[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"laparoscopic-hysterectomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:laparoscopic-hysterectomy":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,48,72,98,127,159,184,209,235,259,286],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100628865","effect-of-trendelenburg-position-on-patient-state-index-100628865",false,"NCT07467200","Effect of Trendelenburg Position on Patient State Index","Effect of the Trendelenburg Position on Patient State Index and Frontal Cerebral Oxygenation: A Prospective Observational Study","Inclusion Criteria:\n\n* Female patients aged 18-65 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective laparoscopic hysterectomy under general anesthesia\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* History of neurological disease (e.g., stroke, epilepsy)\n* Known cerebrovascular disease, glaucoma, or retinal disease\n* Severe cardiac or pulmonary disease\n* Contraindication to near-infrared spectroscopy sensor placement\n* Obesity (Body Mass Index \\> 35 kg\u002Fm²)","FEMALE","18 Years","65 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to evaluate whether the Trendelenburg position affects electroencephalography-based depth of anesthesia monitoring and cerebral oxygenation during general anesthesia.\n\nThe main questions it aims to answer are:\n\n* Does the Trendelenburg position cause a change in the Patient State Index (PSI), an Electroensephalography (EEG)-derived indicator of anesthetic depth?\n* Are changes in PSI associated with changes in frontal cerebral oxygen saturation (rSO₂) and hemodynamic parameters?\n\nThe study will include adult female patients undergoing elective laparoscopic gynecologic surgery under general anesthesia.\n\nParticipants will receive standard anesthesia and routine intraoperative monitoring. In addition to standard monitoring, Patient State Index (PSI) and frontal cerebral oxygen saturation (rSO₂) will be recorded using non-invasive sensors. No additional intervention will be performed for research purposes.\n\nPhysiological parameters including PSI, cerebral oxygen saturation, mean arterial pressure, heart rate, oxygen saturation, and end-tidal carbon dioxide will be recorded at predefined intraoperative time points before and after the Trendelenburg position.\n\nThe study aims to determine whether position-related physiological changes influence EEG-based anesthesia depth indices and to improve the interpretation of intraoperative brain monitoring.",[25],"Laparoscopic Hysterectomy",[27,28,29,30,31,32,33,34],"Trendelenburg Position","Patient State Index","Processed EEG","Depth of Anesthesia Monitoring","Cerebral Oxygenation","Near-Infrared Spectroscopy","General Anesthesia","Intraoperative Monitoring","RECRUITING","2026-06-02",{"date":38,"type":39},"2026-06-04","ACTUAL",{"date":41,"type":39},"2026-05-01",{"date":43,"type":21},"2026-12-01",{"name":45,"class":46},"Sakarya University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100639846","total-laparoscopic-hysterectomy-with-prior-uterine-artery-cauterization-from-the-origin-versus-conventional-laparoscopic-hysterectomy-100639846","NCT07601971","Total Laparoscopic Hysterectomy With Prior Uterine Artery Cauterization From the Origin Versus Conventional Laparoscopic Hysterectomy","Inclusion Criteria: Age of the patient is more than 35 y . Non malignant pathologies including fibroids, endometrial hyperplasia, Dysfunctional Uterine bleeding not responding to medical treatment.\n\nGood general condition of the patient ( American society of Anesthesiologists \"ASA\" score 1 , 2 , 3 ( Horvath et al ,. 2021) .\n\nUterine size is less than 20 weeks by fundal level . -\n\nExclusion Criteria:Age of the patient is less than 35 y . Gynecological malignancies . Contraindications for laparoscopy as any medical condition worsens by peumo peritoneum or Trendelenburg position as severely compromised cardiopulmonary status .\n\nPatients with American society of Anesthesiologists score 4 or more . ( Horvath et al ,. 2021) Uterine size is more than 20 weeks by fundal level .