[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lifestyle\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lifestyle":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,70,99,126,150,183,208,239,263,287,314,348],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":43,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":69},"100346729","psychosocial-environmental-and-chronic-disease-trends-in-puerto-rico-100346729",false,"NCT03794531","Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico","Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends","PROSPECT","Inclusion Criteria:\n\n1. Age 30-75 years old at the time of enrollment\n2. Non-institutionalized\n3. Living in PR at the time of the first interview and the year before and not planning to move from the island within 3 years\n4. Able to answer questions without assistance\n5. Living in a stable dwelling\n\nExclusion Criteria:",true,"ALL","30 Years","75 Years",{"count":22,"type":23},2500,"ESTIMATED","OBSERVATIONAL","The overall goal is to identify trends and longitudinal associations in psychosocial, food-related, and cardiometabolic risk factors that can guide public health priorities and future research needs aimed at reducing cardiovascular-related disparities in Puerto Rico. To this end, investigators will establish 'PROSPECT: Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic disease Trends', an island-wide, longitudinal population cohort of 2,500 adults (30-75 years) in PR recruited with a community-wide sampling strategy, and assessed in a network of several partner clinics across the island. The study will collect comprehensive data on multiple psychosocial, dietary, and food-related factors, CVD biological markers, and medical record data, with follow-up at 2-years, and will assess variations by urban-rural area and by timing before-after Maria.",[27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42],"Heart Diseases","Type2 Diabetes","Hypertension","Obesity","Dyslipidemias","Metabolic Syndrome","Cardiovascular Diseases","Chronic Disease","Inflammation","Psychological Stress","Physiological Stress","Depressive Symptoms","Coping Behavior","Diet Habit","Lifestyle","Food Insecurity",[44,45,46,47,48,49,50,51,52,53,54,55,56],"Hispanics\u002FLatinos","Minority health","Puerto Rico","Cardiovascular disease","Cardiometabolic health","Chronic disease risk factors","Disaster research","Caribbean and Latin America","Population health","Prospective study","Allostatic load","Food insecurity","Longitudinal study","RECRUITING","2026-04-30",{"date":60,"type":61},"2026-05-05","ACTUAL",{"date":63,"type":61},"2019-03-01",{"date":65,"type":23},"2029-04-30",{"name":67,"class":68},"Harvard School of Public Health (HSPH)","OTHER",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":18,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":69},"100544943","real-time-engagement-for-learning-to-effectively-control-type-2-diabetes-100544943","NCT06375460","Real-time Engagement for Learning to Effectively Control Type 2 Diabetes","REFLECT2D","Inclusion Criteria:\n\n* type 2 diabetes: negative diabetes autoantibodies, no suspicion for monogenic diabetes\n* HbA1c ≥7.0%, stable medication use\n* HbA1c 6.0-6.9% without short-acting insulin, any other stable diabetes medication use\n* English-speaking (app in English)\n\nExclusion Criteria:\n\n* Current pregnancy\n* Hydroxyurea use (CGM sensor inaccuracies)\n* Cognitive impairment or severe psychiatric condition that could interfere with participation in behavioral intervention for diabetes self-management\n* Current or previously diagnosed eating disorder","16 Years","24 Years",{"count":80,"type":23},100,"INTERVENTIONAL",[83],"NA","This is a clinical trial that includes a run-in period, a 90 day micro-randomized trial, and a 90-day observational period. The goal of this study is to evaluate whether providing paired real time glycemic and health behavior data in a smartphone app leads to better glycemic control among adolescents and young adults with T2D. Glycemic control will be monitored using Continuous Glucose Monitors (CGM), and health behavior data will be collected via a Fitbit activity tracker and a research app (Healthmine). Participants will be prompted to view and reflect on glycemic trends and health behavior data (Fitbit data, logging of diet and medication adherence) during the 90-day micro-randomized trial period, then observed for ongoing use of the Healthmine app and