[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lifestyle-factors\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lifestyle-factors":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,41,72,110,137,173,210,244,271,300,321,348,375],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100581232","a-digital-lifestyle-intervention-in-primary-healthcare-to-prevent-cardiovascular-disease-100581232",false,"NCT06847633","A Digital Lifestyle Intervention in Primary Healthcare to Prevent Cardiovascular Disease","Inclusion Criteria:\n\n* Attended a Health dialogue visit to primary healthcare for patients 40-60 years old\n* Willing to change at least one lifestyle behavior regarding physical activity, diet, smoking\u002Fsnus, alcohol, sleep, or stress\n\nExclusion Criteria:\n\n* diabetes\n* heart failure\n* history of myocardial infarction\n* history of stroke\n* pregnancy","ALL","39 Years","61 Years",{"count":19,"type":20},1000,"ESTIMATED","INTERVENTIONAL",[23],"NA","Unhealthy lifestyle behaviors are well-established risk factors for cardiovascular disease (CVD) which is the leading cause of death globally and in Sweden. Digitalization offers new and better possibilities for healthcare to fulfil their responsibility to support healthier lifestyles, however, to ensure scalability and sustained implementation of digital tools within healthcare, digital interventions need to be systematically maintained and delivered by the primary healthcare. The aim of this project is to evaluate whether a digital lifestyle intervention, developed within Swedish primary healthcare, can improve clinically important cardiovascular health outcomes and lifestyle behaviors. In this multi-center randomized controlled trial patients, 40-60 years, in Swedish primary healthcare will be recruited and randomized to the control or intervention group. All participants will receive standard care consisting of one structured health dialogue focused on lifestyle habits. The intervention group will also receive support through the digital lifestyle intervention for creating healthy habits regarding diet, physical activity, alcohol consumption, and tobacco usage. The primary outcome is LDL-cholesterol at 6 months post-randomization. Secondary outcomes 6 months post-randomization are HDL-, total cholesterol, fasting blood glucose, triglycerides, non-HDL, blood pressure, weight, height, BMI, waist circumference, cardiovascular risk evaluation (SCORE2), dietary intake, physical activity, sleep, stress, alcohol consumption, tobacco use, and health-related quality of life.",[26,27],"Cardiovascular Diseases","Lifestyle Factors","RECRUITING","2026-06-06",{"date":31,"type":32},"2026-06-09","ACTUAL",{"date":34,"type":32},"2025-03-03",{"date":36,"type":20},"2027-12",{"name":38,"class":39},"Karolinska Institutet","OTHER",6,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":60,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100471142","determining-the-utility-of-a-behavioral-intervention-in-chronic-migraine-100471142","NCT05415020","Determining the Utility of a Behavioral Intervention in Chronic Migraine","Feasibility, Acceptability, and Pilot Testing of a Behavioral Intervention for Chronic Migraine","RLB","Inclusion Criteria:\n\n* have chronic migraine for a minimum of 1-year\n* aged 18 years and older\n\nExclusion Criteria:\n\n* other headache disorders including secondary headache disorders\n* children younger than 18 years old\n* current pregnancy","18 Years",{"count":51,"type":20},60,[23],"This proposal will involve a pilot study to evaluate the feasibility, acceptability, and outcomes of a lifestyle behavior protocol in managing chronic migraine. Additionally, the proposal will investigate biomolecules that are uniquely involved in chronic migraine patients who respond to the protocol. Successful completion of this proposal will inform the design of a future full-scale behavioral clinical trial to control chronic migraine.",[55,56,57,58,27,59],"Migraine","Headache","Migraine Disorders","Chronic Migraine","Headache Disorders",[57,56,61],"Lifestyle","2026-06-04",{"date":64,"type":32},"2026-06-08",{"date":66,"type":32},"2022-06-29",{"date":68,"type":20},"2027-07-31",{"name":70,"class":39},"Mayo Clinic",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":15,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":85,"conditions":86,"keywords":94,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":71},"100479368","reducing-blood-pressure-in-mid-life-adult-binge-drinkers-100479368","NCT05522075","Reducing Blood Pressure in Mid-life Adult Binge Drinkers","Reducing Blood Pressure in Mid-life Adult Binge Drinkers: the Role of Microvascular Function and Sympathetic Activity","Inclusion Criteria:\n\n* Men and women (50-64 years of age) who do not drink alcohol, who drink at moderate levels, or who binge drink\n* Female subjects will be postmenopausal (i.e., cessation of menses for ≥1 yr).