[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"laparoscopic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:laparoscopic":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,38,66,91,120,143,170,193,214],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":4},"100642182","clinical-outcomes-of-intubation-techniques-in-anesthesia-100642182",false,"NCT07661186","Clinical Outcomes of Intubation Techniques in Anesthesia","Clinical Outcomes of Intubation Techniques in Anesthesia; an Observational Study.","Inclusion Criteria:\n\n* Patients over 18 years of age ASA 1-2-3 patients undergoing elective laparoscopic cholecystectomy surgery Patients who agreed to participate in the study\n\nExclusion Criteria:\n\n* Patients for whom difficult intubation is considered Patients with neurological disorders Patients with mental retardation Patients who refused to participate in the study.","ALL","18 Years",{"count":19,"type":20},165,"ESTIMATED","1 Day","OBSERVATIONAL","Before surgery, patients will be evaluated by an anesthesiologist at the anesthesia clinic and informed in detail about the study. Patients who do not wish to participate in the study will absolutely not be included, and this will not affect the patients' treatment process in any way. The anesthesia method to be applied to patients who agree to participate in the study will not differ from routine anesthesia application. In other words, no additional medication, procedure, or different anesthesia method will be applied to patients within the scope of the study. After the surgery is completed, patients will be monitored in the recovery room and during their hospital stay. During this monitoring, it will be observed and recorded whether patients have complaints such as sore throat, cough, or hoarseness.",[25],"Laparoscopic","NOT_YET_RECRUITING","2026-06-18",{"date":29,"type":30},"2026-06-22","ACTUAL",{"date":32,"type":20},"2026-06-14",{"date":34,"type":20},"2026-12-15",{"name":36,"class":37},"Amasya University","OTHER",{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":45,"minAge":4,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":65},"100634987","laparotomy-vs-laparoscopy-in-endometrial-cancer-staging-100634987","NCT07546825","Laparotomy vs Laparoscopy in Endometrial Cancer Staging","Perioperative Outcomes of Surgical Staging in Patients With Early-stage Endometrial Carcinoma: Comparison Between Laparoscopy and Laparotomy in a Low-resource Setting","1. Inclusion criteria:\n\n   * Histologically confirmed endometrial carcinoma, diagnosed by endometrial biopsy or dilatation and curettage.\n   * patient candidate for pelvic lymphadenectomy according to risk stratification in endometrial cancer according to ESGO\u002FESTRO\u002FESP, 2021 (6).\n   * Planned surgical staging including: total hysterectomy, bilateral salpingo-oophorectomy ± pelvic lymphadenectomy.\n   * good performance status : ECOG 0, 1, 2\n   * patients who provide informed written consent to participate in the study.\n2. Exclusion criteria:\n\n   * severe cardiopulmonary diseases (e.g unstable angina, severe COPD).\n   * Absolute contraindication to laparoscopy.\n   * stage Ⅲ and Ⅳ endometrial cancer.\n   * patients who received previous pelvic radiotherapy.\n   * patients who underwent prior lymphadenectomy.","FEMALE",{"count":47,"type":20},48,"INTERVENTIONAL",[50],"NA","Endometrial cancer is one of the most common gynecological malignancies worldwide. Surgical staging is the cornerstone of management and traditionally performed via laparotomy. However, minimally invasive surgery, particularly laparoscopy, has emerged as an effective alternative with potential benefits in reducing postoperative morbidity.\n\nThis study aims to compare the outcomes of laparoscopic versus open (laparotomy) surgical staging in patients with endometrial cancer in low-resource settings. Primary aim: To compare early postoperative recovery after surgical staging for early-stage endometrial cancer between laparoscopic and open approaches, assessed primarily by time to ambulation.