[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"laryngeal-edema\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:laryngeal-edema":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100567617","phase-2-corticosteroids-for-post-extubation-dysphagia-100567617",false,"NCT06670521","Corticosteroids for Post-Extubation Dysphagia","Randomized Trial of Corticosteroids for Post-Extubation Aspiration","COPED","Inclusion Criteria:\n\n* Participant enrolled in primary study COMIRB #21-3873\u002F NCT # 05108896\n* Laryngeal edema identified on participants primary study Fiberoptic Endoscopic Evaluation of Swallowing (FEES) as defined as a revised Patterson edema score greater than zero\n* Admission to an ICU during their hospitalization\n* Mechanical ventilation with an endotracheal tube for greater than 48 hours.\n* Extubation except for compassionate extubation or transition to end-of-life care.\n\nExclusion Criteria:\n\n* Patient or provider refusal\n* Contraindication or corticosteroids defined as an allergic reaction (extremely rate) or taking other immunosuppressive medications.\n* Chronic treatment with corticosteroids (\\>= 40 mg Prednisone\u002Fday, \\>=32 Methylprednisolone\u002Fday)\n* Contraindication to enteral\u002Foral nutrition administration.\n* Pre-existing history of dysphagia or aspiration.\n* Pre-existing or acute primary central or peripheral neuromuscular disorder.\n* Presence of a chronic tracheostomy (present prior to ICU admission).\n* Pre-existing head and neck cancer or surgery.\n* Coagulopathy resulting in uncontrolled nasal or pharyngeal bleeding.\n* Delirium as assessed by CAM-ICU\n* Inability to obtain informed consent from patient or an appropriate surrogate.\n* Age \\\u003C18 years.","ALL","18 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","This is a placebo-controlled, double-blind randomized trial of a short course of intravenous corticosteroids for Acute Respiratory Failure Survivors with Fiberoptic Endoscopic Evaluation of Swallowing (FEES) documented laryngeal edema. Study was leveraged using the existing R01 grant infrastructure COMIRB # 21-3873, study design, and research methods. Patients for the study proposed will have already been enrolled in the R01 longitudinal cohort study. The sites to perform this study include Colorado, BU, Yale, Tufts, and Stanford. Those R01-enrolled patients with laryngeal edema on their initial FEES examination: defined as the revised Patterson edema score greater than zero, will be approached for enrollment.",[27,28],"Dysphagia","Laryngeal Edema","RECRUITING","2026-05-04",{"date":32,"type":33},"2026-05-06","ACTUAL",{"date":35,"type":33},"2024-12-02",{"date":37,"type":21},"2027-05-31",{"name":39,"class":40},"University of Colorado, Denver","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":49,"targetDuration":51,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":41},"100633218","laryngeal-edema-assessment-by-cuff-leak-test-and-ultrasound-in-icu-patients-and-its-relationship-with-weaning-success-100633218","NCT07523828","Laryngeal Edema Assessment by Cuff Leak Test and Ultrasound in ICU Patients and Its Relationship With Weaning Success","The Relationship Between Assessment of Laryngeal Edema in Intensive Care Patients Using Cuff Leak Test and Ultrasound-Guided Laryngeal Air Column Width Difference and Weaning Success","Inclusion Criteria:\n\n* Patients who have been intubated and receiving invasive mechanical ventilation for at least 24 hours in the Intensive Care Unit of Fatih Sultan Mehmet Training and Research Hospital and who are considered by the intensive care physician to be ready for weaning from mechanical ventilation:\n* Patients over 18 years of age\n* Patients who have given their voluntary consent\n\nExclusion Criteria:\n\n* Patients under 18 years of age\n* Patients with a history of oral cavity surgery such as direct laryngoscopy and biopsy, microlaryngoscopic surgery, tonsillectomy, adenoidectomy, soft palate, oropharynx, hypopharynx, larynx and trachea,\n* Patients with a history of allergy, asthma, reflux, upper respiratory tract viral or fungal infections, and cancer surgery,\n* Patients who received radiotherapy to the neck region, or who had more than one intubation attempt in the previous year,\n* Tracheostomized patients, patients with upper respiratory tract obstruction, vocal cord paralysis, and patients with stridor clinical picture before intubation,\n* Patients for whom voluntary consent cannot be obtained",{"count":50,"type":21},100,"1 Year","OBSERVATIONAL","This study evaluates laryngeal edema in ICU patients during weaning from mechanical ventilation. It compares the cuff leak test and ultrasound-based laryngeal air column measurements in predicting weaning success. Ultrasound offers a non-invasive and real-time alternative for airway assessment. The study also examines post-extubation complications such as stridor, sore throat, dysphonia, and dysphagia.",[28],[56,57,58,59],"laryngeal edema","airway ultrasound","cuff leak test","weaning success","NOT_YET_RECRUITING","2026-04-05",{"date":63,"type":33},"2026-04-13",{"date":65,"type":21},"2026-04-08",{"date":67,"type":21},"2026-08-30",{"name":69,"class":40},"Fatih Sultan Mehmet Training and Research Hospital"]