[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"larynx-carcinoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:larynx-carcinoma":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":24,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":5},"100538146","the-role-of-the-freepedunculated-flap-in-total-laryngectomy-after-chemo-radiotherapy-failure-for-laryngeal-carcinoma-impact-on-the-risk-of-pharyngocutaneous-fistula-pcf-100538146",false,"NCT06287034","The Role of the Free\u002FPedunculated Flap in Total Laryngectomy After (Chemo-)Radiotherapy Failure for Laryngeal Carcinoma: Impact on the Risk of Pharyngocutaneous Fistula (PCF)","Inclusion Criteria:\n\n* Histological confirmation of recurrence\u002Fpersistence of squamous cell carcinoma of the larynx previously subjected to exclusive radiotherapy or concomitant chemo-radiotherapy treatment:\n\n  1. pre (ChT-)RT staging: cT1\u002FT2\u002FT3 N0\u002FN+;\n  2. pre STL staging: rcT1\u002FcT2\u002F Selected cT3 cT4a (extension to thyroid cartilage and\u002For prelaryngeal tissues) N0\u002FN+ (clinically and radiologically).\n* Indication for STL surgery (no pharyngeal mucosal resection);\n* Functional total laryngectomies after radical (chemo-)radiotherapy treatment;\n* Age \\> 18 years;\n* Signature of informed consent and ability to complete in-office questionnaires.\n\nExclusion Criteria:\n\n* STL extended to the pharynx and\u002For total pharyngeal laryngectomies;\n* Extension of the tumor to the pharyngeal mucosa and\u002For massive extra-laryngeal extension;\n* Previous open organ preservation surgery (OPHL).","ALL","18 Years",{"count":18,"type":19},102,"ESTIMATED","OBSERVATIONAL","Multicenter, prospective, randomized study aimed at evaluating the difference in risk of PCF after salvage laryngectomy in two groups of patients: one cohort treated with Total Laryngectomy (LT) with primary suture, a second group treated with LT and reinforcement by flap positioning with onlay technique (PMM, ALT)",[23],"Larynx Carcinoma",[25],"pharyngocutaneous fistula","RECRUITING","2026-06-04",{"date":29,"type":30},"2026-06-05","ACTUAL",{"date":32,"type":30},"2023-03-21",{"date":34,"type":19},"2027-09-21",{"name":36,"class":37},"Regina Elena Cancer Institute","OTHER"]