\n\n\\-","35 Years","55 Years",{"count":57,"type":21},44,"INTERVENTIONAL",[60],"NA","The main goal of this study is to compare between total Laparoscopic hysterectomy proceeded by Uterine artery cauterization at its origin and conventional total Laparoscopic hysterectomy regarding: bleeding , operative time , intra operative time and follow up post operative.",[25],"NOT_YET_RECRUITING","2026-05-15",{"date":66,"type":39},"2026-05-22",{"date":64,"type":21},{"date":69,"type":21},"2027-06-15",{"name":71,"class":46},"Kafrelsheikh University",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":79,"targetDuration":4,"studyType":58,"phases":80,"briefSummary":81,"conditions":82,"keywords":87,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100640445","intertransverse-process-block-versus-m-tapa-block-after-laparoscopic-hysterectomy-100640445","NCT07599787","Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Hysterectomy","Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Hysterectomy: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 18-65 years\n* ASA physical status I-III\n* Scheduled for elective laparoscopic hysterectomy\n* Body mass index (BMI) 18-35 kg\u002Fm²\n* Ability to understand and use the patient-controlled analgesia (PCA) device\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate\n* Allergy to local anesthetics\n* Infection at the injection site\n* Coagulopathy or ongoing anticoagulant therapy\n* Chronic opioid use or opioid dependence\n* Severe hepatic or renal insufficiency\n* Pregnancy or breastfeeding\n* Cognitive impairment or inability to communicate pain scores\n* Body mass index (BMI) \\>35 kg\u002Fm²",{"count":20,"type":21},[60],"This randomized clinical trial aims to evaluate and compare the analgesicefficacy of the Intertransverse Process Block (ITPB) and the Modified Thoracoabdominal Nerve Block through Perichondrial Approach (M-TAPA) in patients undergoing laparoscopic hysterectomy. The primary outcome is the Visual Analog Scale (VAS) score within the first 24 hours after surgery. Secondary outcomes include total opioid consumption, requirement for rescue analgesia, block- related complications and adverse effects (hematoma, pneumothorax, local anesthetic systemic complications, vascular puncture, and infection), patient satisfaction assessed using a Likert scale, quality of recovery assessed using the QoR-15 questionnaire, and incidence of postoperative nausea and vomiting.",[83,84,25,85,86],"Intertransverse Process Block","Mtapa Block","Postoperative Pain","Regional Anaesthesia",[88,89],"M-TAPA","ITP",{"date":91,"type":39},"2026-05-20",{"date":93,"type":21},"2026-11-18",{"date":95,"type":21},"2027-11-30",{"name":97,"class":46},"Antalya City Hospital",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":105,"maxAge":18,"enrollmentInfo":106,"targetDuration":4,"studyType":58,"phases":108,"briefSummary":110,"conditions":111,"keywords":114,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":47},"100600727","phase-4-preoperative-acetazolamide-100600727","NCT07101250","Preoperative Acetazolamide","Preoperative Acetazolamide for Improved Pain Control Following Laparoscopic Hysterectomy","Inclusion Criteria:\n\n* Women\n* Ages 21-65\n* undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without bilateral salpingoophorectomy\n* undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without cystoscopy\n\nExclusion Criteria:\n\n* Allergy to acetazolamide or sulfonamides\n* Known electrolyte disturbances\n* Pregnancy\n* Kidney failure or creatinine \\>1.5\n* Diuretic or lithium use\n* Chronic obstructive pulmonary disease (COPD) or other lung disease\n* Central nervous system disorders\n* Liver disease\n* Glaucoma\n* Preoperative or chronic opioid use\n* Diagnosis of fibromyalgia\n* Preoperative shoulder pain\n* Conversion to laparotomy\n* Intraoperative bladder or bowel injury\n* Inability to understand or utilize visual analog scale\n* Undergoing concurrent reconstructive procedures","21 Years",{"count":107,"type":21},100,[109],"PHASE4","The goal of this randomized study looks at whether giving patients a medicine called acetazolamide (also called Diamox) before they have laparoscopic hysterectomy may decrease postoperative pain. Researchers will compare acetazolamide to a placebo or inactive drug, to see if acetazolamide helps the pain that may occur after surgery from the gas used in the abdomen during the laparoscopic procedure. Patients will be asked to rate their pain before surgery and after surgery through 24 hours.",[112,25,113],"Post Operative Pain","Referred Pain",[115,116,117],"shoulder pain","laparoscopic","analgesia","2026-02-18",{"date":120,"type":39},"2026-02-20",{"date":122,"type":39},"2025-10-30",{"date":124,"type":21},"2026-11-01",{"name":126,"class":46},"Prisma