\n\n• Secondary aim: To compare intraoperative outcomes (operative time, blood loss, lymph node yield), postoperative morbidity (Clavien-Dindo classification), quality of recovery (QoR-15), length of hospital stay, same day discharge(SDD), discrepancy between preoperative curettage pathology and final histopathology, delay in initiation of adjuvant therapy, one-year disease-free survival, direct hospital costs between both approaches, and quality of life using EQ-5D-5L questionnaire.\n\nGiven the limited resources and variations in surgical expertise in low-resource settings, this study seeks to evaluate the feasibility, safety, and effectiveness of laparoscopy compared to laparotomy. The findings may help guide clinical decision-making and optimize surgical approaches in similar healthcare environments.",[53,54,25],"Gynaecological Oncology","Gynaecological Malignancies","RECRUITING","2026-06-06",{"date":58,"type":30},"2026-06-10",{"date":60,"type":30},"2026-06-02",{"date":62,"type":20},"2028-10-01",{"name":64,"class":37},"Assiut University",1,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":48,"phases":76,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":65},"100578406","intravenous-versus-perineural-ondansetron-for-laparoscopic-sleeve-gastrectomy-100578406","NCT06810882","Intravenous Versus Perineural Ondansetron for Laparoscopic Sleeve Gastrectomy","Intravenous Versus Perineural Ondansetron as an Adjuvant in Autonomic Neural Blockade for Laparoscopic Sleeve Gastrectomy: A Two-Center, Randomized, Double-Blind, Non-inferiority Trial","Inclusion Criteria:\n\n* Patients of either sex\n* American Society Anesthesiologists physical (ASA) status II-III\n* age between 18-65 years old\n* Body mass index (BMI) \\>35 kg\u002Fm2 with comorbidity or \\> 40 kg\u002Fm2 -- undergoing laparoscopic sleeve gastrectomy with intraoperative surgeon performed laparoscopic paragastric autonomic neural blockade..\n\nExclusion Criteria:\n\n* Allergy to experimental drugs.\n* Known to have long QT, previous history of postoperative nausea and vomiting\n* Abuse of alcohol, analgesia, or sedative antidepressant drugs\n* Chronic pain disorders\n* History of previous upper gastrointestinal system surgery, those with surgery-related complications during or after surgery.\n* Liver or kidney failure\n* Performance of concomitant procedures in addition to laparoscopic sleeve gastrectomy\n* Anesthetic complications that may alter the postoperative management protocol.","65 Years",{"count":75,"type":20},482,[50],"This prospective randomized non-inferiority study will be conducted to compare the analgesic anti-emetic effects of intravenous ondansetron versus perineural ondansetron in patients undergoing laparoscopic sleeve gastrectomy.",[79,25,80],"Ondansetron","Gastrectomy",[79,25,80],"2026-05-13",{"date":84,"type":30},"2026-05-15",{"date":86,"type":30},"2025-02-16",{"date":88,"type":20},"2027-02-17",{"name":90,"class":37},"Tanta University",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":48,"phases":101,"briefSummary":102,"conditions":103,"keywords":107,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":65},"100404428","low-thoracic-epidural-anesthesia-for-laparoscopic-nephrectomy-100404428","NCT04546230","Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy.","Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy In Adult Patients.","Inclusion Criteria:\n\n* ASA I - II.\n* Adult patients scheduled for laparoscopic nephrectomy.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Contraindication to regional anesthesia (e.g., coagulopathy, site infection).\n* Allergy to local anesthetics.","70 Years",{"count":100,"type":20},80,[50],"Laparoscopic nephrectomy is a surgical technique to excise a diseased kidney. It's a minimally invasive technique, so when compared to open surgery, it can mean significantly less post-operative pain, shorter hospital stay, earlier return to work and daily life activities, a more favourable cosmetic result and outcomes similar to that of open surgery.