\n* Subjects who can speak and understand English.\n\nExclusion Criteria:\n\n* a history of diabetes, cardiovascular disease, liver, or renal disease\n* current or history of smoking and illicit drug use\n* blood pressure ≥160\u002F100 mm Hg\n* other known traditional cardiovascular disease risks: obesity (BMI≥35 kg\u002Fm2), or hyperlipidemia (total cholesterol\\>230 mg\u002Fdl and\u002For LDL cholesterol\\>160 mg\u002Fdl)\n* active infection (in the past 2 months)\n* a history of seizures, cancer, or inflammatory disease (i.e., gout or rheumatoid)\n* unstable body weight (\\>5% change during the past 6 months)\n* regular aerobic exercise training (i.e., they engage in 30 min of structured aerobic exercise at least 3 times per week)\n* current use of hormone replacement therapy (i.e., estrogen, progesterone, and testosterone)",true,"50 Years","64 Years",{"count":83,"type":20},55,[23],"This study has two phases:\n\nPhase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers\u002Fmoderate drinkers.\n\nPhase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers",[87,88,89,90,91,27,92,93],"Alcohol Drinking","Binge Drinking","Blood Pressure","Alcohol Abstinence","Aging","Vasodilation","Behavioral Problem",[95,96,97,98,99,100],"Exercise training","High-intensity interval training","Midlife adults","Middle-aged","Microvascular function","Sympathetic nerve activity","2026-05-27",{"date":103,"type":32},"2026-06-01",{"date":105,"type":32},"2022-11-21",{"date":107,"type":20},"2027-04-30",{"name":109,"class":39},"The University of Texas at Arlington",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":79,"sex":15,"minAge":118,"maxAge":119,"enrollmentInfo":120,"targetDuration":122,"studyType":123,"phases":4,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":71},"100630284","genesis-project-generating-evidence-on-the-needs-of-ecuadorian-adolescents-100630284","NCT07485673","GENESIS Project: Generating Evidence on the Needs of Ecuadorian Adolescents","Generating Evidence on the Needs of Ecuadorian Adolescents","GENESIS","Inclusion Criteria:\n\n* be between 14 and 19 years old\n\nExclusion Criteria:\n\n* have any disorder or treatment that contraindicated physical activity or that demanded special assistance\n* be under some pharmacological treatment;\n* not be authorized by parents, caregivers, or legal guardians to participate in the research project\n* do not agree to take part in the research project\n* for volunteering retirement.","14 Years","19 Years",{"count":121,"type":20},1450,"5 Years","OBSERVATIONAL","Background: Adolescence is a period of intensified emotional responses and occurs when mental health disorders commonly develop since adolescents are learning how to deal with powerful emotions. Globally, 15% of adolescents experience a mental disorder like depression or anxiety. However, adolescent mental health goes beyond mental disorders. It is state of mental well-being that allows individuals to deal with stressors, recognize their abilities, develop their activities well, and participate in society, providing a holistic approach that highlights the interplay between psychological well-being and other aspects of life. Given this perspective, a Lifestyle Medicine (LM) approach based on a multi-component framework is needed for assessing adolescents' mental health. This study aims to evaluate adolescents' (aged 14-19) mental health, identify and mitigate the risks of developing any mental health disorder as well as formulate comprehensive interventions to promote and increase their emotional wellbeing. Methods: Cross-sectional and longitudinal studies will be performed. Adolescents from Quito, Ecuador will be recruited using a simple random sampling technique. The minimum sample size is 385; however, to increase the precision of the estimates, a target sample of approximately 1000 participants will be established. Main outcome measure will be mental health using social determinants of health and lifestyle medicine factors. Conclusion: This research project will evaluate adolescents' mental health through a holistic and multiapproach evaluation and interrelate social determinants of health and lifestyle medicine variables to propose and design multidisciplinary strategies