[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"laparoscopic-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:laparoscopic-surgery":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,50,76,95,118,142,171,201,237,259,277,292,322,349,378,402,426,456,479,509,530,550,575,609,634],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100641974","pre-incisional-infiltration-with-ropivacaine-plus-triamcinolone-for-relieving-postoperative-pain-after-laparoscopic-surgery-100641974",false,"NCT07591233","Pre-incisional Infiltration With Ropivacaine Plus Triamcinolone for Relieving Postoperative Pain After Laparoscopic Surgery","The Efficacy and Safety of Pre-incisional Infiltration With Ropivacaine Plus Triamcinolone for Postoperative Pain in Patients Undergoing Laparoscopic Surgery: a Multi-center Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Patients scheduled for elective Laparoscopic Surgery for laparoscopic cholecystectomy, appendectomy, or hernia repair under general anesthesia;\n2. Ages 18 to 64 years old;\n3. American Society of Anesthesiologists (ASA) physical status of I-III;\n4. Patients must be able to understand nature and potential personal; consequences of the clinical trial and cooperation with follow-up investigations\n5. signing of the informed consent form.\n\nExclusion Criteria:\n\n1. History of allergies to experimental drugs such as opioids or steroids;\n2. Alcohol abuse; Long term use of opioid drugs (exceeding 2 weeks or 3 days per week for more than 1 month); Suspected use of sedatives and analgesics; Use analgesic drugs within 24 hours before surgery; Patients undergoing steroid therapy;\n3. Serious neurological disorders, severe liver and kidney dysfunction, heart failure, etc;\n4. Unable to use pain assessment scale;\n5. Pregnant or lactating patients.","ALL","18 Years","64 Years",{"count":21,"type":22},150,"ESTIMATED","INTERVENTIONAL",[25],"NA","Incisional infiltration is the simplest, safest, and most effective anesthesia method for preventing incision pain after laparoscopic surgery, but even using long-acting local anesthetics, the effectiveness of postoperative analgesia can only last for a relatively short period of time. Studies have shown that up to 80% of patients experience postoperative pain following laparoscopic surgery due to inflammation caused by surgical incisions and surrounding tissues, necessitating pharmacological relief. Inflammatory mediators released from the soft tissues around laparoscopic incisions not only significantly alters the chemical microenvironment at the peripheral terminals of nociceptors, directly inducing pain, but also sensitizes afferent fibers, contributing to peripheral sensitization. Preemptive incisional infiltration using local anesthetics with corticosteroids which have potent local anti-inflammatory properties may play a key role in preventing or reducing postoperative pain. The objective of this trial is to determine whether preemptive incisional infiltration with ropivacaine plus triamcinolone is superior to ropivacaine alone in relieving postoperative pain for adults undergoing laparoscopic surgery. We also compare the effects of the two intervention measures on postoperative pain management, patient safety, and recovery quality.",[28,29,30,31],"Laparoscopic Surgery","Laparoscopic Cholecystectomy","Appendectomy, Laparoscopic","Hernia Repair",[33,34,35,36],"Laparoscopic","Incisional infiltration","triamcinolone","postoperative pain","RECRUITING","2026-06-16",{"date":40,"type":41},"2026-06-17","ACTUAL",{"date":43,"type":41},"2026-06-01",{"date":45,"type":22},"2028-05-30",{"name":47,"class":48},"Beijing Tiantan Hospital","OTHER",1,{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":69,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100642290","transnasal-microstream-etco2-reduces-hypoxemia-during-emergence-in-aged-post-abdomen-surgery-100642290","NCT07652385","Transnasal Microstream EtCO2 Reduces Hypoxemia During Emergence in Aged Post-Abdomen Surgery","Effect of Transnasal Microstream Capnography on Incidence of Hypoxemia During Emergence From General Anesthesia in Elderly Patients After Abdominal Surgery: A Prospective Randomised Controlled Trial","Inclusion Criteria:\n\n* Age 65-80 years;\n* ASA physical status I-III;\n* BMI 18-30 kg\u002Fm²;\n* Participants scheduled for elective laparoscopic surgery under general anesthesia with endotracheal intubation;\n* Willing to participate in the study and provide written informed consent\n\nExclusion Criteria:\n\n* Patients with nasal bleeding, nasal mucosal injury, nasal cavity occupancy, or other conditions that preclude transnasal carbon dioxide monitoring;\n* Patients undergoing emergency surgery;\n* Participants requiring postoperative assisted ventilation via endotracheal intubation or tracheostomy;\n* Presence of any disease or condition that may cause abnormal end-tidal carbon dioxide waveforms or abnormal baseline pulse oximetry (e.g., congenital heart disease or chronic lung disease);\n* Severe cardiac insufficiency (≤4 Metabolic Equivalents \\[MetS\\]);\n* Severe renal insufficiency (acute kidney injury \\[AKI\\] or chronic kidney disease \\[CKD\\] stage 4 or higher);\n* Severe hepatic insufficiency (Child-Pugh class C or worse);\n* Allergy to study medications;\n* Daily alcohol intake ≥60 grams;\n* History of psychiatric disorders such as depression, severe central nervous system depression, Parkinson's disease, basal ganglion lesions, schizophrenia, epilepsy, Alzheimer's disease;\n* Participation in another related clinical study within the past 3 months.",true,"65 Years","80 Years",{"count":61,"type":22},324,[25],"This prospective, randomized controlled study aims to investigate whether transnasal microstream end-tidal carbon dioxide (EtCO₂) monitoring in the post-anesthesia care unit (PACU) reduces the incidence of postoperative hypoxemia in elderly patients (65-80 years, ASA I-III, BMI 18-30 kg\u002Fm²) undergoing elective laparoscopic surgery under general anesthesia with endotracheal intubation. A total of 324 patients will be randomized 1:1 to either the control group (standard SpO₂ monitoring and clinical observation with oxygen delivery at 2 L\u002Fmin via sampling line) or the experimental group (same oxygen delivery plus continuous real-time transnasal microstream EtCO₂ monitoring). The primary outcome is the incidence of hypoxemia (SpO₂ \\\u003C 90% for \\>15 seconds) after extubation in the PACU. Secondary outcomes include severe hypoxemia (SpO₂ \\\u003C 85%), lowest SpO₂ during PACU stay, vital signs at specified time points, PACU length of stay, and other adverse events. Statistical analysis will use chi-square or Fisher's exact test for the primary outcome, with a sample size calculated to detect a reduction in hypoxemia from 33% (control) to 18% (experimental group) (α=0.05, power=80%, plus 20% dropout).",[65,28,66,67],"Elderly Patients","Postoperative Hypoxemia","Capnography","NOT_YET_RECRUITING",{"date":40,"type":41},{"date":71,"type":22},"2026-07-01",{"date":73,"type":22},"2028-10-01",{"name":75,"class":48},"Jianbo Wu",{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":90,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":94,"locationsCount":49},"100641734","pre-incisional-infiltration-with-ropivacaine-plus-diprospan-for-relieving-postoperative-pain-after-laparoscopic-surgery-100641734","NCT07626463","Pre-incisional Infiltration With Ropivacaine Plus Diprospan for Relieving Postoperative Pain After Laparoscopic Surgery","The Efficacy and Safety of Pre-incisional Infiltration With Ropivacaine Plus Diprospan in Patients Undergoing Laparoscopic Surgery: a Multi-center Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Patients scheduled for elective Laparoscopic Surgery for laparoscopic cholecystectomy, appendectomy, or hernia repair under general anesthesia;\n2. Ages 18 to 64 years old;\n3. American Society of Anesthesiologists (ASA) physical status of I-III;\n4. Patients must be able to understand nature and potential personal; consequences of the clinical trial and cooperation with follow-up investigations;\n5. signing of the informed consent form.\n\nExclusion Criteria:\n\n1. History of allergies to experimental drugs such as opioids or steroids;\n2. Alcohol abuse; Long term use of opioid drugs (exceeding 2 weeks or 3 days per week for more than 1 month); Suspected use of sedatives and analgesics;\n3. Use analgesic drugs within 24 hours before surgery;\n4. Patients undergoing steroid therapy;\n5. Serious neurological disorders, severe liver and kidney dysfunction, heart failure, etc;\n6. Unable to use pain assessment scale;\n7. Pregnant or lactating patients.",{"count":21,"type":22},[25],"Incisional infiltration is the simplest, safest, and most effective anesthesia method for preventing incision pain after laparoscopic surgery, but even using long-acting local anesthetics, the effectiveness of postoperative analgesia can only last for a relatively short period of time. Studies have shown that up to 80% of patients experience postoperative pain following laparoscopic surgery due to inflammation caused by surgical incisions and surrounding tissues, necessitating pharmacological relief. Inflammatory mediators released from the soft tissues around laparoscopic incisions not only significantly alters the chemical microenvironment at the peripheral terminals of nociceptors, directly inducing pain, but also sensitizes afferent fibers, contributing to peripheral sensitization.