[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"laparoscopic-abdominal-surgeries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:laparoscopic-abdominal-surgeries":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,83,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100626336","phase-3-use-of-dexmedetomidine-to-improve-pain-control-and-recovery-after-laparocopic-assisted-bowel-surgery-in-adults-100626336",false,"NCT07434310","Use of Dexmedetomidine to Improve Pain Control and Recovery After Laparocopic-Assisted Bowel Surgery in Adults","Postoperative Dexmedetomidine (PODEX) for Enhanced Recovery in Bowel Surgery: A Double-Blinded, Randomized Controlled Trial","PODEX","Inclusion Criteria:\n\n1. Adults aged 18-70 years.\n2. Undergoing elective or semi-elective laparoscopic-assisted bowel surgery (e.g., bowel resection, colectomy, ileostomy reversal).\n3. ASA physical status I-III.\n\nExclusion Criteria:\n\n1. Known allergy or hypersensitivity to dexmedetomidine.\n2. Cardiac impairment defined as:\n\n   1. Moderate or severe systolic dysfunction\n   2. Moderate or severe valvulopathy (as per American Society of Echocardiography criteria)\n   3. Significant bradycardia (baseline heart rate \\\u003C 60) or\n   4. Heart block without a pacemaker.\n3. Active infection or sepsis at the time of surgery.\n4. Use of medications with significant interactions with dexmedetomidine (e.g., MAO inhibitors).\n5. Pregnant or breastfeeding individuals.\n6. Current opioid use (\\> 30 mg daily oral morphine equivalent) or history of opioid use disorder.\n7. Current clonidine use.\n8. Patients undergoing thoracic epidurals.\n9. Patients with liver impairment with a Child-Pugh class of B (moderate) or C (severe).","ALL","18 Years","70 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"PHASE3","This study is testing whether continuing a medication called dexmedetomidine after surgery can improve quality of recovery for adults undergoing laparoscopic-assisted bowel surgery.\n\nAfter bowel surgery, many patients experience significant pain and slow recovery. Pain is often treated with strong opioid medications, which can cause side effects such as nausea, vomiting, constipation, sedation, and delayed return of bowel function. Other pain control options, such as epidurals or nerve blocks, are not always suitable for laparoscopic bowel surgery and may have their own risks or limitations. As a result, there are few effective non-opioid options for managing pain in this patient group.\n\nDexmedetomidine is a medication that can reduce pain and the need for opioids while providing sedation without affecting breathing. It is commonly used during surgery, but it is not known whether continuing dexmedetomidine after surgery improves pain control and overall recovery in bowel surgery patients. This study aims to answer that question.\n\nThe PODEX study is a single-centre, randomized, double-blind, placebo-controlled trial. Adults aged 18 to 70 years who are having elective or semi-elective laparoscopic-assisted bowel surgery will be invited to take part. About 94 participants will be enrolled. After surgery, participants will be randomly assigned (by chance) to receive either a continuous dexmedetomidine infusion or a placebo (salt water) infusion for 48 hours. Neither the participants nor the study team will know which treatment a participant receives during the study. All participants will receive the same standard surgical care, anesthesia, and postoperative pain medications.\n\nThe main outcome of the study is quality of recovery, measured 48 hours after surgery using a short questionnaire (QoR-15) that asks about comfort, pain, physical well-being, and emotional state. Other outcomes include recovery scores at additional time points, pain levels, opioid use, nausea and vomiting, return of bowel function, length of hospital stay, and side effects such as low blood pressure or slow heart rate.