[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"leptin-resistance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:leptin-resistance":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,57],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":5},"100587695","reprogramming-energy-homeostasis-in-overweight-individuals-via-exercise-cognitive-and-social-training-100587695",false,"NCT06931730","Reprogramming Energy Homeostasis in Overweight Individuals Via Exercise, Cognitive, and Social Training","Reprogramming Energy Homeostasis in Overweight Children and Adults Trough Exercise, Cognitive Training and Social Interaction","Resilient","Inclusion Criteria:\n\n* a condition of overweight or obesity\n* Intelligence Quotient (IQ) ≥ 85\n\nExclusion Criteria:\n\n* genetic or syndromic obesity;\n* reduced mobility;\n* systemic diseases;\n* ongoing pharmacological treatment for chronic conditions.","ALL","6 Years","11 Years",{"count":21,"type":22},240,"ESTIMATED","INTERVENTIONAL",[25],"NA","The RESILIENT project is a clinical trial investigating leptin sensitivity in both children and adults with overweight or obesity. The study examines the additive effects of Cognitive Training (CT) and Social Training (ST) on leptin sensitivity, compared to stand-alone Intensive Health Behaviour Treatment (IHBT), which includes diet and Physical Activity (PA).\n\nThe intervention will last for 8 weeks, followed by a 12-week washout period. A multilevel assessment will be conducted, evaluating in vivo leptin sensitivity (through the ratio of leptin levels to caloric intake) as well as ex vivo molecular analysis of leptin signaling in Peripheral Blood Mononuclear Cells (PBMCs). Additionally, clinical, psychological, cognitive, and physiological assessments will be performed to assess the efficacy of each intervention. By investigating leptin resistance as a potential molecular bridge between metabolic dysregulation and cognitive dysfunctions, this study may contribute to the development of more effective, long-term treatments for obesity and overweight. Additionally, in vivo investigation of leptin sensitivity may be particularly important for providing evidence of the metabolic and cognitive effects necessary for developing novel anti-obesity treatments.",[28,29,30],"Obesity and Overweight","Leptin Resistance","Childhood Obesity",[32,33,34,35,36,37,38,39,40,41,42,43,44],"childhood obesity","cognitive training","social training","environmental enrichment","leptin","lifestyle modification","overweight","obesity","energy expenditure","thermogenesis","physical activity","leptin sensitivity","leptin resistance","RECRUITING","2025-04-09",{"date":48,"type":49},"2025-04-17","ACTUAL",{"date":51,"type":49},"2024-02-08",{"date":53,"type":22},"2025-12-31",{"name":55,"class":56},"Bambino Gesù Hospital and Research Institute","OTHER",{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":4,"maxAge":4,"enrollmentInfo":67,"targetDuration":4,"studyType":23,"phases":69,"briefSummary":72,"conditions":73,"keywords":80,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":99},"100582190","phase-1-impact-of-chromium-supplementation-on-glucido-lipidic-metabolism-oxidative-stress-and-inflammatory-state-in-patients-with-gestational-diabetes-100582190","NCT06860087","Impact of Chromium Supplementation on Glucido-lipidic Metabolism, Oxidative Stress and Inflammatory State in Patients with Gestational Diabetes","Impact of Chromium Supplementation on Glucido-lipidic Metabolism, Oxidative Stress and Inflammatory State in Pregnant Women with Gestational Diabetes Mellitus","Cr and GDM","Inclusion Criteria:\n\n* Healthy pregnant women:\n\n  * Whose their gestational age is 28 weeks\n  * They have no pathology or complication associated with their pregnancy.\n* Pregnant women with gestational diabetes mellitus:\n\n  * They will be selected according to the criteria of the one-step method for screening for gestational diabetes mellitus established by the WHO.\n  * They have no other pathology or complication associated with pregnancy.\n  * They are subjected to insulin therapy and a low-calorie diet, rich in protein, fiber and beneficial lipids (they will all asked to keep their medical treatment prescribed by their doctor).\n* All women involved in this study will be systematically supplemented with 60 mg\u002Fd iron and 400 mg\u002Fd vitamin B9 during pregnancy as recommended by WHO.\n\nExclusion Criteria:\n\n* Pregnant women with unrecognized diabetes, type I or type II, will not be involved in this study.\n* Pregnant women who were supplemented before one month or during pregnancy, or who will need other micronutrient supplements during the study to avoid their influence on the results.\n* Pregnant women who develop other health complications will be removed from the study and replaced by others.\n* Women with gestational diabetes mellitus who were unable to complete chromium supplementation up to 6 weeks will be excluded from the study and replaced by others.",true,"FEMALE",{"count":68,"type":22},200,[70,71],"PHASE1","PHASE2","Our study aims to explore the influence of dietary chromium supplementation in the form of chromium picolinate, at different doses (200 µg and 400 µg per day), on the health of pregnant women with gestational diabetes. This study will also provide more information on the safety of this type of supplementation during pregnancies complicated by gestational diabetes mellitus.\n\nThe main questions it aims to answer are:\n\n* Does chromium supplementation at various doses in women with gestational diabetes mellitus truly influence their glucido-lipidic metabolism, oxidative\u002Fantioxidant balance, and inflammatory state? If so, is it beneficial or detrimental?\n* If this supplementation is beneficial, which dose is the most appropriate?\n* Do these types of supplementation have any side effects on the health of the mother and fetus? The participants will take chromium supplements for 6 weeks (supplemented groups) while the control participants will not take them (healthy and diabetic control groups).\n\nChromium-supplemented participants will undergo a medical check-up every 02 weeks to closely monitor their health status and detect any potential side effects at an early stage.\n\nResearchers will compare the biochemical profile, oxidative stress status, and inflammation markers between chromium-supplemented and non-supplemented participants to assess the impact of this trace element.\n\nResearchers will compare the effects of chromium supplements at different doses with each other.",[74,75,76,77,29,78,79],"Gestational Diabetes Mellitus (GDM)","Oxidative Stress","Inflammatory Status","Insulin Resistance","Glucose Metabolism Disorder","Lipid Metabolism Disorders",[81,82,83,84,85,86,87,88],"Inflammatory status markers","Oxidative stress markers","Glucido-lipidic metabolism","HOMA-IR","Leptin level","Lipid profile","Fasting plasma glucose","Insulin level","NOT_YET_RECRUITING","2025-03-01",{"date":92,"type":49},"2025-03-05",{"date":94,"type":22},"2025-05",{"date":96,"type":22},"2026-01",{"name":98,"class":56},"University of Kasdi Merbah",1]