[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"large-basal-ganglia-hemorrhage\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:large-basal-ganglia-hemorrhage":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100553306","a-multicenter-randomlzed-controlled-umbrella-trial-for-minimally-invasive-neurosurgery-with-al-assisted-robotic-guidance-for-hemorrhagic-stroke-large-basal-ganglia-hemorrhage-100553306",false,"NCT06484374","A Multicenter, RAndomlzed, coNtrolled, umBrella Trial fOr Minimally Invasive Neurosurgery With Al-assisted Robotic guidanCe for Hemorrhagic Stroke: Large Basal Ganglia Hemorrhage","RAINBOW-LBH","Inclusion Criteria:\n\n1. Age ≥18 years at randomization;\n2. Diagnosed with hypertensive basal ganglia hemorrhage via imaging (CT, CTA, etc.);\n3. Hematoma volume ≥30 mL prior to randomization;\n4. Glasgow Coma Scale (GCS) score ≥ 5;\n5. Available for surgery within 72 hours after onset;\n6. Modified Rankin Scale (mRS) score ≤ 1 prior to this hemorrhage;\n7. Informed consent obtained in accordance with national laws, regulations, and applicable ethics committee requirements.\n\nExclusion Criteria:\n\n1. Hematoma involving the thalamus (volume \\>5 mL or diameter \\>2 cm), midbrain, or ventricles (Graeb score ≥3), or other locations;\n2. Radiologically confirmed cerebral vascular abnormalities including ruptured aneurysms, arteriovenous malformations (AVMs), or Moyamoya disease; hemorrhagic transformation of ischemic infarcts; or recent (within 1 year) recurrence of intracerebral hemorrhage;\n3. Signs of impending herniation such as midline shift exceeding 1 cm or ipsilateral pupillary changes;\n4. Any irreversible coagulation disorder or known coagulopathy; platelet count \\\u003C100,000; INR \\>1.4; or use of anticoagulant medication within 7 days before the current hemorrhage;\n5. Current or probable pregnancy;\n6. Patients with concurrent severe illness likely to influence outcome assessment;\n7. Difficulty in follow-up or poor compliance due to any cause.","ALL","18 Years",{"count":19,"type":20},198,"ESTIMATED","INTERVENTIONAL",[23],"NA","This substudy is a prospective, multicenter, parallel-controlled, randomized controlled trial designed to evaluate whether robot-assisted endoscopic evacuation of large basal ganglia hematomas can improve patient outcomes compared with traditional surgical approaches such as small craniotomy or large-bone-flap intracranial hematoma evacuation.",[26,27],"Hematoma Brain","Large Basal Ganglia Hemorrhage",[27,29,30,31,32,33],"Al-assisted robotic guidance","multicenter","Randomlzed","controlled","umbrella trial","RECRUITING","2026-02-12",{"date":37,"type":38},"2026-02-17","ACTUAL",{"date":40,"type":38},"2025-12-20",{"date":42,"type":20},"2027-12-31",{"name":44,"class":45},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","OTHER"]