\n\nNumerous studies have shown that glucocorticoids not only can achieve anti-inflammatory and analgesic effects by inhibiting inflammatory cytokines and inflammatory responses but also can prolong the duration of action of local anesthetics. Preemptive incisional infiltration using local anesthetics with corticosteroids which have potent local anti-inflammatory properties may play a key role in preventing or reducing postoperative pain. The objective of this trial is to determine whether preemptive incisional infiltration with ropivacaine plus diprospan is superior to ropivacaine alone in relieving postoperative pain for adults undergoing laparoscopic surgery. The investigators also compare the effects of the two intervention measures on postoperative pain management, patient safety, and recovery quality.",[28,87,29,88,89],"Laparoscopic Appendectomy","Laparoscopic Hernia Repair Surgery","Infiltration Anesthesia",{"date":40,"type":41},{"date":92,"type":22},"2026-05-30",{"date":45,"type":22},{"name":47,"class":48},{"id":96,"slug":97,"hasResults":12,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":57,"sex":102,"minAge":18,"maxAge":58,"enrollmentInfo":103,"targetDuration":4,"studyType":23,"phases":104,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":49},"100643680","maneuvers-to-reduce-laparoscopic-pain-100643680","NCT07583433","Maneuvers to Reduce Laparoscopic Pain","Optimal Maneuver to Reduce Postoperative Pain Following Elective Laparoscopic Surgeries","Inclusion Criteria:\n\n* Patients age 18 to 65\n* Benign, elective laparoscopic surgeries\n\nExclusion Criteria:\n\n* Ages \\\u003C18 and age \\>65\n* Emergency or urgent surgeries\n* Surgeries for chronic pelvic pain, malignancy\n* Surgeries during pregnancy\n* Severe cardiopulmonary disease\n* Prior extensive abdominal surgeries (more than 2 abdominal or pelvic surgeries)\n* Inability to consent","FEMALE",{"count":21,"type":22},[25],"Laparoscopic surgery has revolutionized surgical care by reducing morbidity and improving post operative recovery. Laparoscopic surgery involves the use of carbon dioxide for insufflation to achieve optimal visualization. There is literature that demonstrates higher insufflation pressures being associated with increased postoperative pain - particularly shoulder pain - and opioid use. The ideal amount of intraperitoneal pressure is still under debate as other studies demonstrate that reduced pneumoperitoneum insufflation has also shown to negatively impact surgeon satisfaction and trended with longer operative time and greater blood loss without impacting pain.\n\nResidual intraperitoneal carbon dioxide can also contribute to postoperative discomfort. Studies have shown the effectiveness of various maneuvers in removing residual gas to reduce postoperative pain, such as intraperitoneal saline instillation, pulmonary recruitment, and gas aspiration via smoke evacuator.\n\nDespite these advantages, there is a lack of a clear consensus on the optimal method for reducing residual intraperitoneal gas. Conversely, literature has mixed results regarding the true significance in pain reduction.\n\nGiven the importance of minimizing postoperative pain, reducing opioid requirements, and shortening postoperative recovery time, the investigators propose a prospective, patient-blinded, randomized controlled trial. The investigators aim to investigate whether active gas removal via a smoke evacuator, multiple breath recruitment maneuvers, or no intervention would contribute to lowest postoperative pain. The findings will help identify the most effective method for reducing residual pneumoperitoneum-related pain and thus inform surgical practices and improve patient outcomes.",[28,107,108],"Post Operative Pain, Acute","Pneumoperitoneum","2026-06-05",{"date":111,"type":41},"2026-06-09",{"date":113,"type":22},"2026-07-10",{"date":115,"type":22},"2028-11",{"name":117,"class":48},"Henry Ford Health System",{"id":119,"slug":120,"hasResults":12,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":12,"sex":17,"minAge":125,"maxAge":59,"enrollmentInfo":126,"targetDuration":4,"studyType":23,"phases":128,"briefSummary":129,"conditions":130,"keywords":131,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":49},"100640236","response-surface-modeling-of-remimazolam-and-sevoflurane-100640236","NCT07620782","Response Surface Modeling of Remimazolam and Sevoflurane","Response Surface Model Between Remimazolam and Sevoflurane; Comparison of the Minto and the Greco Model","Inclusion Criteria:\n\n* Adults aged 20 to 80 years\n* Scheduled for elective surgery under general anesthesia at Pusan National University Yangsan Hospital\n* American Society of Anesthesiologists (ASA) physical status I or II\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy to remimazolam or sevoflurane\n* Renal, hepatic, neuromuscular, or neurological disease\n* Use of medications affecting the central nervous system\n* Chronic psychoactive drug use\n* Ischemic heart disease\n* Pregnant women","20 Years",{"count":127,"type":22},80,[25],"This prospective randomized open-label study aims to investigate the pharmacodynamic interaction between remimazolam and sevoflurane during general anesthesia using response surface modeling. Although remimazolam has favorable hemodynamic stability compared with propofol, its hypnotic effect may be less predictable and poorly correlated with conventional sedation monitoring indices such as the bispectral index (BIS). In clinical practice, remimazolam and sevoflurane are often combined during induction and maintenance of anesthesia; however, the optimal interaction between these agents remains unclear.\n\nThis study will evaluate whether the interaction between remimazolam and sevoflurane is synergistic, additive, or infra-additive using two representative response surface interaction models: the Minto model and the Greco model. BIS values and predicted effect-site concentrations will be analyzed using NONMEM software.",[28],[132],"general anesthesia","2026-05-27",{"date":135,"type":41},"2026-06-02",{"date":137,"type":41},"2026-05-15",{"date":139,"type":22},"2027-12-31",{"name":141,"class":48},"Pusan National University Yangsan Hospital",{"id":143,"slug":144,"hasResults":12,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":23,"phases":152,"briefSummary":153,"conditions":154,"keywords":157,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":49},"100640180","superior-hypogastric-plexus-block-during-laparoscopic-colorectal-cancer-surgery-100640180","NCT07579780","Superior HypogastrIc plExus bLock During Laparoscopic Colorectal Cancer Surgery","Superior Hypogastric Plexus Block for Early Recovery After Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trial","SHIELDS","Inclusion Criteria:\n\n* Able to provide informed consent.\n* Undergoing elective laparoscopic radical resection for colorectal cancer.\n* American Society of Anesthesiologists Physical Status (ASA) class I-III.\n\nExclusion Criteria:\n\n* Allergy to block medication (s).\n* Coagulation dysfunction.\n* Local or systemic infection.\n* Unable to cooperate with the completion of the study protocol.",{"count":151,"type":22},170,[25],"This trial seeks to assess the efficacy of a superior hypogastric plexus block for early quality of recovery after laparoscopic colorectal cancer surgery.",[155,28,156],"Colorectal Cancer (Diagnosis)","Superior Hypogastric Plexus Block",[158,159,160,161],"Colorectal Cancer","laparoscopic surgery","superior hypogastric plexus block","Quality of recovery","2026-05-05",{"date":164,"type":41},"2026-05-12",{"date":166,"type":41},"2025-12-15",{"date":168,"type":22},"2027-02-18",{"name":170,"class":48},"Sixth Affiliated Hospital, Sun Yat-sen University",{"id":172,"slug":173,"hasResults":12,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":23,"phases":181,"briefSummary":183,"conditions":184,"keywords":188,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":49},"100633384","phase-4-anrikefon-based-patient-controlled-intravenous-analgesia-following-laparoscopic-surgery-100633384","NCT07525986","Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery","Efficacy of Anrikefon-based Patient-controlled Intravenous Analgesia for Pain Management After Laparoscopic Surgery: a Randomized, Double-blind, Active-controlled Pilot Tria","Inclusion Criteria:\n\n1. Aged \\>= 18 years but \\\u003C 75 years;\n2. Scheduled to undergo elective laparoscopic colorectal surgery with an expected duration of \\>=1 hour;\n3. The incisional pain can be covered by the transversus abdominis plane block or rectus sheath block; yet patients still require postoperative patient-controlled intravenous analgesia.