[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lifestyle-intervention\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lifestyle-intervention":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,60,124,162,191,218,246,280,306,333,361,386,415],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":40,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100644951","the-impact-of-enhanced-music--natural-visuals-on-emotional-health-100644951",false,"NCT07676110","The Impact of Enhanced Music & Natural Visuals on Emotional Health","Impacts of Music, Audio Enhancements, Audio Guidance, and Visuals on Physical and Emotional Well-being. (Emotional Health - Longitudinal 1 Randomized, Controlled Multi-center Study)","Inclusion Criteria:\n\n* You are 13 years of age or older\n* You can read, write, and speak English at a 5th-grade level or higher\n* You are legally capable of providing informed consent (adult participants) or capable of providing assent (child participants)\n* To the best of your knowledge, you are willing and able to commit to the session(s) and activities of this study\n* You are willing and able to use the sound-delivery and data-collection apparatus of this study\n* You are willing to use your own personal equipment. Depending on the study, you may need to have your own ear buds\u002Fheadphones and\u002For a \"smart\" device with internet and\u002For Bluetooth access (e.g., smartphone, iPad).\n* You have normal hearing in both ears.\n* You never experience ringing noises or buzzing sensations in your ears (tinnitus)\n* You do not use a heart\u002Fcardiac pacemaker and do not have any history of cardiac rhythm disturbances, such as cardiac conduction delays or blocks\n* You have no known history of fainting, fainting, spells or seizures, spinning sensations, or trouble with balance (medical terms include epilepsy, seizures, syncope, vertigo, nystagmus)\n* You do not use of any of the following medications: Beta blockers, steroids, ephedrine, acute anti-anxiety medication (e.g., benzodiazepines such as diazepam\u002FValium, lorazepam\u002FAtivan or clonazepam\u002FKlonopin), or acute or chronic pain medications (including narcotics and codeine)\n* For any study session, you will not be under the influence of any substances that could prevent safe participation and will not have consumed e.g., alcohol, THC, Psilocybin, or other mood-altering drugs in the 12 hours preceding the session.\n\nExclusion Criteria:\n\n\\-",true,"ALL","13 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","The investigators are conducting research on factors related to the self-regulation of mood and arousal states across a range of everyday activities as well as different levels of stress. Behavioral interventions-such as meditation, listening to music, or visualizing art or nature-offer important alternatives and\u002For adjunctive strategies to pharmaceutical tools or other mechanisms supporting physical and emotional well-being. This research will expand on the knowledge base regarding the impact of biophysical stimulation and\u002For frame of mind on an individual's self-directed management of physical and emotional health. Motivation, confidence, and composure are critical aspects of self-efficacy, framing a person's mindset to make healthy choices across daily activities.\n\nThe research in this protocol is carried out across multiple sites and studies by means of digital tools and a consistent participant experience workflow. Together, these resources are intended to support individuals across multiple self-directed experiences utilized in the maintenance of their basic health. Before, during, and after session experiences, the participant provides objective (physiological) responses and\u002For subjective (self-report) responses and reflections; some studies also include interviews or focus groups. The combined set of responses can be summarized, connected to other measures, and input to machine learning models to improve personalization of stimuli. By studying the effects of soundBrilliance experiences across a variety of contexts and participant samples, the investigators can better refine each element of the stimulus to improve satisfaction, tolerance, and targeted outcomes.",[27,28,29,30,31,32,33,34,35,36,37,38,39],"Emotion Management Skills","Lifestyle, Healthy","Lifestyle Intervention","Recovery","Exercise and Recovery","Exercise Training","Anxiety and Mood Disorders","Sleep","Motivation","Comfort","Pain Management","Rehabilitation","Creativity and Mindfulness",[41,42,43,44,45,46],"Music","Visuals","Visual Imagery","Biophysical Stimuli","Emotional Health","Emotional Management","RECRUITING","2026-06-23",{"date":50,"type":51},"2026-06-30","ACTUAL",{"date":53,"type":51},"2026-05-25",{"date":55,"type":21},"2027-06",{"name":57,"class":58},"soundBrilliance LLC","INDUSTRY",3,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":4,"eligibilityCriteria":66,"healthyVolunteers":11,"sex":17,"minAge":67,"maxAge":4,"enrollmentInfo":68,"targetDuration":4,"studyType":22,"phases":70,"briefSummary":71,"conditions":72,"keywords":77,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":123},"100639482","simplifying-diet-tracking-in-a-digital-weight-loss-intervention-100639482","NCT07601061","Simplifying Diet Tracking in a Digital Weight Loss Intervention","Simplifying Dietary Self-Monitoring in a Digital Weight Loss Intervention","Inclusion Criteria:\n\n* adults (ages 18+ years)\n* body mass index (BMI) 25.0 to 45.0 kg\u002Fm\\^2\n* smartphone ownership\n* willing to install a mobile app on personal smartphone\n* access to a personal email account\n* English or Spanish language proficiency\n* interest in losing weight through behavioral strategies\n* living in the United States\n* willing to be