and interventions to prevent and mitigate mental health outcomes in adolescents. Additionally, the results will be useful in informing public health authorities to evaluate or modify current policies",[126,127,27],"Adolescent Development","Mental Health Issue","2026-03-16",{"date":130,"type":32},"2026-03-20",{"date":132,"type":32},"2025-09-04",{"date":134,"type":20},"2030-08",{"name":136,"class":39},"Universidad de Especialidades Espiritu Santo",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":79,"sex":15,"minAge":49,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":21,"phases":148,"briefSummary":149,"conditions":150,"keywords":161,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":71},"100618258","nighttime-synchrony-of-your-nutrition-and-circadian-health-100618258","NCT07329283","Nighttime Synchrony of Your Nutrition and Circadian Health","Nighttime Synchrony of Your Nutrition and Circadian Health: The N-Sync Study","N-Sync","Inclusion Criteria:\n\n1. Age: 18-35 years old; equal numbers of men and women\n2. Body Mass Index (BMI): 18.5-24.9 kg\u002Fm2\n3. Sleep Habits: habitual self-reported average total sleep time (TST) 7-9 hours per night for prior 6 months\n\nExclusion Criteria:\n\n1. Clinically diagnosed sleep disorder or apnea hypopnea index (AHI) ≥5\n2. Evidence of significant organ system dysfunction or disease (e.g., heart disease, diabetes)\n3. Fasting plasma glucose ≥100 mg\u002FdL\n4. Major psychiatric illness (e.g., major depressive disorder)\n5. Cancer that has been in remission less than 5 years\n6. History of shift-work in prior year\n7. Weight change \\>5% of body weight over prior six months\n8. Currently following a weight-loss program\n9. Menopause\n10. Pregnant\u002Fnursing\n11. Greater than 5-day variation in menstrual cycle length month-to-month\n12. Currently smoking\n13. Alcohol intake \\>14 drinks\u002Fweek or \\>3 drinks\u002Fday.\n14. Use of prescription medications (except oral contraceptives) within one month prior to or during in-lab visits.\n15. Consumption of illegal drugs or \\>500mg per day of caffeine.","35 Years",{"count":147,"type":20},120,[23],"Sleep is an important factor for overall health. This study will see how different light exposure patterns and food intake impact a person's metabolism (how the body breaks down food) when sleeping is reduced.\n\nParticipants will attend 6 to 8 in-person visits to the study clinic, including three overnight stays. People will complete surveys and medical tests. The study will last about 4 to 6 months.",[151,152,153,27,154,155,156,157,158,159,160],"Sleep","Metabolism Changes","Circadian Rhythm","Sleep Hygiene","Sleep Hygiene, Inadequate","Sleep Deprivation","Insufficient Sleep","Circadian Misalignment","Circadian Dysregulation","Light Exposure",[151,160,162,153,163,27,154],"Metabolism","Food Intake","2026-01-20",{"date":166,"type":32},"2026-01-22",{"date":168,"type":32},"2025-12-19",{"date":170,"type":20},"2031-05-31",{"name":172,"class":39},"University of Utah",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":79,"sex":15,"minAge":49,"maxAge":4,"enrollmentInfo":179,"targetDuration":122,"studyType":123,"phases":4,"briefSummary":181,"conditions":182,"keywords":193,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":209},"100589754","apple-health-study-100589754","NCT06958523","Apple Health Study","Inclusion Criteria:\n\n* Be at least 18 years old (at least 19 years old in Alabama and Nebraska, at least 21 years old in Puerto Rico);\n* Live in the United States of America;\n* Have an iPhone;\n* Have installed Apple Research app on your iPhone;\n* Be comfortable communicating in written and spoken English;\n* Be willing and able to provide informed consent to participate in the Study.\n\nExclusion Criteria:\n\n* Share your iCloud account, iPhone, or devices that collect health data such as Apple Watch with anyone else, because it could result in sharing another person's health information with the Study, making it challenging for researchers to use your information.",{"count":180,"type":20},500000,"The Apple Health Study aims to build a diverse and inclusive group of participants to help researchers advance our understanding of how signals and information collected from apps and devices relate to health and may be used to predict, detect, monitor, and manage changes in health.\n\nTo enroll, US residents who have an iPhone can download the Apple Research app from the App Store and go through the introduction and informed consent for the Apple Health Study. This study is fully remote, and all are invited to enroll if the eligibility criteria are met.