[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"laparoscopic-appendectomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:laparoscopic-appendectomy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,75,105,130],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100641734","pre-incisional-infiltration-with-ropivacaine-plus-diprospan-for-relieving-postoperative-pain-after-laparoscopic-surgery-100641734",false,"NCT07626463","Pre-incisional Infiltration With Ropivacaine Plus Diprospan for Relieving Postoperative Pain After Laparoscopic Surgery","The Efficacy and Safety of Pre-incisional Infiltration With Ropivacaine Plus Diprospan in Patients Undergoing Laparoscopic Surgery: a Multi-center Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Patients scheduled for elective Laparoscopic Surgery for laparoscopic cholecystectomy, appendectomy, or hernia repair under general anesthesia;\n2. Ages 18 to 64 years old;\n3. American Society of Anesthesiologists (ASA) physical status of I-III;\n4. Patients must be able to understand nature and potential personal; consequences of the clinical trial and cooperation with follow-up investigations;\n5. signing of the informed consent form.\n\nExclusion Criteria:\n\n1. History of allergies to experimental drugs such as opioids or steroids;\n2. Alcohol abuse; Long term use of opioid drugs (exceeding 2 weeks or 3 days per week for more than 1 month); Suspected use of sedatives and analgesics;\n3. Use analgesic drugs within 24 hours before surgery;\n4. Patients undergoing steroid therapy;\n5. Serious neurological disorders, severe liver and kidney dysfunction, heart failure, etc;\n6. Unable to use pain assessment scale;\n7. Pregnant or lactating patients.","ALL","18 Years","64 Years",{"count":20,"type":21},150,"ESTIMATED","INTERVENTIONAL",[24],"NA","Incisional infiltration is the simplest, safest, and most effective anesthesia method for preventing incision pain after laparoscopic surgery, but even using long-acting local anesthetics, the effectiveness of postoperative analgesia can only last for a relatively short period of time. Studies have shown that up to 80% of patients experience postoperative pain following laparoscopic surgery due to inflammation caused by surgical incisions and surrounding tissues, necessitating pharmacological relief. Inflammatory mediators released from the soft tissues around laparoscopic incisions not only significantly alters the chemical microenvironment at the peripheral terminals of nociceptors, directly inducing pain, but also sensitizes afferent fibers, contributing to peripheral sensitization.\n\nNumerous studies have shown that glucocorticoids not only can achieve anti-inflammatory and analgesic effects by inhibiting inflammatory cytokines and inflammatory responses but also can prolong the duration of action of local anesthetics. Preemptive incisional infiltration using local anesthetics with corticosteroids which have potent local anti-inflammatory properties may play a key role in preventing or reducing postoperative pain. The objective of this trial is to determine whether preemptive incisional infiltration with ropivacaine plus diprospan is superior to ropivacaine alone in relieving postoperative pain for adults undergoing laparoscopic surgery. The investigators also compare the effects of the two intervention measures on postoperative pain management, patient safety, and recovery quality.",[27,28,29,30,31],"Laparoscopic Surgery","Laparoscopic Appendectomy","Laparoscopic Cholecystectomy","Laparoscopic Hernia Repair Surgery","Infiltration Anesthesia","RECRUITING","2026-06-16",{"date":35,"type":36},"2026-06-17","ACTUAL",{"date":38,"type":21},"2026-05-30",{"date":40,"type":21},"2028-05-30",{"name":42,"class":43},"Beijing Tiantan Hospital","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100497733","phase-4-fast-track-therapeutic-model-in-acute-complicated-appendicitis-in-pediatrics-100497733","NCT05761080","Fast Track Therapeutic Model in Acute Complicated Appendicitis in Pediatrics","Evaluation of a Therapeutic Strategy to Shorten Hospital Stay in Complicated Pediatric Appendicitis: A Randomized, Parallel, Multicenter, Open-Label Clinical Trial","FTAA","Inclusion criteria:\n\n* Ages 2 to 17 years. Intraoperative diagnosis of complicated appendicitis. Laparoscopic appendectomy. Agreement to participate in the study with signed informed consent.\n\nExclusion criteria:\n\n* Peritonitis with sepsis criteria. Catarrhal or phlegmonous appendicitis. History of cystic fibrosis, Crohn's disease, or transplant that may interfere with the usual postoperative course of laparoscopic appendectomy.