[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"length-of-stay\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:length-of-stay":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,52,85,116,150,171,208,237,266,316],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100609439","nicu-utilization-of-remote-voice-technology-to-improve-maternal-experience-nurture-100609439",false,"NCT07214597","NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)","NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE): A Randomized Controlled Trial","NURTURE","Inclusion Criteria:\n\n1. Infant:\n\n   1. Admitted to the neonatal intensive care unit (NICU)\n   2. Not readmitted after discharge from the NICU\n   3. Expected to survive at least 2 weeks\n   4. Expected to be admitted to the NICU for at least 2 weeks\n   5. Singleton gestation\n2. Mother:\n\n   1. Age ≥ 18 years old\n   2. English speaking\n   3. Mother is the biological mother of the infant admitted to the NICU\n   4. Postpartum day 4 or less\n3. Partner (NOTE: Partner enrollment is not required)\n\n   1. Mother agrees to partner's participation\n   2. Designated by mother as support person with infant access\n\nExclusion Criteria\n\n1. Infant\n\n   a. Re-admission to NICU\n2. Mother\n\n   1. No access to an Android or iOS smartphone\n   2. Unwilling to download the VoiceLove NICU app to their personal smartphone and unwilling to accept the terms and conditions of the VoiceLove app\n   3. No personal email address\n   4. Incarcerated at time of delivery or postpartum\n   5. Inability to obtain informed consent\n\n   i. Patient's clinician refuses enrollment of the patient ii. Patient is either mentally (acute psychosis) or physically (intubated or critically ill in the ICU) unable to provide informed consent f. Unable to approach the patient (staffing, patient unavailable) g. Mother is not the intended parent (plans adoption, is a surrogate, will not have custody of the infant)\n3. Partner (NOTE: Partner enrollment is not required)\n\n   1. Age \\\u003C 18 years old\n   2. Not English speaking\n   3. Inability to obtain informed consent\n   4. No access to an Android or iOS smartphone that is different from the mother's smartphone\n   5. No access to an email address that is different from the mother's email address\n   6. Unwilling to download the VoiceLove NICU app to their personal smartphone and unwilling to accept the terms and conditions of the VoiceLove app",true,"FEMALE","18 Years",{"count":21,"type":22},150,"ESTIMATED","INTERVENTIONAL",[25],"NA","The study's objective is to conduct a Phase II randomized controlled trial examining the preliminary efficacy of the VoiceLove app compared to usual care on maternal postpartum depression in mothers with infants admitted to the Neonatal Intensive Care Unit (NICU). Primary aim: Assess the effects of VoiceLove on maternal postpartum depression, measured by the Edinburgh Postnatal Depression Scale (EPDS). The estimates from this study will be used for a future definitive Phase III trial. Secondary aim: Assess feasibility, acceptability, and patterns of communication and engagement among mothers, partners, and NICU clinicians during the NICU hospitalization, measured through app usage metrics, satisfaction surveys, and qualitative interviews. Additionally, we will evaluate effects of infant length of stay.",[28,29,30,31,32,33],"Postpartum Depression (PPD)","Self-Efficacy","Parental Anxiety","Engagement, Patient","Usability","Length of Stay",[35,36,28,37,15,38],"Neonatal Intensive Care Unit","NICU","VoiceLove app","VoiceLove","RECRUITING","2026-06-15",{"date":42,"type":43},"2026-06-17","ACTUAL",{"date":45,"type":43},"2026-02-04",{"date":47,"type":22},"2028-01",{"name":49,"class":50},"Vanderbilt University Medical Center","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":60,"minAge":19,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":64,"briefSummary":65,"conditions":66,"keywords":71,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100621465","effect-of-clinical-hypnosis-in-preoperative-anxiety-among-patients-undergoing-an-abdominal-surgery-100621465","NCT07370974","Effect