[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lidocaine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lidocaine":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,46,76,104,131,161,187,214,240,264,289,311,334,354],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100644957","hemodynamic-effect-of-dexmedetomidine-versus-magnesium-sulphate-as-an-adjuvant-to-lidocaine-in-preemptive-peribulbar-block-in-patients-undergoing-dacryocystorhinostomy-under-general-anesthesia-100644957",false,"NCT07675616","Hemodynamic Effect of Dexmedetomidine Versus Magnesium Sulphate as an Adjuvant to Lidocaine in Preemptive Peribulbar Block in Patients Undergoing Dacryocystorhinostomy Under General Anesthesia","Hemodynamic Effect of Dexmedetomidine Versus Magnesium Sulphate as an Adjuvant to Lidocaine in Preemptive Peribulbar Block in Patients Undergoing Dacryocystorhinostomy Under General Anesthesia: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Undergoing elective Dacryocystorhinostomy (DCR) surgery under general anesthesia.\n\nExclusion Criteria:\n\n* Patients have local infection.\n* Allergic reaction or complications of the local anaesthesia (LA).\n* Coagulopathy defined as international normalized ratio (INR) \\> 1.5, platelet count \\\u003C 100,000\u002Fmm³, or ongoing anticoagulant therapy not adequately discontinued.\n* Uncontrolled systemic disease, defined as poorly controlled hypertension \\[systolic blood pressure (SBP) \\> 160 mmHg\\], uncontrolled diabetes mellitus (HbA1c \\> 8.5%), unstable ischemic heart disease, or decompensated hepatic or renal disease.\n* Uncooperative patients.","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to compare the hemodynamic effect of dexmedetomidine and magnesium sulphate as an adjuvant to lidocaine in preemptive peribulbar block in patients undergoing Dacryocystorhinostomy (DCR) under general anaesthesia (GA) .",[26,27,28,29,30,31,32],"Hemodynamic Effect","Dexmedetomidine","Magnesium Sulphate","Lidocaine","Peribulbar Block","Dacryocystorhinostomy","General Anesthesia","RECRUITING","2026-06-27",{"date":36,"type":37},"2026-06-30","ACTUAL",{"date":39,"type":37},"2026-05-16",{"date":41,"type":20},"2026-12-01",{"name":43,"class":44},"Cairo University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":45},"100361323","phase-3-evaluation-of-the-analgesia-by-serratus-plane-block-during-pleural-drainage-in-intensive-care-unit-100361323","NCT03984656","Evaluation of the Analgesia by Serratus Plane Block During Pleural Drainage in Intensive Care Unit.","SERRATUS","Inclusion Criteria:\n\n* patients over 18 years old.\n* non-intubated patient with spontaneous ventilation\n* free and informed consent of the patient,\n* affiliated to a social security scheme\n* hospitalized in ICU unit including surgical ICU, cardiothoracic and respiratory ICU or cardiothoracic and respiratory continuous care unit.\n* requiring pleural drainage gas or fluid\n* conscious patient, not sedated.\n\nExclusion Criteria:\n\n* patient under the age of 18 years old.\n* patient refusal\n* under curatorship or deprivation of liberty\n* pregnant, parturient or breastfeeding woman\n* contraindication to Lidocaine or Ropivacaine\n* coagulation disorders",{"count":54,"type":20},70,[56],"PHASE3","Pleural drainage under local anesthesia is a frequent practice in resuscitation, experienced as an unpleasant and painful event for patients. Pain management is an important issue for early rehabilitation, decrease hospitalisation's cost and shortening the length of stay in intensive care unit (ICU). A new type of locoregional anesthesia called Serratus plane block described by Blanco in 2013 showed a benefit in per and postoperative analgesia in thoracic surgery and carcinologic breast surgery, allowing a decrease in morphine use and an improvement of the patient's general satisfaction. Serratus plane block is a very effective technique in chest wall analgesia, easy and safe to perform, with few complications. No studies to date have evaluated this anesthetic practice in intensive care for pleural drainage. This technique could be used outside the operating room to improve the intensive care patients, who often have heavier pathologies and greater pain, such as patients with chest trauma or patients with cardiac or respiratory disease. The investigators would like to conduct a preliminary study of superiority in the CHU Amiens intensive care unit, to study the interest of the Serratus plane block in comparison