engagement with CGM in the following 90-day observation period.",[86,41,87,88],"Diabetes Mellitus, Type 2","Hyperglycemia","Physical Inactivity","NOT_YET_RECRUITING","2026-04-22",{"date":92,"type":61},"2026-04-24",{"date":94,"type":23},"2026-07",{"date":96,"type":23},"2029-08",{"name":98,"class":68},"University of Pittsburgh",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":17,"sex":18,"minAge":106,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":108,"conditions":109,"keywords":112,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":69},"100633353","implementation-of-decade-of-healthy-ageing-action-plan-to-screen-and-prevent-decline-in-intrinsic-capacity-in-elders-spice-through-multisectoral-collaboration-in-singapore-100633353","NCT07525583","Implementation of Decade of Healthy Ageing Action Plan to Screen and Prevent Decline in Intrinsic Capacity in Elders (SPICE) Through Multisectoral Collaboration in Singapore","SPICE","Inclusion Criteria:\n\n* pre-frail or robust older adults who can provide consent and follow instructions\n\nExclusion Criteria:\n\n* frail or with terminal illness","60 Years",{"count":22,"type":23},"This study evaluates the implementation of a structured community-based pathway to screen, risk stratify, and prevent decline in intrinsic capacity (IC) among adults aged 60 years and above in Singapore. Using the World Health Organization (WHO) Integrated Care for Older People (ICOPE) framework and digital screening tools, participants will undergo IC domain screening in community settings. Individuals identified with early decline will receive targeted multidomain interventions and\u002For referral to primary or specialist care as indicated. Participants will be followed longitudinally to assess feasibility, uptake, functional trajectories, and implementation outcomes.",[110,111,41],"Frailty","Intrinsic Capacity",[113,114,115,116],"intrinsic capacity","personalized intervention","frailty","geroscience","2026-04-10",{"date":119,"type":61},"2026-04-13",{"date":121,"type":61},"2025-04-01",{"date":123,"type":23},"2027-09-30",{"name":125,"class":68},"National University Hospital, Singapore",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":17,"sex":18,"minAge":134,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":136,"conditions":137,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":69},"100537841","relationship-between-lifestyle-indicators-and-cardiovascular-clinical-parameters-100537841","NCT06283069","Relationship Between Lifestyle Indicators and Cardiovascular Clinical Parameters","Relationship Between Lifestyle Indicators (Healthy Behaviours) and Cardiovascular Clinical Parameters (Healthy Factors)","RICH","Inclusion Criteria:\n\n\\- ability to provide informed consent in compliance with the rules of Good Clinical Practice and current national regulations\n\nExclusion Criteria:\n\n* inability to fill in the questionnaire\n* inability to provide informed consent\n* unwillingness to participate in the study","6 Years",{"count":80,"type":23},"The goal of the study is to build a Register accruing data derived from the compilation of the questionnaire about LifeStyle for a population both of adults and of young boys and girls. The investigators are confident that in this way they will be able to expand the database they already have. The investigators will be able to increase the strength of the correlations between LS indices and health indicators. In particular, the investigators will emphasize the relationship between physical activity, stress, and diet quality on one hand, and on the other, they will focus on physiological parameters, like arterial pressure, gluco-lipid profile, and possible pathologies.",[33,41,138,88,139,140],"Nutrition, Healthy","Stress","Sleep","2025-11-17",{"date":143,"type":61},"2025-11-18",{"date":145,"type":61},"2023-05-01",{"date":147,"type":23},"2033-04-30",{"name":149,"class":68},"Istituto Auxologico Italiano",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":18,"minAge":158,"maxAge":4,"enrollmentInfo":159,"targetDuration":4,"studyType":81,"phases":161,"briefSummary":162,"conditions":163,"keywords":169,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":182},"100563076","strong-for-surgery--strong-for-life---intensive-prehabilitation-for-risk-reduction-in-ventral-hernia-repair-100563076","NCT06611462","STRONG for Surgery & Strong for Life - Intensive Prehabilitation for Risk Reduction in Ventral Hernia Repair","Effect