\n\nContraindication to the administration of amoxicillin-clavulanic acid. Refusal to participate in the study by parents\u002Flegal guardians.","2 Years","17 Years",{"count":56,"type":21},772,[58],"PHASE4","To evaluate whether a postoperative therapeutic strategy, Fast Track, aimed at shortening hospital stay in pediatric patients undergoing laparoscopic appendectomy for complicated acute appendicitis, yields outcomes that are not inferior to the standard therapeutic model in terms of the combined variable of adverse events within 30 days postoperatively (including postoperative abdominal abscess, peritonitis, surgical wound complications, reintervention, sepsis, or death).",[28,61,62],"Complicated Appendicitis","Periappendicular Abscess",[64],"Complicated appendicitis","2026-03-19",{"date":67,"type":36},"2026-03-20",{"date":69,"type":36},"2021-04-22",{"date":71,"type":21},"2027-12",{"name":73,"class":43},"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau",7,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100620650","comparing-n-acetylcysteine-nac-versus-alpha-lipoic-acid-ala-as-adjuncts-for-postoperative-pain-management-after-laparoscopic-appendectomy-100620650","NCT07360379","Comparing N-Acetylcysteine (NAC) Versus Alpha-Lipoic Acid (ALA) as Adjuncts for Postoperative Pain Management After Laparoscopic Appendectomy","Inclusion Criteria:\n\n* Age 18-65 years, either sex\n\n  * ASA physical status I-III\n  * Undergoing laparoscopic appendectomy\n  * Able to provide informed consent and take oral medications postoperatively\n\nExclusion Criteria:\n\n* Chronic opioid use or chronic pain disorder\n* Pregnancy or lactation\n* Hepatic or renal impairment\n* Known hypersensitivity to NAC or ALA\n* Complicated appendicitis requiring open surgery or ICU admission\n\nExclusion Criteria:\n\n\\-","65 Years",{"count":83,"type":21},180,[24],"Postoperative pain remains a major concern following laparoscopic appendectomy, despite advances in minimally invasive surgery and multimodal analgesia. Inadequate pain control delays recovery, prolongs hospital stay, and increases opioid consumption with associated adverse effects. Therefore, identifying safe adjunct therapies that enhance analgesia and reduce opioid requirements is an important clinical goal.\n\nOxidative stress and inflammation play a critical role in the development and maintenance of postoperative pain. Surgical trauma induces the generation of reactive oxygen species, which sensitize peripheral nociceptors and enhance central pain transmission.\n\nAntioxidants capable of modulating oxidative stress and inflammatory pathways may therefore offer analgesic benefits beyond conventional analgesics.\n\nN-Acetylcysteine (NAC), a glutathione precursor, has demonstrated anti-inflammatory and analgesic properties in both experimental and clinical settings. It reduces oxidative stress, improves microcirculation, and modulates nociceptive signaling.\n\nAlpha-Lipoic Acid (ALA) is another potent antioxidant that acts as a cofactor in mitochondrial metabolism and has proven efficacy in neuropathic pain conditions. However, its role in acute postoperative pain has not been fully investigated.\n\nTo our knowledge, no clinical trial has directly compared NAC and ALA in the perioperative setting, and their effects following laparoscopic appendectomy remain unstudied. This randomized controlled trial aims to evaluate the efficacy and safety of NAC and ALA as adjuncts to standard analgesia, with the goal of estimating their effect on postoperative opioid consumption and pain intensity. The results will provide preliminary data to guide larger definitive studies.\n\nAim of the study The aim of this study is to evaluate and compare the efficacy and safety of N-acetylcysteine (NAC) and alpha-lipoic acid (ALA) as adjuncts to standard postoperative analgesia in patients undergoing laparoscopic appendectomy. Specifically, the study seeks to determine their effects on postoperative pain intensity, opioid consumption, and recovery profile in the early postoperative period.",[28,87,88],"Pain Management","Anti Oxidative Stress",[90,91,92,93,94],"Postoperative pain","Laparoscopic appendectomy","N- acetyl cysteine","Alpha lipoic acid","pain management","NOT_YET_RECRUITING","2026-01-16",{"date":98,"type":36},"2026-01-22",{"date":100,"type":21},"2025-12-28",{"date":102,"type":21},"2026-05",{"name":104,"class":43},"Ain Shams University",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":126,"leadSponsor":128,"locationsCount":44},"100602917","comparison-between-metallic-clip-ligation-and-suture-ligation-of-appendicular-stump-in-laparoscopic-appendectomy-100602917","NCT07129746","Comparison Between Metallic Clip Ligation and Suture Ligation of Appendicular Stump in Laparoscopic Appendectomy","Comparison Between Metallic Clip Ligation and Suture Ligation of Appendicular Stump in Laparoscopic Appendectomy, a Randomized Control Trial","Inclusion Criteria:\n\n1. Both genders, within the age bracket of 15 years - 60 years.