randomized\n\nExclusion Criteria:\n\n* concurrent enrollment in another weight management intervention\n* loss of ≥5% weight in the past 6 months\n* prior or planned bariatric surgery during the trial period\n* current or planned pregnancy during the trial period, or recent pregnancy in the past 6 months\n* currently breastfeeding or lactating\n* current use of anti-obesity medications\n* living with someone else participating in the study\n* hospitalization for a mental health condition in the past 12 months\n* inability to engage in moderate forms of physical activity akin to brisk walking\n* medical or psychiatric contraindication (e.g., end stage renal disease, cancer, schizophrenia, dementia, use of steroids, use of antipsychotic medication)\n* if an individual would be better suited for a more intensive or different type of intervention based on a health condition (e.g., individuals with history of an eating disorder or cardiovascular event, uncontrolled hypertension, or uncontrolled diabetes mellitus)\n* investigator discretion for safety reasons","18 Years",{"count":69,"type":21},328,[24],"The purpose of this study is to compare two approaches for tracking dietary intake in a 12-month fully digital weight loss intervention: (1) Simplified approach: track Red Zone Foods (e.g., foods high in calories and low in nutritional value) vs. (2) Detailed approach: track all foods and their corresponding calories. In essence, this is a head-to-head comparison of two tracking approaches; the investigators are evaluating whether weight loss is comparable over 12 months, or whether one approach will have greater weight loss.\n\nThe investigators will recruit 328 adults. Broadly, adults with overweight or obesity who live in the United States will be eligible. The weight loss intervention will last 12 months. All participants will be asked to track their dietary intake + body weight + steps daily as well as complete weekly behavioral lessons and action plans to promote healthy eating and physical activity. All study tasks will occur remotely. Assessment of body weight and survey measures will occur at the beginning of the trial (\"baseline\"), and at 1, 6, 12, and 18 months.",[73,74,75,76,29],"Overweight","Obesity","Weight Loss","Health Behavior",[78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111],"digital intervention","behavioral intervention","behavior change","obesity","body weight","overweight","BMI","diet","tracking","track","self-monitoring","self-monitor","lifestyle","adults","intervention","weight loss","weight loss intervention","weight reduction","weight management","red zone foods","calorie counting","noninferiority trial","non-inferiority","comparative effectiveness trial","comparative effectiveness","RCT","randomized clinical trial","digital health","mobile health","obesity treatment","obesity management","remote intervention","standalone intervention","standalone","NOT_YET_RECRUITING","2026-05-22",{"date":115,"type":51},"2026-05-28",{"date":117,"type":21},"2027-05-01",{"date":119,"type":21},"2030-10-31",{"name":121,"class":122},"Stanford University","OTHER",1,{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":16,"sex":17,"minAge":132,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":22,"phases":136,"briefSummary":137,"conditions":138,"keywords":144,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":123},"100620930","the-brain-health-pro-online-risk-factor-reduction-study-to-prevent-dementia-100620930","NCT07364019","The Brain Health PRO Online Risk Factor Reduction Study to Prevent Dementia","The Brain Health PRO Online Risk Factor Reduction Study for The Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia","BHPROOF","Inclusion Criteria:\n\n* Completion and documentation of the electronic Informed Consent Process (from the participant)\n* Sufficient proficiency in English or French to undergo online assessments and participate in an online educational program.\n* Technical ability to participate in an online educational program and remote assessments (i.e., regularly have access to a computer or tablet with an internet connection; have access to a desktop or laptop computer with an internet connection at least once every 6 months; ability to send and receive emails; ability to complete online assessments)\n* Sufficient vision to participate in an online educational program and complete online cognitive testing\n* Ages 50-80\n* Classified as being at increased risk of dementia based on at least one of the following:\n\n  * First-degree family history of dementia\n  * Education level at or below high school (grade 12 or less)\n  * Self-Reported: Hypertension, Hypercholesterolemia, Body Mass Index \\> 30 kg\u002Fm2 (derived from NIH Metric BMI Calculator), or Physical Inactivity (active is defined as engaging in a minimum of 20- 30 min of physical activity causing sweating and breathlessness, at least 2 times a week)\n\nExclusion Criteria:\n\n* Individuals who have a clinical diagnosis of Dementia (based on self-report)\n* Individuals who are currently participating in or have participated in a past study involving BHPro","50 Years","80 Years",{"count":135,"type":21},700,[24],"This study will recruit participants at risk for dementia to participate in an online educational program called Brain Health PRO (BHPro). The BHPro intervention is designed to address modifiable risk factors for dementia through a 6-month, fully online, educational program conveying the best available evidence for lifestyle changes that can mitigate dementia risk, and foster engagement toward one's own brain health. Achieving lifestyle changes in a diverse Canadian population through online education would be a major achievement in dementia prevention in Canada, with widespread personal and socioeconomic benefits.