Health-Upstate",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":135,"targetDuration":4,"studyType":58,"phases":137,"briefSummary":138,"conditions":139,"keywords":142,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":157,"locationsCount":47},"100610786","intrathecal-morphine-versus-trocar-site-and-intraperitoneal-bupivacaine-for-quality-of-recovery-after-laparoscopic-hysterectomy-100610786","NCT07232108","Intrathecal Morphine Versus Trocar-Site and Intraperitoneal Bupivacaine for Quality of Recovery After Laparoscopic Hysterectomy","Effects of Intrathecal Morphine Compared With Trocar-Site Infiltration and Intraperitoneal Bupivacaine on Postoperative Quality of Recovery and Inflammatory Markers After Laparoscopic Hysterectomy: A Prospective, Randomized, Double-Blind Controlled Trial","ITM-LH-QoR","Inclusion Criteria:\n\n* Female patients aged 18-65 years.\n* Elective laparoscopic hysterectomy planned for benign gynecological conditions.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Coagulopathy or bleeding disorders.\n* Opioid dependence or chronic opioid use.\n* Allergy or contraindication to local anesthetics or morphine.\n* Contraindication to neuraxial (spinal) anesthesia.\n* History of chronic pain syndromes.\n* Severe renal or hepatic dysfunction.\n* Pregnancy or breastfeeding.",{"count":136,"type":21},64,[60],"This study aims to compare the effects of intrathecal morphine with trocar-site infiltration and intraperitoneal bupivacaine on postoperative pain control, quality of recovery, and inflammatory response in patients undergoing elective laparoscopic hysterectomy. Laparoscopic hysterectomy is widely used for benign gynecologic conditions, but postoperative pain may result from trocar-site trauma, peritoneal irritation, and carbon dioxide insufflation. Effective postoperative analgesia can improve patient comfort, reduce opioid use, and enhance early recovery.\n\nIntrathecal morphine is known to provide potent early postoperative analgesia but may cause side effects such as nausea, vomiting, pruritus, and respiratory depression. Local anesthetic techniques, including trocar-site infiltration and intraperitoneal bupivacaine, have also been shown to reduce postoperative pain after minimally invasive gynecologic surgery.\n\nIn this prospective, randomized, double-blind study, patients will be assigned to one of two groups:\n\nIntrathecal morphine (ITM) administered before induction of anesthesia;\n\nLocal anesthesia group (LA) receiving trocar-site infiltration and intraperitoneal bupivacaine at the end of surgery.\n\nThe primary outcome is the Quality of Recovery-15 (QoR-15) score at 24 hours. Secondary outcomes include pain scores, opioid consumption, time to first rescue analgesia, postoperative nausea and vomiting, pruritus, respiratory depression, early mobilization, bowel function recovery, and perioperative inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII).\n\nThe results of this trial are expected to guide clinicians in selecting optimal analgesic strategies for laparoscopic hysterectomy and to contribute to improved patient recovery and postoperative satisfaction.",[140,25,141],"Postoperative Pain Management","Postoperative Recovery",[143,144,145,25,146,85,147,148,149,150],"Intrathecal Morphine","Trocar-Site Infiltration","Intraperitoneal Bupivacaine","Quality of Recovery (QoR-15)","Opioid Consumption","Inflammatory Markers","Neutrophil-to-Lymphocyte Ratio (NLR)","Systemic Immune-Inflammation Index (SII)","2025-12-02",{"date":153,"type":39},"2025-12-08",{"date":155,"type":39},"2025-12-01",{"date":36,"type":21},{"name":158,"class":46},"Ataturk University",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":18,"enrollmentInfo":167,"targetDuration":4,"studyType":58,"phases":169,"briefSummary":170,"conditions":171,"keywords":172,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":180,"leadSponsor":182,"locationsCount":47},"100610345","endoscopic-tissue-cutting-and-abdominal-extraction-device-vs-conventional-cold-scalpel-100610345","NCT07226375","Endoscopic Tissue Cutting and Abdominal Extraction Device vs. Conventional Cold Scalpel","Comparison of Endoscopic Tissue Cutting and Abdominal Extraction Device With Conventional Cold Scalpel","SOLENDO-1","Inclusion Criteria:\n\n* Planned laparoscopic hysterectomy\n* Estimated