[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ldl-c\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ldl-c":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100629762","impact-of-the-corrie-lipids-digital-health-program-on-lipid-optimization-100629762",false,"NCT07478887","Impact of the Corrie Lipids Digital Health Program on Lipid Optimization","Corrie Lipids Program: Optimizing LDL-Cholesterol by Improving Awareness, Access, and Achievement","Inclusion Criteria:\n\n* Age ≥18 years\n* Uncontrolled LDL-C per AHA\u002FACC guidelines\n* At least 1 major cardiovascular risk factor, including: high risk for ASCVD (individuals who meet criteria for Lipid-Lowering Therapy (LLT) based on ASCVD risk assessment using the most up-to-date guidelines), known ASCVD or subclinical ASCVD based on imaging, clinically diagnosed familial hypercholesterolemia or LDL-C ≥190 mg\u002FdL, diabetes mellitus, history of statin-associated side effects\n* Has a primary care physician and\u002For cardiologist who can prescribe lipid therapy\n* Owns a smartphone and agrees to the End User License Agreement to use the digital health app\n* Provided informed consent before initiation of study-specific activities\n\nExclusion Criteria:\n\n* Motor, cognitive, auditory, or visual impairment limiting technology use\n* Does not speak English\n* Malignancy (except nonmelanoma skin cancers or cervical or breast ductal carcinoma in situ within the previous 5 years)\n* Pregnancy (positive pregnancy test, highly sensitive urine or serum), plan to become pregnant or donate eggs, breastfeeding or plan to breastfeed\n* Likely to not be available to comply with all required study procedures to the best of the patient's and investigator's knowledge\n* History or evidence of any other clinically significant disorder, condition, or disease that, in the opinion of the investigator, would pose a risk to patient safety or interfere with the study evaluation, procedures, or completion","ALL","18 Years",{"count":19,"type":20},1000,"ESTIMATED","INTERVENTIONAL",[23],"NA","The overall objective is to evaluate the effectiveness and implementation of the Corrie Lipids Program, a comprehensive digital health initiative designed to address critical gaps in lipid-lowering as a component of ASCVD treatment by delivering an intervention that combines a patient-facing smartphone app, clinician education and coaching, and seamless incorporation into clinical workflows.\n\nResearchers plan to assess this multicenter digital health initiative in approximately 1,000 adults with uncontrolled LDL-C and elevated ASCVD risk using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. The study will examine whether the program improves LDL-C goal attainment, app engagement, prescribing patterns, and LDL-C monitoring, while also identifying barriers and facilitators to implementation across sites.",[26,27,28,29,30],"Cardiovascular Risk","LDL-C","Lipids","Digital Health","Implementation Science",[32,33],"Apolipoprotein B (apoB)","Lipoprotein-a (Lp(a)","RECRUITING","2026-03-13",{"date":37,"type":38},"2026-03-18","ACTUAL",{"date":40,"type":38},"2025-06-20",{"date":42,"type":20},"2027-12",{"name":44,"class":45},"Johns Hopkins University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":46},"100552280","test-2-treat-can-we-improve-the-testing-and-treatment-of-high-cholesterol-in-patients-who-have-been-hospitalized-for-a-cardiac-event-by-providing-education-to-doctors-and-patients-100552280","NCT06471036","Test 2 Treat: Can we Improve the Testing and Treatment of High Cholesterol in Patients Who Have Been Hospitalized for a Cardiac Event by Providing Education to Doctors and Patients?","Test 2 Treat: A Randomized Implementation Trial to Improve LDL-C Management After Hospitalization for ASCVD (Atherosclerotic Cardiovascular Disease)","T2T","Inclusion Criteria:\n\n1. Age ≥ 18 years old\n2. Admitted with Type 1 NSTEMI or STEMI, and\u002For percutaneous coronary revascularization\n3. LDL-C level during admission ≥ 70 mg\u002FdL\n4. Primary care clinician and\u002For cardiologist within the health system (and with access to the same EHR) who will manage the patient in the outpatient setting\n\nExclusion Criteria:\n\n1. Determined to be highly unlikely to survive and\u002For to continue follow-up in that health system for at least 6 months (including those on hospice or with significant dementia), as identified by site investigator\n2. Underwent CABG (would therefore be discharged from surgical service)",true,{"count":57,"type":20},400,[23],"The goal of this implementation trial is to learn if providing education to doctors and patients who have had a heart event works to prevent future heart problems. The main questions it aims to answer are:\n\n1. Does educating the doctors in a health system improve how often patients in the hospital for a heart event have their cholesterol checked?\n2. Can a \"care champion\" who calls patients who have been discharged from the hospital after a heart event help patients to achieve their cholesterol goals?\n\nResearchers will compare the number of people who achieve their cholesterol goals with the help of the care champion to the number of people who did so without the intervention to see if the care champion works to help patients lower their cholesterol.\n\nParticipants will:\n\nComplete two 15 minute surveys over the phone - 1 at enrollment and 1 at the end of the study 6 months later.",[61,27],"ASCVD",[30,63,64,65,66],"atherosclerotic cardiovascular disease (ASCVD)","low-density lipoprotein cholesterol (LDL-C)","Intervention","care champion","2025-07-22",{"date":69,"type":38},"2025-07-25",{"date":71,"type":38},"2024-10-08",{"date":73,"type":20},"2027-02-28",{"name":75,"class":45},"Duke University"]