[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"left-atrial-appendage-thrombosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:left-atrial-appendage-thrombosis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,65,95],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100642910","exclusion-of-left-atrial-appendage-thrombus-in-emergency-department-patients-with-atrial-fibrillation-undergoing-ct-to-assess-for-pulmonary-embolus-a-feasibility-study-100642910",false,"NCT07647939","Exclusion of Left Atrial Appendage Thrombus in Emergency Department Patients With Atrial Fibrillation Undergoing CT to Assess for Pulmonary Embolus: A Feasibility Study","ELATE-AF","Inclusion Criteria:\n\n* Patients above 18 years of age years deemed candidates for CT angiography for pulmonary embolism by the primary team on clinical grounds and noted to be in atrial fibrillation at the time.\n* Room air oxygen saturation above 92%\n* Systolic blood pressure above 100 mm Hg\n* Respiratory rate less than 24 breaths\u002Fmin\n\nExclusion Criteria:\n\n* Inability to personally give informed consent\n* Pregnant or breastfeeding individuals\n* Stroke like symptoms\n* ECG criteria for ischemia or infarction\n* Heart rate \\\u003C40 or \\> 120 bpm (inclusive) or 3rd degree heart block\n* Unable to lie flat for at least 10 minutes\n* Unable to follow simple commands\n* Northwell Health Employees.\n* Non-English-speaking patients","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to investigate whether a quick, additional CT scan of the heart, performed immediately after a standard CT scan for pulmonary embolism, can effectively detect blood clots in the left atrial appendage (LAA) in patients with atrial fibrillation. Detecting these clots is crucial before certain heart procedures to prevent stroke. Currently, a different, more involved procedure (Transesophageal Echocardiography - TEE) is often used. This study will assess if this additional CT scan is feasible, meaning if it can provide clear enough images to identify LAA clots without needing more contrast dye. The study will involve 60 patients, half receiving an \"ungated\" CT scan and the other half a \"gated\" CT scan (timed with their heart rhythm). The results of these scans will not be used for immediate patient care during the study, but rather to evaluate the CT scan technique itself. There is no direct benefit to participants, but the information gained could lead to faster diagnosis and reduced unnecessary testing for future patients.",[26,27,28],"Atrial Fibrillation (AF)","Pulmonary Embolism (PE)","Left Atrial Appendage Thrombosis","NOT_YET_RECRUITING","2026-06-09",{"date":32,"type":33},"2026-06-15","ACTUAL",{"date":35,"type":20},"2026-07",{"date":37,"type":20},"2027-06",{"name":39,"class":40},"Northwell Health","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":41},"100516695","intracardiac-echocardiography-guided-watchman-device-implant-100516695","NCT06007872","Intracardiac Echocardiography Guided Watchman Device Implant","Feasibility: Intracardiac Echocardiography Guided Watchman Device Implant","Inclusion Criteria:\n\n* All patients who meet guideline established criteria for commercially available Watchman device implant and not enrolled in an active clinical trial\n\nExclusion Criteria:\n\n* Patients in whom a procedural TEE cannot be performed and an ICE only implant is needed.\n* Patients receiving a concomitant ablation procedure\n* Patients with prior incomplete surgical or percutaneous left atrial appendage ligation\u002Fexclusion procedures\n* Patients in whom the delivery of trans-septal equipment is anticipated to be difficult (e.g. patent foramen ovale (PFO) or atrial septal defect (ASD) closure devices in place).",{"count":50,"type":20},100,[23],"This study is to look at the success of Intracardiac Echocardiography (ICE) in the Watchman procedure. Currently the process is to use a Transesophageal Echocardiography (TEE) to place the Watchman in patients. This study is aiming to show how the ICE is just as effective in placing the device correctly and effectively.",[54,28],"Atrial Fibrillation","RECRUITING","2025-10-17",{"date":58,"type":33},"2025-10-21",{"date":60,"type":33},"2022-12-02",{"date":62,"type":20},"2027-12-31",{"name":64,"class":40},"The Cleveland Clinic",{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":75,"phases":4,"briefSummary":76,"conditions":77,"keywords":82,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":41},"100561059","detecting-cardiac-thrombi-in-acute-ischemic-stroke-on-cardiac-ct-versus-transoesophageal-echocardiography-100561059","NCT06585228","Detecting Cardiac Thrombi in Acute Ischemic Stroke on Cardiac CT Versus Transoesophageal Echocardiography","Detecting Cardiac Thrombi in Acute Ischemic Stroke on Cardiac CT Versus Transoesophageal Echocardiography (MtH-DETECT)","MtH-DETECT","Inclusion Criteria:\n\n* Age 18 years or older\n* Clinical diagnosis of acute ischemic stroke\n* Written informed consent from patient or representative\n* Radiological diagnosis of cardiac thrombus in the LA, including the LAA, on cardiac CT acquired during the initial stroke imaging protocol.\n\nExclusion Criteria:\n\n* Patients with a diagnosis other than acute ischemic stroke, such as: transient ischemic attack, intracerebral haemorrhage, subarachnoid haemorrhage, epilepsy, tumor.\n* Absolute contraindication for TEE:\n\n  * Perforated viscus\n  * Esophageal stricture\n  * Esophageal tumor\n  * Esophageal perforation, laceration\n  * Esophageal diverticulum\n  * Active upper GI bleed\n* Absolute contraindication for repeat cardiac CT\n\n  * Documented previous severe reaction to iodinated contrast media, including anaphylaxis, angioedema and bronchospasm.