with local anesthesia on the management of acute pain during pleural drainage.",[59,29,60],"Analgesia","Intensive Care Unit",[62,63,64,65,66],"serratus plane block","analgesia","pleural drainage","lidocaine","intensive care unit","2026-05-12",{"date":69,"type":37},"2026-05-13",{"date":71,"type":37},"2019-06-04",{"date":73,"type":20},"2026-09-06",{"name":75,"class":44},"Centre Hospitalier Universitaire, Amiens",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":45},"100620176","phase-4-workflow-optimization-during-pulse-field-ablation-for-atrial-fibrillation-100620176","NCT07354217","Workflow Optimization During Pulse Field Ablation for Atrial Fibrillation","PFA_workflow","Inclusion Criteria:\n\n1. Patients with paroxysmal or persistent AF and are scheduled to undergo PVI.\n2. Patients who can understand the study aims and protocol and are willing to follow the protocol for one year.\n\nExclusion Criteria:\n\n1. Informed consent could not be obtained\n2. Known allergy to study drug lidocaine.\n3. Presence of thrombus in the LA or LA appendage\n4. Underlying significant pulmonary disease, such as asthma or COPD needing long term maintenance therapy or documented interstitial lung disease",{"count":19,"type":20},[85],"PHASE4","To evaluate the efficacy and safety of intravenous lidocaine in reducing diaphragmatic contraction and suppressing the cough reflex during pulsed field ablation procedures.",[88,29],"Pulsed Field Ablation",[90,91,92,93],"Pulmonary Vein Isolation","LIDOCAINE","Pulse Field Ablation","cough suppression","NOT_YET_RECRUITING","2026-04-16",{"date":97,"type":37},"2026-04-20",{"date":99,"type":20},"2026-06-01",{"date":101,"type":20},"2030-12-31",{"name":103,"class":44},"National Taiwan University Hospital",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":111,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":45},"100612024","ketamine-lidocaine-versus-ketamine-fentanyl-for-induction-of-anesthesia-in-patients-with-left-ventricular-systolic-dysfunction-undergoing-elective-coronary-artery-bypass-100612024","NCT07248202","Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass","A Comparison Between the Effect of Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia on Cerebral Perfusion Guided by Near Infra-red Spectroscopy in Patients With Coronary Artery Disease and Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass Graft Surgery: (A Randomized Controlled Study)","Inclusion Criteria:\n\n* patients with coronary artery disease\n* with moderate to severe left ventricular dysfunction (ejection fraction \\\u003C 40%),\n* scheduled for elective CABG surgery\n\nExclusion Criteria:\n\n* associated chronic stroke, TIA , carotid occlusive disease( due to abnormal vasomotor activity), patients with known neurological impairment (cerebral infarction , dementia ), significant carotid artery stenosis ,\n* valvular heart disease,\n* persistent arrhythmias,\n* congestive cardiac failure,\n* on mechanical ventilation,\n* intra-aortic balloon pump,\n* emergency surgery,\n* and those with known allergy to any of the study's drugs,\n* severe systemic non-cardiac disease and\n* patients with baseline NIRS reading \\\u003C 60%\n* Patients with dementia or visual or auditory impairment","21 Years",{"count":113,"type":20},40,[23],"This study compares ketamine\u002Ffentanyl versus ketamine\u002Flidocaine in term of their impact on cerebral perfusion during CABG. No prior data address these effects, and the goal is to identify the induction regimen that better preserves cerebral oxygenation.",[117,118,119,120,121,122,29],"Coronary Artery Disease (CAD)","Left Ventricular (LV) Systolic Dysfunction","Induction Anesthesia","Coronary Bypass Graft Surgery","Ketamine","Fentanyl","2026-03-15",{"date":125,"type":37},"2026-03-17",{"date":127,"type":37},"2025-12-01",{"date":129,"type":20},"2026-07",{"name":43,"class":44},{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":21,"phases":140,"briefSummary":141,"conditions":142,"keywords":147,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":4},"100621771","phase-4-minimal-effective-volume-90-for-double-injection-costoclavicular-block-100621771","NCT07374952","Minimal Effective Volume 90% for Double-injection Costoclavicular Block","Minimum Effective Volume of Lidocaine for Double-Injection Ultrasound-Guided Costoclavicular Block","Inclusion Criteria:\n\n* Age between 18 and 70 years\n* American Society of Anesthesiologists classification 1-3\n* Body mass index between 