[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"leptomeningeal-disease-lmd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:leptomeningeal-disease-lmd":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100629600","csf-and-blood-plasma-liquid-biopsy-in-patients-with-metastatic-solid-tumours-and-cns-metastases-or-no-cns-metastases-100629600",false,"NCT07476781","CSF and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and CNS Metastases or no CNS Metastases","Exploring the Feasibility of Cerebrospinal Fluid (CSF) Liquid Biopsy in Patients With Metastatic Solid Tumours and Leptomeningeal Disease (Cohort A), Parenchymal Brain Metastases (Cohort B), or No Evidence of Central Nervous System (CNS) Metastases (Cohort C): A Pilot Study","Inclusion Criteria:\n\n* Diagnosed with a metastatic solid tumour in one of the following scenarios:\n\n  1. Patients in Cohort A will have previously untreated or progressing leptomeningeal metastatic disease (LMD) with or without parenchymal brain metastases (BrM).\n  2. Patients in Cohort B will have previously untreated or BrM but no evidence of LMD.\n  3. Patients in Cohort C will have progressing extra-cranial metastatic disease with no LMD or BrM.\n* Patient is suitable for lumbar puncture and\u002For has an Ommaya reservoir that is accessible for CSF collection.\n* Patient is eligible at any time point in their treatment course, including whether or not they have already started treatment for LMD. Considering the poor prognosis associated with LMD, rapid clinical deterioration, and the fact that available local and systemic therapies have not been shown to completely eradicate LMD, there is a high likelihood of detecting CSF biomarkers regardless of the timing of assessment. This flexible enrollment strategy is particularly important to support feasibility and recruitment in this less common and clinically challenging population. However, efforts will be made to collect CSF samples prior to treatment initiation and\u002For at the time of disease progression whenever possible.\n* Patients with active brain metastases, defined as newly diagnosed and previously untreated lesions, or lesions that were previously treated and are now progressing.\n* Patients who were previously enrolled in the study and had negative CSF biomarkers may be re-enrolled at a later time point (e.g., upon progression of CNS disease).\n\nExclusion Criteria:\n\n* Inability to understand or unwillingness to provide written informed consent (language barriers are not exclusionary; the use of a translator is permitted).\n* Patients with contraindications to lumbar puncture (e.g., infection at the LP site, uncontrolled bleeding diathesis \\> 1.5\\], severe thrombocytopenia \\[platelet count \\\u003C40,000\u002FµL\\], use of anticoagulant or antiplatelet medications cannot be safely interrupted, significant mass effect with risk of herniation, or presence of vertebral hardware)","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is a prospective, single-centre feasibility study of CSF ctDNA conducted at the Sunnybrook Odette Cancer Centre (SOCC), Toronto, Canada, including multiple solid tumor, stratified into cohorts according to CNS disease involvement, including leptomeningeal disease (Cohort A), parenchymal brain metastases (Cohort B), and no evidence of CNS metastases (Cohort C).",[26,27,28],"Solid Tumor Malignancies","Brain Metastasases","Leptomeningeal Disease (LMD)","RECRUITING","2026-06-23",{"date":32,"type":33},"2026-06-26","ACTUAL",{"date":35,"type":33},"2025-12-12",{"date":37,"type":20},"2026-12",{"name":39,"class":40},"Sunnybrook Health Sciences Centre","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":73},"100318276","phase-1-a-study-to-assess-the-safety-and-tolerability-of-azd1390-given-with-radiation-therapy-in-patients-with-brain-cancer-100318276","NCT03423628","A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer","A Phase I, Multicenter Study to Assess the Safety, Tolerability, and Pharmacokinetics of Ascending Doses of AZD1390 in Combination With Radiation Therapy in Patients With Glioblastoma Multiforme and Brain Metastases From Solid Tumors","Inclusion Criteria:\n\n* Provision of formalin-fixed paraffin embedded tissue sample from primary or metastatic disease\n* Karnofsky Performance Score of ≥60.\n* Additional Inclusion Criteria Specific for Arm A and Japan:\n\n  * Histologically proven diagnosis of GBM. Patients who have had RT for low-grade glioma (LGG) or grade 3 glioma and have subsequently relapsed to histologically confirmed GBM can be considered\n  * A radiological diagnosis of recurrent\u002Frelapsed or progressive disease according to RANO criteria.\n  * Completion of first-line radiation at least 6 months prior to Cycle 1 Day 1.\n  * Patients with tumor-induced seizures must be well controlled on a stable anti-epileptic treatment\n  * Willing to receive anti-epileptic prophylaxis for the duration of study drug administration.\n* Additional Inclusion Criteria Specific for Arm B:\n\n\\*\\*Arm B has now closed to recruitment\\*\\*\n\n* Histologically proven diagnosis of solid tumor malignancy and Magnetic Resonance (MR) imaging documenting brain lesions.\n* Not eligible for Stereotactic Radiosurgery (SRS) treatment of brain tumor.\n* Patient has not received any previous brain RT to the area that is to be irradiated. Prior PBRT may be allowed if there is not significant overlap between the prior and new radiation fields.