[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"life-style-healthy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:life-style-healthy":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,49,72,98,127,153],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100639143","digital-engagement-for-lifelong-health-100639143",false,"NCT07612852","Digital Engagement for Lifelong Health","Digital Engagement for Lifelong Prevention and Health Improvement","DELPHI","Inclusion Criteria:\n\n* Apparent good general health status, confirmed by medical history and initial self-assessment.\n* Ability to understand the study information and provide informed consent.\n* Availability and motivation to participate for the entire duration of the study (12 months).\n* Access to a smartphone compatible with the DELPHI application.\n* Willingness to wear the wearable devices for continuous monitoring of physiological parameters.\n* Basic familiarity with mobile applications or willingness to receive training on their use.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Presence of severe chronic diseases in active phase (e.g., oncological, cardiovascular, or neurological diseases).\n* Acute or unstable conditions that could compromise participation in the protocol.\n* Current pregnancy.\n* Diagnosed major cognitive or psychiatric disorders that hinder understanding of or adherence to the protocol.\n* Current use of medications that significantly affect the parameters being monitored (e.g., psychotropic drugs, beta-blockers).\n* Simultaneous participation in other clinical studies.\n* Logistical difficulties that prevent frequent interaction with the platform (e.g., lack of connection, unwillingness to attend periodic follow-ups).",true,"ALL","18 Years","65 Years",{"count":22,"type":23},200,"ESTIMATED","INTERVENTIONAL",[26],"NA","The DELPHI project (Digital Engagement for Lifelong Prevention and Health Improvement) aims to develop, implement, and validate an advanced digital platform for promoting well-being and personalized prevention of chronic non-communicable diseases in healthy adults. By integrating wearable sensors, artificial intelligence, federated learning, and the Human Digital Twin (HDT) paradigm, the DELPHI platform is designed to collect, analyze, and interpret multidimensional data in order to deliver dynamic and personalized recommendations for healthy lifestyles.\n\nThe study adopts a multicenter, randomized controlled pilot design, with a maximum duration of 12 months per participant. A total of 200 healthy adults aged 18-65 will be recruited in Southern Italy (Sicily, Campania, and Basilicata) and randomly assigned to either: (1) an experimental group using the full DELPHI platform, including personalized recommendations, adaptive content, and continuous feedback; or (2) a control group using a basic version limited to passive monitoring.\n\nAs a non-clinical primary prevention pilot study, DELPHI aims to assess the operational feasibility, usability, and acceptability of the platform in real-world settings, while also exploring preliminary signals of impact on health and lifestyle domains without confirmatory purposes. Secondary objectives include monitoring physiological indicators, adherence to the app and wearable devices, and evaluating the feasibility of implementing the platform in workplace environments.\n\nData collection will rely on wearable devices, digital questionnaires, and behavioral analysis, with strong safeguards for personal data protection in compliance with GDPR and advanced security approaches such as federated learning and encryption.\n\nSpecific subgroups, including workers from the Fondazione Don Carlo Gnocchi (FDG) as well as university staff and students, will be involved in targeted assessments related to mental well-being and distress. In addition, workers from the FDG will test a virtual reality module designed to evaluate biomechanical overload risks during manual handling activities in simulated environments. These additional physiological and virtual reality components are exploratory and non-diagnostic.