[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"laparoscopic-cholecystectomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:laparoscopic-cholecystectomy":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,43,0,25,[9,52,76,102,132,151,177,197,228,250,275,301,328,355,379,408,432,464,485,511,540,566,596,631,657],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100611543","external-oblique-intercostal-block-eoicb-for-laparoscopic-cholecystectomy-100611543",false,"NCT07241949","External Oblique Intercostal Block (EOICB) for Laparoscopic Cholecystectomy","Paravertebral Block or External Oblique Intercostal Block? A Comparative Analysis of Pain and Opioid Consumption After Laparoscopic Cholecystectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n* ASA physical status I-III\n* Able to understand the study procedure and provide informed consent\n\nExclusion Criteria:\n\nPatient refusal or inability to provide informed consent\n\nAllergy or contraindication to local anesthetics, tramadol, or study medications\n\nCoagulopathy or current anticoagulant therapy\n\nLocal infection at the planned block injection site\n\nSevere hepatic or renal impairment\n\nChronic opioid use or opioid dependence\n\nNeurological or psychiatric disorders affecting pain perception or communication\n\nPregnancy or breastfeeding\n\nBody mass index (BMI) \\> 35 kg\u002Fm²\n\nConversion to open cholecystectomy during surgery","ALL","18 Years","65 Years",{"count":21,"type":22},147,"ESTIMATED","INTERVENTIONAL",[25],"NA","This single-center, prospective, randomized controlled trial aims to compare the effects of paravertebral block (PVB), external oblique intercostal (EOI) block, and intravenous patient-controlled analgesia (PCA) with tramadol on postoperative pain and opioid consumption in patients undergoing elective laparoscopic cholecystectomy. The primary endpoint is total tramadol consumption within 24 hours postoperatively. Secondary outcomes include pain scores, additional analgesic use, incidence of nausea\u002Fvomiting, mobilization time, and length of hospital stay.",[28,29,30,31,32],"Postoperative Pain","Laparoscopic Cholecystectomy","Paravertebral Block","External Oblique Intercostal Plane Block","Patient Controlled Analgesia",[34,35,36,37,38],"Cholecystectomy","Pain","Analgesia","Tramadol","Nerve Block","RECRUITING","2026-06-30",{"date":42,"type":43},"2026-07-02","ACTUAL",{"date":45,"type":43},"2025-12-01",{"date":47,"type":22},"2026-12-05",{"name":49,"class":50},"Cukurova University","OTHER",1,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100644563","mechanical-power-during-different-ventilation-modes-in-laparoscopic-surgery-100644563","NCT07670494","Mechanical Power During Different Ventilation Modes in Laparoscopic Surgery","Comparison of Mechanical Power in Pressure-Regulated Volume Control and Volume-Controlled Ventilation Modes During Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Patients undergoing elective laparoscopic cholecystectomy surgery.\n* Patients between 18 and 75 years of age.\n* American Society of Anesthesiologists (ASA) physical status I, II or III.\n* Body Mass Index (BMI) between 18.5 and 35 kg\u002Fm².\n* Voluntary written informed consent for participation.\n\nExclusion Criteria:\n\n* History of significant chronic obstructive pulmonary disease (COPD) or asthma.\n* Previous lung resection or major thoracic surgery.\n* Heavy smokers (more than 20 cigarettes per day).\n* Presence of spontaneous breathing effort during mechanical ventilation.\n* Conversion from laparoscopic surgery to open surgery during the procedure.\n* Emergency surgery cases.\n* Known pregnancy.",true,{"count":61,"type":22},80,[25],"This study investigates how different breathing machine (ventilator) settings affect the energy delivered to the lungs during surgery. Mechanical power is a measure of this energy, and high levels can sometimes lead to lung irritation. In clinical practice, a mode called Pressure-Regulated Volume Control (PRVC) is often used because it lowers the \"peak\" pressure in the airways, which is generally thought to be safer. However, doctors have noticed that even though the peak pressure goes down in PRVC mode, the total mechanical power displayed on the monitor might actually increase compared to the standard Volume-Controlled Ventilation (VCV) mode. In this study, patients undergoing gallbladder surgery will be monitored using both ventilation modes in a random order. The researchers will compare the machine-calculated mechanical power for both modes to see if the perceived benefit of lower peak pressure in PRVC actually results in lower overall energy transfer to the lungs.",[29,65,66],"Mechanical Ventilation","Ventilator-Induced Lung Injury","NOT_YET_RECRUITING","2026-06-26",{"date":40,"type":43},{"date":71,"type":22},"2026-07-01",{"date":73,"type":22},"2026-08-12",{"name":75,"class":50},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":97,"leadSponsor":99,"locationsCount":51},"100641919","erector-spinae-plane-block-and-low-flow-anaesthesia-in-laparoscopic-cholecystectomy-100641919","NCT07653490","Erector Spinae Plane Block and Low-Flow Anaesthesia in Laparoscopic Cholecystectomy","Evaluation of the Effects of Preoperative Erector Spinae Plane Block Combined With Low-Flow Anaesthesia on Postoperative Quality of Recovery and Opioid Consumption: A Prospective, Randomized, Controlled Study","Inclusion Criteria:\n\n* Patients aged 18-65 years\n* ASA physical status I-II\n* Body mass index (BMI) \\\u003C35 kg\u002Fm²\n* Scheduled for elective laparoscopic cholecystectomy\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Coagulopathy or bleeding disorders\n* Allergy to local anaesthetic agents\n* Infection at the block application site\n* Neurological or psychiatric disorders\n* Communication difficulties\n* Chronic opioid or analgesic use\n* Reoperation cases\n* Acute cholecystitis\n* Conversion to open surgery\n* Inadequate dermatomal block after ESPB\n* Severe intraoperative hemodynamic instability\n* Intraoperative blood loss ≥250 mL\n* Development of allergic reactions or major complications during follow-up",{"count":84,"type":22},72,[25],"This prospective randomized controlled study aims to evaluate the effects of preoperative ultrasound-guided erector spinae plane (ESP) block combined with low-flow anaesthesia on postoperative quality of recovery and opioid consumption in patients undergoing elective laparoscopic cholecystectomy. The study will compare postoperative recovery quality, pain scores, analgesic requirements, and perioperative outcomes between patients receiving ESP block with low-flow anaesthesia and those receiving standard anaesthetic management.",[28,29],[89,90,91,92,29],"Erector Spinae Plane Block","Low-Flow Anaesthesia","Opioid Consumption","Enhanced Recovery","2026-06-18",{"date":95,"type":43},"2026-06-23",{"date":93,"type":43},{"date":98,"type":22},"2027-06-18",{"name":100,"class":101},"Taksim Egitim ve Arastirma Hastanesi","OTHER_GOV",{"id":103,"slug":104,"hasResults":12,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":23,"phases":112,"briefSummary":113,"conditions":114,"keywords":118,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":51},"100641974","pre-incisional-infiltration-with-ropivacaine-plus-triamcinolone-for-relieving-postoperative-pain-after-laparoscopic-surgery-100641974","NCT07591233","Pre-incisional Infiltration With Ropivacaine Plus Triamcinolone for Relieving Postoperative Pain After Laparoscopic Surgery","The Efficacy and Safety of Pre-incisional Infiltration With Ropivacaine Plus Triamcinolone for Postoperative Pain in Patients Undergoing Laparoscopic Surgery: a Multi-center Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Patients scheduled for elective Laparoscopic Surgery for laparoscopic cholecystectomy, appendectomy, or hernia repair under general anesthesia;\n2. Ages 18 to 64 years old;\n3. American Society of Anesthesiologists (ASA) physical status of I-III;\n4. Patients must be able to understand nature and potential personal; consequences of the clinical trial and cooperation with follow-up investigations\n5. signing of the informed consent form.