\n\nThe results of this study may help determine whether postoperative dexmedetomidine is a safe and effective way to improve recovery and reduce opioid use after bowel surgery.",[28,29,30],"Bowel Diseases, Inflammatory","Bowel Surgery","Laparoscopic Abdominal Surgeries",[32,33,34,35,36,37,38,39,40,41],"bowel surgery","pain after surgery","quality of recovery","recovery after surgery","laparoscopic surgery","postoperative pain","bowel surgery pain","laparoscopy surgery pain","abdominal pain","laparoscopy","NOT_YET_RECRUITING","2026-06-19",{"date":45,"type":46},"2026-06-24","ACTUAL",{"date":48,"type":22},"2026-07-01",{"date":50,"type":22},"2027-12-01",{"name":52,"class":53},"Dr. Naveed Siddiqui","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":67,"conditions":68,"keywords":69,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":4},"100628063","effect-of-low-dose-pregabalin-retard-825-mg-versus-standard-dose-pregabalin-retard-165-mg-on-postoperative-pain-and-opioid-consumption-after-elective-laparoscopic-abdominal-surgery-100628063","NCT07456761","Effect of Low-dose Pregabalin Retard (82.5 mg) Versus Standard-dose Pregabalin Retard (165 mg) on Postoperative Pain and Opioid Consumption After Elective Laparoscopic Abdominal Surgery","Effect of Low-dose Pregabalin Retard (82.5 mg) Versus Standard-dose Pregabalin Retard (165 mg) on Postoperative Pain and Opioid Consumption After Elective Laparoscopic Abdominal Surgery: a Randomized, Double-blind, Controlled Trial","Inclusion Criteria:\n\n* Age 18-75 years\n* ASA physical status I-III\n* Scheduled for elective laparoscopic abdominal surgery under general anesthesia (e.g. laparoscopic cholecystectomy, appendectomy, diagnostic\u002Ftherapeutic laparoscopic procedures without expected conversion to open surgery)\n* Ability to understand the NRS pain scale and the study procedures\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Known allergy or intolerance to pregabalin, gabapentinoids, or study medications\n* Chronic opioid use (daily use \\>30 mg oral morphine equivalent for \\>2 weeks preoperatively)\n* Regular use of gabapentin or pregabalin within 30 days\n* Severe renal impairment (eGFR \\\u003C 30 mL\u002Fmin\u002F1.73 m²) or on dialysis\n* Severe hepatic impairment (Child-Pugh C)\n* Uncontrolled epilepsy or other major neurological disorder\n* Severe psychiatric disease, alcohol or substance abuse\n* Pregnancy or breastfeeding\n* Planned postoperative ICU admission for reasons other than routine overnight monitoring\n* Conversion to open abdominal surgery (these patients will be analyzed in sensitivity or excluded, predefined in analysis plan)","75 Years",{"count":64,"type":22},80,[66],"NA","The goal of this clinical trial is to detect whether pregabalin retard (82.5 mg or 165 mg) improves analgesia after elective laparoscopic abdominal surgery in adults. It will also evaluate the safety of both doses.\n\nThe main questions it aims to answer are:\n\nDoes the higher dose (165 mg) reduce the total amount of opioids needed in the first 24 hours after surgery compared to the lower dose (82.5 mg)? Do the pain scores differ between the two doses? Are there differences in side effects between the two doses?\n\nResearchers will compare two different doses of pregabalin retard to determine which provides better pain control with fewer side effects.\n\nParticipants will:\n\nTake one dose of pregabalin retard (82.5 mg or 165 mg) before surgery Receive standard anesthesia and multimodal pain treatment Have their pain levels and opioid use monitored for 24 hours after surgery Be assessed for side effects such as dizziness, nausea, or sedation",[30],[70,71,72,73],"Pregabalin","Pain scores","Total opioid consumption","Laparoscopic abdominal surgery","2026-04-01",{"date":76,"type":46},"2026-04-02",{"date":78,"type":22},"2026-04",{"date":80,"type":22},"2026-12",{"name":82,"class":53},"South Egypt Cancer Institute",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":17,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":95,"studyType":96,"phases":4,"briefSummary":97,"conditions":98,"keywords":103,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":54},"100611562","transversalis-fascia-plane-versus-transversus-abdominis-plane-block-for-postoperative-analgesia-in-children-100611562","NCT07242196","Transversalis