of Tailored, Intensive Prehabilitation for Risky Lifestyles Before Ventral Hernia Repair on Postoperative Outcomes, Health, and Costs - a Randomised Controlled Trial (STRONG-Hernia)","STRONG-Hernia","Inclusion Criteria:\n\n* Participants ≥18 years scheduled for ventral hernia repair (defect smaller than 8cm)\n* Enough time for at least 4 weeks of prehabilitation\n* Screened positive for at least 1 risky SNAP factor\n* Signed informed consent\n\nExclusion Criteria:\n\n* Ventral hernia repairs with defect larger than 8 cm\n* Pregnancy\u002Fbreastfeeding\n* Allergy\u002Fother contradiction to pharmaceutical and\u002For nutritional support\n* Contradiction to exercise\n* Previous complicated alcohol withdrawal symptoms (delirium or seizures)\n* Not able to participate in intervention due to psychiatric ilness","18 Years",{"count":160,"type":23},400,[83],"The five risky lifestyles Smoking, Nutrition (obesity and malnutrition), risky Alcohol intake, and Physical inactivity (SNAP) are common in surgical patients and associated with worse postoperative outcomes. Mono-factor interventions targeting and improving these risky lifestyles have been shown to reduce the risk at surgery, but there is a lack of systematic assessment of all five lifestyles of the patient before surgery and related optimization.\n\nThis study aims to evaluate the effect of intensive combined lifestyle interventions (the STRONG programme) compared with treatment as usual in patients undergoing ventral hernia repair on postoperative complications, health, and costs on short and longer term.\n\nThe hypothesis is that the STRONG programme will halve the complication rates within 30 days.",[164,165,166,41,167,168],"Ventral Hernia","Surgery","Risk Reduction","Postoperative Complications","Prehabilitation",[164,165,166,167,168,170,171,30,172,88],"Smoking","Alcohol drinking","Malnutrition","2024-09-20",{"date":175,"type":61},"2024-09-25",{"date":177,"type":61},"2024-03-04",{"date":179,"type":23},"2028-03-01",{"name":181,"class":68},"Bispebjerg Hospital",3,{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":18,"minAge":189,"maxAge":4,"enrollmentInfo":190,"targetDuration":4,"studyType":81,"phases":191,"briefSummary":192,"conditions":193,"keywords":195,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":69},"100494701","effectiveness-of-integrated-care-combined-nutrition-and-lifestyle-counselling-in-frail-older-patients-with-diabetes-100494701","NCT05721599","Effectiveness of Integrated Care Combined Nutrition and Lifestyle Counselling in Frail Older Patients With Diabetes","Inclusion Criteria:\n\n* People aged 65 years or older.\n* People with Clinical Frailty Scale: 4-7.\n* People with a history of type II diabetes, use of diabetes medications, or HbA1c greater than or equal to 6.5%.\n* People can understand the research process, meet the requirements of the research, and can sign the informed consent and participate in the following tracking.\n\nExclusion Criteria:\n\n* People that are unable to cooperate with or accept intervention or follow-up.\n* People with a history of type I diabetes.\n* People use insulin injections or pumps.\n* According to the PI's judgment, people with severe or poorly controlled conditions include acute diseases, severe infections, severe abnormal laboratory tests, or serious medical conditions with the following systems: cardiovascular, pulmonary, hepatic, nervous, mental, metabolic, renal, musculoskeletal, gastrointestinal, etc.\n* People with severe visual or hearing impairment that prevent the completion of assessment and testing.\n* People with malignant tumors that have just been diagnosed or are undergoing treatment or are still at risk of recurrence.\n* People have received hormone therapy within three months before the trial or are expected to receive hormone therapy during the trial.\n* People are currently or expected to join any other physical training courses or nutrition plans during the trial.\n* Others are based on the judgment of the PI that participating in this trial may adversely affect the safety of the subjects, hinder the progress of the experiment, or interfere with the evaluation of the outcomes of the trial.","65 Years",{"count":80,"type":23},[83],"The goal of this clinical trial is to evaluate the effectiveness of innovative integrated care in pre-frail or frail patients with diabetes over 65 years old. The main questions it aims to answer are:\n\n* To establish innovative integrated care for frail elderly patients with diabetes combined with nutrition and lifestyle guidance.