\n\nExclusion Criteria:\n\n1. Presence of preoperative cognitive impairment (Mini-Mental State Examination \\[MMSE\\] score \\\u003C 27), or inability to communicate due to language barrier;\n2. Body mass index (BMI) \\> 30 kg\u002Fm² or \\\u003C 18 kg\u002Fm²;\n3. Presence of poorly controlled or untreated comorbidities, including but not limited to the following: hypertension characterized by a resting systolic blood pressure (SBP) \\> 180 mmHg and\u002For diastolic blood pressure (DBP) \\> 110 mmHg, coronary artery disease with unstable angina or myocardial infarction within 6 months, heart failure rated as New York Heart Association classification \\>= III, severe chronic obstructive pulmonary disease (or in a state of acute exacerbation), severe hepatic insufficiency (Child-Pugh grade C), severe renal insufficiency (estimated glomerular filtration rate \\\u003C 30 ml\u002Fmin\u002F1.73m²), or American Society of Anesthesiologists (ASA) physical status classification \\>= IV;\n4. Continuous use of opioid analgesics for more than 10 days for any reason, or alcohol abuse (average daily intake of pure alcohol \\> 36 g) within 3 months before screening;\n5. Preoperative use of opioid or non-opioid analgesics with the interval between the last administration and randomization shorter than five half-lives of the drug or the duration of drug action (whichever is longer);\n6. Known allergies or contraindications to opiates or other medications that may be used in this study, such as anesthetics, antiemetics, and nonsteroidal anti-inflammatory drugs (NSAIDs);\n7. Anticipated need for postoperative mechanical ventilation；\n8. Other conditions that are considered unsuitable for study participation.","75 Years",{"count":180,"type":22},140,[182],"PHASE4","Visceral pain following laparoscopic surgery is frequently underestimated, yet it is associated with a range of adverse outcomes. Effective visceral pain management should constitute an essential component of postoperative analgesic strategies following laparoscopic procedures. However, conventional analgesic agents, including μ-opioid receptor agonists, lack specificity for visceral pain. Anrikefon, a novel selective peripheral κ-opioid receptor agonist, demonstrates unique efficacy in alleviating visceral pain with a favorable safety profile. Preliminary studies showed that a single intravenous dose of anrikefon effectively alleviates postoperative pain after abdominal surgery with a low risk of adverse effects. The investigators hypothesize that an appropriate dosing regimen of anrikefon administered via patient-controlled intravenous analgesia (PCIA) pump, as part of a multimodal analgesic strategy, can specifically target and alleviate visceral pain after laparoscopic surgery, thereby achieving comprehensive postoperative analgesia.",[28,185,186,187],"Visceral Pain, Postoperative","Anrikefon","Patient-controlled Intravenous Analgesia",[189,190,186,191],"Laparoscopic surgery","Visceral pain, Postoperative","Patient-controlled intravenous analgesia","2026-04-22",{"date":194,"type":41},"2026-04-24",{"date":196,"type":41},"2026-04-14",{"date":198,"type":22},"2027-04",{"name":200,"class":48},"Peking University First Hospital",{"id":202,"slug":203,"hasResults":12,"nctId":204,"briefTitle":205,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":12,"sex":102,"minAge":18,"maxAge":59,"enrollmentInfo":208,"targetDuration":4,"studyType":23,"phases":210,"briefSummary":211,"conditions":212,"keywords":220,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":236},"100631180","safety-and-performance-of-a-pelvic-floor-mesh-implant-for-laparoscopic-sacrocolpopexy-progynious-100631180","NCT07497321","Safety and Performance of a Pelvic Floor Mesh Implant for Laparoscopic Sacrocolpopexy (ProGYNious)","ProGYNious","Inclusion Criteria:\n\n* Subject is a candidate for surgical repair of pelvic organ prolapse by ProGYNious implant according to the indication of the product under evaluation\n* Symptomatic pelvic organ prolapse with POP-Q \\>= 2\n* Age \\>18 years and ≤ 80years\n* Subject is willing and able to cooperate with follow-up examinations\n* Subject has been informed of the study procedures and the treatment and has signed an informed consent form\n\nExclusion Criteria:\n\n* previous or concurrent cancer which may affect the successful treament with laparoscopic mesh\n* known or suspected hypersensitivity to ProGYNious mesh or a component of ProGYNious mesh (Polypropylene)\n* known severe osteoporosis\n* pregnancy, suspected pregnancy and breastfeeding\n* bleeding of unknown cause in the genital area\n* previously irradiated patients in the pelvic area\n* drug or medication abuse, medical, psychological or social circumstances that could affect the patient's participation in the study or the evaluation of the study results\n* Any previous interventions with surgical mesh for pelvic organ prolapse and\u002For urinary incontinence\n* Unable to understand study requirements or is unable to comply with follow-up schedule\n* Contraindicated according to the instruction for use of the device\n* patients with an increased risk of infection or impaired wound healing (e.g. Diabetes mellitus with HbA1c \\>10, systemic autoimmune diseases, etc.)\n* concomitant Sling\u002FTVT procedure\n* life expectancy lower than follow-up period (e.g. ASA 4)\n* non-symptomatic pelvic organ prolapse\n* chronic pain syndrome\n* chronic respiratory disease (e.g. COPD, chronic cough)",{"count":209,"type":22},100,[25],"The purpose of this clinical investigation is to collect clinical data about the ProGYNious Mesh based on a prospective clinical investigation. The primary objective is to verify the treatment outcome and success of the ProGYNious mesh implant in pelvic organ prolapse repair. The secondary objective is to confirm the safety, risks, complications and quality of life of ProGYNious as an implant for pelvic organ prolapse repair.",[213,214,28,215,216,217,218,219],"Pelvic Organ Prolapse (POP)","Synthetic Mesh","Gynecologic Laparoscopic Surgery","Sacrocolpopexy","Pelvic Floor Prolapse","Pelvic Floor","Implant",[206,221,222,223,224,225],"A.M.I.","AMI","Agency for Medical Innovation","Y Mesh","Progyn","2026-03-24",{"date":228,"type":41},"2026-03-27",{"date":230,"type":22},"2026-04-15",{"date":232,"type":22},"2028-09-30",{"name":234,"class":235},"A.M.I. Agency for Medical Innovations GmbH","INDUSTRY",5,{"id":238,"slug":239,"hasResults":12,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":4,"eligibilityCriteria":243,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":244,"targetDuration":4,"studyType":23,"phases":246,"briefSummary":247,"conditions":248,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":49},"100628178","the-efficacy-and-safety-of-liposomal-bupivacaine-in-relieving-postoperative-pain-after-laparoscopic-surgery-100628178","NCT07458256","The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery","The Efficacy and Safety of Liposomal Bupivacaine Plus Bupivacaine Local Incisional Infiltration for Postoperative Pain in Patients Undergoing Laparoscopic Surgery:A Multi-Center Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients scheduled for elective laparoscopic cholecystectomy, hernia repair, and appendectomy under general anesthesia;\n2. Ages 18 to 64 years old；\n3. American Society of Anesthesiologists (ASA) physical status of I-III；\n4. Glasgow Coma Scale (GCS) score of 15；\n5. Patients must be able to understand the nature and potential personal consequences of the clinical trial, signing of the informed consent form.\n\nExclusion Criteria:\n\n1. History of chronic pain syndrome of any cause.\n2. Patients with heart conduction block (sinus block or atrioventricular block).\n3. Patients with unstable coronary artery disease.\n4. Patients with gastric ulcer or gastric bleeding.\n5. Patients with diabetes and are being treated with insulin.\n6. Subjects with coagulation dysfunction (prothrombin time or activated partial thromboplastin time is higher than the normal threshold) or patients who are taking oral anticoagulants for other medical reasons and have not stopped it before surgery, such as warfarin or new anticoagulants rivaroxaban or dabigatran.\n7. Patients with abnormal liver function: alanine aminotransferase (ALT) and\u002For aspartate aminotransferase (AST) \\> 2× the upper limit of normal (ULN) or total bilirubin (TBIL) ≥ 1.5×ULN.\n8. Patients with renal impairment (serum creatinine \\> 176 µmol\u002FL) or receiving dialysis treatment within 28 days before surgery.\n9. Patients with a history of diagnosed mental illness or currently taking psychotropic medication.\n10. Excessive alcohol or drug abuse, chronic opioid use (more than 2 weeks or 3 days per week for more than 1 month), use of drugs with confirmed or suspected sedative or analgesic effects, or use of any painkiller within 24 h before surgery.\n11. Pregnancy or breastfeeding.\n12. Extreme body mass index (BMI) (\\\u003C 15 or \\> 35).\n13. Participation in another interventional trial that interferes with the intervention or outcome of this trial.