uterine weight of 500 g or more\n\nExclusion Criteria:\n\n* Sexual inactivity",{"count":168,"type":21},84,[60],"The aim of the study is to compare the surgical tissue removal success of the endoscopic tissue cutting device, which was designed by the conductor and developed with the support of TUBITAK-1512 project and for which Turkish and European patent applications were made, with the conventional cold scalpel. Laparoscopic surgeries are performed through incisions ranging from 0.5 cm to 1 cm. After the operation, much larger masses need to be removed from the abdomen compared to these incisions. Currently, in laparoscopic surgery, masses are removed from the abdomen by cutting them into pieces with a scalpel, using electrical devices called power morcellators that are used to cut the tissue\u002Fmass with rotational movement and remove it from the abdomen, and directly removing the mass from the abdomen through an incision made as large as the size of the mass. Trying to remove large tissues\u002Fmass by dissecting them with a scalpel through incisions that are 1.5-2 cm wide and limit the surgeon's range of motion is quite laborious, tiring, time-consuming and risky. In the use of Power Morcellator disintegrator devices, there is a risk of the pieces of the mass spreading into the abdomen while cutting and separating the tissue\u002Fmass that is being removed into small pieces due to the rotational movement in the working principle. In operations where the Power Morcellator device is used, if the removed tissue is malignant (cancerous), the patient faces the risk of metastasis spreading to the entire abdomen. Due to these risks, the use of power morcellator devices has been completely banned in the United States, and in European Union countries, it has been required that the device be operated in protective bags. The invention is a medical device that will allow large masses to be removed quickly, safely and easily through small incisions in closed surgeries. The device offers an effective solution to the problems of the current technique.\n\nWithin the scope of the study, the morcellator scissors and the scalpel, which are designed and started to be mass-produced, will be compared in the morcellation (removal by separating into pieces) process to be performed during the removal of the mass from the vagina after laparoscopic hysterectomy surgeries, and the morcellation time, possible complications and the possible effects of the device to be used on the case will be investigated.",[25],[173,174,175],"laparoscopic hysterectomy","morcellation","tissue extraction","2025-11-13",{"date":178,"type":39},"2025-11-14",{"date":176,"type":39},{"date":181,"type":21},"2026-12-17",{"name":183,"class":46},"Ege University",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":191,"targetDuration":4,"studyType":58,"phases":193,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":47},"100597736","sevoflurane-with-or-without-intravenous-lidocaine-infusion-versus-propofol-anesthesia-on-intracranial-pressure-and-cerebral-oxygenation-during-laparoscopic-hysterectomy-100597736","NCT07062367","Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy","Effect of Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy: A Randomized Controlled Study","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* American Society of Anesthesiologists (ASA) physical status I and Ⅱ.\n* Body mass index (BMI) ≤35.\n* Females scheduled for laparoscopic hysterectomy.\n\nExclusion Criteria:\n\n* Patients' refusal to participate in the study.\n* Hypersensitivity and allergy to drugs of the study.\n* Contraindication for optic nerve sheath diameter assessment. E.g., patient with pre-existing ophthalmic diseases, a history of ophthalmic surgery\n* Any central nervous system or cardiovascular disease, severe hepatic or renal impairment\n* Intraoperative circumstances, such as inability to perform optic nerve sheath diameter or conversion to open surgery\n* If peak inspiratory pressure (PIP) exceeds 35.",{"count":192,"type":21},90,[60],"This study will be conducted to evaluate the effects of different anesthetic modalities \\[sevoflurane with or without intraoperative lidocaine infusion and Propofol total intravenous anesthesia (TIVA)\\] on intracranial pressure (ICP) and cerebral oxygenation assessed by non-invasive methods during laparoscopic hysterectomy (LH).",[196,197,198,199,31,25],"Sevoflurane","Lidocaine","Propofol","Intracranial Pressure","2025-07-02",{"date":202,"type":39},"2025-07-14",{"date":204,"type":39},"2025-02-01",{"date":206,"type":21},"2027-02-01",{"name":208,"class":46},"Tanta University",{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":4,"eligibilityCriteria":215,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":58,"phases":218,"briefSummary":219,"conditions":220,"keywords":222,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":234},"100565474","evaluation-and-comparison-between-general-anesthesia-vs-two-types-of-combined-anesthesia-for-opioid-consumption-in-laparoscopic-hysterectomy-100565474","NCT06642649","Evaluation and Comparison Between General Anesthesia VS Two Types of Combined Anesthesia for Opioid Consumption in Laparoscopic Hysterectomy","Evaluation and Comparison Between General Anesthesia VS Two Types of Combined Anesthesia (general and Spinal Anesthesia) for Opioid Consumption in Laparoscopic Hysterectomy: a Multi-Center, Randomized, Prospective, Controlled Trial","Inclusion Criteria:\n\n* patients over 18 year of age,\n* ASA physical status I to III scheduled for laparoscopic hysterectomy (with or without adnexectomy)\n\nExclusion Criteria:\n\n* patients with inability to consent,\n* patient refusal,\n* contraindication to spinal anesthesia (e.g., hemodynamic instability, infection at the surgery site, and neurologic defects such as transverse myelitis, coagulopathies or ongoing anticoagulant therapy),\n* known chronic pain syndrome, known\n* suspected non- compliance,\n* drug, or alcohol abuse ,\n* major oncological surgeries,\n* allergy to drugs used in the protocol,\n* previous chronic use of analgesics\n* history of opioid abuse",{"count":217,"type":21},45,[60],"The aim of the study is to evaluate and compare general anesthesia VS two types of combined anesthesia in opioid consumption after laparoscopic hysterectomy",[25,221],"Gynecology",[173,223,224],"spinal anesthesia","general anesthesia","2025-02-26",{"date":227,"type":39},"2025-02-28",{"date":229,"type":39},"2024-11-01",{"date":231,"type":21},"2026-04-30",{"name":233,"class":46},"Andrea Saporito",2,{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":241,"eligibilityCriteria":242,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":243,"targetDuration":4,"studyType":58,"phases":244,"briefSummary":245,"conditions":246,"keywords":247,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":47},"100569135","phase-4-oxycodone-versus-sufentanil-in-patient-controlled-intravenous-analgesia-after-laparoscopic-hysterectomy-100569135","NCT06690307","Oxycodone Versus Sufentanil in Patient-controlled Intravenous Analgesia After Laparoscopic Hysterectomy","The Efficacy and Safety of Oxycodone in Patient-controlled Intravenous Analgesia After Laparoscopic Hysterectomy","Oxycodone","Inclusion Criteria:\n\n* selective laparoscopic hysterectomy\n* general anesthesia\n* ASA classification I - III\n* aged 18 - 65 years\n\nExclusion Criteria:\n\n* allergy to oxycodone or any other drugs will be used in the study\n* preoperative opioids medication\n* opioids abuse\n* hepatic or renal dysfunction\n* cardiovascular or pulmonary dysfunction\n* lack of full civil capacity or refuse to participate",{"count":136,"type":21},[109],"This study is designed to evaluate the efficacy and safety of hydrocodone in patient-controlled intravenous analgesia (PCIA) during gynecological laparoscopy, thus to explore suitable PCIA scheme to optimize postoperative pain management for patients undergoing gynecological laparoscopic surgeries.",[25],[248,249,173],"oxycodone","patient-controlled intravenous analgesia","2024-12-02",{"date":252,"type":39},"2024-12-04",{"date":254,"type":39},"2024-12-03",{"date":256,"type":21},"2026-07-31",{"name":258,"class":46},"Affiliated Hospital of Nantong University",{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":4,"eligibilityCriteria":265,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":266,"targetDuration":4,"studyType":58,"phases":268,"briefSummary":269,"conditions":270,"keywords":273,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":47},"100570628","phase-4-impact-of-preoperative-quadratus-lumborum-block-on-postoperative-opioid-consumption-after-laparoscopic-hysterectomy-100570628","NCT06709716","Impact of Preoperative Quadratus Lumborum Block on Postoperative Opioid Consumption After Laparoscopic