[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"laparoscopic-gynecological-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:laparoscopic-gynecological-surgery":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100617700","effect-of-intrathecal-morphine-on-quality-of-recovery-after-laparoscopic-gynecological-surgery-100617700",false,"NCT07322029","Effect of Intrathecal Morphine on Quality of Recovery After Laparoscopic Gynecological Surgery","Inclusion Criteria:\n\n* Female patients aged ≥18 years.\n* Scheduled for elective laparoscopic gynecological surgery under general anesthesia.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Able to provide written informed consent.\n\nExclusion Criteria:\n\n* Contraindications to neuraxial anesthesia.\n* Allergy to morphine or local anesthetics.\n* Long-term opioid use (\\>20 morphine milligram equivalents per day).\n* Baseline NRS pain score \\>3.\n* Cognitive impairment or inability to cooperate.\n* Emergency or non-elective surgery.","FEMALE","18 Years",{"count":18,"type":19},252,"ESTIMATED","INTERVENTIONAL",[22],"NA","Minimally invasive gynecologic surgery has become the standard approach for the treatment of benign and malignant gynecologic diseases, offering the advantages of reduced surgical trauma and faster recovery. However, postoperative pain remains a major barrier to optimal recovery, with up to 40% of patients experiencing moderate to severe pain within the first 24 hours after laparoscopic procedures. Laparoscopic gynecologic surgery typically induces both somatic pain from abdominal wall incisions and visceral pain caused by peritoneal traction and pneumoperitoneum, making effective analgesia challenging. Transversus abdominis plane block (TAPB) is commonly used to control somatic incisional pain but provides limited relief of visceral pain, often resulting in increased opioid consumption and opioid-related adverse effects such as dizziness and postoperative nausea and vomiting. Intrathecal morphine (ITM) offers potent and long-lasting visceral analgesia with minimal systemic opioid requirements and has demonstrated safety and efficacy across multiple surgical settings. The complementary analgesic mechanisms of TAPB and intrathecal morphine suggest that their combination may enhance postoperative recovery by improving pain control while reducing opioid use.\n\nThe objective of this randomized controlled trial is to evaluate whether the combination of intrathecal morphine and TAPB improves the quality of recovery after laparoscopic gynecologic surgery compared with TAPB alone. This study aims to provide high-quality clinical evidence to guide the development of an optimized multimodal analgesia strategy for patients undergoing minimally invasive gynecologic procedures.",[25],"Laparoscopic Gynecological Surgery",[27,28,29],"laparoscopic gynecological surgery","QoR-15","Intrathecal morphine","NOT_YET_RECRUITING","2026-01-06",{"date":33,"type":34},"2026-01-07","ACTUAL",{"date":36,"type":19},"2026-01",{"date":38,"type":19},"2027-03",{"name":40,"class":41},"Sun Yat-sen University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":20,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":5},"100511225","eeg-and-ani-guided-anesthesia-and-quality-of-recovery-100511225","NCT05936671","EEG and ANI Guided Anesthesia and Quality of Recovery","Quality of Recovery After Electroencephalogram and Nociception Level-guided Versus Standard Anesthesia Care in Female Patients Undergoing Laparoscopic Gynecological Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\nAdult female patients who are scheduled to undergo laparoscopic gynecological surgery.\n\n1. Total laparoscopic hysterectomy with\u002Fwithout salpingo-oophorectomy\n2. Laparoscopic myomectomy\n3. Laparoscope-guided salpingo-oophorectomy\n4. Laparoscope-guided ovarian cystectomy\n5. Laparoscope-guided enucleation of ovarian cyst\n\nExclusion Criteria:\n\n1. Patients with nonregular sinus cardiac rhythm\n2. Patients with implanted pacemakers\n3. Patients on antimuscarinic agents, α2-adrenergic agonists, β1-adrenergic antagonists, antiarrhythmic agents\n4. pregnant or breastfeeding women\n5. Patients who are unable to communicate","19 Years",{"count":52,"type":19},126,[22],"This study aims to assess whether electroencephalogram (EEG) and nociception level-guided anesthesia can improve quality of recovery after laparoscopic gynecological surgery compared with standard care. Patients will be randomly assigned to either EEG and Analgesia Nociception Index (ANI)-guided anesthesia group (EEG-and-ANI-Guided group) or usual care group (control group). Primary outcome is 15-item Quality of Recovery (QoR-15) score at postoperative day (POD) 1. Secondary outcomes included remifentanil consumption during anesthesia, occurrence of awareness with recall, incidence of undesirable intraoperative movement, emergence time, postoperative pain scores, quality of recovery score at POD 2, and length of hospital stay.",[25],"RECRUITING","2024-08-14",{"date":59,"type":34},"2024-08-15",{"date":61,"type":34},"2023-07-13",{"date":63,"type":19},"2025-06-25",{"name":65,"class":41},"Gangnam Severance Hospital"]