\n\nRecently, advanced laparoscopic surgery has targeted older and high risk patients for general anesthesia; in these patients, regional anesthesia offers several advantages with improved patient satisfaction. Compared with alternative anesthetic techniques, epidural anesthesia may reduce the risks of venous thromboembolism, myocardial infarction, bleeding complications, pneumonia, respiratory depression and renal failure.\n\nThe aim of this study is to compare the conventional general anesthetic technique to the regional anesthesia for laparoscopic nephrectomy, in modified lateral decubitus position using low-pressure pneumoperitoneum.",[25,104,105,106],"Nephrectomy","Anesthesia","Epidural",[108,109,110],"Epidural Anesthesia","Low-thoracic","Laparoscopic nephrectomy","2026-01-08",{"date":113,"type":30},"2026-01-12",{"date":115,"type":30},"2020-09-19",{"date":117,"type":20},"2026-12",{"name":119,"class":37},"Nazmy Edward Seif",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":48,"phases":129,"briefSummary":130,"conditions":131,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":4},"100602000","feasibility-and-safety-of-laparoscopic-purse-string-suture-clamp-and-multi-functional-seal-cap-for-totally-laparoscopic-radical-total-gastrectomy-100602000","NCT07117812","Feasibility and Safety of Laparoscopic Purse-string Suture Clamp and Multi-functional Seal Cap for Totally Laparoscopic Radical Total Gastrectomy","Inclusion Criteria:\n\n* Age 18-80 years, regardless of gender; Histologically confirmed gastric or gastroesophageal junction (GEJ) adenocarcinoma. For GEJ cancer, only Siewert type III and type II (without requiring thoracotomy) are eligible (applicable to multiple primary cancers); Preoperative assessment by a gastrointestinal surgeon and imaging specialist confirming cStage I-III disease with eligibility for curative-intent R0 resection. Patient consents to surgery and is deemed surgically fit by the surgeon; Anticipated R0 resection achievable via total gastrectomy with D1+\u002FD2 lymphadenectomy; Expected survival ≥6 months; ECOG Performance Status (PS) score (see Appendix 2) of 0 or 1; Adequate major organ function; Body weight ≥40 kg or BMI \\>18.5 and \\\u003C30 kg\u002Fm²; No prior chemotherapy, radiotherapy, targeted therapy, or immunotherapy; Patient has read and fully understood the informed consent form and voluntarily signed it\n\nExclusion Criteria:\n\n* History of other active malignancies within the past 5 years or concurrent malignancies (except cured localized tumors such as basal cell carcinoma, squamous cell carcinoma of the skin, superficial bladder cancer, carcinoma in situ of the prostate\u002Fcervix\u002Fbreast, Stage I lung\u002Fcolorectal cancer, etc.).\n\nPrevious upper abdominal surgery (excluding laparoscopic cholecystectomy). History of gastrectomy, endoscopic mucosal resection (EMR), or endoscopic submucosal dissection (ESD).\n\nRequirement for concurrent surgery for other diseases. Emergency surgery due to gastric cancer complications (bleeding, obstruction, or perforation).\n\nPlanned or prior organ\u002Fbone marrow transplantation. Blood transfusion within 2 weeks before surgery, bleeding history, or Grade ≥3 hemorrhage (CTCAE v4.0) within 4 weeks.\n\nCoagulopathy (INR \\>1.5 without anticoagulants) or use of anticoagulants (warfarin\u002Fheparin). Prophylactic low-dose warfarin (≤1 mg\u002Fday) or aspirin (≤100 mg\u002Fday) is permitted if INR ≤1.5.\n\nArterial\u002Fvenous thrombosis within 6 months (e.g., stroke, DVT, pulmonary embolism), excluding catheter-related thrombosis from prior chemotherapy.\n\nMyocardial infarction within 6 months or uncontrolled arrhythmia (QTc ≥450 ms \\[men\\]\u002F≥470 ms \\[women\\] by Fridericia's formula).