[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"larynx\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:larynx":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,56,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100294151","accuracy-of-the-sensory-test-using-the-laryngopharyngeal-endoscopic-esthesiometer-in-obstructive-sleep-apnea-100294151",false,"NCT03109171","Accuracy of the Sensory Test Using the Laryngopharyngeal Endoscopic Esthesiometer in Obstructive Sleep Apnea","Accuracy of the Sensory Test Performed Using the Laryngopharyngeal Endoscopic Esthesiometer and Rangefinder in Patients With Suspected Obstructive Sleep Apnoea Hypopnea (OSA): a Prospective Double-blinded, Randomised, Pilot Study","Inclusion Criteria:\n\n* Patients being 18 years old or more referred to the sleep laboratory of a tertiary care university hospital for a baseline polysomnography for suspected OSA.\n\nExclusion Criteria:\n\n* Anticoagulation (though not a contraindication for the endoscopic laryngopharyngeal sensory test, anticoagulation is an exclusion criteria for this validation study in order to keep it a minimal-risk study).\n* Bleeding diathesis.\n* Basal awake oxygen saturation by pulse oximetry below 88%.\n* Not agree to participate in the study.\n* Glasgow coma scale below of 15 (to avoid confusion with involvement of laryngopharyngeal reflexes due to neurological disease accompanied by decreased level of consciousness).\n* Baseline polysomnography that does not meet validity criteria to be interpreted (according to the American Academy of Sleep Medicine).\n* Baseline polysomnography performed more than 15 days before the sensory testing. Ordinarily, the sensory testing will be performed the same day or the next day of baseline polysomnography.\n* More than 5% of total apnoea events being of central origin.\n* History of maxillofacial or pharyngeal surgery (to avoid confusion with involvement of laryngopharyngeal reflexes due to surgery in this region).\n* Laryngopharyngeal tract malignancies (to avoid confusion with involvement of laryngopharyngeal reflexes due to tumours).\n* Central Nervous System (CNS) surgery in the last three months or that has left neurological sequelae (to avoid confusion with involvement of laryngopharyngeal reflexes due to sequelae of CNS surgery).\n* Traumatic brain injury in the last three months or more than three month with neurological sequelae.\n* History of active neuromuscular disease that affects the muscles of head and neck or with sequels present at the time of the sensory testing (to avoid confusion with involvement of laryngopharyngeal reflexes due to neuromuscular disease).\n* History of cerebrovascular disease (to avoid confusion with dysphagia or sensory compromise secondary to cerebrovascular disease).\n* Diabetes (to avoid confusion with diabetic neuropathy that compromises the laryngopharyngeal region).\n* Chronic use of systemic corticosteroids at a dose greater or equal to 20 mg per day of prednisone or equivalent (to avoid confusion with steroid myopathy that compromises the laryngopharyngeal region).\n* Upper respiratory tract infection within 15 days prior to the testing (to avoid confusion with neuropathy associated with respiratory viral disease that compromises the laryngopharyngeal region).\n* Patient's inability to cooperate during the examination (to avoid measurement error caused by the lack of cooperation of the patient).",true,"ALL","18 Years",{"count":20,"type":21},117,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a prospective double blinded randomized crossover controlled trial aiming at validating the measurement of laryngopharyngeal mechanosensitivity in patients with suspected OSA using a recently developed laryngopharyngeal endoscopic esthesiometer and rangefinder (LPEER).\n\nSubjects will be recruited from patients with suspected OSA referred for baseline polysomnography to a university hospital sleep laboratory. Intra- and inter-rater reliability will be evaluated using the Bland-Altman's limits of agreement plot, the intraclass correlation coefficient, and the Pearson or Spearman correlation coefficient, depending on the distribution of the variables. Diagnostic accuracy will be evaluate plotting Receiver-operating-characteristic-curves (ROC-curves) using as reference standard basal polysomnogram. The sensory threshold values for patients with mild, moderate, and severe OSA, will be determined and compared using ANOVA or Kruskal Wallis test, depending on the distribution of the variables.",[27,28,29],"Sleep Apnea, Obstructive","Larynx","Sensory Disorder",[31,32,33,34,35,36,37,38,39,40,41,42],"Endoscopy","Lasers","Fiber Optic Technology","Bronchoscopy","Esthesiometer","Mechanoreceptors","Diagnosis","Reflex","Reproducibility of Results","Reliability of Results","Validity of Results","Sensory Thresholds","RECRUITING","2026-01-06",{"date":46,"type":47},"2026-01-08","ACTUAL",{"date":49,"type":47},"2018-01-01",{"date":51,"type":21},"2026-11-30",{"name":53,"class":54},"Fundación