\n\nEligible participants will be randomly assigned to either start Brain Health PRO immediately or in 6 months (delayed-start control group). All participants will have the opportunity to have access to BHPro for 6 months during the course of the study and will have open access to all content for 12 months following the initial 6-month intervention. Participation will last from 18-24 months depending on group assignment.",[139,140,141,142,29,143],"Dementia Prevention","Subjective Cognitive Impairment","Mild Cognitive Impairment","Cognitive Change","Dementia Education",[145,146,147,148,149,150,151,152],"dementia education","at risk for dementia","lifestyle intervention","dementia reduction","dementia risk factor","dementia prevention","cognitive impairment","Alzheimer risk","2026-05-14",{"date":155,"type":51},"2026-05-19",{"date":157,"type":51},"2026-05-07",{"date":159,"type":21},"2028-12-31",{"name":161,"class":122},"University of British Columbia",{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":16,"sex":169,"minAge":67,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":22,"phases":172,"briefSummary":173,"conditions":174,"keywords":178,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":123},"100639722","effectiveness-of-an-ai-enabled-mobile-intervention-on-lifestyle-behaviors-and-maternal-infant-health-100639722","NCT07582068","Effectiveness of an AI-Enabled Mobile Intervention on Lifestyle Behaviors and Maternal-Infant Health","Effects of an AI-driven Mobile Health Management Intervention to Prevent Gestational Diabetes Mellitus in High-risk Pregnant Women: A Pragmatic Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women aged ≥18 years\n* Singleton pregnancy\n* Gestational age \\\u003C13+6 weeks at enrollment\n* At least one of the following GDM risk factors:\n\n  1. Age ≥35 years\n  2. Pre-pregnancy BMI ≥24 kg\u002Fm²\n  3. Family history of diabetes (first-degree relatives)\n  4. Previous history of gestational diabetes mellitus\n  5. Prior delivery of a macrosomic infant (birth weight ≥4000 g)\n* Polycystic ovary syndrome\n* Use of an Android smartphone\n* No severe heart, liver, or kidney diseases\n* Voluntary participation and signed informed consent\n\nExclusion Criteria:\n\n* Pre-pregnancy diagnosis of diabetes mellitus (type 1 or type 2)\n* Severe mental illness\n* Confirmed severe pregnancy complications (e.g., preeclampsia, placental abruption, etc.)\n* Inability to complete questionnaires or intervention\n* Participation in other interventional studies","FEMALE",{"count":171,"type":21},400,[24],"The goal of this pragmatic randomized controlled trial is to evaluate the effectiveness of an AI-enabled mobile health management application (\"Better Pregnancy\" app), grounded in the Theory of Planned Behavior, in preventing gestational diabetes mellitus (GDM) among pregnant women at high risk of GDM, and to assess its impact on maternal and infant health outcomes.\n\nStudy Population: Eligible participants are pregnant women aged 18-49 years, with a singleton pregnancy, gestational age \\\u003C12 weeks at enrollment, and at least one GDM risk factor (age ≥35 years, pre-pregnancy BMI ≥24 kg\u002Fm², family history of diabetes, previous history of GDM, prior delivery of a macrosomic infant \\[birth weight ≥4000 g\\], or polycystic ovary syndrome). Participants must have no heart, liver, or kidney diseases, use an Android smartphone, and provide written informed consent.\n\nThe main questions it aims to answer are:\n\nCan the AI-driven mobile lifestyle intervention reduce the incidence of GDM in high-risk pregnant women?\n\nDoes the intervention improve lifestyle behaviors (diet, physical activity, sleep) and glycemic control (measured by continuous glucose monitoring) in participants?\n\nWhat is the adherence, acceptability, and cost-effectiveness of this intervention in real-world clinical settings?\n\nComparison: Researchers will compare two groups of pregnant women: the intervention group (receiving the AI-enabled \"Better Pregnancy\" app plus routine antenatal care) and the control group (receiving routine antenatal care alone).\n\nParticipants will:\n\nEnroll in the first trimester (\\\u003C12 weeks of gestation) and complete a baseline lifestyle and health status questionnaire\n\nIn the intervention group: watch 7 cognitive-attitudinal videos within the first week, then complete 12 weeks of AI-driven personalized intervention (daily check-ins, receiving tailored recommendations on diet, physical activity, sleep, etc.)\n\nDuring the intervention period, participants in the intervention group will wear a continuous glucose monitoring device for 7 days to assess the impact of the intervention on glycemic fluctuations\n\nComplete the first follow-up lifestyle and health status assessment after the intervention (approximately in the second trimester)\n\nUndergo an oral glucose tolerance test during the second trimester (24-28 weeks)\n\nComplete the second follow-up lifestyle and health status assessment in the third trimester (≥28 weeks)\n\nComplete the third follow-up lifestyle and health status assessment at 42 days postpartum, along with collection of delivery outcomes and infant health information\n\nA subset of participants may voluntarily provide blood and stool samples for mechanistic studies",[175,29,176,177],"Mobile Health Apps","Prevention","Multi-component Based Behavioral Intervention",[176,179,180,181],"Gestational diabetes mellitus","Mobile health","Randomized controlled trial","2026-05-06",{"date":184,"type":51},"2026-05-12",{"date":186,"type":21},"2026-08-10",{"date":188,"type":21},"2027-12-31",{"name":190,"class":122},"Fangbiao