20 and 30\n\nExclusion Criteria:\n\n* Adults who are unable to give their own consent\n* Pre-existing neuropathy (assessed by history and physical examination)\n* Coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. platelets≤ 100, International Normalized Ratio≥ 1.4 or partial prothrombin time ≥ 50)\n* Renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. creatinine≥ 100)\n* Hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. transaminases≥ 100)\n* Allergy to LA\n* Pregnancy\n* Prior surgery in the infraclavicular region\n* Chronic pain syndromes requiring opioid intake at home","70 Years",{"count":19,"type":20},[85],"In 2020, a trial demonstrated that a 2-injection technique constitutes the optimal method for the costoclavicular block.\n\nThis study aims to determine the minimum amount of medication required to achieve a successful double-injection costoclavicular nerve.\n\nBlock dose assignment will be done using an up-and-down sequential method, called the Biased Coin Design (BCD).\n\nThe double-injection technique for US-guided costoclavicular block consists in depositing two thirds of the LA volume in the deep compartment (to anesthetize the posterior and medial cords), and one third of the injectate in the superficial compartment (to anesthetize the lateral cord).\n\nThe ED90 will be calculated using isotonic regression with a 95% confidence interval derived by bootstrapping.",[143,29,144,145,146],"Brachial Plexus Blocks","Nerve Block","Dose Finding Study","Costoclavicular Block",[148,149,150,151,65],"costoclavicular block","double injection technique","dose finding","nerve block","2026-02-18",{"date":154,"type":37},"2026-02-20",{"date":156,"type":20},"2026-02-01",{"date":158,"type":20},"2026-12-31",{"name":160,"class":44},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":168,"sex":16,"minAge":169,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":21,"phases":172,"briefSummary":173,"conditions":174,"keywords":176,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":183,"leadSponsor":185,"locationsCount":45},"100618152","intravenous-lidocaine-infusion-versus-intravenous-dexmedetomidine-infusion-during-sleeve-gastrectomy-100618152","NCT07327905","Intravenous Lidocaine Infusion Versus Intravenous Dexmedetomidine Infusion During Sleeve Gastrectomy","Intravenous Lidocaine Infusion Versus Intravenous Dexmedetomidine Infusion During Laparoscopic Sleeve Gastrectomy : the Effect on Recovery Outcomes Variables","Inclusion Criteria:\n\n* Age: 20-50 years, both sexes.\n* American Standards Association (ASA) physical status class II to III.\n* Body mass index (BMI) 35-50 kg m-².\n\nExclusion Criteria:\n\n* Cardiac conduction disorders.\n* Cardiomyopathy.\n* Chronic opioid use.\n* Allergy to the studied medications.\n* Pregnancy and breastfeeding.",true,"20 Years","50 Years",{"count":113,"type":20},[23],"Although laparoscopic (LAP) bariatric surgery is minimally invasive. Following any laparoscopic procedure, patients typically experience the peak of postoperative pain within the first 24 hours. This intense pain gradually subsides, with significant relief usually occurring by the 2nd or 3rd postoperative day. The initial peak and subsequent decline in pain intensity highlight the importance of effective early pain management strategies to ensure patient comfort and recovery during this critical period. Inadequate management of postoperative pain can result in serious complications. Lidocaine is increasingly recognised as a vital adjunct in managing perioperative pain. Its efficacy extends beyond traditional local anaesthetic applications, as it also demonstrates analgesic, anti-hyperalgesic, and anti-inflammatory properties. Dexmedetomidine is a highly selective alpha-2 adrenergic agonist with hypnotic, sedative, anxiolytic, sympatholytic, and analgesic effects, while causing minimal respiratory depression",[175,29,27],"Bariatric Surgery",[65,177,178],"dexmedetomidine","bariatric","2025-12-26",{"date":181,"type":37},"2026-01-08",{"date":179,"type":37},{"date":184,"type":20},"2026-11-01",{"name":186,"class":44},"Alexandria University",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":16,"minAge":194,"maxAge":4,"enrollmentInfo":195,"targetDuration":4,"studyType":21,"phases":197,"briefSummary":198,"conditions":199,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":45},"100601305","intraoperative-infusion-of-either-lidocaine-or-dexmedetomidine-on-regional-cerebral-oxygen-saturation-and-postoperative-delirium-in-elderly-patients-undergoing-abdominal-surgeries-100601305","NCT07108764","Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries","Effect of Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries","Inclusion Criteria:\n\n* Age ≥ 65years old.