\n  * Severely impaired kidney function defined as estimated glomerular filtration rate of 30 mL\u002Fmin\u002F1.73 m2.",{"count":74,"type":20},39,"OBSERVATIONAL","Rationale:\n\nCardiac CT acquired during the acute stroke imaging protocol (acute cardiac CT) has recently been shown to have a superior diagnostic yield than transthoracic echocardiography, which is currently the most commonly used method to screen for structural sources of cardioembolism in patients with acute ischemic stroke. The most common finding on acute cardiac CT are cardiac thrombi located in the left atrium (LA) and specifically the left atrial appendage (LAA). The higher diagnostic yield of acute cardiac CT compared to TTE is partially explained because CT allows for better visualization of the LAA, but also because cardiac thrombi may dissolve in the first days after stroke. Whether acute cardiac CT is the optimal diagnostic modality for LA thrombi in stroke patients is unknown, since data comparing it to transoesophageal echocardiography (TEE), which is the reference standard to detect LA thrombi, are lacking. The general hypothesis of this study is that acute cardiac CT is the optimal method to detect LA thrombi in ischemic stroke patients, since TEE can miss LA thrombi that dissolve in the first days after stroke.\n\nObjectives:\n\n1. Determine whether acute cardiac CT has a higher diagnostic probability of detecting LA thrombi compared to TEE or repeated cardiac CT in the subacute phase of ischemic stroke by assessing the rate at which LA thrombi dissolve in the first days after ischemic stroke occurrence.\n2. Determine the positive predictive value of acute cardiac CT compared to TEE for the detection of LA thrombi. Study design: Prospective, single-centre, observational cohort Study population: 39 patients of 18 years or older with acute ischemic stroke and a LA thrombus detected on cardiac CT acquired during the acute stroke imaging.\n\nMain study parameters\u002Fendpoints:\n\n1. Rate at which LA thrombi visualized on acute cardiac CT dissolve in the first days after ischemic stroke.\n2. False-positive rate for detection of left atrial thrombi on acute cardiac CT compared to TEE. Nature and extent of the burden and risks associated with participation, benefit and group relatedness: Clinical and imaging patient data which are obtained as part of standard care will be prospectively collected after written informed consent. Patient with a LA thrombus on acute cardiac CT will undergo TEE for research purposes after obtaining written informed consent. TEE is semi-invasive and associated with a small risk of major complications (\\\u003C0.2%). Patients will also be exposed to additional radiation (1.4 mSV) due to sequential cardiac CT after TEE. The Radiation Dose Committee deemed this to be an intermediate risk. In a small minority of patients (\\\u003C10%), another cardiac CT will be acquired 2 minutes after this sequential cardiac CT to ensure a clear, final assessment of the presence of an atrial appendage thrombus. This will result in a total additional radiation of 3 mSV for the two additional cardiac CT's. The Radiation Dose Committee deemed this to be an intermediate risk. As part of standard care, patients will be contacted for follow-up evaluation by a trained stroke nurse at 90 days. As a result of ischemic stroke, some patients become incapacitated to an extent they are unable to give informed consent. In these cases, the legal representative will be asked for informed consent. Decreased leveI of consciousness or aphasia are typical clinical characteristics of cardioembolic stroke. Therefore, it is pivotal to also include incapacitated acute ischemic stroke patients. Excluding these patients from the study would render the study non-representative of the study's target population (acute ischemic stroke patients with cardioembolic stroke due to LA thrombus).",[78,79,80,81,28],"Ischemic Stroke","Cardioembolic Stroke","Thrombus; Embolism","Left Atrial Thrombosis",[83,84,85],"Cardiac CT","Transoesophageal echocardiography","Ischemic stroke","2025-01-30",{"date":88,"type":33},"2025-02-03",{"date":90,"type":33},"2024-08-19",{"date":92,"type":20},"2026-10-01",{"name":94,"class":40},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":21,"phases":103,"briefSummary":104,"conditions":105,"keywords":106,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":4},"100529358","the-left-atrial-appendage-closure-by-surgery-and-the-incidence-of-stroke-in-patients-undergoing-open-heart-surgery-100529358","NCT06172738","The Left Atrial Appendage Closure by Surgery and the Incidence of Stroke in Patients Undergoing Open-heart Surgery.","The Left Atrial Appendage Closure by Surgery and the Incidence of Stroke in Patients Undergoing Open-heart Surgery Irrespective of Preoperative Atrial Fibrillation Status and Stroke Risk.","Inclusion Criteria:\n\n* ≥18 years scheduled for first-time planned open-heart surgery.\n\nExclusion Criteria:\n\nPediatric population \\>18 years. Emergent open heart surgery. Patients with current endocarditis. Where follow-up is not possible. The patient refused to sign the informed consent to participate in the research.",{"count":50,"type":20},[23],"This study aims to assess the efficacy and safety of prophylactic surgical closure of the left atrial appendage for stroke and cardiovascular death prevention in patients undergoing open heart surgery, regardless of their preoperative AF status and stroke risk.",[28],[107,108,109],"surgical closure of the left atrial appendage.","stroke","Post operative atrial fibrillation.","2023-12-07",{"date":112,"type":33},"2023-12-15",{"date":114,"type":20},"2024-01-01",{"date":116,"type":20},"2027-12-30",{"name":118,"class":40},"Assiut University"]