Hysterectomy","Impact of Preoperative Quadratus Lumborum Block on Postoperative Opioid Consumption After Laparoscopic Hysterectomy: a Double-blinded Randomized Controlled Trial","Inclusion Criteria:\n\n* 18 years or older\n* scheduled to undergo laparoscopic hysterectomy\n* able to speak and understand English\n* DEERs eligible (eligible for healthcare within military heath system)\n* Owning a phone that can receive text messages or having internet access to complete questionnaires\n\nExclusion Criteria:\n\n* pre-operative opioid use\n* pre-operative pain management clinic patient\n* planned concomitant prolapse or incontinence procedure\n* planned concomitant non-gynecologic abdominal procedure (i.e. hernia repair)\n* inability to receive liposomal or non-liposomal bupivacaine\n* inability to receive non-steroidal anti-inflammatory drugs (NSAIDs)\n* inability to receive acetaminophen\n* inability to receive oxycodone\n* QL block not able to be performed bilaterally\n* planned or performed mini-laparotomy (incision greater than 2cm)\n* case converted to laparotomy",{"count":267,"type":21},76,[109],"The goal of this clinical trial is to learn if preoperative nerve block (quadratus lumborum \\[QL\\] block) works to improve pain control during and after laparoscopic hysterectomy. The main questions it aims to answer are:\n\nDoes QL block decrease the amount of narcotic medication needed during surgery? Does QL block decrease the amount of narcotic medication needed after surgery?\n\nResearchers will compare QL block to local injection of a numbing medication at each incision site (the current standard practice) to see if QL block works to decrease surgical pain.\n\nParticipants will be randomly assigned to receive one of the two following interventions:\n\n1. QL block before surgery with a long-acting numbing medicine (liposomal bupivacaine) and then injection of placebo (saline) at each incision site in the operating room.\n2. QL block before surgery with placebo (saline) and then injection of local numbing medicine (bupivacaine) at each incision site in the operating room.\n\nParticipants will also:\n\n* Visit the clinic\u002Fhospital for a pre-operative appointment, the surgical procedure, and a 4-6 week post-operative appointment (all standard visits even if not participating in research)\n* Complete a questionnaire electronically, or by phone, that takes \\\u003C10 minutes at the pre-operative appointment and on postoperative days 1, 3, 5, 14, and 4-6 weeks.",[85,25,271,272],"Nerve Block","Quadratus Lumborum Block",[274,275,173],"postoperative pain","quadratus lumborum block","2024-11-25",{"date":278,"type":39},"2024-11-29",{"date":280,"type":21},"2024-12-01",{"date":282,"type":21},"2026-02",{"name":284,"class":285},"Walter Reed National Military Medical Center","FED",{"id":287,"slug":288,"hasResults":11,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":294,"sex":16,"minAge":295,"maxAge":4,"enrollmentInfo":296,"targetDuration":4,"studyType":58,"phases":298,"briefSummary":299,"conditions":300,"keywords":307,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":320,"leadSponsor":322,"locationsCount":4},"100519946","evaluating-artisential-laparoscopic-instruments-in-gynecologic-surgery-100519946","NCT06050161","Evaluating Artisential Laparoscopic Instruments in Gynecologic Surgery","Minimally Invasive Gynecologic Surgery Utilizing the Artisential Articulating Laparoscopic Instruments","MIGS-ART","Inclusion Criteria:\n\n* Patient scheduled for robotic or laparoscopic total hysterectomy\n* Patient scheduled for robotic or laparoscopic sacrocolpopexy\n\nExclusion Criteria:\n\n* Not a candidate for the above surgical procedures",true,"22 Years",{"count":297,"type":21},50,[60],"This study evaluates the efficacy and safety of Artisential laparoscopic instruments in minimally invasive gynecologic surgery.",[301,302,303,304,305,25,306],"Pelvic Organ Prolapse","Abnormal Uterine Bleeding","Mesh Augmentation","Laparoscopic Surgery","Robotic Surgical Suturing","Minimally Invasive Surgery",[308,309,310,311,312,313,314],"Laparoscopic surgery","Laparoscopic suturing","Laparoscopic instruments","Pelvic organ prolapse","Sacrocolpopexy","Minimally invasive surgery","Vaginal cuff closure","2023-09-17",{"date":317,"type":39},"2023-09-22",{"date":319,"type":21},"2023-09-20",{"date":321,"type":21},"2027-09-20",{"name":323,"class":46},"Kern Medical Center"]