\n* To evaluate the effectiveness of the intervention compared with general outpatient care.\n\nParticipants will receive 12 weeks of structured care including specialist care, integrated assessment, group health education, one-on-one nutrition and lifestyle guidance, online and face-to-face support group, and case management. Researchers will compare general outpatient care to see its effects on frailty, physical function, and blood sugar control.",[110,194,41],"Diabetes",[110,194,196,197,198,41],"Older adult","Integrated care","Nutrition","2024-08-05",{"date":201,"type":61},"2024-08-07",{"date":203,"type":61},"2023-04-13",{"date":205,"type":23},"2025-12-31",{"name":207,"class":68},"Buddhist Tzu Chi General Hospital",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":17,"sex":216,"minAge":217,"maxAge":218,"enrollmentInfo":219,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":221,"conditions":222,"keywords":225,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":182},"100340363","lifetime-endurance-exercise-to-prevent-coronary-artery-disease-100340363","NCT03711539","Lifetime Endurance Exercise to Prevent Coronary Artery Disease","Lifetime Endurance Exercise to Prevent Coronary Artery Disease. A Comparison With Late-onset Endurance Training and a Sedentary Lifestyle","MASTER@HEART","Inclusion Criteria:\n\n* Lifelong endurance athletes:\n\n  * Initiation of endurance sports before the age of 30 years\n  * Activities at regional, national or international level\n  * Sports: triathlon, cycling, distance running (1500 metres and longer) and rowing\n  * Aged 45-70 years\n  * Involved in competition and high-level training:\n\n    * more than 10 hours per week for cyclists and triathletes\n    * more than 6 hours per week for runners and rowers.\n* Late-onset endurance athletes:\n\n  * Initiation of endurance sports after the age of 30 years and at least 6 months ago\n  * Activities at regional, national or international level\n  * Sports: triathlon, cycling, distance running (1500 metres and longer) and rowing\n  * Aged 45-70 years\n  * Involved in competition and high-level training:\n\n    * more than 10 hours per week for cyclists and triathletes\n    * more than 6 hours per week for runners and rowers.\n* Healthy non-athletes\n\n  * subjects seen in the outpatient clinic for a work-related medical check-up\n  * university alumni\n  * subjects from multisports organisations\n  * history of regular sports practice \\\u003C3 hours \u002Fweek\n  * participation in regular sports with a low dynamic component (e.g. billiards, darts or bowling) \\>3 hours \u002Fweek is allowed\n\nExclusion Criteria:\n\n* history of smoking (\\> 5 pack years)\n* history of diabetes\n* diagnosis of cardiopulmonary disorder prior to inclusion\n* medical treatment for arterial hypertension or hypercholesterolemia","MALE","45 Years","70 Years",{"count":220,"type":23},1800,"The primary objective of the Master@Heart Trial is to investigate whether lifelong endurance exercise reduces the incidence of non-calcified plaques (both mixed and soft plaques) as compared to late-onset endurance exercise and a non-athletic lifestyle.",[223,224,41],"Coronary Artery Disease","Physical Activity",[226,223,227,228,229],"Endurance Exercise","Atrial Fibrillation","Myocardial Fibrosis","Coronary CT","2024-07-02",{"date":232,"type":61},"2024-07-03",{"date":234,"type":61},"2018-10-18",{"date":236,"type":23},"2025-10-01",{"name":238,"class":68},"Universitaire Ziekenhuizen KU Leuven",{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":245,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":18,"minAge":158,"maxAge":189,"enrollmentInfo":247,"targetDuration":4,"studyType":81,"phases":249,"briefSummary":250,"conditions":251,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":261,"locationsCount":69},"100480266","evaluating-the-effectiveness-of-the-gill-ehealth-intervention-to-improve-physical-health-and-lifestyle-behaviours-in-patients-with-severe-mental-illness-100480266","NCT05533749","Evaluating the Effectiveness of the GILL eHealth Intervention to Improve Physical Health and Lifestyle Behaviours in Patients With Severe Mental Illness","Improving Physical Health and Lifestyle Behaviors in Patients With Serious Mental Illness: a Cluster Randomized Controlled Trial on the Effectiveness of the Nurse-led GILL eHealth Intervention","GILL","Inclusion