\n* Both sexes.\n* Physical status classification of II - III according to the American Society of Anesthesiologists (ASA).\n* Undergo elective non-cardiac surgeries.\n\nExclusion Criteria:\n\n* History of mental illness, neurological illness, or scoring less than 8 using the abbreviated mental test (AMT) before operation.\n* Severe hearing or visual impairment that may interfere with communication.\n* Severe renal or hepatic dysfunction.\n* Patients on central nervous system (CNS) medications (antipsychotics, anticonvulsants, antiparkinsonian, antidepressants).\n* Contraindications to lidocaine or dexmedetomidine \\[e.g., allergy, severe bradycardia, atrioventricular (AV) block\\].","65 Years",{"count":196,"type":20},100,[23],"This study aims to compare the effect of intraoperative infusion of either lidocaine or dexmedetomidine on the incidence of postoperative delirium (POD) in elderly patients undergoing major surgeries. It also aims to evaluate the impact of both medications on intraoperative regional cerebral oxygen saturation (rSO₂).",[200,29,27,201,202,203,204],"Intraoperative Infusion","Cerebral Oxygen Saturation","Postoperative Delirium","Elderly Patients","Abdominal Surgeries","2025-07-31",{"date":207,"type":37},"2025-08-07",{"date":209,"type":37},"2025-04-17",{"date":211,"type":20},"2027-04-01",{"name":213,"class":44},"Tanta University",{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":221,"minAge":17,"maxAge":194,"enrollmentInfo":222,"targetDuration":4,"studyType":21,"phases":224,"briefSummary":225,"conditions":226,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":45},"100597736","sevoflurane-with-or-without-intravenous-lidocaine-infusion-versus-propofol-anesthesia-on-intracranial-pressure-and-cerebral-oxygenation-during-laparoscopic-hysterectomy-100597736","NCT07062367","Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy","Effect of Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy: A Randomized Controlled Study","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* American Society of Anesthesiologists (ASA) physical status I and Ⅱ.\n* Body mass index (BMI) ≤35.\n* Females scheduled for laparoscopic hysterectomy.\n\nExclusion Criteria:\n\n* Patients' refusal to participate in the study.\n* Hypersensitivity and allergy to drugs of the study.\n* Contraindication for optic nerve sheath diameter assessment. E.g., patient with pre-existing ophthalmic diseases, a history of ophthalmic surgery\n* Any central nervous system or cardiovascular disease, severe hepatic or renal impairment\n* Intraoperative circumstances, such as inability to perform optic nerve sheath diameter or conversion to open surgery\n* If peak inspiratory pressure (PIP) exceeds 35.","FEMALE",{"count":223,"type":20},90,[23],"This study will be conducted to evaluate the effects of different anesthetic modalities \\[sevoflurane with or without intraoperative lidocaine infusion and Propofol total intravenous anesthesia (TIVA)\\] on intracranial pressure (ICP) and cerebral oxygenation assessed by non-invasive methods during laparoscopic hysterectomy (LH).",[227,29,228,229,230,231],"Sevoflurane","Propofol","Intracranial Pressure","Cerebral Oxygenation","Laparoscopic Hysterectomy","2025-07-02",{"date":234,"type":37},"2025-07-14",{"date":236,"type":37},"2025-02-01",{"date":238,"type":20},"2027-02-01",{"name":213,"class":44},{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":16,"minAge":111,"maxAge":247,"enrollmentInfo":248,"targetDuration":4,"studyType":21,"phases":250,"briefSummary":251,"conditions":252,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":45},"100590337","phase-4-lidocaine-infusion-versus-magnesium-infusion-in-decreasing-fentanyl-requirements-in-endoscopic-sinus-surgeries-100590337","NCT06966102","Lidocaine Infusion Versus Magnesium Infusion in Decreasing Fentanyl Requirements in Endoscopic Sinus Surgeries","Evaluating the Effect of Lidocaine Infusion Versus Magnesium Sulfate Infusion on Decreasing Total Fentanyl Requirements in Patients Undergoing Functional Endoscopic Sinus Surgeries: a Randomized Controlled Study","Inclusion Criteria:\n\n* Age from 21 to 60 years.\n* Both genders.