[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"language\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:language":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,49,74,101,124,146,177,189,219],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100053795","language-processing-and-tms-100053795",false,"NCT05425615","Language Processing and TMS","Probing Language Processes Using Transcranial Magnetic Stimulation","Inclusion Criteria:\n\n* Diagnosed with left hemisphere stroke\n* Consent date \\>= 1 month after stroke onset\n* Right-handed\n* Fluent in English\n* 18 years of age or older\n\nExclusion Criteria:\n\n* Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing\n* Non-decisional per decisionality questionnaire or other clinical assessment\n* Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)\n* A chronic medical condition that is not treated or is unstable\n* Presence of\n\n  1. cardiac stimulators or pacemakers or intracardiac lines\n  2. neurostimulators\n  3. medication infusion device\n  4. any other implants near the scalp (e.g., cochlear implants) or in the eye\n  5. metal in the body\n* Pregnancy\n* History of skull fractures, or skin diseases\n* History of ongoing or unmanaged seizures or a family history of epilepsy\n* Presence of factors that potentially decrease seizure thresholds\n* On pro-convulsant medications\n* Untreated Sleep deprivation or insomnia\n* Ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)\n* History of dyslexia or other developmental learning disabilities",true,"ALL","18 Years","85 Years",{"count":21,"type":22},135,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.",[28,29,30],"Stroke","Aphasia","Language",[32,33,29,34,35],"TMS","Transcranial Magnetic Stimulation","Semantic processing","Phonological processing","RECRUITING","2026-07-09",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":40},"2024-06-05",{"date":44,"type":22},"2032-06",{"name":46,"class":47},"Medical College of Wisconsin","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":48},"100456361","computational-neuroscience-of-language-processing-in-the-human-brain-100456361","NCT05222594","Computational Neuroscience of Language Processing in the Human Brain","Inclusion Criteria:\n\n* clinical indications to proceed with intracranial monitoring involving the left cerebral hemisphere, as determined by a multidisciplinary epilepsy surgery team\n* the ability to comply with test directions and provide informed consent\n* between ages 18 - 85\n\nExclusion Criteria:\n\n* inability to understand or perform the task outlined in the protocol, or who are unwilling or unable to participate",{"count":56,"type":22},40,[25],"Language is a signature human cognitive skill, but the precise computations that support language understanding remain unknown. This study aims to combine high-quality human neural data obtained through intracranial recordings with advances in computational modeling of human cognition to shed light on the construction and understanding of speech.",[30,60],"Epilepsy",[62,63,64],"language","computational neuroscience","epilepsy","2026-05-05",{"date":67,"type":40},"2026-05-07",{"date":69,"type":40},"2021-04-02",{"date":71,"type":22},"2027-03-31",{"name":73,"class":47},"Massachusetts General Hospital",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":16,"sex":17,"minAge":81,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":48},"100614909","phonological-constraints-on-language-development-in-individuals-with-williams-syndrome-100614909","NCT07285720","Phonological Constraints on Language Development in Individuals With Williams Syndrome","SOUNDS","Inclusion Criteria:\n\n* For SW and SD: genetic diagnosis and aged between 6- and 17 years old.\n* For typical participants: any child, adolescent or young adult of the same developmental or chronological age (between 6 and 17 years of age)\n* adult group (between 20 and 60 years).