\n\nNYHA Class III-IV heart failure or LVEF \\\u003C50%. Ventilatory dysfunction (FEV1 \\\u003C50% predicted). Urinary protein ≥++ or 24-hour urine protein \\>1.0 g. Clinically significant pleural\u002Fperitoneal effusion requiring intervention. HIV infection. Active tuberculosis. Non-healing wounds or incomplete fracture healing. Active\u002Fsuspected autoimmune disease (stable cases without immunosuppressants allowed).\n\nSevere autoimmune diseases (e.g., SLE, IBD), chronic diarrhea disorders, or active HBV\u002FHCV (HBV DNA \\\u003C500 copies\u002FmL permitted).\n\nSystemic corticosteroids (\\>10 mg\u002Fday prednisone equivalent) within 14 days (topical\u002Finhaled steroids or physiologic replacement doses allowed).\n\nActive infection requiring systemic antibiotics within 14 days (prophylactic antibiotics permitted).\n\nLive vaccines within 28 days (inactivated flu vaccines allowed). Concurrent participation in another surgical trial. Alcohol\u002Fdrug abuse history (abstinent patients eligible). Non-compliance or incomplete data affecting safety\u002Fefficacy assessments. Pregnancy\u002Flactation. Other conditions deemed high-risk by investigators. Investigator-determined ineligibility.","80 Years",{"count":128,"type":20},50,[50],"Currently, there are three main methods for endoscopic esophagojejunostomy: circular, linear, and hand-sewn anastomosis, but no universally accepted optimal approach has been established.\n\nHand-sewn anastomosis relies on advanced endoscopic suturing skills, making it technically demanding and only performed in a limited number of hospitals.\n\nLinear anastomosis is simple to perform and the most widely used in clinical practice. However, it requires resection of a longer segment of the distal esophagus and may struggle to ensure adequate margins for high-positioned tumors or unclear resection boundaries.\n\nCircular anastomosis is a classic method. Its end-to-side approach preserves more esophageal length, making it suitable for high-positioned tumors without the need to close a common opening. Various techniques (e.g., the reverse-puncture method and the Orvil™ transoral anvil technique) have been reported. However, due to challenges such as purse-string suturing, complex anvil placement, and restricted stapler maneuverability, widespread adoption remains difficult.\n\nProf. Du Jianjun's team innovatively employed endoscopic purse-string forceps and a multifunctional sealing ring to achieve circular anastomosis, demonstrating preliminary technical advantages. This study further explores its feasibility and short-term outcomes in totally endoscopic total gastrectomy.",[132,80,133,25],"Gastric Cancer (GC)","Anastomosis, Roux-en-Y","2025-08-12",{"date":136,"type":30},"2025-08-15",{"date":138,"type":20},"2025-09-01",{"date":140,"type":20},"2027-09-01",{"name":142,"class":37},"The First Affiliated Hospital with Nanjing Medical University",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":150,"sex":45,"minAge":17,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":48,"phases":153,"briefSummary":154,"conditions":155,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":65},"100554837","low-versus-standard-pressure-pneumoperitoneum-on-shoulder-tip-pain-100554837","NCT06504277","Low Versus Standard Pressure Pneumoperitoneum on Shoulder Tip Pain","A Randomized Controlled Trial (RCT) Comparing the Effect of Low Versus Standard Pressure Pneumoperitoneum on Post-operative Shoulder Tip Pain in Patients Undergoing Laparoscopic Gynecologic Surgery for Benign Indications","Inclusion Criteria: The participant must meet all of the inclusion criteria to eligible for this clinical trial:\n\n1. All ages \\> or = to 18 years old;\n2. Must be deemed to have capacity to provide informed consent;\n3. Must sign and date the informed consent form;\n4. Stated willingness to comply with all study procedures;\n5. Must be undergoing unilateral or bilateral salpingo-oopherectomy or salpingectomy or ovarian cystectomy;\n\nExclusion Criteria: An individual who