[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"laryngeal-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:laryngeal-disease":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,50,103,126,146,173,207,235],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100318690","biospecimen-procurement-for-head-and-neck-disorders-100318690",false,"NCT03429036","Biospecimen Procurement for Head and Neck Disorders","Biospecimen Procurement for the Study of Head and Neck Disorders","* INCLUSION CRITERIA:\n* Age 3 and older.\n* Able to provide their own consent, or for minors, a parent or guardian is able to consent on their behalf.\n* Diagnosis of a condition of the head and neck for which removal of biological specimens was indicated for clinical care or for research purposes under a separate Review Board (IRB) approved protocol.\n* Ability of subject (or Legally Authorized Representative (LAR)) to understand and the willingness to sign a written informed consent document.\n\nEXCLUSION CRITERIA:\n\n* Part 1:\n\n  --Are unwilling to share waste specimens for research purposes\n* Part 2: Additional exclusion criteria for the Part 2 prospective sample collection part of this protocol these criteria may be assessed prior to collection of the samples but will not affect overall eligibility for the trial (i.e., Part 1):\n\n  * have active symptomatic major organ disorders that would increase the risk of biopsy for research, including but not limited to bleeding disorders, ischemic heart disease, a recent myocardial infarction, active congestive heart failure or severe pulmonary dysfunction\n  * have specific medical condition, such as a bleeding tendency where additional biopsies or phlebotomy procedures may increase the participants risk in participating. This will be determined at the discretion of the principal investigator\n  * Individuals under the age of 18 are excluded from oral mucosal biopsies and skin biopsies","ALL","3 Years","120 Years",{"count":20,"type":21},1000,"ESTIMATED","OBSERVATIONAL","Background:\n\nResearchers want to learn more about head and neck disorders. Understanding these disorders could help them find better treatments. To do this, they are collecting tissue samples for research.\n\nObjective:\n\nTo create a repository of tissue samples and data to better study conditions of the head and neck.\n\nEligibility:\n\nPeople who had or will have tissue samples taken because of a head or neck disorder. They must be ages 3 and older and not pregnant to join Part 2.\n\nDesign:\n\nParticipants will be screened with a questionnaire, medical history, and physical exam.\n\nPart 1. Participants will give permission for any of their tissue samples leftover from private care or other research protocols to be used.\n\nIf participants tissue did not contain normal tissue or if they have a condition that suggests a genetic issue, they will be invited to join Part 2.\n\nPart 2: Participants will have additional samples collected. These could be:\n\n* Blood: Blood is drawn through a needle in the arm.\n* Cheek swab or brushing: A cotton swab or small brush is rubbed inside the cheek.\n* Saliva: They rinse their mouth with water and spit into a tube or cup.\n* Skin biopsy: They are injected with a numbing drug. A biopsy tool removes a small piece of skin.\n* Mucosal biopsy: They are injected in the mouth with a numbing medication. A small piece of tissue from the inside of the cheek is removed.\n\nParticipants samples will be used for future research, including genetic testing.",[25,26,27,28,29],"Hearing Disorder","Oral Mucosal Disease","Pharyngeal Neoplasm","Head and Neck Neoplasms","Laryngeal Disease",[31,32,33,34,35,36],"Genomic DNA","DNA Banking","Tissue Sample","Saliva","Blood Collection","Natural History","RECRUITING","2026-06-10",{"date":40,"type":41},"2026-06-11","ACTUAL",{"date":43,"type":41},"2018-05-23",{"date":45,"type":21},"2029-12-02",{"name":47,"class":48},"National Cancer Institute (NCI)","NIH",9,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":72,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":102},"100562265","effect-of-passive-music-therapy-via-an-app-on-anxiety-prevention-in-ent-surgery-100562265","NCT06600919","Effect of Passive Music Therapy Via an App on Anxiety Prevention in ENT Surgery","MUSICORL","Inclusion Criteria:\n\n* Male or female, aged 18 years or older\n* Patient has signed informed consent\n* Patient