of Clinical Hypnosis in Preoperative Anxiety Among Patients Undergoing an Abdominal Surgery.","Effect of Clinical Hypnosis in Preoperative Anxiety Among Patients Undergoing an Abdominal Surgery : a Multicenter Randomized Controlled Trial.","Hypnoanxiety","* Inclusion Criteria:\n\n  1. Consenting patients undergoing abdominal surgery\n  2. ASA I-II physical status\n  3. Able to understand and respond to instructions\n  4. No major psychological disorders\n* Exclusion Criteria:\n\n  1. Non-consenting patients\n  2. Prior experience with hypnosis\n  3. History of mental illness\n  4. Psychoactive substance consumption\n  5. Cognitive disorders","ALL","80 Years",{"count":63,"type":22},48,[25],"This Multicenter randomized controlled trial evaluates clinical hypnosis efficacy for reducing perioperative anxiety and postoperative pain in abdominal surgery patients across 3 Moroccan centers (n=48-68). Intervention arm receives 15-20 min level 2 hypnosis session preoperatively; control receives standard psychological preparation. Primary outcome: VAS-anxiety post-intervention. Secondary: postoperative EVA-pain, analgesic consumption, length of stay.\n\nStudy Design Prospective, multicenter, parallel-group RCT (1:1 allocation, stratified by center\u002Fsex). Inclusion: consenting ASA I-II adults for abdominal surgery. Primary endpoint powered for 10mm EVA reduction (80% power, α=0.05). Registration supports PhD thesis at ISSS\u002FUniversité Hassan 1er Settat.",[67,68,69,70,33],"Hypnosis","Preoperative Anxiety","Postoperative Pain","Abdominal Surgeries",[72,73,67,74],"RCT","Morocco","preoperative anxiety","2026-05-30",{"date":77,"type":43},"2026-06-02",{"date":79,"type":43},"2026-02-07",{"date":81,"type":22},"2026-06-03",{"name":83,"class":50},"HASSAN 1st university",3,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":17,"sex":60,"minAge":19,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":95,"briefSummary":96,"conditions":97,"keywords":99,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":51},"100479254","preoperative-oral-hydration-in-the-ambulatory-arthroplasty-population-100479254","NCT05520593","Preoperative Oral Hydration in the Ambulatory Arthroplasty Population","Preoperative Oral Hydration in the Ambulatory Arthroplasty Population :A Single-Blinded Randomized Control Trial","Inclusion Criteria:\n\n* Candidates for ambulatory total knee arthroplasty\n* Candidates for ambulatory total hip arthroplasty\n* Candidates for ambulatory revision knee arthroplasty (liner exchange only)\n* Candidates for ambulatory revision hip arthroplasty (liner exchange only)\n* Case scheduled before noon (12 pm)\n* Patient agrees to same-day discharge and has a responsible adult to spend the night on the day of discharge\n\nExclusion Criteria:\n\n* BMI less than 18.5 or greater than 37.0\n* Patients with diabetes, chronic kidney disease, clotting disorders, or neurological conditions preventing control of the affected limb.\n* Pregnant women\n* Patients scheduled as ambulatory due to insurance mandates\n* Patients with a history of active ischemia, significant valvular disease, significant arrhythmias, obstructive sleep apnea as per Hospital for Special Surgery guidelines, chronic opioid dependence (chronic daily opioid use for six or more months), and glomerular filtration rate \\\u003C 60ml\u002Fmin.","75 Years",{"count":94,"type":22},312,[25],"The purpose of this study is to investigate if the consumption of a complex carbohydrate drink preoperatively, decreases the length of stay and causes for failure to launch in patients undergoing ambulatory total joint arthroplasty.",[98,33],"Same-day Discharge",[100,101,98,102,103,104,105,106],"Carbohydrate Drink","Perioperative Fluids","Total Joint Arthroplasty","Nausea","Vomiting","Same-day total hip arthroplasty","Same-day total knee arthroplasty","2026-04-08",{"date":109,"type":43},"2026-04-13",{"date":111,"type":43},"2022-11-07",{"date":113,"type":22},"2027-01",{"name":115,"class":50},"Hospital for Special Surgery, New