meets any of the following criteria will be excluded from participation in this clinical trial:\n\n1. Previous midline laparotomy;\n2. Gynecological cancer beyond stage 1 disease;\n3. Chronic pain;\n4. Known diagnosis of endometriosis or evidence of endometriosis intra-operatively;\n5. Fibromyalgia;\n6. BMI \\>50;\n7. Language barrier;\n8. Inability to communicate or provide informed consent;",true,{"count":152,"type":20},82,[50],"This proposed study is a single-center, double blind, parallel group RCT comparing the use of low (10 mm Hg) versus standard pressure (15 mm Hg) pneumoperitoneum at the time of benign gynecologic laparoscopic surgery. Patients will be randomized to the control group (standard pressure) or the intervention group (low pressure) and surgeons will be blinded to the study pressure. Data on post-operative recovery and pain scores will be recorded for each patient.",[156,25,157,158,159,160],"Surgery","Laparoscopy","Penumoperitoneum","Post-operative Pain","Post-operative Recovery","2025-07-28",{"date":163,"type":30},"2025-07-31",{"date":165,"type":30},"2025-07-02",{"date":167,"type":20},"2026-09-15",{"name":169,"class":37},"Mount Sinai Hospital, Canada",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":177,"enrollmentInfo":178,"targetDuration":4,"studyType":48,"phases":180,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":65},"100385189","reduced-port-laparoscopic-gastrectomy-for-gastric-cancer-100385189","NCT04295473","Reduced Port Laparoscopic Gastrectomy for Gastric Cancer","Comparison the Short and Long-term Outcome of Patients With Gastric Cancer Who Underwent Reduced Port Laparoscopic Gastrectomy With Patients Underwent Traditional Laparoscopic Gastrectomy","Inclusion Criteria:\n\n1. Histologically confirmed adenocarcinoma of the stomach, T1-T4 stages.\n2. Eastern Cooperative Oncology Group performance status of 0 or 1.\n3. Adequate organ function.\n\nExclusion Criteria:\n\n1. Patients had distant metastasis.\n2. oesophageal invasion of more than 3 cm.\n3. Borrmann type 4 or large (more than 8 cm) type 3 carcinoma.\n4. Previous chemotherapy or radiation therapy for any other malignancies.","90 Years",{"count":179,"type":20},160,[50],"Reduced port laparoscopic gastrectomy has been adopted in clinical. The safety and outcome of reduced port laparoscopic gastrectomy has not been systematically evaluated. The investigators sought to compare the short and long-term outcome of patients with gastric cancer who underwent reduced port gastrectomy with patients underwent traditional laparoscopic gastrectomy",[25,80],"2025-05-16",{"date":185,"type":30},"2025-05-21",{"date":187,"type":30},"2020-03-02",{"date":189,"type":20},"2027-03-01",{"name":191,"class":192},"Nanchong Central Hospital","OTHER_GOV",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":150,"sex":16,"minAge":17,"maxAge":126,"enrollmentInfo":199,"targetDuration":4,"studyType":48,"phases":201,"briefSummary":202,"conditions":203,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":4},"100535937","mesh-fixation-versus-non-fixation-in-laparoscopic-inguinal-hernioplasty-100535937","NCT06258317","Mesh Fixation Versus Non Fixation in Laparoscopic Inguinal Hernioplasty","Inclusion Criteria:\n\n* Any male or female above 18 years old that has uncomplicated inguinal hernia\n\nExclusion Criteria:\n\n* Patients with contraindications to use laparoscopy as cardiac or immunocompromised patients.\n* Patients who are difficult to follow up.",{"count":200,"type":20},30,[50],"Inguinal hernia is one of the most common types of abdominal hernias. Laparoscopic hernioplasty of inguinal hernia is a good alternative to traditional open repairs even in simple unilateral primary inguinal hernia in terms of decrease post operative pain and complications with comparable recurrence rates.Two techniques are described in laparoscopic hernioplasty and have been extensively studied in randomised trials. The totally extraperitoneal (TEP) approach is more widely used than the transabdominal preperitoneal (TAPP) approach.