scheduled to undergo ENT surgery (cervical, endonasal, otologic, oropharyngeal-laryngeal) at the participating facility\n* Patient is affiliated with or a beneficiary of a social security system\n\nExclusion Criteria:\n\n* Refusal to provide consent\n* Patient with severe bilateral hearing loss (\\> 70 dB HL)\n* Patient unable to read, write, or understand French\n* Vulnerable patient as defined by Article L1121-6 of the French Public Health Code (CSP)\n* Adult patient under guardianship, curatorship, or judicial protection\n* Patient unable to personally provide consent as per Article L1121-8 of the CSP or an adult under legal protection\n* Pregnant or breastfeeding women as per Article L1121-5 of the CSP\n* Patient who has already participated in the current study","18 Years",{"count":59,"type":21},500,"INTERVENTIONAL",[62],"NA","Music therapy is a controlled method of listening to music, utilizing its physiological, psychological, and emotional effects on humans during the treatment of illness or trauma. It is considered active when it involves playing musical instruments and passive when it involves listening to music (via headphones, television, stereo systems, etc.).\n\nThe benefits of this technique in treating chronic pain (i.e., pain lasting several weeks, such as chronic back pain, osteoarthritis, etc.) have been demonstrated. Numerous studies have also examined the effect of music therapy on acute postoperative pain and anxiety related to surgical interventions. These studies suggest, though without conclusive evidence, that a single session of music therapy just before entering the operating room may reduce postoperative pain and anxiety.\n\nHowever, all of these studies were limited by relatively small sample sizes (a few hundred patients), leaving some scientific uncertainty regarding the effectiveness of music therapy in the context of surgical interventions.\n\nThis research will therefore evaluate the impact of preoperative passive music therapy on perioperative anxiety and postoperative pain, with a larger number of patients included in the study than has been previously reported in the scientific literature.\n\nThe primary objective of this study is to assess the impact of preoperative passive music therapy on perioperative anxiety in patients undergoing ENT surgery. MUSICORL is an interventional, randomized study (the assignment to receive or not receive music therapy will be determined by randomization) with two parallel arms. This is a single-center study, conducted at a single French site: Clinique Saint Vincent. A total of 500 subjects will participate in this study. Your participation will last for 2 days; the overall study duration will be 27 months.\n\nTo participate in this research, you must be affiliated with a social security system, be over 18 years old, have signed informed consent, and be scheduled for ENT surgery (cervical, endonasal, otologic, oropharyngeal-laryngeal).",[65,66,67,68,29,69,70,71],"Cervical Surgery","Endonasal Surgery","Otologic Disease","Oropharyngeal Disease","ENT Surgery","Musical Therapy","Laryngeal Surgery",[73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91],"Music therapy","Preoperative anxiety","ENT surgery","Passive music therapy","Randomized controlled trial","Perioperative anxiety","Postoperative pain","Patient care improvement","Clinical research","Music Care® application","Music Care®","Surgical intervention","Anxiety prevention","Music therapy session","Cervical surgery","Endonasal surgery","Otologic surgery","Oropharyngolaryngeal surgery","Musical therapy","2026-03-17",{"date":94,"type":41},"2026-03-18",{"date":96,"type":41},"2024-11-15",{"date":98,"type":21},"2027-02",{"name":100,"class":101},"Clinique Saint-Vincent","OTHER",1,{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":60,"phases":112,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":102},"100626357","force-sensor-study-100626357","NCT07434583","Force Sensor Study","Biomechanical Analysis of Force Loadings During Suspension Microlaryngoscopy","Inclusion Criteria:\n\n* \\>18 years old with\n* undergoing laryngeal surgery with direct laryngoscopy\n\nExclusion Criteria:\n\n* Prior history of tongue dysfunction such as glossectomy (hemi or total) or hypoglossal nerve injury\n* Patient inability to follow up after initial procedure",{"count":111,"type":21},100,[62],"This research is to understand more about the forces that are involved on the tongue and other oropharyngeal structures during laryngeal surgery. This information will be used to determine if these forces can affect outcomes (pain, numbness, taste, etc) and whether factors such as procedure type, surgeon experience (i.e. resident, fellow, attending), and choice of surgical equipment affect these forces. This information may be used to reduce these forces and prevent these issues from happening during certain laryngeal surgeries.