\n* Non-CNS malignant disease must be sufficiently controlled so that patients can be without additional systemic therapy for the required washout period before starting therapy until 5 days after the end of RT. Required washout period before starting the first dose of AZD1390 (Cycle 1) is 28 days for immune checkpoint inhibitors and 7 days for all other agents\n* Not received radiation to the lung fields within the past 8 weeks.\n* No history of seizures related to the brain metastases or LMD.\n* Receiving PBRT (rather than WBRT) during Cycle 1 as standard of care for brain metastases\n\n  • Additional Inclusion Criteria Specific for Arm C:\n* Histologically proven primary diagnosis of GBM with unmethylated O6-methylguanine-DNA methyltransferase (MGMT). Grade 4 astrocytoma or histology with molecular features of GBM can be considered.\n* Determination of MGMT promoter status by methylation-specific polymerase chain reaction (PCR) or pyrosequencing per local institutional guidelines is required to assess eligibility for this Arm.\n* Patients will have to undergo mutational testing for Isocitrate dehydrogenase 1 (IDH1) on a tumor specimen before entering study. Patients are eligible for Arm C regardless of their IDH1 mutational status.\n* No history of uncontrolled seizures after surgery for primary GBM (despite adequate antiepileptic therapy) or with need for concurrent administration of more than 2 antiepileptic drugs.\n* Willing to receive anti-epileptic prophylaxis for the duration of study drug administration\n\nAdditional Inclusion criteria for Food Effect Assessment (Arm A):\n\n* For the fed assessment portion: fast overnight (for at least 10 hours) prior to consuming a high-fat meal consisting of approximately 800 to 1000 calories, with around 54% of the calories coming from fat.\n* For the fasted assessment portion: fast overnight (for at least 10 hours prior to dosing) and until 4 hours after dosing.\n\n\\*Note: the optional food effect assessment is currently open to enrolment\\*\n\nExclusion Criteria:\n\n* Administration of chemotherapy or any investigational drug in the 28 days or carmustine (CCNU) or lomustine (BCNU) in the 6 weeks prior to receiving the first dose of treatment in Arms A and C. Administration of checkpoint inhibitors within 28 days prior to first dose of treatment and any other agent within 7 days of beginning study treatment in Arm B. Hormonal therapies are allowed during study treatment for patients in Arm B.\n* History of severe brain-injury or stroke.\n* Patient not eligible for sequential MRI evaluations are not eligible for this study.\n* History of epileptic disorder or any seizure history unrelated to tumor\n* Treatment with Strong inhibitors or inducers of CYP3A4 within 2 weeks prior to receiving study drug\n* Concurrent therapy with other seizurogenic medications.\n* Past medical history of interstitial lung disease (ILD), drug-induced ILD, radiation pneumonitis which required steroid treatment, or any evidence of clinically active ILD.\n* Concurrent severe and\u002For uncontrolled medical condition (e.g., severe COPD).\n* Prior treatment with pneumotoxic drugs, e.g. busulfan, bleomycin, within the past year. If prior therapy in lifetime, then excluded if history of pulmonary toxicities from administration. Patients who have received treatment with nitrosoureas (e.g., carmustine, lomustine) in the year before study entry without experiencing lung toxicity are allowed on study.\n* History or presence of myopathy or raised creatine kinase (CK) \\>5 x upper limit of normal (ULN) on 2 occasions at screening.\n* Cardiac dysfunction defined as: Myocardial infarction within six months of study entry, NYHA (New York Heart Association) Class II\u002FIII\u002FIV heart failure, unstable angina, unstable cardiac arrhythmias\n* Evidence of severe pulmonary infections, as judged by the investigator (For Japan part only this includes active infection including tuberculosis, chronic active or uncontrolled Hep B or Hep C)\n* With the exception of alopecia, any unresolved toxicities from prior therapy greater than National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE 4.03) Grade 1 at the time of starting study treatment and patients with chronic Grade 2 unresolved toxicities may be eligible Additional exclusion criteria for Arm A and Japan Part\n* Has previously received ATM inhibitor with concurrent RT\n\nAdditional Exclusion criteria for Food Effect Assessment (Arm A) (Not applicable for the Japan Part):\n\n* Diabetes Type I, Type II, or steroid-induced diabetes.\n* Undergoing systemic steroid treatment \\*Note: the food effect assessment is currently open to enrolment\\*","130 Years",{"count":51,"type":20},180,[53],"PHASE1","This study will test an investigational drug called AZD1390 in combination with radiation therapy for the treatment of brain tumors. This is the first time AZD1390 is being given to patients. This study will test safety, tolerability and PK (how the drug is absorbed, distributed and eliminated) of ascending doses of AZD1390 in combination with distinct regimens of radiation therapy",[56,57,58,28],"Recurrent Glioblastoma Multiforme","Primary Glioblastoma Multiforme","Brain Neoplasms, Malignant",[60,61,62],"glioblastoma","Ataxia-telangiectasia mutated kinase (ATM) inhibition","radiation therapy","2025-12-19",{"date":65,"type":33},"2025-12-22",{"date":67,"type":33},"2018-04-02",{"date":69,"type":20},"2026-09-16",{"name":71,"class":72},"AstraZeneca","INDUSTRY",12]