[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"laser-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:laser-therapy":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,75,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100643341","effectiveness-and-safety-of-a-hydrating-gel-containing-polyvinyl-pyrrolidine-algin-and-hyaluronic-acid-applied-after-and-without-fractional-co-laser-therapy-100643341",false,"NCT07639151","Effectiveness and Safety of a Hydrating Gel Containing Polyvinyl Pyrrolidine, Algin and Hyaluronic Acid Applied After and Without Fractional CO₂ Laser Therapy","Effectiveness and Safety of a Hydrating Gel Containing Aqua, Carrageenan, Polyvinyl Pyrrolidon, Algin, Gellan Gum, and Hyaluronic Acid Applied After and Without Fractional CO₂ Laser Therapy","Inclusion Criteria:\n\n1. Female participants aged 18-60 years.\n2. Patients attending the Dermatology and Venereology Outpatient Clinic of Universitas Indonesia Hospital (RSUI) who will receive the hydrating gel either following fractional CO₂ laser treatment or without undergoing the fractional CO₂ laser procedure.\n3. Patients who will undergo or have undergone a priming regimen with topical retinoic acid preparations at concentrations of at least 0.025%, 0.05%, or 0.1% for at least 2 weeks prior to fractional CO₂ laser treatment, or prior to study participation in the non-laser group.\n4. Willing to participate in the study and have provided written informed consent after receiving adequate explanation regarding the study.\n\nExclusion Criteria:\n\n1. Pregnant, breastfeeding, or currently using oral contraceptives at the time of assessment.\n2. History of systemic retinoid use within the past 3 months.\n3. History of or current treatment for hormonal\u002Fendocrine disorders or other serious medical conditions.\n4. Currently receiving immunosuppressive therapy.\n5. Participants who are unable or unwilling to comply with the study protocol and treatment regimen.",true,"FEMALE","18 Years","60 Years",{"count":21,"type":22},51,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this interventional study is to evaluate the effectiveness and safety of a hydrating gel containing aqua, carrageenan, polyvinyl pyrrolidone, algin, gellan gum, and hyaluronic acid. The study will assess the gel's ability to support optimal skin recovery following fractional CO₂ laser therapy and its effectiveness and safety as a daily adjunctive skincare treatment. Outcomes related to skin hydration, skin barrier function, tolerability, and adverse events will be evaluated throughout the study period.\n\nFemale participants aged 18 to 60 years who provide informed consent will be enrolled in this study. Participants will undergo a 2-week priming period with topical tretinoin prior to fractional CO₂ laser treatment. Clinical evaluations will be performed at baseline, immediately after the laser procedure, and on Days 3, 7, and 14 post-treatment. Assessments conducted by a board-certified dermatologist will include dermoscopy, TEWAmeter assessment, erythema assessment, and evaluation of pain and discomfort using a Visual Analog Scale (VAS).",[28,29,30,31],"Hydration","Carbon-dioxide Laser","Laser Therapy","Hydrogel",[31,33,28],"CO2 Fractional Laser","NOT_YET_RECRUITING","2026-06-05",{"date":37,"type":38},"2026-06-10","ACTUAL",{"date":40,"type":22},"2026-06",{"date":42,"type":22},"2026-09",{"name":44,"class":45},"Dr.dr.Irma Bernadette, SpKK (K)","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":46},"100623216","high-power-laser-versus-pulsed-electromagnetic-therapy-in-lumbar-radiculopathy-100623216","NCT07393750","High-power Laser Versus Pulsed Electromagnetic Therapy in Lumbar Radiculopathy.","High-Power Laser Versus Pulsed Eectromagnetic Therapy on Pain and Hoffman Reflex in Lumbar Radiculopathy.","Inclusion Criteria:\n\n* • Sixty lumbar radiculopathy patients, of both sexes, will represent the sample.\n\n  * The patient's age will range from 55 to 68 years old.\n  * Patients with degenerative lumbar disc lesion at L5-S1 confirmed by MRI and latency in H- reflex.\n  * Patients with unilateral sciatic radiating pain (from 5 to 8 by visual analogue scale).\n  * Patient with normal cognitive function (MME more than 25)\n  * BMI from 20-29.9\n\nExclusion Criteria:\n\n* The patients will be excluded if they have one of the followings:\n\n  1. Patients with pacemakers and presence of electronic implants.\n  2. Pregnant women.\n  3. History of or existing malignant conditions, active tuberculosis of the lungs.\n  4. Any medical condition that may cause sciatic nerve lesion except lumbar radiculopathy, (e.g., diabetes mellitus or collagen disorders).\n  5. Cardiac, renal or hepatic failures recent or previous history of seizures or epilepsy.\n  6. Previous surgery at L5-S1.\n  7. Bleeding disorders.\n  8. Serious infections of a viral, bacterial and fungal origin, conditions after organ transplants, upper motor neuron lesions.