\n\nFor the first 50 patients, force measurements will be taken and correlated to outcome measures . Surgeons will be blinded to the force measurements intra-operatively.\n\nFor the next 50 patients, surgeons will be given force measurements in real-time intra-operatively allowing adjustments to be made. The impact of this adjustment on outcomes will be determined.",[29,115,116],"Post-operative Pain","Tongue Injury","2026-02-19",{"date":119,"type":41},"2026-02-25",{"date":121,"type":41},"2026-01-02",{"date":123,"type":21},"2027-01-31",{"name":125,"class":101},"University of California, San Francisco",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":134,"conditions":135,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":102},"100618033","ai-system-for-anatomic-recognition--lesion-detection-in-nasopharyngolaryngoscopy-a-prospective-study-100618033","NCT07326358","AI System for Anatomic Recognition & Lesion Detection in Nasopharyngolaryngoscopy: A Prospective Study","Development and Validation of an Artificial Intelligence System for Anatomic Site Recognition and Lesion Detection Based on Electronic Nasopharyngolaryngoscopic Images: A Prospective Multicenter Study","Inclusion Criteria:\n\n* Age ≥ 18 years;\n* Underwent standard electronic nasopharyngolaryngoscopy;\n* Patients who underwent biopsy sampling have a clear pathological diagnosis;\n* Signed a written informed consent form.\n\nExclusion Criteria:\n\n* Image quality is substandard with severe motion artifacts;\n* Lesion images are unclear and incomplete.",{"count":59,"type":21},"An artificial intelligence-assisted system is trained and validated by collecting nasopharyngolaryngoscopy images from patients.",[136,29],"Nasopharyngeal Neoplasms","2025-12-26",{"date":139,"type":41},"2026-01-08",{"date":141,"type":41},"2025-12-12",{"date":143,"type":21},"2027-03-31",{"name":145,"class":101},"Ruijin Hospital",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":152,"enrollmentInfo":153,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":154,"conditions":155,"keywords":158,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":102},"100539387","nidcd-otolaryngology-clinical-protocol-biospecimen-bank-100539387","NCT06303180","NIDCD Otolaryngology Clinical Protocol Biospecimen Bank","* INCLUSION CRITERIA\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Ability to provide their own consent, or for minors, a parent or guardian is able to consent on their behalf.\n* Ability of subject (or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document.\n* Have a hearing, balance, smell, taste, voice, speech or language condition for which the subject is under clinical care or research purposes under a separate Review Board (IRB) approved protocol; OR be a healthy volunteer aged at least 3 years, enrolled on an approved research protocol.\n\nEXCLUSION CRITERIA\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n* Have active symptomatic major organ disorders that would increase the risk of biopsy for research, including but not limited to bleeding disorders, ischemic heart disease, a recent myocardial infarction, active congestive heart failure or severe pulmonary dysfunction\n* Have specific medical condition, such as a bleeding tendency where additional biopsies or phlebotomy procedures may increase the subjects risk in participating. This will be determined at the discretion of the principal investigator.","99 Years",{"count":20,"type":21},"Background:\n\nMany disorders of the head and neck can affect a person s hearing; balance; smell; taste; swallowing; voice; or speech. These disorders include cancers and genetic and inflammatory diseases. To find better ways to diagnose and treat these disorders, researchers need to study tissues and other biological samples from people who have them.\n\nObjective:\n\nTo collect biological samples for a repository that will be used for research.