\n\nExclusion Criteria:\n\n1. History of allergies to experimental drugs such as opioids or steroids;\n2. Alcohol abuse; Long term use of opioid drugs (exceeding 2 weeks or 3 days per week for more than 1 month); Suspected use of sedatives and analgesics; Use analgesic drugs within 24 hours before surgery; Patients undergoing steroid therapy;\n3. Serious neurological disorders, severe liver and kidney dysfunction, heart failure, etc;\n4. Unable to use pain assessment scale;\n5. Pregnant or lactating patients.","64 Years",{"count":111,"type":22},150,[25],"Incisional infiltration is the simplest, safest, and most effective anesthesia method for preventing incision pain after laparoscopic surgery, but even using long-acting local anesthetics, the effectiveness of postoperative analgesia can only last for a relatively short period of time. Studies have shown that up to 80% of patients experience postoperative pain following laparoscopic surgery due to inflammation caused by surgical incisions and surrounding tissues, necessitating pharmacological relief. Inflammatory mediators released from the soft tissues around laparoscopic incisions not only significantly alters the chemical microenvironment at the peripheral terminals of nociceptors, directly inducing pain, but also sensitizes afferent fibers, contributing to peripheral sensitization. Preemptive incisional infiltration using local anesthetics with corticosteroids which have potent local anti-inflammatory properties may play a key role in preventing or reducing postoperative pain. The objective of this trial is to determine whether preemptive incisional infiltration with ropivacaine plus triamcinolone is superior to ropivacaine alone in relieving postoperative pain for adults undergoing laparoscopic surgery. We also compare the effects of the two intervention measures on postoperative pain management, patient safety, and recovery quality.",[115,29,116,117],"Laparoscopic Surgery","Appendectomy, Laparoscopic","Hernia Repair",[119,120,121,122],"Laparoscopic","Incisional infiltration","triamcinolone","postoperative pain","2026-06-16",{"date":125,"type":43},"2026-06-17",{"date":127,"type":43},"2026-06-01",{"date":129,"type":22},"2028-05-30",{"name":131,"class":50},"Beijing Tiantan Hospital",{"id":133,"slug":134,"hasResults":12,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":109,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":140,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":146,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":150,"locationsCount":51},"100641734","pre-incisional-infiltration-with-ropivacaine-plus-diprospan-for-relieving-postoperative-pain-after-laparoscopic-surgery-100641734","NCT07626463","Pre-incisional Infiltration With Ropivacaine Plus Diprospan for Relieving Postoperative Pain After Laparoscopic Surgery","The Efficacy and Safety of Pre-incisional Infiltration With Ropivacaine Plus Diprospan in Patients Undergoing Laparoscopic Surgery: a Multi-center Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Patients scheduled for elective Laparoscopic Surgery for laparoscopic cholecystectomy, appendectomy, or hernia repair under general anesthesia;\n2. Ages 18 to 64 years old;\n3. American Society of Anesthesiologists (ASA) physical status of I-III;\n4. Patients must be able to understand nature and potential personal; consequences of the clinical trial and cooperation with follow-up investigations;\n5. signing of the informed consent form.\n\nExclusion Criteria:\n\n1. History of allergies to experimental drugs such as opioids or steroids;\n2. Alcohol abuse; Long term use of opioid drugs (exceeding 2 weeks or 3 days per week for more than 1 month); Suspected use of sedatives and analgesics;\n3. Use analgesic drugs within 24 hours before surgery;\n4. Patients undergoing steroid therapy;\n5. Serious neurological disorders, severe liver and kidney dysfunction, heart failure, etc;\n6. Unable to use pain assessment scale;\n7. Pregnant or lactating patients.",{"count":111,"type":22},[25],"Incisional infiltration is the simplest, safest, and most effective anesthesia method for preventing incision pain after laparoscopic surgery, but even using long-acting local anesthetics, the effectiveness of postoperative analgesia can only last for a relatively short period of time. Studies have shown that up to 80% of patients experience postoperative pain following laparoscopic surgery due to inflammation caused by surgical incisions and surrounding tissues, necessitating pharmacological relief. Inflammatory mediators released from the soft tissues around laparoscopic incisions not only significantly alters the chemical microenvironment at the peripheral terminals of nociceptors, directly inducing pain, but also sensitizes afferent fibers, contributing to peripheral sensitization.\n\nNumerous studies have shown that glucocorticoids not only can achieve anti-inflammatory and analgesic effects by inhibiting inflammatory cytokines and inflammatory responses but also can prolong the duration of action of local anesthetics. Preemptive incisional infiltration using local anesthetics with corticosteroids which have potent local anti-inflammatory properties may play a key role in preventing or reducing postoperative pain. The objective of this trial is to determine whether preemptive incisional infiltration with ropivacaine plus diprospan is superior to ropivacaine alone in relieving postoperative pain for adults undergoing laparoscopic surgery. The investigators also compare the effects of the two intervention measures on postoperative pain management, patient safety, and recovery quality.",[115,143,29,144,145],"Laparoscopic Appendectomy","Laparoscopic Hernia Repair Surgery","Infiltration Anesthesia",{"date":125,"type":43},{"date":148,"type":22},"2026-05-30",{"date":129,"type":22},{"name":131,"class":50},{"id":152,"slug":153,"hasResults":12,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":158,"targetDuration":4,"studyType":23,"phases":160,"briefSummary":161,"conditions":162,"keywords":166,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":4},"100641947","intertransverse-process-block-versus-m-tapa-block-after-laparoscopic-cholecystectomy-100641947","NCT07589491","Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Cholecystectomy","Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 18-65 years\n* ASA physical status I-III\n* Scheduled for elective laparoscopic sleeve gastrectomy\n* Body mass index (BMI) 18-35 kg\u002Fm²\n* Ability to understand and use the patient-controlled analgesia (PCA) device\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate\n* Allergy to local anesthetics\n* Infection at the injection site\n* Coagulopathy or ongoing anticoagulant therapy\n* Chronic opioid use or opioid dependence\n* Severe hepatic or renal insufficiency\n* Pregnancy or breastfeeding\n* Cognitive impairment or inability to communicate pain scores\n* Body mass index (BMI) \\>35 kg\u002Fm²",{"count":159,"type":22},60,[25],"This randomized clinical trial aims to evaluate and compare the analgesic efficacy of the Intertransverse Process Block (ITPB) and the Modified Thoracoabdominal Nerve Block through Perichondrial Approach (M-TAPA) in patients undergoing laparoscopic cholecystectomy. The primary outcome is the Visual Analog Scale (VAS) score within the first 24 hours after surgery. Secondary outcomes include total opioid consumption, requirement for rescue analgesia, block- related complications and adverse effects (hematoma, pneumothorax, local anesthetic systemic complications, vascular puncture, and infection), patient satisfaction assessed using a Likert scale, quality of recovery assessed using the QoR-15 questionnaire, and incidence of postoperative nausea and vomiting.",[163,164,29,28,165],"Intertransverse Process Block","Mtapa Block","Regional Anaesthesia",[167,168],"M-TAPA","ITP","2026-06-15",{"date":123,"type":43},{"date":172,"type":22},"2026-11-15",{"date":174,"type":22},"2027-10-30",{"name":176,"class":50},"Antalya City Hospital",{"id":178,"slug":179,"hasResults":12,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":109,"enrollmentInfo":184,"targetDuration":4,"studyType":23,"phases":186,"briefSummary":187,"conditions":188,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":191,"startDateStruct":192,"completionDateStruct":193,"leadSponsor":195,"locationsCount":196},"100642731","the-efficacy-and-safety-of-loxoprofen-sodium-patch-in-relieving-postoperative-pain-after-laparoscopic-surgery-100642731","NCT07591207","The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Laparoscopic Surgery","The Efficacy and Safety of Incisional Preemptive Analgesia Using Loxoprofen Sodium Patch in Patients Undergoing Laparoscopic Surgery: a Multi-center Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Patients scheduled for elective Laparoscopic Surgery for laparoscopic cholecystectomy, appendectomy, or hernia repair under general anesthesia;\n2. Ages 18 to 64 years old\n3. American Society of Anesthesiologists (ASA) physical status of I-III\n4. Patients must be able to understand the nature and potential personal consequences of the clinical trial and cooperate with follow-up investigations\n5. signing of the informed consent form.\n\nExclusion Criteria:\n\n1. History of chronic pain syndrome of any cause and mental illness\n2. Excessive alcohol or drug abuse, chronic opioid use (more than 2 weeks or 3 days per week for more than 1 month), use of drugs with confirmed or suspected sedative or analgesic effects, or use of any painkiller within 24 h before surgery.\n3. History of hypertension (Grade 3, extremely high risk)\n4. Pregnancy or breastfeeding.