Tao",{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":17,"minAge":67,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":22,"phases":201,"briefSummary":202,"conditions":203,"keywords":205,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":4},"100636454","gardening-for-health-for-cancer-survivors-100636454","NCT07565896","Gardening for Health for Cancer Survivors","Gardening for Health for Cancer Survivors (G4H-CS)","G4H-CS","Inclusion Criteria:\n\n* Age 18 years or older\n* Self-reported current or prior diagnosis of cancer\n* Self-identifies as a cancer survivor\n* Ability to read, write, and speak English\n\nExclusion Criteria:\n\n* Currently significantly immunosuppressed",{"count":200,"type":21},15,[24],"This study is testing whether a gardening and nutrition program can improve well-being in people who have had cancer. Many cancer survivors continue to experience challenges after treatment, including changes in appetite, nutrition, stress, and quality of life. Programs that combine healthy eating, physical activity, and social connection may help address these issues.\n\nIn this study, participants will take part in a 6-week, in-person program called Gardening for Health. The program includes weekly group sessions held at a garden at the University of Vermont Medical Center. Each session lasts about two hours and includes hands-on gardening activities, nutrition education, cooking demonstrations, and guided wellness practices such as mindfulness and light movement. Participants will also receive educational materials to support healthy eating and gardening at home.\n\nThe main goal of the study is to determine whether this program is feasible and acceptable for cancer survivors, meaning whether people are willing to participate, attend sessions, and find the program helpful and satisfying. The study will also explore whether participation is associated with improvements in quality of life, stress, sense of belonging, and nutrition-related behaviours.\n\nParticipants will complete questionnaires before starting the program and again after the 6-week program ends. These surveys will ask about overall health, stress levels, social connection, and lifestyle habits.\n\nThe researchers hypothesize that participation in the Gardening for Health program will be feasible and well-received by cancer survivors, and that it may lead to improvements in quality of life, reduced stress, and increased feelings of connection and well-being.\n\nThis is a single-group study, all participants receive the intervention and there is no comparison group. The results will help determine whether this type of program should be studied further in larger trials.",[204,29],"Quality of Life",[206,207,208],"Cancer Survivors","Gardening Therapy","Horticultural Therapy","2026-04-29",{"date":211,"type":51},"2026-05-04",{"date":213,"type":21},"2028-07",{"date":215,"type":21},"2042-07",{"name":217,"class":122},"University of Vermont Medical Center",{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":17,"minAge":67,"maxAge":225,"enrollmentInfo":226,"targetDuration":4,"studyType":22,"phases":228,"briefSummary":229,"conditions":230,"keywords":234,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":123},"100627540","effect-of-counselling-using-lifestyle-medicine-assessment-tool-on-hypertensive-patients-100627540","NCT07449962","Effect of Counselling Using Lifestyle Medicine Assessment Tool on Hypertensive Patients","Effect of Counselling of Patients With Hypertension Presenting in Family Medicine Clinics Using Lifestyle Medicine Assessment Tool.","Inclusion Criteria:\n\n1. Adult patients aged 18-65 yrs with diagnosed primary\u002Fessential hypertension, defined as two or more clinic BP readings of ≥130\u002F80 (ACC\u002FAHA Guidelines).\n2. If taking anti hypertensives, then on a stable regime i.e. no recent medication change for at least ≥4 weeks.\n3. Willing and able to participate in the study.\n\nExclusion Criteria:\n\n1. Diagnosed secondary hypertension.\n2. Moderate to severe CKD (eGFR \\\u003C60 ml\u002Fmin\u002F1.73m2).\n3. Moderate to severe ischemic heart disease.\n4. Diabetes Mellitus requiring insulin.\n5. Major psychiatric disorder such as dementia or schizophrenia.\n6. Pregnancy or Lactating mother.\n7. Unable to participate in study\u002F Severe mobility limitation.","65 Years",{"count":227,"type":21},64,[24],"The goal of this clinical trial is to learn if knowing and understanding a patient's daily habits and then giving clear advice on what changes to make can help control blood pressure better than the routine way of advising people with high blood pressure. The main questions it aims to answer are:\n\n* To learn if using the Lifestyle Medicine Assessment tool (A 21-item questionnaire) to understand the current lifestyle of people with hypertension and guide them accordingly, helps in lowering blood pressure more, as compared to routine advice?\n* To see if this way of guiding patients is more satisfactory for them then routine advice? Researchers will compare two groups of people with hypertension. One will be guided after assessing their current lifestyle with the Lifestyle Medicine Assessment Tool and one will be given routine guidance. The researchers will then see which group had better blood pressure control.\n\nParticipants will be:\n\n* Asked a few questions about their lifestyle and then they will be advised accordingly on ways to make it better.