\n\nEligibility:\n\nPeople of any age with a disorder of the head and neck that requires the taking of biological samples. The conditions may be any that affect hearing; balance; smell; taste; swallowing; voice; or speech.\n\nDesign:\n\nPart 1: Participants will give permission for their leftover tissue samples to be used for research. These are tissue samples from the head and neck that were collected in the course of routine tests and care or other research studies. Information on each participant s age, diagnosis, and previous treatments will also be collected.\n\nPart 2: Some participants may be asked for more samples. All those aged 3 years or older will have a physical exam. They will provide blood and saliva samples. A cotton swab or brush will be used to collect cells from the inside of the cheek.\n\nParticipants 18 years or older may have additional tests. They may provide nasal secretions: A piece of gelfoam or a sponge will be placed in the nose to soak up secretions for 5 to 10 minutes. They may have biopsies: Small samples of tissue will be cut from the skin and the tissue lining the mouth.\n\nSamples may be used for genetic testing.",[156,28,157,29],"Hearing Loss","Hearing Disorders",[159,160,161,162,163,33,31,34],"Hearing","Balance","Speech","Taste","SMELL","2025-11-13",{"date":166,"type":41},"2025-11-14",{"date":168,"type":41},"2024-03-04",{"date":170,"type":21},"2033-12-30",{"name":172,"class":48},"National Institute on Deafness and Other Communication Disorders (NIDCD)",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":180,"enrollmentInfo":181,"targetDuration":4,"studyType":60,"phases":183,"briefSummary":184,"conditions":185,"keywords":194,"overallStatus":198,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":102},"100522123","assessment-of-laryngopharyngeal-sensation-cancer-survivor-cohort-100522123","NCT06078527","Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort","Assessment of Laryngopharyngeal Sensation in Patients With Laryngopharyngeal Disorders","Inclusion Criteria:\n\n1. Age \\\u003C=18 years.\n2. Individuals without a laryngopharyngeal disorder (health controls) or with a laryngopharyngeal disorder. Laryngopharyngeal disorder includes but is not limited to: presbylarynx, aspiration; spasmodic dysphonia; globus pharynges; vocal fold paralysis; iatrogenic injury to the larynx; muscle tension dysphonia; neurogenic dysphagia; laryngeal sensory neuropathy; and laryngopharyngeal disorders resulting from prior radiation therapy in individuals with a history of head and neck cancer who have completed radiation therapy as primary or adjuvant cancer treatment\n3. Ability and willingness to comply with study procedures.\n4. Ability to understand a written informed consent document, and the willingness to sign it.\n\nExclusion Criteria:\n\n1. Non-English speaking.\n2. Laryngopharyngeal structures are not accessible on exam.\n3. Known contraindication to any study-related procedure, or history of being unable to tolerate laryngoscopy.\n4. Vocal fold immobility or severe hypomobility on adduction.\n5. For head and neck cancer survivors only: Currently undergoing radiation therapy for head and neck cancer (i.e., primary\u002Fadjuvant radiation therapy treatment plan is not yet completed).","85 Years",{"count":182,"type":21},40,[62],"A previous study completed in 2022 (NCT05158179) was conducted using cohorts of healthy controls, and adults with general laryngopharyngeal disorders. This study will expand on the previous research to include a separate cohort of adults being seen in clinic for an existing laryngopharyngeal disorder resulting from previous radiation or other cancer treatments.",[186,187,188,189,190,29,191,192,193],"Presbylarynx","Aspiration","Spasmodic Dysphonia","Globus Pharyngeus","Larynx Paralysis","Vocal Cord Paralysis","Iatrogenic Injury","Sensory Neuropathy",[195,196,197],"Cancer survivors","Previous cancer treatment","Laryngopharyngeal disorders","NOT_YET_RECRUITING","2025-07-21",{"date":201,"type":41},"2025-07-23",{"date":203,"type":21},"2025-10-01",{"date":205,"type":21},"2028-01-31",{"name":125,"class":101},{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":4,"eligibilityCriteria":213,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":214,"targetDuration":4,"studyType":60,"phases":215,"briefSummary":217,"conditions":218,"keywords":221,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":102},"100564872","early-phase-1-efficacy-of-intramuscular-steroid-injection-for-chronic-cough-100564872","NCT06634823","Efficacy