\n\nParticipants will be asked to complete tasks and surveys, using their iPhone and Apple Research app which include:\n\n* Selecting the types of data they would like to share with the study such as health and sensor data\n* Completing tasks and surveys including areas such as personal demographic information, personal medical history, family history, and social determinants of health",[183,151,184,185,186,187,91,27,188,189,190,191,192],"Mental Health","Exercise","Hormones","Metabolic Health","Hearing","Functional Capacity","Neurological Conditions","General Health","Wellbeing","Women's Health",[177,194,195,196,197,198],"Large Scale Digital Study","Digital Biomarkers","Research App","Apple Research App","iPhone","2025-07-24",{"date":201,"type":32},"2025-07-29",{"date":203,"type":32},"2025-02-12",{"date":205,"type":20},"2030-02",{"name":207,"class":208},"Apple Inc.","INDUSTRY",2,{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":15,"minAge":217,"maxAge":218,"enrollmentInfo":219,"targetDuration":4,"studyType":21,"phases":221,"briefSummary":222,"conditions":223,"keywords":229,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":71},"100596179","lifestyle-for-the-brain-health---time-restricted-eating-and-mindfulness-100596179","NCT07042087","Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness","LIBRA REMIND","Inclusion Criteria:\n\n* Age 60-80 years\n* Diagnosis of Subjective Cognitive Impairment (SCI) or Mild Cognitive Impairment (MCI)\n* mini-mental-scale (MMSE) score between 24-30\n* Positive plasma pTau217 biomarker\n* Stable dose of iAChE therapy (if applicable)\n* Ability to participate in a 9-month intervention\n\nExclusion Criteria:\n\n* Stroke or myocardial infarction within the past year\n* Decompensated internal conditions (e.g., severe heart failure, kidney failure, unstable diabetes, GLP1 agonist therapy)\n* Long-term psychiatric treatment (except well-managed depression)\n* Neurological conditions affecting mobility or cognition (e.g., Parkinson's disease, severe tremor, epilepsy)\n* Severe sensory or motor impairment preventing protocol participation\n* Active cancer treated within the past 5 years\n* Poor anticipated compliance (e.g., transport issues, time constraints, non-cooperation)\n* Concurrent participation in another clinical study\n* Unstable iAChE medication regimen\n* Substance or alcohol dependence","60 Years","80 Years",{"count":220,"type":20},48,[23],"The study aims to evaluate the effects of a 9-month intervention combining yoga-based mindfulness techniques, cognitive training, and nutritional counseling on cognitive function, plasma markers of neurodegeneration (tau protein), physical fitness, and metabolism in older adults at increased risk of developing Alzheimer's disease.",[224,91,27,225,226,227,228],"Alzheimer Disease","Cognitive Impairment","Yoga","Time Restricted Eating","Diet Modification",[230,231,232,233,234],"Alzheimer's Disease Prevention","Mindfulness-Based Intervention","Cognitive Training","Time-Restricted Eating","Dietary consultation","2025-06-19",{"date":237,"type":32},"2025-06-27",{"date":239,"type":32},"2024-11-01",{"date":241,"type":20},"2026-12",{"name":243,"class":39},"St. Anne's University Hospital Brno, Czech Republic",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":4,"enrollmentInfo":251,"targetDuration":122,"studyType":123,"phases":4,"briefSummary":253,"conditions":254,"keywords":259,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":71},"100579570","trectamu-cancer-prevention-registry-and-repository-100579570","NCT06826014","TREC@TAMU Cancer Prevention Registry and Repository","Texas Regional Excellence in Cancer (TREC) @Texas A&M University Cancer Prevention Registry and Repository","Inclusion Criteria:\n\n* 18 years of age and older, and,\n* People participating in the Cancer Prevention and Research Institute of Texas (CPRIT) A coordinated cancer screening research program in Bryan and Navasota Family Medicine Clinics and,\n* People with COPD, liver disease, cervical intraepithelial neoplasia (CIN) lesions, having had a colonoscopy or a low dose computed tomography (LDCT) lung scan or cervical exam in the last 12 months or scheduled for one, and,\n* Able to give and comprehend the consent process, and,\n* Able to consent to donate blood and urine samples, genetic material through buccal swabs for future research, and,\n* Able to understand that their specimens, health record, and changes in health status will be followed for a five-year period and shared in deidentified form with the research community, and,\n* All sexes and gender identities.