York",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":60,"minAge":19,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":127,"conditions":128,"keywords":137,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":146,"leadSponsor":148,"locationsCount":51},"100624164","duke-virtual-integrated-workflow-100624164","NCT07406074","Duke Virtual IntEgrated Workflow","DUH Innovation Units","Duke VIEW","Inclusion Criteria:\n\n* Admission to the hospital on one of six clinical units\n\nExclusion Criteria:\n\n* Less than 18 years old",{"count":125,"type":22},10000,"OBSERVATIONAL","This quality improvement initiative aims to evaluate the implementation, utilization, and impact of virtual care technologies and workflows being implemented at Duke University Health System (DUHS). This project is embedded within operational workflows and is designed to inform strategic decision-making and resource allocation. The evaluation will focus on key performance indicators (KPIs) relevant to hospital operations and patient outcomes, including but not limited to: Length of Stay, Readmission Rates, Patient Satisfaction Scores, and Other Quality and Safety Metrics. These KPIs will be evaluated across three clinical units at Duke University Hospital, in which virtual care technologies are being implemented. These will be compared to three control units of similar characteristics. Differences in KPIs will be examined across all units over 12 months.",[129,130,131,132,133,134,135,136,33],"Falls Injury","Readmission Rates","CLABSI - Central Line Associated Bloodstream Infection","Catheter Associated Urinary Tract Infection","Hospital Acquired Pressure Injury","Venous Thromboembolism (VTE)","Nurses","Satisfaction, Patient",[138,139,140],"Virtual Care","Nursing","Inpatient","NOT_YET_RECRUITING","2026-02-09",{"date":144,"type":43},"2026-02-12",{"date":45,"type":22},{"date":147,"type":22},"2027-02-03",{"name":149,"class":50},"Duke University",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":60,"minAge":19,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":167,"leadSponsor":169,"locationsCount":51},"100603146","associations-between-time-to-reduction-and-complications-in-patients-with-dislocated-total-hip-arthroplasty-100603146","NCT07132723","Associations Between Time to Reduction and Complications in Patients With Dislocated Total Hip Arthroplasty","Associations Between Time to Reduction and Complications in Patients With Dislocated Total Hip Arthroplasty - A Protocol for an Observational Cohort Study","Inclusion Criteria:\n\nPatients will be considered eligible for inclusion if they meet all of the following criteria:\n\n* Aged 18 years or older\n* Presented to the emergency department with a dislocated total hip arthroplasty.\n* Undergo closed reduction of the dislocated total hip arthroplasty in the operating theatre, with the involvement of the Department of Anesthesiology.\n\nExclusion Criteria:\n\n* Were primarily booked for open surgical reduction.\n* Did not have a complete case log (i.e. time of admission; referral to the operation theatre; anesthesia induction; discharge, etc.) and we were unable to recreate the log using simple code rules.",{"count":158,"type":22},3700,"The aim of the study is to investigate the impact of time to closed reduction on both patient related and organizational factors. These include, length of stay, hospitalization, admission to intensive care unit, rehospitalizations, delirium, all-cause mortality, infection requiring hospital contact, and cardiovascular complications. It is also intended to investigate whether different anaesthetic strategies and airway management are associated with different complication rates.