\n2. With a BMI within the range of 18 - 28 kg\u002Fm2.\n3. With a diagnosis made by a consultant surgeon and the grade of appendicitis upto 3.\n\nExclusion Criteria:\n\n1. Patients with long standing comorbidities including chronic liver disease, diabetes mellitus, chronic kidney disease and hemorrhagic disorders.\n2. Patients taking anticoagulants, carrier of active cases of Hepatitis B, C and\u002For HIV.\n3. Patients on immunosuppression therapy. Diameter of appendicular stump of more than 10mm, perforated appendix, laparoscopic appendectomy converted to open appendectomy pelvic appendicitis and sub-hepatic appendicitis.","15 Years","60 Years",{"count":115,"type":21},10,[24],"Laparoscopic appendectomy is the standard procedure for acute appendicitis. Among the various steps of the procedure one of the rate limiting step is the ligation of the appendicular stump which can be done using suture material, metallic clips and hem o loks. This study compares the effect the using metallic clips versus suture material in the ligation of appendicular stump in terms of length of surgery and associated intra-operative complications. The patients included will be within the age group of 15-60 years, with BMI of 18-28kg\u002Fm2, and with acute appendicitis of upto grade 3. The data will be analyzed using SPSS a p value of \\\u003C0.05 will be considered as statistically significant.",[28],[120,121],"Appendicitis","Laparoscopy","2025-08-15",{"date":124,"type":36},"2025-08-19",{"date":122,"type":21},{"date":127,"type":21},"2026-02-20",{"name":129,"class":43},"Jinnah Hospital",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":4},"100579619","use-of-bipolar-diathermy-vs-clips-in-laparoscopic-appendectomy-100579619","NCT06826651","Use of Bipolar Diathermy VS Clips in Laparoscopic Appendectomy","Thermal Sealing by Bipolar Diathermy Versus Clips Closure of Mesoappendix in Laparoscopic Appendectomy ..A Comparative Study","Inclusion Criteria:\n\n* All patients admitted to AUH with uncomplicated acute appendicitis or chronic appendicitis\n* Age group (18-70)\n\nExclusion Criteria:\n\n* patients with complex appendicitis (appendicular mass, abscess, etc).\n* patients who had the following conditions: cirrhosis with ascites, abdominal distention, and coagulation disorders, cardiac patients; shock upon arrival, a large ventral hernia, and inflammatory bowel disease","70 Years",{"count":139,"type":21},100,[24],"Acute Appendicitis is the most frequent acute pathological abdominal illness needing immediate surgery. The laparoscopic appendectomy (LA) has become more popular and is advised as the first course of treatment, particularly for female, obese, and elderly patients.LA can also give surgeons a greater field view and identification of other abdominal organs that can have different pathologies that could mimic the symptoms of acute appendicitis.The most crucial step in preventing major complications such postoperative bleeding, peritonitis, sepsis is sealing the mesoappendix. Due to this circumstance, surgeons are looking for alternative treatments for LA. The best technique for sealing mesoappendix should be affordable, practical, safe, and easy to apply technically. Extracorporeal sliding knots, intracorporeal ligations, endo-loops, nonabsorbable polymer clips (Hem-o-lock clips), hand-made loops, and Ligasure usage, and bipolar cautery division are some of the techniques utilized at LA to seal mesoappendix. According to studies, each of these techniques is secure and practicable.5 In this study, there is a comparative study between using Bipolar diathermy as a source of sealing and other mechanical closure techniques for mesoappendix To assess effect of energy source sealing of mesoappendix by using Bipolar diathermy in comparison to mechanical closure by clips as regard outcome and complications.",[28,143],"Bipolar Diathermy","2025-02-10",{"date":146,"type":36},"2025-02-14",{"date":148,"type":21},"2025-03-01",{"date":150,"type":21},"2028-04-01",{"name":152,"class":43},"Assiut University"]