\n\nExclusion Criteria:\n\n* Declines to participate or interact with staff\u002Fshare their medical status.\n* A diagnosis of Alzheimer's disease or related dementias in a medical record indicates a progressive, debilitating condition that impairs memory, thought processes, and functioning Individuals who are unable or unwilling to provide consent will be excluded",{"count":252,"type":20},2500,"This study collects health and genetic information to implement cancer prevention and treatment strategies.",[255,256,257,258,27],"Cancer","Genetics","Disease","Diet",[260,261],"cancer","genetics","2025-02-11",{"date":264,"type":32},"2025-02-13",{"date":266,"type":20},"2025-03",{"date":268,"type":20},"2030-11",{"name":270,"class":39},"Texas A&M University",{"id":272,"slug":273,"hasResults":11,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":4,"eligibilityCriteria":277,"healthyVolunteers":79,"sex":15,"minAge":49,"maxAge":278,"enrollmentInfo":279,"targetDuration":4,"studyType":21,"phases":281,"briefSummary":282,"conditions":283,"keywords":289,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":71},"100529981","effect-of-sleep-extension-on-ceramides-in-people-with-overweight-and-obesity-100529981","NCT06180837","Effect of Sleep Extension on Ceramides in People with Overweight and Obesity","Biomarkers of Habitual Short Sleep and Related Cardiometabolic Risk","Inclusion Criteria:\n\n1. Age: 18-45 years old; equal numbers of men and women\n2. Body mass index (BMI): 27.5-34.9 kg\u002Fm2\n3. Sleep Habits: habitual self-reported average total sleep time (TST) \\\u003C6.5 hours per night for prior 6 months\n\nExclusion Criteria:\n\n1. Clinically diagnosed sleep disorder or major psychiatric illness\n2. Evidence of significant organ dysfunction or disease (e.g., heart disease, kidney disease)\n3. Clinically diagnosed diabetes or fasting plasma glucose ≥126 mg\u002FdL or HbA1c ≥6.5%\n4. Use of prescription drugs or substances known to influence sleep or glucose metabolism, or anticoagulant medications.\n5. Cancer that has been in remission less than 5 years\n6. Pregnant\u002Fnursing, experiencing menopause or post-menopausal\n7. Shift-work: current or history of within last year\n8. Weight change: \\>10% of body weight over prior six months\n9. Current enrollment in weight loss or physical activity program like the Diabetes Prevention Program\n10. Currently smoking\n11. Alcohol intake\\>14 drinks per week or \\>3 drinks per day","45 Years",{"count":280,"type":20},70,[23],"The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity. Participants will undergo a randomized controlled trial, with sleep extension (intervention) and healthy lifestyle (control) groups. The sleep extension is designed to increase participant's time in bed by 2 hours per night. Alternatively, the control group will receive basic health information (e.g., physical activity, goal setting, and nutrition when eating out).",[27,284,285,286,154,287,151,156,288],"Overweight and Obesity","Insulin Sensitivity","Eating Habit","Type 2 Diabetes","Insufficient Sleep Syndrome",[290,291],"sleep","insulin sensitivity","2024-12-18",{"date":294,"type":32},"2024-12-20",{"date":296,"type":32},"2024-02-12",{"date":298,"type":20},"2028-01",{"name":172,"class":39},{"id":301,"slug":302,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":306,"eligibilityCriteria":307,"healthyVolunteers":79,"sex":15,"minAge":49,"maxAge":278,"enrollmentInfo":308,"targetDuration":4,"studyType":21,"phases":310,"briefSummary":311,"conditions":312,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":315,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":71},"100511760","circadian-intervention-to-improve-cardiometabolic-health-100511760","NCT05943626","Circadian Intervention to Improve Cardiometabolic Health","Timing of Circadian Synchronizers: the TOCS Study","TOCS","Inclusion Criteria:\n\n1. Age: 18-45 years old; equal numbers of men and women\n2. Body mass index (BMI): 25.0-34.9 kg\u002Fm2,\n3. Sleep Habits: habitual self-reported average total sleep time (TST) \\\u003C6.5 hours per night for prior 6 months\n\nExclusion Criteria:\n\n1. Clinically diagnosed sleep disorder or major psychiatric illness\n2. Evidence of significant organ dysfunction or disease (e.g., diagnosed diabetes, cardiovascular disease, or kidney disease)\n3. Use of prescription drugs or substances known to influence sleep or glucose metabolism\n4. Shift-work: current or history of within last year\n5. Weight change: \\>10% of body weight over prior six months\n6. Experiencing menopause or post-menopausal\n7. Current enrollment in weight loss or physical activity program like the Diabetes Prevention Program\n8. Currently pregnant or planning to become pregnant, or currently lactating.