[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"latent-autoimmune-diabetes-in-adult-lada\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:latent-autoimmune-diabetes-in-adult-lada":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100626324","evaluation-of-oxidative-stress-comparison-between-type-1-diabetes-mellitus-and-latent-autoimmune-diabetes-in-adults-100626324",false,"NCT07434154","Evaluation of Oxidative Stress: Comparison Between Type 1 Diabetes Mellitus and Latent Autoimmune Diabetes in Adults","Inclusion Criteria:\n\nPatients with with already known or newly diagnosed type 1 diabetes mellitus or LADA Patients aged ≥ 18 years and ≤ 75 years Patients of both sexes All patients will be selected among outpatients attending the Center of Diabetes and Metabolic Diseases of First Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation.\n\nExclusion Criteria:\n\nPatients refusing to sign informate consent.","ALL","18 Years","75 Years",{"count":19,"type":20},75,"ESTIMATED","OBSERVATIONAL","After obtaining informed consent, the investigators will recruit 75 patients with T1DM and 75 with LADA with an age ≥ 18 years and ≤ 75 years, of both sexes. All patients will be selected among outpatients attending the Center of Diabetes and Metabolic Diseases of First Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation. The study design will include one single visit where patients' medical history and blood samples will be collected. For incident cases, a follow-up visit at 3 months from the start of treatment will be scheduled to assess whether a decrease in HbA1c corresponds to a decrease in the biomarkers. For a comprehensive oxidative balance evaluation, the d-ROMs test will be carried out to evaluate the pro-oxidant status linked to one of the parameters related to the antioxidant potential (BAP test, OXY-Adsorbent test, -SHp test and anti-ROMs test). Parameters will be evaluated using Free Radical Elective Evaluator (FREE) Duo by Diacron International s.r.l. (Grosseto, ITALY), an integrated analytical system that permits any type of chemical-clinical analysis based on the principle of photometry. The investigators will also evaluate high sensitivity C-reactive protein (Hs-CRP), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA). To evaluate if there is an association between a worse stage of the diseases and some oxidative stress markers, the investigators will also evaluate glycated hemoglobin (HbA1c) fasting plasma glucose (FPG), post-prandial glucose (PPG). All plasmatic parameters will be determined after a 12-h overnight fast, with the exception of PPG, determined 2 hours after a standardized meal. Venous blood samples will be taken for all patients between 8 A.M. and 9 A.M. The investigators will use plasma obtained by addition of Na2-ethylenediaminetetraacetic acid (EDTA), 1 mg\u002Fml, and centrifuged at 3000 g for 15 minutes at 4°C. Immediately after centrifugation, the plasma samples will be frozen and stored at -80 °C for no more than 3 months. All measurements will be analyzed by the Laboratory of Molecular Medicine, General Medicine 1, IRCCS Policlinico San Matteo Foundation with proven experience in the dosage of these markers.",[24,25],"Type 1 Diabetes Mellitus","Latent Autoimmune Diabetes in Adult (LADA)",[27,28,29],"Type 1 diabetes mellitus","Latent Autoimmune Diabetes in Adult","Oxidative stress","RECRUITING","2026-03-28",{"date":33,"type":34},"2026-04-02","ACTUAL",{"date":36,"type":34},"2025-10-01",{"date":38,"type":20},"2026-08-31",{"name":40,"class":41},"Fondazione IRCCS Policlinico San Matteo di Pavia","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":50,"targetDuration":52,"studyType":21,"phases":4,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100629537","prevalence-and-risk-factors-of-metabolic-associated-hepatic-steatosis-in-individuals-living-with-type-1-diabetes-100629537","NCT07475962","Prevalence and Risk Factors of Metabolic-Associated Hepatic Steatosis in Individuals Living With Type 1 Diabetes","STEA-DT1","Inclusion Criteria:\n\n* Individuals ≥ 18 years of age.\n* A clinical diagnosis of type 1 diabetes or Latent Autoimmune Diabetes in Adults (LADA) for at least one year, as per the investigators' clinical judgment (confirmatory C-peptide and antibodies will not be required).\n\nExclusion Criteria:\n\n* Alcohol consumption exceeding 20g per day in women or 30g per day in men.\n* Known chronic liver disease (including viral, drug-induced, Wilson disease, deficit in alpha-1-antirypsin, hemochromatosis, autoimmune hepatitis, etc.).\n* Evidence of cirrhosis based on a result of liver biopsy, or history of portal hypertension presented by ascites, hepatic encephalopathy or varices.\n* History of use of medications known to induce liver steatosis, including corticosteroids, high-dose estrogens, tamoxifen, methotrexate, amiodarone, or tetracycline.\n* Ongoing pregnancy.