\n\nIt is hypothesized that longer waiting time until reduction increase the postoperative length of stay, readmissions, and risk of complications.",[161,162,33],"Closed Reduction","Arthroplasty, Replacement, Hip","2025-08-11",{"date":165,"type":43},"2025-08-20",{"date":165,"type":22},{"date":168,"type":22},"2025-10-01",{"name":170,"class":50},"Nordsjaellands Hospital",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":175,"acronym":176,"eligibilityCriteria":177,"healthyVolunteers":17,"sex":60,"minAge":178,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":23,"phases":182,"briefSummary":184,"conditions":185,"keywords":188,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":207},"100584790","phase-3-limited-versus-extended-trophic-feeding-let-feed-trial-100584790","NCT06893939","Limited Versus Extended Trophic Feeding (LET-FEED) Trial","LET-FEED","Inclusion Criteria:\n\n* \\\u003C1500 gram birthweight\n* 25w0d-31w6d at birth\n* Consent to feed donor milk when parent's own milk is not available or of insufficient quantity\n\nExclusion Criteria:\n\n* \\\u003C5th percentile for weight at birth (Fenton growth curve)\n* Parent or legal guardian unable to provide consent within 36 hours after birth\n* Congenital anomaly affecting decisions on enteral feedings (e.g. gastroschisis, omphalocele, congenital diaphragmatic hernia, congenital heart disease, etc.)\n* Known genetic condition affecting growth, feeding, or mortality\n* Vasopressor use within first 24 hours after birth (not including hydrocortisone)\n* Considered terminally ill","0 Hours","36 Hours",{"count":181,"type":22},350,[183],"PHASE3","Study Hypothesis\u002FQuestion In infants born very preterm, advancing enteral feeds after 24 hours from birth (limited trophic feeds) versus after 72 hours (extended trophic feeds) reduces the risk of all-cause late onset sepsis (LOS) without increasing the risk of other adverse outcomes.\n\nStudy Design Type This is a multi-center, open-label, parallel-group, individual randomized controlled trial comparing two different trophic feeding regimens in preterm infants born between 25w0d and 31w6d. These infants will be randomly assigned to either the intervention group, receiving limited trophic feeding (20 to 25 mL\u002Fkg\u002Fday for one day) or the control group, receiving extended trophic feeding (20 to 25 mL\u002Fkg\u002Fday for three days) prior to advancing enteral feeds until full feeding volume (140 mL\u002Fkg\u002Fday) is achieved.\n\nEligibility Criteria Preterm infants with gestational ages between 25 0\u002F7 and 31 6\u002F7 weeks and a birthweight of \\\u003C1500 grams who are admitted to six participating neonatal units will be eligible for inclusion. Infants with \\\u003C5th percentile for weight at birth, vasopressor use within first 24 hours of life major congenital\u002Fgenetic anomalies affecting enteral feeding, growth, or mortality, and those with a terminal illness in which decisions to withhold or limit support have been made will be excluded. Infants of parents or legal guardians who are unable to provide consent within 36 hours of birth will also be excluded.\n\nStudy Intervention\u002FMethods Written parental informed consent will be obtained prenatally or within the first 36 hours of birth. Infants will be randomized to receive limited trophic feeds of 24 to 36 hours or extended trophic feeds for 72 hours prior to the advancement of enteral feeds. Infants will be fed parent's own milk (POM) with donor human milk as the alternative if POM is unavailable.\n\nPrimary Outcome Late-onset sepsis, defined as positive blood, urine, and\u002For cerebrospinal fluid (CSF) cultures in the presence of compatible clinical signs of sepsis, occurring after postnatal day 3 and before hospital discharge, and treated with antibiotics for 5 days or more.\n\nSecondary Outcome(s) The trial will assess various secondary outcomes including length of hospital stay, all-cause in-hospital mortality, duration of IV fluids and central line utilization, necrotizing enterocolitis (Bell's stage IIa or higher), severe intraventricular hemorrhage (grade III or IV either unilaterally or bilaterally), bronchopulmonary dysplasia (oxygen requirement or positive pressure ventilation at 36 weeks corrected gestational age), or retinopathy of prematurity requiring intervention. Additionally, growth metrics throughout hospitalization will be evaluated using change in weight, length, and head circumference z-scores from birth to 36 weeks' corrected gestational age between infants in