\n9. Currently smoking\n10. Alcohol intake \\>3 drinks per day or \\>14 drinks per week",{"count":309,"type":20},20,[23],"The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD). Participants will undergo a randomized controlled trial, with circadian intervention and control (healthy lifestyle) groups. The circadian intervention is designed to reduce nighttime light exposure and after-dinner snack food intake. Alternatively, the control group will receive basic health information (e.g., physical activity, goal setting, and nutrition when eating out).",[313,287,151,314,27,284,285,286,154],"Cardiometabolic Syndrome","Time Restricted Feeding",{"date":294,"type":32},{"date":317,"type":32},"2023-06-13",{"date":319,"type":20},"2026-03",{"name":172,"class":39},{"id":322,"slug":323,"hasResults":11,"nctId":324,"briefTitle":325,"officialTitle":325,"acronym":4,"eligibilityCriteria":326,"healthyVolunteers":79,"sex":327,"minAge":4,"maxAge":4,"enrollmentInfo":328,"targetDuration":4,"studyType":21,"phases":330,"briefSummary":331,"conditions":332,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":340,"startDateStruct":342,"completionDateStruct":344,"leadSponsor":346,"locationsCount":71},"100506168","generation-r-next---optimaal-opgroeien-100506168","NCT05870878","Generation R Next - Optimaal Opgroeien","Inclusion Criteria:\n\nWomen and their parents:\n\n* Planning a pregnancy or early pregnancy up to \\\u003C 12 weeks\n* With the presence of at least one of the predetermined risk factors\n* Residential address in the municipality of Rotterdam and expected residential address in the municipality of Rotterdam at the birth of their child\n* Consent for participation\n\nExclusion Criteria:\n\nWomen and their partners:\n\n* Temporary or complete withdrawal from participation\n* Gestational age \\> 12+0 at study entry","FEMALE",{"count":329,"type":20},1750,[23],"The aim of this randomized controlled trial is to improve birth outcomes and long-term outcomes in mother and child by optimizing lifestyle,nutrition and stress experience in the preconception period and early pregnancy in women and men\n\nThe main research question that will be addressed is: Does an intervention focused on optimizing preconception and early pregnancy lifestyle, nutrition and stress improve the birth outcomes and long-term outcomes in mother and child?\n\nParticipants will receive an individual lifestyle consultation at the start of the study. Depending on their study arm, participants will receive an additional lifestyle program focused on health during preconception and early pregnancy, coping with stress and adherence to a healthy(er) lifestyle. The given advices are based on national guidelines.\n\nResearchers will compare the intervention group and control group to see if (adherence to) this lifestyle program improve birth outcomes and long-term outcomes in mother and child.",[333,334,27,335,336,337,338],"Pregnancy Early","Outcome, Adverse Birth","Preconception Care","Pregnancy Outcome","Pregnancy Complications","Risk Reduction Behavior","2024-08-30",{"date":341,"type":32},"2024-09-04",{"date":343,"type":32},"2023-01-19",{"date":345,"type":20},"2030-11-08",{"name":347,"class":39},"Erasmus Medical Center",{"id":349,"slug":350,"hasResults":11,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":354,"eligibilityCriteria":355,"healthyVolunteers":79,"sex":15,"minAge":49,"maxAge":145,"enrollmentInfo":356,"targetDuration":4,"studyType":21,"phases":358,"briefSummary":359,"conditions":360,"keywords":363,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":71},"100544380","climbing-lifestyle-intervention-for-modifying-physical-activity-behaviors-pilot-study-100544380","NCT06368128","Climbing Lifestyle Intervention for Modifying Physical Activity Behaviors: Pilot Study","Climbing Lifestyle Intervention for Modifying Physical Activity Behaviors (CLIMB): Pilot Study","CLIMB","Inclusion Criteria:\n\n* Physically inactive\n* Membership to Physical Education Instructional Facility at Northern Michigan University\n* No\u002Fvery little experience with rock climbing\n* No diagnosed cardiovascular, metabolic, renal disease\n* No current injury\n\nExclusion Criteria:\n\n* Physically active\n* Experience with rock climbing\n* No current membership with Physical Education Instructional Facility at Northern Michigan University\n* Pregnant and\u002For