\n\nExclusion Criteria:\n\n* Autistic Associated Disorders,\n* West syndrome","6 Years",{"count":83,"type":22},130,[25],"Williams syndrome (WS) is a neurodevelopmental disease characterized by mild to moderate intellectual disability and an extremely heterogeneous cognitive profile. Research has outlined two main features of WS: an atypical social behavior associated with surprising language abilities, and a hyperacusis. The purpose of this project is to investigate the relationships between both these abilities, and particularly the role of the hyperacusis on language abilities. The hyperacusis would be crucial in developing language skills: the apparent strength in the verbal domain could rely on Phonological Short Term Memory (PSTM) more in individuals with WS than in typically developing individuals. In addition, the investigators will compare individuals with WS to individuals with Down syndrome (DS): DS is often associated to strong limitations in the PSTM with poor language abilities. To this end, the investigators will use a highly innovative approach including physiological assessments (EEG-NIRS protocol) and questionnaires. The performance of people with WS will be compared to those of participants with DS and TD participants of same DA and cognitive assessments.",[87,30,88,89],"Williams Syndrome","Phonological Short-Term Memory","EEG-NIRS",[91,30,88,89],"Williams syndrome","2025-12-02",{"date":94,"type":40},"2025-12-16",{"date":96,"type":40},"2024-07-05",{"date":98,"type":22},"2026-07",{"name":100,"class":47},"Centre Hospitalier Universitaire, Amiens",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":17,"minAge":108,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":23,"phases":112,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":48},"100552287","neuroplasticity-biomarkers-in-aphasia-100552287","NCT06471127","Neuroplasticity Biomarkers in Aphasia","Genetic and MRI Biomarkers of Neuroplasticity Predict Aphasia Recovery and Phenotypes","Inclusion Criteria:\n\n1. Ages 40-90\n2. Right-handed (prior to stroke)\n3. Proficient English speakers\n4. History of a single ischemic stroke in the middle cerebral artery territory that is lateralized to the left or right (Aim 1) cerebral hemisphere.\n5. Presence of aphasia (Aims 2-3)\n6. Capacity to understand the nature of the study and provide informed consent\n7. Acute or subacute stroke at the time of Aim 1 enrollment; Stroke #12 months old (chronic) at the time of Aims 2-3 enrollment\n8. Medically stable\n\nExclusion Criteria:\n\n1. History of significant medical or neurological disorder (other than stroke)\n2. History of significant or poorly controlled psychiatric disorders\n3. Current abuse of alcohol or drugs, prescription or otherwise\n4. Clinically significant and uncorrected vision or hearing loss\n5. Anything other than standard of care stroke treatment such as Plavix, aspirin (81-300 mg daily), beta-blockers, diabetes medications or choles- terol-lowering agents, thrombolytics (e.g., tPA), anticoagulation agents such as Heparin, Warfarin\u002FCoumadin","40 Years","90 Years",{"count":111,"type":22},90,[25],"Patients with stroke frequently suffer from aphasia, a disorder of expressive and\u002For receptive language, that can lead to serious health consequences, including social isolation, depression, reduced quality of life, and increased caregiver burden. Aphasia recovery varies greatly between individuals, and likely relies upon the capacity for neuroplasticity, both at a systems level of reorganized brain networks and a molecular level of neuronal repair and plasticity. The proposed work will evaluate genetic and neural network biological markers of neuroplasticity associated with variability in aphasia, with a future goal to improve prognostics and identify therapeutic targets to reduce the long-term burdens of aphasia.",[29,30,28],"2025-10-21",{"date":117,"type":40},"2025-10-23",{"date":119,"type":40},"2025-03-17",{"date":121,"type":22},"2029-05-31",{"name":123,"class":47},"University of Wisconsin, Madison",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":23,"phases":134,"briefSummary":135,"conditions":136,"keywords":137,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":48},"100590965","post-stroke-aphasia-tms-100590965","NCT06974279","Post-Stroke Aphasia TMS","Precision Neuromodulation in Post-Stroke Aphasia Using TMS","TaMS","Inclusion Criteria:\n\n* Diagnosed with left hemisphere stroke\n* Consent date \\>= 1 month after stroke onset\n* Fluent in English\n* 18 years of age or older\n\nExclusion Criteria:\n\n* Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing\n* Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)\n* A chronic medical condition that is not treated or is unstable\n* The presence of cardiac stimulators or pacemakers or intracardiac lines, neurostimulators, medication infusion device, any other implants near the scalp (e.g., cochlear implants) or in the eye, metal in the body (e.g., splinters, fragments, clips)\n* Pregnancy\n* History of skull fractures, or skin diseases\n* History of ongoing or unmanaged seizures\n* Presence of factors that potentially decrease seizure thresholds: on pro-convulsant medications, untreated sleep deprivation or insomnia, ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)\n* History of dyslexia or other developmental learning disabilities",{"count":133,"type":22},50,[25],"The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia (SWA).",[29,28,30],[29,28,30,32],"2025-09-15",{"date":140,"type":40},"2025-09-19",{"date":142,"type":40},"2025-09-01",{"date":144,"type":22},"2036-12-31",{"name":46,"class":47},{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":16,"sex":17,"minAge":154,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":23,"phases":158,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":176},"100552914","talk-with-me-baby-to-enhance-the-early-home-language-environment-100552914","NCT06479278","Talk With Me Baby to Enhance the Early Home Language Environment","Talk With Me Baby: Leveraging Well-Child Care to Enhance the Early Home Language Environment for Rural and Underserved Children","TWMB","Inclusion Criteria:\n\nFor this study, each child-caregiver dyad will consist of:\n\n1. A caregiver who will receive TWMB during routine WCC visits for their child at participating clinics, and\n2. The child of the above caregiver for whom the WCC visits are conducted.\n\nA potential caregiver participant must meet all the following inclusion criteria to enroll in the study:\n\n1. Be the age of majority, or older, as defined by the state of residency.\n2. Able to complete study measures in English.\n3. Have the legal authority to consent to participate for themselves and to consent on behalf of their child.\n\nTo proceed to the follow-up portion of the study the caregiver (dyad) must have a LENA baseline assessment score that is ≤ 75th percentile compared to a child's age-referenced normative data.\n\nA potential child participant must meet all the following inclusion criteria to be enrolled in the study:\n\n1. Receive WCC at a participating clinic from a participating provider.\n2. Be zero to nine months (+ 0-30 days) old at enrollment.\n3. Was born at full term (\\> 37 weeks gestation).\n4. Was born in a singleton birth (i.e., was the only child delivered during the birth).","0 Months","9 Months",{"count":157,"type":22},66,[25],"The goal of this clinical trial is to learn if the Talk With Me Baby (TWMB) program improves the home-language environment for at-risk families with children ages two to six months when primary care providers deliver the program during well-child checkups. The main question it aims to answer is:\n\nWill the TWMB program increase the time a caregiver talks to their infant?\n\nParticipants will:\n\n1. Come to at least four well-child checkups\n2. Receive the TWMB program from the provider during the checkups\n3. Record their conversations with their infant before they receive the program and after they receive the program four times.",[161,162,163,164,165,30],"Language Development","Speech","Infant Development","Infant Behavior","Language, Child","2025-08-27",{"date":168,"type":40},"2025-08-29",{"date":170,"type":40},"2025-02-03",{"date":172,"type":22},"2026-08-31",{"name":174,"class":175},"IDeA States Pediatric Clinical Trials Network","NETWORK",2,{"id":178,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":179,"targetDuration":4,"studyType":23,"phases":180,"briefSummary":26,"conditions":181,"keywords":182,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":187,"leadSponsor":188,"locationsCount":48},"100471956",{"count":21,"type":22},[25],[28,29,30],[32,33,29,34,35],"2025-05-08",{"date":185,"type":40},"2025-05-11",{"date":42,"type":40},{"date":44,"type":22},{"name":46,"class":47},{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":193,"acronym":194,"eligibilityCriteria":195,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":196,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":198,"conditions":199,"keywords":204,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":48},"100569956","options-for-lowering-the-threshold-to-brussels-out-of-hours-primary-care-services-for-dutch-speaking-citizens-100569956","NCT06700980","Options for Lowering the Threshold to Brussels Out-of-hours Primary Care Services for Dutch Speaking Citizens","BruWNed","Inclusion Criteria:\n\n* Patients: adult, living in Brussels, Dutch-speaking\n* GPs: adult, working in Brussels, Dutch- and\u002For French-speaking\n* Employees of professional organization-regulatory bodies: adult, Dutch-and\u002For French-speaking\n\nExclusion Criteria:\n\n* Subject is not capable of will\n* Subject cannot express themself in Dutch or French",{"count":56,"type":22},"OBSERVATIONAL","The purpose of this qualitative study