\n\nOverall, DELPHI seeks to provide a solid foundation for the adoption of predictive and personalized models in digital health, contributing to the development of a sustainable and accessible prevention ecosystem, particularly in Southern Italy.",[29,30,31],"Life Style, Healthy","Risk Reduction","Health Promotion",[33,34,35],"health","digitalization","prevention","RECRUITING","2026-05-25",{"date":39,"type":40},"2026-05-29","ACTUAL",{"date":42,"type":40},"2026-05-04",{"date":44,"type":23},"2027-03-30",{"name":46,"class":47},"Istituto per la Ricerca e l'Innovazione Biomedica","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100571794","brain-health-on-college-campuses-100571794","NCT06724887","Brain Health on College Campuses","Inclusion Criteria:\n\n* Minimum age of 18\n* Either enrolled as a student and\u002For employed as staff\u002Ffaculty at UTD or Dallas College\n* Internet and device access\n* Must be able to hear and read over the computer\n* Fluent English speaker\n\nExclusion Criteria:\n\n* Currently or previously enrolled in The BrainHealth Project (NCT04869111)\n* Diagnosed neurodegenerative disease\n* History of stroke, concussion, or brain injury that currently hinders participant from functioning at their prior level\n* Diagnosed with autism spectrum disorder and not functioning independently","110 Years",{"count":57,"type":23},1000,[26],"Center for BrainHealth is beginning a one-year pilot with local college campuses investigating the impact of (i) brain health assessment and training tools delivered through the online BrainHealth Platform and (ii) in-person educational brain health workshops delivered to college students and faculty\u002Fstaff, with the overarching goal to better understand how to promote brain-healthier campuses (i.e., reflecting generally positive function across cognitive, social, emotional, and lifestyle domains). This initial study is intended to be a one-year pilot, with findings informing feasibility and efficacy as well as future, more extended and expanded study informing translation to other colleges\u002Funiversities.",[61,29],"Health Behavior","2026-01-30",{"date":64,"type":40},"2026-02-03",{"date":66,"type":40},"2025-01-13",{"date":68,"type":23},"2027-12-31",{"name":70,"class":47},"The University of Texas at Dallas",2,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":17,"sex":18,"minAge":79,"maxAge":20,"enrollmentInfo":80,"targetDuration":4,"studyType":24,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":48},"100498776","lipo-teen-the-lifestyle-in-pregnancy-and-offspring-teenagers-100498776","NCT05774652","LiPO Teen (the Lifestyle in Pregnancy and Offspring Teenagers","LiPO Teen (the Lifestyle in Pregnancy and Offspring Teenagers): Identification of Modifiable Risk Factors for Childhood Obesity - a Follow-up of a Randomized Controlled Trial","Inclusion Criteria:\n\n* Mothers in the initial LiP study selected at the baseline study in 2007-2010\n* Teenagers of mothers in the initial LiP study\n\nExclusion Criteria:\n\n• None","13 Years",{"count":81,"type":23},301,[26],"The study is a follow-up of a Randomized Controlled Trial (RCT) performed in 2007-10 - the \"Lifestyle in Pregnancy\" LiP study.\n\nThe LiP study included 360 pregnant women with BMI ≥30 kg\u002Fm2 from Odense University Hospital and Aarhus University Hospital. The women were randomized to intervention with low-calorie diet and physical activity from gestational age 10-14 in pregnancy and until delivery - or to a standard care control group. The objective of the LiPO-Teen project is to perform a clinical follow-up study of the eligible 301 mothers who completed the trial until delivery with a liveborn child, and their 14 year-old offspring. The overall ambition is to understand whether lifestyle intervention in pregnancy prevents obesity and its complications across generations, with a specific focus on modifiable factors.",[85,29,86,87,88],"Obesity","Follow-up","Gestational Weight Gain","Body Weight","2025-11-16",{"date":91,"type":40},"2025-11-19",{"date":93,"type":40},"2023-10-26",{"date":95,"type":23},"2026-03-01",{"name":97,"class":47},"Odense University Hospital",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":18,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":24,"phases":110,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":48},"100591874","lifestyle-for-the-brain-health---nutrition-and-exercise-training-intervention-100591874","NCT06986096","Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention","Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention, LIBRA-NET","LIBRA-NET","Inclusion Criteria:\n\n* Non-smokers\n* Signed informed consent\n* Presence of subjective or mild cognitive impairment (SCI\u002FaMCI)\n* Elevated levels of selected biomarkers confirming the presence of a pathological process characteristic of Alzheimer's disease\n* Absence of any psychological, sociological, or geographical factors that could jeopardize participation in the project.