Criteria:\n\n* Meet the criteria of severe mental illness\n* Aged from 18 to 65 years\n* Body mass index (BMI) ≥ 27\n* Access and ability to use internet\n* Able and willing to sign informed consent\n\nExclusion Criteria:\n\n* Contra-indications (to be assessed by the treating physician\u002Fpsychiatrist) for participation due to acute psychiatric crisis or severe somatic diseases\n* Subjects with a cognitive impairment sufficient to interfere with their ability to provide informed consent, complete study questionnaires, or participate in the intervention\n* Pregnant or breastfeeding women at the time of inclusion\n* Subject not able to communicate in the Dutch language",{"count":248,"type":23},258,[83],"The aim of this study is to evaluate the effectiveness of the nurse-led GILL (Gezondheid in Lichaam en Leefstijl) eHealth intervention in patients with serious mental illness (SMI), compared to usual care. Expected is that the GILL eHealth intervention will be more effective than usual care in improving physical health and lifestyle behaviors. To evaluate this, we will perform a cluster randomized controlled trial with an embedded process evaluation of the implementation of the GILL intervention. 258 adult patients with serious mental illness and a body mass index of 27 or higher (overweight\u002Fobesity) will be included. The GILL eHealth intervention consists of two complementary modules for (a) somatic screening and (b) lifestyle promotion, resulting in a personalized somatic treatment and lifestyle plan. Trained mental health nurses and clinical nurse specialists will implement the intervention within the multidisciplinary treatment context, and will guide and support the patients in the promotion of their somatic health, including cardiometabolic risk management. The intervention will be compared to usual care, which includes treatment according to national guidelines. The outcome measures will be metabolic syndrome severity (primary), fitness, physical activity, lifestyle behaviors, quality of life, recovery, psychosocial functioning, health related self-efficacy and health care utilization after 1 year. The process evaluation focuses on the feasibility of the eHealth intervention, its acceptability for patients and health care providers (mainly mental health nurses and clinical nurse specialists), and barriers\u002Ffacilitators to implementation.",[252,32,41,253,254],"Severe Mental Disorder","Somatic Screening","eHealth","2024-06-13",{"date":257,"type":61},"2024-06-14",{"date":259,"type":61},"2024-05-30",{"date":205,"type":23},{"name":262,"class":68},"Amsterdam UMC, location VUmc",{"id":264,"slug":265,"hasResults":11,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":269,"eligibilityCriteria":270,"healthyVolunteers":11,"sex":271,"minAge":158,"maxAge":4,"enrollmentInfo":272,"targetDuration":4,"studyType":81,"phases":274,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":69},"100534616","supporting-lifestyle-changes-after-delivery-100534616","NCT06241144","Supporting Lifestyle Changes After Delivery","Information and Communication Technology -Based Health Behavior Change Support System to Modify Lifestyle After Delivery: Randomized Controlled Intervention Study","STELLA","Inclusion Criteria:\n\n* Pre-pregnancy BMI ≥ 30.0 kg\u002Fm\\^2\n* Smartphone user\n\nExclusion Criteria:\n\n* Eating disorder\n* Severe mental disorder\n* Use of other lifestyle support system or medication\n* Non-Finnish speaker","FEMALE",{"count":273,"type":23},200,[83],"Use of information and communication technology -based health behavior change support system in modifying lifestyle after delivery among women with obesity.",[277,41],"Obesity, Maternal","2024-04-01",{"date":280,"type":61},"2024-04-03",{"date":282,"type":61},"2024-02-09",{"date":284,"type":23},"2032-12-31",{"name":286,"class":68},"Oulu University Hospital",{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":293,"eligibilityCriteria":294,"healthyVolunteers":17,"sex":18,"minAge":158,"maxAge":295,"enrollmentInfo":296,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":298,"conditions":299,"keywords":301,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":304,"lastUpdatePostDateStruct":305,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":69},"100537221","chinese-occupational-population-cohort-of-lifestyle-and-physical-fitness-lifitchina-100537221","NCT06275009","Chinese Occupational Population Cohort of Lifestyle and Physical