\n5. Extreme body mass index (BMI) (\\\u003C 15 or \\> 35).\n6. Participation in another interventional trial that interferes with the intervention or outcome of this trial.\n7. Digestive system diseases (such as peptic ulcers, gastric bleeding).\n8. Patients with coronary artery disease.\n9. Patients with renal impairment (serum creatinine \\> 176 µmol\u002FL) and abnormal liver function(alanine aminotransferase (ALT) and\u002For aspartate aminotransferase (AST) \\> 2× the upper limit of normal (ULN) or total bilirubin (TBIL) ≥ 1.5×ULN).\n10. Subjects with coagulation dysfunction (prothrombin time or activated partial thromboplastin time is higher than the normal threshold) or patients who are taking oral anticoagulants for other medical reasons and have not stopped it before surgery, such as warfarin or new anticoagulants rivaroxaban or dabigatran.\n11. Patients with a history of allergy to anyone of the study drugs.",{"count":185,"type":22},134,[25],"Studies have shown that up to 80% of patients experience postoperative pain following laparoscopic surgery due to inflammation caused by surgical incisions and surrounding tissues, necessitating pharmacological relief. Inflammatory mediators released from the soft tissues around laparoscopic incisions not only significantly alters the chemical microenvironment at the peripheral terminals of nociceptors, directly inducing pain, but also sensitizes afferent fibers, contributing to peripheral sensitization.\n\nThe investigators conducted a multicenter, prospective, randomized controlled clinical study to explore the use of Loxoprofen Sodium Patch for preoperative local incision analgesia in laparoscopic surgery patients. The investigators aim to observe whether this method can effectively alleviate postoperative incision pain, reduce the dosage of postoperative analgesics and the side effects caused using postoperative analgesics, improve patient satisfaction, and provide new ideas for postoperative analgesia in laparoscopic surgery patients, promoting rapid recovery after laparoscopic surgery.",[189,190,29,116,117],"Loxoprofen Sodium Patch","Local Incision",{"date":123,"type":43},{"date":127,"type":43},{"date":194,"type":22},"2028-05-31",{"name":131,"class":50},2,{"id":198,"slug":199,"hasResults":12,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":204,"targetDuration":4,"studyType":23,"phases":206,"briefSummary":207,"conditions":208,"keywords":212,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":51},"100617670","ultrasound-guided-regional-blocks-for-postoperative-analgesia-after-laparoscopic-cholecystectomy-100617670","NCT07321639","Ultrasound-Guided Regional Blocks for Postoperative Analgesia After Laparoscopic Cholecystectomy","Comparison of the Effectiveness of Ultrasound-Guided Recto-Intercostal Fascial Plane Block and Transversus Abdominis Plane Block in Postoperative Analgesia Management of Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* ASA physical status I-II\n* Scheduled for elective laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics or opioid medications\n* Infection at the planned block site\n* History of alcohol or drug dependence\n* Use of anticoagulant therapy\n* Refusal to participate in the study",{"count":205,"type":22},90,[25],"Ultrasound (US)-guided recto-intercostal fascial plane block (RIFPB) is a recently described abdominal wall block performed by injecting local anesthetic between the rectus abdominis muscle and the costal cartilage of the 7th rib. Due to the cranial attachment of the rectus muscle, this technique provides effective analgesia to the sternal, epigastric, and upper-mid abdominal regions, corresponding to the T6-T10\u002F11 dermatomal levels. RIFPB may be used as an adjunct technique for thoracic procedures or as a standalone block for abdominal surgery.\n\nUltrasound-guided transversus abdominis plane block (TAPB) is performed by injecting local anesthetic into the fascial plane between the internal oblique and transversus abdominis muscles. TAPB provides sensory blockade of the anterolateral abdominal wall at the T6-L1 dermatomal levels and is widely used for postoperative analgesia following abdominal surgeries, including laparoscopic cholecystectomy.\n\nThis study aims to compare the effectiveness of US-guided RIFPB and TAPB on postoperative pain control after laparoscopic cholecystectomy.",[29,209,210,211],"Acute Pain","Pain Management","Plane Blocks",[213,214,215,216,217,218],"Laparoscopic cholecystectomy","Postoperative analgesia","Recto-intercostal fascial plane block","Transversus abdominis plane block","Regional anesthesia","Opioid consumption","2026-06-10",{"date":221,"type":43},"2026-06-11",{"date":223,"type":43},"2026-01-19",{"date":225,"type":22},"2027-07-15",{"name":227,"class":50},"Istanbul Medipol University Hospital",{"id":229,"slug":230,"hasResults":12,"nctId":231,"briefTitle":232,"officialTitle":232,"acronym":4,"eligibilityCriteria":233,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":234,"enrollmentInfo":235,"targetDuration":4,"studyType":23,"phases":236,"briefSummary":237,"conditions":238,"keywords":240,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":51},"100642713","the-impact-of-ventilator-synchrony-on-muscle-relaxant-consumption-and-surgeon-satisfaction-during-laparoscopic-cholecystectomy-100642713","NCT07647770","The Impact of Ventilator Synchrony on Muscle Relaxant Consumption and Surgeon Satisfaction During Laparoscopic Cholecystectomy.","Inclusion Criteria:\n\n* Adults aged 18-60 years undergoing elective laparoscopic cholecystectomy.\n* ASA (American Society of Anesthesiologists) physical status I-II\n* BMI 18-35 kg\u002Fm²\n\nExclusion Criteria:\n\n* Severe COPD or restrictive lung disease\n* Neuromuscular disorders\n* Emergency surgery\n* Morbid obesity","60 Years",{"count":159,"type":22},[25],"The goal of this clinical trial is to investigate the Impact of adding SIMV Synchronization to our standard PCV-VG mode of ventilation on muscle relaxant consumption, the frequency of relaxant top-ups and surgeon satisfaction during Laparoscopic Cholecystectomy surgeries in ASA I\\&II. The main question it aims to answer is do Ventilator synchrony (PCV-VG+SIMV) reduces muscle relaxant consumption and improves surgeon satisfaction by minimizing the perception of inadequate paralysis?\n\nPrimary hypothesis: Ventilator synchrony (PCV-VG+SIMV) reduces muscle relaxant consumption and improves surgeon satisfaction by minimizing the perception of inadequate paralysis.\n\nPrimary outcome;\n\n1. Compare total intraoperative rocuronium consumption (mg\u002Fkg) between PCV-VG and PCV-VG + SIMV\n2. To determine the frequency of additional muscle relaxant requests",[239,65,29],"Muscle Relaxant Consumption",[241],"ventilator synchrony, muscle relaxant, laparoscopic cholecystectomy","2026-06-09",{"date":169,"type":43},{"date":245,"type":22},"2026-08",{"date":247,"type":22},"2029-06",{"name":249,"class":50},"Hitham Mohammed Aly Elsayed",{"id":251,"slug":252,"hasResults":12,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":4,"eligibilityCriteria":256,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":257,"enrollmentInfo":258,"targetDuration":4,"studyType":23,"phases":260,"briefSummary":261,"conditions":262,"keywords":263,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":51},"100618509","eoib-for-pain-after-laparoscopic-cholecystectomy-100618509","NCT07332546","EOIB for Pain After Laparoscopic Cholecystectomy","External Oblique Intercostal Block for Postoperative Pain After Laparoscopic Cholecystectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18-85 years, regardless of gender\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Scheduled for elective laparoscopic cholecystectomy\n* Ability to use the intravenous patient-controlled analgesia (IV PCA) system\n\nExclusion Criteria:\n\n* Hepatic disease (e.g., liver enzyme levels ≥ 2× the upper limit of normal)\n* Renal disease (e.g., serum creatinine levels ≥ 2× the upper limit of normal)\n* Allergy or known hypersensitivity to local anesthetics\n* Females who are pregnant or lactating\n* Conversion to open surgery\n* Coagulopathy or current use of anticoagulant medications\n* Opioid use for more than 2 weeks in the past 6 months","85 Years",{"count":259,"type":22},56,[25],"This prospective, randomized, controlled, assessor-blinded trial will evaluate whether bilateral ultrasound-guided external oblique intercostal block (EOIB) reduces postoperative opioid consumption and improves pain control after laparoscopic cholecystectomy, compared with no block.",[28,29],[264,265,38,266],"External oblique intercostal block","Ultrasonography, Interventional","Quality of recovery (QoR-15)","2026-06-06",{"date":242,"type":43},{"date":270,"type":43},"2026-01-15",{"date":272,"type":22},"2026-07-05",{"name":274,"class":50},"Shiyou