\n14. Patients with a history of allergy to local anaesthetics or one of the study drugs.",{"count":245,"type":22},190,[25],"Compared with traditional laparotomy, laparoscopic surgery offers advantages including minimal invasiveness, accelerated patient recovery, and reduced hospital stay. Although postoperative incision pain is generally less severe than that following laparotomy, it remains a notable clinical issue that impedes patient recovery. The majority of patients report incisional discomfort, with approximately 30% to 50% requiring oral analgesics to alleviate pain symptoms. Within the first two days after laparoscopic procedures, most patients experience varying degrees of incisional pain, with peak intensity typically occurring within hours after surgery and gradually subsiding over two to three days. Studies indicate that local infiltration anesthesia at the surgical site significantly ameliorates postoperative incision pain, enhances analgesic efficacy, and shortens recovery time in patients undergoing laparoscopic surgery.Liposomal bupivacaine(LB) is a novel, long-acting, sustained-release amide-type local anesthetic, providing localized analgesic effects for up to 72 hours. Some researchers have reported the analgesic effects of LB VS traditional local anesthetics infiltration, but the current research results are highly heterogeneous. More prospective studies are needed to evaluate whether LB infiltration is superior to the traditional local anesthetics for the management of postoperative pain. The investigators designed this study to compare the analgesic effect of using LB plus bupivacaine for local infiltration with bupivacaine along for patients after laparoscopic surgery.",[28,249,250],"Liposomal Bupivacaine","Local Infiltration","2026-03-14",{"date":253,"type":41},"2026-03-17",{"date":255,"type":41},"2026-03-10",{"date":257,"type":22},"2027-06-30",{"name":47,"class":48},{"id":260,"slug":261,"hasResults":12,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":4,"eligibilityCriteria":265,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":266,"targetDuration":4,"studyType":23,"phases":268,"briefSummary":269,"conditions":270,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":273,"startDateStruct":274,"completionDateStruct":275,"leadSponsor":276,"locationsCount":49},"100628181","the-efficacy-and-safety-of-liposomal-bupivacaine-for-transversus-abdominis-plane-block-in-relieving-postoperative-pain-after-laparoscopic-surgery-in-gynecologic-oncology-100628181","NCT07458295","The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology","The Efficacy and Safety of Liposomal Bupivacaine Plus Bupivacaine Transversus Abdominis Plane Block for Postoperative Pain in Patients Undergoing Laparoscopic Surgery in Gynecologic Oncology:A Multi-Center Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients scheduled for elective Laparoscopic Surgery in Gynecologic Oncology under general anesthesia;\n2. Ages 18 to 64 years old；\n3. American Society of Anesthesiologists (ASA) physical status of I-III；\n4. Glasgow Coma Scale (GCS) score of 15；\n5. Patients must be able to understand the nature and potential personal consequences of the clinical trial, signing of the informed consent form.\n\nExclusion Criteria:\n\n1. History of chronic pain syndrome of any cause.\n2. Patients with heart conduction block (sinus block or atrioventricular block).\n3. Patients with unstable coronary artery disease.\n4. Patients with gastric ulcer or gastric bleeding.\n5. Patients with diabetes and are being treated with insulin.\n6. Subjects with coagulation dysfunction (prothrombin time or activated partial thromboplastin time is higher than the normal threshold) or patients who are taking oral anticoagulants for other medical reasons and have not stopped it before surgery, such as warfarin or new anticoagulants rivaroxaban or dabigatran.\n7. Patients with abnormal liver function: alanine aminotransferase (ALT) and\u002For aspartate aminotransferase (AST) \\> 2× the upper limit of normal (ULN) or total bilirubin (TBIL) ≥ 1.5×ULN.\n8. Patients with renal impairment (serum creatinine \\> 176 µmol\u002FL) or receiving dialysis treatment within 28 days before surgery.\n9. Patients with a history of diagnosed mental illness or currently taking psychotropic medication.\n10. Excessive alcohol or drug abuse, chronic opioid use (more than 2 weeks or 3 days per week for more than 1 month), use of drugs with confirmed or suspected sedative or analgesic effects, or use of any painkiller within 24 h before surgery.\n11. Pregnancy or breastfeeding.\n12. Extreme body mass index (BMI) (\\\u003C 15 or \\> 35).\n13. Participation in another interventional trial that interferes with the intervention or outcome of this trial.\n14. Patients with a history of allergy to local anaesthetics or one of the study drugs.",{"count":267,"type":22},110,[25],"Laparoscopic surgery, characterized by minimal invasiveness, rapid recovery, and shorter hospital stays, has been widely adopted in Gynecologic Oncology. However, the elevation and stretching of the diaphragm following pneumoperitoneum, combined with increased intra-abdominal pressure compressing visceral organs and causing ischemia-hypoxia, can trigger systemic inflammatory responses and lead to postoperLaparoscopic surgery, characterized by minimal invasiveness, rapid recovery, and shorter hospital stays, has been widely adopted in gynecological procedures. However, the elevation and stretching of the diaphragm following pneumoperitoneum, combined with increased intra-abdominal pressure compressing visceral organs and causing ischemia-hypoxia, can trigger systemic inflammatory responses and lead to postoperative pain. Inadequate or delayed pain management may prolong hospitalization, and some patients may develop chronic pain, resulting in altered behavioral patterns. As one of the analgesic strategies after abdominal surgery, transversus abdominis plane block (TAPB) not only reduces opioid consumption and the incidence of complications but also avoids adverse effects associated with epidural analgesia. Nevertheless, the analgesic duration provided by a single-injection TAPB is limited, while continuous TAPB faces constraints in clinical application due to challenges such as catheter fixation.Inadequate or delayed pain management may prolong hospitalization, and some patients may develop chronic pain, resulting in altered behavioral patterns. As one of the analgesic strategies after abdominal surgery, TAPB not only reduces opioid consumption and the incidence of complications but also avoids adverse effects associated with epidural analgesia. Nevertheless, the analgesic duration provided by a single-injection TAPB is limited, while continuous TAPB faces constraints in clinical application due to challenges such as catheter fixation. Liposomal bupivacaine(LB) is a novel, long-acting, sustained-release amide-type local anesthetic, providing localized analgesic effects for up to 72 hours.However, its efficacy and safety in laparoscopic surgery not yet been fully validated. Based on this premise, the present study aims to evaluate and compare the clinical outcomes of Ultrasound-guided TAPB utilizing liposomal bupivacaine plus bupivacaine for postoperative pain management in patients undergoing Laparoscopic Surgery in Gynecologic Oncology.",[28,271,249,272],"Gynecologic Oncology Patient","Transversus Abdominis Plane Block",{"date":253,"type":41},{"date":255,"type":41},{"date":257,"type":22},{"name":47,"class":48},{"id":278,"slug":279,"hasResults":12,"nctId":280,"briefTitle":281,"officialTitle":282,"acronym":4,"eligibilityCriteria":243,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":283,"targetDuration":4,"studyType":23,"phases":285,"briefSummary":286,"conditions":287,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":288,"startDateStruct":289,"completionDateStruct":290,"leadSponsor":291,"locationsCount":49},"100628180","the-efficacy-and-safety-of-liposomal-bupivacaine-for-transversus-abdominis-plane-block-in-relieving-postoperative-pain-after-laparoscopic-surgery-100628180","NCT07458282","The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery","The Efficacy and Safety of Liposomal Bupivacaine Plus Bupivacaine Transversus Abdominis Plane Block for Postoperative Pain in Patients Undergoing Laparoscopic Surgery:A Multi-Center Randomized Controlled Trial",{"count":284,"type":22},318,[25],"Laparoscopic surgery has become the preferred approach for abdominal surgical interventions due to its advantages of minimal invasiveness, rapid recovery, and reduced complication rates. Despite its minimally invasive nature, postoperative pain persists and adversely affects patient recovery. In the absence of effective pain management, acute pain may progress to chronic pain. Although opioids provide reliable analgesic effects, their associated adverse reactions limit their application following minimally invasive procedures. Regional analgesia serves as the cornerstone of multimodal analgesia, and ultrasound-guided nerve block techniques have become increasingly refined. Ultrasound-guided transversus abdominis plane block(TAPB) generally fulfills intraoperative and postoperative analgesic requirements for laparoscopic surgeries by inhibiting the transmission of nociceptive stimuli in the targeted region, thereby aiding in the prevention of central sensitization. Conventional TAPB utilize local anesthetics, which demonstrate excellent efficacy in alleviating incisional pain. However, the short duration of analgesia provided by conventional local anesthetics significantly compromises their clinical utility.Liposomal bupivacaine(LB) is a novel, long-acting, sustained-release amide-type local anesthetic, providing localized analgesic effects for up to 72 hours.However, its efficacy and safety in laparoscopic surgery not yet been fully validated. Based on this premise, the present study aims to evaluate and compare the clinical outcomes of Ultrasound-guided TAPB utilizing liposomal bupivacaine plus bupivacaine for postoperative pain management in patients undergoing laparoscopic surgery.",[28,249,272],{"date":253,"type":41},{"date":255,"type":41},{"date":257,"type":22},{"name":47,"class":48},{"id":293,"slug":294,"hasResults":12,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":298,"eligibilityCriteria":299,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":300,"targetDuration":4,"studyType":23,"phases":302,"briefSummary":304,"conditions":305,"keywords":309,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":49},"100624828","phase-3-intravenous-lidocaine-plus-port-site-ropivacaine-for-recovery-after-laparoscopic-surgery-100624828","NCT07414706","Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery","Evaluation of Postoperative Recovery When Combining Intravenous Lidocaine With Ropivacaine Infiltrations in Colorectal Laparoscopic Surgery","LivQor","Inclusion Criteria:\n\n* Patient undergoing scheduled colorectal cancer surgery via laparoscopy.