is to find out which technological translation tools can be used to improve Dutch-speaking care in all Brussels out-of-hours primary care services.",[200,30,201,202,203],"Communication Barriers","Primary Health Care","After-hours Care","Health Services Accessibility",[205,206,207,208,209],"Language barrier","translation","healthcare","technological tool","Official language minority","2024-12-23",{"date":212,"type":40},"2024-12-27",{"date":214,"type":40},"2024-12-10",{"date":216,"type":22},"2026-12",{"name":218,"class":47},"Universitair Ziekenhuis Brussel",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":225,"eligibilityCriteria":226,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":227,"enrollmentInfo":228,"targetDuration":4,"studyType":23,"phases":229,"briefSummary":230,"conditions":231,"keywords":234,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":48},"100562862","timing-and-facilitation-effects-of-theta-burst-stimulation-in-the-reading-and-language-networks-100562862","NCT06608680","Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Networks","Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Systems","TAFE","Inclusion Criteria:\n\n* Subjects must have a minimum of low average intellectual functioning (\\>=80) on at least one subscale on the Wechsler Abbreviated Scale of Intelligence-2 (WASI-2; Wechsler, 2011) to be included.\n* Within a normal range of reading skills as \\>85 on the Test of Word Reading Efficiency - Second Edition (TOWRE-2; Torgesen et al., 2012) and the Woodcock-Johnson IV Tests of Achievement (WJ-IV; Schrank et al., 2014)\n* Individuals with a documented history of learning disability will not be included. This will be determined via demographics questionnaire.\n* Subjects must be between the ages of 18 and 30 to be included. This will be determined via demographics questionnaire.\n* Because reading is critically linked to language, only individuals who are native speakers of English will be included in the study. This will be determined via demographics questionnaire.\n* The reading network is typically localized to the left side of the brain. However, left-handed individuals may have different brain lateralization, introducing an important confound to the study. Therefore, only right-handed individuals will be included in the study. This will be determined via demographics questionnaire.\n* Individuals who have hearing deficits (\\>25dB at 500+ Hz), visual deficits (\\>20\u002F40), serious emotional problems, certain neurological conditions (e.g., uncontrolled seizure disorders) will not be included. This will be determined via CABI Screening Forms and Demographics Questionnaire.\n* Individuals with certain metals in their bodies or with certain health conditions will not be included. If an individual has braces on their teeth, a cardiac pacemaker; hearing aid; other metal in their body or eyes (which may include certain metallic-embedded tattoos), including but not limited to pins, screws, shrapnel, plates, dentures or other metal objects they will not be included. This will be determined via CABI Screening forms.\n* Individuals with MRI Screening and Contraindication Forms which do not pass MRI Tech review will not be included.\n* Individuals with TMS Screening Forms which do not pass TMS Tech review will not be included.","30 Years",{"count":133,"type":22},[25],"The purpose of this study is to understand how transcranial magnetic stimulation affects how quickly, easily, and accurately a person read. Transcranial magnetic stimulation is a technique that uses magnetic fields to briefly affect how well certain brain regions function. The investigators would like to better understand how long the effects of transcranial magnetic stimulation occur in the reading system and at what point the effect is strongest in this system. The main questions it aims to answer are:\n\n1. At what point after stimulation are the greatest effects on behavior seen\n2. How excitatory and inhibitory stimulation affect behavior\n\nResearchers will compare stimulation types against a sham condition to see effects on reading and language behavior.\n\nParticipants will be asked to\n\n* undergo reading, language, and cognitive testing\n* receive an MRI\n* receive TMS stimulation\n* perform language, reading, and motor tasks",[232,30,233],"Reading","Control Subjects",[235,32,236,232,30],"transcranial magnetic stimulation","MRI","2024-09-19",{"date":239,"type":40},"2024-09-23",{"date":241,"type":40},"2023-05-01",{"date":243,"type":22},"2028-12-31",{"name":245,"class":47},"Georgia State University"]