[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"leg-pain-andor-back-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:leg-pain-andor-back-pain":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100637903","sciatic-neural-mobilization-in-lumbar-related-leg-pain-100637903",false,"NCT07588919","Sciatic Neural Mobilization in Lumbar-Related Leg Pain","Immediate Effects of Sciatic Neural Mobilization on Balance and Proprioception in Patients With Low Back Pain and Radiating Leg Pain: A Prospective Randomized Clinical Trial","Inclusion Criteria:\n\n* Having low back pain accompanied by radiating leg pain (radicular or pseudoradicular pain) for at least 3 weeks\n* Demonstration of peripheral nerve sensitivity through clinical evaluation and neurodynamic tests\n* Pain intensity of at least 3 on the Visual Analog Scale (VAS)\n* Ability to understand verbal and written Turkish instructions\n* Providing signed informed consent\n\nExclusion Criteria:\n\n* Presence of surgical indication due to acute disc herniation or advanced lumbar disc pathology\n* History of spinal surgery or spinal trauma\n* Low back pain associated with other pathologies (e.g., rheumatic diseases, multiple sclerosis, malignancy)\n* Instability conditions such as spondylolysis and spondylolisthesis\n* Pregnancy\n* Obesity (BMI ≥ 30 kg\u002Fm²)\n* Orthopedic problems or chronic diseases that may limit exercise participation\n* Physiotherapy or steroid injection treatment within the last 3 months","ALL","18 Years","50 Years",{"count":20,"type":21},52,"ESTIMATED","INTERVENTIONAL",[24],"NA","Low back pain is one of the most prevalent musculoskeletal disorders worldwide and significantly reduces individuals' quality of life, functional capacity, and productivity. Lumbar-related leg pain (LRLP) is observed in a substantial proportion of patients with low back pain and is associated with neurodynamic dysfunctions arising from peripheral nerve sensitization. Although the effects of neural mobilization on pain and functional outcomes have been investigated in the literature, studies examining its short-term effects on balance and proprioception remain limited. Therefore, this study aims to determine the immediate effects of sciatic nerve neural mobilization on balance and proprioception in individuals with LRLP exhibiting peripheral nerve sensitivity.\n\nThe study will be designed as a prospective, randomized, controlled clinical trial. Participants will be recruited from individuals presenting to the Istinye University Health Practice and Research Center Hospital who meet the inclusion criteria. Following random allocation, 52 participants will be assigned either to the intervention group (neural mobilization) or the sham group (sham mobilization). In addition to a single-session standard conventional physiotherapy program, each group will receive its respective intervention protocol. Assessments will be conducted at two time points: before treatment and immediately after treatment.\n\nStatic and dynamic balance as well as proprioception will be evaluated using the ProKin balance system; muscle mechanical properties will be assessed using the MyotonPRO device; pain threshold will be measured with an algometer; and flexibility will be evaluated using the sit-and-reach test.",[27,28],"Low Back Pain","Leg Pain and\u002For Back Pain","NOT_YET_RECRUITING","2026-05-09",{"date":32,"type":33},"2026-05-15","ACTUAL",{"date":35,"type":21},"2026-06-15",{"date":37,"type":21},"2026-10-15",{"name":39,"class":40},"Istinye University","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":68},"100442175","magnetos-flex-matrix-compared-to-trinity-elite-mixed-with-local-autograft-in-patients-undergoing-up-to-four-level-instrumented-posterolateral-fusion-100442175","NCT05037968","MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion","A Prospective, Randomized, Multi-center Study to Assess the Performance of MagnEtOs Flex Matrix Mixed With Local Autograft Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented poSterolatEral Lumbar\u002FThoraco-lumbar Fusion (PLF)","PRECISE","Inclusion Criteria:\n\n* Patient is able to read\u002Fbe read, understand, and provide written informed consent and has signed the Investigational Review Board (IRB) approved informed consent.\n* Male or female patient ≥ 18 years old.\n* Patients with leg pain, and\u002For back pain requiring up to four-level instrumented posterolateral lumbar\u002Fthoraco-lumbar fusion (T11 - S1)\n* Failed conservative treatment (physical therapy, bed rest, medications, spinal injections, manipulations, or transcutaneous electrical nerve stimulation) for a minimum period of 3 months prior to study enrollment.\n\nExclusion Criteria:\n\n* Requires \\> four-level fusion or expected to need secondary intervention within one year following surgery.\n* Had prior PLF fusion or attempted PLF fusion at the involved levels\n* Had previous decompression at the involved levels.\n* Women who are or intend to become pregnant within the next 12 months\n* To treat conditions in which general bone grafting is not advisable.\n* In conditions where the surgical site may be subjected to excessive impact or stresses, including those beyond the load strength of fixation hardware (e.g., defect site stabilization is not possible).\n* In case of significant vascular impairment proximal to the graft site.\n* In case of severe metabolic or systemic bone disorders (e.g., osteogenesis imperfecta or Paget's Disease) that affect bone or wound healing.\n* In case of acute and chronic infections in the operated area (soft tissue infections; inflammation, bacterial bone diseases; osteomyelitis).\n* When intraoperative soft tissue coverage is not planned or possible.\n* Receiving treatment with medication interfering with calcium metabolism.\n* Had leg pain, and\u002For back pain related to a benign or malignant tumor.\n* Had history or presence of active malignancy.\n* Has known substance abuse, psychiatric disorder, or condition which, in the opinion of the investigator, may influence the healing or ability to comply with protocol requirements.\n* Is involved in active litigation relating to his\u002Fher spinal condition.\n* Has participated in an investigational study within 30 days prior to surgery for study devices.",{"count":50,"type":21},100,[24],"This is a phase IV post-marketing study for MagnetOs Flex Matrix. MagnetOs Flex Matrix is a synthetic bone graft extender product that is routinely used by surgeons as a treatment for patients with degenerative disc disease and undergoing spinal fusion surgery.\n\nIn this study, MagnetOs Flex Matrix will be used according to the latest U.S. Instructions For Use, specifically as a bone graft extender mixed with autograft in a 1:1 vol.% in the posterolateral spine.\n\nTrinity Elite will also be used according to its latest IFU approved in the US. Specifically, this cellular based allograft is an allograft intended for the treatment of musculoskeletal defects.",[54,55,28],"Degenerative Disc Disease","Spine Fusion",[54,55],"RECRUITING","2026-02-23",{"date":60,"type":33},"2026-02-25",{"date":62,"type":33},"2024-06-10",{"date":64,"type":21},"2026-12",{"name":66,"class":67},"Kuros Biosurgery AG","INDUSTRY",7]