"class":73},"University of Arizona"]