Fitness (LiFitChina)","Effects of Lifestyle and Physical Fitness on Cardiovascular Health: a Cohort Study in Chinese Occupational Population","LiFitChina","Inclusion Criteria:\n\n* adults between 18-59 years of age\n* occupational staff\n* willing to accept long-term follow-up\n\nExclusion Criteria:\n\n* participants with previous CVD history such as myocardial infarction, stroke and severe aortic stenosis;\n* with cancer;\n* with congenital genetic diseases, or cannot cooperate with the investigation and follow-up due to acquired diseases, such as congenital heart disease, paralysis, deafness, dementia, mental abnormality, developmental retardation, etc.;\n* with exercise contraindications;\n* duration of pregnancy;\n* refuse to sign the informed consent.","59 Years",{"count":297,"type":23},18512,"The incidence and prevalence of metabolic risk factors such as obesity, hypertension, diabetes, and dyslipidemia, as well as cardiovascular diseases (CVD), are continuously rising among the occupational population in China, primarily comprising the middle-aged and young adults. Unhealthy lifestyles and declining physical fitness are independent risk factors affecting cardiovascular health. Additionally, the level of physical fitness is influenced by postnatal lifestyles. Lifestyle factors related to cardiovascular health in the occupational population encompass various aspects, including smoking, physical activity, diet, sleep, psychological stress, etc. These factors may interact or have a synergistic effect, necessitating a comprehensive assessment.\n\nThis project proposes a prospective cohort study design to establish a monitoring cohort for lifestyle and physical fitness among the occupational population. The study will track and follow individuals with or without any CVD metabolic risk factors, collecting information on general status, lifestyle, physical fitness, and health examination data. Exposure factors such as lifestyle and physical fitness will be measured annually, and the occurrence of CVD-related health outcomes will be observed. The aim is to develop a comprehensive evaluation index for cardiovascular health lifestyle, analyze the direct and indirect impacts of lifestyle and physical fitness on the occurrence and development of CVD, and explore potential mediating and moderating effects of physical fitness in the association between lifestyle and cardiovascular health.",[41,300,33],"Physical Fitness",[41,302,33,303],"physical fitness","cohort","2024-02-26",{"date":306,"type":61},"2024-02-28",{"date":308,"type":61},"2023-12-11",{"date":310,"type":23},"2026-12-11",{"name":312,"class":313},"China National Center for Cardiovascular Diseases","OTHER_GOV",{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":320,"eligibilityCriteria":321,"healthyVolunteers":11,"sex":18,"minAge":158,"maxAge":4,"enrollmentInfo":322,"targetDuration":4,"studyType":81,"phases":324,"briefSummary":325,"conditions":326,"keywords":330,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":345,"locationsCount":347},"100420432","aerobic-fitness-or-muscle-mass-training-to-improve-colorectal-cancer-outcome-100420432","NCT04754672","Aerobic Fitness or Muscle Mass Training to Improve Colorectal Cancer Outcome","Aerobic Fitness or Muscle Mass Training to Improve Colorectal Cancer Outcome (AMICO). The Effects of Exercise on Chemotherapy Dose Modification and Progression Free Survival in Patients With Metastatic Colorectal Cancer","AMICO","Inclusion Criteria:\n\n* mCRC with indication for palliative chemotherapy\n* scheduled for treatment with first-line doublet or triplet chemotherapy, according to the national guideline\n* able and willing to give written informed consent.\n\nExclusion Criteria:\n\n* life expectancy \\\u003C6 months\n* unable to perform basic activities of daily living such as walking or biking\n* presence of cognitive disorders or severe emotional instability (e.g., Schizophrenia, Alzheimer, alcohol addiction);\n* presence of other disabling co-morbidities that might hamper physical exercise (e.g. heart failure (NYHA classes 3 and 4), chronic obstructive pulmonary disease (COPD, gold 3 and 4), orthopaedic conditions and neurological disorders (e.g., hernia, paresis, amputation, active rheumatoid arthritis);\n* insufficient mastery of the Dutch language;\n* presence of serious cardiovascular or cardiopulmonary conditions (e.g. unstable angina, arrhythmia or valve disease) such that exercise safety is at risk, as judged by the treating physician.