Wei",{"id":276,"slug":277,"hasResults":12,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":4,"eligibilityCriteria":281,"healthyVolunteers":12,"sex":282,"minAge":283,"maxAge":4,"enrollmentInfo":284,"targetDuration":4,"studyType":23,"phases":286,"briefSummary":287,"conditions":288,"keywords":290,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":296,"leadSponsor":298,"locationsCount":300},"100638505","preventing-ovarian-cancer-through-opportunistic-salpingectomy-at-the-time-of-laparoscopic-cholecystectomy-100638505","NCT07625137","Preventing Ovarian Cancer Through Opportunistic Salpingectomy at the Time of Laparoscopic Cholecystectomy","Expanding Opportunistic Bilateral Salpingectomy to Laparoscopic Cholecystectomy to Prevent Ovarian Cancer: A Feasibility and Safety Trial","Inclusion Criteria:\n\n* Individuals with fallopian tubes who are undergoing lap chole and have more than 24 hours from surgeon consult to surgery, regardless of menopausal status\n* Age of 35 years and older\n* Patient must be able to give oral and written informed consent\n* Premenopausal patients will be included but will be counseled regarding their fertility\n\nExclusion Criteria:\n\n* Less than 24 hours available from surgeon consult to surgery\n* Individuals with a desire for a future pregnancy\n* Previously had a salpingectomy or salpingo-oophorectomy","FEMALE","35 Years",{"count":285,"type":22},240,[25],"This study aims to evaluate the feasibility, safety, and cost-effectiveness of opportunistic salpingectomy (OS-the removal of the fallopian tubes) at the time of laparoscopic cholecystectomy (the removal of the gallbladder) to prevent ovarian cancer. Ovarian cancer is the fifth leading cause of cancer-related mortality in females in Canada. OS can prevent the most common and lethal type of ovarian cancer, high-grade serous carcinoma (HGSC). OS during gynecologic surgery (hysterectomy or instead of tubal ligation) is safe and effective. However, rates of hysterectomies and tubal sterilization are decreasing. This research team aims to extend the prevention of ovarian cancer by expanding to offer OS during other surgeries in the abdomen, when patients are already undergoing a surgical procedure. This study will examine: 1) the feasibility of OS at the time of laparoscopic cholecystectomy; 2) the safety of OS at the time of laparoscopic cholecystectomy; 3) any health services consequences of offering OBS during laparoscopic cholecystectomy.\n\nThe hypothesis is that OS at the time of laparoscopic cholecystectomy is a feasible, safe, and cost-effective primary prevention strategy for ovarian cancer. It is also hypothesized that there will be 10-20 minutes of additional operating room time for completing OS, and that integrating the identified partners and knowledge users, as well as adding relevant knowledge users as the project progresses, will affect the rapid mobilization of our findings.",[289,29],"Salpingectomy",[289,291,292,34,29],"Ovarian Neoplasms","Primary prevention",{"date":294,"type":43},"2026-06-04",{"date":71,"type":22},{"date":297,"type":22},"2029-03-02",{"name":299,"class":50},"University of British Columbia",3,{"id":302,"slug":303,"hasResults":12,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":4,"eligibilityCriteria":307,"healthyVolunteers":12,"sex":17,"minAge":308,"maxAge":19,"enrollmentInfo":309,"targetDuration":4,"studyType":23,"phases":311,"briefSummary":312,"conditions":313,"keywords":316,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":51},"100639377","erector-spina-plane-block-versus-modified-thoracoabdominal-nerve-block-after-laparoscopic-cholecystectomy-100639377","NCT07624058","Erector Spina Plane Block Versus Modified Thoracoabdominal Nerve Block After Laparoscopic Cholecystectomy","Erector Spinae Plane Block Versus Modified Thoracoabdominal Nerve Block For Pain Control After Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Age: between 30 - 65\n* American Society of Anaesthesiologists physical status: I- III\n* Body mass index: 18-35 kg.m-2\n\nExclusion Criteria:\n\n* Patient Refusal\n* Allergy to local anaesthetic agents.\n* Skin infection at the site of injection.\n* Coagulopathy.\n* Diabetes Mellitus","30 Years",{"count":310,"type":22},50,[25],"direct comparisons between ESPB and M-TAPA for postoperative analgesia after LC remain limited. This is an important area of clinical interest because the two blocks differ significantly in their anatomical targets, mechanism of analgesia, and likely dermatomal coverage. The ESPB provides analgesia through paravertebral spread affecting both dorsal and ventral rami, thereby offering posterior and visceral pain relief, whereas M-TAPA directly targets the thoracoabdominal nerves, resulting in better anterior and lateral abdominal wall analgesia. Understanding which technique offers superior or more balanced analgesia could help to optimise regional anaesthesia strategies in LC and to improve patient outcomes.",[314,315,29],"Erector Spinae Block","Modified Thoracoabdominal Nerve Block",[317,318],"pain control","erector spinae block","2026-05-29",{"date":321,"type":43},"2026-06-03",{"date":323,"type":43},"2026-04-01",{"date":325,"type":22},"2027-03-01",{"name":327,"class":50},"Alexandria University",{"id":329,"slug":330,"hasResults":12,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":334,"eligibilityCriteria":335,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":336,"targetDuration":4,"studyType":23,"phases":338,"briefSummary":339,"conditions":340,"keywords":343,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":353,"locationsCount":4},"100636525","revised-paravertebral-nerve-blocks-for-enhanced-recovery-after-laparoscopic-cholecystectomy-100636525","NCT07566819","Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Laparoscopic Cholecystectomy","Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Laparoscopic Cholecystectomy: A Randomized Clinical Trial","REVISED-PVB II","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective laparoscopic cholecystectomy for benign gallbladder disease\n\nExclusion Criteria:\n\n* Contraindications to nerve block, including skin infection at the puncture site, increased intracranial pressure, uncorrectable coagulopathy, bridging indication for therapeutic anticoagulation (CHADS-VASc ≥ 8), sepsis, or allergy to local anesthetics\n* Surgeon-estimated high likelihood of conversion to open surgery\n* Chronic opioid use\n* Heart failure, liver failure, or renal failure\n* Coagulation disorders\n* History of allergy to local anesthetics\n* Inability to comply with the study protocol, including severe psychiatric illness, refusal to provide informed consent, or anticipated difficulty with postoperative follow-up",{"count":337,"type":22},250,[25],"After laparoscopic cholecystectomy, pain remains an important problem affecting patient recovery. A revised paravertebral block (r-PVB) was developed as a single-shot, large-volume intercostal-space injection performed at the exposed mid-axillary eighth or ninth intercostal level with the patient kept supine after induction of anesthesia. Rather than puncturing the classical paraspinal target near the transverse process with a specific prone or lateral position of the patient, r-PVB is designed to exploit medial spread of local anesthetic along the intercostal-endothoracic-extrapleural continuum, thereby generating a functional paravertebral block while avoiding direct entry into the paravertebral space and specific body positioning. r-PVB addresses several practical limitations of conventional PVB by eliminating the need to reposition an anesthetized patient, using a more accessible and potentially clearer sonographic window, reducing interference from transverse-process shadowing, and facilitating in-plane needle visualization.",[341,29,28,342],"Benign Gallbladder Disease","Quality of Recovery",[29,28,342,344,345],"Paravertebral Nerve Block","intercostal space block","2026-05-06",{"date":348,"type":43},"2026-05-11",{"date":350,"type":22},"2026-04-27",{"date":352,"type":22},"2027-12-31",{"name":354,"class":50},"Sixth Affiliated Hospital, Sun Yat-sen University",{"id":356,"slug":357,"hasResults":12,"nctId":358,"briefTitle":359,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":361,"targetDuration":4,"studyType":23,"phases":363,"briefSummary":364,"conditions":365,"keywords":368,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":371,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":377,"locationsCount":51},"100587913","de-implementation-of-low-value-testing-in-patients-undergoing-low-risk-surgery-100587913","NCT06934564","De-Implementation of Low-value Testing in Patients Undergoing Low-Risk Surgery","Site\n\nInclusion Criteria:\n\n* Over 30% of testing rates on at least one of the three index procedures (breast lumpectomy, laparoscopic cholecystectomy, and inguinal hernia repair)\n\nExclusion Criteria:\n\n* none\n\nSurgical participants must be over 18 years old.",{"count":362,"type":22},16,[25],"This trial aims to evaluate the effectiveness