the limited and extended trophic feeding groups.",[186,33,187],"Sepsis","Mortality",[189,190,191,192,193,194,195,196,197],"Feeding","Nutrition","Prematurity","Very preterm","Trophic","Trophic feeds","Trophic feeding","enteral feeds","sepsis","2025-07-23",{"date":200,"type":43},"2025-07-28",{"date":202,"type":43},"2025-07-03",{"date":204,"type":22},"2028-03-31",{"name":206,"class":50},"University of Washington",6,{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":11,"sex":60,"minAge":216,"maxAge":217,"enrollmentInfo":218,"targetDuration":4,"studyType":23,"phases":220,"briefSummary":221,"conditions":222,"keywords":223,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":236},"100457023","alberta-collaborative-qi-strategies-to-improve-outcomes-of-moderate-and-late-preterm-infants-abc-qi-trial-100457023","NCT05231200","Alberta Collaborative QI Strategies to Improve Outcomes of Moderate and Late Preterm Infants (ABC-QI Trial)","Alberta (AB) Collaborative Quality Improvement Strategies to Improve Outcomes of Preterm Infants 32 - 36 Weeks' Gestation: A Stepped-Wedge Cluster Randomized Trial","ABC-QI","Inclusion Criteria:\n\nPreterm Infants: Infants born at 32 to 36 weeks' gestation and admitted to the participating NICUs or postpartum units.\n\nQuality Improvement Implementation Survey version 2 (QIIS-II) and semi-structured interview participants: Management staff, nurses, nurse practitioners, physicians, and allied health staff employed in participating NICUs.\n\nExclusion Criteria:\n\n* Preterm Infants:\n\n  * Major congenital anomalies or chromosomal abnormalities.\n  * Primary admission to a surgical NICU: Alberta Children's Hospital or Stollery Children's Hospital.\n  * Infants born in or transferred to a NICU outside Alberta.\n  * Patients who have imposed confidentiality restrictions on accessing their health records.","32 Weeks","36 Weeks",{"count":219,"type":22},9500,[25],"The ABC-QI Trial aims to implement collaborative quality improvement (QI) strategies to standardize care for 32-36 week infants in Level 2 and 3 Neonatal intensive care units (NICUs) across the province of Alberta. The investigators want to know if using validated quality improvement methods and evidence-based care bundles will decrease the duration of hospital stay and get babies home as quickly as possible.",[33],[224,225,226],"Preterm infants","Evidence-based Practice for Improving Quality","Neonatal intensive care units","2025-07-15",{"date":229,"type":43},"2025-07-18",{"date":231,"type":43},"2023-05-01",{"date":233,"type":22},"2027-08-30",{"name":235,"class":50},"University of Calgary",12,{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":243,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":60,"minAge":245,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":248,"conditions":249,"keywords":252,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":262,"leadSponsor":264,"locationsCount":51},"100588832","nutritional-status-and-patient-characteristics-upon-length-of-stay-clinical-outcome-and-survival-in-older-hospitalized-patients-100588832","NCT06946537","Nutritional Status and Patient Characteristics Upon Length of Stay, Clinical Outcome, and Survival in Older Hospitalized Patients","The Influence of Nutritional Status and Phenotypic Characteristics Upon Length of Stay, Clinical Outcome, and Survival in Hospitalized Patients","INSIGHT","Inclusion Criteria:\n\n* Acutely admitted adults aged 65 years and above.\n* Be able to comply with the study information, as assessed by the research personnel.\n* Be able to understand Danish.\n\nExclusion Criteria:\n\n* \\\u003C24 hours admission\n* Terminal illness in end stage of life\n* Patients with temporary civil person registration number (CPR)","65 Years",{"count":247,"type":22},1500,"Disease-related malnutrition (DRM) describes undernutrition or imbalances in energy, protein, or other nutrient-needs, caused by a concomitant disease. Nutritional status plays a vital role in the fate of hospitalized patients, and DRM is associated with loss of function and decreased survival.