\n* Patient aged 18 years or older.\n* Informed consent obtained and signed.\n* Affiliation to a social security system.\n\nExclusion Criteria:\n\n* Allergy or contraindication to lidocaine or ropivacaine.\n* Allergy or contraindication to paracetamol, nefopam ketamine, propofol, dexamethasone, sufentanil, Celebrex or parecoxib, morphine derivatives, and colorectal surgery by laparotomy\n* Colorectal surgery with a non-cancerous indication.\n* Chronic preoperative pain (defined as persistent pain for more than 3 months).\n* Preoperative use of opioids or opioid derivatives.\n* Patients with psychiatric disorders.\n* Patients for whom self-assessment of pain using a self-reported scale cannot be performed (non-communicative, non-French speaking, etc.).\n* Pregnant or breastfeeding women.\n* Patients under guardianship, curatorship, or legal protection.",{"count":301,"type":22},182,[303],"PHASE3","This randomized controlled trial evaluates whether perioperative intravenous lidocaine infusion, combined with port-site ropivacaine infiltration, improves postoperative recovery after laparoscopic abdominal surgery. Participants will be assigned 1:1 to receive either intravenous lidocaine during surgery plus ropivacaine infiltration at surgical closure, or ropivacaine infiltration alone. The primary endpoint is postoperative quality of recovery measured by the QoR-15 questionnaire. Secondary endpoints include postoperative pain and opioid consumption, as well as plasma lidocaine and ropivacaine concentrations to assess systemic exposure and safety.",[306,28,307,308],"Intravenous Lidocaine","Post Operative Recovery","Local Anaesthetic Systemic Toxicity",[310,159,311,312],"Intravenous lidocaine","post operative recovery","local anaesthetic systemic toxicity","2026-02-12",{"date":315,"type":41},"2026-02-17",{"date":317,"type":22},"2026-03",{"date":319,"type":22},"2028-09",{"name":321,"class":48},"Centre Hospitalier Universitaire, Amiens",{"id":323,"slug":324,"hasResults":12,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":12,"sex":102,"minAge":18,"maxAge":4,"enrollmentInfo":329,"targetDuration":4,"studyType":331,"phases":4,"briefSummary":332,"conditions":333,"keywords":336,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":346,"locationsCount":348},"100620123","predicting-hypothermia-in-gynecological-laparoscopic-surgery-using-machine-learning-100620123","NCT07353528","Predicting Hypothermia in Gynecological Laparoscopic Surgery Using Machine Learning","Development and Validation of a Machine Learning Model to Predict Hypothermia in Gynecological Laparoscopic Surgery Based on Preoperative Clinical Indicators: A Multicenter Prospective Cohort Study","Inclusion Criteria:\n\n* Female patients aged 18 years or older.\n* Patients scheduled for laparoscopic surgery.\n\nExclusion Criteria:\n\n* Preoperative body temperature exceeding 37.5°C or below 36.0°C.\n* History of hypothyroidism or hyperthyroidism.\n* Patients with thermoregulatory dysfunction, such as severe infection or central nervous system disorders.\n* Patients who refuse to sign the informed consent form.",{"count":330,"type":22},1000,"OBSERVATIONAL","Brief Title: Predicting Hypothermia in Gynecological Laparoscopic Surgery Using Machine Learning\n\nBrief Summary: This study aims to develop and validate a machine learning model for predicting intraoperative hypothermia (IOH) in patients undergoing gynecological laparoscopic surgery based on preoperative clinical indicators. This prospective, multicenter case-control study will enroll female patients aged 18 years and older who are scheduled for laparoscopic surgery across multiple hospitals from 2026 to 2027. The primary objective is to identify high-risk patients who may experience IOH, defined as a core temperature below 36.0°C during surgery.\n\nParticipants will be classified into two groups: the IOH group, consisting of patients who experience hypothermia, and the normal temperature group, comprising patients who maintain a core temperature of 36.0°C or higher. Data collection will include demographics, comorbidities, surgical details, anesthesia information, and preoperative laboratory results.\n\nThe primary outcome measure will be the area under the curve (AUC) of the model, assessing its predictive performance at various thresholds. Secondary outcomes will include sensitivity, positive predictive value, negative predictive value, and F1 score. The study hypothesizes that the developed machine learning model will significantly improve the accuracy and timeliness of predicting IOH, thereby enhancing patient safety during surgery and postoperative recovery. This research is expected to inform clinical practices related to preventative warming strategies, ultimately improving patient outcomes in gynecological laparoscopic surgery.",[28,334,335],"Intraoperative Hypothermia","Gynecological Surgery",[189,337,338,339],"Intraoperative hypothermia","Machine learning","Gynecology","2026-01-18",{"date":342,"type":41},"2026-01-20",{"date":344,"type":22},"2026-03-01",{"date":71,"type":22},{"name":347,"class":48},"Chengdu Jinjiang Maternity and Child Health Hospital",4,{"id":350,"slug":351,"hasResults":12,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":57,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":356,"targetDuration":4,"studyType":23,"phases":358,"briefSummary":359,"conditions":360,"keywords":365,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":368,"lastUpdatePostDateStruct":369,"startDateStruct":371,"completionDateStruct":373,"leadSponsor":375,"locationsCount":49},"100584827","comparison-the-analgesic-efficacy-of-ultrasonographic-bilateral-tap-and-anesthetic-infiltration-into-the-surgery-field-for-laparoscopic-unilateral-tep-herniorrhaphy-100584827","NCT06894420","Comparison the Analgesic Efficacy of Ultrasonographic Bilateral TAP and Anesthetic Infiltration Into the Surgery Field for Laparoscopic Unilateral TEP Herniorrhaphy","Comparison of Postoperative Analgesic Efficacy of Ultrasonographic Bilateral TAP (Transversus Abdominis Plane) Block and Anesthetic Infiltration Into Preperitoneal and the Surgical Field in Laparoscopic Unilateral TEP (Total Extraperitoneal) Herniorraphy","Inclusion Criteria:\n\n* Consenting patients,\n* She will undergo laparoscopic hernia repair surgery,\n* ASA-I-II,\n* Between the ages of 18 and 65,\n* No history of anticoagulant or antiaggregant drug use,\n* Regional anesthesia is not contraindicated and the anesthesiologist deems -appropriate for regional anesthesia,\n* Under general anesthesia and will undergo laparoscopic surgery,\n* Fully oriented and cooperative,\n* Unilateral inguinal hernia,\n* No previous surgery for inguinal hernia,\n* No incision in the lower abdomen,\n* Not using alcohol and drugs,\n* No preoperative pain and\n* Patients without symptoms of strangulated hernia will be included in the study.\n\nExclusion Criteria:\n\n* Patients without consent\n* Regional anesthesia is contraindicated,\n* Those who will undergo open abdominal surgery,\n* Not in the appropriate age range,\n* Chronic diseases such as uncontrolled DM and HT,\n* Drug allergy,\n* Taking anticoagulant or antiaggregant drugs,\n* History of chronic analgesic use,\n* Presence of active infection in the area to be blocked,\n* Will not be able to comply with postoperative pain \u002FVAS follow-up,\n* Patients with ASA-III-IV,\n* Patients with bilateral inguinal and scrotal hernias,\n* Patients who have been previously operated for inguinal hernia and have an incision in the lower abdomen,\n* Those with a history of alcohol and drug abuse\n* Preoperative pain and\n* Those with symptoms of strangulated hernia will not be included in this study.",{"count":357,"type":22},60,[25],"Laparoscopic inguinal hernia repair is a common surgical procedure, but postoperative pain management remains a challenge. This prospective, randomized study aims to compare the analgesic efficacy of preperitoneal and surgical site anesthetic infiltration with ultrasound-guided bilateral transversus abdominis plane (TAP) block in patients undergoing laparoscopic unilateral total extraperitoneal (TEP) herniorrhaphy. Sixty patients will be randomly allocated into two groups: Group-I will receive preperitoneal and surgical site infiltration with bupivacaine, while Group-II will receive ultrasound-guided bilateral TAP block with bupivacaine. The primary outcomes will be postoperative pain scores assessed using the visual analog scale (VAS) and additional analgesic requirements. Secondary outcomes will include postoperative hospital stay duration and cost-effectiveness. Demographic data, ASA scores, comorbidities, and operation times will be recorded. Postoperative pain will be managed with a multimodal approach, including paracetamol and NSAIDs. Rescue analgesia will be provided with intravenous paracetamol. Statistical analysis will be performed using t-tests, ANOVA, Wilcoxon-Mann-Whitney tests, and chi-square tests, as appropriate. This