of a multi-level, multi-component de-implementation strategy to reduce unnecessary preoperative testing. Sixteen Michigan Value Collaborative (MVC)\u002FMichigan Surgical Quality Collaborative (MSQC) sites in Michigan will implement several tools that have been proven to reduce unnecessary testing at a single site, including clinician education, a decision aid, audit and feedback on performance, and a pay-for-performance incentive. The researchers believe that, through the use of these strategies, there will be a significant reduction in unnecessary preoperative testing during the intervention.",[366,29,367],"Breast Lumpectomy","Inguinal Hernia Repair",[369],"Preoperative testing","2026-05-05",{"date":372,"type":43},"2026-05-08",{"date":374,"type":43},"2025-04-01",{"date":376,"type":22},"2026-12",{"name":378,"class":50},"University of Michigan",{"id":380,"slug":381,"hasResults":12,"nctId":382,"briefTitle":383,"officialTitle":384,"acronym":385,"eligibilityCriteria":386,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":234,"enrollmentInfo":387,"targetDuration":4,"studyType":23,"phases":389,"briefSummary":390,"conditions":391,"keywords":397,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":402,"completionDateStruct":404,"leadSponsor":406,"locationsCount":51},"100635473","effect-of-preoperative-melatonin-on-quality-of-recovery-after-elective-laparoscopic-cholecystectomy-100635473","NCT07553143","Effect of Preoperative Melatonin on Quality of Recovery After Elective Laparoscopic Cholecystectomy","Effect of Preoperative Melatonin on Quality of Recovery After Elective Laparoscopic Cholecystectomy: A Randomized Controlled Trial","MEL-REC","Inclusion Criteria:\n\n* Age 18-60 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n* Able to understand and provide informed consent\n* Willing to participate in the study and complete follow-up assessments\n* Body mass index (BMI) 18-35 kg\u002Fm2\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to melatonin or placebo component\n* Chronic use of opioids, sedatives, or hypnotics (regular use for ≥4 weeks prior to surgery)\n* Current use of beta-adrenergic receptor antagonists (beta-blockers) (suppress endogenous melatonin secretion via inhibition of pineal β₁-adrenergic receptors)\n* History of psychiatric disorders requiring ongoing pharmacological treatment\n* Pregnancy or lactation\n* Severe hepatic impairment (Child-Pugh class B or C), as melatonin undergoes extensive first-pass hepatic metabolism via CYP1A2\n* Diagnosed obstructive sleep apnoea requiring continuous positive airway pressure\n* Diagnosed circadian rhythm disorder (e.g., delayed sleep phase disorder, advanced sleep phase disorder) requiring medical management\n* Use of exogenous melatonin supplements within 30 days prior to surgery\n* Inability to complete study questionnaires due to language barrier or cognitive impairment\n* History of substance abuse or dependence",{"count":388,"type":22},84,[25],"Laparoscopic cholecystectomy is one of the most commonly performed abdominal surgical procedures worldwide. Although the widespread implementation of Enhanced Recovery after Surgery (ERAS) protocols has improved perioperative outcomes, many patients continue to experience postoperative pain, sleep disturbance, anxiety, nausea, and fatigue, symptoms that collectively impair overall quality of recovery (QoR). Melatonin, an endogenous hormone that regulates circadian rhythm, also possesses anxiolytic, analgesic, antioxidant, and anti-inflammatory properties, positioning it as a valuable perioperative adjunct. However, most previous studies have evaluated melatonin primarily for isolated outcomes such as sleep quality or anxiety. Its effect on comprehensive postoperative recovery, assessed using validated patient-reported outcome instruments, remains insufficiently explored, particularly in laparoscopic cholecystectomy populations and in South Asian clinical settings.\n\nThis prospective, randomized, double-blind, placebo-controlled trial (the MEL-REC trial) aims to evaluate the effect of preoperative oral melatonin on postoperative quality of recovery in patients undergoing elective laparoscopic cholecystectomy under general anaesthesia. The study will be conducted in the Department of Anaesthesiology at Combined Military Hospital (CMH), Dhaka, Bangladesh, over a total study period of 18 months (January 2026 to June 2027), with patient recruitment planned for 8 months (May to December 2026) after taking approval from institutional review board. Eighty four adult patients aged 18-60 years with American Society of Anesthesiologists (ASA) physical status I-II will be randomly allocated in a 1:1 ratio into two equal groups (n = 42 per group) using computer-generated permuted block randomization with centralized pharmacy based allocation concealment. The melatonin group (Group M) will receive oral melatonin 6 mg administered 60 minutes before induction of anaesthesia and the placebo group (Group P) will receive an identical placebo tablet under the same conditions. Neither the participants, the treating anaesthesiologist, the outcome assessor, nor the data analyst will be aware of group allocation until database lock. All patients will receive a standardized anaesthesia and perioperative management protocol, including standardized postoperative analgesia.\n\nThe primary outcome will be postoperative quality of recovery assessed using the Quality of Recovery-15 (QoR-15) score at 24 ± 2 hours after surgery. Secondary outcomes include postoperative sleep quality measured by the Richards-Campbell Sleep Questionnaire, change in preoperative anxiety (delta-VAS-A score), total opioid consumption during the first 24 hours expressed as intravenous morphine milligram equivalents, incidence of postoperative nausea and vomiting, and time to first rescue analgesic request. All postoperative outcomes will be assessed by a trained research assistant blinded to group allocation.\n\nBased on the available evidence, it is anticipated that patients receiving preoperative melatonin will demonstrate higher QoR-15 scores at 24 hours after surgery compared with the placebo group. The melatonin group is also expected to have improved postoperative sleep quality, reduced opioid consumption, and a greater reduction in preoperative anxiety.\n\nIf a clinically meaningful benefit is confirmed, given its well established safety profile, low cost, and ease of oral administration, preoperative melatonin may represent a practical perioperative adjunct that can be readily incorporated into ERAS protocols for laparoscopic cholecystectomy. The trial will be prospectively registered in the Bangladesh Medical Research Council (BMRC) clinical trial registry or clinicaltrials.gov prior to recruitment.",[29,392,393,394,395,396],"Postoperative Quality of Recovery","Preoperative Anxiety","Postoperative Sleep Quality","Opioid Consumption, Postoperative","PONV in Laparoscopic Cholocystectomies",[392,398,399,29],"QoR-15","Melatonin","2026-04-29",{"date":370,"type":43},{"date":403,"type":22},"2026-05-01",{"date":405,"type":22},"2027-06-30",{"name":407,"class":50},"Armed Forces Medical Institute Bangladesh",{"id":409,"slug":410,"hasResults":12,"nctId":411,"briefTitle":412,"officialTitle":413,"acronym":414,"eligibilityCriteria":415,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":416,"targetDuration":4,"studyType":23,"phases":418,"briefSummary":420,"conditions":421,"keywords":423,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":425,"startDateStruct":427,"completionDateStruct":429,"leadSponsor":430,"locationsCount":51},"100607587","phase-4-ginger-to-prevent-nausea-and-vomiting-after-laparoscopic-cholecystectomy-100607587","NCT07190495","Ginger to Prevent Nausea and Vomiting After Laparoscopic Cholecystectomy","Preoperative Ginger for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy: A Double-Blind Randomized Controlled Trial","GINGER-PONV","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Able to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to ginger\n* Documented history of bleeding disorders or current treatment with anticoagulant agents\n* History of severe postoperative nausea and vomiting or an Apfel score of 4\n* Administration of antiemetic drugs or corticosteroids during the preoperative period\n* Pregnancy or breastfeeding\n* Active gastrointestinal or liver disease",{"count":417,"type":22},102,[419],"PHASE4","This study aims to evaluate whether preoperative oral administration of ginger (800 mg, given 2 hours before surgery) reduces the incidence and severity of postoperative nausea and vomiting (PONV) within the first 24 hours after laparoscopic cholecystectomy.",[422,29],"Postoperative Nausea and Vomiting",[424,422,29],"Ginger",{"date":426,"type":43},"2026-04-28",{"date":428,"type":43},"2025-07-05",{"date":376,"type":22},{"name":431,"class":50},"University Tunis El