\n* They will also be asked to measure their blood pressure at home and bring the record with them when they come for their doctor's visit.",[29,231,232,233],"Lifestyle Modification","Hypertension","Counselling",[235,236],"lifestyle counselling of hypertensive patients","Lifestyle Medicine Assessment Tool","2026-04-25",{"date":239,"type":51},"2026-04-30",{"date":241,"type":21},"2026-06",{"date":243,"type":21},"2027-02",{"name":245,"class":122},"Indus Hospital and Health Network",{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":17,"minAge":67,"maxAge":4,"enrollmentInfo":253,"targetDuration":4,"studyType":22,"phases":255,"briefSummary":256,"conditions":257,"keywords":258,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":123},"100595447","reset-enhancing-weight-loss-in-a-digital-intervention-100595447","NCT07032571","Reset: Enhancing Weight Loss in a Digital Intervention","Enhancing Weight Loss in a Digital Intervention Among Adults With Overweight or Obesity","Inclusion Criteria:\n\n* adults (ages 18+ years)\n* body mass index (BMI) 25.0 to 45.0 kg\u002Fm\\^2\n* cellphone ownership with a texting plan\n* daily access to a personal scale\n* daily access to a personal email account\n* English language proficiency\n* interest in losing weight through behavioral strategies\n* living in the United States\n\nExclusion Criteria:\n\n* concurrent enrollment in another weight management intervention\n* loss of ≥5% body weight in the past 6 months\n* current use of a weight loss or anti-obesity medication\n* prior or planned bariatric surgery in the next 3 months\n* current pregnancy, planned pregnancy in the next 3 months, or recent pregnancy in the past 6 months\n* current breastfeeding or lactating\n* living with someone else participating in the study\n* hospitalization for a mental health condition in the past 12 months\n* inability to engage in moderate forms of physical activity akin to brisk walking\n* if weight loss is contraindicated or might be impacted by a condition (e.g., end stage renal disease, cancer, schizophrenia, dementia) or medication (e.g., steroids, antipsychotics)\n* if an individual would be better suited for a more intensive or different type of intervention based on a health condition (e.g., individuals with history of an eating disorder or cardiovascular event, uncontrolled hypertension, or uncontrolled diabetes mellitus)\n* participation in another weight loss study conducted in Dr. Patel's lab in the past 6 months\n* investigator discretion for safety reasons",{"count":254,"type":21},208,[24],"The goal of the Reset trial is to learn about the optimal combination of dietary behavior strategies in a fully digital weight loss intervention. The intervention is designed for adults with overweight or obesity. The investigators will examine the impact on weight loss of four dietary strategies: 1) limiting Red Zone Foods (i.e., foods that are high in calories and low in nutrition), 2) limiting eating windows, 3) increasing protein intake, and 4) increasing fiber intake. Each of these strategies will include goal setting, daily self-monitoring, and tailored feedback.\n\nThe investigators will recruit 208 participants. Broadly, adults with overweight or obesity who live in the U.S. will be eligible. The weight loss intervention will last 12 weeks. All participants will be asked to track their body weight daily and complete weekly behavioral lessons and action plans to promote healthy eating and physical activity. All study tasks will occur remotely. Assessment of body weight and survey measures will occur at the beginning of the trial (\"baseline\"), and at 1 month and 3 months.\n\nThe Multiphase Optimization Strategy (MOST) framework will be used to identify which combination of the dietary behavior strategies results in the greatest weight loss. In total, there will be 16 treatment conditions.",[74,73,75,76,29],[81,83,93,259,260,147,261,262,92,80,95,263,91,264,265,266,267,96,108,107,105,78,109,110,268,269,106,270,271],"weight","health behavior","lifestyle modification","multiphase optimization strategy","lose weight","BMI reduction","body fat reduction","weight control","weight change","obesity prevention","diabetes prevention","factorial design","intervention optimization","2026-02-28",{"date":274,"type":51},"2026-03-03",{"date":276,"type":21},"2026-04",{"date":278,"type":21},"2026-08",{"name":121,"class":122},{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":169,"minAge":67,"maxAge":132,"enrollmentInfo":287,"targetDuration":4,"studyType":22,"phases":289,"briefSummary":290,"conditions":291,"keywords":295,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":123},"100549283","a-study-of-the-intervention-of-time-restricted-eating-in-high-risk-populations-of-gdm-100549283","NCT06431997","A Study of the Intervention of Time-restricted Eating in High-risk Populations of GDM","Effects of Time-restricted Eating on the Incidence of Gestational Diabetes Mellitus in High-risk Populations: a Randomized Controlled Study","Inclusion criteria:\n\n1. Aged 18-50 years;\n2. The risk for GDM includes overweight or obesity (BMI ≥ 24 kg\u002Fm2 before pregnancy), first-degree relative with diabetes, history of cardiovascular disease, hypertension (≥130\u002F80 mmHg or on therapy for hypertension), HDL cholesterol level \\\u003C 1 mmol\u002FL and\u002For a triglyceride level \\> 2.8 mmol\u002FL, history of GDM, history of macrosomia delivery, individuals with polycystic ovary syndrome, repeated positive fasting urine glucose in the first trimester, or age\\>45 years according to Guideline of Diagnosis and Treatment of Hyperglycemia in Pregnancy (2022);\n3. Less than 14 weeks of gestation;\n4. Able to read and complete questionnaires in Chinese;\n5. singleton pregnancy.