Fascia Plane Versus Transversus Abdominis Plane Block for Postoperative Analgesia in Children","Comparison of the Analgesic Effects of Ultrasound-Guided Transversalis Fascia Plane Block and Transversus Abdominis Plane Block in Pediatric Laparoscopic Surgery","Inclusion Criteria:\n\n* Pediatric patients aged 6 months to 16 years\n* Classified as ASA physical status I or II\n* Scheduled to undergo laparoscopic surgery under general anesthesia\n\nExclusion Criteria:\n\n* Patients classified as ASA physical status III or IV\n* Known allergy or hypersensitivity to local anesthetic agents\n* Presence of bleeding diathesis or coagulation disorders\n* Infection at the injection site or local skin lesions preventing block application",true,"6 Months","16 Years",{"count":94,"type":22},36,"1 Day","OBSERVATIONAL","This prospective clinical study aims to compare the postoperative analgesic efficacy of the ultrasound-guided transversalis fascia plane block (TFPB) and the transversus abdominis plane (TAP) block in pediatric patients undergoing laparoscopic surgery. Effective and long-lasting postoperative analgesia is essential for patient and parental satisfaction in pediatric anesthesia. With recent advances in ultrasound technology, regional anesthesia techniques have become increasingly utilized in pediatric practice.\n\nIn the TAP block, local anesthetic is injected between the internal oblique and transversus abdominis muscles, providing analgesia typically between Torachal vertebra 10 (T10) and Lumbar vertebra (L1) dermatomes. The transversalis fascia plane block, developed as a modification of this approach, targets the proximal portions of the T12 and L1 nerves by depositing local anesthetic between the transversus abdominis muscle and the transversalis fascia, potentially offering wider sensory coverage.\n\nThis study compares both blocks in terms of postoperative pain scores, duration of analgesia, and requirement for rescue analgesics in children undergoing laparoscopic surgery. The results are expected to contribute to the optimization of regional anesthesia techniques and improve pain management strategies in pediatric surgical patients.",[99,100,101,102,30],"Postoperative Analgesia","Transversus Abdominis Plane (TAP) Block","Transversalis Fascia Plane Block","Pediatric Surgical Procedures",[104,105,106,107,108],"transversus abdominis plane block","transversalis fascia plane block","pediatrics","laparoscopic abdominal surgery","postoperative analgesia","RECRUITING","2026-03-09",{"date":112,"type":46},"2026-03-10",{"date":114,"type":46},"2025-12-18",{"date":116,"type":22},"2026-06-15",{"name":118,"class":53},"Sakarya University",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":23,"phases":128,"briefSummary":129,"conditions":130,"keywords":4,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":136,"leadSponsor":137,"locationsCount":54},"100613898","erector-spinae-plane-block-on-postoperative-analgesia-in-patients-undergoing-laparoscopic-abdominal-surgeries-100613898","NCT07272577","Erector Spinae Plane Block on Postoperative Analgesia in Patients Undergoing Laparoscopic Abdominal Surgeries","Efficacy of Erector Spinae Plane Block on Postoperative Analgesia in Patients Undergoing Laparoscopic Abdominal Surgeries","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n* Body mass index (BMI) between 20-30 kg\u002Fm2.\n* Patients undergoing laparoscopic abdominal surgeries under general anesthesia.\n\nExclusion Criteria:\n\n* Bleeding or coagulation disorders.\n* Having local sepsis, pre-existing.\n* Peripheral neuropathies.\n* Chronic pain conditions.\n* Having any contraindication to regional anesthesia administration.\n* Opioid dependency.\n* Hypertension.\n* Uncontrolled diabetes mellitus.",{"count":127,"type":22},50,[66],"This study aims to evaluate the efficacy of the erector spinae plane block (ESPB) on postoperative analgesia in patients undergoing laparoscopic abdominal surgeries.",[131,99,30],"Erector Spinae Plane Block","2025-12-10",{"date":134,"type":46},"2025-12-11",{"date":132,"type":46},{"date":74,"type":22},{"name":138,"class":53},"Assiut University"]