Manar",{"id":433,"slug":434,"hasResults":12,"nctId":435,"briefTitle":436,"officialTitle":437,"acronym":4,"eligibilityCriteria":438,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":439,"targetDuration":4,"studyType":23,"phases":441,"briefSummary":442,"conditions":443,"keywords":445,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":456,"lastUpdatePostDateStruct":457,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":462,"locationsCount":51},"100626832","low-flow-sevoflurane-and-desflurane-anesthesia-in-laparoscopic-cholecystectomy-100626832","NCT07440758","Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy","The Effect of Low-Flow Sevoflurane and Low-Flow Desflurane Anesthesia on Postoperative Sore Throat in Laparoscopic Cholecystectomy Surgery","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Aged between 18 and 65 years\n* Patients who provide written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients with a recent history of upper respiratory tract infection\n* Patients with a recent history of sore throat\n* Patients with chronic cough\n* Patients with a history of previous neck or tracheal surgery\n* Patients with predictors of difficult intubation\n* Patients with a history of difficult intubation\n* Obese patients (BMI \\> 35 kg\u002Fm²)\n* Patients with chronic respiratory diseases (asthma, COPD)\n* Pregnancy\n* Use of dexamethasone\n* Patients with hepatic impairment\n* Patients with allergy to paracetamol, tramadol, granisetron, dexamethasone, or metoclopramide\n* Patients with known allergy to halogenated anesthetic agents\n* Patients with a history of malignant hyperthermia\n* Patients with mental disorders or those unable to provide reliable assessment",{"count":440,"type":22},70,[25],"Several studies have demonstrated that inhalational anesthetic agents such as desflurane and sevoflurane may cause varying degrees of postoperative sore throat, hoarseness, and cough in orotracheally intubated patients. However, data evaluating these outcomes under low-flow anesthesia conditions remain limited and insufficient.\n\nThis single-center, prospective, randomized controlled study will be conducted in patients aged 18-65 years, classified as American Society of Anesthesiologists (ASA) physical status I-II, who are scheduled to undergo elective laparoscopic cholecystectomy under general anesthesia and who provide written informed consent to participate in the study.\n\nThe primary objective of the study is to compare the effects of low-flow desflurane and low-flow sevoflurane anesthesia on the incidence and severity of postoperative sore throat.\n\nThe secondary outcomes include the evaluation of postoperative hoarseness and cough, the incidence of postoperative nausea and vomiting (PONV), and the total consumption of inhalational anesthetic agents.",[29,444],"Postoperative Sore Throat",[446,447,448,449,213,450,451,452,453,454,455],"Postoperative sore throat","Low-flow anesthesia","Sevoflurane","Desflurane","General anesthesia","Orotracheal intubation","Endotracheal cuff pressure","Postoperative complications","Postoperative nausea and vomiting","PONV","2026-04-24",{"date":350,"type":43},{"date":459,"type":43},"2026-03-20",{"date":461,"type":22},"2026-07-30",{"name":463,"class":101},"Kayseri City Hospital",{"id":465,"slug":466,"hasResults":12,"nctId":467,"briefTitle":468,"officialTitle":469,"acronym":4,"eligibilityCriteria":470,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":234,"enrollmentInfo":471,"targetDuration":4,"studyType":23,"phases":473,"briefSummary":475,"conditions":476,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":481,"leadSponsor":483,"locationsCount":51},"100630469","phase-1-effect-of-liberal-and-restrictive-iv-fluids-on-recovery-after-gallbladder-surgery-100630469","NCT07488078","Effect of Liberal and Restrictive IV Fluids on Recovery After Gallbladder Surgery","Effect of Liberal Versus Restrictive Intravenous Fluid Administration on Postoperative Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* All patients undergoing elective cholecystectomy\n* Age : 18-60 years\n* All genders\n* ASA class 1 and 2\n\nExclusion Criteria:\n\n* History of previous laparotomy\n* Perforated gall bladder\n* Duration of surgery more than 3 hours\n* More than 100ml intra operative blood loss",{"count":472,"type":22},380,[474],"PHASE1","The goal of this clinical trial is to learn whether giving less intravenous (IV) fluid (restrictive administration) after surgery is as effective as giving more IV fluid (liberal administration) in maintaining body stability (homeostasis) among adults undergoing laparoscopic gallbladder removal (cholecystectomy).\n\nThe main questions it aims to answer are:\n\nDoes restrictive IV fluid administration maintain stable blood pressure, heart rate, and urine output after laparoscopic cholecystectomy?\n\nAre there any differences in postoperative recovery or complications between restrictive and liberal fluid regimens?\n\nResearchers will compare patients receiving liberal IV fluid administration with those receiving restrictive IV fluid administration to see if both methods maintain similar postoperative homeostasis and recovery outcomes.\n\nParticipants will:\n\nBe adults aged 18-60 years (ASA class I-II) undergoing elective laparoscopic cholecystectomy.\n\nBe randomly assigned to one of two groups:\n\nGroup A: Liberal IV fluid administration for 6 hours after surgery.\n\nGroup B: Restrictive IV fluid administration for 6 hours after surgery.\n\nHave their vital signs (pulse, blood pressure, mean arterial pressure) and urine output recorded at multiple time points after surgery (immediate, 3, 6, 12, and 24 hours).",[29],"2026-03-17",{"date":479,"type":43},"2026-03-23",{"date":45,"type":43},{"date":482,"type":22},"2026-07-28",{"name":484,"class":50},"King Edward Medical University",{"id":486,"slug":487,"hasResults":12,"nctId":488,"briefTitle":489,"officialTitle":490,"acronym":4,"eligibilityCriteria":491,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":492,"enrollmentInfo":493,"targetDuration":4,"studyType":23,"phases":495,"briefSummary":496,"conditions":497,"keywords":498,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":502,"lastUpdatePostDateStruct":503,"startDateStruct":505,"completionDateStruct":507,"leadSponsor":509,"locationsCount":51},"100626846","timing-of-subcostal-tapb-combined-with-rectus-sheath-block-for-postoperative-pain-after-laparoscopic-cholecystectomy-100626846","NCT07440940","Timing of Subcostal TAPB Combined With Rectus Sheath Block for Postoperative Pain After Laparoscopic Cholecystectomy","Effect of Timing of Ultrasound-Guided Subcostal Transversus Abdominis Plane Block Combined With Rectus Sheath Block on Postoperative Pain in Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Elective laparoscopic cholecystectomy\n* Adults aged 18 to 80 years\n* Ability to understand the study procedures and provide informed consent\n* American Society of Anesthesiologists (ASA) physical status I-III\n\nExclusion Criteria:\n\n* Presence of significant pain unrelated to the target disease that may interfere with pain assessment\n* Known allergy or contraindication to study medications (ropivacaine, acetaminophen, nefopam, or pethidine)\n* Planned single-port laparoscopic cholecystectomy\n* American Society of Anesthesiologists (ASA) physical status IV or higher\n* Infection of the abdominal wall or skin at the injection site, or anatomical abnormalities of the abdominal wall\n* Major neurological, psychiatric, or systemic diseases that may affect pain perception, treatment response, or study evaluation\n* Requirement for postoperative mechanical ventilation\n* Pregnancy or breastfeeding\n* Considered unsuitable for the study by the investigator\n* Refusal to participate or inability to provide informed consent","80 Years",{"count":494,"type":22},96,[25],"This prospective randomized controlled trial aims to evaluate whether the timing of ultrasound-guided subcostal transversus abdominis plane (TAP) block combined with rectus sheath block (RSB) affects postoperative pain in patients undergoing laparoscopic cholecystectomy.\n\nParticipants will be randomly assigned to receive the combined regional blocks either before surgical incision or after completion of surgery. The primary outcome is postoperative pain intensity measured using a numerical rating scale. Secondary outcomes include opioid consumption, incidence of postoperative nausea and vomiting, and other recovery parameters.