study aims to determine the optimal and most beneficial method for postoperative pain management and patient comfort following laparoscopic inguinal hernia repair.",[28,361,362,363,364],"Herniorrhaphy","Inguinal Hernia Unilateral","Transversus Abdominis Plane (TAP) Block","Postoperative Analgesia",[189,366,367,363],"Inguinal hernia","postoperative analgesia","2025-09-19",{"date":370,"type":41},"2025-09-24",{"date":372,"type":41},"2025-09-04",{"date":374,"type":22},"2026-06-30",{"name":376,"class":377},"Başakşehir Çam & Sakura City Hospital","OTHER_GOV",{"id":379,"slug":380,"hasResults":12,"nctId":381,"briefTitle":382,"officialTitle":383,"acronym":4,"eligibilityCriteria":384,"healthyVolunteers":12,"sex":102,"minAge":18,"maxAge":4,"enrollmentInfo":385,"targetDuration":4,"studyType":23,"phases":387,"briefSummary":388,"conditions":389,"keywords":392,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":236},"100598074","safety-and-performance-of-a-pelvic-floor-mesh-implant-latgynious-100598074","NCT07066761","Safety and Performance of a Pelvic Floor Mesh Implant (LatGYNious)","Safety and Performance of a Pelvic Floor Mesh Implant for Laparoscopic Lateral Suspension (LatGYNious)","Inclusion Criteria:\n\n* Symptomatic prolapse in one of the 3 compartments from grade 2 with or without uterus\n* Subject is candidate for a surgical treatment of pelvic organ prolapse\n* Subject is willing and able to cooperate with follow-up examinations\n* Subject has been informed of the study procedures and the treatment and has signed an informed consent form and provided authorization to use and disclose information for research purposes.\n\nExclusion Criteria:\n\n* Previous surgical treatment with a mesh implant for pelvic organ prolapse (mesh implant in anterior or posterior compartment)\n* Active immunotherapy which may negatively affect the treatment with a surgical mesh\n* Active cancer of the vagina \u002F cervix \u002F rectum\n* . known or suspected hypersensitivity to Polypropylene\n* Pregnancy\n* participation in another study at the same time\n* Unable to understand study requirements or is unable to comply with follow-up schedule\n* Contraindicated according to the instruction for use of the device",{"count":386,"type":22},85,[25],"The purpose of the clinical investigation is to verify that the investigational device (LatGYNious) is appropriate to significantly improve the pelvic organ prolapse in patients.",[213,390,391,28],"Genital Prolapse","Uterus Prolapse",[393],"Laparoscopic lateral suspension (LLS)","2025-07-15",{"date":396,"type":41},"2025-07-18",{"date":398,"type":41},"2025-07-01",{"date":400,"type":22},"2027-07",{"name":234,"class":235},{"id":403,"slug":404,"hasResults":12,"nctId":405,"briefTitle":406,"officialTitle":406,"acronym":407,"eligibilityCriteria":408,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":409,"targetDuration":411,"studyType":331,"phases":4,"briefSummary":412,"conditions":413,"keywords":415,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":421,"completionDateStruct":422,"leadSponsor":424,"locationsCount":4},"100593367","study-of-the-relationship-between-curarization-and-pneumoperitoneum-in-laparoscopic-surgery-100593367","NCT07005518","Study of the Relationship Between Curarization and Pneumoperitoneum in Laparoscopic Surgery","PneumandTOF","Major patient, operated on by robot-assisted laparoscopic surgery, by two surgeons targeted for their similar working surgical technique.",{"count":410,"type":22},200,"3 Months","The number of surgical procedures is increasing worldwide (1). Laparoscopic surgery is one of the surgical techniques that has become indispensable. Laparoscopic surgery is less invasive than laparotomy. Laparoscopic surgery is performed in several stages, one of which involves the creation of a peritoneal detachment. This detachment is achieved by the addition of a gas (CO2), which requires total relaxation of the abdominal muscle fibers. To achieve this, it is advisable to administer a muscle relaxant called curare (2). Curare-induced neuromuscular block, its depth and its release must be monitored during surgery. Curares act as acetylcholine antagonists, inducing neuromuscular block by competing with this neurotransmitter. In France, only one type of device, called an accelerometer, is used to monitor curarization. This device couples electrical stimulation of a nerve with an accelerometer. Curarization can be said to be deep, moderate, residual or absent. Despite curarization appearing deep to the accelerometer, operating conditions do not always seem ideal for abdominal contraction. Indeed, the muscles tested with this device do not concern the muscles involved in laparoscopic surgery.\n\nA currently unexploited surgical parameter, variation in insufflation pressure, could change our approach to intraoperative curarization.",[28,414,108],"Neuromuscular Blocking Agents",[416,417],"pneumoperitoneum pressure","curarization","2025-06-17",{"date":420,"type":41},"2025-06-18",{"date":398,"type":22},{"date":423,"type":22},"2027-11-01",{"name":425,"class":48},"Poitiers University Hospital",{"id":427,"slug":428,"hasResults":12,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":4,"eligibilityCriteria":432,"healthyVolunteers":57,"sex":17,"minAge":433,"maxAge":58,"enrollmentInfo":434,"targetDuration":4,"studyType":23,"phases":436,"briefSummary":437,"conditions":438,"keywords":440,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":448,"startDateStruct":450,"completionDateStruct":452,"leadSponsor":454,"locationsCount":49},"100587491","role-of-individualized-peep-vs-fixed-peep-in-mechanical-ventilation-during-laparoscopic-surgeries-100587491","NCT06929078","Role of Individualized PEEP Vs Fixed PEEP in Mechanical Ventilation During Laparoscopic Surgeries","Role of Individualized Positive End-expiratory Pressure Versus Fixed Positive End-expiratory Pressure in Mechanical Ventilation During Laparoscopic Surgeries","Inclusion Criteria:\n\n* 1\\. Age Limit : 25 years to 65 years\n\n  2\\. Patients undergoing laparoscopic suregeries\n\n  3\\. ASA 1-3\n\nExclusion Criteria:\n\n* 1\\. Hemodynamic instability 2. Bronchospam 3. Patients having COPD 4. History of pulmonary bulla 5. Patients having history of pneumothora","25 Years",{"count":435,"type":22},75,[25],"To compare the effects of Individualized positive end-expiratory pressure with recruitment maneuver on respiratory parameters and oxygenation in mechanical ventilation during laparoscopic surgeries with the fixed positive end-expiratory pressure and conventional mechanical ventilation without positive end-expiratory pressure.",[28,108,439],"Positive End Expiratory Pressure (PEEP)",[441,442,443,444,445,446],"mechanical ventilation","lung compliance","positive end-expiratory pressure","respiratory mechanics","oxygenation index","driving pressure","2025-04-08",{"date":449,"type":41},"2025-04-16",{"date":451,"type":22},"2025-05",{"date":453,"type":22},"2025-11",{"name":455,"class":48},"Noor-Ul-Ain",{"id":457,"slug":458,"hasResults":12,"nctId":459,"briefTitle":460,"officialTitle":461,"acronym":4,"eligibilityCriteria":462,"healthyVolunteers":12,"sex":102,"minAge":18,"maxAge":4,"enrollmentInfo":463,"targetDuration":4,"studyType":23,"phases":465,"briefSummary":466,"conditions":467,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":477,"locationsCount":49},"100584165","uterine-round-ligament-preservation-vs-resection-in-laparoscopic-inguinal-hernia-repair-in-womena-multicenterstratified-randomized-controlled-trial-100584165","NCT06885788","Uterine Round Ligament Preservation Vs Resection in Laparoscopic Inguinal Hernia Repair in Women：A Multicenter,Stratified Randomized Controlled Trial","Comparative Study on the Effect of Uterine Round Ligament Preservation Vs Resection in Laparoscopic Inguinal Hernia Repair in Women： a Multicenter,Stratified Randomized Controlled Trial","Inclusion Criteria:\n\n* ►Age : Female patients over 18 years of age without a childbearing requirement\n\n  * Diagnosis and basis : Female patients diagnosed with Unilateral inguinal hernia.\n  * agreed to participate in this study and signed the informed consent form.\n\nExclusion Criteria:\n\n* ►Combined with severe heart, liver, kidney and other diseases.\n\n  * pregnant or lactating women.\n  * those with surgical contraindications.",{"count":464,"type":22},466,[25],"This study aims to compare the clinical effects of uterine round ligament preservation versus resection in laparoscopic inguinal hernia repair in women.The primary outcomes included Time required for patient surgery.The secondary outcomes included Inguinal hernia recurrence,quality of life assessment,Indicators of postoperative recovery,, et al.",[468,28,469],"Inguinal Hernia","Randomized Controlled Trial","2025-03-20",{"date":472,"type":41},"2025-03-25",{"date":474,"type":41},"2024-09-20",{"date":476,"type":22},"2027-03-01",{"name":478,"class":377},"Nanchong Central Hospital",{"id":480,"slug":481,"hasResults":12,"nctId":482,"briefTitle":483,"officialTitle":484,"acronym":485,"eligibilityCriteria":486,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":487,"targetDuration":4,"studyType":23,"phases":489,"briefSummary":490,"conditions":491,"keywords":494,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":507,"locationsCount":49},"100581479","recruitment-maneuvers-and-peep-guided-electrical-impedance-tomography-for-abdominal-laparoscopic-surgery-patients-100581479","NCT06850844","Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography for Abdominal Laparoscopic Surgery Patients","Impact of Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography on Regional Ventilation, Gas Exchange, and Pulmonary Mechanics in in Abdominal Laparoscopic Surgery Patients","PEEP-EIT","Inclusion Criteria:\n\n* Age \\> 18 years\n* Scheduled for abdominal laparoscopy surgery\n* At increased (i.e., intermediate or high) risk of postoperative pulmonary complications according to the \"Assess Respiratory Risk in Surgical Patients in Catalonia\" (ARISCAT) score (≥ 26 points)\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Major previous lung surgery (e.g., lung resection)\n* Severe chronic obstructive pulmonary disease and\u002For severe emphysema\n* Increased intracranial pressure\n* Contraindications for EIT (pacemakers, automatic external defibrillators, cases of chest trauma or recent chest surgery limiting EIT belt application)\n* Presence of pneumothorax that is either undrained or newly occurred.