\n\nDRM is a common condition in patients with acute illnesses, approximately 30% among medical inpatients are malnourished when admitteed to the hospital, and rise higher among the older or critically ill. Physiologically malnutrition is associated with a) poorer tissue healing and restitution after severe disease, b) suppressed immune function and resistance towards infections, c) poorer metabolic defense towards critical disease, d) delayed and poorer progress of chronic diseases. In addition, inadequate nutrition is coupled to a prolonged hospital stay, resulting in more readmissions, and overall higher mortality in hospital patients. Yet, nutritional status of patients upon hospital admittance is seldom systematically assessed and the consequences of DRM in older acutely admitted patients still needs to be understood.\n\nThis project will provide a detailed description of nutritional, physiolgical, and biochemical status of 1500 acutely admitted patients. In relation, the study will investigate the relation between patient characteristics and disease progression. The obtained data will also be coupled to patient registers to investigate the link between length of hospital stay, readmissions and acute contact, and mortality.",[250,251,33],"Geriatric","Malnutrition",[250,253,254,255,256,257],"Disease-related malnutrition","Physiology","Acute illness","Deep phenotyping","Nutritional status","2025-05-12",{"date":260,"type":43},"2025-05-14",{"date":258,"type":43},{"date":263,"type":22},"2028-11",{"name":265,"class":50},"Bispebjerg Hospital",{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":272,"eligibilityCriteria":273,"healthyVolunteers":11,"sex":60,"minAge":19,"maxAge":4,"enrollmentInfo":274,"targetDuration":4,"studyType":23,"phases":276,"briefSummary":278,"conditions":279,"keywords":289,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":51},"100587065","phase-4-intravenous-acetaminophen-to-reduce-post-operative-opioid-consumption-100587065","NCT06923540","Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption","Evaluating the Impact of IV Acetaminophen on Opioid Consumption in the Postoperative Period in Patients Undergoing Abdominal Surgery","ACETAPOP","Inclusion Criteria:\n\n* Age 18 years or older.\n* Underwent abdominal surgery\n* Underwent elective surgery.\n* Hospitalized in the digestive surgery, hepatobiliary and pancreatic surgery, or gynecology and gynecologic oncology units at CHUM.\n* Declared NPO immediately post-surgery, meaning they cannot take oral medications.\n\nExclusion Criteria:\n\n* Hypersensitivity to acetaminophen or an excipient in the administered formulations\n* Hepatic insufficiency with a Child-Turcotte-Pugh score of B or C.\n* Weight \\\u003C 50 kg (patients requiring a lower acetaminophen dose).\n* Active pregnancy or breastfeeding.\n* Opioid use disorder (OUD) under active treatment\n* Non-opioid-naïve patients: those who received a long-acting opioid within seven days preceding surgery. This criterion will be verified through patient interviews and cross-checked with medical records.\n* Use of illicit recreational substances.\n* Prior participation in this study.\n* Ectopic patients: physically located in a unit other than digestive surgery (11 South), hepatobiliary and pancreatic surgery (14 South), or gynecology and gynecologic oncology (12 South).",{"count":275,"type":22},140,[277],"PHASE4","Acetaminophen (Tylenol) is a commonly used medication after surgery to control pain. Tablets for oral use and suppositories for rectal use are the most frequently employed forms of acetaminophen after surgery. Intravenous (IV) acetaminophen is widely used in several countries but is not a standard medication for the adult population in Canada. It is mainly considered when it is impossible to take medication in tablet or suppository form. Opioids (Morphine, Hydromorphone, Oxycodone, etc.) are another class of medications commonly used after surgery for pain management. While they are generally very effective and stronger than acetaminophen or other pain relievers (e.g., ibuprofen\u002FAdvil), reducing their use is preferable, as