\n\nExclusion Criteria:\n\n* Presence of severe cardiovascular, liver, or kidney diseases; advanced or poorly controlled diabetes mellitus (HbA1c \\>7%), treated with insulin or incretin analogs; cancer or any other severe disease as assessed by the responsible physician. A history of cancer treated with chemotherapy or radiotherapy if within less than 5 years post-treatment.\n* Lack of cooperation, inflexible schedule, or problematic transportation.\n* Insufficient functional capacity or presence of comorbidities that prevent participation in the training program (assessment by an internist, cardiologist, neurologist, orthopedic specialist, or other relevant specialists).\n* Presence of a pacemaker or any metal implants (contraindication for MRI examination), or allergy to local anesthetics (contraindication for muscle biopsy).\n* Smoking, alcohol dependence, or addiction to other narcotic substances.\n* Stroke or myocardial infarction within the last year.\n* Long-term treatment for psychiatric disorders - a depressive syndrome is not an exclusion criterion if it is compensated by therapy.\n* Other diseases of the musculoskeletal or nervous system that potentially interfere with the ability to exercise or cognition - such as severe arthritis, Parkinson's disease, significant essential tremor, epilepsy, etc.\n* Concurrent participation in another clinical study.\n* Therapy with cholinesterase inhibitors unless the patient is on a stable dose.","60 Years","80 Years",{"count":109,"type":23},40,[26],"Due to the increasing incidence of dementia and the lack of causal treatment, non-pharmacological interventions represent an attractive and effective therapeutic strategy of neurodegenerative diseases, such as Alzheimer's disease.\n\nThe aim of the study is to assess the impact of a supervised 9-month intervention with aerobic-strength training and nutritional counseling compared to cognitive training and stretching on the brain, cognitive and motor functions, metabolism, physical fitnes and plasma markers of neurodegenertion in older adults at increased risk of developing Alzheimer's disease.",[113,114,29,115,116],"Aging","Alzheimer Disease","Exercise","Cognitive Impairment","2025-05-22",{"date":119,"type":40},"2025-05-29",{"date":121,"type":40},"2024-09-01",{"date":123,"type":23},"2026-12",{"name":125,"class":126},"Slovak Academy of Sciences","OTHER_GOV",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":18,"minAge":134,"maxAge":135,"enrollmentInfo":136,"targetDuration":4,"studyType":24,"phases":138,"briefSummary":139,"conditions":140,"keywords":143,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":48},"100505323","bimbingamba-zerosix-third-phase-studying-communities-100505323","NCT05859867","Bimbingamba Zerosix Third Phase: Studying Communities","Bimbingamba","Inclusion Criteria:\n\n* Children aged 0-5 year of both sex resident in the two Municipalities under evaluation\n* children having date of birth between 1\u002F1\u002F2018 and 31\u002F12\u002F2022 (subjects born 5 years prior to the start of the project)\n* newborns between 01\u002F1\u002F2023 and 21\u002F6\u002F2023 residing in the two municipalities under study.\n\nExclusion Criteria:\n\n* Residence\u002Fdomicile in the municipalities under investigation, for a period of time less than 6 months following recruitment;\n* Recruitment of the child in other intervention trials of any nature.","2 Days","5 Years",{"count":137,"type":23},2000,[26],"Childhood obesity is increasing in the last years especially in developed countries, and, as well as adult obesity, is related to the development of pathologies. Unfortunately, the restoration of a normal weight condition, if the ponderal excess rose in the first years of life, seems very difficult. Despite the importance of this issue, there is a paucity of evidence demonstrating effective interventions in reducing weight over time. The observation that in developed countries childhood obesity appears with evident social and geographical gradients justifies the implementation of inter-sectoral interventions of primary prevention, to be declined at the contextual level: family and community. Nowadays, there are numerous interventions for the promotion of lifestyle in pediatric age, in particular, those aimed at primary school and adolescence. On the other hand, few interventions were directed at the 0-7 age group.