\n\nThe results of this study may help optimize the timing of abdominal wall blocks to improve postoperative analgesia and recovery following laparoscopic cholecystectomy.",[28,29],[29,499,500,501],"Transversus Abdominis Plane Block","Rectus Sheath Block","Postoperative pain","2026-02-25",{"date":504,"type":43},"2026-02-27",{"date":506,"type":43},"2026-02-23",{"date":508,"type":22},"2027-01-15",{"name":510,"class":50},"Eulji University Hospital",{"id":512,"slug":513,"hasResults":12,"nctId":514,"briefTitle":515,"officialTitle":516,"acronym":4,"eligibilityCriteria":517,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":518,"enrollmentInfo":519,"targetDuration":4,"studyType":521,"phases":4,"briefSummary":522,"conditions":523,"keywords":526,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":502,"lastUpdatePostDateStruct":533,"startDateStruct":535,"completionDateStruct":537,"leadSponsor":538,"locationsCount":51},"100627224","sensory-analysis-and-cutaneous-mapping-of-different-regional-anesthesia-techniques-100627224","NCT07445854","Sensory Analysis and Cutaneous Mapping of Different Regional Anesthesia Techniques","Sensory Analysis and Cutaneous Mapping of Different Regional Anesthesia Techniques in Laparoscopic Cholecystectomy Surgery: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients scheduled for elective laparoscopic cholecystectomy surgery and who have received a regional anesthesia technique for this purpose.\n* Aged between 18-75 years.\n* Belonging to ASA I-III group.\n* Having provided written informed consent.\n\nExclusion Criteria:\n\n* Patients who refuse to participate.\n* Patients who did not receive a block.\n* Patients classified as ASA IV.\n* History of previous abdominal surgery (affecting the laparoscopic approach).\n* Patients with cognitive dysfunction or inability to cooperate.\n* Patients diagnosed with psychiatric disorders (schizophrenia, mania, depression, etc.).\n* Patients who have been using antipsychotic medication for more than 4 weeks.","75 Years",{"count":520,"type":22},40,"OBSERVATIONAL","This prospective observational study aims to evaluate and compare the sensory block distribution and regression patterns of two regional anesthesia techniques - External Oblique Plane Block (EOPB) and Serratus Intercostal Plane Block (SIPB) - in patients undergoing laparoscopic cholecystectomy.\n\nThirty adult patients (ASA I-III, BMI ≤ 35 kg\u002Fm², ≥50 kg) scheduled for elective laparoscopic cholecystectomy procedures will be included, with 20 in each block group. Sensory block areas will be assessed using pinprick test, and dermatomal mapping will visualize the spread. The findings are expected to improve understanding of block behavior and guide multimodal analgesia strategies in laparoscopic cholecystectomy.",[29,524,525],"Postoperative Pain Management","Regional Anesthesia",[527,210,528,529,530,531,532],"regional anesthesia","Sensory Mapping","serratus intercostal plane block","external oblique plane block","eopb","sipb",{"date":534,"type":43},"2026-03-03",{"date":536,"type":43},"2025-11-15",{"date":127,"type":22},{"name":539,"class":50},"Samsun University",{"id":541,"slug":542,"hasResults":12,"nctId":543,"briefTitle":544,"officialTitle":545,"acronym":4,"eligibilityCriteria":546,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":547,"targetDuration":4,"studyType":23,"phases":548,"briefSummary":550,"conditions":551,"keywords":552,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":558,"lastUpdatePostDateStruct":559,"startDateStruct":561,"completionDateStruct":563,"leadSponsor":564,"locationsCount":196},"100607303","phase-3-ai-and-safety-in-laparoscopic-cholecystectomy-a-randomized-controlled-trial-100607303","NCT07186803","AI and Safety in Laparoscopic Cholecystectomy: A Randomized Controlled Trial","Evaluating the Clinical Impact of Artificial Intelligence on Safety in Laparoscopic Cholecystectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Surgeon participants: Attending surgeons or fellows that perform laparoscopic cholecystectomy at University Health Network.\n* Patients participants: Adults 18 years of age and over, scheduled for laparoscopic cholecystectomy surgery.\n\nExclusion Criteria:\n\n* Surgeon participants: Anyone who is not a surgeon or fellow at University Health Network or that does not perform laparoscopic cholecystectomies.\n* Patient participants: Any patient who is not having a laparoscopic cholecystectomy surgery.",{"count":440,"type":22},[549],"PHASE3","Today, the majority of gallbladder removals surgeries are done using minimally invasive techniques through small cuts to help patients recover faster. However, these procedures are technically more challenging because surgeons have a restricted view of the patient's anatomy, which can increase the risk of serious complications. Artificial intelligence (AI) tools have been developed to guide surgeons during surgery and help them make safer decisions that reduce the risk of injury to the patient. This study will use a randomized controlled trial to compare outcomes between surgeries with AI assistance and standard procedures without AI.\n\nPrimary Objective: To determine whether the AI improves surgeons' ability to achieve the Critical View of Safety, a key step for safe gallbladder removal, compared to standard procedures.\n\nSecondary Objectives:\n\n* Determine whether the AI helps the surgeon perform more safe dissections compared to the standard procedures.\n* Collect surgeon feedback on the use of AI during the procedure",[29],[553,554,555,556,557],"artificial intelligence","laparoscopic cholecystectomy","safety","critical view of safety","line of safety","2026-01-12",{"date":560,"type":43},"2026-01-13",{"date":562,"type":43},"2025-09-17",{"date":461,"type":22},{"name":565,"class":50},"University Health Network, Toronto",{"id":567,"slug":568,"hasResults":12,"nctId":569,"briefTitle":570,"officialTitle":571,"acronym":4,"eligibilityCriteria":572,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":573,"targetDuration":4,"studyType":23,"phases":575,"briefSummary":576,"conditions":577,"keywords":581,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":588,"lastUpdatePostDateStruct":589,"startDateStruct":591,"completionDateStruct":593,"leadSponsor":594,"locationsCount":51},"100602646","hot-water-foot-bath-for-pain-and-gas-relief-after-laparoscopic-cholecystectomy-100602646","NCT07126223","Hot Water Foot Bath for Pain and Gas Relief After Laparoscopic Cholecystectomy","The Effect of Hot Water Foot Bath on Pain and Gas Release After Laparoscopic Cholecystectomy: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Age 18 years or older\n* Undergoing elective laparoscopic cholecystectomy\n* Received the same preoperative gastrointestinal preparation protocol\n* Received the same postoperative analgesia protocol\n* Numeric Rating Scale (NRS) pain score of 3 or higher at the 3rd postoperative hour\n* Voluntarily agreed to participate and signed the informed consent form\n* Classified as ASA I or ASA II according to the American Society of Anesthesiologists (ASA)\n\nExclusion Criteria:\n\n* Undergoing emergency cholecystectomy or open surgery (laparotomy)\n* Presence of open wounds, infections, circulatory disorders, or lesions in the feet (hot foot bath area)\n* Use of patient-controlled analgesia (PCA) in the early postoperative period\n* Any condition that impairs verbal communication\n* History of inflammatory bowel disease (due to potential influence on bowel motility)\n* Use of medications or probiotic agents affecting bowel motility in the pre- or postoperative period",{"count":574,"type":22},62,[25],"This study investigates the effects of a hot foot bath on postoperative pain and time to first gas release in patients undergoing laparoscopic cholecystectomy. The intervention is a non-pharmacological supportive method applied during the early postoperative period. Participants will be randomly assigned to either intervention or control groups. No FDA-regulated drug or device is involved.",[29,28,578,579,580],"Gastrointestinal Motility","Postoperative Recovery","Nursing Interventions",[582,583,584,585,586,587],"foot bath","gas release","pain management","complementary therapy","nursing","cholesistectomy","2025-12-04",{"date":590,"type":43},"2025-12-05",{"date":592,"type":22},"2025-12-20",{"date":40,"type":22},{"name":595,"class":50},"Cansu Mert",{"id":597,"slug":598,"hasResults":12,"nctId":599,"briefTitle":600,"officialTitle":601,"acronym":602,"eligibilityCriteria":603,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":604,"targetDuration":4,"studyType":23,"phases":606,"briefSummary":607,"conditions":608,"keywords":612,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":623,"lastUpdatePostDateStruct":624,"startDateStruct":626,"completionDateStruct":627,"leadSponsor":629,"locationsCount":51},"100610797","effects-of-intraoperative-warming-methods-on-hematologic-inflammatory-indices-in-laparoscopic-cholecystectomy-100610797","NCT07232251","Effects of Intraoperative Warming Methods on Hematologic Inflammatory Indices in Laparoscopic Cholecystectomy","Evaluation of the Effects of Different Intraoperative Warming Techniques on Core Body Temperature and Hematologic Inflammatory Indices (SII, NLR, PLR, LMR) in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Study","WARM-CHOL","Inclusion Criteria:\n\n* Patients scheduled for elective laparoscopic cholecystectomy.