\n  9. Patients with cognitive impairment.","ALL","55 Years","68 Years",{"count":58,"type":22},60,[25],"To compare between high-power laser versus pulsed electromagnetic therapy on pain and Hoffman reflex in lumbar radiculopathy.",[62,63,64,30,65],"Lumbar Radiculopathy","Hoffman's Reflex","Pulsed Electromagnetic Therapy","Herniated Lumbar Disc","2026-01-31",{"date":68,"type":38},"2026-02-06",{"date":70,"type":22},"2026-03-29",{"date":72,"type":22},"2027-01",{"name":74,"class":45},"Cairo University",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":54,"minAge":18,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":46},"100594784","effect-of-phenol-addition-to-laser-treatment-on-epithelialization-and-healing-process-in-pilonidal-sinus-100594784","NCT07023952","Effect of Phenol Addition to Laser Treatment on Epithelialization and Healing Process in Pilonidal Sinus","Effect of Phenol Addition to Laser Treatment on Epithelialization and Healing Process in Pilonidal Sinus: A Prospective Randomized Controlled Clinical Trial","PLEPS","Inclusion Criteria:\n\n* Age 18 years and older\n* Primary pilonidal sinus disease\n* Three or fewer pit counts\n* Willing to participate in the study and signed informed consent form\n* Able to attend follow-up visits\n\nExclusion Criteria:\n\n* Age under 18 years\n* More than three pit counts\n* Acute abscess presentation\n* Bilateral lateral extension\n* Recurrent pilonidal sinus disease\n* Immunocompromised patients\n* Patients unable to attend follow-up visits\n* Pregnancy (if applicable)\n* Severe comorbidities that contraindicate surgery under local anesthesia",{"count":84,"type":22},130,[25],"This study compares two treatment approaches for pilonidal sinus disease: laser treatment alone versus laser treatment combined with phenol application. Pilonidal sinus is a common condition that affects young adults and can cause significant discomfort and time off work.\n\nParticipants will be randomly assigned to receive either laser treatment only (Group A) or laser treatment plus phenol application (Group B). Both treatments are minimally invasive and performed under local anesthesia as day surgery procedures.\n\nThe main goal is to determine if adding phenol to laser treatment speeds up the healing process (epithelialization) and improves patient outcomes. We will measure healing time, pain levels, return to daily activities, and quality of life over a 3-month follow-up period.\n\nThis research may help develop more effective treatment protocols that reduce healing time and improve patient comfort for people with pilonidal sinus disease.",[88,30],"Pilonidal Sinus Disease",[90,91],"Minimally Invasive Treatment","Day Surgery","RECRUITING","2025-06-14",{"date":95,"type":38},"2025-06-17",{"date":97,"type":38},"2025-05-01",{"date":99,"type":22},"2025-11-01",{"name":101,"class":45},"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":54,"minAge":18,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":46},"100569729","optimizing-vim-targeting-for-radiosurgery-in-severe-tremor-100569729","NCT06698029","Optimizing VIM Targeting for Radiosurgery in Severe Tremor","Optimisation du Ciblage du VIM Pour la Radiochirurgie Dans le Tremblement sévère","OptiRS","Inclusion Criteria:\n\n* Advanced, disabling, drug-resistant essential tremor\n* Patient selected as part of the multidisciplinary concertation meeting on abnormal movements\n* Patient aged 18 to 85\n* Brain MRI showing no anatomical abnormality contraindicating radiosurgical procedure\n* MATTIS ≥ 130\n* Subject affiliated to or benefiting from a social security scheme\n* Free, informed and written consent signed by the participant and the investigator (no later than the day of inclusion and before any examination required by the research).\n\nExclusion Criteria:\n\n* Patients with a contraindication to brain MRI (pacemaker, intracerebral metal object, etc.)\n* Pregnant or breast-feeding women","85 Years",{"count":112,"type":22},40,[25],"Essential tremor is a common neurological disease, the most severe form of which combines postural and intention tremor, with significant physical, psychological and social repercussions. It is in these most severe forms that surgical lesioning of the ventro-intermediate nucleus of the thalamus (VIM) has been proposed. The VIM and its region of interest are almost impossible to identify directly on imaging (especially MRI), as it is part of the thalamus, which has the same intensity. To identify it, teams use average coordinates from stereotactic atlases (imprecise due to the high inter-individual variability of brain anatomy) or retrospective series of implanted patients. The hypothesis of the present trial is that the VIM-RS-LAT-1.0 algorithm developed by RebrAIn for radiosurgery will enable targeting that is at least as effective as conventional targeting. This is a single-center, controlled study, the primary endpoint of which will be assessed at one year, in a blinded, phase 3, comparative, non-inferiority, randomized study in two parallel groups of patients with severe tremor undergoing radiosurgery. In the control group, VIM will be targeted conventionally, and in the experimental group, VIM will be targeted by the RebrAIn algorithm (VIM-RS-LAT-1.0 model) of radiosurgery.",[116,30],"Tremor","2024-11-18",{"date":119,"type":38},"2024-11-20",{"date":121,"type":22},"2025-01-01",{"date":123,"type":22},"2027-12-31",{"name":125,"class":45},"Assistance Publique Hopitaux De Marseille"]