\n* Life expectancy of less than 5 years, as per investigators' clinical judgment.",{"count":51,"type":20},100,"3 Days","The goal of this observational cross-sectional study is to assess the prevalence and stage of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), specifically liver steatosis and fibrosis in adults aged 18 and older living with type 1 diabetes or Latent Autoimmune Diabetes in Adults (LADA) in Quebec.\n\nThe main questions it aims to answer are:\n\n1. What is the prevalence and severity of liver steatosis and fibrosis among people living with type 1 diabetes in Québec?\n2. Are there patients with type 1 diabetes who have advanced, undiagnosed stages of liver disease that require management but are missed by current standard care practices?\n\nResearchers will compare three participant subgroups based on adiposity (a control group without increased adiposity, an overweight group with increased adiposity, and an obesity group with increased adiposity) to see if the prevalence and severity of hepatic steatosis and fibrosis are highest in the obesity group and lowest in the control group. They will also explore if variables and potential risk factors associated with liver disease differ across these subgroups.\n\nParticipants will attend a single study visit where they will be asked to:\n\n* Provide clinical data through laboratory analyses.\n* Undergo specific clinical procedures.\n* Complete validated questionnaires.",[55,56,57,58,25],"Type 1 Diabetes","Liver Steatoses","MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease","Liver Fibrosis",[60,61,62,63,64,65],"MASLD","Liver steatosis","Liver fibrosis","LADA","Body composition","Type 1 diabetes","NOT_YET_RECRUITING","2026-03-19",{"date":69,"type":34},"2026-03-23",{"date":71,"type":20},"2026-04-01",{"date":73,"type":20},"2027-05-30",{"name":75,"class":41},"Institut de Recherches Cliniques de Montreal",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":15,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":42},"100590460","building-and-sustaining-exercise-habits-for-adults-with-type-1-diabetes-100590460","NCT06967701","Building and Sustaining Exercise Habits for Adults With Type 1 Diabetes","Informatics-Based Digital Intervention to Promote Safe Exercise in Middle-Aged Adults With Type 1 Diabetes and Other Absolute Insulin Deficiency Diabetes - A Pilot Efficacy Study","Inclusion criteria:\n\n* 30-65 years old inclusive\n* Diagnosis with type 1 diabetes (T1D) or other insulin deficiency diabetes (latent autoimmune disease of adulthood, diabetes secondary to pancreatitis)\n* Less than 1.0 exercise sessions per week\n* Smartphone ownership\n* English literacy\n* Under regular care by a healthcare provider (1+ appointments per year)\n* Home Broadband wireless Internet or cell phone network\n* Using continuous glucose monitor (CGM) and sharing data with medical record for at least 6 weeks\n* Using insulin pump or pen and sharing data with medical record for at least 6 weeks\n\nExclusion criteria:\n\n* Diabetic ketoacidosis not clearly related to pump site failure in past 6 months\n* \\>1 episode of severe hypoglycemia (altered mental and\u002For physical status requiring assistance from another person for recovery) in past 6 months\n* A1c ≥10.0%\n* Resting blood pressure \\>160mmHg systolic or \\>100 mmHg diastolic.\n* Myocardial infarction or angina in past 12 months\n* Uncontrolled arrhythmia (e.g., atrial fibrillation with rapid ventricular response, new onset atrial fibrillation, ventricular tachycardia, escape rhythms)\n* Congestive heart failure (stage 3 or 4)\n* Exercise-induced asthma (not controlled on inhalers)\n* Chronic obstructive pulmonary disease (requiring home oxygen)\n* Renal failure\n* Pregnancy\n* Cognitive impairment\n* Severe retinopathy or neuropathy.\n* Other chronic disease or physical disability that would influence exercise intervention (e.g., recent spinal surgery)","30 Years","65 Years",{"count":86,"type":20},60,"INTERVENTIONAL",[89],"NA","The challenges of living with type 1 diabetes often stand in the way of getting enough exercise. Continuous blood sugar monitoring has revolutionized type 1 diabetes care but remains underutilized to sustainably support exercise and related behaviors. This remote participation-based research will develop a mobile application that delivers personalized encouragement and data-driven health insights based upon patterns in blood sugar, exercise, mood, and sleep, to assist people with type 1 diabetes in exercising more frequently and confidently. You do not need to live in Connecticut to participate, as there will be no required in-person visits during the study.",[92,25,93],"Type 1 Diabetes (T1D)","Pancreatitis",[95,96,97,98,99],"exercise","physical activity","mobile phone","health coaching","fitness watch","2025-11-04",{"date":102,"type":34},"2025-11-06",{"date":104,"type":34},"2025-07-10",{"date":106,"type":20},"2027-07",{"name":108,"class":41},"Yale University"]