\n* American society of Anesthesiologist (ASA) physical status I-II\n* Scheduled for functional endoscopic sinus surgery under general anesthesia.\n\nExclusion Criteria:\n\n* Patients with prolonged QT interval.\n* Patients with renal disease.\n* Patients with a history of allergy to lidocaine or magnesium sulfate.\n* American Society of Anesthesiologists class higher than II.\n* Patient refusal","60 Years",{"count":249,"type":20},156,[85],"Enhanced recovery after ear, nose and throat surgery is based on multimodal and multidisciplinary perioperative interventions to decrease postoperative pain. Functional endoscopic sinus surgery is a surgical management for chronic rhinosinusitis. Although a common procedure, there is a lack of knowledge about perioperative pain and specific pain management after such a procedure. Most of recommendations given in guidelines for postoperative pain management in nasal surgery and sinus surgery are subsumed under head and neck surgery. Head and neck surgery is a wide field covering widely variable surgical procedures. So, postoperative pain management guidelines may not meet the requirements for pain management during and after endoscopic sinus surgery.\n\nVarious medications have been used to improve the surgical field and postoperative pain including intravenous clonidine, dexmedetomidine, lidocaine, and magnesium.\n\nLidocaine has been used considering its analgesic, immuno-modulating, and anti-inflammatory properties. The opioid sparing effect of lidocaine is supported by a high level of evidence. The effectiveness of lidocaine infusion in obtaining reduction of postoperative pain, gastrointestinal recovery time, postoperative nausea and vomiting, and shortening the hospital length of stay, was demonstrated principally in major gastro-intestinal surgery.\n\nMagnesium sulfate is a good option in multimodal analgesia, as it stabilizes the cell membrane and intracytoplasmic organelles by mediating the activation of Na+-K+ ATPase and Ca++ ATPase enzymes, which have an important role in transmembrane ion exchange during the depolarization and repolarization phases. Moreover, magnesium inhibits the release of norepinephrine by blocking the N-type Ca++ channels at nerve endings.\n\nMany studies were designed to prove the role of the analgesic effect of lidocaine and magnesium infusion. However, this is the first randomized controlled study to assess the effect of lidocaine infusion versus magnesium sulphate infusion on decreasing total fentanyl requirements in patients undergoing functional endoscopic sinus surgery.\n\nThis randomized controlled trial was designed to compare the efficacy of lidocaine hydrochloride infusion versus magnesium sulphate infusion in controlling perioperative pain in patients undergoing functional endoscopic sinus surgery.",[253,254,29,28,255],"Enhanced Recovery","Functional Endoscopic Sinus Surgery","Perioperative Pain","2025-05-03",{"date":258,"type":37},"2025-05-11",{"date":260,"type":20},"2025-05-10",{"date":262,"type":20},"2025-07-30",{"name":43,"class":44},{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":194,"enrollmentInfo":271,"targetDuration":4,"studyType":21,"phases":273,"briefSummary":274,"conditions":275,"keywords":277,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":4},"100589276","intravenous-lidocaine-plus-intratracheal-dexmedetomidine-on-postoperative-sore-throat-100589276","NCT06952309","Intravenous Lidocaine Plus Intratracheal Dexmedetomidine on Postoperative Sore Throat","Effect of Intravenous Lidocaine Combined With Intratracheal Dexmedetomidine on Postoperative Throat Pain in Patients Undergoing Thyroid Cancer Surgery","Inclusion Criteria:\n\n* Thyroid cancer surgery with ASA grades I-II\n* Aged 18-65 years\n* The patient's communication is normal and they have a certain learning ability\n\nExclusion Criteria:\n\n* Severe respiratory and circulatory system diseases\n* There was bradycardia (HR \\\u003C 60 beats\u002Fminute) or atrioventricular block before the operation\n* Nervous system disease\n* Mental and psychological disorders\n* Abnormal liver and kidney functions\n* Pregnant and lactating women",{"count":272,"type":20},144,[23],"Objective: The present study was to investigate the effect of intravenous lidocaine combined with intratracheal dexmedetomidine on postoperative sore throat in patients undergoing thyroid cancer surgery.