Neumologica Colombiana","OTHER",2,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":17,"minAge":63,"maxAge":18,"enrollmentInfo":64,"targetDuration":4,"studyType":22,"phases":66,"briefSummary":67,"conditions":68,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100552976","prevalence-of-eilo-among-children-with-asthma-100552976","NCT06480084","Prevalence of EILO Among Children With Asthma","The Prevalence of Exercise-Induced Laryngeal Obstruction (EILO) Amongst Children With Asthma' - a Prospective Cross-sectional Study","Inclusion Criteria:\n\n* Age 12 to 18 years\n* Paediatrician diagnosed asthma confirmed with at least one of the following during the last two years: Positive ECT (post-exercise fall in FEV1 \\> 10%) \u002F Positive methacholine test (PC20 value of ≤8 mg\u002FmL) \u002F Bronchodilator reversibility (increase in FEV1 ≥12% and\u002For ≥200 mL following inhalation of 200-400 μg short-acting β2-agonists)\n\nExclusion Criteria:\n\n* Other severe cardiopulmonary disease\n* Inability to perform ECT or CLE test\n* Inability to perform technically acceptable spirometry\n* Asthma exacerbation or respiratory tract infection in the last 2 weeks\n* Short-acting β2-agonists or long-acting β2-agonists use less than respectively 8 and 24 hours before the ECT or CLE test\n* Oral corticosteroid use in the 4 weeks before the ECT or CLE test","12 Years",{"count":65,"type":21},200,[24],"The goal of this cross-sectional study is to investigate the prevalence of Exercise Induced Laryngeal Obstruction (EILO) in children with asthma.\n\nThe hypothesis is that the prevalence will be around 15%, which is higher than the prevalence of 5-8% among the general adolescent population. This is based on the increased prevalence of EILO among adult asthmatics.\n\nParticipants who are referred for an Exercise Challenge Test will perform an additional Continuous Laryngoscopy during Exercise Test with expiratory FEV1 curves, and fill in the Borg scale for dyspnea, Asthma Control Test, EILODI questionnaire and DISCO-RC questionnaire.",[69,70,71,72,73,28],"Exercise Induced Laryngeal Obstruction","Asthma in Children","Exercise-Induced Bronchospasm","Exercise-Induced Bronchoconstriction","Dyspnea","NOT_YET_RECRUITING","2024-06-26",{"date":77,"type":47},"2024-06-28",{"date":79,"type":21},"2024-08-01",{"date":81,"type":21},"2026-04-30",{"name":83,"class":54},"Medisch Spectrum Twente",1,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":95,"conditions":96,"keywords":100,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":55},"100549840","voice-outcome-of-glottoplasty-cricothyroid-approximation-thyroplasty-and-chondrolaryngoplasty-100549840","NCT06439290","Voice Outcome of Glottoplasty, Cricothyroid Approximation, Thyroplasty, and Chondrolaryngoplasty","PURPOSE 1:\n\nInclusion criteria for surgery participants:\n\n* Persons who will soon undergo surgery on the vocal folds and\u002For larynx (including glottoplasty, cricothyroid approximation, thyroplasty and\u002For thyroid chondroplasty) at UZ Gent\n* At least 18 years old\n* Sufficient command of the Dutch language for understanding the informed consent letter and completing Dutch questionnaires\n\nInclusion criteria for volunteers to provide speech samples:\n\n\\- Cisgender men or women\n\nInclusion criteria for volunteer listeners for the listening experiment:\n\n* Dutch-speaking\n* Self-reported normal hearing\n\nPURPOSE 2: same as above.\n\nPURPOSE 3:\n\nInclusion criteria for the healthy participants:\n\n* At least 18 years old\n* Sufficient command of the Dutch language to complete a Dutch questionnaire\n\nExclusion criteria for the healthy participants:\n\n\\- One or more contraindications for an MRI examination. These contraindications are checked using a questionnaire (safety checklist).\n\nInclusion criteria for the pre- and postoperative MRI participants:\n\n\\- Random selection of +- 10 participants of purpose 1.\n\nExclusion criteria for the pre- and postoperative MRI participants:\n\n\\- One or more contraindications for an MRI examination. These contraindications are checked using a questionnaire (safety checklist).","70 Years",{"count":93,"type":21},290,[24],"The purpose of this study is to measure the short- and long-term voice outcome and outcome predictors of glottoplasty, cricothyroid approximation, thyroplasty, and chondrolaryngoplasty using a prospective non-randomized controlled trial and a multidimensional voice assessment protocol. Secondly, a laryngeal magnetic resonance imaging protocol will be developed to measure pre- and postoperative anatomical factors and compare them with the acoustic changes.",[97,28,98,99],"Surgery","Transgenderism","Gender Dysphoria",[101,102,103,104],"Transgender","Phonosurgery","Determinants","MRI","2024-05-30",{"date":107,"type":47},"2024-06-03",{"date":109,"type":47},"2024-04-10",{"date":111,"type":21},"2027-12",{"name":113,"class":54},"University Ghent"]