[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"laser-interstitial-thermal-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:laser-interstitial-thermal-therapy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100577563","possibilities-of-use-mri-guided-laser-interstitial-thermal-therapy-in-medically-intractable-tremor-100577563",false,"NCT06799923","Possibilities of Use MRI-Guided Laser Interstitial Thermal Therapy in Medically Intractable Tremor","Possibilities of Use Magnetic Resonance Imaging (MRI)-Guided Laser Interstitial Thermal Therapy (LITT) in Treatment of Medically Intractable Tremor","PossibiLITT","Inclusion Criteria:\n\n* Patients 18 years age or older with Parkinson\\'s disease or essential tremor and tremor resistant to medical therapy with a contraindication to deep brain stimulation or refusal deep brain stimulation\n\nExclusion Criteria:\n\n* Contraindication to MRI\n* Contraindication to general anesthesia\n* Patient unable to give their free and informed consent because of cognitive or psychiatric disorders\n* Brain anatomical abnormalities not allowing intervention\n* Adults protected (guardianship, curators) or deprived of liberty.","ALL","18 Years",{"count":20,"type":21},15,"ESTIMATED","INTERVENTIONAL",[24],"NA","Medically intractable tremors are a common difficult clinical situation. Deep brain stimulation decreases Parkinson's disease tremor and essential tremor, but not all patients are candidates from a diagnostic, medical, or social standpoint, prompting the need for alternative surgical strategies. Less invasive lesional brain surgery (thalamotomy) procedures by radio-surgery or MRI-guided focused ultrasound have emerged and have proven to be effective in these third-line indications. Recently, a new technology has emerged allowing the performance of minimally invasive lesion surgeries by MRI-Guided Laser Interstitial Thermal Therapy (MRIg-LITT). MRIg-LITT has been shown to be effective and safe in management of epilepsies and brain tumors. However, no study has evaluated MRIg-LITT for performing thalamotomy in medically intractable tremor.In a pilot study, the investigators propose to evaluate the effect and safety of unilateral thalamotomy by MRIg-LITT in the management of medically intractable tremor of parkinsonian or essential origin.",[27,28,29,30,31],"Laser Interstitial Thermal Therapy","Parkinson Disease","Essential Tremor","Movement Disorders","MRI",[33,28,29,30,31],"laser interstitial thermal therapy","RECRUITING","2025-01-28",{"date":37,"type":38},"2025-01-29","ACTUAL",{"date":40,"type":38},"2024-08-01",{"date":42,"type":21},"2026-04",{"name":44,"class":45},"Centre Hospitalier Universitaire, Amiens","OTHER"]