\n\nMethods: Investigators enrolled 144 patients with American Society of Anesthesiologists (ASA) physical status I and II, aged 18-65 years, and scheduled for elective undergoing thyroid cancer surgery with general anesthesia. The participants were randomly assigned into four groups(n=36 each group): Group L received lidocaine 1.5 mg\u002Fkg was injected intravenously 3 min before endotracheal intubation and tracheal spray with 0.8% ropivacaine 40 mg (5 mL) for surface anesthesia. Group D received equal volume normal saline was injected intravenously 3 min before tracheal intubation and tracheal spray with dexmedetomidine (1 μg\u002Fkg) mixed with 0.8% ropivacaine 40 mg (5 mL). Group LD received lidocaine 1.5 mg\u002Fkg was injected intravenously 3 min before endotracheal intubation and tracheal spray with dexmedetomidine (1 μg\u002Fkg) mixed with 0.8% ropivacaine 40 mg (5 mL). Group C received equal volume normal saline was injected intravenously 3 min before tracheal intubation and tracheal spray with 0.8% ropivacaine 40 mg (5 mL) for surface anesthesia.The incidence and severity of postoperative sore throat were recorded in four groups at 1 h, 2 h, 6 h, 24 h and 48 h after operation.",[27,29,276],"Sore Throat",[177,65,278,279],"thyroid surgery","sore throat","2025-04-28",{"date":282,"type":37},"2025-04-30",{"date":284,"type":20},"2025-04-25",{"date":286,"type":20},"2025-09-25",{"name":288,"class":44},"Anqing Municipal Hospital",{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":221,"minAge":17,"maxAge":296,"enrollmentInfo":297,"targetDuration":4,"studyType":21,"phases":298,"briefSummary":299,"conditions":300,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":309,"leadSponsor":310,"locationsCount":45},"100586074","dexmedetomidine-versus-lidocaine-infusions-as-adjuvants-to-general-anesthesia-for-chronic-pain-management-after-mastectomy-100586074","NCT06910644","Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy","Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age from 18 to 75 years.\n* American Society of Anesthesiologists (ASA) physical status II.\n* Scheduled for mastectomy with axillary dissection (either modified radical mastectomy with or without latissimus dorsi flap or conservative breast surgery) due to breast cancer.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Known allergy to any of the study drugs.\n* Those with hepatic or renal insufficiency.\n* Patients who are running regularly on B blockers.\n* α2 adrenergic agonists and sedatives.\n* Psychoactive medications.","75 Years",{"count":223,"type":20},[23],"This study aims to compare dexmedetomidine and lidocaine infusions as adjuvants to general anesthesia for chronic pain management after mastectomy.",[27,29,301,302,32,303,304],"Infusion","Adjuvants","Chronic Pain","Mastectomy","2025-04-05",{"date":307,"type":37},"2025-04-08",{"date":305,"type":37},{"date":127,"type":20},{"name":43,"class":44},{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":318,"targetDuration":4,"studyType":21,"phases":320,"briefSummary":321,"conditions":322,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":4},"100579769","phase-4-perioperative-lidocaine-infusions-for-the-management-of-pain-from-burn-injury-100579769","NCT06828601","Perioperative Lidocaine Infusions for the Management of Pain From Burn Injury","Perioperative Lidocaine Infusions for the Management of Pain From Burn Injury: A Pilot Study to Investigate Analgesic and Opioid Sparing Effects","Inclusion Criteria:\n\n* Acute burn patients\n* 18 years or older\n* \\\u003C20% Total Body Surface Area\n* Wound debridement surgery scheduled at Harborview Medical Center\n\nExclusion Criteria:\n\n* History of polysubstance use\n* Chronic opioid use (MED\\>40mg for more than 6 weeks)\n* Cases where the known clinical standard care would be to keep patient intubated postoperatively\n* Cases where the known clinical standard care would avoid IV Lidocaine infusion\n* Allergy to amide local anesthetics\n* Any elevated risk for local anesthetic systemic toxicity as determined by the study team\n* Cardiac arrythmias or cardiovascular instability (e.g. shock)\n* Severe renal or hepatic impairment\n* Pregnancy\n* Local anesthesia will be given by another route (e.g. nerve block)\n* Prisoners\n* Non-English Speaking\u002Freading",{"count":319,"type":20},20,[85],"The purpose of this study is to find out if IV lidocaine infusion decreases the need of opioids, improves pain management, and reduces the risks of developing complications from prolonged opioid use in burn injury participants undergoing wound debridement in the operating room.