\n\nTherefore, this community intervention trial involved the pediatric population (aged 0-7 years) and their families, and it is aimed at the prevention of obesity and the restoring normal weight through community interventions aimed at improving lifestyles and with them the bio-metric parameters, health and well-being outcomes and soft skills in the population aged 0-7 years.\n\nThe target population is children aged 0-7 years resident in the two municipalities (Mondovì and Savigliano), respectively selected as Intervention and Control Common. Totally, to conduct this study 2000 children, of both sex, will be enrolled (near 1000 for each of the two Municipalities).",[85,141,142,29],"Childhood Obesity","Weight Loss",[141],"2024-07-31",{"date":146,"type":40},"2024-08-01",{"date":148,"type":40},"2023-04-15",{"date":150,"type":23},"2025-12-31",{"name":152,"class":47},"Azienda Ospedaliero Universitaria Maggiore della Carita",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":24,"phases":163,"briefSummary":164,"conditions":165,"keywords":175,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":48},"100417487","health-enhancing-adapted-physical-activity-program-at-mon-stade-100417487","NCT04716322","Health-Enhancing Adapted Physical Activity Program at \"Mon Stade\"","Study of the Determinants Associated With Sustained Changes in Physical Activity Behaviors, and Their Effects on the Prevention and Treatment of Chronic Diseases, in Individuals Enrolled in an Adapted Physical Activity Program","SESAME","Inclusion Criteria:\n\n* Male or female\n* 18 years of age or older\n* Speaking and understanding French\n* Affected by a chronic pathology according to a predefined list (LTI, obesity, HTA, COPD, COVID-19 with persistent symptoms)\n* Carrier of a writing APA prescription\n* Able to come to \"Mon Stade\" twice a week for their APA sessions following the 16-week health-adapted PA program;\n* Signature of the information and consent form.\n\nExclusion Criteria:\n\n\\- Women whose pregnancy is known",{"count":162,"type":23},2024,[26],"Introduction: Regular practice of exercise or physical activity (PA) is a recognized intervention as a determinant of good health acquisition, maintenance, or recovery for a large number of chronic pathologies. Nevertheless, few studies have evaluated adherence to an initial health-adapted PA (APA) program, and persistence of active behavior over the time in individuals with a chronic disease.\n\nThe aim of the study is to determine the brakes and levers associated with motivation and long-term compliance. In addition, the investigators aim to evaluate the cost-effectiveness of such program in term of care consumption. Finally, the investigators complete their interest for APA prescription from practitioners agreeing to enroll their patients in the present study.\n\nMethod: The investigators perform a prospective monocentric cohort, of 2024 patients affected of a chronic disease or long-term illness (LTI), enrolled from 2021 to 2024 (4 years, 506 per year), for a 16-week APA program, and followed 5 years with an annual fitness and habits of life and care consumption evaluation.",[166,167,168,169,170,29,171,172,173,174],"Exercise Therapy","Behavior and Behavior Mechanisms","Adherence, Patient","Lifestyle, Sedentary","Life Style","Cost-Benefit Analysis","Prescriptions","Physical Activity","Adapted Physical Activity",[174,176,177,178,179,180,181,182,183,184,185,115,186,187,188,189,190,191,192,173,193,194,195,196,197,198,199],"Active Live Habits","Adherence","Aerobic Capacity","Behavior","Body Composition","Budget Impact Analysis","Cardiorespiratory Fitness","Care Consumption","Chronic Disease","DEXA scan","Health-Adapted Physical Activity","Health-Enhancing","Life-Style","Long-Term Illness","Medico-Economic","Motivation","Perceived Barriers","Physical Fitness","Prescription","Prevention","Psycho-social","Quality Of Life","Questionnaire","VO 2 measurement","2022-04-06",{"date":202,"type":40},"2022-04-07",{"date":204,"type":40},"2021-01-28",{"date":206,"type":23},"2030-12-31",{"name":208,"class":47},"Mon Stade Sports Medicine Centre"]