\n\nExclusion criteria:\n\n1. Pregestational diabetes (including diabetes diagnosed before conception; fasting blood glucose ≥ 7.0 mmol\u002FL or HbA1c ≥ 6.5% in the first trimester; typical symptoms of hyperglycemia or hyperglycemic crisis with optional blood glucose ≥ 11.1 mmol\u002FL);\n2. Impaired glucose tolerance (including fasting blood glucose ≥ 5.6 mmol\u002FL or two fasting blood glucose ≥ 5.1 mmol\u002FL in the first trimester);\n3. Current or recent use of drugs that affect glucose metabolism such as metformin, glucocorticoids and Orlistat;\n4. Severe comorbidities (including cardiac diseases, kidney diseases, hepatopathy, autoimmune diseases, uncontrolled thyroid disease, previous or current malignant tumors, etc.);\n5. Fetal malformations or chromosomal abnormalities;\n6. Cervical insufficiency (including ultrasonic cervical length \\\u003C 25 mm before 24 weeks of gestation, history of spontaneous preterm birth at 14-36 weeks of previous pregnancy, or cervical dilation in the past or current pregnancy);\n7. Exercise contraindications (including continuous vaginal bleeding, threatened premature labor, placenta previa, premature rupture of membranes, severe anemia, etc.);\n8. Drug abuse, which refers to the repetitive, heavy use of drugs with dependent characteristics such as narcotic, psychotropic substances, tobacco and alcohol;\n9. Hyperemesis gravidarum, which refers to the severe and persistent nausea and vomiting, unable to eat or eat little that leads to dehydration, ketosis and even acidosis;\n10. On a special or prescribed diet for other reasons;\n11. Eating window\\\u003C10 h.\n\nExit criteria：\n\n1. Failure to comply with or assume the corresponding responsibilities and obligations of the informed agreement;\n2. Pregnant women who terminate their pregnancy before completing GDM diagnosis and screening at 24-28 weeks of pregnancy will automatically withdraw from the group, such as severe fetal malformation, eclampsia, abortion, etc.\n3. Major diseases, such as particularly serious obstetric medical events, malignant tumors, serious cardiovascular and cerebrovascular diseases, brain injuries, paralysis and other major diseases, can not continue to accept this intervention plan and follow-up, and withdraw from the study;\n4. Accidental disability or death caused by non-intervention factors occurred during the study period, and he withdrew from the study;\n5. Subjects are subjectively unwilling to continue to accept the intervention program, and sign the withdrawal agreement to withdraw from the group on a voluntary basis, and decide whether to continue to follow up the pregnancy process and outcome according to the specific contents of the withdrawal statement.",{"count":288,"type":21},240,[24],"This is a randomized controlled trial, aiming to investigate whether a time-restricted eating (TRE) can reduce the incidence of gestational diabetes mellitus (GDM) in high-risk pregnant women. Investigators intend to conduct a 3-month randomized controlled study to compare the effects of 10-hour TRE and habitual eating time on GDM .",[292,293,29,294],"Gestational Diabetes Mellitus","Dietary Habits","Randomized Controlled Study",[292,296],"Metabolic Diseases","2025-11-18",{"date":299,"type":51},"2025-11-21",{"date":301,"type":51},"2024-04-17",{"date":303,"type":21},"2026-12",{"name":305,"class":122},"Fudan University",{"id":307,"slug":308,"hasResults":11,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":312,"eligibilityCriteria":313,"healthyVolunteers":11,"sex":169,"minAge":67,"maxAge":314,"enrollmentInfo":315,"targetDuration":4,"studyType":22,"phases":317,"briefSummary":318,"conditions":319,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":123},"100575087","effectiveness-of-a-lifestyle-intervention-for-pregnant-women-with-abnormal-glucose-metabolism-in-early-pregnancy-eagm-trial-100575087","NCT06767722","Effectiveness of a Lifestyle Intervention for Pregnant Women With Abnormal Glucose Metabolism in Early Pregnancy: EAGM Trial","Effectiveness of a Lifestyle Intervention for Pregnant Women With Abnormal Glucose Metabolism in Early Pregnancy: EAGM Randomized Controlled Trial","EAGM","Inclusion Criteria:\n\n* Over 18 years of age.\n* Able to provide informed consent.\n* Confirmed viable pregnancy on a nuchal translucency scan done between 11+0 and 13+6 weeks.\n* Singleton pregnancies.\n* An abnormal glucose metabolism determined by a blood test performed before 14 weeks, defined as FPG 5.1-6.9mmol\u002FL and\u002For HbA1c 5.7-6.4%.\n\nExclusion Criteria:\n\n* Pregestational diabetes (diagnosed as diabetes mellitus before pregnancy, or FPG≥7.0mmol\u002FL, or HbA1c≥6.5% at the first prenatal visit), impaired fasting glucose or impaired glucose tolerance diagnosed before pregnancy.\n* Plan for termination of pregnancy due to fetal anomaly identified at the first trimester scan.\n* Use of medications known to interfere with glucose metabolism (e.g. corticosteroids, antipsychotic drugs) at the time of randomisation.\n* Any other physical (serious medical conditions such as cancer, organ failure, epilepsy, paraplegia, disability) or psychological condition (e.g. learning difficulties, serious mental illness) that is likely to interfere with the conduct of the trial according to evaluation by the trial monitoring group.\n* Women currently with hyperemesis gravidarum leading to dehydration or requiring hospitalization. If persisting vomiting resolves, the patient may be reassessed for inclusion in the trial up to and including 14+6 weeks of gestation, providing all other inclusion and exclusion criteria are met.","55 Years",{"count":316,"type":21},3430,[24],"This is a multicentre, parallel-group, open-label, pragmatic, randomised-control trial of early lifestyle intervention versus routine prenatal care by random allocation (1:1) in women with early abnormal glucose metabolism (EAGM) to compare the incidence of large-gestational age and preterm birth between two groups. The investigators aim to assess the effectiveness of early lifestyle interventions and to provide evidence for the optimal standard management for Chinese women with EAGM.",[320,321,322,29,323],"Early Pregnancy","Fasting Plasma Glucose","Hemoglobin A1c Protein, Human","Adverse Pregnancy