\n\nIn this study we will compare between the results of mesh fixation and non fixation as regard operative and postoperative data.",[25,204,205],"Inguinal Hernia","Hernioplasty","2024-02-12",{"date":208,"type":30},"2024-02-14",{"date":210,"type":20},"2024-02",{"date":212,"type":20},"2027-03",{"name":64,"class":37},{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":221,"enrollmentInfo":222,"targetDuration":4,"studyType":48,"phases":224,"briefSummary":225,"conditions":226,"keywords":229,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":65},"100346055","comparing-laparoscopic-and-open-surgery-for-pancreatic-carcinoma-100346055","NCT03785743","Comparing Laparoscopic and Open Surgery for Pancreatic Carcinoma","Total Laparoscopic Pancreaticoduodenectomy Versus Open Pancreaticoduodenectomy for Pancreatic Carcinoma(TJDBPS07) a Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age between 18 years and 75 years.\n2. Histologically confirmed PDAC or clinically diagnosed PDAC by an MDT without histopathologic evidence.\n3. Patients feasible to undergo both LPD and OPD according to MDT evaluations.\n4. Patients understanding and willing to comply with this trial.\n5. Provision of written informed consent before patient registration.\n6. Patients meeting the curative treatment intent in accordance with clinical guidelines.\n\nExclusion Criteria:\n\n1. Patients with distant metastases, including peritoneal, liver, distant lymph node metastases, and involvement of other organs.\n2. Patients requiring left, central or total pancreatectomy or other palliative surgery.\n3. Preoperative American Society of Anaesthesiologists (ASA) score ≥ 4.\n4. History of other malignant disease.\n5. Pregnant or breast-feeding women.\n6. Patients with serious mental disorders.\n7. Patients treated with neoadjuvant therapy.\n8. Patients with vascular invasion and requiring vascular resection as evaluated by the MDT team according to abdominal imaging data.\n9. Body mass index \\> 35 kg\u002Fm2.\n10. Patients participating in any other clinical trials within 3 months.","75 Years",{"count":223,"type":20},200,[50],"Background: Pancreatic cancer (PC) is one of the most aggressive malignant neoplasms with poor outcomes. Pancreatoduodenectomy (PD) is the only curative treatment for PC. Minimally invasive surgery has been progressively developed, first with the advent of hybrid-laparoscopy and recently with the total laparoscopy surgeries, but a number of issues are currently being debated, including the superiority between total laparoscopic pancreaticoduodenectomy (TLPD)and the open pancreaticoduodenectomy (OPD). Studies comparing these two surgery techniques are merging and randomized controlled trials (RCT) are lacking but clearly required.\n\nMethods\u002Fdesign: TJDBPS07 is a multicenter prospective, randomized controlled, trial comparing TLPD and OPD in pancreatic cancers. A total of 200 patients with pancreatic cancer underwent PD will be randomly allocated to the TLPD group or OPD group with an enhanced recovery after surgery (ERAS) pattern. The trial's aim is to exploring the overall survival (OS), disease free survival (DFS) and quality of life. The duration of the entire trial is seven years including prearrangement, a presumably five-year follow-up and analyses.\n\nDiscussion: Despite the fact there are several RCTs comparing minimally invasive pancreaticoduodenectomy (MIPD) and Open approach or LPD versus OPD. This trial will be the first comparing TLPD and OPD in a large multicenter setting. TJDBPS01 trial is hypothesized to assess whether TLPD has superiority over OPD in recovery and other aspects.",[227,25,228],"Pancreatic Carcinoma","Pancreaticoduodenectomy",[227,25,228,230],"Survival","2022-02-27",{"date":233,"type":30},"2022-03-02",{"date":235,"type":30},"2019-03-01",{"date":237,"type":20},"2027-05-01",{"name":239,"class":37},"Tongji Hospital"]