breastfeeding\n* Diagnosis of cardiovascular disease, metabolic disease, renal disease\n* Current or previous injury that would be exacerbated by rock climbing\n* Other diagnosed conditions in which rock climbing would be contraindicated",{"count":357,"type":20},12,[23],"The aim of this pilot study is to determine the effects of a 12-week indoor rock climbing training program on heart health, mental health, and behavioral health in generally healthy adults aged 18-35 years old who do not exercise. Participants will learn to rock climb using ropes on an indoor rock climbing wall and participate in the training program 2-3 days per week for 60 minutes each session over 12 weeks. Health outcomes will be measured at 4 time points over the course of the study (pre-intervention, 6-weeks\u002Fmid-intervention, 12-weeks\u002Fpost-intervention, and 24-weeks post-intervention).",[27,361,362],"Physical Inactivity","Quality of Life",[364,365,361,362],"Rock Climbing","Cardiovascular Disease Risk Factors","2024-07-15",{"date":368,"type":32},"2024-07-16",{"date":370,"type":32},"2024-04-16",{"date":372,"type":20},"2024-12-31",{"name":374,"class":39},"Northern Michigan University",{"id":376,"slug":377,"hasResults":11,"nctId":378,"briefTitle":379,"officialTitle":380,"acronym":4,"eligibilityCriteria":381,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":382,"enrollmentInfo":383,"targetDuration":4,"studyType":21,"phases":385,"briefSummary":386,"conditions":387,"keywords":388,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":393,"startDateStruct":395,"completionDateStruct":397,"leadSponsor":399,"locationsCount":401},"100541063","using-ai-text-messaging-to-improve-ahas-lifes-essential-8-health-behaviors-100541063","NCT06324981","Using AI Text Messaging to Improve AHA's Life's Essential 8 Health Behaviors","Using Artificially Intelligent Text Messaging Technology to Improve American Heart Association's Life's Essential 8 Health Behaviors: LE8 Bot + Backup","Inclusion Criteria:\n\n* diagnosis of one or more of the following CV risk factors (i.e., hypertension, diabetes or hyperlipidemia); and\n* the risk factor is at poor or intermediate health levels as defined by LE8 (e.g., BP\\>140\u002F90 mm Hg); and\n* the patient exhibits poor adherence to prescribed medication to treat the CV risk factor as defined by a delay in refilling the medication within the past 6 months.\n\nExclusion Criteria:\n\n* patients who do not have cellphone; or\n* enrolled in hospice or palliative care; or\n* Non-English or Spanish speaking; or\n* enrolled in another clinical trial if denoted in the EHR.","89 Years",{"count":384,"type":20},2100,[23],"The goal of our pragmatic clinical trial is to compare how well three different strategies might do to reduce risk factors for cardiovascular disease in patients experiencing health disparities. The three different strategies are: 1) text messages, 2) interactive chatbot messages, and 3) chatbot messages with proactive pharmacist support. To measure cardiovascular risk factors, the investigators are using the American Heart Association's Life's Essential 8 (LE8) factors-blood glucose, cholesterol, blood pressure, physical activity, body mass index, diet, and smoking.\n\nThis study focuses on improving cardiovascular risk factors for individuals facing health disparities, such as ethnic minorities, limited English proficiency, and low-income groups. These groups are more likely to be seriously affected by cardiovascular diseases. Self-management, or an individual's roles in managing their own chronic disease, includes lifestyle changes, medication adherence. Improving patients' self-management has been shown to improve health behaviors, better disease control and improved patient outcomes.\n\nThe main question this study aims to answer is if one of the strategies (texting, chatbot, or chatbot with pharmacist support) may improve patient self-management and patient outcomes.\n\nThe investigators will enroll up to 2,100 patients from three health systems that serve large populations experiencing health disparities: Denver Health, Salud Family Health Centers, and STRIDE Community Health Center.\n\nThe results might help researchers and health care systems find the best ways to involve patients with health disparities to managing their chronic cardiovascular disease.",[26,27],[389,390,391],"cardiovascular disease","Life's Essential 8","mHealth","2024-03-14",{"date":394,"type":32},"2024-03-22",{"date":396,"type":32},"2024-02-26",{"date":398,"type":20},"2028-06",{"name":400,"class":39},"University of Colorado, Denver",3]