Outcomes","2025-06-25",{"date":326,"type":51},"2025-07-01",{"date":328,"type":51},"2025-04-16",{"date":330,"type":21},"2027-06-30",{"name":332,"class":122},"First Affiliated Hospital, Sun Yat-Sen University",{"id":334,"slug":335,"hasResults":11,"nctId":336,"briefTitle":337,"officialTitle":338,"acronym":4,"eligibilityCriteria":339,"healthyVolunteers":16,"sex":17,"minAge":67,"maxAge":4,"enrollmentInfo":340,"targetDuration":4,"studyType":22,"phases":342,"briefSummary":343,"conditions":344,"keywords":347,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":123},"100586674","evaluation-of-the-warifa-app-and-its-impact-on-healthy-lifestyle-100586674","NCT06918444","Evaluation of the WARIFA App and Its Impact on Healthy Lifestyle","Effect of the WARIFA App on User-defined Objectives, Healthy Lifestyles and Management of Type 1 Diabetes: a Pilot Randomised Controlled Trial","Inclusion Criteria:\n\n* Common for both population groups:\n* Adults over 18 years of age.\n* Owners of a smartphone operating with Android and with internet access.\n* Group 1: General population:\n* Healthy or diagnosed with no more than one NCD (CVD, any type of cancer, T2D or chronic respiratory disease).\n* Group 2: T1D:\n* Treatment with multiple subcutaneous insulin injections or an insulin pump.\n* Users of a continuous glucose monitor.\n\nExclusion Criteria:\n\n* Common for both groups:\n* Pregnancy.\n* Mobile device which is incompatible with the WARIFA app (E.g. Apple devices).\n* Unable to understand any of the app languages (Spanish, English, Norwegian or Romanian).\n* Any reason which precludes follow-up, based on the researcher's criteria.\n* Group 1: General population\n* People with two or more NCDs.",{"count":341,"type":21},104,[24],"The goal of this study is to assess the effect of the WARIFA app on the adoption of healthy lifestyle behaviours related to Non-communicable diseases (NCDs), as well as in the management of Type 1 Diabetes (T1D). This is done using user-generated data analysis, artificial intelligence (AI) and risk estimation to provide personalised recommendations on lifestyle-related behaviours through a mobile app.\n\n* Primary objective: the objective of this study is to assess the impact of using the WARIFA app on a series of outcomes, related to the promotion of healthy lifestyles and prevention of NCDs, as well as on the management of T1D.\n* Secondary objectives: to assess the feasibility of implementation of a complex health app (WARIFA), and to explore which outcomes are more relevant in this context for users.\n\nThe study will evaluate the app in two different populations:\n\n* Population 1: Citizens living in Europe of either sex aged \\> 18 years diagnosed with no more than one NCD (of the following: CVD, any type of cancer, chronic respiratory disease and T2D) and current owners of a smartphone with internet access.\n* Population 2: European adult individuals of either sex aged \\>18 years with T1D currently using multiple daily insulin injections or an insulin pump and current owners of a smartphone with internet access.\n\nThe study will be carried out in three centres in three different countries: the Instituto Universitario de Investigaciones Biomédicas y Sanitarias (iUIBS) in Spain, the Norwegian Centre for E-health Research (NSE) in Norway, and in Romania.\n\nParticipants in each population will be randomised to an intervention or control arm on a 1:1 ratio:\n\n* Intervention arm: the Warifa app will be used by the participants throughout the study. The app will provide personalised risk estimations and recommendations through user-generated data analysis and artificial intelligence.\n* Control arm: The control group will use a Warifa app with the same functionalities than the intervention arm, but without artificial intelligence.\n\nAt baseline, information will be collected by questionnaires and a physical examination, including anthropometry and a lipid profile. These measurements will be repeated in 12 weeks and will be compared between the treatment arms.\n\nThe study will last 3 months in total, start of recruitment on 10 February 2025, end of study after the last visit of the last participant, on 12 May 2025. Each user will participate in the study for 12 weeks.",[29,345,346],"Non Communicable Chronic Diseases","Type 1 Diabetes (T1D)",[348,349,350,345,351,346],"AI (Artificial Intelligence)","Mobile app","Lifestyle intervention","Risk Prediction Model","2025-04-06",{"date":354,"type":51},"2025-04-09",{"date":356,"type":51},"2025-02-24",{"date":358,"type":21},"2025-05-29",{"name":360,"class":122},"Instituto Universitario de Investigaciones Biomédicas y Sanitarias (iUIBS) de la Universidad de Las",{"id":362,"slug":363,"hasResults":11,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":16,"sex":17,"minAge":368,"maxAge":4,"enrollmentInfo":369,"targetDuration":4,"studyType":22,"phases":371,"briefSummary":372,"conditions":373,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":377,"lastUpdatePostDateStruct":378,"startDateStruct":380,"completionDateStruct":382,"leadSponsor":384,"locationsCount":123},"100582370","a-multi-language-smartphone-based-healthy-lifestyle-intervention-for-firefighters-100582370","NCT06862427","A Multi-language Smartphone-based Healthy Lifestyle Intervention for Firefighters","A Multi-language Smartphone-based Healthy Lifestyle Intervention for Firefighters: A Cluster Randomized Controlled Trial","Inclusion Criteria:\n\n* Career firefighters who are older than or equal 20 years old\n\nExclusion Criteria:\n\n* Career firefighters who are younger than 20 years old\n* Firefighters who are retired or are volunteer firefighters.","20 Years",{"count":370,"type":21},1000,[24],"The goal of this cluster randomized controlled trial is to evaluate the effects of a smartphone-based Healthy Lifestyle (HLS) intervention on firefighters' mental and physical health in firefighters in Tainan, Taiwan. The main questions it aims to answer are:\n\n* Does the Traditional Chinese version of the HLS mobile App improve firefighters' mental and physical health compared to usual care?