\n\nParticipants will:\n\n* be randomized to receive either an IV Lidocaine treatment or an IV Saline Placebo during their surgery. The IV treatment continues for 48 hours after surgery.\n* be asked about their pain and how they're feeling at 4 timepoints during the 48 hours.\n* be asked about their pain 2 weeks after surgery.\n\nThe participant and medical care providers will both be blinded to what IV treatment is being received.\n\nResearchers will compare the 2 groups to see if IV Lidocaine helps decrease the need of opioids, improves pain management, and reduces the risks of developing complications from prolonged opioid use (this includes opioid tolerance, opioid dependence, and opioid induced hyper-sensitivity to pain).",[323,324,29],"Pain Management","Burn Injury","2025-03-31",{"date":327,"type":37},"2025-04-04",{"date":329,"type":20},"2025-04",{"date":331,"type":20},"2026-01",{"name":333,"class":44},"University of Washington",{"id":335,"slug":336,"hasResults":11,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":4,"eligibilityCriteria":340,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":194,"enrollmentInfo":341,"targetDuration":4,"studyType":21,"phases":342,"briefSummary":343,"conditions":344,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":350,"leadSponsor":352,"locationsCount":45},"100581319","lidocaine-and-dexmedetomidine-infusions-for-intraoperative-bleeding-in-functional-endoscopic-sinus-surgery-100581319","NCT06848764","Lidocaine and Dexmedetomidine Infusions for Intraoperative Bleeding in Functional Endoscopic Sinus Surgery","A Randomized Double-Blind Trial Comparing Lidocaine and Dexmedetomidine Infusions for Intraoperative Bleeding in Patients Undergoing Functional Endoscopic Sinus Surgery","Inclusion Criteria:\n\n* Age from 18 to 65 years old.\n* American Society of Anesthesiologists (ASA) physical status I - II.\n* Scheduled for elective functional endoscopic sinus surgery.\n\nExclusion Criteria:\n\n* Diabetes mellitus.\n* Coagulation disorders.\n* Kidney and liver dysfunction.\n* Cerebrovascular disease.\n* Cardiovascular problems.\n* High blood pressure.\n* Asthma.\n* Chronic obstructive pulmonary disease (COPD).\n* End organ damage.\n* Psychosis.\n* Taking antipsychotic drugs.\n* Allergy to study drugs.\n* Substance abuse.\n* Taking beta blockers.\n* Heart rate of \\\u003C 55 beat\u002Fminute.",{"count":113,"type":20},[23],"This work aims to compare lidocaine and dexmedetomidine infusions for intraoperative bleeding in patients undergoing functional endoscopic sinus surgery.",[29,27,301,345,254],"Intraoperative Bleeding","2025-03-01",{"date":348,"type":37},"2025-03-05",{"date":346,"type":37},{"date":351,"type":20},"2025-09-01",{"name":353,"class":44},"Ain Shams University",{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":361,"targetDuration":4,"studyType":21,"phases":363,"briefSummary":364,"conditions":365,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":371,"leadSponsor":373,"locationsCount":45},"100580455","lidocaine-and-dexmedetomidine-infusion-and-their-combination-on-perioperative-pain-in-patients-undergoing-video-assisted-thoracoscopic-surgery-100580455","NCT06837519","Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery","A Randomized Double-Blind Trial Comparing Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery","Inclusion Criteria:\n\n* Age ≥18 years old.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status of I, II.\n* Patients undergoing video-assisted thoracoscopic surgery (VATS) under general anesthesia.\n\nExclusion Criteria:\n\n* Hypersensitivity to any of the used drugs.\n* Coagulation disorder.\n* Body mass index \\>35 kg\u002Fm2.\n* History of chronic pain requiring daily opioids\u002Fsteroids\u002Fclonidine\u002Fother α2 agonist\u002Fanalgesics or any drugs acting on the central nervous system during the previous 2 weeks, and drug\u002Falcohol abuse.\n* Contraindication to the use of local anesthetics.\n* Cardiovascular disease.\n* Severe respiratory, renal or hepatic impairment.\n* Insulin-dependent diabetes mellitus.\n* Central nervous system or psychiatric disease.",{"count":362,"type":20},75,[23],"This study aims to compare lidocaine and dexmedetomidine infusion and their combination on perioperative pain in patients undergoing video-assisted thoracoscopic surgery.",[29,27,301,255,366],"Video-Assisted Thoracoscopic Surgery","2025-02-20",{"date":369,"type":37},"2025-02-21",{"date":367,"type":37},{"date":372,"type":20},"2025-08-01",{"name":353,"class":44}]