\n* Already participating in structured vigorous aerobic and\u002For resistance exercise ≥ 2 times per week comparable to our intervention",{"count":323,"type":23},228,[83],"Evidence from randomized controlled trials shows that exercise during cancer treatment benefits physical fitness, fatigue and quality of life. Since the effect of exercise on clinical outcome is currently unknown, exercise is not included as integral part of standard cancer care. Moreover, evidence regarding the optimal exercise prescription in terms of type and dose is lacking.\n\nTo maintain quality of life in patients receiving palliative treatment with chemotherapy, toxicity-induced modifications in the prescribed chemotherapy dose are common. Such modifications - occurring in 40% of patients with metastatic colorectal cancer - may reduce benefit of treatment. The investigators hypothesize that exercise prevents chemotherapy dose modifications by reducing toxicity and enhancing psychological strength. Additionally, based on studies in rodents and preliminary data in patients with cancer, the researchers hypothesize that exercise has beneficial effects on the functionality of the natural killer cells, which play an important role in the innate immune defense against cancer. Both, fewer dose modifications and improved immune function may improve progression-free survival.\n\nThis study is a three-armed trial comparing resistance exercise, aerobic interval exercise and usual care in patients with metastatic colorectal cancer to select the optimal exercise prescription for preventing chemotherapy dose modifications. The trial will use a Bayesian adaptive multi-arm multi-stage design with several interim analyses after which an ineffective study arm can be dropped early. This novel design makes the trial more efficient and reduces patients' exposure to suboptimal study arms.\n\nEvidence regarding the exercise effects on i) clinical outcome, ii) the optimal exercise prescription, and iii) the underlying mechanisms, elucidates the potential of exercise to boost benefit from chemotherapy treatment. This evidence provides leads to improve progression-free survival and quality of life of patients suffering from one of the leading causes of cancer death worldwide.",[327,328,329,41],"Colorectal Cancer","Chemotherapeutic Toxicity","Survivorship",[331,332,333,334,335,336,337],"Exercise","Muscle strength","Cardiorespiratory fitness","Colorectal cancer","Chemotherapy dose modification","Progression free survival","Bayesian adaptive trial","2023-11-16",{"date":340,"type":61},"2023-11-18",{"date":342,"type":61},"2021-03-02",{"date":344,"type":23},"2026-12",{"name":346,"class":68},"Radboud University Medical Center",13,{"id":349,"slug":350,"hasResults":11,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":354,"eligibilityCriteria":355,"healthyVolunteers":11,"sex":18,"minAge":158,"maxAge":356,"enrollmentInfo":357,"targetDuration":359,"studyType":24,"phases":4,"briefSummary":360,"conditions":361,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":69},"100414888","the-prospective-observational-compraya-cohort-study-100414888","NCT04682470","The Prospective Observational COMPRAYA Cohort Study","COMPRehensive Assessment of Prevalence, Risk Factors and Mechanisms of Impaired Medical and Psychosocial Health Outcomes Among Adolescents and Young Adults With Cancer: the Prospective Observational COMPRAYA Cohort Study","COMPRAYA","Inclusion Criteria:\n\n* Pathological confirmed cancer diagnosis;\n* Age 18 - 39 years at time of first cancer diagnosis;\n* Able to understand the informed consent form;\n* Provide written informed consent.\n\nExclusion Criteria:\n\n* Mentally incompetent patients based on the opinion of treating physician .\n* Inability to understand the Dutch language\n* Life expectancy less than 6 months based on the opinion of treating physician .","39 Years",{"count":358,"type":23},4000,"10 Years","Rationale: Childhood cancer survivorship attracts attention globally, because successes in treatment have led to increasing number of survivors who reach adulthood, in which survivorship issues affecting health-related quality of life (HRQoL) become prominent. Most paediatric patients are treated intensively with irradiation and\u002For chemotherapy, which put them at risk for early and\u002For late adverse medical and psychosocial events. In contrast, much less is known about adolescent and young