they can cause various side effects such as nausea, dizziness, and dependence. IV acetaminophen may help control pain while also reducing opioid consumption. However, there are few high-quality scientific studies proving the benefits of IV acetaminophen compared to other forms, such as tablets or suppositories. Acetaminophen has been available in Canada for many years and has already been recommended for use in Quebec by the Institut national d'excellence en santé et services sociaux (INESSS) under certain conditions. This study aims to validate its benefits with clear data.",[280,281,282,70,283,284,285,286,287,33,288],"Post Operative Analgesia","Opioid Consumption, Postoperative","Acetaminophen","Post Operative Bowel Dysfunction","Post Operative Nausea and Vomiting","Post Operative Pain Control","Mobility","Epidural Analgesia","Pain Management",[290,291,292,293,294,295,296,297,298,299,300,301,302,303,304,305,306],"IV acetaminophen","intravenous acetaminophen","acetaminophen","post operative analgesia","nil per os","npo","post operative pain","opioid consumption","abdominal surgery","hepato-biliary surgery","digestive surgery","pancreatic surgery","gynecologic surgery","post operative nausea and vomiting","post operative mobility","hospitalization length of stay","co-analgesia","2025-04-04",{"date":309,"type":43},"2025-04-11",{"date":311,"type":22},"2025-04-28",{"date":313,"type":22},"2025-08-15",{"name":315,"class":50},"Centre hospitalier de l'Université de Montréal (CHUM)",{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":320,"acronym":321,"eligibilityCriteria":322,"healthyVolunteers":11,"sex":60,"minAge":19,"maxAge":4,"enrollmentInfo":323,"targetDuration":4,"studyType":23,"phases":325,"briefSummary":326,"conditions":327,"keywords":330,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":51},"100326281","automated-oxygen-administration-in-patients-with-hypoxemic-pneumonia-and-pleuropneumonia-100326281","NCT03527992","Automated Oxygen Administration in Patients With Hypoxemic Pneumonia and Pleuropneumonia","OPPAÎ","Inclusion Criteria:\n\n* Adult\n* Patient living at home or in an institution\n* Patient hospitalized for less than 48 hours\n* Pneumonia defined (according to the 2006 French-speaking infectious pneumology society (SPILF) criteria) by:\n\n  * respiratory functional symptoms (cough, sputum, dyspnea, chest pain) and\n  * Hyperthermia \\>38,5°C or hypothermia \\\u003C36°C and\n  * Radiological Signs of Pneumonia\n* Hypoxia : SpO2 \\\u003C 94% in ambient air and\u002For PaO2\\\u003C 60 mmHg in ambient air\n\nExclusion Criteria:\n\n* Pneumonia acquired at the hospital.\n* Patient hospitalized in another department more than 48 hours before admission\n* Chronic respiratory failure\n* Active neoplasia\n* Patients undergoing oxygen therapy and \u002F or long-term NIV\n* Associated cardiac decompensation (clinical signs and \u002F or NTproBNP\\> 1800ng \u002F mL) (3\n* Initial Need for high flow oxygen therapy or ventilatory support (NIV, VI)\n* Difficulties expected from home support.",{"count":324,"type":22},128,[25],"Hypoxemic pneumonia is a major cause of hospitalization in Pulmonology. The patient's dependency on oxygen prevents early discharge from the hospital. An automated oxygen therapy is a system that allows administration of oxygen with a flow that is automatically adjusted to the patient's saturation, which is continuously monitored. This system has proven to be particularly effective with chronic obstructive pulmonary disease (COPD) patients, by decreasing the time spent in hypoxia and hyperoxia, and by accelerating the weaning of oxygen. Our hypothesis is that automated oxygen therapy leads to a diminution on the length of hospital stay.",[328,329,33],"Pneumonia","Pneumonia, Ventilator-Associated",[331,332,333,334,335],"Randomized Therapeutic trial","Hypoxemic pneumonia","Automated oxygen therapy","Length of stay","medico-economic cost","2024-08-01",{"date":338,"type":43},"2024-08-02",{"date":340,"type":43},"2018-03-09",{"date":342,"type":22},"2028-10",{"name":344,"class":50},"University Hospital, Toulouse"]