of Intramuscular Steroid Injection for Chronic Cough.","Prospective Placebo-Controlled Trial of Intramuscular Steroid Administration for the Treatment of Unexplained Chronic Cough","Inclusion Criteria:\n\n* History consistent with chronic unexplained or refractory cough\n* Age ≥ 18\n\nExclusion Criteria:\n\n* Current smokers\n* Uncontrolled diabetes (A1c\\>7%)\n* Patients on ACE inhibitors or Angiotensin II receptor blockers (ARBs)\n* Abnormal pulmonary function testing (PFTs) since start of the cough\n* Patients with uncontrolled obstructive sleep apnea\n* Abnormal chest X-ray within past 6 months\n* Uncontrolled reflux\n* Prior superior laryngeal nerve injection\n* Current neuromodulating medication use for chronic cough\\*",{"count":182,"type":21},[216],"EARLY_PHASE1","The primary goal of this study is to test the hypothesis that injecting steroid intramuscularly is an effective treatment for unexplained chronic cough. This will be achieved through the design of a prospective, placebo-controlled, single-blind, randomized clinical trial in which one group of patients will undergo a steroid injection into the deltoid muscle and the second group will undergo a placebo injection into the deltoid muscle. Data to determine if a clinically significant difference exists between the outcomes of the two groups will be measured by a dichotomous yes\u002Fno response to improvement, the Leicester Cough Questionnaire, and a visual analogue scale for symptom severity. This will provide the answer to the general question of whether or not the intramuscular injections are clinically effective for patients with unexplained chronic cough. Furthermore, any adverse reactions will be thoroughly documented. If this hypothesized treatment is proven effective, this can greatly improve the care of chronic cough patients by allowing for an evidence-based treatment option and a treatment option that may improve access to care. While the superior laryngeal nerve (SLN) injection is typically performed by fellowship trained laryngologists, intramuscular injections could be more widely utilized by general otolaryngologists or providers in other fields of medicine.",[219,29,220],"Chronic Cough (CC)","Coughing",[222,223,224,225],"Throat","Chronic cough","Neurogenic cough","Unexplained cough","2025-07-09",{"date":228,"type":41},"2025-07-14",{"date":230,"type":41},"2024-12-02",{"date":232,"type":21},"2026-06-30",{"name":234,"class":101},"Medical University of South Carolina",{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":16,"minAge":242,"maxAge":4,"enrollmentInfo":243,"targetDuration":4,"studyType":60,"phases":245,"briefSummary":247,"conditions":248,"keywords":252,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":102},"100555062","phase-4-comparison-of-remimazolam-and-propofol-for-recovery-of-ambulatory-upper-airway-surgery-100555062","NCT06507202","Comparison of Remimazolam and Propofol for Recovery of Ambulatory Upper Airway Surgery","Comparison of Remimazolam Versus Propofol-based General Anesthesia on Postoperative Quality of Recovery in Patients Undergoing Ambulatory Upper Airway Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients (age 19 or older) undergoing ambulatory upper respiratory tract (nasal cavity, oral cavity, pharynx, larynx) surgery under general anesthesia\n* American Society of Anesthesiologists physical class classification I, II, and III\n\nExclusion Criteria:\n\n* Patients who refused to participate in the study\n* Pregnant patients\n* Patients with a history of hypersensitivity to drugs or additives used during surgery\n* Patients with acute narrow-angle glaucoma\n* Alcohol or drug dependent patients\n* Patients with Child-Pugh class C liver dysfunction","19 Years",{"count":244,"type":21},116,[246],"PHASE4","The purpose of this study is to compare the effects of remimazolam and propofol on postoperative recovery time, complications, and safety in patients undergoing ambulatory upper airway surgery under general anesthesia.",[29,249,250,251],"Pharyngeal Diseases","Oral Cavity Disease","Nasal Disease",[253,254,255],"remimazolam","upper airway surgery","ambulatory surgery","2024-07-11",{"date":258,"type":41},"2024-07-18",{"date":260,"type":41},"2024-01-22",{"date":262,"type":21},"2025-03-22",{"name":264,"class":101},"Chung-Ang University Gwangmyeong Hospital"]