\n* Unstable hemodynamics with a mean arterial pressure \\\u003C 60 mmHg and unresponsive to resuscitation measures, and\u002For heart rate \\\u003C 60 bpm.\n* Pregnancy.\n* Severe neuromuscular disease.",{"count":488,"type":22},70,[25],"Abdominal laparoscopy is widely utilized due to its benefits, including minimal invasiveness, improved cosmetic outcomes, and shorter hospital stays. However, the use of intraoperative pneumoperitoneum and general anesthesia with mechanical ventilation may lead to postoperative pulmonary complications, such as atelectasis. This condition can result in diminished respiratory mechanics and impaired gas exchange.\n\nIn recent years, intraoperative lung-protective mechanical ventilation techniques, including recruitment maneuvers (RMs) and positive end-expiratory pressure (PEEP) strategies, have gained popularity. These approaches aim to prevent the repeated collapse and reopening of alveoli, thereby reducing the risk of atelectasis. Nonetheless, determining the optimal PEEP level for individual patients remains a complicated and unresolved issue.\n\nElectrical impedance tomography (EIT) is a bedside imaging technique that assesses regional ventilation distribution, providing a method for personalizing PEEP settings in mechanically ventilated patients. By addressing the competing risks of alveolar overdistension and collapse, EIT enhances the precision of PEEP titration.\n\nThis study aims to compare the effects of recruitment maneuvers and EIT-guided PEEP selection against conventional ventilation on regional ventilation, gas exchange, and pulmonary mechanics in patients undergoing abdominal laparoscopic surgery.",[28,492,493],"Positive End-Expiratory Pressure","Electrical Impedance Tomography",[28,492,495,496,497,498,499],"Recruitment Maneuver","electrical impedance tomography","blood oxygenation","regional ventilation","pulmonary mechanics","2025-02-23",{"date":502,"type":41},"2025-02-27",{"date":504,"type":41},"2024-08-01",{"date":506,"type":22},"2025-12-30",{"name":508,"class":48},"Nguyen Dang Thu",{"id":510,"slug":511,"hasResults":12,"nctId":512,"briefTitle":513,"officialTitle":514,"acronym":4,"eligibilityCriteria":515,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":516,"targetDuration":4,"studyType":331,"phases":4,"briefSummary":518,"conditions":519,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":521,"lastUpdatePostDateStruct":522,"startDateStruct":524,"completionDateStruct":526,"leadSponsor":528,"locationsCount":4},"100580498","trend-correlation-between-end-tidal-and-arterial-carbon-dioxide-during-laparoscopic-surgery-in-trendelenburg-position-100580498","NCT06838078","Trend Correlation Between End-Tidal and Arterial Carbon Dioxide During Laparoscopic Surgery in Trendelenburg Position","Evaluation of the Trend Correlation Between End-Tidal and Arterial Carbon Dioxide Partial Pressures During Laparoscopic Surgery in the Trendelenburg Position: A Prospective Observational Study","Inclusion Criteria:\n\n* Scheduled to undergo laparoscopic surgery in the Trendelenburg position\n* Planned to receive invasive arterial blood pressure monitoring as part of routine clinical care (independent of the study)\n\nExclusion Criteria:\n\n* Chronic obstructive pulmonary disease\n* Pulmonary hypertension\n* Active systemic infection",{"count":517,"type":22},79,"In this study, we want to find out whether a person's \"end-tidal carbon dioxide\" (ETCO₂)-a value measured from the air they breathe out-accurately reflects the amount of carbon dioxide in their blood, called \"arterial carbon dioxide\" (PaCO₂).\n\nWe are focusing on people having laparoscopic (keyhole) surgery in the Trendelenburg position, which involves tilting the patient's head down to help the surgeon see the surgical area better. This position can sometimes affect carbon dioxide levels in the blood. Right now, doctors must draw blood samples to measure the PaCO₂ level. If we can show that ETCO₂ readings are reliable, doctors may not need to draw blood samples as often.\n\nDuring surgery, patients already need a small tube (catheter) in an artery so doctors can closely monitor their blood pressure. Whenever the anesthesiologist decides a blood sample is needed, we will note the blood's PaCO₂ level and compare it with the ETCO₂ reading taken at the same time. We will also record other measurements like heart rate, blood pressure, and temperature.\n\nBy comparing these measurements, we hope to learn if the ETCO₂ readings can reliably match the changes in PaCO₂ over time, making it a useful tool to monitor carbon dioxide levels in this type of surgery without needing as many blood tests. We plan to include 79 patients in this study, which should give us enough measurements to see how closely these two methods match.",[28,520],"Trendelenburg Position","2025-02-15",{"date":523,"type":41},"2025-02-20",{"date":525,"type":22},"2025-04-01",{"date":527,"type":22},"2025-06-15",{"name":529,"class":48},"Koç University",{"id":531,"slug":532,"hasResults":12,"nctId":533,"briefTitle":534,"officialTitle":534,"acronym":4,"eligibilityCriteria":535,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":536,"targetDuration":4,"studyType":23,"phases":538,"briefSummary":539,"conditions":540,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":541,"lastUpdatePostDateStruct":542,"startDateStruct":544,"completionDateStruct":546,"leadSponsor":548,"locationsCount":49},"100578011","a-comparative-study-of-ventilation-strategies-in-different-surgical-positions-on-intracranial-pressure-and-cerebral-blood-flow-during-laparoscopic-surgery-100578011","NCT06805747","A Comparative Study of Ventilation Strategies in Different Surgical Positions on Intracranial Pressure and Cerebral Blood Flow During Laparoscopic Surgery","Inclusion Criteria:\n\n* Age: Unrestricted\n* American Society of Anesthesiologists (ASA) Physical Status: Class I-III\n* Surgical Position: Requires the use of either the Trendelenburg position or the Reverse Trendelenburg position during the procedure.\n* Ventilation: Planned mechanical ventilation is required during the procedure, with suitability for one of the following modes: pressure-regulated volume-controlled ventilation (PRVC), conventional volume-controlled ventilation (C-VCV), or pressure-controlled ventilation (PCV).\n\nExclusion Criteria:\n\n* Significant Cardiopulmonary Disease:\n* Intracranial Disease\n* Severe Coagulopathy or Current Anticoagulant Therapy\n* Presence of Psychiatric Illness, Cognitive Impairment, or other condition that precludes the ability to understand or comply with the study.",{"count":537,"type":22},240,[25],"The purpose of this clinical trial is to investigate the effects of laparoscopic surgery in the Trendelenburg and Reverse Trendelenburg positions, and variable tidal volume ventilation (V-VCV), pressure-regulated volume-controlled ventilation (PRVC), conventional volume-controlled ventilation (C-VCV), and pressure-controlled ventilation (PCV) on esophageal pressure, airway pressure, tidal volume, intracranial pressure, and cerebral blood flow.\n\nThe study aims to address the following primary questions:Does laparoscopic surgery in the Trendelenburg or Reverse Trendelenburg position increase esophageal pressure, airway pressure, and intracranial pressure, and decrease tidal volume and cerebral blood flow? Do variable tidal volume ventilation (V-VCV), pressure-regulated volume-controlled ventilation (PRVC), conventional volume-controlled ventilation (C-VCV), or pressure-controlled ventilation (PCV) increase esophageal pressure, airway pressure, and intracranial pressure, and decrease tidal volume and cerebral blood flow? The investigators will compare variable tidal volume ventilation (V-VCV), pressure-regulated volume-controlled ventilation (PRVC), conventional volume-controlled ventilation (C-VCV), and pressure-controlled ventilation (PCV) to determine which ventilation mode results in the least physiological disturbance for patients.\n\nParticipant Procedures:\n\nParticipants will: Be positioned according to the surgical requirements.Be randomly assigned to mechanical ventilation with either variable tidal volume ventilation (V-VCV), pressure-regulated volume-controlled ventilation (PRVC), conventional volume-controlled ventilation (C-VCV), or pressure-controlled ventilation (PCV).