\n* Can the intervention effectively promote a healthy lifestyle and reduce the risk of chronic non-communicable diseases among firefighters?\n\nResearchers will compare firefighters receiving the smartphone-based HLS intervention to those receiving usual care to determine whether the intervention leads to improved health and fitness outcomes over 3 to 6 months.\n\nParticipants will:\n\n* Use the Traditional Chinese version of the HLS mobile App, originally developed at Cambridge Health Alliance, Harvard Medical School, and adapted for firefighters in Taiwan.\n* Be randomly assigned to either the intervention group (HLS App) or the control group (usual care).\n* Undergo health and fitness assessments at baseline and at 3 to 6 months post-intervention.\n\nAnticipated outcomes are improvements in mental and physical health among firefighters receiving the intervention compared to the control group.",[374,375,376,29],"Mental Health","Physical Performance","Cardiovascular Health","2025-03-16",{"date":379,"type":51},"2025-03-20",{"date":381,"type":51},"2025-03-04",{"date":383,"type":21},"2025-12",{"name":385,"class":122},"National Yang Ming Chiao Tung University",{"id":387,"slug":388,"hasResults":11,"nctId":389,"briefTitle":390,"officialTitle":391,"acronym":392,"eligibilityCriteria":393,"healthyVolunteers":11,"sex":17,"minAge":132,"maxAge":4,"enrollmentInfo":394,"targetDuration":4,"studyType":22,"phases":396,"briefSummary":397,"conditions":398,"keywords":402,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":414},"100580089","lifestyle-intervention-in-the-memory-clinics-of-general-and-academic-hospitals-trial-100580089","NCT06832761","Lifestyle Intervention in the Memory Clinics of General and Academic Hospitals Trial","Secondary Prevention of Dementia in Memory Clinics: Implementation and (Cost-)Effectiveness of an Integrated Lifestyle Intervention","LIGHT","Inclusion Criteria:\n\n* ≥50 years of age at pre-screening;\n* Having a diagnosis of SCD or MCI;\n* Presence of ≥ 2 modifiable risk factors for dementia.\n\nExclusion Criteria:\n\n* Having a diagnosis of dementia;\n* Insufficient understanding of the Dutch language;\n* Conditions affecting safe and continuous engagement in the intervention (e.g. under treatment for current malignant diseases, major psychiatric disorders (e.g. major depression, psychosis, bipolar disorder), other conditions preventing co-operation as judged by the local study nurse or consulted physician at the local study site;\n* Participation in any other research intervention trial at time of pre-screening and throughout the study period.",{"count":395,"type":21},300,[24],"Lifestyle Intervention in the memory clinics of General and academic Hospitals Trial (LIGHT) is a multi-center, randomized, controlled, lifestyle intervention trial among 300 older adults (≥50 years) with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) at risk of dementia. Participants are randomized in a 1:1 ratio to Group A (tailored lifestyle intervention) or Group B (general health advice) for a duration of 12 months. The lifestyle intervention comprises three parts 1) Lifestyle coaching, 2) a voucher program, and 3) online self-management. Group B will receive general health advice.",[29,399,400,401],"Lifestyle Risk Reduction","Cognitive Decline","Dementia",[350,403,401,404],"Risk reduction","Memory clinic","2025-02-12",{"date":407,"type":51},"2025-02-18",{"date":409,"type":51},"2025-01-27",{"date":411,"type":21},"2027-12",{"name":413,"class":122},"Maastricht University Medical Center",2,{"id":416,"slug":417,"hasResults":11,"nctId":418,"briefTitle":419,"officialTitle":420,"acronym":4,"eligibilityCriteria":421,"healthyVolunteers":16,"sex":17,"minAge":422,"maxAge":4,"enrollmentInfo":423,"targetDuration":4,"studyType":22,"phases":425,"briefSummary":426,"conditions":427,"keywords":429,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":431,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":123},"100406032","internet-technology-based-life-style-and-care-intervention-for-risk-factors-of-non-communicable-diseasesncd-100406032","NCT04567121","Internet Technology Based Life-style and Care Intervention for Risk Factors of Non Communicable Diseases（NCD）","Internet Technology Based Life-style and Care Intervention for Risk Factors of Non Communicable Diseases（NCD）-a Randomized, Controlled Trial in Communities Following Up for 50 Years","Inclusion Criteria:\n\n* Men and women older than 25 years of age with two or more risk factors as follows, BMI≥24 or BMI≤18.5 kg\u002Fm2, smoking, active exercise less than 30 minutes every day, blood pressure higher than 130\u002F85 mmHg, dyslipidemia, fasting glucose higher than 6.1mmol\u002Fl, fatty liver.\n* Patients with hypertension, diabetes and ASCVD\n\nExclusion Criteria:\n\n* Patients had not signed the consent form\n* Patients with severe heart failure, hepatic failure, renal failure and malignant tumor.\n* Patients planing pregnancy","25 Years",{"count":424,"type":21},60000,[24],"This study aims to control risk factors of non communicable diseases by life style and care intervention based on internet technology, looking forward to improve cardiovascular and cerebrovascular complications, diabetes and all-cause death.",[29,428],"Non Communicable Diseases",[430,147,428],"Internet Technology","2025-02-09",{"date":433,"type":51},"2025-02-11",{"date":435,"type":51},"2018-01-01",{"date":437,"type":21},"2070-12-01",{"name":439,"class":122},"Beijing Tsinghua Chang Gung Hospital"]