adult (AYA) cancer patients, diagnosed between 18-39 years, who, with an 80% chance to survive, also have a long life ahead. AYA cancer patients, much more than children, suffer from delay in diagnosis, lack of centralization of care, ageadjusted expertise, and AYA follow-up care. AYAs typically present with a rare tumour: either with a paediatric malignancy (e.g. acute lymphoblastic leukaemia, paediatric brain tumours), a more typical tumour of AYA age (e.g. Hodgkin's disease, germ cell cancer, melanoma, thyroid cancer) or with an adult tumour at unusual young age (e.g. gastrointestinal, lung, breast carcinomas). Next to these differences in epidemiology, the tumour biology, developmental challenges (e.g. forming relationships, becoming financially independent, having children) and treatment regimens differ between AYAs and children, and therefore findings derived from childhood cancer survivors cannot be extrapolated to AYAs. Furthermore, novel treatments with targeted agents or immunotherapy are more likely to be administrated to AYAs compared to children. Finally, a rare group of incurable AYA cancer patients will survive for many years, for whom health outcome and supportive care intervention data are lacking.\n\nGlobally, so far, the identification of AYA cancer patient subgroups that might be more susceptible to poor health outcomes has not been systematically addressed. The role of sociodemographic and treatment-associated risks, external exposures (e.g. lifestyle) and host factors (e.g. genetic, biological, physiological); or combinations of influences for impaired (agespecific) health outcomes, remains largely unknown. Understanding who is at risk and why will support the development of evidence-based AYA prevention, treatment and supportive care programs and guidelines, in co-creation with AYA cancer patients.\n\nObjective: To examine the prevalence, risk factors and mechanisms of impaired health outcomes (short- and long-term medical and psychosocial effects and late effects) over time among a population-based sample of AYA cancer patients.\n\nStudy design: Prospective, observational cohort study Study population: All AYAs diagnosed (18-39 years at primary diagnosis) with cancer (any type) within the first 3 months after diagnosis (eligibility window of 1 month to ensure all eligible AYA cancer patients can be included) in one of the participating centres (or treated in one of these centres) in The Netherlands.\n\nMain study parameters\u002Fendpoints: The main outcomes are medical (e.g. second tumour; survival; fertility) and psychosocial (e.g. distress) health outcomes. Other study parameters (covariates\u002Fmoderators\u002Fmediators) are characteristics of the individual (e.g. age, sex, cultural background, partner status, educational level, occupation, tumour type, disease stage, body composition, comorbid conditions, coping style), characteristics of the environment (e.g. cancer treatment, lifestyle), and genetic and biological factors (e.g. family history of cancer, stress and inflammation markers (e.g. cortisol, IL-6), microbiome).\n\nNature and extent of the burden and risks associated with participation, benefit and group relatedness: On an individual level, patients who participate are asked to complete questionnaires on an annual basis for at least 10 years. All sample collections will take place at three time points: 0-3 months after diagnosis (baseline), 2 and 5 years; except blood for DNA analyses which will only take place at baseline. The collection of blood, hair and faeces at three occasions is minimally invasive and the risks of blood draws, hair and fecal sampling are negligible. All safety measures and procedures will be performed according to local guidelines. Patients will not experience direct benefit from participation in the COMPRAYA study.\n\nBy participating, patients will contribute to a better insight in the prevalence of impaired medical and psychosocial (age-specific) health outcomes in AYA and evidence on factors associated with these health outcomes. This will lead to better and more personalized cancer care and supportive care tools for future AYA cancer patients.",[362,329,363,364,41,365,366],"Second Cancer","Fertility Issues","Distress, Emotional","Genetic Disease","Cancer","2022-02-11",{"date":369,"type":61},"2022-03-02",{"date":371,"type":61},"2021-06-18",{"date":373,"type":23},"2035-06",{"name":375,"class":68},"The Netherlands Cancer Institute"]