\n\nUndergo assessments at the following time points: immediately after endotracheal intubation, immediately after pneumoperitoneum, immediately after position change (Trendelenburg or Reverse Trendelenburg), 30 minutes after position change, and 1 hour after position change.\n\nHave their esophageal pressure, airway pressure, intracranial pressure, tidal volume, and internal jugular vein blood flow recorded at each assessment time point.",[28],"2025-01-28",{"date":543,"type":41},"2025-02-03",{"date":545,"type":22},"2025-02-01",{"date":547,"type":22},"2025-05-10",{"name":549,"class":48},"Inner Mongolia Baogang Hospital",{"id":551,"slug":552,"hasResults":12,"nctId":553,"briefTitle":554,"officialTitle":555,"acronym":4,"eligibilityCriteria":556,"healthyVolunteers":12,"sex":17,"minAge":557,"maxAge":558,"enrollmentInfo":559,"targetDuration":4,"studyType":331,"phases":4,"briefSummary":554,"conditions":560,"keywords":562,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":566,"lastUpdatePostDateStruct":567,"startDateStruct":569,"completionDateStruct":571,"leadSponsor":573,"locationsCount":4},"100560018","comparison-of-target-controlled-infusion-anesthesia-and-inhalation-anesthesia-in-pediatric-laparoscopic-surgeries-100560018","NCT06571682","Comparison of Target Controlled Infusion Anesthesia and Inhalation Anesthesia in Pediatric Laparoscopic Surgeries","Comparison of the Effect of Anesthesia Applied by Target Controlled Infusion Method and Inhalation Anesthesia Method on Patient Outcomes in Pediatric Patients Undergoing Laparoscopic Surgery","Inclusion Criteria:\n\n* Children aged 3-12 years\n* Patients weighing over 10 kilograms\n* Patients who will undergo inguinal hernia surgery\n* ASA (American Society of Anesthesiologists) classification I and II pediatric patients.\n\nExclusion Criteria:\n\n* Absence of systemic illness.\n* ASA (American Society of Anesthesiologists) classification III and above pediatric patients.","3 Years","12 Years",{"count":357,"type":22},[28,561],"Target Controlled Infusion",[563,561,564,565],"Pediatric Laparoscopic Surgery","Propofol","Sevoflurane","2024-08-23",{"date":568,"type":41},"2024-08-26",{"date":570,"type":22},"2024-09-15",{"date":572,"type":22},"2025-03-30",{"name":574,"class":48},"TC Erciyes University",{"id":576,"slug":577,"hasResults":12,"nctId":578,"briefTitle":579,"officialTitle":580,"acronym":581,"eligibilityCriteria":582,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":583,"targetDuration":4,"studyType":331,"phases":4,"briefSummary":585,"conditions":586,"keywords":596,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":599,"lastUpdatePostDateStruct":600,"startDateStruct":602,"completionDateStruct":604,"leadSponsor":606,"locationsCount":608},"100551962","evaluation-of-intra-operative-photographs-for-the-assessment-of-a-proper-lymphadenectomy-in-minimally-invasive-gastrectomies-for-gastric-cancer-photonodes-100551962","NCT06466902","Evaluation of Intra-operative Photographs for the Assessment of a Proper Lymphadenectomy in Minimally-invasive Gastrectomies for Gastric Cancer (PhotoNodes)","Evaluation of Intra-operative Photographs for the Assessment of a Proper Lymphadenectomy in Minimally-invasive Gastric Cancer Surgery (PhotoNodes)","PhotoNodes","Inclusion Criteria:\n\n* All patients undergoing minimally invasive curative-intent surgery for gastric adenocarcinoma with D2 lymphadenectomy\n* Patients undergoing upfront surgery or treated with a neoadjuvant\u002Fperioperative chemotherapy\n* Total or Subtotal Gastrectomy\n* Laparoscopic or Robotic approach\n\nExclusion Criteria:\n\n* Age less than 18 year old\n* Esophago-gastric junction cancer Siewert type I, II or III\n* Metastatic disease\n* Lymphadenectomy less than D2\n* Open surgery\n* Conversion to open surgery\n* Palliative gastrectomy\n* R1 or R2 resection\n* Multivisceral resection except for cholecystectomy\n* Surgical procedures other than subtotal or total gastrectomy\n* A single node station rated as unevaluable by more than one reviewer",{"count":584,"type":22},326,"Even after the wide introduction of chemo\u002Fradiotherapy in the treatment algorithm, adequate surgery remains the cornerstone of gastric cancer treatment with curative intent. A proper D2 lymphadenectomy is associated with improved cancer specific survival as confirmed in Western countries by fifteen-year follow-up results of Dutch and Italian randomized trials.\n\nIn clinical practice, the total number of harvested lymph nodes is often considered as a surrogate marker for adequate D2 lymphadenectomy; nonetheless, the number of retrieved nodes does not necessarily correlate with residual nodes, which intuitively could represent a more reliable marker of surgical adequacy. The availability of an efficient tool for evaluating the absence of residual nodes in the operative field at the end of node dissection could better correlate with survival outcomes.\n\nThe goal of this multicentric observational prospective study is to test the reliability of a new score (PhotoNodes Score) created to rate the quality of the lymphadenectomy performed during minimally invasive gastrectomy for gastric cancer. The score is assigned by assessing the absence of residual nodes at the end of node dissection on a set of laparoscopic\u002Frobotic high quality intraoperative images collected from each patient undergoing a minimally invasive gastrectomy with D2 node dissection.\n\nIdeally, this tool could be a new indicator of the quality of D2 dissection and could assume a prognostic role in the treatment of gastric cancer.",[587,588,589,590,591,28,592,593,594,595],"Gastric Cancer","Gastric Adenocarcinoma","Lymphadenectomy","Minimally Invasive Surgery","Gastrectomy for Gastric Cancer","Robotic Surgery","Survival Outcomes","Survival Analysis","Quality Of Care",[597,598],"D2 Lymphadenectomy quality assessment","Minimally invasive gastric cancer oncologic surgery","2024-07-03",{"date":601,"type":41},"2024-07-05",{"date":603,"type":41},"2022-12-22",{"date":605,"type":22},"2027-12",{"name":607,"class":48},"Azienda Ospedaliero-Universitaria di Parma",8,{"id":610,"slug":611,"hasResults":12,"nctId":612,"briefTitle":613,"officialTitle":614,"acronym":4,"eligibilityCriteria":615,"healthyVolunteers":12,"sex":102,"minAge":18,"maxAge":4,"enrollmentInfo":616,"targetDuration":4,"studyType":23,"phases":618,"briefSummary":619,"conditions":620,"keywords":621,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":626,"lastUpdatePostDateStruct":627,"startDateStruct":629,"completionDateStruct":631,"leadSponsor":632,"locationsCount":49},"100542130","short-title-standard-vs-lower-pressure-pneumoperitoneum-100542130","NCT06338865","Short Title: Standard vs. Lower Pressure Pneumoperitoneum","Standard vs. Lower Pressure Pneumoperitoneum in Laparoscopic Gynecologic Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* 18 years of age or older\n* Undergoing laparoscopic surgery at Cedars-Sinai Medical Center with a surgeon in the Minimally Invasive Gynecologic Surgery division.\n\nExclusion Criteria:\n\n* Pregnancy\n* Urgent\u002Fnon-scheduled surgery\n* Scheduled for planned or possible concomitant non-gynecologic surgery (e.g., urologic or colorectal procedure)\n* Baseline opioid use\n* Allergy or intolerance to bupivacaine (or amide class of anesthetics), oxycodone, acetaminophen, or ibuprofen\n* Planned post-operative admission",{"count":617,"type":22},294,[25],"This study aims to investigate the effect of varying insufflation pressures on post-operative pain and adequacy of surgical field visualization among patients undergoing laparoscopic surgery with a minimally invasive gynecologic surgeon.",[28],[159,622,623,624,36,625],"insufflation","pneumoperitoneum","gynecologic surgery","robotic surgery","2024-05-08",{"date":628,"type":41},"2024-05-10",{"date":630,"type":41},"2024-05-03",{"date":198,"type":22},{"name":633,"class":48},"Cedars-Sinai Medical Center",{"id":635,"slug":636,"hasResults":12,"nctId":637,"briefTitle":638,"officialTitle":639,"acronym":640,"eligibilityCriteria":641,"healthyVolunteers":57,"sex":102,"minAge":642,"maxAge":4,"enrollmentInfo":643,"targetDuration":4,"studyType":23,"phases":645,"briefSummary":646,"conditions":647,"keywords":653,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":659,"lastUpdatePostDateStruct":660,"startDateStruct":662,"completionDateStruct":664,"leadSponsor":666,"locationsCount":4},"100519946","evaluating-artisential-laparoscopic-instruments-in-gynecologic-surgery-100519946","NCT06050161","Evaluating Artisential Laparoscopic Instruments in Gynecologic Surgery","Minimally Invasive Gynecologic Surgery Utilizing the Artisential Articulating Laparoscopic Instruments","MIGS-ART","Inclusion Criteria:\n\n* Patient scheduled for robotic or laparoscopic total hysterectomy\n* Patient scheduled for robotic or laparoscopic sacrocolpopexy\n\nExclusion Criteria:\n\n* Not a candidate for the above surgical procedures","22 Years",{"count":644,"type":22},50,[25],"This study evaluates the efficacy and safety of Artisential laparoscopic instruments in minimally invasive gynecologic surgery.",[648,649,650,28,651,652,590],"Pelvic Organ Prolapse","Abnormal Uterine Bleeding","Mesh Augmentation","Robotic Surgical Suturing","Laparoscopic Hysterectomy",[189,654,655,656,216,657,658],"Laparoscopic suturing","Laparoscopic instruments","Pelvic organ prolapse","Minimally invasive surgery","Vaginal cuff closure","2023-09-17",{"date":661,"type":41},"2023-09-22",{"date":663,"type":22},"2023-09-20",{"date":665,"type":22},"2027-09-20",{"name":667,"class":48},"Kern Medical Center"]