\n* ASA (American Society of Anesthesiologists) physical status I-III.\n* Age between 18 and 65 years.\n* Willingness and ability to provide written informed consent.\n\nExclusion Criteria:\n\n* ASA IV-V patients.\n* Emergency surgery requirement.\n* Preoperative fever (\\>38.0 °C) or hypothermia (\\\u003C36.0 °C).\n* Operation duration \\\u003C60 minutes or \\>180 minutes.\n* Endocrine\u002Fmetabolic disorders affecting body temperature (e.g., moderate-severe thyroid dysfunction, pheochromocytoma, severe dysautonomia, malnutrition).\n* Active infection\u002Fsepsis or systemic infection within past 2 weeks.\n* Chronic immunosuppressive therapy (e.g., ≥10 mg\u002Fday prednisolone equivalent ≥2 weeks or biological agents in the past month).\n* Hematologic disorders (e.g., leukemia, aplastic anemia, myeloproliferative disorders) or abnormal blood counts (platelet \\\u003C100 ×10⁹\u002FL, leukocyte \\\u003C3 ×10⁹\u002FL).\n* Active malignancy or ongoing chemotherapy\u002Fradiotherapy in last 3 months.\n* Severe organ failure (Child-Pugh C liver, eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m² or dialysis, NYHA III-IV heart failure, GOLD III-IV COPD).\n* Coagulopathy or uncontrolled antithrombotic therapy.\n* Pregnancy or lactation.\n* Conversion from laparoscopic to open surgery.\n* Non-adherence to assigned warming protocol.\n* Inability to place esophageal temperature probe or unreliable temperature monitoring.\n* Intraoperative hemodynamic instability requiring prolonged vasopressor support or blood transfusion.\n* Missing or incomplete preoperative or postoperative CBC preventing calculation of inflammatory indices.\n* Withdrawal of consent or loss to follow-up.",{"count":605,"type":22},128,[25],"Perioperative hypothermia is a frequent and preventable complication that may cause adverse outcomes such as increased blood loss, impaired coagulation, and delayed recovery. Various active warming techniques are used to maintain normothermia during anesthesia; however, their comparative effects on systemic inflammatory responses remain unclear.\n\nThis randomized controlled clinical trial aims to evaluate the effects of different intraoperative warming methods on hematologic inflammatory indices - including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) - in patients undergoing elective laparoscopic cholecystectomy under general anesthesia.\n\nA total of eligible adult patients will be randomly assigned into four groups according to the intraoperative warming method applied:\n\nControl Group: No active warming applied.\n\nForced-Air Warming (FAW) Group: Warming blanket system used throughout surgery.\n\nFluid Warming (FW) Group: Intravenous fluids warmed to maintain normothermia.\n\nCombined Warming (FAW + FW) Group: Both forced-air and fluid warming applied simultaneously.\n\nCore body temperature and perioperative data will be recorded. Venous blood samples will be obtained preoperatively and 24 hours postoperatively to calculate inflammatory indices.\n\nThe primary objective is to determine whether active intraoperative warming techniques modulate postoperative inflammatory markers compared to no warming. Secondary outcomes include intraoperative temperature trends, recovery times, and the incidence of hypothermia-related complications.\n\nThe results are expected to identify the most effective warming strategy to minimize inflammation and optimize postoperative recovery in laparoscopic procedures.",[609,610,29,611],"Inflammatory Response","Perioperative Hypothermia","Surgical Stress Response",[613,614,615,616,617,618,619,620,621,622,34],"Intraoperative warming","Forced-air warming","Combined warming","Hypothermia prevention","Fluid warming","Hematologic inflammatory indices","Neutrophil-to-lymphocyte ratio (NLR)","Platelet-to-lymphocyte ratio (PLR)","Systemic immune-inflammation index (SII)","Laparoscopic surgery","2025-11-17",{"date":625,"type":43},"2025-11-19",{"date":45,"type":22},{"date":628,"type":22},"2026-04-02",{"name":630,"class":50},"Ataturk University",{"id":632,"slug":633,"hasResults":12,"nctId":634,"briefTitle":635,"officialTitle":635,"acronym":4,"eligibilityCriteria":636,"healthyVolunteers":12,"sex":17,"minAge":637,"maxAge":638,"enrollmentInfo":639,"targetDuration":4,"studyType":23,"phases":641,"briefSummary":642,"conditions":643,"keywords":645,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":648,"lastUpdatePostDateStruct":649,"startDateStruct":651,"completionDateStruct":653,"leadSponsor":655,"locationsCount":51},"100561331","ultrasound-guided-modified-thoracoabdominal-nerve-block-through-perichondrial-approach-m-tapa-versus-quadratus-lumborum-block-for-postoperative-analgesia-in-laparoscopic-cholecystectomy-100561331","NCT06588777","Ultrasound Guided Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) Versus Quadratus Lumborum Block for Postoperative Analgesia in Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Adult patients aging ≥ 21 years to ≤ 70 of both sexes.\n* Patients undergoing Laparoscopic cholecystectomy surgeries.\n* ASA physical status classes I - II.\n\nExclusion Criteria:\n\n* Patient's refusal of procedure or participation in the study.\n* ASA classes III or above.\n* Coagulopathy and bleeding disorders.\n* Evidence of Local skin infections at site of injection.\n* Body mass index \\>40kg\u002Fm2\n* A history of relevant local anesthetic allergy.","21 Years","71 Years",{"count":640,"type":22},52,[25],"This study aims to compare the efficacy of using Ultrasound guided modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) versus quadratus lumborum block for postoperative analgesia in laparoscopic cholecystectomy under general anesthesia.",[29,315,644],"Quadratus Lumborum Block",[213,646,647],"modified thoracoabdominal nerve block","quadratus lumborum block","2025-09-29",{"date":650,"type":43},"2025-09-30",{"date":652,"type":43},"2024-09-01",{"date":654,"type":22},"2025-12-30",{"name":656,"class":50},"Ain Shams University",{"id":658,"slug":659,"hasResults":12,"nctId":660,"briefTitle":661,"officialTitle":662,"acronym":663,"eligibilityCriteria":664,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":234,"enrollmentInfo":665,"targetDuration":4,"studyType":23,"phases":667,"briefSummary":668,"conditions":669,"keywords":673,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":681,"lastUpdatePostDateStruct":682,"startDateStruct":684,"completionDateStruct":686,"leadSponsor":688,"locationsCount":51},"100607709","comparative-efficacy-of-intravenous-labetalol-and-lignocaine-in-mitigating-hemodynamic-responses-to-laryngoscopy-during-laparoscopic-cholecystectomy-100607709","NCT07192081","Comparative Efficacy of Intravenous Labetalol and Lignocaine in Mitigating Hemodynamic Responses to Laryngoscopy During Laparoscopic Cholecystectomy","Comparative Efficacy of Intravenous Labetalol and Lignocaine in Mitigating Hemodynamic Responses to Laryngoscopy During Laparoscopic Cholecystectomy: A Randomized Controlled Trial","LAB-LIG RCT","Inclusion Criteria:\n\n* ASA Grade I and II\n* Age 18 to 60 years\n* Elective laparoscopic cholecystectomy\n* Both genders\n* Informed consent given\n\nExclusion Criteria:\n\n* Hypersensitivity to labetalol\u002Flignocaine\n* Hypertensive on antihypertensives\n* ASA Grade III or more\n* Cardiovascular, renal, hepatic, or endocrine issues\n* Pregnant\u002Flactating\n* BMI ≥ 35\n* Anticipated difficult airway",{"count":666,"type":22},116,[25],"Laryngoscopy and intubation during laparoscopic cholecystectomy often cause sudden increases in heart rate and blood pressure, which can be harmful in some patients. Medications such as labetalol and lignocaine are commonly used to reduce this hemodynamic response. This randomized controlled trial at Hayatabad Medical Complex, Peshawar, will compare intravenous labetalol (0.25 mg\u002Fkg) and lignocaine (1.5 mg\u002Fkg), administered 3 minutes before laryngoscopy. A total of 116 patients undergoing elective laparoscopic cholecystectomy will be randomly assigned to either drug group. The primary goal is to determine which drug is more effective in keeping heart rate and mean arterial pressure within ±20% of baseline during and after intubation. The study will also record blood pressure trends, intubation details, rescue medications, and adverse events such as bradycardia or hypotension. Results will help guide anesthesiologists in selecting the safer and more effective option to maintain cardiovascular stability during surgery.",[670,671,29,672],"Intubation","Anesthesia","Hemodynamic Response to Laryngoscopy",[674,675,676,677,678,679,680],"Attenuation of Sympathetic Response","Perioperative Management","Randomized Controlled Trial","Endotracheal Intubation","Hemodynamic Stability","Lignocaine","Labetalol","2025-09-21",{"date":683,"type":43},"2025-09-25",{"date":685,"type":43},"2025-06-05",{"date":687,"type":22},"2026-02-28",{"name":689,"class":101},"Dr. Waseem Ullah"]